YUKI ASAKAWA

Last Updated :2023/01/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
yukitannhiroshima-u.ac.jp
Self-introduction
Osteoarthritis is a disease whose main symptoms are destruction of mandibular condyle cartilage, deformity of bone, and perforation of disc. We are conducting research aimed at elucidating the mechanism of mandibular condylar cartilage destruction in osteoarthritis of the temporomandibular joint and developing new treatment methods. In clinical research, we are investigating methods for objectively evaluating the effects of oral muscle function training.

Basic Information

Major Professional Backgrounds

  • 2008/04/01, 2009/03/31, Hiroshima University Hospital, Clinical Fellow
  • 2009/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Japan, 2004/04, 2008/03
  • Hiroshima University, Japan, 1998/04, 2004/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Orthodontics / Pediatric dentistry

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 1Term, Orthodontics I
  2. 2022, Undergraduate Education, 2Term, Orthodontics II
  3. 2022, Undergraduate Education, First Semester, Dental Research Practices
  4. 2022, Undergraduate Education, 3Term, Basic Practice of Orthodontics I
  5. 2022, Undergraduate Education, 4Term, Basic Practice of Orthodontics II
  6. 2022, Undergraduate Education, Second Semester, Dental Research Practices
  7. 2022, Undergraduate Education, First Semester, Dental Research Practices
  8. 2022, Undergraduate Education, Academic Year, Clinical Practice (Orthodontics)
  9. 2022, Undergraduate Education, 1Term, Orthodontics
  10. 2022, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  11. 2022, Undergraduate Education, Intensive, Clinical practice on oral health
  12. 2022, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  13. 2022, Undergraduate Education, 1Term, Orthodontics
  14. 2022, Undergraduate Education, 3Term, Practice of Orthodontics I
  15. 2022, Undergraduate Education, 4Term, Practice of Orthodontics II
  16. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
  17. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
  18. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
  19. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
  20. 2022, Graduate Education (Doctoral Program) , First Semester, Training Course for Orthodontic Specialist
  21. 2022, Graduate Education (Doctoral Program) , Second Semester, Training Course for Orthodontic Specialist

Research Activities

Academic Papers

  1. Characteristics of the Maxillofacial Morphology in Patients with Idiopathic Mandibular Condylar Resorption, JOURNAL OF CLINICAL MEDICINE, 11(4), 202202
  2. Differential Effects of Amelogenin on Mineralization of Cementoblasts and Periodontal Ligament Cells, JOURNAL OF PERIODONTOLOGY, 83(5), 672-679, 201205
  3. Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow, CELLS TISSUES ORGANS, 196(5), 411-419, 2012
  4. A case of mandibular protrusion with temporomandibular joint disorder, 17, 49-59, 20050401
  5. Occlusion, craniofacial morphology and mandibular kinetic function in a juvenile patient with left facial palsy, 18(1), 29-36, 20060701
  6. Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase, Archives of Oral Biology, 53(4), 330-336, 20080401
  7. Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells., Arch Oral Biol, 54(8), 757-763, 20090801
  8. The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading., Ann Biomed Eng, 37(7), 1358-1367, 20090701
  9. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system., Eur J Oral Sci, 118(2), 151-158, 20100401
  10. Modulation of hyaluronan fragmentation by interleukin-1 beta in synovial membrane cells., Ann Biomed Eng, 38(4), 1618-1625, 20100401
  11. Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli., J Biomed Mater Res A, 93(1), 373-380, 20100401
  12. Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes., J Biomed Mater Res A, 92(2), 801-805, 20100201
  13. Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells., J Biomed Mater Res A, 92(1), 87-93, 20100101
  14. A treat case of posterior open bite produced by a long-term use of occlusal splint for temporomandibular joint disorders, 42(2), 160-165, 20101201
  15. Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow, Cell Tissue Res, 342(2), 205-12, 20101101
  16. Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle., Arch Oral Biol, 56(11), 1412-8, 20111101
  17. Amelogenin enhances the proliferation of cementoblast lineage cells., J Periodontol, 82(11), 1632-8, 20111101
  18. Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage., Cell Tissue Res, 344(2), 333-40, 20110501
  19. Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone., Int J Dent, 20120301
  20. Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone, International Journal of Dentistry, 352510, 20120401
  21. Effects of hyaluronan oligosaccharides on apoptosis of human gingival fibroblasts, Open Journal of Stomatology, 3(1), 19-24, 20130301
  22. Expression of superficial zone protein in mandibular condyle cartilage, OSTEOARTHRITIS AND CARTILAGE, 14(8), 807-813, 200608
  23. Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase, ARCHIVES OF ORAL BIOLOGY, 53(4), 330-336, 200804
  24. The effect of mechanical loading on the metabolism of growth plate chondrocytes, ANNALS OF BIOMEDICAL ENGINEERING, 36(5), 793-800, 200805
  25. Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation, ARCHIVES OF ORAL BIOLOGY, 53(5), 478-487, 200805
  26. An Adolescent Patient with Multiple Impacted Teeth, ANGLE ORTHODONTIST, 78(6), 1110-1118, 200811
  27. The Mandibular Cartilage Metabolism is Altered by Damaged Subchondral Bone from Traumatic Impact Loading, ANNALS OF BIOMEDICAL ENGINEERING, 37(7), 1358-1367, 200907
  28. Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells, ARCHIVES OF ORAL BIOLOGY, 54(8), 757-763, 200908
  29. Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(1), 87-93, 201001
  30. Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(2), 801-805, 201002
  31. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system, EUROPEAN JOURNAL OF ORAL SCIENCES, 118(2), 151-158, 201004
  32. Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow, CELL AND TISSUE RESEARCH, 342(2), 205-212, 201011
  33. Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage, CELL AND TISSUE RESEARCH, 344(2), 333-340, 201105
  34. Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle, ARCHIVES OF ORAL BIOLOGY, 56(11), 1412-1418, 201111
  35. Amelogenin Enhances the Proliferation of Cementoblast Lineage Cells, JOURNAL OF PERIODONTOLOGY, 82(11), 1632-1638, 201111
  36. Synthesis of hyaluronan and superficial zone protein in synovial membrane cells modulated by fluid flow, EUROPEAN JOURNAL OF ORAL SCIENCES, 121(6), 566-572, 201312
  37. Effects of Low-Intensity Pulsed Ultrasound on the Expression of Cyclooxygenase-2 in Mandibular Condylar Chondrocytes, JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, 28(3), 261-268, 2014
  38. ★, Effects of Enzymatic Degradation after Loading in Temporomandibular Joint, JOURNAL OF DENTAL RESEARCH, 94(2), 337-343, 201502
  39. Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells, CLEFT PALATE-CRANIOFACIAL JOURNAL, 52(4), 386-394, 201507
  40. Craniofacial Growth and Orthodontic Treatment of Cleft Lip and Palate Patient with Furlow's Method for Soft Palate Repair in Two-stage Palatoplasty, 45(2), 105-111, 2013
  41. Current status of temporomandibular joint disorders and the therapeutic system derived from a series of biomechanical, histological, and biochemical studies., APOS Trends in Orthodontics, 58-75
  42. The C-terminus of the amelogenin peptide influences the proliferation of human bone marrow mesenchymal stem cells, JOURNAL OF PERIODONTOLOGY, 89(4), 496-505, 201804
  43. Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, MEDIATORS OF INFLAMMATION, 2018
  44. Hyaluronan enhances proteoglycan4 expression in synovial cells, Archives of Medical Research, 5(2), 201701
  45. Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes, INFLAMMATION, 41(5), 1621-1630, 201810
  46. Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress, CELL BIOLOGY INTERNATIONAL, 44(4), 966-974, 202004
  47. Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Mediators Inflamm, 2018, 20180408
  48. FAK inhibition protects condylar cartilage under excessive mechanical stress, ORAL DISEASES, 26(8), 1736-1746, 202011
  49. ANGPTL2 Induces Synovial Inflammation via LILRB2, INFLAMMATION, 44(3), 1108-1118, 202106
  50. ANGPTL2 Promotes Inflammation via Integrin alpha 5 beta 1 in Chondrocytes, CARTILAGE, 13(2_SUPPL), 885S-897S, 202112

Invited Lecture, Oral Presentation, Poster Presentation

  1. Role of Semaphorin3A in endochondral ossification of mandibular condyle, Tsuboi E., Asakawa Y., Hirose N., Yanoshita M., Takano M., Nishiyama S., Kubo N., Onishi A., Yamauchi Y., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society, 2020/10/04, Without Invitation, English
  2. A case of surgical orthodontic treatment for a patient with osteogenesis imperfecta, Takano M., Asakawa Y., Hirose N., Tsuboi E., Nakatani A., Kunimatsu R., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society, 2020/10/04, Without Invitation, English
  3. Familial cases with Hyper-IgE syndrome, Oral/maxillofacial features and Orthodontic treatment plan, Yanoshita M., Hirose N., Takano M., Onishi A., Yamauchi Y., Nishiyama S., Kagawa H., Tsuboi E., Kubo N., Asakawa Y., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society (, 2020/10/04, Without Invitation, English
  4. ANGPTL2 promotes inflammation via integrin a5B1 in chondrocytes, Takano M., Hirose N., Yanoshita M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint, 2019/07/27, Without Invitation, Japanese
  5. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model, Yanoshita M., Hirose N., Takano M., Nishiyama S., Onishi A., Yamauchi Y., Tsuboi E., Asakawa Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress for Temporomandibular Joint, 2019/07/17, Without Invitation, Japanese
  6. Anti - inflammatory effects of FAK inhibitor on condylar cartilage under excessive mechanical stress, Yanoshita M., Hirose N., Takano M., Sumi C., Nishiyama S., Tsuboi E., Asakawa Y., Onishi A., Yamauchi Y., Tanimoto K, : The 97th General Session of International Association for Dental Research, 2019/06/19, Without Invitation, English
  7. Semaphorin3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Hirose N., Sumi C., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 97th General Session of International Association for Dental Research, 2019/06/19, Without Invitation, English, Vancouver
  8. Effects of Low molecular weight hyaluronan on the expression of PRG4 through CD44 in synovial membrane cells, Mitsuyoshi T, Asakawa Y, Hirose N, Okamoto Y, Yanoshita M, Tanne K, Tanimoto K, 8th international orthodontic congress, 2015/09, Without Invitation, Japanese, published
  9. Effects of human full length amelogenin on the proliferation of human osteoblasts, Kunimatsu R, Yoshimi Y,Awada T,Asakawa Y,Hirose N,Mitsuyoshi T, Sumi K, Gunji h, Tsuka Y, Tanne K, Tanimoto K, The 74th Annual Meeting of the Japanese Orthodontic Society, 2015/11/18, Without Invitation, English, Fukuoka, preprint
  10. ANGPTL2 promotes inflammation in chondrocytes, 2019/07/27, Without Invitation, Japanese
  11. Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model, 2019/07/27, Without Invitation, Japanese
  12. Clinical survey on the association between root resorption incident to orthodontic treatment and host factors, 2018/07/07, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2014
  2. KAKENHI, Elucidation of condylar cartilage resorption mechanism in TMJ-osteoarthritis and search of a new regulatory factor., 2011, 2013
  3. KAKENHI, Optimization of bone regeneration by use of mesenchymal stem cells and its application for closure of jaw cleft, 2011, 2013
  4. KAKENHI, Investigation of the mechanism of cartilage destruction induced by COX-2 in temporomandibular joint osteoarthrosis and establishment of anti-inflammatory drug treatment, 2011, 2012
  5. KAKENHI, Effects of low-intensity ultrasound stimulation osteoarthritis, 2010, 2012
  6. KAKENHI, Applications of amelogenin to the induction of bone regeneration by using mesenchymal stem cells, 2009, 2010
  7. 2017/10/02
  8. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020

Social Activities

Organizing Academic Conferences, etc.

  1. 2021/02, 2021/03