MASASHI KAWAMI

Last Updated :2024/07/22

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
Web Site
http://home.hiroshima-u.ac.jp/mtakano/index-e.html
E-mail
ma-kawamihiroshima-u.ac.jp
Other Contact Details
1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan, Japan
TEL : (+81) FAX : (+81)
Self-introduction
Biopharmaceutics and cell biology are my majors. I'm trying to establish preventive approach against drugs-induced lung injury as the adverse effects, and finally develop the specific method to suppress just the adverse drug reactions, but not the main pharmacological effect. I'm in charge of "Industrial Pharmaceutics" as a lecture using own career experiences in Pharmaceutical industry.

Basic Information

Academic Degrees

  • Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy

Research Keywords

  • alveolar epithelial cells, folate transporter, epithelial-mesenchymal transition, Thai plant extract

Affiliated Academic Societies

  • The Pharmaceutical Society of Japan
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  • The Japanese Society for the Study of Xenobiotics
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  • The Academy of Pharmaceutical Science and Technology, Japan
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  • American Association of Pharmaceutical Sciences, 2019/06

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  2. 2024, Undergraduate Education, First Semester, Practice of Drug Delivery System
  3. 2024, Undergraduate Education, 1Term, Pharmacokinetics
  4. 2024, Undergraduate Education, Intensive, Pharmacokinetics
  5. 2024, Undergraduate Education, 4Term, Industrial Pharmaceutics
  6. 2024, Undergraduate Education, First Semester, Practice of Pharmaceutics
  7. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  8. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  9. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  10. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  11. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  12. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  13. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Drug Delivery Sciences
  14. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Drug Delivery Sciences
  15. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Molecular Systems Pharmaceutics
  16. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Molecular Systems Pharmaceutics
  17. 2024, Graduate Education (Master's Program) , First Semester, Advanced Research on Molecular Systems Pharmaceutics
  18. 2024, Graduate Education (Master's Program) , Second Semester, Advanced Research on Molecular Systems Pharmaceutics
  19. 2024, Graduate Education (Master's Program) , Second Semester, Lecutre on Molecular Systems Pharmaceutics
  20. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Molecular Systems Pharmaceutics
  21. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Molecular Systems Pharmaceutics
  22. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Molecular Systems Pharmaceutics
  23. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Molecular Systems Pharmaceutics

Research Activities

Academic Papers

  1. Role of integrin alpha 2 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells, TOXICOLOGICAL RESEARCH, 38(4), 449-458, 202210
    Link to Paper Search Results by DOI
  2. A Liquid Chromatography-Mass Spectrometry Method to Study the Interaction between Membrane Proteins and Low-Molecular-Weight Compound Mixtures, MOLECULES, 27(15), 202208
    Link to Paper Search Results by DOI
  3. Role of Nrf2 in Methotrexate-Induced Epithelial-Mesenchymal Transition in Alveolar A549 Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 45(8), 1069-1076, 202208
  4. Preventive approach against drug-induced pulmonary fibrosis through the suppression of epithelial-mesenchymal transition, BIOCELL, 46(8), 1861-1865, 2022
    Link to Paper Search Results by DOI
  5. Effect of Corticosteroids on Peptide Transporter 2 Function and Induction of Innate Immune Response by Bacterial Peptides in Alveolar Epithelial Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 45(2), 213-219, 202202
  6. Characterization of miR-34a-Induced Epithelial-Mesenchymal Transition in Non-Small Lung Cancer Cells Focusing on p53, BIOMOLECULES, 11(12), 202112
    Link to Paper Search Results by DOI
  7. Differential mechanisms underlying methotrexate-induced cell death and epithelial-mesenchymal transition in A549 cells, TOXICOLOGICAL RESEARCH, 37(3), 293-300, 20210726
    Link to Paper Search Results by DOI
  8. Functional expression of equilibrative and concentrative nucleoside transporters in alveolar epithelial cells, PHARMAZIE, 76(9), 416-421, 202109
    Link to Paper Search Results by DOI
  9. ★, Evaluation on epithelial-mesenchymal state and microRNAs focusing on isolated alveolar epithelial cells from bleomycin injured rat lung, TOXICOLOGY, 461, 202109
    Link to Paper Search Results by DOI
  10. Direct N-1-Selective Alkylation of Hydantoins Using Potassium Bases, CHEMICAL & PHARMACEUTICAL BULLETIN, 69(4), 407-410, 202104
    Link to Paper Search Results by DOI
  11. ★, Investigation of Drug-induced Lung Injury for the Development of a Novel Therapeutic Approach, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 140(1), 15-22, 202001
  12. Effect of transforming growth factor-beta 1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 393(5), 889-896, 202005
    Link to Paper Search Results by DOI
  13. Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(3), 543-548, 20200507
    Link to Paper Search Results by DOI
  14. Transport of ribavirin in human myelogenous leukemia cell line K562, PHARMAZIE, 75(7), 329-334, 202007
    Link to Paper Search Results by DOI
  15. Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells, DRUG METABOLISM AND PHARMACOKINETICS, 35(6), 522-526, 202012
    Link to Paper Search Results by DOI
  16. miR-484: A Possible Indicator of Drug-Induced Pulmonary Fibrosis, JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 23, 486-495, 20201128
  17. Reduced folate carrier-mediated methotrexate transport in human distal lung epithelial NCl-H441 cells, JOURNAL OF PHARMACY AND PHARMACOLOGY, 71(2), 167-175, 201902
    Link to Paper Search Results by DOI
  18. ★, Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells, TOXICOLOGY, 424, 20190801
    Link to Paper Search Results by DOI
  19. Anticancer Drug-Induced Epithelial-Mesenchymal Transition via p53/miR-34a axis in A549/ABCA3 Cells, JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 22, 516-524, 20191007
  20. Investigation on inhibitory effect of folic acid on methotrexate-induced epithelial-mesenchymal transition focusing on dihydrofolate reductase, DRUG METABOLISM AND PHARMACOKINETICS, 34(6), 396-399, 201912
    Link to Paper Search Results by DOI
  21. Folic acid prevents methotrexate-induced epithelial-mesenchymal transition via suppression of secreted factors from the human alveolar epithelial cell line A549, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 497(1), 457-463, 20180226
    Link to Paper Search Results by DOI
  22. Transport of AOPP-Albumin into Human Alveolar Epithelial A549 Cells, JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 21, 247-255, 2018
    Link to Paper Search Results by DOI
  23. P-gp modulating effect of Azadirachta indica extract in multidrug-resistant cancer cell lines, PHARMAZIE, 73(2), 104-109, 201802
    Link to Paper Search Results by DOI
  24. Effect of Curcuma comosa extracts on the functions of peptide transporter and P-glycoprotein in intestinal epithelial cells, PHARMAZIE, 72(2), 123-127, 201702
    Link to Paper Search Results by DOI
  25. Effect of COA-Cl on transforming growth factor-beta 1-induced epithelialemesenchymal transition in RLE/Abca3 cells, DRUG METABOLISM AND PHARMACOKINETICS, 32(4), 224-227, 201708
    Link to Paper Search Results by DOI
  26. Nicotine transport in lung and non-lung epithelial cells, LIFE SCIENCES, 188, 76-82, 20171101
    Link to Paper Search Results by DOI
  27. Role of miR-34a in TGF-beta 1-and Drug-Induced Epithelial-Mesenchymal Transition in Alveolar Type II Epithelial Cells, JOURNAL OF PHARMACEUTICAL SCIENCES, 106(9), 2868-2872, 201709
    Link to Paper Search Results by DOI
  28. Methotrexate-Induced Epithelial-Mesenchymal Transition in the Alveolar Epithelial Cell Line A549, LUNG, 194(6), 923-930, 201612
    Link to Paper Search Results by DOI
  29. Analysis of TGF-beta 1-and drug-induced epithelial-mesenchymal transition in cultured alveolar epithelial cell line RLE/Abca3, DRUG METABOLISM AND PHARMACOKINETICS, 30(1), 111-118, 201502
    Link to Paper Search Results by DOI
  30. Receptor-mediated endocytosis of macromolecules and strategy to enhance their transport in alveolar epithelial cells, EXPERT OPINION ON DRUG DELIVERY, 12(5), 813-825, 201505
    Link to Paper Search Results by DOI
  31. Methotrexate influx via folate transporters into alveolar epithelial cell line A549, DRUG METABOLISM AND PHARMACOKINETICS, 30(4), 276-281, 201508
    Link to Paper Search Results by DOI
  32. Modulation of P-glycoprotein function and multidrug resistance in cancer cells by Thai plant extracts, PHARMAZIE, 69(11), 823-828, 201411
    Link to Paper Search Results by DOI
  33. Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells, DRUG METABOLISM AND PHARMACOKINETICS, 25(2), 155-162, 2010
  34. Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2, DRUG MATABOLISM AND PHARMACOKINETICS, 25(4), 418-427, 2009
  35. Transport across the cell membrane and its regulation by vesicular transport, MEMBRANE, 40(1), 21-28, 2015

Invited Lecture, Oral Presentation, Poster Presentation

  1. Mechanism of the inhibitory effect of inhaled corticosteroids on peptide transporter 2 function in human alveolar epithelial cells, Nanako Kameda, Shiori Kuriyama, Masashi Kawami, Ryoko Yumoto, Mikihisa Takano, 2021/11/17, Without Invitation, Japanese
  2. Effect of 2-deoxy-D-glucose on transforming growth factor-b1-induced epithelialmesenchymal transition in alveolar epithelium, Masashi Kawami, Kohei Kawabata, Ryoko Yumoto, Hiroyuki Nishi, Akira Tokumura, Mikihisa Takano, 2021/11/17, Without Invitation, Japanese
  3. In vitro and in vivo studies on involvement of miR-222 in epithelial-mesenchymal transition in alveolar epithelial cells, Yuri Kadekaru, Takashi Konaka, Shinnosule Takenaka, Mizuki Akai, Masashi Kawami, Ryoko Yumoto, Mikihisa Takano, 2021/11/17, Without Invitation, Japanese
  4. ROLE OF MICRORNAS IN DRUG-INDUCED EPITHELIAL-MESENCHYMAL TRANSITION IN HUMAN LUNG-DERIVED ALVEOLAR TYPE II EPITHELIAL CELL MODEL A549/ABCA3, Ryoko Yumoto, Ayano Yamamoto, Takashi Konaka, Shinnosuke Takenaka, Masashi Kawami, Mikihisa Takano, ISSX2019: The 12th International ISSX Meeting, 2019/07/28, Without Invitation, English, The Oregon Convention Center in Portland, Oregon, USA
  5. In vitro study on secreted factors associated with drug-induced epithelial-mesenchymal transition in A549 cells, Masashi Kawami, Yohei Yamagami, Risako Harada, Takamichi Ojima, Ryoko Yumoto, Mikihisa Takano, The 1st Workshop of The Research Center for Drug Development and Biomarker Discovery, 2019/03/02, Without Invitation, English
  6. Role of transporters related to metabolic changes during epithelial-mesenchymal transition in human alveolar epithelial cell line A549, Mohi Uddin, Ryoko Yumoto, Masashi Kawami, Mikihisa Takano, 2018 International Meeting on 22nd MDO and 33rd JSSX, 2018/10/04, Without Invitation, English, Ishikawa Ongakudo Hall
  7. Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in cultured human alveolar epithelial A549 cells, Yohei Yamagami, Ryoko Yumoto, Masashi Kawami, Mikihisa Takano, 2018 International Meeting on 22nd MDO and 33rd JSSX, 2018/10/04, Without Invitation, English, Ishikawa Ongakudo Hall
  8. Study on association of drug-induced cell cycle arrest with epithelial-mesenchymal transition in A549 cells, Masashi Kawami, Risako Harada, Takamichi Ojima, Ryoko Yumoto, Mikihisa Takano, 2018 International Meeting on 22nd MDO and 33rd JSSX, 2018/10/02, Without Invitation, English, Ishikawa Ongakudo Hall
  9. Role of miR-34a and p53 pathway in drug-induced epithelial-mesenchymal transition in alveolar epithelial cells, Ayano Yamamoto, Masashi Kawami, Ryoko Yumoto, Mikihisa Takano, 2018 International Meeting on 22nd MDO and 33rd JSSX, 2018/10/02, Without Invitation, English, Ishikawa Ongakudo Hall

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2022, 2025
  2. KAKENHI, 2022, 2025
  3. KAKENHI, 2021, 2024
  4. 2020, 2021
  5. 2019
  6. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2021
  7. KAKENHI, 2016, 2018

Social Activities

History as Peer Reviews of Academic Papers

  1. 2022, Biological and Pharmaceutical Bulletin, Others, 3
  2. 2022, Biomolecules, Others, 3
  3. 2022, International Journal of Molecular Sciences, Others, 2
  4. 2022, Drug Design, Development, and Therapy, Others, 2
  5. 2022, Toxicology Research, Others, 2
  6. 2022, Journal of Clinical Medicine, Others, 2
  7. 2022, BMC Ophthalmology, Others, 3
  8. 2022, Medical Oncology, Others, 2
  9. 2022, World Journal of Surgical Oncology, Others, 1
  10. 2022, Veterinary Sciences, Others, 1
  11. 2022, Scientific Report, Others, 7
  12. 2022, Bioengineered, Others, 7
  13. 2022, Antioxidants, Others, 2
  14. 2021, Applied Sciences, Others, 2
  15. 2021, Medical Oncology, Others, 1
  16. 2021, BMC Pulmonary Medicine, Others, 1
  17. 2021, BMC Ophthalmology, Others, 1
  18. 2021, Toxics, Others, 1
  19. 2021, Scientific Report, Others, 1
  20. 2021, Bioengineered, Others, 5
  21. 2021, Current Medical Science, Others, 1
  22. 2021, World Journal of Surgical Oncology, Others, 2
  23. 2021, BIOCELL, Others, 4
  24. 2021, Biological and Pharmaceutical Bulletin, Others, 4
  25. 2020, Biological and Pharmaceutical Bulletin, Others, 4
  26. 2020, BIOCELL, Others, 1
  27. 2020, Journal of Cellular and Molecular Medicine, Others, 2
  28. 2019, Biological and Pharmaceutical Bulletin, Others, 2
  29. 2018, Biological and Pharmaceutical Bulletin, Others, 1