YUKI ASAKAWA

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
yukitannhiroshima-u.ac.jp
Self-introduction
Osteoarthritis is a disease whose main symptoms are destruction of mandibular condyle cartilage, deformity of bone, and perforation of disc. We are conducting research aimed at elucidating the mechanism of mandibular condylar cartilage destruction in osteoarthritis of the temporomandibular joint and developing new treatment methods. In clinical research, we are investigating methods for objectively evaluating the effects of oral muscle function training.

Basic Information

Major Professional Backgrounds

  • 2008/04/01, 2009/03/31, Hiroshima University Hospital, Clinical Fellow
  • 2009/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Japan, 2004/04, 2008/03
  • Osaka University, Japan, 1998/04, 2004/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Orthodontics / Pediatric dentistry

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 1Term, Orthodontics I
  2. 2025, Undergraduate Education, 2Term, Orthodontics II
  3. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  4. 2025, Undergraduate Education, 3Term, Basic Practice of Orthodontics I
  5. 2025, Undergraduate Education, 4Term, Basic Practice of Orthodontics II
  6. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  7. 2025, Undergraduate Education, 2Term, Advanced Course in Growth and Development of Occlusion
  8. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  9. 2025, Undergraduate Education, Year, Clinical Practice (Preventive Dentistry)
  10. 2025, Undergraduate Education, Year, Clinical Practice (Orthodontics)
  11. 2025, Undergraduate Education, 1Term, Orthodontics
  12. 2025, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  13. 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health
  14. 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  15. 2025, Undergraduate Education, 1Term, Orthodontics
  16. 2025, Undergraduate Education, 3Term, Practice of Orthodontics I
  17. 2025, Undergraduate Education, 4Term, Practice of Orthodontics II
  18. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
  19. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
  20. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
  21. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
  22. 2025, Graduate Education (Doctoral Program) , First Semester, Training Course for Orthodontic Specialist
  23. 2025, Graduate Education (Doctoral Program) , Second Semester, Training Course for Orthodontic Specialist

Research Activities

Academic Papers

  1. Longitudinal effects of estrogen on mandibular growth and changes in cartilage during the growth period in rats, DEVELOPMENTAL BIOLOGY, 492, 126-132, 202212
    Link to Paper Search Results by DOI
  2. Characteristics of the Maxillofacial Morphology in Patients with Idiopathic Mandibular Condylar Resorption, JOURNAL OF CLINICAL MEDICINE, 11(4), 202202
    Link to Paper Search Results by DOI
  3. Differential Effects of Amelogenin on Mineralization of Cementoblasts and Periodontal Ligament Cells, JOURNAL OF PERIODONTOLOGY, 83(5), 672-679, 201205
    Link to Paper Search Results by DOI
  4. Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow, CELLS TISSUES ORGANS, 196(5), 411-419, 2012
    Link to Paper Search Results by DOI
  5. A case of mandibular protrusion with temporomandibular joint disorder, 17, 49-59, 20050401
  6. Occlusion, craniofacial morphology and mandibular kinetic function in a juvenile patient with left facial palsy, 18(1), 29-36, 20060701
  7. Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase, Archives of Oral Biology, 53(4), 330-336, 20080401
  8. Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells., Arch Oral Biol, 54(8), 757-763, 20090801
  9. The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading., Ann Biomed Eng, 37(7), 1358-1367, 20090701
  10. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system., Eur J Oral Sci, 118(2), 151-158, 20100401
  11. Modulation of hyaluronan fragmentation by interleukin-1 beta in synovial membrane cells., Ann Biomed Eng, 38(4), 1618-1625, 20100401
  12. Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli., J Biomed Mater Res A, 93(1), 373-380, 20100401
  13. Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes., J Biomed Mater Res A, 92(2), 801-805, 20100201
  14. Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells., J Biomed Mater Res A, 92(1), 87-93, 20100101
  15. A treat case of posterior open bite produced by a long-term use of occlusal splint for temporomandibular joint disorders, 42(2), 160－165, 20101201
  16. Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow, Cell Tissue Res, 342(2), 205-12, 20101101
  17. Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle., Arch Oral Biol, 56(11), 1412-8, 20111101
  18. Amelogenin enhances the proliferation of cementoblast lineage cells., J Periodontol, 82(11), 1632-8, 20111101
  19. Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage., Cell Tissue Res, 344(2), 333-40, 20110501
  20. Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone., Int J Dent, 20120301
  21. Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone, International Journal of Dentistry, 352510, 20120401
  22. Effects of hyaluronan oligosaccharides on apoptosis of human gingival fibroblasts, Open Journal of Stomatology, 3(1), 19-24, 20130301
  23. Expression of superficial zone protein in mandibular condyle cartilage, OSTEOARTHRITIS AND CARTILAGE, 14(8), 807-813, 200608
    Link to Paper Search Results by DOI
  24. Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase, ARCHIVES OF ORAL BIOLOGY, 53(4), 330-336, 200804
    Link to Paper Search Results by DOI
  25. The effect of mechanical loading on the metabolism of growth plate chondrocytes, ANNALS OF BIOMEDICAL ENGINEERING, 36(5), 793-800, 200805
    Link to Paper Search Results by DOI
  26. Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation, ARCHIVES OF ORAL BIOLOGY, 53(5), 478-487, 200805
    Link to Paper Search Results by DOI
  27. An Adolescent Patient with Multiple Impacted Teeth, ANGLE ORTHODONTIST, 78(6), 1110-1118, 200811
    Link to Paper Search Results by DOI
  28. The Mandibular Cartilage Metabolism is Altered by Damaged Subchondral Bone from Traumatic Impact Loading, ANNALS OF BIOMEDICAL ENGINEERING, 37(7), 1358-1367, 200907
    Link to Paper Search Results by DOI
  29. Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells, ARCHIVES OF ORAL BIOLOGY, 54(8), 757-763, 200908
    Link to Paper Search Results by DOI
  30. Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(1), 87-93, 201001
    Link to Paper Search Results by DOI
  31. Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(2), 801-805, 201002
    Link to Paper Search Results by DOI
  32. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system, EUROPEAN JOURNAL OF ORAL SCIENCES, 118(2), 151-158, 201004
    Link to Paper Search Results by DOI
  33. Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow, CELL AND TISSUE RESEARCH, 342(2), 205-212, 201011
    Link to Paper Search Results by DOI
  34. Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage, CELL AND TISSUE RESEARCH, 344(2), 333-340, 201105
    Link to Paper Search Results by DOI
  35. Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle, ARCHIVES OF ORAL BIOLOGY, 56(11), 1412-1418, 201111
    Link to Paper Search Results by DOI
  36. Amelogenin Enhances the Proliferation of Cementoblast Lineage Cells, JOURNAL OF PERIODONTOLOGY, 82(11), 1632-1638, 201111
    Link to Paper Search Results by DOI
  37. Synthesis of hyaluronan and superficial zone protein in synovial membrane cells modulated by fluid flow, EUROPEAN JOURNAL OF ORAL SCIENCES, 121(6), 566-572, 201312
    Link to Paper Search Results by DOI
  38. Effects of Low-Intensity Pulsed Ultrasound on the Expression of Cyclooxygenase-2 in Mandibular Condylar Chondrocytes, JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, 28(3), 261-268, 2014
    Link to Paper Search Results by DOI
  39. ★, Effects of Enzymatic Degradation after Loading in Temporomandibular Joint, JOURNAL OF DENTAL RESEARCH, 94(2), 337-343, 201502
    Link to Paper Search Results by DOI
  40. Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells, CLEFT PALATE-CRANIOFACIAL JOURNAL, 52(4), 386-394, 201507
    Link to Paper Search Results by DOI
  41. Craniofacial Growth and Orthodontic Treatment of Cleft Lip and Palate Patient with Furlow's Method for Soft Palate Repair in Two-stage Palatoplasty, 45(2), 105-111, 2013
  42. Current status of temporomandibular joint disorders and the therapeutic system derived from a series of biomechanical, histological, and biochemical studies., APOS Trends in Orthodontics, 58-75
  43. The C-terminus of the amelogenin peptide influences the proliferation of human bone marrow mesenchymal stem cells, JOURNAL OF PERIODONTOLOGY, 89(4), 496-505, 201804
    Link to Paper Search Results by DOI
  44. Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, MEDIATORS OF INFLAMMATION, 2018
    Link to Paper Search Results by DOI
  45. Hyaluronan enhances proteoglycan4 expression in synovial cells, Archives of Medical Research, 5(2), 201701
  46. Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes, INFLAMMATION, 41(5), 1621-1630, 201810
    Link to Paper Search Results by DOI
  47. Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress, CELL BIOLOGY INTERNATIONAL, 44(4), 966-974, 202004
    Link to Paper Search Results by DOI
  48. Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Mediators Inflamm, 2018, 20180408
  49. FAK inhibition protects condylar cartilage under excessive mechanical stress, ORAL DISEASES, 26(8), 1736-1746, 202011
    Link to Paper Search Results by DOI
  50. ANGPTL2 Induces Synovial Inflammation via LILRB2, INFLAMMATION, 44(3), 1108-1118, 202106
    Link to Paper Search Results by DOI
  51. ANGPTL2 Promotes Inflammation via Integrin alpha 5 beta 1 in Chondrocytes, CARTILAGE, 13(2_SUPPL), 885S-897S, 202112
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of Semaphorin3A in endochondral ossification of mandibular condyle, Tsuboi E., Asakawa Y., Hirose N., Yanoshita M., Takano M., Nishiyama S., Kubo N., Onishi A., Yamauchi Y., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society, 2020/10/04, Without Invitation, English
  2. A case of surgical orthodontic treatment for a patient with osteogenesis imperfecta, Takano M., Asakawa Y., Hirose N., Tsuboi E., Nakatani A., Kunimatsu R., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society, 2020/10/04, Without Invitation, English
  3. Familial cases with Hyper-IgE syndrome, Oral/maxillofacial features and Orthodontic treatment plan, Yanoshita M., Hirose N., Takano M., Onishi A., Yamauchi Y., Nishiyama S., Kagawa H., Tsuboi E., Kubo N., Asakawa Y., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society (, 2020/10/04, Without Invitation, English
  4. ANGPTL2 promotes inflammation via integrin a5B1 in chondrocytes, Takano M., Hirose N., Yanoshita M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint, 2019/07/27, Without Invitation, Japanese
  5. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model, Yanoshita M., Hirose N., Takano M., Nishiyama S., Onishi A., Yamauchi Y., Tsuboi E., Asakawa Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint, 2019/07/17, Without Invitation, Japanese
  6. Anti - inflammatory effects of FAK inhibitor on condylar cartilage under excessive mechanical stress, Yanoshita M., Hirose N., Takano M., Sumi C., Nishiyama S., Tsuboi E., Asakawa Y., Onishi A., Yamauchi Y., Tanimoto K, : The 97th General Session of International Association for Dental Research, 2019/06/19, Without Invitation, English
  7. Semaphorin3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Hirose N., Sumi C., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 97th General Session of International Association for Dental Research, 2019/06/19, Without Invitation, English, Vancouver
  8. Effects of Low molecular weight hyaluronan on the expression of PRG4 through CD44 in synovial membrane cells, Mitsuyoshi T, Asakawa Y, Hirose N, Okamoto Y, Yanoshita M, Tanne K, Tanimoto K, 8th international orthodontic congress, 2015/09, Without Invitation, Japanese, published
  9. Effects of human full length amelogenin on the proliferation of human osteoblasts, Kunimatsu R, Yoshimi Y,Awada T,Asakawa Y,Hirose N,Mitsuyoshi T, Sumi K, Gunji h, Tsuka Y, Tanne K, Tanimoto K, The 74th Annual Meeting of the Japanese Orthodontic Society, 2015/11/18, Without Invitation, English, Fukuoka, preprint
  10. ANGPTL2 promotes inflammation in chondrocytes, 2019/07/27, Without Invitation, Japanese
  11. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model, 2019/07/27, Without Invitation, Japanese
  12. Clinical survey on the association between root resorption incident to orthodontic treatment and host factors, 2018/07/07, Without Invitation, Japanese

Awards

  1. The Encouragement Award of the Japanese Orthodontic Society, Longitudinal effects of estrogen on mandibular growth and changes in cartilage during the growth period in rats

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2022, 2024
  2. KAKENHI, 2013, 2014
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  3. KAKENHI, Elucidation of condylar cartilage resorption mechanism in TMJ-osteoarthritis and search of a new regulatory factor., 2011, 2013
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  4. KAKENHI, Optimization of bone regeneration by use of mesenchymal stem cells and its application for closure of jaw cleft, 2011, 2013
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  5. KAKENHI, Investigation of the mechanism of cartilage destruction induced by COX-2 in temporomandibular joint osteoarthrosis and establishment of anti-inflammatory drug treatment, 2011, 2012
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  6. KAKENHI, Effects of low-intensity ultrasound stimulation osteoarthritis, 2010, 2012
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  7. KAKENHI, Applications of amelogenin to the induction of bone regeneration by using mesenchymal stem cells, 2009, 2010
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  8. 2017/10/02
  9. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020

Social Activities

Organizing Academic Conferences, etc.

  1. 2021/02, 2021/03