MASAFUMI NODA

Last Updated :2022/08/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Associate Professor (Special Appointment)
E-mail
belhiroshima-u.ac.jp
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima, Japan
TEL : (+81)82-257-5288 FAX : (+81)
Self-introduction
under construction

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2010/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Contributing Assistant Professor
  • 2010/04/01, 2012/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Lecturer (Special Appointment)
  • 2012/04/01, Hiroshima University, Institute of Biomedical & Health Sciences, Lecturer (Special Appointment)
  • 2005/04/01, 2006/03/31, Hiroshima University, Researcher
  • 2006/04/01, 2007/03/31, Hiroshima University, Researcher
  • 2016/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate professor (Special Appointment)
  • 2017/04/01, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor (Special Appointment)

Educational Backgrounds

  • Hiroshima University, 1996/04, 2000/03
  • Hiroshima University, 2000/04, 2002/03
  • Hiroshima University, 2002/04, 2005/03

Academic Degrees

  • Doctor of Philosophy in Medical Bioscience, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Natural medicines

Research Keywords

  • molecular microbiology
  • probiotics
  • preventative medicine

Affiliated Academic Societies

  • The Society for Biotechnology, Japan, 2004
  • The Pharmaceutical Society of Japan, 2006
  • Japan Society for Lactic Acid Bacteria, 2007
  • Japanese Society for Bacteriology, 2008
  • The Japanese Society of Clinical Studies on Intestinal Microflora , 2013
  • Japanese Society for Food Hygene and Safety, 2018

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, First Semester, Clinical food science
  2. 2022, Undergraduate Education, First Semester, Practice for clinical food science

Research Activities

Academic Papers

  1. ★, The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217
  2. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
  3. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 201207
  4. Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 201304
  5. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
  6. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
  7. ★, Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46153-46161, 20041029
  8. ★, Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae - Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46143-46152, 20041029
  9. ★, A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
  10. Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
  11. ★, Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
  12. ★, Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
  13. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
  14. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
  15. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
  16. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
  17. ★, Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
  18. ★, Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
  19. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
  20. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
  21. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 201311
  22. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
  23. Aspergillus oryzae S-03 produces gingipain inhibitors as a virulence factor for Porphyromonas gingivalis, Journal of Bacteriology and Virology, 44, 152-161, 2014
  24. ★, Oral lactic acid bacteria that are concerned with the occurrence and/or progression of dental caries in Japanese preschool children., Bioscience of Microbiota, Food and Health, 34, 29-36, 2015
  25. ★, Characterization and mutational analysis of a novel two-polypeptide bacteriocin produced by a Citrus iyo-derived Lactobacillus brevis 174A, Biological & Pharmaceutical Bulletin, 38, 1902-1909, 2015
  26. High-Level Heterologous Production of D-Cycloserine by Escherichia coli, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(22), 7881-7887, 201511
  27. Characterization and Mutational Analysis of a Two-Polypeptide Bacteriocin Produced by Citrus Iyo-Derived Lactobacillus brevis 174A, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(12), 1902-1909, 201512
  28. ★, Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 70(5), 582-587, 201605
  29. Quantifying Parkinson's disease finger-tapping severity by extracting and synthesizing finger motion properties, MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 54(6), 953-965, 201606
  30. ★, Characterization of the LP28 strain-specific exopolysaccharide biosynthetic gene cluster found in the whole circular genome of Pediococcus pentosaceus., Biochem. Biophys. Rep., 5, 266-271, 2016
  31. Crystallographic and mutational analyses of cystathionine beta-synthase in the H2S-synthetic gene cluster in Lactobacillus plantarum, PROTEIN SCIENCE, 26(4), 763-783, 201704
  32. ★, Characterization of Exopolysaccharides Produced by Thermophilic Lactic Acid Bacteria Isolated from Tropical Fruits of Thailand, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(5), 621-629, 201705
  33. ★, Expression of Genes Involved in Bacteriocin Production and Self-Resistance in Lactobacillus brevis 174A Is Mediated by Two Regulatory Proteins, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84(7), 201804
  34. ★, Characterization of the SN35N Strain-Specific Exopolysaccharide Encoded in the Whole Circular Genome of a Plant-Derived Lactobacillus plantarum, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41(4), 536-545, 201804
  35. ★, A novel structure of exopolysaccharide produced by a plant-derived lactic acid bacterium Lactobacillus paracasei IJH-SONE68, JOURNAL OF BIOCHEMISTRY, 164(2), 87-92, 201808
  36. Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis, MOLECULES, 24(16), 201908
  37. Development of a System of High Ornithine and Citrulline Production by a Plant-Derived Lactic Acid Bacterium, Weissella confusa K-28, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(9), 1581-1589, 201909
  38. Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human., The Journal of Antibiotics, 72, 834-842, 2019
  39. Improvement of Alcohol-Poisoning Symptoms in Mice by the Oral Administration of Live Lactobacillus plantarum SN13T Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(5), 202003
  40. Interleukin-8 Release Inhibitors Generated by Fermentation ofArtemisia princepsPampanini Herb Extract WithLactobacillus plantarumSN13T, FRONTIERS IN MICROBIOLOGY, 11, 20200603
  41. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
  42. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 2013
  43. Catalytic specificity of the Lactobacillus plantarum cystathionine gamma-lyase presumed by the crystallographic analysis., Sci Rep., 10, 14886, 2020
  44. Anti-Oxidant and Anti-Inflammatory Substance Generated Newly in Paeoniae Radix Alba Extract Fermented with Plant-Derived Lactobacillus brevis 174A, ANTIOXIDANTS, 10(7), 202107
  45. Lactobacillus reuteri BM53-1 Produces a Compound That Inhibits Sticky Glucan Synthesis by Streptococcus mutans, MICROORGANISMS, 9(7), 202107
  46. Production of Functional Buttermilk and Soymilk Using Pediococcus acidilactici BD16 (alaD(+)), MOLECULES, 26(15), 202108

Invited Lecture, Oral Presentation, Poster Presentation

  1. A hydroxylation reaction necessary in the biosynthesis of an antitubercular antibiotic D-cycloserine, Kumagai, T., Takagi, K., Noda, M., Oda, K., Matoba, Y., Sugiyama, M., 2011/09/08, Without Invitation, Japanese, Sapporo, Japan
  2. Structure and Function of Alanine Racemase Gene of a D-Cycloserine-producing Microorganism., Sugiyama, M., Noda, M., Kumagai, T., 9th International Symposium on the Genetics of Industrial Microorganisms, 2002/07/01, Without Invitation, English, Gyeongju, Korea
  3. Susceptobility of Target sites for D-Cycloserine (DCS) in DCS-Producing Streptomyces lavendulae, Noda, M., Kawahara, Y., Matoba, Y., Kumagai, T., Sugiyama, M., 13th International Symposium on the Biology of Actinomycetes (ISBA meeting), 2003/12/01, Without Invitation, English, Melbourne, Australia
  4. Transcriptional Regulation of the Secondary Metabolite-encoding Genes Expressed in Streptomyces lavendulae ATCC 11924, Okamoto, T., Noda, M., Kawahara, Y., Takahashi, H., Kumagai, T., Matoba, Y., Sugiyama, M., 10th International Symposium on the Genetics of Industrial Microorganisms, 2006/06/24, Without Invitation, English, Prague, Czech Republic
  5. Crystal Structure of an Immunity Protein Mun-Im Which Contributes to Self-Protection of Bacteriocin-Producing Enterococcus mundtii 15-1A, Jeon, H.-J., Noda, M., Matoba, Y., Kumagai, T., Sugiyama, M., 2008 International Meeting of the Federation of Korean Microbiological Societies, 2008/10/16, Without Invitation, English, Seoul, Korea
  6. Development of an in vitro Method Using the Peyer's Patch for Screening of Lactic Acid Bacteria that Display Excellent Probiotic, Zhao, X., Jin, H., Higashikawa, F., Noda, M., Park, S.-N., Sugiyama, M., 2008 International Meeting of the Federation of Korean Microbiological Societies, 2008/10/16, Without Invitation, English, Seoul, Korea
  7. Cloning and heterologous expression of a D-cycloserine biosynthetic gene cluster from Streptomyces lavendulae ATCC11924, Koyama, Y., Kumagai, T., Noda, M., Matoba, Y., Sugiyama, M., 15th International Symposium on Biology of Actinomycetes, 2009/08/20, Without Invitation, Japanese, Shanghai, China
  8. Biosynthesis of Sulfer-Containing Amino Acids in Lactobacillus plantarum SN35N, Kihara, H., Matoba, Y., Kumagai, T., Noda, M., Higashikawa, F., Sugiyama, M., Asian Conference on Lactic Acid Bacteria 6th, 2011/09/08, Without Invitation, English, Sapporo, Japan
  9. Kinetic and Structural Analyses of Two L-Lactate Dehydrogenases from Enterococcus mundtii 15-1A, Miyasako, M., Matoba, Y., Noda, M., Higashikawa, F., Kumagai, T., Sugiyama, M., Asian Conference on Lactic Acid Bacteria 6th, 2011/09/08, Without Invitation, English, Sapporo, Japan
  10. Correlation of Oral Lactic Acid Bacteria Isolated from Pre-Children with Dental Caries, Shimada, A., Noda, M., Matoba, Y., Kumagai, T., Kozai, K., Sugiyama, M., Asian Conference on Lactic Acid Bacteria 6th, 2011/09/08, Without Invitation, English, Sapporo, Japan
  11. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Carrot Leaf-Derived Lactic Acid Bacterium Enterococcus avium G-15, Noda, M., Tamura, T., Ogura, S., Oda, K., Higashikawa, F., Matoba, Y., Kumagai, T., Sugiyama, M., Asian Conference on Lactic Acid Bacteria 6th, 2011/09/08, Without Invitation, English, Sapporo, Japan
  12. A hydroxylation reaction necessary in the biosynthesis of an antitubercular antibiotic D-cycloserine, Kumagai, T., Takagi, K., Noda, M., Oda, K., Matoba, Y., and Sugiyama, M., IUMS2011, 2011/09/06, Without Invitation, English, Sapporo, Japan
  13. Correlation between lactic acid bacteria isolated from oral cavity of pre-school children and dental caries, Noda, M., Sugiyama, M., The 5th International Symposium for lactic acid bacteria to urge industry-university cooperation, 2012/12/04, Without Invitation, English, Seoul, Korea
  14. Health benefit effects by plant-derived lactic acid bacteria., Noda, M., 2010 International Symposium on "Green and Personalized Foods", 2010/10/27, With Invitation, English, Daegu, Korea
  15. Anti-obesity effect of plant-derived lactic acid bacteria isolated, Noda, M., InnovAsia 2011: Food in the Future, 2011/09/15, With Invitation, English, Bangkok, Thailand
  16. Mechanism for expression of the bacteriocin 174A biosynthetic gene cluster harbored in a plant-derived Lactobacillus brevis., Noda, M., Miyauchi, R., Danshiitsoodol,N., Kumagai, T., Matoba, Y., Sugiyama, M., 5th AFSLAB International Symposium, 2016/11/28, Without Invitation, English, Asian Federation of Societies for Lactic Acid Bacteria, Taipei, Taiwan
  17. Biosurfactant derived from Lactobacillus reuteri BM53-1 inhibits production of TSST-1 by Streptococcus aureus at the transcriptional level, Danshiitsoodol,N., Noda, M., Sugimoto, Y., Sugiyama, M., 5th AFSLAB International Symposium, 2016/11/28, Without Invitation, English, Asian Federation of Societies for Lactic Acid Bacteria, Taipei, Taiwan
  18. Contribution to medicinal science and preventive medicine by the plant-derived lactic acid bacteria, Noda, M., Sugiyama, M., Healthcare & Nutraceuticals seminar, 2018/11/11, With Invitation, English, HIroshima University, Singapore Economic Development Board, Biopolis (one-north), Singapore
  19. Contribution to medicinal science and preventive medicine by using the plant-derived lactic acid bacteria, Masafumi Noda, MIRAI Workshops 2019, Ageing and Innovation., 2019/06/02, With Invitation, English, MIRAI project, Tokyo, Japan

Awards

  1. 2011/09/04, The 14th John M. Kinney Award for General Nutrition, The Nutritional Sciences,Education & Research Fund (NSERF) と国際栄養科学雑誌「Nutrition」との連名

Patented

  1. Patent, KR:10-1214696, 2012/12/14
  2. Patent, JP5413819, 2013/11/22
  3. Patent, 5569710, 2014/07/04
  4. Patent, I461154, 2014/11/21
  5. Patent, 2402431, 2015/05/27
  6. Patent, 10-1660272, 2016/09/21
  7. Patent, 9387228, 2016/07/12

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2020, 2022
  2. KAKENHI, 2013, 2015
  3. KAKENHI, Anti-obesity mechanism of Pediococcus pentosaceus LP28 and its effect in overweight subjects, 2011, 2013
  4. KAKENHI, Characterization of biosynthetic and self-protection mechanisms on novel bacteriocin produced by plant-derived LAB strain 174A, 2010, 2012
  5. KAKENHI, Characterization of novel regulatory system for the bacteriocin biosynthesis, 2008, 2009
  6. KAKENHI, 2016, 2018

Social Activities

Organizing Academic Conferences, etc.

  1. 2014/07, 2014/07

History as Peer Reviews of Academic Papers

  1. 2021, Sustainability, Others, reviewer, 1
  2. 2021, Molecules, Others, reviewer, 1
  3. 2021, Microorganisms, Others, reviewer, 1
  4. 2021, Food Bioscience, Others, reviewer, 1
  5. 2021, International Journal of Molecular Sciences, Others, reviwer, 1
  6. 2021, Plants, Others, reviwer, 1
  7. 2021, Journal of Microbiology, Others, reviewer, 1
  8. 2021, FEMS Microbiology Letters, Others, reviewer, 1
  9. 2021, Allergies, Others, reviewer, 1
  10. 2021, Journal of Biotechnology, Others, reviewer, 1
  11. 2020, Food Bioscience, Others, reviewer, 1
  12. 2020, Journal of Bioscience and Bioengineering, Others, reviewer, 2
  13. 2020, Bioscience of Microbiota, Food and Health, Others, reviewer, 1
  14. 2020, International Immunopharmacology, Others, reviewer, 1
  15. 2019, Bioscience of Microbiota, Food and Health, Others, reviewer, 1
  16. 2019, Journal of Bioscience and Bioengineering, Others, reviewer, 2
  17. 2017, Applied Microbiology and Biotechnology, Others, reviewer, 1
  18. 2017, Journal of Bioscience and Bioengineering, Others, reviewer, 1
  19. 2016, Applied Biochemistry and Biotechnology, Others, reviewer, 1
  20. 2016, Journal of Diabetes Research, Others, reviewer, 1
  21. 2016, Bioscience of Microbiota, Food and Health, Others, reviewer, 1
  22. 2016, Journal of Bioscience and Bioengineering, Others, reviewer, 1
  23. 2015, Journal of Applied Microbiology, Others, reviewer, 1
  24. 2014, Applied Biochemistry and Biotechnology, Others, reviewer, 2
  25. 2012, Applied Biochemistry and Biotechnology, Others, reviewer, 1