KANA OUE

Last Updated :2026/04/03

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
owen-0428hiroshima-u.ac.jp
Self-introduction
In clinical practice, I provide education, guidance, and research on dental anesthesiology in general. In basic research, I'm conducting research on the effects of obesity and periodontal infections on cognitive function.

Basic Information

Major Professional Backgrounds

  • 2019/04/01, Hiroshima University, Hospital, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical Sciences, Japan, 2010/04, 2015/03
  • Hiroshima University, Faculty of Dentistry, Japan, 2003/04, 2009/03

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry

Research Keywords

  • general anesthesia / energy metabolism / lipolysis / obesity / periodontal disease, periodontitis / neuroinflammation / microglia

Affiliated Academic Societies

  • Japanese Airway Management Society, 2025/03
  • Japanese Society of Orofacial Pain, 2024/02
  • The Japanese Society of Gerodontology, 2023/01
  • The Japan Society for Clinical Anesthesia, 2021/06
  • The Japanese Association for Oral Biology, 2017/04
  • The Japanese Society for Disability and Oral Health, 2016/08
  • the Japanese Society of Anesthesiologists, 2012/05
  • The Japanese Dental Society of Anesthesiology, 2011/04

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, 3Term, Dental Anesthesiology
  2. 2026, Undergraduate Education, 4Term, Basic Seminar of Dental Anesthesiology
  3. 2026, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  4. 2026, Undergraduate Education, First Semester, Dental Research Practices I
  5. 2026, Undergraduate Education, Second Semester, Dental Research Practices II
  6. 2026, Undergraduate Education, 2Term, General Seminar on Clinical Dentistry
  7. 2026, Undergraduate Education, First Semester, Dental Research Practices III
  8. 2026, Undergraduate Education, Year, Clinical Practice (Dental Anesthesiology)
  9. 2026, Undergraduate Education, 4Term, Dental Anesthesiology
  10. 2026, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  11. 2026, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  12. 2026, Undergraduate Education, Intensive, Clinical Practice on Oral Health
  13. 2026, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  14. 2026, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  15. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dental Anesthesiology
  16. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dental Anesthesiology
  17. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dental Anesthesiology
  18. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dental Anesthesiology

Research Activities

Academic Papers

  1. Ketamine-induced pica behavior as nausea and vomiting involves dopamine and serotonin receptor activation in the area postrema of rats: A comparison with etomidate and pentobarbital, EUROPEAN JOURNAL OF PHARMACOLOGY, 1005, 20251015
    Link to Paper Search Results by DOI
  2. Anesthetic Management of a Pregnant Patient Undergoing Oral Surgery, ANESTHESIA PROGRESS, 72(2), 104-108, 202506
    Link to Paper Search Results by DOI
  3. Anesthetic Management for an Elderly Patient with Severe Bronchiectasis, ANESTHESIA PROGRESS, 72(1), 33-36, 202503
    Link to Paper Search Results by DOI
  4. Early prevention of carrageenan-induced peripheral/spinal inflammation suppresses microglial hyperreactivity in the trigeminal spinal subnucleus caudalis and alleviates chronic facial nociception, Heliyon, 11(2), e41602, 202501
    Link to Paper Search Results by DOI
  5. General anesthesia with remimazolam for tooth extraction in a patient with Noonan syndrome and hypertrophic obstructive cardiomyopathy: A case report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 37(1), 108-111, 202501
    Link to Paper Search Results by DOI
  6. Oral administration of Porphyromonas gingivalis to mice with diet-induced obesity impairs cognitive function associated with microglial activation in the brain, JOURNAL OF ORAL MICROBIOLOGY, 16(1), 20241231
    Link to Paper Search Results by DOI
  7. Dental Suction Interference and Acoustic Respiratory Monitoring, ANESTHESIA PROGRESS, 71(4), 171-175, 20241204
  8. Anesthetic management of a patient with Sturge-Weber syndrome in sagittal split ramus osteotomy surgery., CLINICAL CASE REPORTS, 12(4), e8741, 202404
    Link to Paper Search Results by DOI
  9. A case of systemic management for an autism spectrum disorder and dental phobia patient with Fontan circulation, Journal of the Japanese Society for Disability and Oral Health, 45(2), 104-111, 2024
  10. Severe perioperative lactic acidosis in a pediatric patient with glycogen storage disease type Ia: a case report, JA Clinical Report, 9(1), 91, 20231220
    Link to Paper Search Results by DOI
  11. New acoustic monitoring system quantifying aspiration risk during monitored anaesthesia care., Scientific Reports, 13(1), 20196, 20231118
    Link to Paper Search Results by DOI
  12. Efficacy and safety of remimazolam besilate for sedation in outpatients undergoing impacted third molar extraction: a prospective exploratory study, BMC ORAL HEALTH, 23(1), 20231021
    Link to Paper Search Results by DOI
  13. Spinal Muscular Atrophy Type III Recognized After Delayed Recovery From Neuromuscular Blockade After an Orthognathic Surgery, JOURNAL OF CRANIOFACIAL SURGERY, 34(6), e580-e582, 20231006
    Link to Paper Search Results by DOI
  14. Oral surgery under general anesthesia in a patient with catecholaminergic polymorphic ventricular tachycardia: A case report, Oral Science International, 1-5, 20230625
    Link to Paper Search Results by DOI
  15. N-methyl-D-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice, NEUROSCIENCE LETTERS, 802, 20230401
    Link to Paper Search Results by DOI
  16. Analgesia-based Sedation for Oral Surgery in Patients With Chronic Respiratory Obstructive Disease., JOURNAL OF CRANIOFACIAL SURGERY, 31(1), e70-e74, 20230221
    Link to Paper Search Results by DOI
  17. Spinal Muscular Atrophy Type III Recognized After Delayed Recovery From Neuromuscular Blockade After an Orthognathic Surgery, JOURNAL OF CRANIOFACIAL SURGERY, 34(6), E580-E582, 202309
    Link to Paper Search Results by DOI
  18. Usefulness of new acoustic respiratory sound monitoring with artificial intelligence for upper airway assessment in obese patients during monitored anesthesia care, JOURNAL OF MEDICAL INVESTIGATION, 70(3-4), 430-435, 202308
  19. Usefulness of new acoustic respiratory sound monitoring with artificial intelligence for upper airway assessment in obese patients during monitored anesthesia care, The Journal of Medical Investigation, 70(3.4), 430-435, 2023
    Link to Paper Search Results by DOI
  20. Analgesia-based Sedation for Oral Surgery in Patients With Chronic Respiratory Obstructive Disease, JOURNAL OF CRANIOFACIAL SURGERY, 34(1), 2023
    Link to Paper Search Results by DOI
  21. Imipramine prevents Porphyromonas gingivalis lipopolysaccharide- induced microglial neurotoxicity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 634, 92-99, 20221217
    Link to Paper Search Results by DOI
  22. Difficult intubation and postoperative aspiration pneumonia associated with Moebius syndrome: a case report, BMC ANESTHESIOLOGY, 22(1), 20221011
    Link to Paper Search Results by DOI
  23. Pentobarbital may protect against neurogenic inflammation after surgery via inhibition of substance P release from peripheral nerves of rats, NEUROSCIENCE LETTERS, 771, 20220206
    Link to Paper Search Results by DOI
  24. Effects of antipsychotics on intravenous sedation with midazolam and propofol during dental treatment for patients with intellectual disabilities, JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 66(4), 323-331, 202204
    Link to Paper Search Results by DOI
  25. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 8(1), 225-230, 202202
    Link to Paper Search Results by DOI
  26. Efficacy of Chest Compressions Performed on Patients in Dental Chairs Versus on the Floor, Anesthesia progress, 68(2), 85-89, 20210601
  27. Usefulness of Tranexamic Acid Administration During Sagittal Split Ramus Osteotomy, JOURNAL OF CRANIOFACIAL SURGERY, 32(1), 273-276, 2021
    Link to Paper Search Results by DOI
  28. The indirect r-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway, Pharmacology Biochemistry and Behavior, 198, 20200907
  29. A Case of Difficult Ventilation during the Induction of General Anesthesia Because of Bronchospasm, Journal of Japanese Dental Society of Anesthesiology, 48(2), 81-83, 202004
  30. Simultaneous Excision of a Tongue Tumor and a Thoracoscopic Malignant Lung Tumor under General Anesthesia, Journal of Japanese Dental Society of Anesthesiology, 48(1), 19-21, 202001
  31. Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure, JOURNAL OF ORAL BIOSCIENCES, 61(2), 65-72, 201906
    Link to Paper Search Results by DOI
  32. General anesthetic actions on GABA(A) receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice, JOURNAL OF ANESTHESIA, 31(4), 531-538, 201708
    Link to Paper Search Results by DOI
  33. Phospholipase C-related catalytically inactive protein-knockout mice exhibit uncoupling protein 1 upregulation in adipose tissues following chronic cold exposure, JOURNAL OF ORAL BIOSCIENCES, 59(2), 108-112, 201705
    Link to Paper Search Results by DOI
  34. Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation, JAPANESE DENTAL SCIENCE REVIEW, 53(1), 18-24, 201702
  35. Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by -Adrenergic Receptors in Brown Adipocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8), 4185-4196, 201602
    Link to Paper Search Results by DOI
  36. Sodium butyrate ameliorates inflammation-induced depression-like behavior, JOURNAL OF PHARMACOLOGICAL SCIENCES, 128(3), S227-S227, 201507
  37. New molecular basis in the regulation of lipolysis via dephosphorylation., Nihon Yakurigaku Zasshi., 146(2), 93-97, 2015
    Link to Paper Search Results by DOI
  38. Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase, PLOS ONE, 9(6), e100559, 201406
    Link to Paper Search Results by DOI
  39. An Appropriate Compression Pace is Important for Securing the Quality of Hands-only CPR - A manikin study., Hiroshima Journal of Medical Sciences, 63(2), 7-11, 2014

Invited Lecture, Oral Presentation, Poster Presentation

  1. Myofascial pain syndrome after refractory local anesthesia with IV sedation, Imamura S, Doi M, Oue K, Imado E, Sasaki U, Oda A, Kamio H, Suyama M, Shimizu Y, Yoshida M, Hanamoto H, The 53nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2025/10/10, Without Invitation, Japanese, Kagoshima
  2. A case of trigeminal neuralgia in which treatment for myofascial pain improved control, Kamio H, Doi M, Oda A, Imamura S, Sasaki U, Imado E, Suyama M, Kikuchi T, Nishimura Y, Myoken Y, Hanamoto H, The 53nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2025/10/10, Without Invitation, Japanese, Kagoshima
  3. A case of a patient who visited a pain clinic complaining of numbness after tooth extraction and was found to have chronic myofascial pain, Kamio H, Kamio H, Doi M, Yoshida M, Shimizu Y, Oue K, Sasaki U, Imado E, Suyama M, Kikuchi T, Nishimura Y, Myoken Y, Hanamoto H, The 53nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2025/10/10, Without Invitation, Japanese, Kagoshima
  4. Intranasal Midazolam for Premedication in Adults with Intellectual Disabilities, Oue Kana, Oda Y, Sasaki U, Imado E, Kamio H, Suyama M, Kikuchi T, Takahashi T, Imamura S, Oda A, Doi M, Shimizu Y, Yoshida M, Hanamoto H, The 53nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2025/10/10, Without Invitation, Japanese, Kagoshima
  5. Safety Considerations in Sedation-Based Dental Treatment for Pediatric and Special Needs Patients, Oue Kana, The 30th Annual Meeting of the Japanese Society of Pediatric Anesthesiology, 2025/10/04, With Invitation, Japanese, Japanese Society of Pediatric Anesthesiology, Tokushima
  6. Impact of Obesity and Periodontal Disease on Cognitive Function via Microglial Activation, Kana Oue, Rie Kawakami, Hisakazu Ouhara, Hiroshi Hanamoto, Yukio Ago, The 25th Scientific Meeting of the Japanese Association for Dental Scence, 2025/09/26, Without Invitation, Japanese, Yokohama
  7. Analysis of Blood–Brain Barrier Disruption Induced by Periodontal Infection under Obese Conditions, Oue K, Yamawaki Y, Ouhara K, Ago Y, The 67nd Anuual Meeting of the Japanese Association for Oral Biology, 2025/09/05, Without Invitation, Japanese, Kokura
  8. A case of suspected anaphylactic reaction after general anesthesia induction, Suyama M, Yoshida M, Imado E, Sasaki U, Kamio H, Imamura S, Oda A, Oue K, Doi M, Shimizu Y, Hanamoto H, The 39th Scientific Meeting of Dental Anestheology in Chugoku and Shikoku Branch, 2025/07/27, Without Invitation, Japanese, Tokushima
  9. Perioperative Management of a Patient with Severe Motor and Intellectual Disabilities Complicated by Severe Scoliosis: A Case Report, Taro Kikuchi, Oue K,Nishimura Y, Myoken Y, Suyama M, Kamio H, Imado E, Imamura S, Sasaki U, Oda A, Doi M, Shimizu Y, Yoshida M, Hanamoto H, The 39th Scientific Meeting of Dental Anestheology in Chugoku and Shikoku Branch, 2025/07/27, Without Invitation, Japanese, Tokushima
  10. AI-Based Adventitious Sound Classification for Visualization of Aspiration Risk, Itou S, Shimizu Y, Takahashi T, Oda A, Oue K, Yoshida M, Saeki N, Ohshimo S, Hanamoto H, Shime N, The 53nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2025/06/28, Without Invitation, Japanese, Hiroshima
  11. Awake Tracheal Intubation Under Sedation with Remimazolam: Three Case Reports of Difficult Airway Management, KANA OUE, Suyama M, Kikuchi T, Kamio H, Imamura S, Oda A, Doi M, Shimizu Y, Yoshida M, Hanamoto H, The 8th Annual Meeting of Japanese Airway Management Society, 2025/06/28, Without Invitation, Japanese, Japanese Airway Management Society, Hiroshima
  12. Perioperative management of an autistic child with severe obesity and diabetes mellitus who had difficulty following preoperative fasting instructions, Oda A, Oue K, Imado E, Takahashi T, Shimizu Y, Yoshida M, Morimoto M, Yoshida Y, Okada Y, Hanamoto H, The 41st Annual Meeting of the Japanese Society for Disability and Oral Health, 2024/12/13, Without Invitation, Japanese
  13. Intranasal Administration of Midazolam as Premedication in Adolescents and Young Adults with Intellectual Disabilities: A Report of Three Cases, Oue K, Oda Y, Oda A, Takahashi T, Imado E, Shimizu Y, Yoshida M, Okada Y, Hanamoto H, The 41st Annual Meeting of the Japanese Society for Disability and Oral Health, 2024/12/13, Without Invitation, Japanese
  14. A case of masticatory myofascial pain with trismus which was successfully training opening mouth combined trigger point injection, Imamura S, Doi M, Imado E, Sasaki U, Kamio H, Oue K, Yoshida M, Hanamoto H, The 29th Annual Meeting of Japanese Society of Orofacial Pain, 2024/11/30, Without Invitation, Japanese
  15. A case of Paroxysmal Supraventricular Tachycardia during general anesthesia was considered to be indused by sevoflurane, Imamura S, Takahashi T, Oda A, Imado E, Sasaki U, Kamio H, Oue K, Doi M, Shimizu Y, Yoshida M, Hanamoto H, The 52nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2024/10/25, Without Invitation, Japanese
  16. Consideration of discharge approval criteria after dental treatment under intravenous sedation with remimazolam: Oda A, Oue K, Imado E, Sasaki U, Imamura S, Kamio H, Takahashi T, Doi M, Shimizu Y, Yoshida M, Hanamoto H: The 52nd Anuual Meeting of the Japanese, Oda A, Oue K, Imado E, Sasaki U, Imamura S, Kamio H, Takahashi T, Doi M, Shimizu Y, Yoshida M, Hanamoto H, The 52nd Anuual Meeting of the Japanese Dental Society of Anethesiology, 2024/10/25, Without Invitation, Japanese
  17. Meloxicam prevents carrageenan-induced chronic hyperalgesia by suppressing microglial activation, Yoshida M, Yamamoto T, Imado E, Mulpuri Y, Oue K, Kurata S, Doi M, Shimizu Y, Tanaka Y, Kishimoto N, Hanamoto H, Seo K, NEUROSCIENCE2024, 2024/10/05, Without Invitation, English, Chicago
  18. Intranasal midazolam as premedication for anesthesia in patients with intellectual disabilities – Report of three cases, Kana Oue, Aya Oda, Yuki Oda, Eiji Imado, Yuriko Yoshida, Yoshiyuki Okada, Hiroshi Hanamoto, 27th international conference of the International Association for Disability and Oral Health, 2024/09/26, Without Invitation, English, International Association for Disability and Oral Health(iADH), Seoul, South Korea
  19. Consideration of discharge approval criteria after day-case sedation using remimazolam for dental treatment, Aya Oda, Kana Oue, Eiji Imado, Utaka Sasaki, Serika Imamura, Hisanobu Kamio, Tamayo Takahashi, Mitsuru Doi, Yoshitaka Shimizu, Mitsuhiro Yoshida, Hiroshi Hanamoto, 27th international conference of the International Association for Disability and Oral Health, 2024/09/26, Without Invitation, English, International Association for Disability and Oral Health(iADH), Seoul, South Korea
  20. A case of intravenous sedation using acoustic monitoring system for airway management of a patient with myotonic dystrophy, Imamura S, Takahashi T, Shimizu Y, Sasaki U, Imado E, Kamio H, Oda A, Oue K, Doi M, Yoshida M, Hanamoto H, The 38th Scientific Meeting of Dental Anesthesiology in Chugoku and Shikoku Branch, 2024/07/21, Without Invitation, Japanese
  21. A case of reflux esophagitis diagnosed after repeated vomiting during intravenous sedation, Takahashi T, Shimizu Y, Imamura S, Imado E, Sasaki U, Kamio H, Oda A, Oue K, Doi M, Yoshida M, Hanamoto H, The 38th Scientific Meeting of Dental Anesthesiology in Chugoku and Shikoku Branch, 2024/07/21, Without Invitation, Japanese
  22. Oral administration of Porphyromonas gingivalis to diet-induced obese mice impairs cognitive function, Kana Oue, Takuya Suruga, Eiji Imado, Testuya Tamura, Yosuke Yamawaki, Kazuhisa Ouhara, Hiroshi Hanamato, Yukio Ago, 34th Annual Congress of the European College of Gerodontology, 2024/06/06, Without Invitation, English, EUROPEAN COLLEGE OF GERODONTOLOGY, Serbia
  23. Meloxicam Prevents Carrageenan-induced Chronic Hyperalgesia and Microglial Activation, Yoshida M, Yamamoto T, Imado E, Koyama Y, Mulpuri Y, Imamura S, Kamio H, Oda A, Takahashi T, Imai Y, Ujita T, Sawada E, Oue K, Kishimoto N, Seo K, 2024 IADR/AADOCR/CADR General Session & Exhibition, 2024/03/13, Without Invitation, English, New Orleans
  24. Periodontal infection in diet-induced obesity causes cognitive impairment associated with microglial activation., Kana Oue, Kana Oue, Yusuke Morioka, Eiji Imado, Testuya Tamura, Yosuke Yamawaki, Kazuhisa Ouhara, Mitsuhiro Yoshida, Takashi Kanematsu, Yukio Ago., IAGG Asia/Oceania Regional Congress 2023, 2023/06/14, Without Invitation, English, International Association of Gerontology and Geriatrics, Yokohama
  25. Investigation of the mechanism of cognitive dysfunction induced by periodontal infection under obesity., Oue Kana, Yamawaki Yosuke, Kanematsu Takashi, 2021/10, Without Invitation, Japanese, Yokohama
  26. Difficult intubation and postoperative aspiration pneumonia associated with Moebius syndrome: case report, Aya Oda, Kana Oue, Yuki Oda, Akari Mukai, Mituru Doi, Yoshitaka Shimizu, Mitsuhiro Yoshida, Masahiro Irifune, The ANESTHESIOLOGY annual meeting, 2021/10, Without Invitation, English, American Society of Anesthesiologists, San Diego

External Funds

Acceptance Results of Competitive Funds

  1. Grants-in-Aid for Scientific Research, Mechanisms of the Interaction of Obesity Pathology and Periodontal Infection on Cognitive Function, 2023/04/01, 2026/03/31
  2. Grants-in-Aid for Scientific Research, 2020/04/01, 2023/03/31
  3. Grants-in-Aid for Scientific Research, 2017/04/01, 2020/03/31
  4. Grants-in-Aid for Scientific Research, 2015/08/28, 2017/03/31