MASANORI SUGIYAMA

Last Updated :2024/02/13

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor, Collaborative Research Laboratory
Web Site
E-mail
sugihiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5280 FAX : (+81)82-257-5284
Self-introduction
I (Professor Sugiyama) have studied on the self-resistance mechanisms in antibiotic-producing actinomyces during 40 years. My boss, who had employed me as a assistant professor, has always encouraged me at the following phrase: "If you will continue the study for 10 years, you will be an expert at the microbiology field. Furthermore, if you will continue the study as your lifework, you will become an authority at the scientific field.

Basic Information

Major Professional Backgrounds

  • 1987/05/01, Institute Pasteur Paris, Microbiolgy Unit, Researcher
  • 1992/04/01, Hiroshima University, Faculty of Medicine, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Engineering, Japan, 1974/04, 1976/03
  • Hiroshima University, Faculty of Engineering, Japan, 1971/04, 1974/03

Academic Degrees

  • Doctor of Engineering, Hiroshima University
  • Master of Engineering, Hiroshima University

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Natural medicines

Research Keywords

  • X-ray crystallography
  • three dimensional analysis of protein by X-ray
  • actinomycetes
  • plant-derived lactic acid bacteria
  • molecular microbiology
  • gene regulation sciences
  • antibiotics
  • probiotics
  • secondary metabolite

Affiliated Academic Societies

  • The Society for Biotechnology,Japan
  • The Phamaceutical Society of Japan
  • Japanese Society for Bachteriology
  • The Society for Actinomycetes Japan
  • Japan Society for Lactic Acid Bacteria
  • ASBMB (The American Society for Biochemistry and Molecular Biology)
  • Japan Bioindustiry Association

Educational Activity

Course in Charge

  1. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced research on Probiotic Science for Preventive Medicine
  2. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced research on Probiotic Science for Preventive Medicine
  3. 2023, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  4. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  5. 2023, Graduate Education (Master's Program) , 4Term, Lecture on Probiotic Science for Preventive Medicine
  6. 2023, Graduate Education (Master's Program) , First Semester, Seminar on Probiotic Science for Preventive Medicine
  7. 2023, Graduate Education (Master's Program) , Second Semester, Seminar on Probiotic Science for Preventive Medicine
  8. 2023, Graduate Education (Master's Program) , First Semester, Research on Probiotic Science for Preventive Medicine
  9. 2023, Graduate Education (Master's Program) , Second Semester, Research on Probiotic Science for Preventive Medicine
  10. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Probiotic Science for Preventive Medicine
  11. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Probiotic Science for Preventive Medicine
  12. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  13. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  14. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Probiotic Science for Preventive Medicine
  15. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Probiotic Science for Preventive Medicine

Award of Education

  1. 2014/11/03

Research Activities

Academic Papers

  1. Fermented stevia improves alcohol poisoning symptoms associated with changes in mouse gut microbiota, Nutrients, 15(3708), 20230824
  2. Role of phenolic acid metabolism in enhancing bioactivity of mentha extract fermented with plant-derived Lactobacillus plantarum SN13T, Probiotics Antimicrob Proteins, 202306
  3. Awareness Survey on Genetic Testing among Pharmacists in Hiroshima City, JAPANESE JOURNAL OF SOCIAL PHARMACY, Vol 41(No,1), 56-68, 2022
  4. A novel prokaryotic phospholipase A(2) - Characterization, gene cloning, and solution structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20051-20058, 20020531
  5. Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1778(1), 33-41, 200801
  6. Susceptibility of protein synthesis to streptomycin in streptomycin-producing ., FEBS Letters, 250-252, 19800401
  7. Assessment of competitive action of streptomycin 6-kinase and streptomycin 6-phosphatase in the in vitro protein synthesis of a streptomycin-producing microorganism., FEBS Letters, 331-333, 19820401
  8. Molecular cloning and expression in of a streptomycin 6-phosphotransferase gene from a streptomycin-producing microorganism., FEBS Letters, 385-389, 19850401
  9. Susceptibility of protein synthesis to neomycin in neomycin-producing ., Journal of General Microbiology(U. K. )=, 477-478, 19800401
  10. Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin producing microorganism., Journal of General Microbiology(U. K. )=, 1683-1687, 19830401
  11. Mechanism of self-protection in a puromycin-producing microorganism., Journal of General Microbiology(U. K. )=, 1999-2005, 19850401
  12. The nucleotide sequence of a streptomycin 6-phosphotransferase gene from a streptomycin producer., Journal of General Microbiology(U. K. )=, 1289-1296, 19870401
  13. Use of the tyrosinase gene from to probe promoter sequences for ., Plasmid(U. S. A), 237-241, 19900401
  14. Plasmid involvement in the degradation of polycyclic aromatic hydrocarbons by a Beijerinckia species., Biochemical and Biophysical Research Communications, 939-945, 19830401
  15. Biosynthetic correlation between streptomycin and mucopeptide in utilization of D-glucosamine as a common precursor., Journal of Fermentation Technology, 91-96, 19810401
  16. Binding of streptomycin to the teichoic acid of streptomycin-producing ., Journal of Fermentation Technology, 13-17, 19820401
  17. Ribosomal resistance to streptomycin in strains regenerated from protoplasts of a streptomycin-susceptible mutant derived from a streptomycin producer., Journal of Fermentation Technology, 347-351, 19830401
  18. Streptothricin production by a new isolate of from Thailand soil., Journal of Fermentation Technology, 19-28, 19840401
  19. In vivo cloning of arylsulfatase-tyramine oxidase genes in rec strains of ., Agricultural and Biological Chemistry, 1807-1815, 19830401
  20. Intracellular accumulation of trehalose during streptomycin formation by ., Agricultural and Biological Chemistry, 285-290, 19840401
  21. Correlation between intracellular accumulation of peptideglycan precursors and streptomycin formation., Agricultural and Biological Chemistry, 291-297, 19840401
  22. Molecular cloning and expression of a sarcosine oxidase gene in ., Bioscience= Biotechnology and Biochemistry, 432-436, 19920401
  23. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain., Journal of Antibiotics, 1183-1188, 19810401
  24. Effect of arginine of gramicidin S biosynthesis by< Bacillus>., Journal of Antibiotics, 615-621, 19820401
  25. Isolation and properties of a puromycin acetyltransferase from puromycin-producing ., Journal of Antibiotics, 1761-1766, 19850401
  26. Acetylation of blasticidin S by its producing actinomycetes., Journal of Antibiotics, 827-832, 19860401
  27. Isolation and properties of a blasticidin S acetylating enzyme from a producer organism., Journal of Antibiotics, 135-137, 19890401
  28. The primary structure of an acidic ribosomal protein from ., Biochimica et Biophysica Acta, 164-172, 19820401
  29. Fate of streptomycin in mycelium of the producer organism., Biotechnology Letters(U. K. ), 239-244, 19810401
  30. Roles of streptomycin 6-kinase and ribosomal affinity to streptomycin in self-protection of streptomycin producer., Biotechnology Letters(U. K. ), 357-362, 19810401
  31. Mechanism of resistance to streptothricin of a producing microorganism., Biotechnology Letters(U. K. ), 441-446, 19830401
  32. Protoplast formation and the regeneration of ATCC9999 and its mutants., Biotechnology Letters(U. K. ), 709-714, 19830401
  33. Overproduction of human insulin-like growth factor-(]G0002[) in ., Biotechnology Letters(U. K. ), 839-844, 19890401
  34. Kinetic studies of streptomycin uptake implicated in selfresistance in a streptomycin producer., Biotechnology Letters(U. K. ), 1-6, 19900401
  35. Silence of streptomycin 6-phosphotransferase gene derived by incubation at a high temperature in ., Biotechnology Letters(U. K. ), 537-542, 19910401
  36. Efficient purification and analysis for stability of human secretin precursor-like peptide produced in ., Biotechnology Letters(U. K. ), 603-608, 19910401
  37. Expression of an artificial gene coding for a human secretin precursor-like peptide in ., Journal of Fermentation and Bioengineering, 179-182, 19910401
  38. Two genes for streptomycin phosphotransferase in ., 353-358, 19880401
  39. Isolation and properties of the axopodial cytoskelton of a heliozoan, ., European Journal of Ptotistology, 214-219, 19920401
  40. Electrophoretic migration of the heliozoan, ., Cytobios(U. K. ), 107-114, 19840401
  41. Streptomycin biosynthesis and self-resistance mechanism in streptomycin-producing ., Actinomycetol., 15-22, 19900401
  42. Resistant mechanism to blasticidin S in ., Korean Biochemical Journal, 327-330, 19910401
  43. Mechanism of self-protection and genes coding for antibiotic biosynthesis , particularly, in microorganisms which produce antibiotic inhibitors of protein synthesis., J. Kor. Agric. Chem. Soc., 371-375, 19880401
  44. Ultrastructure and calcium-dependent contraction of the myonemal network in a heterotrich ciliate, ., European Journal of Ptotistology, 279-287, 19920401
  45. Structure and function of the cytoskeleton in Heliozoa : 2. Measurement of the force of rapid axopodial contraction in Echinosphaerium., European Journal of Ptotistology, 430-433, 19920401
  46. Molecular cloning and high expression of the creatinase gene in ., Journal of Fermentation and Bioengineering, 77-82, 19930401
  47. Susceptibility of methicillin-resistant clinical isolates to various antimicrobial agents. III. Novel. inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima Journal of Medical Sciences, 101-107, 19930401
  48. Cloning, sequencing, and overexpression in of a sarcosine oxidase-encoding gene linked to the creatinase gene., Journal of Fermentation and Bioengineering, 231-234, 19940401
  49. Expression of c-kit ligand in human keratinocytes., Arch Dermatol Res., 273-277, 19940401
  50. Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus, FEMS Microbiology Letters, 121, 81-86, 19940401
  51. Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin, Gene, 11-16, 19940401
  52. Uracil-targeted inhibition of poly(A)-poly(U) hybridization by a zinc(II)-cyclen complex., Chem. Commun., 1747-1748, 19940401
  53. Overproduction of the bleomycin-binding proteins from bleomycin-producing Streptomyces verticillus and a methicillin-resistant Staphylococcus aureus in Escherichia coli andtheir immunological characterisation, FEBS Lett, 80-84, 19950401
  54. Novel assay system favorable for the study of cell-to-cell transmission of HIV-1 and its application to the evaluation of anti-HIV drugs., Biological and Pharmaceutical Bulletin, 18, 920-922, 19950401
  55. Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity., Biological and Pharmaceutical Bulletin, 18, 996-1000, 19950401
  56. Dimeric macrocyclic polyamines with potent inhibitory activity against human immunodeficiency virus., Antiviral Chemistry and Chemotherapy, 6, 337-344, 19950401
  57. The photoreceptor pigment of the unicellular organism Blepharisma generates hydroxyl radicals., Journal of Photochemistry and Photobiology, B:Biology34, 29-33, 19960401
  58. Expression of multiple forms of fetal liver kinase-2 (flk-2/flk-3) ligand in cultured human keratinocytes., Arch Dermatol Res., 289, 177-179, 19970401
  59. Development of a useful vector system that enables visual detection of inhibitor of nucleic acid synthesis, J. Ferment. Bioeng., 84, 155-157, 19970401
  60. Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus, FEMS Microbiol. Lett., 155(67), 71, 19970401
  61. Oxidative and random cleavage of DNA by the novel iron(II)complex capable of yielding an iron(III)hydroperoxide intermediate., Chem. Lett., 39-40, 19980401
  62. Protection of mammalian cells from the toxicity of bleomycin by expression of a bleomycin-binding protein gene from Streptomyces verticillus, J. Biochem., 124, 835-841, 19980401
  63. Characterization of the bleomycin resistance determinant ercoded on the Tn5, FEBS Lett, 442, 34-38, 19990401
  64. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5., Acta Cryst. Sec., D55, 1095-1097, 19990401
  65. Mutation of the N-terminal Proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin, FEBS Lett, 450, 227-230, 19990401
  66. Synthesis, Spectroscopic, Redox Properties, and DNA cleavage Activity of Low-spin Iron((]G0003[))complexes of Bleomycin Analogues., Inorgania Chimica Acta, 294, 56-61, 19990401
  67. Growth of human pancreatic cancer cells, induced by human pancreatic phospholipase A2, is mediated via its specific receptor but not via its catalytic property, INTERNATIONAL JOURNAL OF ONCOLOGY, 9, 1219-1225, 19961201
  68. Human pancreatic phospholipase A2 stimulates the growth of human pancreatic cancer cell line, FEBS Letters, 373, 85-87, 19951001
  69. Gene technology to overproduce the enzymes useful as diagnostic reagents, 43(8), 765-771, 19950801
  70. Ultrastracture and rapid axopodial contraction of a heliozoa, Raphidiophrys contractilis sp. nov., Journal of Eukaryotic Microbiology, 42(3), 283-288, 19950501
  71. Susceptibility of Methicillin-resistant Staphylococcus aureus clinical isolates to various antimicrobial agents. III. Novel, inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima J. Med. Sci., 42, 101-107, 19930101
  72. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1., J. Basic Microbiol., 42, 190-200, 20020401
  73. Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content, Actinomycetologica, 16(2), 17-20, 20020401
  74. Atomic resolution structure of the prokaryotic phospholopase A2: Molecular motion and implication for catalytic mechanism., PROTEINS: Structure= Function= and Genetics, 51(3), 453-469, 20030501
  75. Molecular and structural biology of bleomycin and its resistance determinants., J. Bioscience and Bioengineering, 93, 105-116, 20020401
  76. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, J. Antibiotics, 56, 762-767, 20030401
  77. Physical stress by magnetic force accelerates differentiation of human osteoblasts, Biochem. Biophys. Res. Common, 32-38, 20030401
  78. Molecular cloning and expression of uricase gene from Arthrobactor globiformis in Escherichia coli and characterization of the gene product, J. Biosc. Bioeng.=, 153-158, 20040401
  79. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castanepglobisporus, Protein Expr Purif, 34, 202-207, 20040401
  80. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, Bioscience, Biotechnology, and Biochemistry, 71(11), 2852-2855, 20071101
  81. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat., In Vitro Cell Dev Biol Anim, 39(1-2), 89-97, 20030101
  82. A novel assay method for an amino acid racemase reaction based on circular dichroism, Biochem. J., 389, 491-496, 20050701
  83. Self-protection mechanisms of antibiotic-producing microorganisms, Nippon rinsyo, 65, 669-673, 20070228
  84. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5, Acta Crystallogr. Sect. D, 55, 1095-1097, 19990501
  85. A mammalian vector carrying the bleomycin N-acetyltransferase gene from Streptomyces verticillus as a selective marker, J. Antibiot., 52, 895-899, 19990401
  86. Molecular and structural biology of bleomycin and its resistance determinants, J. Biosci. Bioeng., 93, 105-116, 20020401
  87. Effects of methionine and Cu2+ on the expression of tyrosinase activity in Streptomyces castaneoglobisporus., J. Biochem., 120(6), 1141-1145, 19961201
  88. Molecular cloning and characterization of a gene encoding a novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis., J. Biosci. Bioeng., 101(1), 63-69, 20061101
  89. Establishment of an in vitro Peyer's patch cell culture system correlative to in vivo study using intestine and screening of lactic acid bacteria enhancing intestinal immunity., Biol. Pharm. Bull., 33(2), 289-293, 20100201
  90. ★, Crystal structure of SCCA1 and insight about the interaction with JNK1., Biochem. Biophys. Res. Commun., 380(1), 143-147, 20090201
  91. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im., Biochem. Biophys. Res. Commun., 378(3), 574-548, 20090101
  92. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS: Structure= Function= and Genetics, 79(10), 2999-3005, 20110901
  93. Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line., FEBS Letters, 407, 343-346, 19970501
  94. The 1.5 angstrom crystal structure of a bleomycin resistance determinant from bleomycin-producing Streptomyces verticillus, JOURNAL OF MOLECULAR BIOLOGY, 295(4), 915-925, 20000128
  95. A novel approach to gene therapy of albino hair in histoculture with a retroviral Streptomyces tyrosinase gene, PIGMENT CELL RESEARCH, 13(5), 345-351, 200010
  96. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 90(5), 574-576, 200011
  97. Crystallization and preliminary X-ray diffraction studies of Streptomyces phospholipase A(2) in a calcium-binding form, JOURNAL OF INORGANIC BIOCHEMISTRY, 82(1-4), 221-223, 200011
  98. Use of bleomycin- and heat shock-induced calreticulin promoter for construction of a mammalian expression vector, JOURNAL OF BIOCHEMISTRY, 129(5), 671-674, 200105
  99. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 9992-9999, 20010330
  100. The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(3), 2311-2320, 20020118
  101. Molecular and structural biology of bleomycin and its resistance determinants, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93(2), 105-116, 200202
  102. The crystal structure of prokaryotic phospholipase A(2), JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20059-20069, 20020531
  103. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1, JOURNAL OF BASIC MICROBIOLOGY, 42(3), 190-200, 2002
  104. Physical stress by magnetic force accelerates differentiation of human osteoblasts, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 311(1), 32-38, 20031107
  105. Atomic resolution structure of prokaryotic phospholipase A(2): Analysis of internal motion and implication for a catalytic mechanism, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 51(3), 453-469, 20030515
  106. Molecular mechanism for the enhancement of arbekacin resistance in a methicillin-resistant Staphylococcus aureus, FEBS LETTERS, 546(2-3), 401-406, 20030710
  107. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 89-97, 2003
  108. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, JOURNAL OF ANTIBIOTICS, 56(9), 762-767, 200309
  109. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castaneoglobisporus, PROTEIN EXPRESSION AND PURIFICATION, 34(2), 202-207, 200404
  110. Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46153-46161, 20041029
  111. Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae - Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46143-46152, 20041029
  112. Molecular cloning and expression of uricase gene from Arthrobacter globiformis in Escherichia coli and characterization of the gene product, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 98(3), 153-158, 200409
  113. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
  114. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
  115. ★, The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: Crystallographic analysis to elucidate the binding mode of the antibiotic to the protein, JOURNAL OF MOLECULAR BIOLOGY, 360(2), 398-408, 20060707
  116. ★, Purification and characterization of the second Streptomyces phospholipase A(2) refolded from an inclusion body, PROTEIN EXPRESSION AND PURIFICATION, 50(1), 82-88, 200611
  117. ★, Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
  118. ★, Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(12), 9073-9081, 20070323
  119. ★, Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(11), 2852-2855, 200711
  120. ★, Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 106(3), 303-305, 200809
  121. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
  122. Crystal structure of SCCA1 and insight about the interaction with JNK1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(1), 143-147, 20090227
  123. A novel transformation system using a bleomycin resistance marker with chemosensitizers for Aspergillus oryzae, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1), 42-47, 20090522
  124. ★, Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
  125. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
  126. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
  127. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
  128. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
  129. Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
  130. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
  131. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
  132. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
  133. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217
  134. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
  135. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 201207
  136. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
  137. Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 201304
  138. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
  139. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 201311
  140. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
  141. Structural biological study of self-resistance determinants in antibiotic-producing actinomycetes, JOURNAL OF ANTIBIOTICS, 68(9), 543-550, 201509
  142. The structural and mutational analyses of O-ureido-l-serine synthase necessary for d-cycloserine biosynthesis, FEBS JOURNAL, 282(20), 3929-3944, 201510
  143. High-Level Heterologous Production of D-Cycloserine by Escherichia coli, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(22), 7881-7887, 201511
  144. Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C Protein, JOURNAL OF VIROLOGY, 89(22), 11487-11499, 201511
  145. Characterization and Mutational Analysis of a Two-Polypeptide Bacteriocin Produced by Citrus Iyo-Derived Lactobacillus brevis 174A, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(12), 1902-1909, 201512
  146. Implementation and Evaluation of Genetic Testing Seminars on Lifestyle-related Disease Prevention for Pharmacy Students, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 136(2), 337-350, 201602
  147. Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 70(5), 582-587, 201605
  148. Oxidative and Random Cleavage of DNA by the Novel Iron(II)Complex Capable of Yielding an Iron(III)Hydroperoxide Intermediate, Chem. Lett., 1998(1), 39-40, 199801
  149. Bacillopeptins, New Cyclic Lipopeptide Antibiotics from Bacillus subtilis FR-2, J. Antibiotics, 48(10), 1095-1103, 19951025
  150. Effects of Methionine and Cu2+ on the Expression of Tyrosinase Activity in streptomyces castaneoglobisoprus, Journal of Biochemistry, 120(6), 1141-1145, 19961201
  151. Gene Technology to Overproduce the Enzymes Useful as Diagnostic Reagents, 43(8), 765-771, 19950825
  152. Purification and Characterization of a Puromycin-Hydrolyzing Enzyme from Blasticidin S-Producing Streptomyces morookaensis, Journal of Biochemistry, 123(2), 247-252, 19980201
  153. Protection of Mammalian Cells from the Toxicity of Bleomycin by Expression of a Bleomycin-Binding Protein Gene from Streptomyces verticillus, Journal of Biochemistry, 124(4), 835-841, 19981001
  154. A Mammalian Vector carrying the Bleomycin N-Acetyltransefrase Gene from Bleomycin-producing Streptomyces verticillus as a Selective Marker, J. Antibiot., 52(10), 895-899, 19991025
  155. Use of Bleomycin- and Heat Shock-Induced Calreticulin Promoter for Construction of a Mammalian Expression Vector, Journal of Biochemistry, 129(5), 671-674, 20010501
  156. Molecular Cloning of a D-Cycloserine Resistance Gene from D-Cycloserine-producing Streptomyces garyphalus, The Japanese Journal of Antibiotics, 56(9), 762-767, 2003
  157. RBE of HTO to ^<60>Co Gamma-Rays for Cell Killing of A Radioresistant E. coli Harboring Plasmid, Journal of radiation research, 32(3), 286-295, 199109
  158. Molecular Cloning and Expression of Uricase Gene from Arthrobacter globiformis in Escherichia coli and Characterization of the Gene Product(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING), Journal of bioscience and bioengineering, 98(3), 153-158, 20040925
  159. Biosynthetic Correlation between Streptomycin and Mucopeptide in Utilization of D-Glucosamine as a Common Precursor, Journal of fermentation technology, 59(2), 91-96, 19810425
  160. Binding of Streptomycin to the Teichoic Acid of Streptomycin-Producing Streptomyces griseus, Journal of fermentation technology, 60(1), 13-17, 19820225
  161. Ribosomal Resistance to Streptomycin in Strains Regenerated from Protoplasts of a Streptomycin-Susceptible Mutant Derived from a Streptomycin Producer, Journal of fermentation technology, 61(4), 347-351, 19830825
  162. Streptothricin Production by a New Isolate of Streptomyces from Thailand Soil, Journal of fermentation technology, 62(1), 19-28, 19840225
  163. Molecular Cloning and Expression of a Streptomyces Sarcosine Oxidase Gene in Streptomyces lividans, Bioscience, biotechnology, and biochemistry, 56(3), 432-436, 19920323
  164. High Level Expression of Human Transforming Growth Factor α Gene in Escherichia coli in a Fusion Gene System with Human Growth Hormone Gene, Journal of fermentation and bioengineering, 71(4), 216-220, 19910425
  165. Expression of an Artificial Gene Coding for a Human Secretin Precursor-Like Peptide in Escherichia coli, Journal of fermentation and bioengineering, 72(3), 179-182, 19910925
  166. Molecular Cloning and High Expression of the Bacillus Creatinase Gene in Escherichia coli, Journal of fermentation and bioengineering, 76(2), 77-81, 19930825
  167. Cloning, Sequencing, and Overexpression in Escherichia coli of a Sarcosine Oxidase-Encoding Gene Linked to the Bacillus Creatinase Gene, Journal of fermentation and bioengineering, 77(3), 231-234, 19940325
  168. Development of a Useful Vector System That Enables Visual Detection of Inhibitors of Nucleic Acid Synthesis, Journal of fermentation and bioengineering, 84(2), 155-157, 19970825
  169. A Convenient Method for the Evaluation of Anti-Tumor Agents Affecting the Cell Cycle, Journal of bioscience and bioengineering, 90(5), 574-576, 20001125
  170. Molecular and Structural Biology of Bleomycin and Its Resistance Determinants, Journal of bioscience and bioengineering, 93(2), 105-116, 20020225
  171. Mechanisms of resistance to antibiotics in actinomycetes., Hakkokogaku Kaishi, 69(4), 253-270, 19910725
  172. Structure and function of blmA gene of bleomycin-producing microorganism, 3, 19911010
  173. Overexpression of a Protein Induced by Bleomycin in Escherichia coli, 3, 19911010
  174. Mechanism of self-protection in a puromycin-producing microorganism, 59, 19841118
  175. Mechanism of self-protection in a streptomycin-producing microorganism, 59, 19841118
  176. Molecular cloning of a streptomycin6-kinase gene from the streptomycin-producing Streptomyces griseus, 59, 19841118
  177. Develpoment of cloning vectors which can be used in many of the antibiotic-producing microorganisms, 59, 19841118
  178. Pleiotropic Mutation in A-Factor Independent Strain of Streptomyces griseus, 60, 19851015
  179. Molecular breeding of the antibiotic-producing microorganisms by introduction of the drug resistant genes, 60, 19851015
  180. Acetylation of Blasticidin S by the producing microorganism, 60, 19851015
  181. Pleiotropic mutation in Streptomyces griseus independent of A-factor, 62, 19871102
  182. Two genes of streptomycin kinasein a streptomycin producer, 62, 19871102
  183. The Nucleotide Sequence of Streptomycin 6-kinase gene, 61, 19861117
  184. Development of a coupled transcription-translation system in Streptomyces griseus., 61, 19861117
  185. Isolation and characterization of blasticidin S acetylating enzyme in a blasticidin S producer., 61, 19861117
  186. Genetic Studies on Differentiation in a Streptomycete Strain Independent of A-factor., 61, 19861117
  187. Self-resistance mechanisms in antibiotic-proucing microorganisms, 2, 19901010
  188. Activation of the ERKs pathway prevents susceptibility to the H_2O_2-induced apoptosis in human pancreatic cancer cell line., 11, 19990816
  189. Structure and function of a gene encoding a puromycin-inactivating enzyme from Streptomyces morookaensis, 11, 19990816
  190. Structure and function of a D-cycloserine(Cs)-biosynthetic gene operon from Cs-producing Streptomyces lavendulae, 11, 19990816
  191. The 1.6Å crystal structure of Streptomyces violaceoruber phospholipase A_2 binding calcium ion., 11, 19990816
  192. Crystal struture of bleomycin-binding protein, BLMT, complexed with bleomycin, 11, 19990816
  193. Crystal structure of a novel phospholipase A_2 from Streptomyces violaceoruber, 10, 19980831
  194. Expression of a bleomycin-resistance gene blmB from Streptomyces in mammalian cells and construction of cloning vector useful in E.coli., 10, 19980831
  195. Site-directed mutagenesis study of a blomycin-binding protein, BLMA, from Streptomyces verticillus., 10, 19980831
  196. Molecular cloning and characterization of D-cycloserine resistance gene from D-cycloserine-producing microorganisms., 10, 19980831
  197. Crystal struture of bleomycin-binding protein (BLMT) from Tn5, 10, 19980831
  198. Protein engineering for human pancreatic PhospholipaseA_2., 10, 19980831
  199. Analysis of bleomycin-inducible genes in human lung fibroblast., 12, 20000710
  200. Analysis of bleomycin-inducible genes in human normal lung fibroblasts, 13, 20010824
  201. 569 Bleomycin-induced arbekacin resistance in methicillin resistant Staphylococcus aureus (MRSA), 6, 19941010
  202. Molecular cloning of a Streptomyces cholesterol esterase gene, 4, 19921010
  203. Overexpression of a protein induced by bleomycin in Eschericha coli, 4, 19921010
  204. Functional analysis of the bleomycin-resistance gene product from transposon Tn5, 9, 19970905
  205. Mechanism of high level resistance to arbekacin in methicillin-resistant Staphylococcus aureus., 9, 19970905
  206. Expression of bleomycin-resistance gene from Streptomyces in mammalian cells, 8, 19960905
  207. Purification and characterization of the puromycin-inactivating enzyme from S. morookaensis., 8, 19960905
  208. 946 Blepharismin, a photoreceptor pigment from Blepharisma enhances the antibacterial activity of arbekacin in MRSA, 8, 19960905
  209. The bleomycin-binding protein induces the expression of tac promoter controlled gene, 7, 19950915
  210. Development of an intelligent vector to screen antibiotics which inhibit the synthesis of nucleic acids, 7, 19950915
  211. Overexpression of β-lactamase induced by bleomycin in Escherichia coli, 7, 19950915
  212. Blasticidin S-producing Streptomyces morookaensis possesses a novel enzyme which hydrolyzes puromycin., 7, 19950915
  213. RESISTANCE MECHANISMS TO STREPTOMYCIN IN STREPTOMYCIN-PRODUCING STREPTOMYCES GRISEUS, Journal of pharmacobio-dynamics, 4(4), "s-45", 198104
  214. Novel Assay System Favorable for the Study of Cell-to-Cell Transmission of HIV-1 and Its Application to the Evaluation of Anti-HIV Drugs, Biological & pharmaceutical bulletin, 18(6), 920-922, 19950615
  215. Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity, Biological & pharmaceutical bulletin, 18(7), 996-1000, 19950715
  216. Molecular Cloning and Characterization of Gene Encoding Novel Puromycin-Inactivating Enzyme from Blasticidin S-Producing Streptomyces morookaensis(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING), Journal of bioscience and bioengineering, 101(1), 63-69, 20060125
  217. (244) Immune-function and Colonization on Plants of Lacto Acetic Bacteria Pediococcus pentosaceus KMC05 Selected as an Biocontrol Agent against Fusarium Wilt of Spinach(Abstract of the Paper Presented at the 2006 Annual Meeting in Sapporo), Annals of the Phytopathological Society of Japan, 72(4), 266-267, 20061125
  218. Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING), Journal of bioscience and bioengineering, 106(3), 303-305, 20080925
  219. 1G09-4 Kinetic studies of tyrosinase inhibitors contained in sake lees, 18, 20060803
  220. 1012 Analysis of the bleomycin responsive genes in the human normal lung fibroblasts, 14, 20020925
  221. 541 Survival advantage of Escherichia coli caused by a bleomycin resistance gene from Tn5, 14, 20020925
  222. 2B10-3 Cloning and characterization of a PTPase gene (ptpB) from Streptomyces lavendulae, 16, 20040825
  223. 3A10-4 Physio-chemical characterization of recombinant uricase from Arthrobacter globiformis, 16, 20040825
  224. 2A16-1 Characterization of a Streptomyces D-alanyl-D-alanine ligase as a target of D-cycloserine and as a D-cycloserine-resistance determinant, 16, 20040825
  225. 2A15-5 Structural biology of an alanine racemase from D-cycloserine-producing microorganism, 16, 20040825
  226. 1pB17-2 Cloning and functional analysis of a blue pigment biosynthetic gene from D-cycloserine-producing Streptomyces lavendulae, 16, 20040825
  227. 2H10-3 Transcriptional regulation of the secondary metabolite-encoding genes in Streptomyces lavendulae ATCC11924, 18, 20060803
  228. 2H10-2 Functional analysis of the tyrosine-phosphorylated proteins expressed in Streptomyces coelicolor A3 (2), 18, 20060803
  229. 3F11-4 The Mitomycin C (MMC)-binding Protein from MMC-producing Microorganisms Protects from the Lethal Effect of Bleomycin, 18, 20060803
  230. 1C10-2 Mutational analysis of BPSA, a single module type NRPS catalyzing indigoidine synthesis, 19, 20070802
  231. 1C10-1 A substrate-binding mode of bleomycin N-acetyltransferase, 19, 20070802
  232. 2E09-1 Sequence analysis and structural organization of four plasmids from bacteriocin-producing Lactobacillus brevis 925A, 19, 20070802
  233. 1Bp21 A proposed regulatory mechanism for the biosynthesis of a class IIb bacteriocin brevicin 174A, 21, 20090825
  234. 2Da08 Crystal structure of a Streptomyces serine O-acetyltransferase responsible for the biosynthesis of D-cycloserine, 21, 20090825
  235. 2Ma06 Molecular breeding of 2-phenylethanol-producing Lactobacillus plantarum, 21, 20090825
  236. 1P-015 Analysis of the dcsA gene responsible for N^ω-hydroxy-L-arginine formation in the biosynthesis of D-cycloserine, 65, 20130825
  237. 1P-069 Identification of the residues important for catalytic expression of O-ureido-L-serine synthase, DcsD, found in D-cycloserine biosynthetic pathway, 65, 20130825
  238. 2P-222 Identification of an enzyme catalyzing the deamino-acylation of leucylblasticidin S, 65, 20130825
  239. 1P-047 Development of a system producing highly an anti-tubercular antibiotic D-cycloserine in E. coli, 66, 20140805
  240. Improvement of constipation and liver function by plant-derived lactic acid bacteria : A double-blind, randomized trial, Nutrition, 26(4), 367-374, 201004
  241. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLoS ONE, 7(2), 2012
  242. Intracellular accumulation of trehalose during streptomycin formation by Streptomyces griseus., Bioscience, Biotechnology, and Biochemistry, 48(2), 285-290, 1984
  243. Correlation between intracellular accumulation of peptidoglycan precursors and streptomycin formation., Bioscience, Biotechnology, and Biochemistry, 48(2), 291-297, 1984
  244. In vivo cloning of arylsulfatase-tyramine oxidase genes in rec strains of Klebsiella aerogenes., Bioscience, Biotechnology, and Biochemistry, 47(8), 1807-1815, 1983
  245. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, Journal of Pharmacobio-Dynamics, 33(2), 289-293, 2010
  246. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, Journal of Pharmacobio-Dynamics, 33(10), 1673-1679, 2010
  247. Bacillopeptins, New Cyclic Lipopeptide Antibiotics from Bacillus subtilis FR-2., The Japanese Journal of Antibiotics, 48(10), 1095-1103, 1995
  248. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain., The Japanese Journal of Antibiotics, 34(9), 1183-1188, 1981
  249. Effect of arginine on gramicidin S biosynthesis by Bacillus brevis., The Japanese Journal of Antibiotics, 35(5), 615-621, 1982
  250. Isolation and properties of a puromycin acetyltransferase from puromycin-producing Streptomyces alboniger., The Japanese Journal of Antibiotics, 38(12), 1761-1766, 1985
  251. Acetylation of blasticidin S by its producing actinomycetes., The Japanese Journal of Antibiotics, 39(6), 827-832, 1986
  252. Isolation and properties of a blasticidin S acetylating enzyme from a producer organism., The Japanese Journal of Antibiotics, 42(1), 135-137, 1989
  253. Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content., Actinomycetologica, 16(2), 17-20, 2002
  254. Streptomycin biosynthesis and self-resistance mechanism in streptomycin-producing Streptomyces griseus., Actinomycetologica, 4(1), 15-22, 1990
  255. Oral lactic acid bacteria related to the occurrence and/or progression of dental caries in Japanese preschool children, Bioscience and Microflora, 0(0), 29-36, 2015
  256. Mechanism of Protection of Protein Synthesis Against Streptomycin Inhibition in a Producing Strain, Journal of Antibiotics, 34(9), p1183-1188, 198109
  257. Crystallographic and mutational analyses of cystathionine beta-synthase in the H2S-synthetic gene cluster in Lactobacillus plantarum, PROTEIN SCIENCE, 26(4), 763-783, 201704
  258. Characterization of Exopolysaccharides Produced by Thermophilic Lactic Acid Bacteria Isolated from Tropical Fruits of Thailand, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(5), 621-629, 201705
  259. Activation Mechanism of the Streptomyces Tyrosinase Assisted by the Caddie Protein, BIOCHEMISTRY, 56(41), 5593-5603, 20171017
  260. Implementation and Evaluation of Genetic Testing Seminars about Lifestyle-related Disease Prevention in Pharmacy Insurance -The Need for Cooperation between the Pharmacy and the University in Genetic Testing-, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 137(12), 1517-1531, 201712
  261. Expression of Genes Involved in Bacteriocin Production and Self-Resistance in Lactobacillus brevis 174A Is Mediated by Two Regulatory Proteins, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 84(7), 201804
  262. Characterization of the SN35N Strain-Specific Exopolysaccharide Encoded in the Whole Circular Genome of a Plant-Derived &ITLactobacillus&IT &ITplantarum&IT, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41(4), 536-545, 201804
  263. A novel structure of exopolysaccharide produced by a plant-derived lactic acid bacterium Lactobacillus paracasei IJH-SONE68, JOURNAL OF BIOCHEMISTRY, 164(2), 87-92, 201808
  264. Catalytic mechanism of the tyrosinase reaction toward the Tyr(98) residue in the caddie protein, PLOS BIOLOGY, 16(12), 201812
  265. Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Improves the Picryl Chloride-Induced Contact Dermatitis, MOLECULES, 24(16), 201908
  266. Development of a System of High Ornithine and Citrulline Production by a Plant-Derived Lactic Acid Bacterium, Weissella confusa K-28, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 42(9), 1581-1589, 201909
  267. Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human, JOURNAL OF ANTIBIOTICS, 72(11), 834-842, 201911
  268. Improvement of Alcohol-Poisoning Symptoms in Mice by the Oral Administration of Live Lactobacillus plantarum SN13T Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(5), 202003
  269. Interleukin-8 Release Inhibitors Generated by Fermentation ofArtemisia princepsPampanini Herb Extract WithLactobacillus plantarumSN13T, FRONTIERS IN MICROBIOLOGY, 11, 20200603
  270. Cyclization mechanism catalyzed by an ATP-grasp enzyme essential for d-cycloserine biosynthesis, FEBS JOURNAL, 287(13), 2763-2778, 202007
  271. Catalytic specificity of the Lactobacillus plantarum cystathionine gamma-lyase presumed by the crystallographic analysis, SCIENTIFIC REPORTS, 10(1), 20200910
  272. Molecular cloning and characterization of gene encoding novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 101(1), 63-69, 200601
  273. Heme Protein and Hydroxyarginase Necessary for Biosynthesis of D-Cycloserine, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 56(7), 3682-3689, 201207
  274. ★, A novel transformation system using a bleomycin resistance marker with chemosensitizers for Aspergillus oryzae, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 383(1), 42-47, 20090522
  275. Crystal structure of SCCA1 and insight about the interaction with JNK1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 380(1), 143-147, 20090227
  276. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
  277. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
  278. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(11), 2852-2855, 200711
  279. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 201311
  280. Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
  281. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
  282. Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
  283. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
  284. Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 201304
  285. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
  286. Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
  287. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
  288. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
  289. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
  290. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
  291. Purification and characterization of the second Streptomyces phospholipase A(2) refolded from an inclusion body, PROTEIN EXPRESSION AND PURIFICATION, 50(1), 82-88, 200611
  292. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
  293. The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: Crystallographic analysis to elucidate the binding mode of the antibiotic to the protein, JOURNAL OF MOLECULAR BIOLOGY, 360(2), 398-408, 20060707
  294. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
  295. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
  296. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
  297. Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 106(3), 303-305, 200809
  298. Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(12), 9073-9081, 20070323
  299. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
  300. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217

Publications such as books

  1. 1994/12/14, Antibiotics produced by ┣DBStreptomyces(/)-┫DB host-vector systems. , In Recombinant Microbes for industrial and agricultural applications, marcel dekker= inc., 1994, 12, Scholarly Book, Joint work, en, 896
  2. 2012/09, Advanced Technology for Microbiological Production in Japan, 微生物の物質資産について,その技術,応用の最新の状況, 2012, 10, Scholarly Book, Joint work, jp, ISBN-10:4781306586,ISBN-13:978-4781306582, 223, p186-193
  3. 2014, Microbiol Production , From Genome Design to Cell Engineering Structure of Tyrosinase and Its Inhibitor from Sake Lees, Springer, 2014, Scholarly Book, Joint work, en, Anazawa, H. ; Shimizu, S. (Eds.) , 978-4-431-54606-1, 306, pp.243-249

Awards

  1. 2011/09/04, The 14th John M. Kinney Award for General Nutrition, The Nutritional Sciences,Education & Research Fund (NSERF) と国際栄養科学雑誌「Nutrition」との連名, 植物乳酸菌が便秘と肝機能の改善に優れていることのヒト臨床試験による実証

Patented

  1. Patent, TW:I727293, 2021/05/11, COMPOSITION FOR TYPE IV ALLERGY
  2. Patent, CA:3086031, 2021/11/23, COMPOSITION FOR TYPE IV ALLERGY
  3. Patent, AU:2019260953, 2021/05/06, COMPOSITION FOR TYPE IV ALLERGY
  4. Patent, KR:10-2368628, 2022/02/23, COMPOSITION FOR TYPE IV ALLERGY
  5. Patent, EP:3714701, 2022/08/10, COMPOSITION FOR TYPE IV ALLERGY
  6. Patent, 6679202, 2020/03/23, COMPOSITION FOR TYPE IV ALLERGY
  7. Patent, TW:I739078, 2021/09/11, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  8. Patent, CA:3086024, 2022/02/08, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  9. Patent, AU:2019260952, 2021/02/25, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  10. Patent, KR:10-2368627, 2022/02/23, COMPOSITION FOR SUPPRESSING FAT ACCUMULATION
  11. Patent, 6649539, 2020/01/21, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  12. Patent, TW:I746955, 2021/11/21, COMPOSITION FOR TYPE I ALLERGY
  13. Patent, CA:3085995, 2022/03/08, COMPOSITION FOR TYPE I ALLERGY
  14. Patent, AU:2019260951, 2021/03/25, COMPOSITION FOR TYPE I ALLERGY
  15. Patent, KR:10-2368626, 2022/02/23, COMPOSITION FOR TYPE I ALLERGY
  16. Patent, 6648348, 2020/01/17, COMPOSITION FOR TYPE I ALLERGY
  17. Patent, TW:I713850, 2020/12/21, Nobel lactic acid bacteria and use thereof
  18. Patent, NZ:750198, 2022/10/04, Nobel lactic acid bacteria and use thereof
  19. Patent, CA:3032579, 2020/06/16, Nobel lactic acid bacteria and use thereof
  20. Patent, AU:2018281512, 2020/07/09, Nobel lactic acid bacteria and use thereof
  21. Patent, KR:10-2361556, 2022/02/07, Nobel lactic acid bacteria and use thereof
  22. Patent, 6523579, 2019/05/10, Nobel lactic acid bacteria and use thereof
  23. Patent, TW:I696465, 2020/06/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  24. Patent, NZ: 750188, 2022/08/02, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  25. Patent, CA:3032572, 2020/04/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  26. Patent, AU:2018281511, 2020/07/30, NEW LACTIC ACID BACTERIUM AND THEREOF
  27. Patent, KR:10-2313677, 2021/10/12, NEW LACTIC ACID BACTERUM AND USE THEREOF
  28. Patent, US:11447740, 2022/09/20, NEW LACTIC ACID BACTERUM AND USE THEREOF

Social Activities

Organizing Academic Conferences, etc.

  1. Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/03, 2009/03
  2. The 2nd International Symposium for Lactic Acid Bacteria to Prevented to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/12, 2009/12
  3. The 3rd International Symposium for Lactic Acid Bacteria to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2010/12, 2010/12
  4. The 4th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2011/12, 2011/12
  5. The 5th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2012/12, 2012/12
  6. The 2013 Annual Meeting of the Society for Actinomycetes Japan Abstracts, 2013/09, 2013/09
  7. The 6th International Symposium for Probiotics to preventive & Pre-symptomatic Medicine, Representative, 2014/03, 2014/03
  8. 2014 Annual Meeting of The Japan Society for Lactic Acid Bacteria, 2014/07, 2014/07