YUUKI KOBAYASHI

Last Updated :2024/05/08

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
ykobahiroshima-u.ac.jp
Other Contact Details
"KAGAMIYAMA 1-7-1, HIGASHI-HIROSHIMA", Japan, Japan
TEL : (+81)82-424-6403 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2024/04/01, Hiroshima University, Associate Professor
  • 2023/02/27, 2024/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor (Special Recognition)
  • 2019/04/01, 2024/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2014/10/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2014/04/01, 2014/09/30, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor (Special Appointment)
  • 2011/04/01, 2014/03/31, hiroshima university, Research Fellow of the Japan Society for the Promotion of Science (PD)
  • 2008/04/01, 2011/03/31, kitasato university, Research Fellow of the Japan Society for the Promotion of Science (DC1)

Educational Backgrounds

  • Kitasato University, Japan, 2002/04, 2006/03
  • Kitasato University, Japan, 2006/04, 2008/03
  • Kitasato University, Japan, 2008/04, 2011/03

Academic Degrees

  • Doctor of Philosophy, Kitasato University
  • Master, Kitasato University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences

In Charge of Primary Major Programs

  • Life Sciences

Research Fields

  • Biology;Biological Science;Molecular biology

Research Keywords

  • GPCR, primary cilia, endocrinology, neuroscience

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Brain and Behavior
  2. 2024, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  3. 2024, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  4. 2024, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  5. 2024, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  6. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  7. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  8. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  9. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  10. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  11. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  12. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  13. 2024, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  14. 2024, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  15. 2024, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  16. 2024, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  17. 2024, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  18. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  19. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  20. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  21. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  22. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  23. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  24. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  25. 2024, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  26. 2024, Undergraduate Education, 1Term, Brain Science
  27. 2024, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  28. 2024, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  29. 2024, Undergraduate Education, 3Term, Seminar in English for Life Sciences
  30. 2024, Undergraduate Education, 2Term, Introduction to Life Sciences
  31. 2024, Undergraduate Education, 2Term, Cell Biology
  32. 2024, Undergraduate Education, 2Term, Laboratory Work in Life Sciences D
  33. 2024, Undergraduate Education, 2Term, Practical Methods in Life Sciences D
  34. 2024, Undergraduate Education, Intensive, Lecture and Laboratory courseIn Marine Biology
  35. 2024, Undergraduate Education, First Semester, Fundamental Laboratory Work in Biology
  36. 2024, Undergraduate Education, First Semester, Fundamental Methodology in Biology
  37. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  38. 2024, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
  39. 2024, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
  40. 2024, Graduate Education (Master's Program) , First Semester, Molecular and Cellular Neurobiology I
  41. 2024, Graduate Education (Master's Program) , Second Semester, Molecular and Cellular Neurobiology II

Research Activities

Academic Papers

  1. ★, Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 610, 85-91, 20220625
  2. ★, Ciliary GPCR-based transcriptome as a key regulator of cilia length control, FASEB BioAdvances, DOI: 10.1096/fba.2021-00029, 202106
  3. Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro, NEUROCHEMISTRY INTERNATIONAL, 142, 202101
  4. ★, New perspectives on GPCRs: GPCR heterodimer formation (melanocortin receptor) and GPCR on primary cilia (melanin concentrating hormone receptor), General and Comparative Endocrinology, 293(1), https://doi.org/10.1016/j.ygcen.2020.113474, 202006
  5. Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia, MICROSCOPY, 69(5), 275-285, 202010
  6. ★, Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons., Neurochem Res., 44(7), 201906
  7. Selective signaling pathway via feeding-related ciliary GPCR, melanin-concentrating hormone receptor 1, Nihon Yakurigaku Zasshi, 154(4), 179-185, 201905
  8. ★, Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8)., Neuroscience., 15(383), 160-169, 201806
  9. a-Melanocyte-stimulating hormone directly increases the plasma calcitonin level and involves calcium metabolism in goldfish, 10, 283-292, 201809
  10. ★, Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1., Gen Comp Endocrinol., 253:44-52, 44, 201711
  11. Modulation of primary cilia length by melanin-concentrating hormone receptor 1, CELLULAR SIGNALLING, 28(6), 572-584, 201606
  12. ★, Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 230, 103-109, 201605
  13. Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1, CELLULAR SIGNALLING, 27(4), 818-827, 201504
  14. ★, Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 212, 114-123, 201504
  15. Involvement of melanin-concentrating hormone 2 in background color adaptation of barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 214, 140-148, 201504
  16. ★, Inhibitory effects of beta-endorphin on cortisol release from goldfish (Carassius auratus) head kidney: An in vitro study, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 204, 126-134, 201408
  17. The pituitary-interrenal axis of fish: A review focusing on the lamprey and flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 188, 54-59, 201305
  18. Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change: Roles emerging from barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 181, 229-234, 201301
  19. Food Deprivation Increases the Expression of the Prepro-orexin Gene in the Hypothalamus of the Barfin Flounder, Verasper moseri, ZOOLOGICAL SCIENCE, 29(1), 43-48, 201201
  20. ★, Further evidence on acetylation-induced inhibition of the pigment-dispersing activity of alpha-melanocyte-stimulating hormone, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 176(1), 9-17, 201205
  21. ★, Pigment-dispersing activities and cortisol-releasing activities of melanocortins and their receptors in xanthophores and head kidneys of the goldfish Carassius auratus, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 173(3), 438-446, 201109
  22. ★, Melanocortin receptor subtypes in interrenal cells and corticotropic activity of alpha-melanocyte-stimulating hormones in barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 170(3), 558-568, 201102
  23. Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 171(1), 75-81, 2011
  24. ★, Differential expressions of melanocortin receptor subtypes in melanophores and xanthophores of barfin flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 168(1), 133-142, 2010
  25. Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish, PEPTIDES, 30(11), 1990-1996, 2009
  26. Structural and functional diversity of proopiomelanocortin in fish with special reference to barfin flounder, PEPTIDES, 30(7), 1374-1382, 2009
  27. ★, Possible paracrine function of alpha-melanocyte-stimulating hormone and inhibition of its melanin-dispersing activity by N-terminal acetylation in the skin of the barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 161(3), 419-424, 2009
  28. ★, Transcription elements and functional expression of proopiomelanocortin genes in the pituitary gland of the barfin flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 158(3), 259-267, 2008
  29. Evaluation of posttranslational processing of proopiomelanocortin in the banded houndshark pituitary by combined cDNA cloning and mass spectrometry, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 157(1), 41-48, 2008
  30. ★, Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 155(2), 280-287, 2008
  31. ★, cDNA cloning of proopiomelanocortin (POMC) and mass spectrometric identification of POMC-derived peptides from snake and alligator pituitaries, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 152(1), 73-81, 2007
  32. The melanin-concentrating hormone receptor 2 (MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 151(2), 210-219, 2007
  33. Primary cilia (energy and metabolism ), Clinical Neuroscience, 40, 276-278, 202203
  34. ★, Photic environment and fish growth: impact of results obtained in flatfish barfin flounder on this new research field, Jasco report, 52(2), 20-29, 201010

Publications such as books

  1. 2021/06, Handbook of Hormones. Comparative Endocrinology for Basic and Clinical Research, second edition, Dictionary/Encyclopedia, Contributor
  2. 2017/12, Encyclopedia of Signaling Molecules, 2nd Edition, Dictionary/Encyclopedia, Joint work, English
  3. 2015/09, Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Scholarly Book, Joint work, English

Invited Lecture, Oral Presentation, Poster Presentation

  1. Metabolic GPCR-mediated primary cilia shortening through dynamic cytoskeletal reorganization, 2017/09, Without Invitation, English
  2. Shortening of primary cilia length by melanin-concentrating hormone receptor 1-Gi/o mediated signaling., Yumiko Saito, Akie Hamamoto, Sakura Tomoshige, Shogo Yamato, Tatsuo Miyamoto, Kosuke Hosoba, Yuki Kobayashi., The 28th CDB Meeting, Cilia and Centrosomes, 2016/11, Without Invitation, English, CDB
  3. Melanin-concentrating hormone-mediated signaling induces cilium shortening via Gi/o-dependent Akt phosphorylation., Saito Y, Hamamoto A, Yamoto S, Kobayashi Y., Neuroscience 2016, 2016/11, Without Invitation, English, San Diego

Social Activities

Organizing Academic Conferences, etc.

  1. 2016/11, 2017/12
  2. 2016/08, 2017/09
  3. Japan Biology Olympiad 2015, 2015/04, 2015/09
  4. CompBiol2015, 2014/08, 2015/12
  5. 2014/08, 2015/12
  6. 2014/08, 2015/12