MASANORI SUGIYAMA

Last Updated :2026/08/21

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor (Collaborative Research Lab)
Web Site
http://en.hiroshima-u.jp/bhs/research/lab/other/Probiotic_Science_for_Preventive_Medicine
E-mail
sugihiroshima-u.ac.jp
Other Contact Details
1-2-3, Kasumi, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5280 FAX : (+81)82-257-5284
Self-introduction
I (Professor Sugiyama) have studied on the self-resistance mechanisms in antibiotic-producing actinomyces during 40 years. My boss, who had employed me as a assistant professor, has always encouraged me at the following phrase: "If you will continue the study for 10 years, you will be an expert at the microbiology field. Furthermore, if you will continue the study as your lifework, you will become an authority at the scientific field.

Basic Information

Major Professional Backgrounds

  • 1987/05/01, Institute Pasteur Paris, Microbiolgy Unit, Researcher
  • 1992/04/01, Hiroshima University, Faculty of Medicine, Professor

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Engineering, Japan, 1974/04, 1976/03
  • Hiroshima University, Faculty of Engineering, Japan, 1971/04, 1974/03

Academic Degrees

  • Doctor of Engineering, Hiroshima University
  • Master of Engineering, Hiroshima University

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Natural medicines

Research Keywords

  • X-ray crystallography
  • three dimensional analysis of protein by X-ray
  • actinomycetes
  • plant-derived lactic acid bacteria
  • molecular microbiology
  • gene regulation sciences
  • antibiotics
  • probiotics
  • secondary metabolite

Affiliated Academic Societies

  • The Society for Biotechnology,Japan
  • The Phamaceutical Society of Japan
  • Japanese Society for Bachteriology
  • The Society for Actinomycetes Japan
  • Japan Society for Lactic Acid Bacteria
  • ASBMB　(The American Society for Biochemistry and Molecular Biology)
  • Japan Bioindustiry Association

Educational Activity

Course in Charge

  1. 2026, Graduate Education (Master's Program) , First Semester, Seminar on Probiotic Science for Preventive Medicine
  2. 2026, Graduate Education (Master's Program) , Second Semester, Seminar on Probiotic Science for Preventive Medicine
  3. 2026, Graduate Education (Master's Program) , First Semester, Research on Probiotic Science for Preventive Medicine
  4. 2026, Graduate Education (Master's Program) , Second Semester, Research on Probiotic Science for Preventive Medicine
  5. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  6. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Probiotic Science for Preventive Medicine
  7. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Probiotic Science for Preventive Medicine
  8. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Probiotic Science for Preventive Medicine

Award of Education

  1. 2025/08/27
  2. 2014/11/03

Research Activities

Academic Papers

  1. Effects of Lactiplantibacillus plantarum A458 on Lactose Intolerance in Mice: Associations with Gut Microbiota and Redox Balance, MICROORGANISMS, 14(6), 20260605
    Link to Paper Search Results by DOI
  2. Fermentation-Derived 6-Shogaol from Zingiber officinale Rhizome Extract Inhibits Periodontal Biofilm Formation via Modulation of Quorum Sensing-Related Gene Expression, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 27(13), 20260726
    Link to Paper Search Results by DOI
  3. Anti-Tumor Activity of Stevia Leaf Extract Fermented by the Plant-Derived Lactiplantibacillus plantarum SN13T in a Pancreatic Tumor Xenograft Model, ANTIOXIDANTS, 15(5), 20260504
    Link to Paper Search Results by DOI
  4. Effect of probiotic Limosilactobacillus reuteri on a serum sex-hormone- and metabolic-syndrome-related health evaluation: a single-arm open-label pilot study, BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH, 45(1), 42-50, 2026
    Link to Paper Search Results by DOI
  5. Integrator Complex Subunit 6 Regulates Biological Nature of Hepatocellular Carcinoma by Modulating Epithelial-Mesenchymal Transition, Curr Issues Mol Biol, 47(733), 20250909
    Link to Paper Search Results by DOI
  6. Integrator Complex Subunit 6 Regulates Biological Nature of Hepatocellular Carcinoma by Modulating Epithelial-Mesenchymal Transition, CURRENT ISSUES IN MOLECULAR BIOLOGY, 47(9), 20250909
    Link to Paper Search Results by DOI
  7. Strategic approach of disease-prevention based upon variability of intestinal microbiota and biological impact induced by ingested sour-bread baked with plant-derived lactic acid bacteria in mice, 106, 31-40, 2024
  8. Non-pathogenic Heyndrickxia coagulans (Bacillus coagulans) 29-2E inhibits the virulence of pathogenic Salmonella Typhimurium by quorum-sensing regulation, J Biosci Bioeng, 137, 445-452, 202403
    Link to Paper Search Results by DOI
  9. Stevia Leaf Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T Displays Anticancer Activity to Pancreatic Cancer PANC-1 Cell Line, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26(9), 20250428
    Link to Paper Search Results by DOI
  10. Atractylodes Japonica Rhizome Extract Fermented with a Plant-Derived Lacticaseibacillus paracasei (Lactobacillus paracasei) IJH-SONE68 Improves the Wheat Gliadin-Induced Food Allergic Reaction in Mice, NUTRIENTS, 17(7), 20250326
    Link to Paper Search Results by DOI
  11. Eriobotrya japonica Fermentation with Plant-Derived Lactiplantibacillus plantarum MSC-5T Ameliorates Antioxidant Activity in HEK293 Cells,, 10(4), 202404
  12. Role of Phenolic Acid Metabolism in Enhancing Bioactivity of Mentha Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T, 16(3), 1052-1064, 202406
  13. Characterization of the Gamma-Aminobutyric Acid (GABA) Biosynthetic Gene Cluster in High GABA-Producing Enterococcus avium G-15, FERMENTATION-BASEL, 10(8), 202408
    Link to Paper Search Results by DOI
  14. Non-pathogenic Heyndrickxia coagulans (Bacillus coagulans) 29-2E inhibits the virulence of pathogenic Salmonella Typhimurium by quorum-sensing regulation, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 137(6), 445-452, 202406
    Link to Paper Search Results by DOI
  15. Silk-derived sericin/fibroin mixture drink fermented with plant-derived Lactococcus lactis BM32-1 improves constipation and related microbiota: a randomized, double-blind, and placebo-controlled clinical trial, BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH, 43(3), 282-292, 2024
    Link to Paper Search Results by DOI
  16. Eriobotrya japonica Fermentation with Plant-Derived Lactiplantibacillus plantarum MSC-5T Ameliorates Antioxidant Activity in HEK293 Cells, FERMENTATION-BASEL, 10(4), 202404
    Link to Paper Search Results by DOI
  17. Skin Anti-Aging Efficacy of a Lactobacillus plantarum GT-17F Fermented Dendrobium officinale Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study, COSMETICS, 11(1), 202402
    Link to Paper Search Results by DOI
  18. Transcriptional profiling of geniposide bioconversion into genipin during gardenia fructus extract fermentation by Lactobacillus (Lactiplantibacillus) plantarum SN13T, BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH, 43(2), 120-127, 2024
    Link to Paper Search Results by DOI
  19. Transcriptional profiling of geniposide bioconversion into genipin during gardenia fructus extract fermentation by Lactobacillus (Lactiplantibacillus) plantarum SN13T, Biosci Microbiota Food Health, 2023
  20. Dendrobium officinale extract fermented with Lactobacillus plantarum GT-17F enhances the protection of UV-mediated photoaging, Biol Pharm Bull, 46, 1451-1460, 2023
  21. Construction of a temperature-sensitive shuttle vector between lactic acid bacteria and Escherichia coli and its application to a Tn10-based random mutagenesis tool in lactic acid bacteria, Biol Pharm Bull, 46, 840-847, 2023
    Link to Paper Search Results by DOI
  22. Fermented stevia improves alcohol poisoning symptoms associated with changes in mouse gut microbiota, Nutrients, 15(3708), 20230824
  23. Role of phenolic acid metabolism in enhancing bioactivity of mentha extract fermented with plant-derived Lactobacillus plantarum SN13T, Probiotics Antimicrob Proteins, 16(3), 1052-1064, 202306
  24. Dendrobium officinale Extract Fermented with Lactobacillus plantarum GT-17F Enhances the Protection of UV-Mediated Photoaging, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46(10), 1451-1460, 202310
  25. Construction of a Temperature-Sensitive Shuttle Vector between Lactic Acid Bacteria and Escherichia coli and Its Application to a Tn10-Based Random Mutagenesis Tool in Lactic Acid Bacteria, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 46(6), 840-847, 202306
  26. Applications of Plant-Derived Lactic Acid Bacteria to Develop the Functional Foods Useful for Physical and Mental Health, 52(4), 20-28, 20230415
  27. Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves the Gut Microbiota Associated with Hepatic Disorders: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial, NUTRIENTS, 14(21), 202211
    Link to Paper Search Results by DOI
  28. 3-Phenyllactic acid generated in medicinal plant extracts fermented with plant-derived lactic acid bacteria inhibits the biofilm synthesis of Aggregatibacter actinomycetemcomitans, FRONTIERS IN MICROBIOLOGY, 13, 20220923
    Link to Paper Search Results by DOI
  29. Awareness Survey on Genetic Testing among Pharmacists in Hiroshima City, JAPANESE JOURNAL OF SOCIAL PHARMACY, Vol 41(No,1), 56-68, 2022
  30. Fermentation in Pineapple Juice Significantly Enhances Ornithine and Citrulline Production in Lactococcus lactis MSC-3G Isolated from Sugarcane, MICROORGANISMS, 10(5), 202205
    Link to Paper Search Results by DOI
  31. Exopolysaccharide Produced by Plant-Derived Lactobacillus plantarum SN35N Exhibits Antiviral Activity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 44(12), 1886-1890, 202112
    Link to Paper Search Results by DOI
  32. Biomedical applications of L-alanine produced by Pediococcus acidilactici BD16 (alaD(+)), APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 106(4), 1435-1446, 202202
    Link to Paper Search Results by DOI
  33. A novel prokaryotic phospholipase A(2) - Characterization, gene cloning, and solution structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20051-20058, 20020531
    Link to Paper Search Results by DOI
  34. Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1778(1), 33-41, 200801
    Link to Paper Search Results by DOI
  35. Susceptibility of protein synthesis to streptomycin in streptomycin-producing ., FEBS Letters, 250-252, 19800401
  36. Assessment of competitive action of streptomycin 6-kinase and streptomycin 6-phosphatase in the in vitro protein synthesis of a streptomycin-producing microorganism., FEBS Letters, 331-333, 19820401
  37. Molecular cloning and expression in of a streptomycin 6-phosphotransferase gene from a streptomycin-producing microorganism., FEBS Letters, 385-389, 19850401
  38. Susceptibility of protein synthesis to neomycin in neomycin-producing ., Journal of General Microbiology(U. K. )=, 477-478, 19800401
  39. Purification and characterization of streptomycin 6-kinase, an enzyme implicated in self-protection of a streptomycin producing microorganism., Journal of General Microbiology(U. K. )=, 1683-1687, 19830401
  40. Mechanism of self-protection in a puromycin-producing microorganism., Journal of General Microbiology(U. K. )=, 1999-2005, 19850401
  41. The nucleotide sequence of a streptomycin 6-phosphotransferase gene from a streptomycin producer., Journal of General Microbiology(U. K. )=, 1289-1296, 19870401
  42. Use of the tyrosinase gene from to probe promoter sequences for ., Plasmid(U. S. A), 237-241, 19900401
  43. Plasmid involvement in the degradation of polycyclic aromatic hydrocarbons by a Beijerinckia species., Biochemical and Biophysical Research Communications, 939-945, 19830401
  44. Biosynthetic correlation between streptomycin and mucopeptide in utilization of D-glucosamine as a common precursor., Journal of Fermentation Technology, 91-96, 19810401
  45. Binding of streptomycin to the teichoic acid of streptomycin-producing ., Journal of Fermentation Technology, 13-17, 19820401
  46. Ribosomal resistance to streptomycin in strains regenerated from protoplasts of a streptomycin-susceptible mutant derived from a streptomycin producer., Journal of Fermentation Technology, 347-351, 19830401
  47. Streptothricin production by a new isolate of from Thailand soil., Journal of Fermentation Technology, 19-28, 19840401
  48. In vivo cloning of arylsulfatase-tyramine oxidase genes in rec strains of ., Agricultural and Biological Chemistry, 1807-1815, 19830401
  49. Intracellular accumulation of trehalose during streptomycin formation by ., Agricultural and Biological Chemistry, 285-290, 19840401
  50. Correlation between intracellular accumulation of peptideglycan precursors and streptomycin formation., Agricultural and Biological Chemistry, 291-297, 19840401
  51. Molecular cloning and expression of a sarcosine oxidase gene in ., Bioscience= Biotechnology and Biochemistry, 432-436, 19920401
  52. Mechanism of protection of protein synthesis against streptomycin inhibition in a producing strain., Journal of Antibiotics, 1183-1188, 19810401
  53. Effect of arginine of gramicidin S biosynthesis by< Bacillus>., Journal of Antibiotics, 615-621, 19820401
  54. Isolation and properties of a puromycin acetyltransferase from puromycin-producing ., Journal of Antibiotics, 1761-1766, 19850401
  55. Acetylation of blasticidin S by its producing actinomycetes., Journal of Antibiotics, 827-832, 19860401
  56. Isolation and properties of a blasticidin S acetylating enzyme from a producer organism., Journal of Antibiotics, 135-137, 19890401
  57. The primary structure of an acidic ribosomal protein from ., Biochimica et Biophysica Acta, 164-172, 19820401
  58. Fate of streptomycin in mycelium of the producer organism., Biotechnology Letters(U. K. ), 239-244, 19810401
  59. Roles of streptomycin 6-kinase and ribosomal affinity to streptomycin in self-protection of streptomycin producer., Biotechnology Letters(U. K. ), 357-362, 19810401
  60. Mechanism of resistance to streptothricin of a producing microorganism., Biotechnology Letters(U. K. ), 441-446, 19830401
  61. Protoplast formation and the regeneration of ATCC9999 and its mutants., Biotechnology Letters(U. K. ), 709-714, 19830401
  62. Overproduction of human insulin-like growth factor-(]G0002[) in ., Biotechnology Letters(U. K. ), 839-844, 19890401
  63. Kinetic studies of streptomycin uptake implicated in selfresistance in a streptomycin producer., Biotechnology Letters(U. K. ), 1-6, 19900401
  64. Silence of streptomycin 6-phosphotransferase gene derived by incubation at a high temperature in ., Biotechnology Letters(U. K. ), 537-542, 19910401
  65. Efficient purification and analysis for stability of human secretin precursor-like peptide produced in ., Biotechnology Letters(U. K. ), 603-608, 19910401
  66. Expression of an artificial gene coding for a human secretin precursor-like peptide in ., Journal of Fermentation and Bioengineering, 179-182, 19910401
  67. Two genes for streptomycin phosphotransferase in ., 353-358, 19880401
  68. Isolation and properties of the axopodial cytoskelton of a heliozoan, ., European Journal of Ptotistology, 214-219, 19920401
  69. Electrophoretic migration of the heliozoan, ., Cytobios(U. K. ), 107-114, 19840401
  70. Streptomycin biosynthesis and self-resistance mechanism in streptomycin-producing ., Actinomycetol., 15-22, 19900401
  71. Resistant mechanism to blasticidin S in ., Korean Biochemical Journal, 327-330, 19910401
  72. Mechanism of self-protection and genes coding for antibiotic biosynthesis , particularly, in microorganisms which produce antibiotic inhibitors of protein synthesis., J. Kor. Agric. Chem. Soc., 371-375, 19880401
  73. Ultrastructure and calcium-dependent contraction of the myonemal network in a heterotrich ciliate, ., European Journal of Ptotistology, 279-287, 19920401
  74. Structure and function of the cytoskeleton in Heliozoa : 2. Measurement of the force of rapid axopodial contraction in Echinosphaerium., European Journal of Ptotistology, 430-433, 19920401
  75. Molecular cloning and high expression of the creatinase gene in ., Journal of Fermentation and Bioengineering, 77-82, 19930401
  76. Susceptibility of methicillin-resistant clinical isolates to various antimicrobial agents. III. Novel. inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima Journal of Medical Sciences, 101-107, 19930401
  77. Cloning, sequencing, and overexpression in of a sarcosine oxidase-encoding gene linked to the creatinase gene., Journal of Fermentation and Bioengineering, 231-234, 19940401
  78. Expression of c-kit ligand in human keratinocytes., Arch Dermatol Res., 273-277, 19940401
  79. Inactivation of bleomycin by an N-acetyltransferase in the bleomycin-producing strain Streptomyces verticillus, FEMS Microbiology Letters, 121, 81-86, 19940401
  80. Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin, Gene, 11-16, 19940401
  81. Uracil-targeted inhibition of poly(A)-poly(U) hybridization by a zinc(II)-cyclen complex., Chem. Commun., 1747-1748, 19940401
  82. Overproduction of the bleomycin-binding proteins from bleomycin-producing Streptomyces verticillus and a methicillin-resistant Staphylococcus aureus in Escherichia coli andtheir immunological characterisation, FEBS Lett, 80-84, 19950401
  83. Novel assay system favorable for the study of cell-to-cell transmission of HIV-1 and its application to the evaluation of anti-HIV drugs., Biological and Pharmaceutical Bulletin, 18, 920-922, 19950401
  84. Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity., Biological and Pharmaceutical Bulletin, 18, 996-1000, 19950401
  85. Dimeric macrocyclic polyamines with potent inhibitory activity against human immunodeficiency virus., Antiviral Chemistry and Chemotherapy, 6, 337-344, 19950401
  86. The photoreceptor pigment of the unicellular organism Blepharisma generates hydroxyl radicals., Journal of Photochemistry and Photobiology, B:Biology34, 29-33, 19960401
  87. Expression of multiple forms of fetal liver kinase-2 (flk-2/flk-3) ligand in cultured human keratinocytes., Arch Dermatol Res., 289, 177-179, 19970401
  88. Development of a useful vector system that enables visual detection of inhibitor of nucleic acid synthesis, J. Ferment. Bioeng., 84, 155-157, 19970401
  89. Blepharismin produced by a protozoan Blepharisma functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus, FEMS Microbiol. Lett., 155(67), 71, 19970401
  90. Oxidative and random cleavage of DNA by the novel iron(II)complex capable of yielding an iron(III)hydroperoxide intermediate., Chem. Lett., 39-40, 19980401
  91. Protection of mammalian cells from the toxicity of bleomycin by expression of a bleomycin-binding protein gene from Streptomyces verticillus, J. Biochem., 124, 835-841, 19980401
  92. Characterization of the bleomycin resistance determinant ercoded on the Tn5, FEBS Lett, 442, 34-38, 19990401
  93. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5., Acta Cryst. Sec., D55, 1095-1097, 19990401
  94. Mutation of the N-terminal Proline 9 of BLMA from Streptomyces verticillus abolishes the binding affinity for bleomycin, FEBS Lett, 450, 227-230, 19990401
  95. Synthesis, Spectroscopic, Redox Properties, and DNA cleavage Activity of Low-spin Iron((]G0003[))complexes of Bleomycin Analogues., Inorgania Chimica Acta, 294, 56-61, 19990401
  96. Growth of human pancreatic cancer cells, induced by human pancreatic phospholipase A2, is mediated via its specific receptor but not via its catalytic property, INTERNATIONAL JOURNAL OF ONCOLOGY, 9, 1219-1225, 19961201
  97. Human pancreatic phospholipase A2 stimulates the growth of human pancreatic cancer cell line, FEBS Letters, 373, 85-87, 19951001
  98. Gene technology to overproduce the enzymes useful as diagnostic reagents, 43(8), 765-771, 19950801
  99. Ultrastracture and rapid axopodial contraction of a heliozoa, Raphidiophrys contractilis sp. nov., Journal of Eukaryotic Microbiology, 42(3), 283-288, 19950501
  100. Susceptibility of Methicillin-resistant Staphylococcus aureus clinical isolates to various antimicrobial agents. III. Novel, inducible resistance to macrolide-lincosamide-streptogramin B(MLS) antibiotics, Hiroshima J. Med. Sci., 42, 101-107, 19930101
  101. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1., J. Basic Microbiol., 42, 190-200, 20020401
  102. Streptomyces Phospholipase A2: Its Use in the Enzymatic Measurement of Calcium(II) Ion Content, Actinomycetologica, 16(2), 17-20, 20020401
  103. Atomic resolution structure of the prokaryotic phospholopase A2: Molecular motion and implication for catalytic mechanism., PROTEINS: Structure= Function= and Genetics, 51(3), 453-469, 20030501
  104. Molecular and structural biology of bleomycin and its resistance determinants., J. Bioscience and Bioengineering, 93, 105-116, 20020401
  105. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, J. Antibiotics, 56, 762-767, 20030401
  106. Physical stress by magnetic force accelerates differentiation of human osteoblasts, Biochem. Biophys. Res. Common, 32-38, 20030401
  107. Molecular cloning and expression of uricase gene from Arthrobactor globiformis in Escherichia coli and characterization of the gene product, J. Biosc. Bioeng.=, 153-158, 20040401
  108. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castanepglobisporus, Protein Expr Purif, 34, 202-207, 20040401
  109. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, Bioscience, Biotechnology, and Biochemistry, 71(11), 2852-2855, 20071101
  110. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat., In Vitro Cell Dev Biol Anim, 39(1-2), 89-97, 20030101
  111. A novel assay method for an amino acid racemase reaction based on circular dichroism, Biochem. J., 389, 491-496, 20050701
  112. Self-protection mechanisms of antibiotic-producing microorganisms, Nippon rinsyo, 65, 669-673, 20070228
  113. Crystallization and preliminary X-ray diffraction studies of bleomycin-binding protein encoded on the transposon Tn5, Acta Crystallogr. Sect. D, 55, 1095-1097, 19990501
  114. A mammalian vector carrying the bleomycin N-acetyltransferase gene from Streptomyces verticillus as a selective marker, J. Antibiot., 52, 895-899, 19990401
  115. Molecular and structural biology of bleomycin and its resistance determinants, J. Biosci. Bioeng., 93, 105-116, 20020401
  116. Effects of methionine and Cu2+ on the expression of tyrosinase activity in Streptomyces castaneoglobisporus., J. Biochem., 120(6), 1141-1145, 19961201
  117. Molecular cloning and characterization of a gene encoding a novel puromycin-inactivating enzyme from blasticidin S-producing Streptomyces morookaensis., J. Biosci. Bioeng., 101(1), 63-69, 20061101
  118. Establishment of an in vitro Peyer's patch cell culture system correlative to in vivo study using intestine and screening of lactic acid bacteria enhancing intestinal immunity., Biol. Pharm. Bull., 33(2), 289-293, 20100201
  119. ★, Crystal structure of SCCA1 and insight about the interaction with JNK1., Biochem. Biophys. Res. Commun., 380(1), 143-147, 20090201
  120. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im., Biochem. Biophys. Res. Commun., 378(3), 574-548, 20090101
  121. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS: Structure= Function= and Genetics, 79(10), 2999-3005, 20110901
  122. Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line., FEBS Letters, 407, 343-346, 19970501
  123. The 1.5 angstrom crystal structure of a bleomycin resistance determinant from bleomycin-producing Streptomyces verticillus, JOURNAL OF MOLECULAR BIOLOGY, 295(4), 915-925, 20000128
    Link to Paper Search Results by DOI
  124. A novel approach to gene therapy of albino hair in histoculture with a retroviral Streptomyces tyrosinase gene, PIGMENT CELL RESEARCH, 13(5), 345-351, 200010
    Link to Paper Search Results by DOI
  125. A convenient method for the evaluation of anti-tumor agents affecting the cell cycle, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 90(5), 574-576, 200011
    Link to Paper Search Results by DOI
  126. Crystallization and preliminary X-ray diffraction studies of Streptomyces phospholipase A(2) in a calcium-binding form, JOURNAL OF INORGANIC BIOCHEMISTRY, 82(1-4), 221-223, 200011
    Link to Paper Search Results by DOI
  127. Use of bleomycin- and heat shock-induced calreticulin promoter for construction of a mammalian expression vector, JOURNAL OF BIOCHEMISTRY, 129(5), 671-674, 200105
    Link to Paper Search Results by DOI
  128. Crystal structures of the transposon Tn5-carried bleomycin resistance determinant uncomplexed and complexed with bleomycin, JOURNAL OF BIOLOGICAL CHEMISTRY, 276(13), 9992-9999, 20010330
    Link to Paper Search Results by DOI
  129. The 1.6-A crystal structure of the copper(II)-bound bleomycin complexed with the bleomycin-binding protein from bleomycin-producing Streptomyces verticillus, JOURNAL OF BIOLOGICAL CHEMISTRY, 277(3), 2311-2320, 20020118
    Link to Paper Search Results by DOI
  130. Molecular and structural biology of bleomycin and its resistance determinants, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 93(2), 105-116, 200202
    Link to Paper Search Results by DOI
  131. The crystal structure of prokaryotic phospholipase A(2), JOURNAL OF BIOLOGICAL CHEMISTRY, 277(22), 20059-20069, 20020531
    Link to Paper Search Results by DOI
  132. Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1, JOURNAL OF BASIC MICROBIOLOGY, 42(3), 190-200, 2002
    Link to Paper Search Results by DOI
  133. Physical stress by magnetic force accelerates differentiation of human osteoblasts, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 311(1), 32-38, 20031107
    Link to Paper Search Results by DOI
  134. Atomic resolution structure of prokaryotic phospholipase A(2): Analysis of internal motion and implication for a catalytic mechanism, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 51(3), 453-469, 20030515
    Link to Paper Search Results by DOI
  135. Molecular mechanism for the enhancement of arbekacin resistance in a methicillin-resistant Staphylococcus aureus, FEBS LETTERS, 546(2-3), 401-406, 20030710
    Link to Paper Search Results by DOI
  136. Cell differentiation and p38(MAPK) cascade are inhibited in human osteoblasts cultured in a three-dimensional clinostat, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 39(1-2), 89-97, 2003
    Link to Paper Search Results by DOI
  137. Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus, JOURNAL OF ANTIBIOTICS, 56(9), 762-767, 200309
    Link to Paper Search Results by DOI
  138. An efficient method for the overexpression and purification of active tyrosinase from Streptomyces castaneoglobisporus, PROTEIN EXPRESSION AND PURIFICATION, 34(2), 202-207, 200404
    Link to Paper Search Results by DOI
  139. Structural evidence that alanine racemase from a D-cycloserine-producing microorganism exhibits resistance to its own product, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46153-46161, 20041029
    Link to Paper Search Results by DOI
  140. Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae - Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine, JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 46143-46152, 20041029
    Link to Paper Search Results by DOI
  141. Molecular cloning and expression of uricase gene from Arthrobacter globiformis in Escherichia coli and characterization of the gene product, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 98(3), 153-158, 200409
    Link to Paper Search Results by DOI
  142. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
    Link to Paper Search Results by DOI
  143. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
    Link to Paper Search Results by DOI
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  311. Effects of Citrus unshiu powder on the cytokine balance in peripheral blood mononuclear cells of patients with seasonal allergic rhinitis to pollen, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71(11), 2852-2855, 200711
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  312. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 201311
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  313. Characterization of four plasmids harboured in a Lactobacillus brevis strain encoding a novel bacteriocin, brevicin 925A, and construction of a shuttle vector for lactic acid bacteria and Escherichia coli, MICROBIOLOGY-SGM, 155, 1726-1737, 200905
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  314. Structural evidence that puromycin hydrolase is a new type of aminopeptidase with a prolyl oligopeptidase family fold, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 79(10), 2999-3005, 201110
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  315. Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 201004
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  316. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 20110826
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  317. Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway, JOURNAL OF BACTERIOLOGY, 195(8), 1741-1749, 201304
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  318. Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 201204
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  319. Identification and kinetic study of tyrosinase inhibitors found in sake lees, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(26), 9827-9833, 20061227
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  320. A novel tyrosine-phosphorylated protein inhibiting the growth of Streptomyces cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385(4), 534-538, 20090807
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  321. Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent D-Cycloserine Produced by Streptomyces lavendulae, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(3), 1132-1139, 201003
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  322. A novel assay method for an amino acid racemase reaction based on circular dichroism, BIOCHEMICAL JOURNAL, 389, 491-496, 20050715
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  323. Establishment of an In Vitro D-Cycloserine-Synthesizing System by Using O-Ureido-L-Serine Synthase and D-Cycloserine Synthetase Found in the Biosynthetic Pathway, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 57(6), 2603-2612, 201306
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  324. Purification and characterization of the second Streptomyces phospholipase A(2) refolded from an inclusion body, PROTEIN EXPRESSION AND PURIFICATION, 50(1), 82-88, 200611
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  325. Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis, JOURNAL OF BIOLOGICAL CHEMISTRY, 281(13), 8981-8990, 20060331
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  326. The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: Crystallographic analysis to elucidate the binding mode of the antibiotic to the protein, JOURNAL OF MOLECULAR BIOLOGY, 360(2), 398-408, 20060707
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  327. Catalytic Mechanism of Bleomycin N-Acetyltransferase Proposed on the Basis of Its Crystal Structure, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(2), 1446-1456, 20100108
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  328. Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 378(3), 574-578, 20090116
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  329. Establishment of an Efficient Fermentation System of Gamma-Aminobutyric Acid by a Lactic Acid Bacterium, Enterococcus avium G-15, Isolated from Carrot Leaves, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(10), 1673-1679, 201010
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  330. Molecular Cloning and Functional Analysis of minD Gene from Streptomyces lavendulae ATCC25233, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 106(3), 303-305, 200809
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  331. Cloning and characterization of a Streptomyces single module type non-ribosomal peptide synthetase catalyzing a blue pigment synthesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 282(12), 9073-9081, 20070323
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  332. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 201002
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  333. The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), 20120217
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  334. Metabolic Engineering of Pediococcus acidilactici BD16 for Heterologous Expression of Synthetic alaD Gene Cassette and L-Alanine Production in the Recombinant Strain Using Fed-Batch Fermentation, FOODS, 10(8), 202108
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  335. Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding, JOURNAL OF VIROLOGY, 95(19), 202110
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  336. Optimization of L-alanine production in the recombinant Pediococcus acidilactici BD16 (alaD(+)), BIOCHEMICAL ENGINEERING JOURNAL, 177, 202201
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  337. Application of Pediococcus acidilactici BD16 (alaD (+)) expressing L-alanine dehydrogenase enzyme as a starter culture candidate for secondary wine fermentation, BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 35(1), 1643-1661, 20210101
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  338. Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, NUTRIENTS, 13(11), 202111
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  339. The Exopolysaccharide Produced by Lactobacillus paracasei IJH-SONE68 Prevents and Ameliorates Inflammatory Responses in DSS-Induced Ulcerative Colitis, MICROORGANISMS, 9(11), 202111
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Publications such as books

  1. 1994/12/14, Antibiotics produced by ┣DBStreptomyces(/)-┫DB host-vector systems. , In Recombinant Microbes for industrial and agricultural applications, marcel dekker= inc., 1994, 12, Scholarly Book, Joint work, en, 896
  2. 2012/09, Advanced Technology for Microbiological Production in Japan, 微生物の物質資産について，その技術，応用の最新の状況, 2012, 10, Scholarly Book, Joint work, jp, ISBN-10:4781306586,ISBN-13:978-4781306582, 223, p186-193
  3. 2014, Microbiol Production , From Genome Design to Cell Engineering Structure of Tyrosinase and Its Inhibitor from Sake Lees, Springer, 2014, Scholarly Book, Joint work, en, Anazawa, H. ; Shimizu, S. (Eds.) , 978-4-431-54606-1, 306, pp.243-249

Invited Lecture, Oral Presentation, Poster Presentation

  1. Mechanism for expression of the bacteriocin 174A biosynthetic gene cluster harbored in a plant-derived Lactobacillus brevis, Noda, M., Miyauchi, R., Danshiitsoodol,N., Kumagai, T., Matoba, Y., Sugiyama, M., 5th AFSLAB International Symposium, 2016/11/28, Without Invitation, English, Asian Federation of Societies for Lactic Acid Bacteria, Taipei, Taiwan
  2. Biosurfactant derived from Lactobacillus reuteri BM53-1 inhibits production of TSST-1 by Streptococcus aureus at the transcriptional level., Danshiitsoodol,N., Noda, M., Sugimoto, Y., Sugiyama, M., 5th AFSLAB International Symposium, 2016/11/28, Without Invitation, English, Asian Federation of Societies for Lactic Acid Bacteria, Taipei, Taiwan

Awards

  1. 2011/09/04, The 14th John M. Kinney Award for General Nutrition, The Nutritional Sciences,Education & Research Fund (NSERF) と国際栄養科学雑誌「Nutrition」との連名, 植物乳酸菌が便秘と肝機能の改善に優れていることのヒト臨床試験による実証

Patented

  1. Patent, TW：I727293, 2021/05/11, COMPOSITION FOR TYPE IV ALLERGY
  2. Patent, CA：3086031, 2021/11/23, COMPOSITION FOR TYPE IV ALLERGY
  3. Patent, AU：2019260953, 2021/05/06, COMPOSITION FOR TYPE IV ALLERGY
  4. Patent, KR：10-2368628, 2022/02/23, COMPOSITION FOR TYPE IV ALLERGY
  5. Patent, EP：3714701, 2022/08/10, COMPOSITION FOR TYPE IV ALLERGY
  6. Patent, 6679202, 2020/03/23, COMPOSITION FOR TYPE IV ALLERGY
  7. Patent, TW：I739078, 2021/09/11, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  8. Patent, CA：3086024, 2022/02/08, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  9. Patent, AU：2019260952, 2021/02/25, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  10. Patent, KR：10-2368627, 2022/02/23, COMPOSITION FOR SUPPRESSING FAT ACCUMULATION
  11. Patent, 6649539, 2020/01/21, COMPOSITION FOR SPPRESSING FAT ACCUMULATION
  12. Patent, TW：I746955, 2021/11/21, COMPOSITION FOR TYPE I ALLERGY
  13. Patent, CA：3085995, 2022/03/08, COMPOSITION FOR TYPE I ALLERGY
  14. Patent, AU：2019260951, 2021/03/25, COMPOSITION FOR TYPE I ALLERGY
  15. Patent, KR：10-2368626, 2022/02/23, COMPOSITION FOR TYPE I ALLERGY
  16. Patent, 6648348, 2020/01/17, COMPOSITION FOR TYPE I ALLERGY
  17. Patent, TW：I713850, 2020/12/21, Nobel lactic acid bacteria and use thereof
  18. Patent, NZ：750198, 2022/10/04, Nobel lactic acid bacteria and use thereof
  19. Patent, CA：3032579, 2020/06/16, Nobel lactic acid bacteria and use thereof
  20. Patent, AU:2018281512, 2020/07/09, Nobel lactic acid bacteria and use thereof
  21. Patent, KR：10-2361556, 2022/02/07, Nobel lactic acid bacteria and use thereof
  22. Patent, 6523579, 2019/05/10, Nobel lactic acid bacteria and use thereof
  23. Patent, TW:I696465, 2020/06/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  24. Patent, NZ: 750188, 2022/08/02, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  25. Patent, CA:3032572, 2020/04/21, NEW LACTIC ACID BACTERIUM AND USE THEREOF
  26. Patent, AU:2018281511, 2020/07/30, NEW LACTIC ACID BACTERIUM AND THEREOF
  27. Patent, KR:10-2313677, 2021/10/12, NEW LACTIC ACID BACTERUM AND USE THEREOF
  28. Patent, US:11447740, 2022/09/20, NEW LACTIC ACID BACTERUM AND USE THEREOF

Social Activities

Organizing Academic Conferences, etc.

  1. Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/03, 2009/03
  2. The 2nd International Symposium for Lactic Acid Bacteria to Prevented to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive and Pre-sympomatic Medicine, Representative, 2009/12, 2009/12
  3. The 3rd International Symposium for Lactic Acid Bacteria to Urge Industry-University Cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2010/12, 2010/12
  4. The 4th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2011/12, 2011/12
  5. The 5th Korea-Japan-China International Symposium to Promote Industry-Academia-Government cooperation Contribution of Lactic acid Bacteria to Preventive Pre-symptomatic Medicine, Representative, 2012/12, 2012/12
  6. The 2013 Annual Meeting of the Society for Actinomycetes Japan Abstracts, 2013/09, 2013/09
  7. The 6th International Symposium for Probiotics to preventive & Pre-symptomatic Medicine, Representative, 2014/03, 2014/03
  8. 2014 Annual Meeting of The Japan Society for Lactic Acid Bacteria, 2014/07, 2014/07