RYUICHI HIROTA

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
hirotahiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2007/03/01, 2017/05/31, Hiroshima University Graduate School of Advanced Sciences of Matter, Assistant Professor
  • 2013/09/28, 2014/11/28, University of Illinois Urbana-Champaign, Visiting Scholar
  • 2017/06/01, 2019/03/31, Hiroshima University Graduate School of Advanced Sciences of Matter, Associate Professor
  • 2019/04/01, 2024/03/31, Hiroshima University Graduate School of Integrated Sciences for Life, Associate Professor

Academic Degrees

  • Dr. Engineering, Hiroshima University
  • Master of Engineering, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Engineering : Cluster 3(Applied Chemistry, Biotechnology and Chemical Engineering) : Program of Biotechnology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biotechnology

In Charge of Primary Major Programs

  • Biotechnology

Research Fields

  • Agricultural sciences;Agricultural chemistry;Applied microbiology

Research Keywords

  • environmental biotecnology
  • bacteria
  • inorganic phosphorus compounds
  • reduced phosphorus compounds
  • molecular biology

Affiliated Academic Societies

  • American society for microbiology
  • The Society for Biotechnology
  • The Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japan Society for Environmental Biotechnology

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Training of Biotechnology I
  2. 2025, Undergraduate Education, 2Term, Biochemical Engineering
  3. 2025, Undergraduate Education, Year, Graduation Thesis
  4. 2025, Graduate Education (Master's Program) , 3Term, Research Methods in Life Science
  5. 2025, Graduate Education (Master's Program) , Academic Year, Seminar in Biotechnology
  6. 2025, Graduate Education (Master's Program) , 1Term, Exercises in Biotechnology A
  7. 2025, Graduate Education (Master's Program) , 2Term, Exercises in Biotechnology A
  8. 2025, Graduate Education (Master's Program) , 3Term, Exercises in Biotechnology B
  9. 2025, Graduate Education (Master's Program) , 4Term, Exercises in Biotechnology B
  10. 2025, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biotechnology
  11. 2025, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. ★, Cell morphology engineering enhances grazing resistance of Synechococcus elongatus PCC 7942 for non-sterile large-scale cultivation, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 137(4), 245-253, 202404
    Link to Paper Search Results by DOI
  2. Expression of bacterial phosphite dehydrogenase confers phosphite availability in a unicellular red alga Cyanidioschyzon merolae, JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 69(5), 287-291, 2023
    Link to Paper Search Results by DOI
  3. An insight into potential phosphate bioremediation and renewable energy from agricultural waste via integrated wastewater treatment systems in Indonesia, Environmental Research Communications, 6, 042001, 202404
  4. A novel salt- and organic solvent-tolerant phosphite dehydrogenase from Cyanothece sp. ATCC 51142, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 11, 20230818
    Link to Paper Search Results by DOI
  5. ★, Biodiversity risk assessment of genetically modified Chaetoceros gracilis for outdoor cultivation, JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 68(3), 151-162, 2022
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  6. A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria, JOURNAL OF BACTERIOLOGY, 205(5), 20230525
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  7. Assessment of horizontal gene transfer-mediated destabilization of Synechococcus elongatus PCC 7942 biocontainment system, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 135(3), 190-195, 202303
    Link to Paper Search Results by DOI
  8. ★, Biodiversity risk assessment of genetically modified Chaetoceros gracilis for outdoor cultivation, The Journal of General and Applied Microbiology, 68(3), 151-162, 2022
  9. ★, Gatekeeper Residue Replacement in a Phosphite Transporter Enhances Mutational Robustness of the Biocontainment Strategy, ACS SYNTHETIC BIOLOGY, 11(10), 3397-3404, 20221021
    Link to Paper Search Results by DOI
  10. Engineering Cofactor Specificity of a Thermostable Phosphite Dehydrogenase for a Highly Efficient and Robust NADPH Regeneration System, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 9, 20210401
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  11. Phosphite Reduces the Predation Impact of Poterioochromonas malhamensis on Cyanobacterial Culture, Plants, 10(7), 1361, 20210702
  12. Biological Phosphite Oxidation and Its Application to Phosphorus Recycling, Phosphorus Recovery and Recycling, 499-514, 20180326
  13. ★, Synthetic Phosphorus Metabolic Pathway for Biosafety and Contamination Management of Cyanobacterial Cultivation, ACS Synthetic Biology, 20180911
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  14. ★, A Novel Biocontainment Strategy Makes Bacterial Growth and Survival Dependent on Phosphite, SCIENTIFIC REPORTS, 7, 20170320
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  15. A Lactobacillus mutant capable of accumulating long-chain polyphosphates that enhance intestinal barrier function, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(5), 955-961, 201605
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  16. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(39), 12175-12180, 20150929
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  17. ★, Environmental biotechnology for efficient utilization of industrial phosphite waste, Global Environ Res, 19(1), 77-82, 2015
  18. ★, A New Subfamily of Polyphosphate Kinase 2 (Class III PPK2) Catalyzes both Nucleoside Monophosphate Phosphorylation and Nucleoside Diphosphate Phosphorylation, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 80(8), 2602-2608, 201404
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  19. ★, Application of a phosphite dehydrogenase gene as a novel dominant selection marker for yeasts, JOURNAL OF BIOTECHNOLOGY, 182, 68-73, 20140720
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  20. ★, Stable polyphosphate accumulation by a pseudo-revertant of an Escherichia coli phoU mutant, BIOTECHNOLOGY LETTERS, 35(5), 695-701, 201305
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  21. ★, Isolation and characterization of a soluble and thermostable phosphite dehydrogenase from Ralstonia sp strain 4506, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 113(4), 445-450, 201204
    Link to Paper Search Results by DOI
  22. Construction of membrane-anchoring fusion protein of Thermococcus kodakaraensis glycerol kinase and its application to repetitive batchwise reactions, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 113(4), 521-525, 201204
    Link to Paper Search Results by DOI
  23. Synthetic metabolic engineering-a novel, simple technology for designing a chimeric metabolic pathway, MICROBIAL CELL FACTORIES, 11, 20120906
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  24. Overproduction of YjbB reduces the level of polyphosphate in Escherichia coli: a hypothetical role of YjbB in phosphate export and polyphosphate accumulation, FEMS MICROBIOLOGY LETTERS, 320(1), 25-32, 201107
    Link to Paper Search Results by DOI
  25. Feasibility of thermophilic adenosine triphosphate-regeneration system using Thermus thermophilus polyphosphate kinase, PROCESS BIOCHEMISTRY, 46(9), 1747-1752, 201109
    Link to Paper Search Results by DOI
  26. ★, Bacterial phosphate metabolism and its application to phosphorus recovery and industrial bioprocesses, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 109(5), 423-432, 201005
    Link to Paper Search Results by DOI
  27. Production of 2-deoxyribose 5-phosphate from fructose to demonstrate a potential of artificial bio-synthetic pathway using thermophilic enzymes, JOURNAL OF BIOTECHNOLOGY, 148(4), 204-207, 20100802
    Link to Paper Search Results by DOI
  28. ★, The silicon layer supports acid resistance of Bacillus cereus spore, JOURNAL OF BACTERIOLOGY, 20100101
  29. Reciprocating-flow ATP amplification system for increasing the number of amplification cycles, ANALYTICAL BIOCHEMISTRY, 395(2), 161-165, 20091215
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  30. Continuous-Flow ATP amplification system on a chip, SENSORS AND ACTUATORS B-CHEMICAL, 142(1), 118-122, 20091012
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  31. The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways, Nature Cell Biology, 11(3), 312-319, 20090601
  32. Transcriptional Analysis of the Multicopy hao Gene Coding for Hydroxylamine Oxidoreductase in Nitrosomonas sp. Strain ENI-11, Biosci. Biotechnol. Biochem., 1875-1881, 20070823
  33. ★, Use of an Escherichia coli recombinant producing thermostable polyphosphate kinase as an ATP regenerator to produce fructose 1,6-diphosphate, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(17), 5676-5678, 200709
    Link to Paper Search Results by DOI
  34. Turning off estrogen receptor beta-mediated transcription requires estrogen-dependent receptor proteolysis., Molecular and Cellular Biology, 7966-7976, 20060828
  35. ★, Transcriptional analysis of the multicopy hao gene coding for hydroxylamine oxidoreductase in Nitrosomonas sp strain ENI-11, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 70(8), 1875-1881, 200608
    Link to Paper Search Results by DOI
  36. ★, Isolation and characterization of cbbL and cbbS genes encoding form I ribulose-1,5-bisphosphate carboxylase/oxygenase large and small subunits in Nitrosomonas sp strain ENI-11, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(3), 632-635, 200203
    Link to Paper Search Results by DOI
  37. Molecular analysis of the nitrification henes in Nitrosomonas sp. strain ENI-11, Proceedings of 5th International Symposium on Environmental Biotechmology, 67-70, 20010701
  38. ★, Mutational analysis of the multicopy hao gene coding for hydroxylamine oxidoreductase in the ammonia-oxidizing bacterium Nitrosomonas sp. strain ENI-11, Biosc. Biochem. Biotechnol., 64, 1754-1757, 20000401
  39. ★, Physical map location of the multicopy genes coding for ammonia monooxygenase and hydroxylamine oxidoreductase in the ammonia-oxidizing bacterium Nitrosomonas sp strain ENI-11, JOURNAL OF BACTERIOLOGY, 182(3), 825-828, 200002
    Link to Paper Search Results by DOI
  40. Mutational analysis of the multicopy hao gene coding for hydroxylamine oxidoreductase in Nitrosomonas sp strain ENI-11, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 64(8), 1754-1757, 200008
    Link to Paper Search Results by DOI
  41. ★, Isolation and characterization of two cryptic plasmids in the ammonia-oxidizing bacterium Nitrosomonas sp. strain ENI-11, JOURNAL OF BACTERIOLOGY, 181, 3375-3381, 19990401
  42. Biodiversity risk assessment of genetically modified Chaetoceros gracilis for outdoor cultivation, The Journal of General and Applied Microbiology, 20220531