Takashi Ishino

Last Updated :2025/04/03

Affiliations, Positions
Hiroshima University Hospital(Medical), Associate Professor or Lecturer
E-mail
tishinohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2016/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1999/04, 2003/03
  • Hiroshima University, Faculty of Medicine, medicine, Japan, 1991/04, 1997/03

Academic Degrees

  • Ph.D., Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Otorhinolaryngology

Research Keywords

  • cochlear implant
  • allergy
  • hereditary
  • hearing loss

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Human genetics
  2. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment II
  3. 2025, Undergraduate Education, Intensive, Practice for medical research
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  6. 2025, Undergraduate Education, 2Term, Otorhinology
  7. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  8. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  9. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery
  10. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery

Research Activities

Academic Papers

  1. Identification of a novel nonsense NOG mutation in a patient with stapes ankylosis and symphalangism spectrum disorder, HUMAN GENOME VARIATION, 10(1), 20230413
    Link to Paper Search Results by DOI
  2. Severe multiple simultaneous immune-related adverse events in a patient with head and neck cancer, AURIS NASUS LARYNX, 50(2), 309-313, 202304
    Link to Paper Search Results by DOI
  3. Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan, HUMAN GENETICS, 141(3-4), 865-875, 202204
    Link to Paper Search Results by DOI
  4. Functional Alteration and Differential Expression of the Bitter Taste Receptor T2R38 in Human Paranasal Sinus in Patients with Chronic Rhinosinusitis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(5), 202303
    Link to Paper Search Results by DOI
  5. Swallowing function after transoral surgery for laryngopharyngeal cancer, PLOS ONE, 17(6), 20220630
    Link to Paper Search Results by DOI
  6. Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(21), 202211
    Link to Paper Search Results by DOI
  7. Effectiveness of Expanded Instantaneous Input Dynamic Range Adjustment on Speech Perception, JOURNAL OF PERSONALIZED MEDICINE, 12(11), 202211
    Link to Paper Search Results by DOI
  8. Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era, ATMOSPHERE, 13(7), 202207
    Link to Paper Search Results by DOI
  9. A long survival patient of anaplastic thyroid carcinoma treated with lenvatinib, AURIS NASUS LARYNX, 49(3), 515-519, 202006
    Link to Paper Search Results by DOI
  10. ★, Distinct Gene Set Enrichment Profiles in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Bulk RNA Barcoding and Sequencing, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(10), 202205
    Link to Paper Search Results by DOI
  11. A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor, ACTA MEDICA OKAYAMA, 76(2), 229-233, 202204
  12. Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 36(3), 313-322, 202205
    Link to Paper Search Results by DOI
  13. Analysis of syndecan-1 and TGF-beta expression in the nasal mucosa and nasal polyps, AURIS NASUS LARYNX, 37(4), 427-435, 201008
    Link to Paper Search Results by DOI
  14. Syringoid eccrine carcinoma of external auditory canal. A case report, AURIS NASUS LARYNX, 37(4), 519-521, 201008
    Link to Paper Search Results by DOI
  15. Expression and distribution of glucocorticoid receptor isoforms in eosinophilic chronic rhinosinusitis, AURIS NASUS LARYNX, 37(6), 700-707, 201012
    Link to Paper Search Results by DOI
  16. Human osteoclast maturation from bone marrow cells co-cultured with osteoblast from ethmoid sinus, Rhinology, 41, 49-53, 20030401
  17. Establishment of osteoblast culture from human ethmoidal sinus, Auris Nasus Larynx, 30, 45-51, 20030401
  18. Study of Eosinophil Activation in Nasal Mucosa in Patients with Perennial Nasal Allergy:Effects of CO2 Laser Surgery, American Journal of Rhinology, 16, 1-6, 20020401
  19. Laser Surgery of the Inferior Turbinate for Allergic Rhinitis with Seasonal Exacerbation:an Acoustic Rhinometry Study, 112(5), 455-460, 20030501
  20. Comparison of local cytokine gene expression and the distribution of eosinophils and CD4-positive cell subsets in the paranasal sinus mucosa between atopic and non-atopic subjects, Allergology International, 53, 135-144, 20040401
  21. Bone constructing cells from ethmoid bone may have multilineage differentiation potential ? Preliminary report ?, acta otolaryngologica, 553(1-4), 20040503
  22. CHANGES IN VOICE-ONSET TIME DUE TO AUDITORY FEEDBACK THROUGH A COCHLEAR IMPLANT IN THE POST-LINGUAL DEAF, asian pacific symposium on cochlear implants and related scienses, 20051128
  23. Bilateral allergic fungal rhinosinusitis caused by Schizophillum commune and Aspergillus niger. A case report, RHINOLOGY, 47(2), 217-221, 20090601
  24. Glucocorticoids suppress NF-kappa B activation induced by LPS and PGN in paranasal sinus epithelial cells, RHINOLOGY, 47(4), 413-418, 20091201
  25. The First Case of Septicemia Caused by Imipenem-Susceptible, Mreopenem-Resistant Klebsiella pnerumoniae, Annals of Laboratory Medicine, 33(5), 383-5, 20131001
  26. Study of eosinophil activation in nasal mucosa in patients with perennial nasal allergy: Effects of CO2 laser surgery, AMERICAN JOURNAL OF RHINOLOGY, 16(1), 1-6, 2002
    Link to Paper Search Results by DOI
  27. Establishment of osteoblast culture from human ethmoidal sinus, AURIS NASUS LARYNX, 30(1), 45-51, 200302
    Link to Paper Search Results by DOI
  28. Human osteoclast maturation from bone marrow cells co-cultured with osteoblast from ethmoid sinus, RHINOLOGY, 41(1), 49-53, 200303
    Link to Paper Search Results by DOI
  29. Laser surgery of the inferior turbinate for allergic rhinitis with seasonal exacerbation: An acoustic rhinometry study, ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 112(5), 455-460, 200305
    Link to Paper Search Results by DOI
  30. Bone-constructing cells from ethmoid bone may have multilineage differentiation potential: Preliminary report, ACTA OTO-LARYNGOLOGICA, 124, 105-108, 200408
    Link to Paper Search Results by DOI
  31. Submucous turbinectomy combined with posterior nasal neurectomy in the management of severe allergic rhinitis: Clinical outcomes and local cytokine changes, AURIS NASUS LARYNX, 34(3), 319-326, 200709
    Link to Paper Search Results by DOI
  32. Vitamin D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones, RHINOLOGY, 45(3), 208-213, 200709
    Link to Paper Search Results by DOI
  33. Expression of Trefoil factor family peptides in the nasal allergic mucosa, RHINOLOGY, 50(4), 408-416, 201212
    Link to Paper Search Results by DOI
  34. Comparison of Nasal Nitric Oxide Levels between the Inferior Turbinate Surface and the Middle Meatus in Patients with Symptomatic Allergic Rhinitis, ALLERGOLOGY INTERNATIONAL, 63(3), 475-483, 201409
    Link to Paper Search Results by DOI
  35. ★, Novel NOG mutation in Japanese patients with stapes ankylosis with broad thumbs and toes, EUROPEAN JOURNAL OF MEDICAL GENETICS, 58(9), 427-432, 201509
    Link to Paper Search Results by DOI
  36. Comparison of arginase isoform expression in patients with different subtypes of chronic rhinosinusitis, JOURNAL OF LARYNGOLOGY AND OTOLOGY, 129(12), 1194-1200, 201512
    Link to Paper Search Results by DOI
  37. IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 46, 20170502
    Link to Paper Search Results by DOI
  38. Influence of pneumococcal conjugate vaccines on acute otitis media in Japan, AURIS NASUS LARYNX, 45(4), 718-721, 201808
    Link to Paper Search Results by DOI
  39. Vitamin D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones, RHINOLOGY, 45(3), 208-213, 2007
  40. ★, Effects of Cerebral Blood Flow and Vessel Conditions on Speech Recognition in Patients With Postlingual Adult Cochlear Implant: Predictable Factors for the Efficacy of Cochlear Implant, EAR AND HEARING, 39(3), 540-547, 2018
    Link to Paper Search Results by DOI
  41. Frequency and clinical features of hearing loss caused by STRC deletions, SCIENTIFIC REPORTS, 9, 20190313
    Link to Paper Search Results by DOI
  42. OTOF mutation analysis with massively parallel DNA sequencing in 2,265 Japanese sensorineural hearing loss patients, PLOS ONE, 14(5), 20190516
    Link to Paper Search Results by DOI
  43. Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis: A prospective study, AURIS NASUS LARYNX, 46(4), 507-512, 201908
    Link to Paper Search Results by DOI
  44. Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report, AURIS NASUS LARYNX, 46(5), 813-817, 201910
    Link to Paper Search Results by DOI
  45. The Prevalence and Clinical Characteristics of TECTA-Associated Autosomal Dominant Hearing Loss, GENES, 10(10), 201910
    Link to Paper Search Results by DOI
  46. Baseline neutrophil-to-lymphocyte ratio (NLR) is associated with clinical outcome in recurrent or metastatic head and neck cancer patients treated with nivolumab, ACTA OTO-LARYNGOLOGICA, 140(2), 181-187, 20200201
    Link to Paper Search Results by DOI
  47. A Case Report of a Japanese Boy with Morquio A Syndrome: Effects of Enzyme Replacement Therapy Initiated at the Age of 24 Months, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(3), 202002
    Link to Paper Search Results by DOI
  48. Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps, DIAGNOSTICS, 10(4), 202004
    Link to Paper Search Results by DOI
  49. Prevalence and clinical features of hearing loss caused by EYA4 variants, SCIENTIFIC REPORTS, 10(1), 20200227
    Link to Paper Search Results by DOI
  50. Baseline Neutrophil-to-Lymphocyte Ratio and Glasgow Prognostic Score are Associated with Clinical Outcome in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Treated with Nivolumab, ACTA MEDICA OKAYAMA, 75(3), 335-343, 202106
  51. ★, Identification of a Novel Copy Number Variation of EYA4 Causing Autosomal Dominant Non-syndromic Hearing Loss, OTOLOGY & NEUROTOLOGY, 42(7), E866-E874, 202108
    Link to Paper Search Results by DOI
  52. The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 202107
    Link to Paper Search Results by DOI
  53. Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitis, JOURNAL OF LARYNGOLOGY AND OTOLOGY, 135(9), 773-778, 202109
    Link to Paper Search Results by DOI
  54. Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis, EUROPEAN JOURNAL OF INFLAMMATION, 20, 20220101
    Link to Paper Search Results by DOI
  55. Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan, LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, 7(1), 259-265, 202202
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Distinct gene set enrichment profiles in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps., Takashi Ishino, The 61st Annual Meeting of Japanese Rhinologic Society, 2022/10/13, Without Invitation, Japanese
  2. Combination flap technique for choanal atresia, Takashi Ishino, Daisuke Takahara, Yuichiro Horibe, Kota Takemoto, Manabu Nishida, Takashi Oda, Sachio Takeno, 20th Asian Research Symposium in Rhinology, 2021/09/23, Without Invitation, Japanese
  3. Association among speech perception ability with cochlear implant, brain blood supply and FMD, Takashi Ishino, Tohru Sonoyama, Mariko Ueasa, Akiko Yoshimura, Yuka Nagano, Katsuhiro Hirakawa, The 61st congress of Japan audiological society, 2016/10/19, Without Invitation, Japanese, Japan audiological society, Iwate, Association between speech perception ability and FMD was recognized under cochlear implantation.
  4. Transseptal surgery for congenital choanal atresia with Treacher-Collins syndrome, Takashi Ishino, Sachio Takeno, Katsuhiro Hirakawa, The 55th annual meeting of the Japanese rhinologic society, 2016/10/13, Without Invitation, Japanese, Japanese rhinologic society, Gunma, Experience report for transseptal surgery for congenital choanal atresia with Treacher-Collins syndrome
  5. Allergy-associate disease in middle ear and upper airway and its clinical therapy, Takashi Ishino, An Allergy meeting of higashi-hiroshima, 2016/06/21, With Invitation, Japanese, An Allergy meeting of higashi- hiroshima, Hiroshima, Demography of allergy associate disease in middle ear and upper air way and its clinical therapy were demonstrated.
  6. Basic knowledge of hearing disturbance, Takashi Ishino, The education lecture for precis writing by hearing disturbance community, 2016/06/11, With Invitation, Japanese, Hiroshima hearing disturbance community, Hiroshima, Basic knowledge of hearing disturbance
  7. Novel NOG mutation in Japanese familial pedigree with congenital stapes ankylosis, Takashi Ishino, Tohru Sonoyama, Sachio Takeno, Katsuhiro Hirakawa, 117th Annual Meeting of ORL Society of Japan, 2016/05/18, Without Invitation, Japanese, ORL Society of Japan, Nagoya
  8. Expression of interleukin (IL)-18 and IL-33 in human bronchial epithelial cells under gastric acid stimulation, Takashi Ishino, Yutaka Okabayashi Sachio Takeno Katsuhiro Hirakawa, 35th annual meeting of Japanese Association for Airway Secretion Research, 2016/04/23, Without Invitation, Japanese, Japanese Association for Airway Secretion Research, Mie, IL-18 and IL-33 expression were recognized in human airway epithelial cells with gastric acid stimulation.
  9. Front line in hearing therapy Introduction of artificial hearing devices, Takashi Ishino, 3rd open seminar for Hiroshima citizen, 2016/04/09, Without Invitation, Japanese, Hiroshima University, Hiroshima, Introduction of artificial hearing devises
  10. The clinical therapy for the sleep apnea syndrome, Takashi Ishino, The fall congress meeting of Yamaguchi pediatric community, 2015/11/05, With Invitation, Japanese, Yamaguchi pediatric community, Yamaguchi, Clinical therapy for the sleep apnea syndrome
  11. The new cochlear implant programming reflected to the distribution of vowel formant frequency, Takashi Ishino, Akiko Yoshimura, Hiroki Iwai, Mariko Ueasa, Yuka Nagano, Sachio Takeno, Katsuhiro Hirakawa, The 60th Congress of Japan Audiological society, 2015/10/22, Without Invitation, Japanese, Japan audiological society, Tokyo, Effectiveness of new cochlear implant programming
  12. A case report of severe intraoperative bleeding caused by iatrogenic rupture of petrosquamous sinus., Takashi Ishino, Takeno Sachio, Keishin Go, Katsuhiro Hirakawa, The 25th annual meeting of the Japan otological society, 2015/10/07, Without Invitation, Japanese, Japan otological society, Nagasaki, A case report of excessive bleeding from iatrogenic rupture of peterosquamousal sinus was demonstrated.
  13. Resistant factors in rhinosinusitis GERD and LPRD: Epidemiology and the association between cell damage and IL-33, Takashi Ishino, The 54th Annual Meeting of the Japanese Rhinologic Society, 2015/10/02, With Invitation, Japanese, Japanese Rhinologic Society, Hiroshima, Association between rhinosinusitis and GERD and/or LPRD was demonstrated. 　
  14. Cochlear implant and music, Takashi Ishino, 2nd open seminar for Hiroshima citizen, 2015/07/25, Without Invitation, Japanese, Hiroshima University, Hiroshima, Capability of listening to the music in cochlear implant was demonstrated.
  15. Resent topics in cochlear implant, Takashi Ishino, Annual congress of Hiroshima prefectural ACITA community, 2015/06/27, With Invitation, Japanese, Hiroshima prefectural ACITA community, Hiroshima, Recent topics of cochlear implant
  16. Enlarged vestibular aqueduct with SLC26A4 heterozygous mutation., Takashi Ishino, Katsuhiro Hirakawa, 10th annual congress of Japan pediatric otorhinolaryngology society, 2015/05/08, Without Invitation, Japanese, Japan pediatric otorhinolaryngology society, Nagano, Genetic mutation in a patient with enlarged vestibular acqueduct was detected.
  17. IL-33 production in upper airway epithelial cells induced by gastric acid exposure, Takashi Ishino, M.D., Ph.D. Sachio Takeno, M.D., Ph.D. Katsuhiro Hirakawa, M.D., Ph.D., 49th Annual Congress of Korean Rhinologic Society, 2015/03/06, With Invitation, English, Korean Rhinology Society, Korea Busan
  18. IL-33 production induced by gastric acid stimulation in upper airway epithelial cells, Takashi Ishino, Katsuhiro Hirakawa, Sachio Takeno, 49th Annual Congress of Korean Rhinologic Society, 2015/03/06, With Invitation, English, Korean Rhinologic Society, Busan, Detection of IL-33 production was recognized under gastric stimulation in human epithelial cells.
  19. Easy recognition in cochlear implant, Takashi Ishino, Conference of Hiroshima acquired hearing loss community, 2015/02/22, With Invitation, Japanese, Hiroshima acquired hearing loss community, Hiroshima, Detail and mechanism of cochlear implant
  20. Medication therapy for rhinosinusitis., Takashi Ishino, Hiroshima total clinical research, 2015/02/07, With Invitation, Japanese, Hiroshima, Summary for the medical therapy for rhinosinusitis

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2006, 2007
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Social Activities

History as Peer Reviews of Academic Papers

  1. 2017, Acta Oto-laryngologica, Others, reviewer, 1
  2. 2015, International Journal of Otorhinolaryngology, Others, reviewer, 1
  3. 2018, Journal of Otology & Rhinology, Others, 2
  4. 2018, SN Comprehensive Clinical Medicine, Others, 1