YUKI ASAKAWA
Last Updated :2025/05/09
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
- E-mail
- yukitann
hiroshima-u.ac.jp
- Self-introduction
- Osteoarthritis is a disease whose main symptoms are destruction of mandibular condyle cartilage, deformity of bone, and perforation of disc. We are conducting research aimed at elucidating the mechanism of mandibular condylar cartilage destruction in osteoarthritis of the temporomandibular joint and developing new treatment methods.
In clinical research, we are investigating methods for objectively evaluating the effects of oral muscle function training.
Basic Information
Major Professional Backgrounds
- 2008/04/01, 2009/03/31, Hiroshima University Hospital, Clinical Fellow
- 2009/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Assistant Professor
- 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
Educational Backgrounds
- Hiroshima University, Japan, 2004/04, 2008/03
- Osaka University, Japan, 1998/04, 2004/03
Academic Degrees
- Doctor of Philosophy in Dental Science, Hiroshima University
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
Research Fields
- Medicine,dentistry, and pharmacy;Dentistry;Orthodontics / Pediatric dentistry
Educational Activity
Course in Charge
- 2025, Undergraduate Education, 1Term, Orthodontics I
- 2025, Undergraduate Education, 2Term, Orthodontics II
- 2025, Undergraduate Education, First Semester, Dental Research Practices I
- 2025, Undergraduate Education, 3Term, Basic Practice of Orthodontics I
- 2025, Undergraduate Education, 4Term, Basic Practice of Orthodontics II
- 2025, Undergraduate Education, Second Semester, Dental Research Practices II
- 2025, Undergraduate Education, 2Term, Advanced Course in Growth and Development of Occlusion
- 2025, Undergraduate Education, First Semester, Dental Research Practices III
- 2025, Undergraduate Education, Year, Clinical Practice (Preventive Dentistry)
- 2025, Undergraduate Education, Year, Clinical Practice (Orthodontics)
- 2025, Undergraduate Education, 1Term, Orthodontics
- 2025, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
- 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health
- 2025, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
- 2025, Undergraduate Education, 1Term, Orthodontics
- 2025, Undergraduate Education, 3Term, Practice of Orthodontics I
- 2025, Undergraduate Education, 4Term, Practice of Orthodontics II
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Orthodontics and Craniofacial Developmental Biology
- 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
- 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Orthodontics and Craniofacial Developmental Biology
- 2025, Graduate Education (Doctoral Program) , First Semester, Training Course for Orthodontic Specialist
- 2025, Graduate Education (Doctoral Program) , Second Semester, Training Course for Orthodontic Specialist
Research Activities
Academic Papers
- Longitudinal effects of estrogen on mandibular growth and changes in cartilage during the growth period in rats, DEVELOPMENTAL BIOLOGY, 492, 126-132, 202212
- Characteristics of the Maxillofacial Morphology in Patients with Idiopathic Mandibular Condylar Resorption, JOURNAL OF CLINICAL MEDICINE, 11(4), 202202
- Differential Effects of Amelogenin on Mineralization of Cementoblasts and Periodontal Ligament Cells, JOURNAL OF PERIODONTOLOGY, 83(5), 672-679, 201205
- Amelogenin Enhances the Osteogenic Differentiation of Mesenchymal Stem Cells Derived from Bone Marrow, CELLS TISSUES ORGANS, 196(5), 411-419, 2012
- A case of mandibular protrusion with temporomandibular joint disorder, 17, 49-59, 20050401
- Occlusion, craniofacial morphology and mandibular kinetic function in a juvenile patient with left facial palsy, 18(1), 29-36, 20060701
- Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase, Archives of Oral Biology, 53(4), 330-336, 20080401
- Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells., Arch Oral Biol, 54(8), 757-763, 20090801
- The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading., Ann Biomed Eng, 37(7), 1358-1367, 20090701
- Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system., Eur J Oral Sci, 118(2), 151-158, 20100401
- Modulation of hyaluronan fragmentation by interleukin-1 beta in synovial membrane cells., Ann Biomed Eng, 38(4), 1618-1625, 20100401
- Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli., J Biomed Mater Res A, 93(1), 373-380, 20100401
- Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes., J Biomed Mater Res A, 92(2), 801-805, 20100201
- Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells., J Biomed Mater Res A, 92(1), 87-93, 20100101
- A treat case of posterior open bite produced by a long-term use of occlusal splint for temporomandibular joint disorders, 42(2), 160-165, 20101201
- Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow, Cell Tissue Res, 342(2), 205-12, 20101101
- Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle., Arch Oral Biol, 56(11), 1412-8, 20111101
- Amelogenin enhances the proliferation of cementoblast lineage cells., J Periodontol, 82(11), 1632-8, 20111101
- Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage., Cell Tissue Res, 344(2), 333-40, 20110501
- Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone., Int J Dent, 20120301
- Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone, International Journal of Dentistry, 352510, 20120401
- Effects of hyaluronan oligosaccharides on apoptosis of human gingival fibroblasts, Open Journal of Stomatology, 3(1), 19-24, 20130301
- Expression of superficial zone protein in mandibular condyle cartilage, OSTEOARTHRITIS AND CARTILAGE, 14(8), 807-813, 200608
- Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase, ARCHIVES OF ORAL BIOLOGY, 53(4), 330-336, 200804
- The effect of mechanical loading on the metabolism of growth plate chondrocytes, ANNALS OF BIOMEDICAL ENGINEERING, 36(5), 793-800, 200805
- Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation, ARCHIVES OF ORAL BIOLOGY, 53(5), 478-487, 200805
- An Adolescent Patient with Multiple Impacted Teeth, ANGLE ORTHODONTIST, 78(6), 1110-1118, 200811
- The Mandibular Cartilage Metabolism is Altered by Damaged Subchondral Bone from Traumatic Impact Loading, ANNALS OF BIOMEDICAL ENGINEERING, 37(7), 1358-1367, 200907
- Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells, ARCHIVES OF ORAL BIOLOGY, 54(8), 757-763, 200908
- Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(1), 87-93, 201001
- Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 92A(2), 801-805, 201002
- Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system, EUROPEAN JOURNAL OF ORAL SCIENCES, 118(2), 151-158, 201004
- Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow, CELL AND TISSUE RESEARCH, 342(2), 205-212, 201011
- Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage, CELL AND TISSUE RESEARCH, 344(2), 333-340, 201105
- Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle, ARCHIVES OF ORAL BIOLOGY, 56(11), 1412-1418, 201111
- Amelogenin Enhances the Proliferation of Cementoblast Lineage Cells, JOURNAL OF PERIODONTOLOGY, 82(11), 1632-1638, 201111
- Synthesis of hyaluronan and superficial zone protein in synovial membrane cells modulated by fluid flow, EUROPEAN JOURNAL OF ORAL SCIENCES, 121(6), 566-572, 201312
- Effects of Low-Intensity Pulsed Ultrasound on the Expression of Cyclooxygenase-2 in Mandibular Condylar Chondrocytes, JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, 28(3), 261-268, 2014
- ★, Effects of Enzymatic Degradation after Loading in Temporomandibular Joint, JOURNAL OF DENTAL RESEARCH, 94(2), 337-343, 201502
- Experimental Tooth Movement Into New Bone Area Regenerated by Use of Bone Marrow-Derived Mesenchymal Stem Cells, CLEFT PALATE-CRANIOFACIAL JOURNAL, 52(4), 386-394, 201507
- Craniofacial Growth and Orthodontic Treatment of Cleft Lip and Palate Patient with Furlow's Method for Soft Palate Repair in Two-stage Palatoplasty, 45(2), 105-111, 2013
- Current status of temporomandibular joint disorders and the therapeutic system derived from a series of biomechanical, histological, and biochemical studies., APOS Trends in Orthodontics, 58-75
- The C-terminus of the amelogenin peptide influences the proliferation of human bone marrow mesenchymal stem cells, JOURNAL OF PERIODONTOLOGY, 89(4), 496-505, 201804
- Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, MEDIATORS OF INFLAMMATION, 2018
- Hyaluronan enhances proteoglycan4 expression in synovial cells, Archives of Medical Research, 5(2), 201701
- Cyclic Tensile Strain Upregulates Pro-Inflammatory Cytokine Expression Via FAK-MAPK Signaling in Chondrocytes, INFLAMMATION, 41(5), 1621-1630, 201810
- Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress, CELL BIOLOGY INTERNATIONAL, 44(4), 966-974, 202004
- Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Mediators Inflamm, 2018, 20180408
- FAK inhibition protects condylar cartilage under excessive mechanical stress, ORAL DISEASES, 26(8), 1736-1746, 202011
- ANGPTL2 Induces Synovial Inflammation via LILRB2, INFLAMMATION, 44(3), 1108-1118, 202106
- ANGPTL2 Promotes Inflammation via Integrin alpha 5 beta 1 in Chondrocytes, CARTILAGE, 13(2_SUPPL), 885S-897S, 202112
Invited Lecture, Oral Presentation, Poster Presentation
- Role of Semaphorin3A in endochondral ossification of mandibular condyle, Tsuboi E., Asakawa Y.,
Hirose N., Yanoshita M., Takano M., Nishiyama S., Kubo N., Onishi A., Yamauchi Y., Tanimoto K, The
9th International Orthodontic Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual
Meeting of the Japanese Orthodontic Society, 2020/10/04, Without Invitation, English
- A case of surgical orthodontic treatment for a patient with osteogenesis imperfecta, Takano M., Asakawa
Y., Hirose N., Tsuboi E., Nakatani A., Kunimatsu R., Tanimoto K, The 9th International Orthodontic
Congress, The 12th Asian Pacific Orthodontic Congress, The 79th Annual Meeting of the Japanese
Orthodontic Society, 2020/10/04, Without Invitation, English
- Familial cases with Hyper-IgE syndrome, Oral/maxillofacial features and Orthodontic treatment plan, Yanoshita M., Hirose N., Takano M., Onishi A., Yamauchi Y., Nishiyama S., Kagawa H., Tsuboi E., Kubo
N., Asakawa Y., Tanimoto K, The 9th International Orthodontic Congress, The 12th Asian Pacific
Orthodontic Congress, The 79th Annual Meeting of the Japanese Orthodontic Society (, 2020/10/04, Without Invitation, English
- ANGPTL2 promotes inflammation via integrin a5B1 in chondrocytes, Takano M., Hirose N., Yanoshita
M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y., Tanimoto K, The 32nd Annual Meeting
of the Japanese Society for Temporomandibular Joint, The 6th Asian Academy congress
for Temporomandibular Joint, 2019/07/27, Without Invitation, Japanese
- Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture
model, Yanoshita M., Hirose N., Takano M., Nishiyama S., Onishi A., Yamauchi Y., Tsuboi E., Asakawa
Y., Tanimoto K, The 32nd Annual Meeting of the Japanese Society for Temporomandibular Joint, The 6th
Asian Academy congress for Temporomandibular Joint, 2019/07/17, Without Invitation, Japanese
- Anti - inflammatory effects of FAK inhibitor on condylar cartilage under excessive mechanical stress, Yanoshita M., Hirose N., Takano M., Sumi C., Nishiyama S., Tsuboi E., Asakawa Y., Onishi A., Yamauchi
Y., Tanimoto K, : The 97th General Session of International Association for Dental Research, 2019/06/19, Without Invitation, English
- Semaphorin3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress, Hirose N.,
Sumi C., Yanoshita M., Takano M., Nishiyama S., Tsuboi E., Onishi A., Yamauchi Y., Asakawa Y.,
Tanimoto K, The 97th General Session of International Association for Dental Research, 2019/06/19, Without Invitation, English, Vancouver
- Effects of Low molecular weight hyaluronan on the expression of PRG4 through CD44 in synovial membrane cells, Mitsuyoshi T, Asakawa Y, Hirose N, Okamoto Y, Yanoshita M, Tanne K, Tanimoto K, 8th international orthodontic congress, 2015/09, Without Invitation, Japanese, published
- Effects of human full length amelogenin on the proliferation of human osteoblasts, Kunimatsu R, Yoshimi Y,Awada T,Asakawa Y,Hirose N,Mitsuyoshi T, Sumi K, Gunji h, Tsuka Y, Tanne K, Tanimoto K, The 74th Annual Meeting of the Japanese Orthodontic Society, 2015/11/18, Without Invitation, English, Fukuoka, preprint
- ANGPTL2 promotes inflammation in chondrocytes, 2019/07/27, Without Invitation, Japanese
- Effects of FAK inhibitor on condylar cartilage under the excessive mechanical stress in organ culture model, 2019/07/27, Without Invitation, Japanese
- Clinical survey on the association between root resorption incident to orthodontic treatment and host factors, 2018/07/07, Without Invitation, Japanese
Awards
- The Encouragement Award of the Japanese Orthodontic Society, Longitudinal effects of estrogen on mandibular growth and changes in cartilage during the growth period in rats
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, 2022, 2024
- KAKENHI, 2013, 2014
- KAKENHI, Elucidation of condylar cartilage resorption mechanism in TMJ-osteoarthritis and search of a new regulatory factor., 2011, 2013
- KAKENHI, Optimization of bone regeneration by use of mesenchymal stem cells and its application for closure of jaw cleft, 2011, 2013
- KAKENHI, Investigation of the mechanism of cartilage destruction induced by COX-2 in temporomandibular joint osteoarthrosis and establishment of anti-inflammatory drug treatment, 2011, 2012
- KAKENHI, Effects of low-intensity ultrasound stimulation osteoarthritis, 2010, 2012
- KAKENHI, Applications of amelogenin to the induction of bone regeneration by using mesenchymal stem cells, 2009, 2010
- 2017/10/02
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020
Social Activities
Organizing Academic Conferences, etc.
- 2021/02, 2021/03