HIROSHI OUE

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
hiroshi-ohiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5677 FAX : (+81)82-257-5679
Self-introduction
Prosthodontics

Basic Information

Educational Backgrounds

  • Hiroshima University, Japan, 2009/04, 2013/03
  • Hiroshima University, Japan, 2002/04, 2008/03

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Prosthodontics / Dental materials science and

Research Keywords

  • Prosthodontics

Affiliated Academic Societies

  • Japan Prosthodontic Society
  • Japan Society of Oral Implantology
  • International Association for Dental Research

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 3Term, Prosthetic Dentistry I
  2. 2025, Undergraduate Education, 4Term, Prosthetic Dentistry II
  3. 2025, Undergraduate Education, 3Term, Removable Prosthodontics I
  4. 2025, Undergraduate Education, 4Term, Removable Prosthodontics II
  5. 2025, Undergraduate Education, 2Term, Oral Implantology
  6. 2025, Undergraduate Education, 1Term, Basic Practice of Functional and Regenerative Oral Medicine I
  7. 2025, Undergraduate Education, 2Term, Basic Practice of Functional and Regenerative Oral Medicine II
  8. 2025, Undergraduate Education, 1Term, Practice of Prosthodontic Treatment for Edentulous Patients I
  9. 2025, Undergraduate Education, 2Term, Practice of Prosthodontic Treatment for Edentulous Patients II
  10. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  11. 2025, Undergraduate Education, 3Term, Practice of Prosthodontic Treatment for Partial Edentulous Patients I
  12. 2025, Undergraduate Education, 4Term, Practice of Prosthodontic Treatment for Partial Edentulous Patients II
  13. 2025, Undergraduate Education, 3Term, Basic Practice of Dental Prosthesis I
  14. 2025, Undergraduate Education, 4Term, Basic Practice of Dental Prosthesis II
  15. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  16. 2025, Undergraduate Education, 2Term, Advanced Course in Functional and Regenerative Oral Medicine
  17. 2025, Undergraduate Education, 2Term, General Dentistry III
  18. 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  19. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  20. 2025, Undergraduate Education, Academic Year, Clinical Practice (Denture Prosthodontics I)
  21. 2025, Undergraduate Education, Academic Year, Clinical Practice (Denture Prosthodontics II)
  22. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Advanced Prosthodontics
  23. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Advanced Prosthodontics
  24. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Advanced Prosthodontics
  25. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Advanced Prosthodontics

Research Activities

Academic Papers

  1. Comparison of plaque control record measurements obtained using intraoral scanner and direct visualization, Clinical and Experimental Dental Research, 10(1), e852, 20240201
    Link to Paper Search Results by DOI
  2. A Case Report of Oral Hygiene Evaluation Using Intraoral Schanner, 55(2), 138-142, 20231201
  3. Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring, Frontiers in pediatrics, 20230811
  4. LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4, JCI Insight, 8(7), 20230410
  5. Experimental tooth loss affects spatial learning function and blood-brain barrier of mice, Oral Dis., 20220916
  6. Association between dietary hardness score and activities of daily living among individuals aged 90 years, Clin Exp Dent Res., 2022
  7. Maximal voluntary tongue pressure is decreased in Japanese frail elderly persons, GERODONTOLOGY, 29(2), E1078-E1085, 2012
  8. Increased Crown-To-Implant Ratio May Not Be a Risk Factor for Dental Implant Failure under Appropriate Plaque Control, PLOS ONE, 8(5), 2013
  9. Influence of formalin fixation on the implant stability quotient and mechanical characteristics of bone, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 51(6), 550-554, 2013
  10. ★, Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice, BEHAVIOURAL BRAIN RESEARCH, 252, 318-325, 2013
  11. Development of Implant/Interconnected Porous Hydroxyapatite Complex as New Concept Graft Material, PLOS ONE, 7(11), 2012
  12. The Effect of Superstructures Connected to Implants with Different Surface Properties on the Surrounding Bone., Journal of Functional Biomaterials, 6(3), 623-633, 2015
  13. Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone-reduced rabbit model, JOURNAL OF ORAL SCIENCE, 58(2), 241-246, 201606
    Link to Paper Search Results by DOI
  14. Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse, GERODONTOLOGY, 33(3), 308-314, 201609
    Link to Paper Search Results by DOI
  15. Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice, BMC NEUROSCIENCE, 17, 20161205
    Link to Paper Search Results by DOI
  16. Preoperative evaluation of bone quality for dental implantation using an ultrasound axial transmission device in an ex vivo model, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 3(3), 81-86, 201706
    Link to Paper Search Results by DOI
  17. A stability evaluation of a novel titanium dental implant/interconnected porous hydroxyapatite complex under functional loading conditions, DENTAL MATERIALS JOURNAL, 36(5), 647-653, 201710
    Link to Paper Search Results by DOI
  18. Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection., Journal of Controlled Release, 286, 264-278, 20180928
  19. Osseointegration aspects of placed plant in bone reconstruction ith newly developed block-type interconnected porous calcium hydroxyapatite, JOURNAL OF APPLIED ORAL SCIENCE, 24(4), 325-331, 2016
  20. Influence of Implant Surface Topography on Primary Stability in a Standardized Osteoporosis Rabbit Model Study, JOURNAL OF FUNCTIONAL BIOMATERIALS, 6(1), 143-152, 201503
  21. APOE4-mediated amyloid beta-pathology depents on its neuronal receptor LRP1., The Journal of Clinical investigation, 129(3), 1272-1277, 20190301
  22. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways., Neuron, 106(5):727-742(5), 727-742, 20200603
  23. IL-6 Induced by Periodontal Inflammation Causes Neuroinflammation and Disrupts the Blood-Brain Barrier, Brain sciences, 10(10), E679, 20200927
  24. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease, Alzheimers Dement ., 16(10), 1372-1383
  25. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function, Neuron., 109(3), 438-447

Invited Lecture, Oral Presentation, Poster Presentation

  1. Establishment of bone density evaluation method using a novel bone cutting drill, DOI K, WAKAMATSU K, OKI Y, OUE H, KUBO T, KOBATAKE R, TSUGA K., 2023/10/29, Without Invitation, Japanese
  2. The effect of tooth loss on cerebrovascular in mouse model, Hiroshi Oue, Miyuki Yokoi, Eri Ishida, Hidenori Nishibata, Masaharu Shitozawa, Kazuhiro Tsuga, 2020/08/29, Without Invitation, Japanese
  3. The influence of tooth loss and diet on learning and memory by behavioral study, Yosuke Takeda, Katsunori Koretake, Hiroshi Oue, Shinsuke Okada, Yasumasa Akagawa, Kazuhiro Tsuga, Indonesian prosthodontic society and Japan prosthodontic society joint meeting, 2014/11/01, Without Invitation, English, Bali
  4. Effect of intermittent parathyroid hormone (PTH) administration on primary stability in osteoporosis rabbit model, Hiroshi Oue, Kazuya Doi, Yoshifumi Oki, Yusuke Makihara, Shiho Kajihara, Katsunori Koretake, Takayasu Kubo, Yasumasa Akagawa, Kazuhiro Tsuga, European Association for Osseointegration, 2014/09/25, Without Invitation, English, Rome
  5. Evaluation of implant stability in implant/interconnected pours hydroxyapatite complex, Shiho Kajihara, Kazuya Doi, Yoshifumi Oki, Takayasu Kubo, Hiroshi Oue, Yusuke Makihara, Kouji Morita, Kan Kato, Yasumasa Akagawa, European Association for Osseointegration, 2014/05/25, Without Invitation, English
  6. Evaluation of implant stability in nove implant/interconnected pours calcium hydroxyapatite complex, Yusuke Makihara, Kazuya Doi, Takayasu Kubo, Hiroshi Oue, Shiho Kajihara, Kouji Morita, Yasumasa Akagawa, Kazuhiro Tsuga, Scientific Meeting of the Asian Academy of Osseointegration, 2014/07/04, Without Invitation, English, Sapporo
  7. Effect of intermittent parathyroid hormone administration on primary stability in rabbit osteoporosis model, Kazuya Doi, Takayasu Kubo, Yusuke Makihara, Hiroshi Oue, Kan Kato, Yoshifumi Oki, Yasumasa Akagawa, Kazuhiro Tsuga, Scientific Meeting of the Asian Academy of Osseointegration, Without Invitation, English, Sapporo
  8. Tooth loss induces memory impairment and neuronal cell loss, Hiroshi Oue, The 91th General Session & Exhibition of the International Association for Dental Research, 2013/03/20, Without Invitation, English, Seattle, USA
  9. The deletion of LRP1 in vascular mural cells causes cognitive impairment depending on APOE isoforms, H. OUE, Y., YAMAZAKI, I.-E. MOSNEAG, T. AIKAWA, M.-L. HOLM, G. BU, T. KANEKIYO, Neuroscience 2018, 2018/11/07, Without Invitation, English, Society for Neuroscience, San Diego, CA, USA

Awards

  1. 2013/03/20, Arthur Frechette award, IADR, Tooth loss induces memory impairment and neuronal cell loss

External Funds

Acceptance Results of Competitive Funds

  1. MEXT Grant-in-Aid for Scientific Research (C), Elucidation of the mechanism of cognitive decline due to tooth loss using metabolomic analysis, 2024, 2026
  2. Grant-in-Aid for Scientific Research (C), 2020, 2022
  3. KAKENHI, 2014, 2015
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  4. KAKENHI, 2016, 2017