Tetsuo Hirano

Last Updated :2023/09/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
thiranohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D. Doctor of Medical Science, The University of Tokyo
  • Master of Science, Kyoto University

Research Fields

  • Biology;Biological Science;Molecular biology

Research Keywords

  • tumorigenesis
  • double minute chromosomes
  • gene amplification
  • leukemia
  • mt DNA
  • HL-60

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  2. 2023, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  3. 2023, Undergraduate Education, Intensive, Lecture and Laboratory courseIn Marine Biology
  4. 2023, Undergraduate Education, 2Term, Molecular Biology of Cancer I
  5. 2023, Undergraduate Education, 2Term, Molecular Biology of Cancer II

Research Activities

Academic Papers

  1. ★, Genes encoded within 8q24 on the amplicon of a large extrachromosomal element are selectively repressed during the terminal differentiation of HL-60 cells, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 640(1-2), 97-106, 20080402
  2. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
  3. Loss of Amplified c-myc Genes in the Spontaneously Differentiated HL-60 Cells, Cancer Research, 54, 3561-3567, 19940401
  4. Involvement of Mac-l-Mediated Adherence and Sphingosine-l-Phosphate in Survival of Phorbol Ester-treated U937 cells, Biochemical and Biophysical Research Communications, 244, 745, 19980401
  5. Survival by Mac-l-Mediated abherence and Anoikis in Phorbal Ester-treated HL-60 cells, The Journal of Biological Chemistry, 273(25), 15345, 19980401
  6. Co-localization of mitochondrial and double minute DNA in the nuclei of HL-60 cells but not normal cells, MUTATION RESEARCH Fundamental and Molecular Mechanisms of Metagenesis, 425(2), 195-204, 19990401
  7. Apoptosis inducing factors released from mitochondria(mini-review, Japanese), 37(5), 324-5, 19990401
  8. A novel transcriptional regulatory factor that binds to the polyoma virus enhancer in a developmental stage-specific manner, Biochimie, 72(5), 327-36, 19900401
  9. Granulocytic differentiation of HL-60 cells, both spontaneous and drug-induced, might require loss of extrachromosomal DNA encoding a gene(s) not c-MYC, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 288(3), 586-591, 20011102
  10. Evolution of large extrachromosomal elements in HL-60 cells during culture and the associated phenotype alterations, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 288(3), 592-596, 20011102
  11. Loss of irreversibility of granulocytic differentiation induced by dimethyl sulfoxide in HL-60 sublines with a homogeneously staining region, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 288(5), 1182-1187, 20011116
  12. Theoretical and experimental dissection of competitive PCR for accurate quantification of DNA, ANALYTICAL BIOCHEMISTRY, 303(1), 57-65, 20020401
  13. ★, Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression, MOLECULAR CANCER, 14, 20150419
  14. An Active C-Terminally Truncated Form of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase-N (CaMKP-N/PPM1E), BIOMED RESEARCH INTERNATIONAL, 2013
  15. ★, The role of the CCDC26 long noncoding RNA as a tumor suppressor., RNA & DISEASE, 3, e1022, 2016
  16. Ca2þ/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association, Biochemical and Biophysical Research Communications, 477, 820-825, 2016
  17. ★, Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1868(3), 202103

Publications such as books

  1. 2011/11, Role of CCDC26, A Novel Non-Coding RNA, In Human Acute Myeloid Leukemia: Advances in Genetics Research. Volume 5, K. V. Urbano (Editor), pp.131-140, 2011, 11, Scholarly Book, Cocompilation, 9781621007050
  2. 2009/07, Role of Extrachromosomal Elements in HL-60 Human Leukemia Cells, in The Human Genome: Features, Variations and Genetic Disorders, A. Matsumoto and M. Nakano (Editor), pp.91-100, NOVA Science Publishers= Inc., 2009, 07, Scholarly Book, Joint work, 9781607416951

Invited Lecture, Oral Presentation, Poster Presentation

  1. Non-coding RNA CCDC26 controls growth of myeloid leukemia cells through regulation of c-Kit expression, Tetsuo Hirano, Ryouko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida, Takeshi Yamazaki, The molecular biology society of Japan, 2014/11/27, Without Invitation, Japanese, published
  2. Identification and expression analysis of CCDC26 mouse homologs correlates with acute myeloid leukemia., Ryouko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida, Takeshi Yamazaki, The Molecular Biology Society of Japan, 2014/11/27, Without Invitation, Japanese, published
  3. The role of noncoding RNA CCDC26 in erythroblast-like differentiation of myeloid leukemia cell (2P-0684), Tomomi Tsuruda, Yuka Tanaka, Atsuhiko Ishida, Takeshi Yamazaki, Tetsuo Hirano, ConBio2017, 2017/12/07, Without Invitation, English
  4. Control mechanism of localization of intracellular Interleukin-1a in fibroblast (2P-0948), Erika Hayayumi, Kaho Tanouchi, Arika Hayashi, Takeshi Yamazaki, Atsuhiko Ishida, Tetsuo Hirano, ConBio2017, 2017/12/07, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2022, 2024

Social Activities

History as Peer Reviews of Academic Papers

  1. 2019, Molecular Medicine Reports, Editor, 1
  2. 2019, Oncology Reports, Editor, 1
  3. 2019, International Journal of Oncology, Editor, 1
  4. 2019, International Journal of Oncology, Editor, 1
  5. 2019, Oncology Reports, Editor, 1
  6. 2020, Oncology Reports, Editor
  7. 2020, Molecular Medicine Reports, Editor, 1
  8. 2020, International Journal of Hematology, Editor, 1
  9. 2020, International Journal of Molecular Medicine, Editor, 1
  10. 2020, International Journal of Molecular Medicine, Editor, 1
  11. 2020, Oncology Reports, Editor, 1
  12. 2020, Oncology Reports, Editor, 1
  13. 2020, Oncology Letters, Editor, 1
  14. 2020, Oncology Letters, Editor, 1
  15. 2020, International Journal of Oncology, Editor, 1
  16. 2021, Molecular Medicine Reports, Editor, 1
  17. 2021, Biochemistry and Biophysics Reports, Editor, 3
  18. 2021, Experimental and Therapeutic Medicine, Editor, 1
  19. 2021, The Journal of Biochemistry, Editor, 3
  20. 2022, Experimental and Therapeutic Medicine, Editor, 1
  21. 2015, International Journal of Molecular Medicine, Others, Reviewer, 1
  22. 2016, Biomedicine & Pharmacotherapy, Others, Reviewer, 1
  23. 2013, Mutation research, Others
  24. 2016, Experimental and Therapeutic Medicine, Others
  25. 2016, Biomedicine & Pharmacotherapy, Others
  26. 2016, Experimental and Therapeutic Medicine, Others
  27. 2016, International Journal of Oncology, Others
  28. 2017, Oncotarget, Others
  29. 2017, Oncology Reports, Others
  30. 2016, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Others
  31. 2017, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Others
  32. 2017, Cancer Science
  33. 2017, Experimental and Therapeutic Medicine, Others
  34. 2017, Cancer Science, Others
  35. 2017, Oncotarget, Others
  36. 2017, Experimental and Therapeutic Medicine, Others
  37. 2017, Current Proteomics, Others
  38. 2018, Oncology Letters, Others
  39. 2018, OncoTargets and Therapy, Others
  40. 2018, International Journal of Molecular Medicine, Others
  41. 2018, OncoTargets and Therapy
  42. 2018, Molecular Medicine Reports, Others
  43. 2018, Disease Markers, Others
  44. 2018, Experimental and Therapeutic Medicine, Others
  45. 2018, Experimental and Therapeutic Medicine, Others
  46. 2018, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Others