SATOSHI ASANO

Last Updated :2025/04/11

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
sasanohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master, Shimane University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry

Research Keywords

  • vesicle transport
  • cell adhesion
  • Kinesin
  • cytokine
  • Insulin
  • cell migration

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  2. 2025, Undergraduate Education, 3Term, Dental Pharmacology I
  3. 2025, Undergraduate Education, 4Term, Dental Pharmacology II
  4. 2025, Undergraduate Education, 1Term, Practice of Pharmacology
  5. 2025, Undergraduate Education, First Semester, Dental Research Practices I
  6. 2025, Undergraduate Education, Second Semester, Dental Research Practices II
  7. 2025, Undergraduate Education, First Semester, Dental Research Practices III
  8. 2025, Undergraduate Education, 2Term, Dental Research Practices IV
  9. 2025, Undergraduate Education, 2Term, Pharmacology and Dental Pharmacology
  10. 2025, Undergraduate Education, Second Semester, Practice on Basic Dental Sciences
  11. 2025, Undergraduate Education, 2Term, Pharmacology and Dental Pharmacology

Research Activities

Academic Papers

  1. ★, Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Galpha(i) proteins, and to its functions in breast cancer cells, British Journal of Pharmacology, 20250410
  2. Brain region-specific neural activation by low-dose opioid promotes social behavior, JCI Insight, 9(23), e182060-e182060, 20241206
    Link to Paper Search Results by DOI
  3. ★, Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells, Journal of Pharmacological Sciences, 154(3), 139-147, 20240105
  4. ★, Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway, Peptides, 161, 170940, 20230106
  5. ★, Vasoactive intestinal peptide-VIPR2 signaling regulates tumor cell migration, FRONTIERS IN ONCOLOGY, 12, 20220927
    Link to Paper Search Results by DOI
  6. ★, Phospholipase C-related catalytically inactive protein enhances cisplatin-induced apoptotic cell death, EUROPEAN JOURNAL OF PHARMACOLOGY, 933, 20221015
    Link to Paper Search Results by DOI
  7. ★, Phospholipase c-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow, Scientific reports, 9(1), 12729-12742, 20190906
  8. Cyclic Peptides KS-133 and KS-487 Multifunctionalized Nanoparticles Enable Efficient Brain Targeting for Treating Schizophrenia, JACS Au, 20240701
  9. ★, Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling, Sci Rep, 7(1), 5408, 20170714
  10. ★, Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion, Biology Open, 3(5), 20140501
  11. ★, Phospholipase C-related catalytically inactive protein (PRIP) controls KIF5B-mediated insulin secretion, BIOLOGY OPEN, 3(6), 463-474, 20140615
    Link to Paper Search Results by DOI
  12. ★, Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway, Mol Cell Biol., 32(16), 3242-3252, 20120601
  13. ★, Expression of PRIP, a phosphatidylinositol 4,5-bisphosphate binding protein, attenuates PI3K/AKT signaling and suppresses tumor growth in a xenograft mouse model, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 552, 106-113, 20210509
    Link to Paper Search Results by DOI
  14. Development of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide for the treatment of schizophrenia, Folia Pharmacol. Jpn, 158(3), 242-245, 20230330
  15. A new method for assessing depressive-like behaviors in female mice, Nihon Yakurigaku Zasshi, 158(1), 35-38, 20230104
  16. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders, FRONTIERS IN PHARMACOLOGY, 12, 20211104
    Link to Paper Search Results by DOI
  17. Roles of the monoaminergic system in the antidepressant effects of ketamine and its metabolites, NEUROPHARMACOLOGY, 223, 20230201
    Link to Paper Search Results by DOI
  18. Imipramine prevents Porphyromonas gingivalis lipopolysaccharide- induced microglial neurotoxicity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 634, 92-99, 20221217
    Link to Paper Search Results by DOI
  19. AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 636, 10-16, 20221225
    Link to Paper Search Results by DOI
  20. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation, NEUROCHEMISTRY INTERNATIONAL, 160, 202211
    Link to Paper Search Results by DOI
  21. Probing the VIPR2 Microduplication Linkage to Schizophrenia in Animal and Cellular Models, FRONTIERS IN NEUROSCIENCE, 15, 20210722
    Link to Paper Search Results by DOI
  22. Activation of the VPAC2 Receptor Impairs Axon Outgrowth and Decreases Dendritic Arborization in Mouse Cortical Neurons by a PKA-Dependent Mechanism, FRONTIERS IN NEUROSCIENCE, 14, 20200604
    Link to Paper Search Results by DOI
  23. Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure, JOURNAL OF ORAL BIOSCIENCES, 61(2), 65-72, 201906
    Link to Paper Search Results by DOI
  24. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice, NEUROCHEMISTRY INTERNATIONAL, 131, 20191201
    Link to Paper Search Results by DOI
  25. Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice, Neurochemistry international, 131, 104563, 20191008
  26. Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice, BRAIN RESEARCH, 1680, 13-38, 20180201
    Link to Paper Search Results by DOI
  27. Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation, JAPANESE DENTAL SCIENCE REVIEW, 53(1), 18-24, 20170201
    Link to Paper Search Results by DOI
  28. General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice, J Anesth, 20170409
  29. Phospholipase C-related catalytically inactive protein-knockout mice exhibit uncoupling protein 1 upregulation in adipose tissues following chronic cold exposure, Journal of Oral Biosciences, 59(2), 108-112, 20170506
  30. General anesthetic actions on GABA(A) receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice, JOURNAL OF ANESTHESIA, 31(4), 531-538, 20170407
    Link to Paper Search Results by DOI
  31. Suppression of cell migration by phospholipase C-related catalytically inactive proteindependent modulation of PI3K signalling, SCIENTIFIC REPORTS, 7, 20170714
    Link to Paper Search Results by DOI
  32. Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by -Adrenergic Receptors in Brown Adipocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8), 4185-4196, 20160219
    Link to Paper Search Results by DOI
  33. Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblasts, PLOS ONE, 20140501
  34. Phospholipase C-related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase, PLOS ONE, 20140601
  35. Phospholipase C-Related Catalytically Inactive Protein Participates in the Autophagic Elimination of Staphylococcus aureus Infecting Mouse Embryonic Fibroblasts, PLOS ONE, 9(5), 20140527
    Link to Paper Search Results by DOI
  36. Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase, PLOS ONE, 9(6), 20140619
    Link to Paper Search Results by DOI
  37. Regulation of autophagy and its associated cell death by ""sphingolipid rheostat"", J Biol Chem., 287(47), 39898-39910, 20121101
  38. Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation, J Biol Chem., 286(41), 36053-36062, 20111001
  39. Ceramide-centered sphingolipid metabolism, Seikagaku, 83(6), 495-505, 20110801
  40. ★, Direct evidence for roles of phosphorylated regulatory light chain of myosin II in furrow ingression during cytokinesis in HeLa cells., Genes to Cells, 14, 555-568, 20090401

Invited Lecture, Oral Presentation, Poster Presentation

  1. A potent and highly selective VPAC2 receptor antagonist peptide KS-133 counteracts cognitive impairment in a mouse model relevant to schizophrenia, Yukio Ago, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Shinsaku Nakagawa, Satoshi Asano, Kotaro Sakamoto, The 60th Annual Meeting of the American College of Neuropsychopharmacology (ACNP), 2021/12/05, Without Invitation, English
  2. Overexpression of VIPR2 in neurons causes defects in dendritic growth and cognitive impairment, Tatsunori Miyaoka, Lu Chen, Mei Yamada, Daichi Koan, Satoshi Asano, Kenji Ishimoto, Shinsaku Nakagawa, Atsuko Hayata, Takanobu Nakazawa, Akihiro Harada, Hitoshi Hashimoto, James A. Waschek, Yukio Ago, The 7th Congress of the Asian College of Neuropsychopharmacology (AsCNP), 2021/08/22, Without Invitation, English
  3. Regulation of tumor cell migration by vasoactive intestinal peptide (VIP)−VPAC2 receptor signaling., Satoshi Asano, Misa Yamasaka, Kairi Ozasa, James A. Waschek, Yukio Ago, The 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English
  4. Abnormal pain sensitivity in a prenatal valproic acid-induced mouse model of autism spectrum disorder., Eiji Imado, Sun Samnang, Abrar Rizal Abawa, Satoshi Asano, Kazuhiro Tsuga, Masahiro Irifune, Yukio Ago, The 6th Joint Scientific Meeting in Dentistry, 2021/07/30, Without Invitation, English
  5. Regulation of cell adhesion by phospholipase C-related catalytically inactive protein (PRIP); PRIP directly binds to talin1 and promotes talin1 dimerization, Satoshi Asano, Takashi Kanematsu, 2019/06/15, Without Invitation, English
  6. PRIP regulates talin1 dimerization by binding to its dimerization domain, and controls fibronectin/integrin-mediated cell adhesion, Satoshi Asano, Takashi Kanematsu, 2019/10/12, Without Invitation, English
  7. Suppression of breast cancer cell migration by PRIP, an upstream regulation of phosphoinositide 3-kinase signaling pathway, Asano Satoshi, Kanematsu Takashi, 2015/06/27, Without Invitation, English
  8. Regulation of cell migration by phospholipase C-related catalytically inactive protein, Asano Satoshi, Kanematsu Takashi, 2014/09/25, Without Invitation, Japanese
  9. Regulation of insulin secretion by phospholipase C-related catalytically inactive protein, Asano Satoshi, Kanematsu Takashi, 2013/09/20, Without Invitation, English
  10. Phospholipase C-related catalytically inactive protein modulates insulin secretory vesicle movement, Asano Satoshi, Kanematsu Takashi, 5th Hiroshima Conference on Education and Science, 2013/10/12, Without Invitation, English
  11. Regulation of second phase of insulin secretion by phospholipase C-related catalytically inactive protein, Asano Satoshi, Kanematsu Takashi, 46th meeting of the Hiroshima University Dental Society, 2013/06/29, Without Invitation, English
  12. Novel mechanisms of insulin vesicle transport in the KIF5-mediated insulin secretion, Asano Satoshi, Kanematsu Takashi, The 8th Japan-Korea conference on cellular signalling for young scientists, 2013/11/07, Without Invitation, English
  13. PRIP represses GABARAP-mediated interaction between KIF5 and insulin-containing vesicles, Asano Satoshi, Kanematsu Takashi, 2012/12/14, Without Invitation, English
  14. Sphingomyelin inhibits CXCL12-induced cell migration, Asano Satoshi, 2010/12/07, Without Invitation, English
  15. Tumor cell migration is regulated by PRIP-mediated phosphatidylinositol turnover, Asano Satoshi, Kanematsu Takashi, 2016/03/09, Without Invitation, Japanese
  16. Suppression of PI3K-dependent breast cancer cell migration by PRIP, Asano Satoshi, Kanematsu Takashi, GAP (Global Academic Program) related meeting, 2016/07/22, Without Invitation, English
  17. Expression of phospholipase C-related catalytically inactive protein suppresses cancerous metastasis, Asano Satoshi, Kanematsu Takashi, 2017/03/15, Without Invitation, Japanese
  18. Over expression of PRIP in MCF-7 cells, a breast cancer cell line, enhances cisplatin induced apoptosis, Yuka Maetani, Satoshi Asano, Masahiro Irifune, Takashi Kanematsu, 2017/06/29, Without Invitation, Japanese
  19. Regulation of cytokinesis by phospholipase C-related catalytically inactive protein, as a sequestrant of PI(4,5)P2 in the cleavage furrow, Satoshi Asano, Takashi Kanematsu, 2017/09/17, Without Invitation, English
  20. The mechanism of phospholipase C-related catalytically inactive protein (PRIP)-mediated energy metabolism by beta-adrenergic stimulation in brown adipocytes, 2017/09/17, Without Invitation, English
  21. PI(4,5)P2 metabolism regulator PRIP controls the metastatic potential in breast cancer cells, Satoshi Asano, Takashi Kanematsu, 2018/05/27, Without Invitation, Japanese
  22. Overexpression of PRIP in MCF-7 cells, a breast cancer cell line, enhances cisplatin-induced apoptosis, Satoshi Asano, Yuka Maetani, Yasuka Ikura, Takashi Kanematsu, The 18th World Congress of Basic and Clinical Pharmacology (WCP2018), 2018/07/04, Without Invitation, English
  23. Novel phosphatidylinositol metabolism regulator controls the metastatic potential in breast cancer cells, Satoshi Asano, 2018/09/05, With Invitation, English, 福岡市・九州大学医学部百年講堂
  24. PRIP protects PI(4,5)P2 from its metabolic enzyme and contributes to completion of cytokinesis, Yasuka Ikura, Asano Satoshi, Kanematsu Takashi, 7th Hiroshima Conference, 2018/03/29, Without Invitation, English
  25. PRIP modulates AKT–GSK3β signaling and regulates cell cycle progression, Yuka Maetani, Satoshi Asano, Masahiro Irifune, Takashi Kanematsu, The 51th Annual Meeting of the Hiroshima University Dental Society, 2018/06, Without Invitation, English
  26. Expression of PRIP in breast cancer cells downregulates tumor growth, Yuka Maetani, Satoshi Asano , Takashi Kanematsu, The 60th Annual Meetings of Japanese Association for Oral Biology, 2018/09/05, Without Invitation, English