MASANORI SUGIYAMA

Last Updated :2025/12/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor (Collaborative Research Lab)
Web Site
http://en.hiroshima-u.jp/bhs/research/lab/other/Probiotic_Science_for_Preventive_Medicine
E-mail
sugihiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5280 FAX : (+81)82-257-5284
Self-introduction
I (Professor Sugiyama) have studied on the self-resistance mechanisms in antibiotic-producing actinomyces during 40 years. My boss, who had employed me as a assistant professor, has always encouraged me at the following phrase: "If you will continue the study for 10 years, you will be an expert at the microbiology field. Furthermore, if you will continue the study as your lifework, you will become an authority at the scientific field.

Basic Information

Major Professional Backgrounds

  • 1987/05/01, Institute Pasteur Paris, Microbiolgy Unit, Researcher
  • 1992/04/01, Hiroshima University, Faculty of Medicine, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Engineering, Japan, 1974/04, 1976/03
  • Hiroshima University, Faculty of Engineering, Japan, 1971/04, 1974/03

Academic Degrees

  • Doctor of Engineering, Hiroshima University
  • Master of Engineering, Hiroshima University

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Natural medicines

Research Keywords

  • X-ray crystallography
  • three dimensional analysis of protein by X-ray
  • actinomycetes
  • plant-derived lactic acid bacteria
  • molecular microbiology
  • gene regulation sciences
  • antibiotics
  • probiotics
  • secondary metabolite

Affiliated Academic Societies

  • The Society for Biotechnology,Japan
  • The Phamaceutical Society of Japan
  • Japanese Society for Bachteriology
  • The Society for Actinomycetes Japan
  • Japan Society for Lactic Acid Bacteria
  • ASBMB　(The American Society for Biochemistry and Molecular Biology)
  • Japan Bioindustiry Association

Educational Activity

Course in Charge

  1. 2025, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  2. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  3. 2025, Graduate Education (Master's Program) , 4Term, Lecture on Probiotic Science for Preventive Medicine
  4. 2025, Graduate Education (Master's Program) , First Semester, Seminar on Probiotic Science for Preventive Medicine
  5. 2025, Graduate Education (Master's Program) , Second Semester, Seminar on Probiotic Science for Preventive Medicine
  6. 2025, Graduate Education (Master's Program) , First Semester, Research on Probiotic Science for Preventive Medicine
  7. 2025, Graduate Education (Master's Program) , Second Semester, Research on Probiotic Science for Preventive Medicine
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Probiotic Science for Preventive Medicine
  11. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Probiotic Science for Preventive Medicine

Award of Education

  1. 2014/11/03

Research Activities

Academic Papers

  1. Integrator Complex Subunit 6 Regulates Biological Nature of Hepatocellular Carcinoma by Modulating Epithelial-Mesenchymal Transition, CURRENT ISSUES IN MOLECULAR BIOLOGY, 47(9), 20250909
    Link to Paper Search Results by DOI
  2. Strategic approach of disease-prevention based upon variability of intestinal microbiota and biological impact induced by ingested sour-bread baked with plant-derived lactic acid bacteria in mice, 106, 31-40, 2024
  3. Non-pathogenic Heyndrickxia coagulans (Bacillus coagulans) 29-2E inhibits the virulence of pathogenic Salmonella Typhimurium by quorum-sensing regulation, J Biosci Bioeng, 137, 445-452, 202403
    Link to Paper Search Results by DOI
  4. Stevia Leaf Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T Displays Anticancer Activity to Pancreatic Cancer PANC-1 Cell Line, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26(9), 20250428
    Link to Paper Search Results by DOI
  5. Atractylodes Japonica Rhizome Extract Fermented with a Plant-Derived Lacticaseibacillus paracasei (Lactobacillus paracasei) IJH-SONE68 Improves the Wheat Gliadin-Induced Food Allergic Reaction in Mice, NUTRIENTS, 17(7), 20250326
    Link to Paper Search Results by DOI
  6. Eriobotrya japonica Fermentation with Plant-Derived Lactiplantibacillus plantarum MSC-5T Ameliorates Antioxidant Activity in HEK293 Cells,, 10(4), 202404
  7. Role of Phenolic Acid Metabolism in Enhancing Bioactivity of Mentha Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T, 16(3), 1052-1064, 202406
  8. Characterization of the Gamma-Aminobutyric Acid (GABA) Biosynthetic Gene Cluster in High GABA-Producing Enterococcus avium G-15, FERMENTATION-BASEL, 10(8), 202408
    Link to Paper Search Results by DOI
  9. Fermented stevia improves alcohol poisoning symptoms associated with changes in mouse gut microbiota, Nutrients, 15(3708), 20230824
  10. Role of phenolic acid metabolism in enhancing bioactivity of mentha extract fermented with plant-derived Lactobacillus plantarum SN13T, Probiotics Antimicrob Proteins, 16(3), 1052-1064, 202306
  11. Awareness Survey on Genetic Testing among Pharmacists in Hiroshima City, JAPANESE JOURNAL OF SOCIAL PHARMACY, Vol 41(No,1), 56-68, 2022
  12. A novel prokaryotic phospholipase A(2) - Characterization, gene cloning, and solution structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20051-20058, 20020531
    Link to Paper Search Results by DOI
  13. Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1778(1), 33-41, 200801
    Link to Paper Search Results by DOI
  14. Susceptibility of protein synthesis to streptomycin in streptomycin-producing ., FEBS Letters, 250-252, 19800401
  15. Assessment of competitive action of streptomycin 6-kinase and streptomycin 6-phosphatase in the in vitro protein synthesis of a streptomycin-producing microorganism., FEBS Letters, 331-333, 19820401
  16. Molecular cloning and expression in of a streptomycin 6-phosphotransferase gene from a streptomycin-producing microorganism., FEBS Letters, 385-389, 19850401
  17. Susceptibility of protein synthesis to neomycin in neomycin-producing ., Journal of General Microbiology(U. K. )=, 477-478, 19800401
  18. Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin producing microorganism., Journal of General Microbiology(U. K. )=, 1683-1687, 19830401
  19. Mechanism of self-protection in a puromycin-producing microorganism., Journal of General Microbiology(U. K. )=, 1999-2005, 19850401
  20. The nucleotide sequence of a streptomycin 6-phosphotransferase gene from a streptomycin producer., Journal of General Microbiology(U. K. )=, 1289-1296, 19870401
  21. Use of the tyrosinase gene from to probe promoter sequences for ., Plasmid(U. S. A), 237-241, 19900401
  22. Plasmid involvement in the degradation of polycyclic aromatic hydrocarbons by a Beijerinckia species., Biochemical and Biophysical Research Communications, 939-945, 19830401
  23. Biosynthetic correlation between streptomycin and mucopeptide in utilization of D-glucosamine as a common precursor., Journal of Fermentation Technology, 91-96, 19810401
  24. Binding of streptomycin to the teichoic acid of streptomycin-producing ., Journal of Fermentation Technology, 13-17, 19820401
  25. Ribosomal resistance to streptomycin in strains regenerated from protoplasts of a streptomycin-susceptible mutant derived from a streptomycin producer., Journal of Fermentation Technology, 347-351, 19830401
  26. Streptothricin production by a new isolate of from Thailand soil., Journal of Fermentation Technology, 19-28, 19840401
  27. In vivo cloning of arylsulfatase-tyramine oxidase genes in rec strains of ., Agricultural and Biological Chemistry, 1807-1815, 19830401
  28. Intracellular accumulation of trehalose during streptomycin formation by ., Agricultural and Biological Chemistry, 285-290, 19840401
  29. Correlation between intracellular accumulation of peptideglycan precursors and streptomycin formation., Agricultural and Biological Chemistry, 291-297, 19840401
  30. Molecular cloning and expression of a sarcosine oxidase gene in ., Bioscience= Biotechnology and Biochemistry, 432-436, 19920401
  31. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain., Journal of Antibiotics, 1183-1188, 19810401
  32. Effect of arginine of gramicidin S biosynthesis by< Bacillus>., Journal of Antibiotics, 615-621, 19820401
  33. Isolation and properties of a puromycin acetyltransferase from puromycin-producing ., Journal of Antibiotics, 1761-1766, 19850401
  34. Acetylation of blasticidin S by its producing actinomycetes., Journal of Antibiotics, 827-832, 19860401
  35. Isolation and properties of a blasticidin S acetylating enzyme from a producer organism., Journal of Antibiotics, 135-137, 19890401
  36. The primary structure of an acidic ribosomal protein from ., Biochimica et Biophysica Acta, 164-172, 19820401
  37. Fate of streptomycin in mycelium of the producer organism., Biotechnology Letters(U. K. ), 239-244, 19810401
  38. Roles of streptomycin 6-kinase and ribosomal affinity to streptomycin in self-protection of streptomycin producer., Biotechnology Letters(U. K. ), 357-362, 19810401
  39. Mechanism of resistance to streptothricin of a producing microorganism., Biotechnology Letters(U. K. ), 441-446, 19830401
  40. Protoplast formation and the regeneration of ATCC9999 and its mutants., Biotechnology Letters(U. K. ), 709-714, 19830401
  41. Overproduction of human insulin-like growth factor-(]G0002[) in ., Biotechnology Letters(U. K. ), 839-844, 19890401
  42. Kinetic studies of streptomycin uptake implicated in selfresistance in a streptomycin producer., Biotechnology Letters(U. K. ), 1-6, 19900401
  43. Silence of streptomycin 6-phosphotransferase gene derived by incubation at a high temperature in ., Biotechnology Letters(U. K. ), 537-542, 19910401
  44. Efficient purification and analysis for stability of human secretin precursor-like peptide produced in ., Biotechnology Letters(U. K. ), 603-608, 19910401
  45. Expression of an artificial gene coding for a human secretin precursor-like peptide in ., Journal of Fermentation and Bioengineering, 179-182, 19910401
  46. Two genes for streptomycin phosphotransferase in ., 353-358, 19880401
  47. Isolation and properties of the axopodial cytoskelton of a heliozoan, ., European Journal of Ptotistology, 214-219, 19920401
  48. Electrophoretic migration of the heliozoan, ., Cytobios(U. K. ), 107-114, 19840401
  49. Streptomycin biosynthesis and self-resistance mechanism in streptomycin-producing ., Actinomycetol., 15-22, 19900401
  50. Resistant mechanism to blasticidin S in ., Korean Biochemical Journal, 327-330, 19910401
  51. Mechanism of self-protection and genes coding for antibiotic biosynthesis , particularly, in microorganisms which produce antibiotic inhibitors of protein synthesis., J. Kor. Agric. Chem. Soc., 371-375, 19880401
  52. Ultrastructure and calcium-dependent contraction of the myonemal network in a heterotrich ciliate, ., European Journal of Ptotistology, 279-287, 19920401
  53. Structure and function of the cytoskeleton in Heliozoa : 2. Measurement of the force of rapid axopodial contraction in Echinosphaerium., European Journal of Ptotistology, 430-433, 19920401
  54. Molecular cloning and high expression of the creatinase gene in ., Journal of Fermentation and Bioengineering, 77-82, 19930401
  55. Susceptibility of methicillin-resistant clinical isolates to various antimicrobial agents. III. Novel. inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima Journal of Medical Sciences, 101-107, 19930401
  56. Cloning, sequencing, and overexpression in of a sarcosine oxidase-encoding gene linked to the creatinase gene., Journal of Fermentation and Bioengineering, 231-234, 19940401
  57. Expression of c-kit ligand in human keratinocytes., Arch Dermatol Res., 273-277, 19940401
  58. Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus, FEMS Microbiology Letters, 121, 81-86, 19940401
  59. Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin, Gene, 11-16, 19940401
  60. Uracil-targeted inhibition of poly(A)-poly(U) hybridization by a zinc(II)-cyclen complex., Chem. Commun., 1747-1748, 19940401
  61. Overproduction of the bleomycin-binding proteins from bleomycin-producing Streptomyces verticillus and a methicillin-resistant Staphylococcus aureus in Escherichia coli andtheir immunological characterisation, FEBS Lett, 80-84, 19950401
  62. Novel assay system favorable for the study of cell-to-cell transmission of HIV-1 and its application to the evaluation of anti-HIV drugs., Biological and Pharmaceutical Bulletin, 18, 920-922, 19950401
  63. Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity., Biological and Pharmaceutical Bulletin, 18, 996-1000, 19950401
  64. Dimeric macrocyclic polyamines with potent inhibitory activity against human immunodeficiency virus., Antiviral Chemistry and Chemotherapy, 6, 337-344, 19950401
  65. The photoreceptor pigment of the unicellular organism Blepharisma generates hydroxyl radicals., Journal of Photochemistry and Photobiology, B:Biology34, 29-33, 19960401
  66. Expression of multiple forms of fetal liver kinase-2 (flk-2/flk-3) ligand in cultured human keratinocytes., Arch Dermatol Res., 289, 177-179, 19970401
  67. Development of a useful vector system that enables visual detection of inhibitor of nucleic acid synthesis, J. Ferment. Bioeng., 84, 155-157, 19970401
  68. Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus, FEMS Microbiol. Lett., 155(67), 71, 19970401
  69. Oxidative and random cleavage of DNA by the novel iron(II)complex capable of yielding an iron(III)hydroperoxide intermediate., Chem. Lett., 39-40, 19980401
  70. Protection of mammalian cells from the toxicity of bleomycin by expression of a bleomycin-binding protein gene from Streptomyces verticillus, J. Biochem., 124, 835-841, 19980401
  71. Characterization of the bleomycin resistance determinant ercoded on the Tn5, FEBS Lett, 442, 34-38, 19990401
  72. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5., Acta Cryst. Sec., D55, 1095-1097, 19990401
  73. Mutation of the N-terminal Proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin, FEBS Lett, 450, 227-230, 19990401
  74. Synthesis, Spectroscopic, Redox Properties, and DNA cleavage Activity of Low-spin Iron((]G0003[))complexes of Bleomycin Analogues., Inorgania Chimica Acta, 294, 56-61, 19990401
  75. Growth of human pancreatic cancer cells, induced by human pancreatic phospholipase A2, is mediated via its specific receptor but not via its catalytic property, INTERNATIONAL JOURNAL OF ONCOLOGY, 9, 1219-1225, 19961201
  76. Human pancreatic phospholipase A2 stimulates the growth of human pancreatic cancer cell line, FEBS Letters, 373, 85-87, 19951001
  77. Gene technology to overproduce the enzymes useful as diagnostic reagents, 43(8), 765-771, 19950801
  78. Ultrastracture and rapid axopodial contraction of a heliozoa, Raphidiophrys contractilis sp. nov., Journal of Eukaryotic Microbiology, 42(3), 283-288, 19950501
  79. Susceptibility of Methicillin-resistant Staphylococcus aureus clinical isolates to various antimicrobial agents. III. Novel, inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima J. Med. Sci., 42, 101-107, 19930101
  80. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1., J. Basic Microbiol., 42, 190-200, 20020401
  81. Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content, Actinomycetologica, 16(2), 17-20, 20020401
  82. Atomic resolution structure of the prokaryotic phospholopase A2: Molecular motion and implication for catalytic mechanism., PROTEINS: Structure= Function= and Genetics, 51(3), 453-469, 20030501
  83. Molecular and structural biology of bleomycin and its resistance determinants., J. Bioscience and Bioengineering, 93, 105-116, 20020401
  84. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, J. Antibiotics, 56, 762-767, 20030401
  85. Physical stress by magnetic force accelerates differentiation of human osteoblasts, Biochem. Biophys. Res. Common, 32-38, 20030401
  86. Molecular cloning and expression of uricase gene from Arthrobactor globiformis in Escherichia coli and characterization of the gene product, J. Biosc. Bioeng.=, 153-158, 20040401
  87. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castanepglobisporus, Protein Expr Purif, 34, 202-207, 20040401
  88. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, Bioscience, Biotechnology, and Biochemistry, 71(11), 2852-2855, 20071101
  89. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat., In Vitro Cell Dev Biol Anim, 39(1-2), 89-97, 20030101
  90. A novel assay method for an amino acid racemase reaction based on circular dichroism, Biochem. J., 389, 491-496, 20050701
  91. Self-protection mechanisms of antibiotic-producing microorganisms, Nippon rinsyo, 65, 669-673, 20070228
  92. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5, Acta Crystallogr. Sect. D, 55, 1095-1097, 19990501
  93. A mammalian vector carrying the bleomycin N-acetyltransferase gene from Streptomyces verticillus as a selective marker, J. Antibiot., 52, 895-899, 19990401
  94. Molecular and structural biology of bleomycin and its resistance determinants, J. Biosci. Bioeng., 93, 105-116, 20020401
  95. Effects of methionine and Cu2+ on the expression of tyrosinase activity in Streptomyces castaneoglobisporus., J. Biochem., 120(6), 1141-1145, 19961201
  96. Molecular cloning and characterization of a gene encoding a novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis., J. Biosci. Bioeng., 101(1), 63-69, 20061101
  97. Establishment of an in vitro Peyer's patch cell culture system correlative to in vivo study using intestine and screening of lactic acid bacteria enhancing intestinal immunity., Biol. Pharm. Bull., 33(2), 289-293, 20100201
  98. ★, Crystal structure of SCCA1 and insight about the interaction with JNK1., Biochem. Biophys. Res. Commun., 380(1), 143-147, 20090201
  99. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im., Biochem. Biophys. Res. Commun., 378(3), 574-548, 20090101
  100. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS: Structure= Function= and Genetics, 79(10), 2999-3005, 20110901
  101. Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line., FEBS Letters, 407, 343-346, 19970501
  102. The 1.5 angstrom crystal structure of a bleomycin resistance determinant from bleomycin-producing Streptomyces verticillus, JOURNAL OF MOLECULAR BIOLOGY, 295(4), 915-925, 20000128
    Link to Paper Search Results by DOI
  103. A novel approach to gene therapy of albino hair in histoculture with a retroviral Streptomyces tyrosinase gene, PIGMENT CELL RESEARCH, 13(5), 345-351, 200010
    Link to Paper Search Results by DOI
  104. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 90(5), 574-576, 200011
    Link to Paper Search Results by DOI
  105. Crystallization and preliminary X-ray diffraction studies of Streptomyces phospholipase A(2) in a calcium-binding form, JOURNAL OF INORGANIC BIOCHEMISTRY, 82(1-4), 221-223, 200011
    Link to Paper Search Results by DOI
  106. Use of bleomycin- and heat shock-induced calreticulin promoter for construction of a mammalian expression vector, JOURNAL OF BIOCHEMISTRY, 129(5), 671-674, 200105
    Link to Paper Search Results by DOI
  107. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 9992-9999, 20010330
    Link to Paper Search Results by DOI
  108. The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(3), 2311-2320, 20020118
    Link to Paper Search Results by DOI
  109. Molecular and structural biology of bleomycin and its resistance determinants, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93(2), 105-116, 200202
    Link to Paper Search Results by DOI
  110. The crystal structure of prokaryotic phospholipase A(2), JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20059-20069, 20020531
    Link to Paper Search Results by DOI
  111. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1, JOURNAL OF BASIC MICROBIOLOGY, 42(3), 190-200, 2002
    Link to Paper Search Results by DOI
  112. Physical stress by magnetic force accelerates differentiation of human osteoblasts, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 311(1), 32-38, 20031107
    Link to Paper Search Results by DOI
  113. Atomic resolution structure of prokaryotic phospholipase A(2): Analysis of internal motion and implication for a catalytic mechanism, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 51(3), 453-469, 20030515
    Link to Paper Search Results by DOI
  114. Molecular mechanism for the enhancement of arbekacin resistance in a methicillin-resistant Staphylococcus aureus, FEBS LETTERS, 546(2-3), 401-406, 20030710
    Link to Paper Search Results by DOI
  115. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 89-97, 2003
    Link to Paper Search Results by DOI
  116. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, JOURNAL OF ANTIBIOTICS, 56(9), 762-767, 200309
    Link to Paper Search Results by DOI
  117. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castaneoglobisporus, PROTEIN EXPRESSION AND PURIFICATION, 34(2), 202-207, 200404
    Link to Paper Search Results by DOI
  118. Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46153-46161, 20041029
    Link to Paper Search Results by DOI
  119. Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae - Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46143-46152, 20041029
    Link to Paper Search Results by DOI
  120. Molecular cloning and expression of uricase gene from Arthrobacter globiformis in Escherichia coli and characterization of the gene product, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 98(3), 153-158, 200409
    Link to Paper Search Results by DOI
  121. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
    Link to Paper Search Results by DOI
  122. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
    Link to Paper Search Results by DOI
  123. ★, The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: Crystallographic analysis to elucidate the binding mode of the antibiotic to the protein, JOURNAL OF MOLECULAR BIOLOGY, 360(2), 398-408, 20060707
    Link to Paper Search Results by DOI
  124. ★, Purification and characterization of the second Streptomyces phospholipase A(2) refolded from an inclusion body, PROTEIN EXPRESSION AND PURIFICATION, 50(1), 82-88, 200611
    Link to Paper Search Results by DOI
  125. ★, Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
    Link to Paper Search Results by DOI
  126. ★, Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(12), 9073-9081, 20070323
    Link to Paper Search Results by DOI
  127. ★, Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(11), 2852-2855, 200711
    Link to Paper Search Results by DOI
  128. ★, Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 106(3), 303-305, 200809
    Link to Paper Search Results by DOI
  129. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
    Link to Paper Search Results by DOI
  130. Crystal structure of SCCA1 and insight about the interaction with JNK1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(1), 143-147, 20090227
    Link to Paper Search Results by DOI
  131. A novel transformation system using a bleomycin resistance marker with chemosensitizers for Aspergillus oryzae, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1), 42-47, 20090522
    Link to Paper Search Results by DOI
  132. ★, Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
    Link to Paper Search Results by DOI
  133. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
    Link to Paper Search Results by DOI
  134. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
    Link to Paper Search Results by DOI
  135. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
    Link to Paper Search Results by DOI
  136. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
    Link to Paper Search Results by DOI
  137. Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
    Link to Paper Search Results by DOI
  138. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
    Link to Paper Search Results by DOI
  139. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
    Link to Paper Search Results by DOI
  140. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
    Link to Paper Search Results by DOI
  141. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217
    Link to Paper Search Results by DOI
  142. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
    Link to Paper Search Results by DOI
  143. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 201207
    Link to Paper Search Results by DOI
  144. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
    Link to Paper Search Results by DOI
  145. Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 201304
    Link to Paper Search Results by DOI
  146. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
    Link to Paper Search Results by DOI
  147. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 201311
    Link to Paper Search Results by DOI
  148. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
    Link to Paper Search Results by DOI
  149. Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes, JOURNAL OF ANTIBIOTICS, 68(9), 543-550, 201509
    Link to Paper Search Results by DOI
  150. The structural and mutational analyses of O-ureido-l-serine synthase necessary for d-cycloserine biosynthesis, FEBS JOURNAL, 282(20), 3929-3944, 201510
    Link to Paper Search Results by DOI
  151. High-Level Heterologous Production of D-Cycloserine by Escherichia coli, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(22), 7881-7887, 201511
    Link to Paper Search Results by DOI
  152. Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89(22), 11487-11499, 201511
    Link to Paper Search Results by DOI
  153. Characterization and Mutational Analysis of a Two-Polypeptide Bacteriocin Produced by Citrus Iyo-Derived Lactobacillus brevis 174A, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(12), 1902-1909, 201512
  154. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, 201602
  155. Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 70(5), 582-587, 201605
    Link to Paper Search Results by DOI
  156. Oxidative and Random Cleavage of DNA by the Novel Iron(II)Complex Capable of Yielding an Iron(III)Hydroperoxide Intermediate, Chem. Lett., 1998(1), 39-40, 199801
  157. Bacillopeptins, New Cyclic Lipopeptide Antibiotics from Bacillus subtilis FR-2, J. Antibiotics, 48(10), 1095-1103, 19951025
  158. Effects of Methionine and Cu2+ on the Expression of Tyrosinase Activity in streptomyces castaneoglobisoprus, Journal of Biochemistry, 120(6), 1141-1145, 19961201
  159. Gene Technology to Overproduce the Enzymes Useful as Diagnostic Reagents, 43(8), 765-771, 19950825
  160. Purification and Characterization of a Puromycin-Hydrolyzing Enzyme from Blasticidin S-Producing Streptomyces morookaensis, Journal of Biochemistry, 123(2), 247-252, 19980201
  161. Protection of Mammalian Cells from the Toxicity of Bleomycin by Expression of a Bleomycin-Binding Protein Gene from Streptomyces verticillus, Journal of Biochemistry, 124(4), 835-841, 19981001
  162. A Mammalian Vector carrying the Bleomycin N-Acetyltransefrase Gene from Bleomycin-producing Streptomyces verticillus as a Selective Marker, J. Antibiot., 52(10), 895-899, 19991025
  163. Use of Bleomycin- and Heat Shock-Induced Calreticulin Promoter for Construction of a Mammalian Expression Vector, Journal of Biochemistry, 129(5), 671-674, 20010501
  164. Molecular Cloning of a D-Cycloserine Resistance Gene from D-Cycloserine-producing Streptomyces garyphalus, The Japanese Journal of Antibiotics, 56(9), 762-767, 2003
  165. RBE of HTO to ^<60>Co Gamma-Rays for Cell Killing of A Radioresistant E. coli Harboring Plasmid, Journal of radiation research, 32(3), 286-295, 199109
  166. Molecular Cloning and Expression of Uricase Gene from Arthrobacter globiformis in Escherichia coli and Characterization of the Gene Product(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING), Journal of bioscience and bioengineering, 98(3), 153-158, 20040925
  167. Biosynthetic Correlation between Streptomycin and Mucopeptide in Utilization of D-Glucosamine as a Common Precursor, Journal of fermentation technology, 59(2), 91-96, 19810425
  168. Binding of Streptomycin to the Teichoic Acid of Streptomycin-Producing Streptomyces griseus, Journal of fermentation technology, 60(1), 13-17, 19820225
  169. Ribosomal Resistance to Streptomycin in Strains Regenerated from Protoplasts of a Streptomycin-Susceptible Mutant Derived from a Streptomycin Producer, Journal of fermentation technology, 61(4), 347-351, 19830825
  170. Streptothricin Production by a New Isolate of Streptomyces from Thailand Soil, Journal of fermentation technology, 62(1), 19-28, 19840225
  171. Molecular Cloning and Expression of a Streptomyces Sarcosine Oxidase Gene in Streptomyces lividans, Bioscience, biotechnology, and biochemistry, 56(3), 432-436, 19920323
  172. High Level Expression of Human Transforming Growth Factor α Gene in Escherichia coli in a Fusion Gene System with Human Growth Hormone Gene, Journal of fermentation and bioengineering, 71(4), 216-220, 19910425
  173. Expression of an Artificial Gene Coding for a Human Secretin Precursor-Like Peptide in Escherichia coli, Journal of fermentation and bioengineering, 72(3), 179-182, 19910925
  174. Molecular Cloning and High Expression of the Bacillus Creatinase Gene in Escherichia coli, Journal of fermentation and bioengineering, 76(2), 77-81, 19930825
  175. Cloning, Sequencing, and Overexpression in Escherichia coli of a Sarcosine Oxidase-Encoding Gene Linked to the Bacillus Creatinase Gene, Journal of fermentation and bioengineering, 77(3), 231-234, 19940325
  176. Development of a Useful Vector System That Enables Visual Detection of Inhibitors of Nucleic Acid Synthesis, Journal of fermentation and bioengineering, 84(2), 155-157, 19970825
  177. A Convenient Method for the Evaluation of Anti-Tumor Agents Affecting the Cell Cycle, Journal of bioscience and bioengineering, 90(5), 574-576, 20001125
  178. Molecular and Structural Biology of Bleomycin and Its Resistance Determinants, Journal of bioscience and bioengineering, 93(2), 105-116, 20020225
  179. Mechanisms of resistance to antibiotics in actinomycetes., Hakkokogaku Kaishi, 69(4), 253-270, 19910725
  180. Structure and function of blmA gene of bleomycin-producing microorganism, 3, 19911010
  181. Overexpression of a Protein Induced by Bleomycin in Escherichia coli, 3, 19911010
  182. Mechanism of self-protection in a puromycin-producing microorganism, 59, 19841118
  183. Mechanism of self-protection in a streptomycin-producing microorganism, 59, 19841118
  184. Molecular cloning of a streptomycin6-kinase gene from the streptomycin-producing Streptomyces griseus, 59, 19841118
  185. Develpoment of cloning vectors which can be used in many of the antibiotic-producing microorganisms, 59, 19841118
  186. Pleiotropic Mutation in A-Factor Independent Strain of Streptomyces griseus, 60, 19851015
  187. Molecular breeding of the antibiotic-producing microorganisms by introduction of the drug resistant genes, 60, 19851015
  188. Acetylation of Blasticidin S by the producing microorganism, 60, 19851015
  189. Pleiotropic mutation in Streptomyces griseus independent of A-factor, 62, 19871102
  190. Two genes of streptomycin kinasein a streptomycin producer, 62, 19871102
  191. The Nucleotide Sequence of Streptomycin 6-kinase gene, 61, 19861117
  192. Development of a coupled transcription-translation system in Streptomyces griseus., 61, 19861117
  193. Isolation and characterization of blasticidin S acetylating enzyme in a blasticidin S producer., 61, 19861117
  194. Genetic Studies on Differentiation in a Streptomycete Strain Independent of A-factor., 61, 19861117
  195. Self-resistance mechanisms in antibiotic-proucing microorganisms, 2, 19901010
  196. Activation of the ERKs pathway prevents susceptibility to the H_2O_2-induced apoptosis in human pancreatic cancer cell line., 11, 19990816
  197. Structure and function of a gene encoding a puromycin-inactivating enzyme from Streptomyces morookaensis, 11, 19990816
  198. Structure and function of a D-cycloserine(Cs)-biosynthetic gene operon from Cs-producing Streptomyces lavendulae, 11, 19990816
  199. The 1.6Å crystal structure of Streptomyces violaceoruber phospholipase A_2 binding calcium ion., 11, 19990816
  200. Crystal struture of bleomycin-binding protein, BLMT, complexed with bleomycin, 11, 19990816
  201. Crystal structure of a novel phospholipase A_2 from Streptomyces violaceoruber, 10, 19980831
  202. Expression of a bleomycin-resistance gene blmB from Streptomyces in mammalian cells and construction of cloning vector useful in E.coli., 10, 19980831
  203. Site-directed mutagenesis study of a blomycin-binding protein, BLMA, from Streptomyces verticillus., 10, 19980831
  204. Molecular cloning and characterization of D-cycloserine resistance gene from D-cycloserine-producing microorganisms., 10, 19980831
  205. Crystal struture of bleomycin-binding protein (BLMT) from Tn5, 10, 19980831
  206. Protein engineering for human pancreatic PhospholipaseA_2., 10, 19980831
  207. Analysis of bleomycin-inducible genes in human lung fibroblast., 12, 20000710
  208. Analysis of bleomycin-inducible genes in human normal lung fibroblasts, 13, 20010824
  209. 569 Bleomycin-induced arbekacin resistance in methicillin resistant Staphylococcus aureus (MRSA), 6, 19941010
  210. Molecular cloning of a Streptomyces cholesterol esterase gene, 4, 19921010
  211. Overexpression of a protein induced by bleomycin in Eschericha coli, 4, 19921010
  212. Functional analysis of the bleomycin-resistance gene product from transposon Tn5, 9, 19970905
  213. Mechanism of high level resistance to arbekacin in methicillin-resistant Staphylococcus aureus., 9, 19970905
  214. Expression of bleomycin-resistance gene from Streptomyces in mammalian cells, 8, 19960905
  215. Purification and characterization of the puromycin-inactivating enzyme from S. morookaensis., 8, 19960905
  216. 946 Blepharismin, a photoreceptor pigment from Blepharisma enhances the antibacterial activity of arbekacin in MRSA, 8, 19960905
  217. The bleomycin-binding protein induces the expression of tac promoter controlled gene, 7, 19950915
  218. Development of an intelligent vector to screen antibiotics which inhibit the synthesis of nucleic acids, 7, 19950915
  219. Overexpression of β-lactamase induced by bleomycin in Escherichia coli, 7, 19950915
  220. Blasticidin S-producing Streptomyces morookaensis possesses a novel enzyme which hydrolyzes puromycin., 7, 19950915
  221. RESISTANCE MECHANISMS TO STREPTOMYCIN IN STREPTOMYCIN-PRODUCING STREPTOMYCES GRISEUS, Journal of pharmacobio-dynamics, 4(4), "s-45", 198104
  222. Novel Assay System Favorable for the Study of Cell-to-Cell Transmission of HIV-1 and Its Application to the Evaluation of Anti-HIV Drugs, Biological & pharmaceutical bulletin, 18(6), 920-922, 19950615
  223. Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity, Biological & pharmaceutical bulletin, 18(7), 996-1000, 19950715
  224. Molecular Cloning and Characterization of Gene Encoding Novel Puromycin-Inactivating Enzyme from Blasticidin S-Producing Streptomyces morookaensis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING), Journal of bioscience and bioengineering, 101(1), 63-69, 20060125
  225. (244) Immune-function and Colonization on Plants of Lacto Acetic Bacteria Pediococcus pentosaceus KMC05 Selected as an Biocontrol Agent against Fusarium Wilt of Spinach(Abstract of the Paper Presented at the 2006 Annual Meeting in Sapporo), Annals of the Phytopathological Society of Japan, 72(4), 266-267, 20061125
  226. Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING), Journal of bioscience and bioengineering, 106(3), 303-305, 20080925
  227. 1G09-4 Kinetic studies of tyrosinase inhibitors contained in sake lees, 18, 20060803
  228. 1012 Analysis of the bleomycin responsive genes in the human normal lung fibroblasts, 14, 20020925
  229. 541 Survival advantage of Escherichia coli caused by a bleomycin resistance gene from Tn5, 14, 20020925
  230. 2B10-3 Cloning and characterization of a PTPase gene (ptpB) from Streptomyces lavendulae, 16, 20040825
  231. 3A10-4 Physio-chemical characterization of recombinant uricase from Arthrobacter globiformis, 16, 20040825
  232. 2A16-1 Characterization of a Streptomyces D-alanyl-D-alanine ligase as a target of D-cycloserine and as a D-cycloserine-resistance determinant, 16, 20040825
  233. 2A15-5 Structural biology of an alanine racemase from D-cycloserine-producing microorganism, 16, 20040825
  234. 1pB17-2 Cloning and functional analysis of a blue pigment biosynthetic gene from D-cycloserine-producing Streptomyces lavendulae, 16, 20040825
  235. 2H10-3 Transcriptional regulation of the secondary metabolite-encoding genes in Streptomyces lavendulae ATCC11924, 18, 20060803
  236. 2H10-2 Functional analysis of the tyrosine-phosphorylated proteins expressed in Streptomyces coelicolor A3 (2), 18, 20060803
  237. 3F11-4 The Mitomycin C (MMC)-binding Protein from MMC-producing Microorganisms Protects from the Lethal Effect of Bleomycin, 18, 20060803
  238. 1C10-2 Mutational analysis of BPSA, a single module type NRPS catalyzing indigoidine synthesis, 19, 20070802
  239. 1C10-1 A substrate-binding mode of bleomycin N-acetyltransferase, 19, 20070802
  240. 2E09-1 Sequence analysis and structural organization of four plasmids from bacteriocin-producing Lactobacillus brevis 925A, 19, 20070802
  241. 1Bp21 A proposed regulatory mechanism for the biosynthesis of a class IIb bacteriocin brevicin 174A, 21, 20090825
  242. 2Da08 Crystal structure of a Streptomyces serine O-acetyltransferase responsible for the biosynthesis of D-cycloserine, 21, 20090825
  243. 2Ma06 Molecular breeding of 2-phenylethanol-producing Lactobacillus plantarum, 21, 20090825
  244. 1P-015 Analysis of the dcsA gene responsible for N^ω-hydroxy-L-arginine formation in the biosynthesis of D-cycloserine, 65, 20130825
  245. 1P-069 Identification of the residues important for catalytic expression of O-ureido-L-serine synthase, DcsD, found in D-cycloserine biosynthetic pathway, 65, 20130825
  246. 2P-222 Identification of an enzyme catalyzing the deamino-acylation of leucylblasticidin S, 65, 20130825
  247. 1P-047 Development of a system producing highly an anti-tubercular antibiotic D-cycloserine in E. coli, 66, 20140805
  248. Improvement of constipation and liver function by plant-derived lactic acid bacteria : A double-blind, randomized trial, Nutrition, 26(4), 367-374, 201004
  249. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLoS ONE, 7(2), 2012
  250. Intracellular accumulation of trehalose during streptomycin formation by Streptomyces griseus., Bioscience, Biotechnology, and Biochemistry, 48(2), 285-290, 1984
  251. Correlation between intracellular accumulation of peptidoglycan precursors and streptomycin formation., Bioscience, Biotechnology, and Biochemistry, 48(2), 291-297, 1984
  252. In vivo cloning of arylsulfatase-tyramine oxidase genes in rec strains of Klebsiella aerogenes., Bioscience, Biotechnology, and Biochemistry, 47(8), 1807-1815, 1983
  253. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, Journal of Pharmacobio-Dynamics, 33(2), 289-293, 2010
  254. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, Journal of Pharmacobio-Dynamics, 33(10), 1673-1679, 2010
  255. Bacillopeptins, New Cyclic Lipopeptide Antibiotics from Bacillus subtilis FR-2., The Japanese Journal of Antibiotics, 48(10), 1095-1103, 1995
  256. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain., The Japanese Journal of Antibiotics, 34(9), 1183-1188, 1981
  257. Effect of arginine on gramicidin S biosynthesis by Bacillus brevis., The Japanese Journal of Antibiotics, 35(5), 615-621, 1982
  258. Isolation and properties of a puromycin acetyltransferase from puromycin-producing Streptomyces alboniger., The Japanese Journal of Antibiotics, 38(12), 1761-1766, 1985
  259. Acetylation of blasticidin S by its producing actinomycetes., The Japanese Journal of Antibiotics, 39(6), 827-832, 1986
  260. Isolation and properties of a blasticidin S acetylating enzyme from a producer organism., The Japanese Journal of Antibiotics, 42(1), 135-137, 1989
  261. Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content., Actinomycetologica, 16(2), 17-20, 2002
  262. Streptomycin biosynthesis and self-resistance mechanism in streptomycin-producing Streptomyces griseus., Actinomycetologica, 4(1), 15-22, 1990
  263. Oral lactic acid bacteria related to the occurrence and/or progression of dental caries in Japanese preschool children, Bioscience and Microflora, 0(0), 29-36, 2015
  264. Mechanism of Protection of Protein Synthesis Against Streptomycin Inhibition in a Producing Strain, Journal of Antibiotics, 34(9), p1183-1188, 198109
  265. Crystallographic and mutational analyses of cystathionine beta-synthase in the H2S-synthetic gene cluster in Lactobacillus plantarum, PROTEIN SCIENCE, 26(4), 763-783, 201704
    Link to Paper Search Results by DOI
  266. Characterization of Exopolysaccharides Produced by Thermophilic Lactic Acid Bacteria Isolated from Tropical Fruits of Thailand, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(5), 621-629, 201705
  267. Activation Mechanism of the Streptomyces Tyrosinase Assisted by the Caddie Protein, BIOCHEMISTRY, 56(41), 5593-5603, 20171017
    Link to Paper Search Results by DOI
  268. Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance -The Need for Cooperation between the Pharmacy and the University in Genetic Testing-, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(12), 1517-1531, 201712
  269. Expression of Genes Involved in Bacteriocin Production and Self-Resistance in Lactobacillus brevis 174A Is Mediated by Two Regulatory Proteins, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84(7), 201804
    Link to Paper Search Results by DOI
  270. Characterization of the SN35N Strain-Specific Exopolysaccharide Encoded in the Whole Circular Genome of a Plant-Derived &ITLactobacillus&IT &ITplantarum&IT, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41(4), 536-545, 201804
  271. A novel structure of exopolysaccharide produced by a plant-derived lactic acid bacterium Lactobacillus paracasei IJH-SONE68, JOURNAL OF BIOCHEMISTRY, 164(2), 87-92, 201808
    Link to Paper Search Results by DOI
  272. Catalytic mechanism of the tyrosinase reaction toward the Tyr(98) residue in the caddie protein, PLOS BIOLOGY, 16(12), 201812
    Link to Paper Search Results by DOI
  273. Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis, MOLECULES, 24(16), 201908
    Link to Paper Search Results by DOI
  274. Development of a System of High Ornithine and Citrulline Production by a Plant-Derived Lactic Acid Bacterium, Weissella confusa K-28, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(9), 1581-1589, 201909
    Link to Paper Search Results by DOI
  275. Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human, JOURNAL OF ANTIBIOTICS, 72(11), 834-842, 201911
    Link to Paper Search Results by DOI
  276. Improvement of Alcohol-Poisoning Symptoms in Mice by the Oral Administration of Live Lactobacillus plantarum SN13T Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(5), 202003
    Link to Paper Search Results by DOI
  277. Interleukin-8 Release Inhibitors Generated by Fermentation ofArtemisia princepsPampanini Herb Extract WithLactobacillus plantarumSN13T, FRONTIERS IN MICROBIOLOGY, 11, 20200603
    Link to Paper Search Results by DOI
  278. Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for d-cycloserine biosynthesis, FEBS JOURNAL, 287(13), 2763-2778, 202007
    Link to Paper Search Results by DOI
  279. Catalytic specificity of the Lactobacillus plantarum cystathionine gamma-lyase presumed by the crystallographic analysis, SCIENTIFIC REPORTS, 10(1), 20200910
    Link to Paper Search Results by DOI
  280. Molecular cloning and characterization of gene encoding novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 101(1), 63-69, 200601
    Link to Paper Search Results by DOI
  281. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 201207
    Link to Paper Search Results by DOI
  282. ★, A novel transformation system using a bleomycin resistance marker with chemosensitizers for Aspergillus oryzae, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1), 42-47, 20090522
    Link to Paper Search Results by DOI
  283. Crystal structure of SCCA1 and insight about the interaction with JNK1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(1), 143-147, 20090227
    Link to Paper Search Results by DOI
  284. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
    Link to Paper Search Results by DOI
  285. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
    Link to Paper Search Results by DOI
  286. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(11), 2852-2855, 200711
    Link to Paper Search Results by DOI
  287. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 201311
    Link to Paper Search Results by DOI
  288. Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
    Link to Paper Search Results by DOI
  289. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
    Link to Paper Search Results by DOI
  290. Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
    Link to Paper Search Results by DOI
  291. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
    Link to Paper Search Results by DOI
  292. Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 201304
    Link to Paper Search Results by DOI
  293. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
    Link to Paper Search Results by DOI
  294. Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
    Link to Paper Search Results by DOI
  295. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
    Link to Paper Search Results by DOI
  296. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
    Link to Paper Search Results by DOI
  297. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
    Link to Paper Search Results by DOI
  298. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
    Link to Paper Search Results by DOI
  299. Purification and characterization of the second Streptomyces phospholipase A(2) refolded from an inclusion body, PROTEIN EXPRESSION AND PURIFICATION, 50(1), 82-88, 200611
    Link to Paper Search Results by DOI
  300. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
    Link to Paper Search Results by DOI
  301. The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: Crystallographic analysis to elucidate the binding mode of the antibiotic to the protein, JOURNAL OF MOLECULAR BIOLOGY, 360(2), 398-408, 20060707
    Link to Paper Search Results by DOI
  302. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
    Link to Paper Search Results by DOI
  303. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
    Link to Paper Search Results by DOI
  304. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
    Link to Paper Search Results by DOI
  305. Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 106(3), 303-305, 200809
    Link to Paper Search Results by DOI
  306. Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(12), 9073-9081, 20070323
    Link to Paper Search Results by DOI
  307. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
    Link to Paper Search Results by DOI
  308. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217
    Link to Paper Search Results by DOI

Publications such as books

  1. 1994/12/14, Antibiotics produced by ┣DBStreptomyces(/)-┫DB host-vector systems. , In Recombinant Microbes for industrial and agricultural applications, marcel dekker= inc., 1994, 12, Scholarly Book, Joint work, en, 896
  2. 2012/09, Advanced Technology for Microbiological Production in Japan, 微生物の物質資産について，その技術，応用の最新の状況, 2012, 10, Scholarly Book, Joint work, jp, ISBN-10:4781306586,ISBN-13:978-4781306582, 223, p186-193
  3. 2014, Microbiol Production , From Genome Design to Cell Engineering Structure of Tyrosinase and Its Inhibitor from Sake Lees, Springer, 2014, Scholarly Book, Joint work, en, Anazawa, H. ; Shimizu, S. (Eds.) , 978-4-431-54606-1, 306, pp.243-249

Awards

  1. 2011/09/04, The 14th John M. Kinney Award for General Nutrition, The Nutritional Sciences,Education & Research Fund (NSERF) と国際栄養科学雑誌「Nutrition」との連名, 植物乳酸菌が便秘と肝機能の改善に優れていることのヒト臨床試験による実証

Patented

  1. Patent, TW：I727293, 2021/05/11, COMPOSITION FOR TYPE IV ALLERGY
  2. Patent, CA：3086031, 2021/11/23, COMPOSITION FOR TYPE IV ALLERGY
  3. Patent, AU：2019260953, 2021/05/06, COMPOSITION FOR TYPE IV ALLERGY
  4. Patent, KR：10-2368628, 2022/02/23, COMPOSITION FOR TYPE IV ALLERGY
  5. Patent, EP：3714701, 2022/08/10, COMPOSITION FOR TYPE IV ALLERGY
  6. Patent, 6679202, 2020/03/23, COMPOSITION FOR TYPE IV ALLERGY
  7. Patent, TW：I739078, 2021/09/11, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  8. Patent, CA：3086024, 2022/02/08, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  9. Patent, AU：2019260952, 2021/02/25, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  10. Patent, KR：10-2368627, 2022/02/23, COMPOSITION FOR SUPPRESSING FAT ACCUMULATION
  11. Patent, 6649539, 2020/01/21, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  12. Patent, TW：I746955, 2021/11/21, COMPOSITION FOR TYPE I ALLERGY
  13. Patent, CA：3085995, 2022/03/08, COMPOSITION FOR TYPE I ALLERGY
  14. Patent, AU：2019260951, 2021/03/25, COMPOSITION FOR TYPE I ALLERGY
  15. Patent, KR：10-2368626, 2022/02/23, COMPOSITION FOR TYPE I ALLERGY
  16. Patent, 6648348, 2020/01/17, COMPOSITION FOR TYPE I ALLERGY
  17. Patent, TW：I713850, 2020/12/21, Nobel lactic acid bacteria and use thereof
  18. Patent, NZ：750198, 2022/10/04, Nobel lactic acid bacteria and use thereof
  19. Patent, CA：3032579, 2020/06/16, Nobel lactic acid bacteria and use thereof
  20. Patent, AU:2018281512, 2020/07/09, Nobel lactic acid bacteria and use thereof
  21. Patent, KR：10-2361556, 2022/02/07, Nobel lactic acid bacteria and use thereof
  22. Patent, 6523579, 2019/05/10, Nobel lactic acid bacteria and use thereof
  23. Patent, TW:I696465, 2020/06/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  24. Patent, NZ: 750188, 2022/08/02, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  25. Patent, CA:3032572, 2020/04/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  26. Patent, AU:2018281511, 2020/07/30, NEW LACTIC ACID BACTERIUM AND THEREOF
  27. Patent, KR:10-2313677, 2021/10/12, NEW LACTIC ACID BACTERUM AND USE THEREOF
  28. Patent, US:11447740, 2022/09/20, NEW LACTIC ACID BACTERUM AND USE THEREOF

Social Activities

Organizing Academic Conferences, etc.

  1. Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/03, 2009/03
  2. The 2nd International Symposium for Lactic Acid Bacteria to Prevented to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/12, 2009/12
  3. The 3rd International Symposium for Lactic Acid Bacteria to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2010/12, 2010/12
  4. The 4th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2011/12, 2011/12
  5. The 5th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2012/12, 2012/12
  6. The 2013 Annual Meeting of the Society for Actinomycetes Japan Abstracts, 2013/09, 2013/09
  7. The 6th International Symposium for Probiotics to preventive & Pre-symptomatic Medicine, Representative, 2014/03, 2014/03
  8. 2014 Annual Meeting of The Japan Society for Lactic Acid Bacteria, 2014/07, 2014/07