YUUKI KOBAYASHI

Last Updated :2025/06/04

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
ykobahiroshima-u.ac.jp
Other Contact Details
"KAGAMIYAMA 1-7-1, HIGASHI-HIROSHIMA", Japan, Japan
TEL : (+81)82-424-6403 FAX : (+81)

Basic Information

Major Professional Backgrounds

  • 2024/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor
  • 2023/02/27, 2024/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor (Special Recognition)
  • 2019/04/01, 2024/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2014/10/01, 2019/03/31, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor
  • 2014/04/01, 2014/09/30, Hiroshima University, Graduate School of Integrated Arts and Sciences, Assistant Professor (Special Appointment)
  • 2011/04/01, 2014/03/31, hiroshima university, Research Fellow of the Japan Society for the Promotion of Science (PD)
  • 2008/04/01, 2011/03/31, kitasato university, Research Fellow of the Japan Society for the Promotion of Science (DC1)

Educational Backgrounds

  • Kitasato University, Japan, 2002/04, 2006/03
  • Kitasato University, Japan, 2006/04, 2008/03
  • Kitasato University, Japan, 2008/04, 2011/03

Academic Degrees

  • Doctor of Philosophy, Kitasato University
  • Master, Kitasato University

Educational Activity

  • [Bachelor Degree Program] School of Integrated Arts and Sciences : Department of Integrated Arts and Sciences : Integrated Arts and Sciences
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Life and Environmental Sciences

In Charge of Primary Major Programs

  • Life Sciences

Research Fields

  • Biology;Biological Science;Molecular biology

Research Keywords

  • GPCR, primary cilia, endocrinology, neuroscience

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, Brain and Behavior
  2. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Science A
  3. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  4. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  5. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  6. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  7. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  8. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  9. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  10. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  11. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  12. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  13. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  14. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  15. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  16. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  17. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  18. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  19. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  20. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  21. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  22. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  23. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  24. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  25. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  26. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  27. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  28. 2025, Undergraduate Education, 1Term, Applied Behavioral Sciences
  29. 2025, Undergraduate Education, 1Term, Brain Science
  30. 2025, Undergraduate Education, Second Semester, Laboratory Work in Natural Sciences
  31. 2025, Undergraduate Education, Second Semester, Practical Methods in Natural Sciences
  32. 2025, Undergraduate Education, 3Term, Seminar in English for Life Sciences
  33. 2025, Undergraduate Education, 2Term, Introduction to Life Sciences
  34. 2025, Undergraduate Education, 2Term, Cell Biology
  35. 2025, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  36. 2025, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  37. 2025, Undergraduate Education, 2Term, Laboratory Work in Life Sciences D
  38. 2025, Undergraduate Education, 2Term, Practical Methods in Life Sciences D
  39. 2025, Undergraduate Education, Intensive, Lecture and Laboratory courseIn Marine Biology
  40. 2025, Undergraduate Education, First Semester, Fundamental Laboratory Work in Biology
  41. 2025, Undergraduate Education, First Semester, Fundamental Methodology in Biology
  42. 2025, Graduate Education (Master's Program) , Year, Research for Academic Degree Dissertation in Life and Environmental Sciences
  43. 2025, Graduate Education (Master's Program) , First Semester, Exercises in Life and Environmental Sciences A
  44. 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Life and Environmental Sciences B
  45. 2025, Graduate Education (Master's Program) , 2Term, Seminar in Integrated Arts and Sciences
  46. 2025, Graduate Education (Master's Program) , First Semester, Molecular and Cellular Neurobiology I
  47. 2025, Graduate Education (Master's Program) , Second Semester, Molecular and Cellular Neurobiology II

Research Activities

Academic Papers

  1. ★, Correlation between persistent changes in ciliary dynamics in the FrA and depressive-like behavior., Biochemical and biophysical research communications, 20250406
  2. Ciliary length variations impact cilia-mediated signaling and biological responses., Journal of biochemistry, 20240808
  3. ★, Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 610, 85-91, 20220625
    Link to Paper Search Results by DOI
  4. ★, Ciliary GPCR-based transcriptome as a key regulator of cilia length control, FASEB BioAdvances, DOI: 10.1096/fba.2021-00029, 202106
  5. Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro, NEUROCHEMISTRY INTERNATIONAL, 142, 202101
    Link to Paper Search Results by DOI
  6. ★, New perspectives on GPCRs: GPCR heterodimer formation (melanocortin receptor) and GPCR on primary cilia (melanin concentrating hormone receptor), General and Comparative Endocrinology, 293(1), https://doi.org/10.1016/j.ygcen.2020.113474, 202006
  7. Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia, MICROSCOPY, 69(5), 275-285, 202010
    Link to Paper Search Results by DOI
  8. ★, Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons., Neurochem Res., 44(7), 201906
  9. Selective signaling pathway via feeding-related ciliary GPCR, melanin-concentrating hormone receptor 1, Nihon Yakurigaku Zasshi, 154(4), 179-185, 201905
  10. ★, Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8)., Neuroscience., 15(383), 160-169, 201806
    Link to Paper Search Results by DOI
  11. a-Melanocyte-stimulating hormone directly increases the plasma calcitonin level and involves calcium metabolism in goldfish, 10, 283-292, 201809
  12. ★, Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1., Gen Comp Endocrinol., 253:44-52, 44, 201711
  13. Modulation of primary cilia length by melanin-concentrating hormone receptor 1, CELLULAR SIGNALLING, 28(6), 572-584, 201606
    Link to Paper Search Results by DOI
  14. ★, Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 230, 103-109, 201605
    Link to Paper Search Results by DOI
  15. Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1, CELLULAR SIGNALLING, 27(4), 818-827, 201504
    Link to Paper Search Results by DOI
  16. ★, Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 212, 114-123, 201504
    Link to Paper Search Results by DOI
  17. Involvement of melanin-concentrating hormone 2 in background color adaptation of barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 214, 140-148, 201504
    Link to Paper Search Results by DOI
  18. ★, Inhibitory effects of beta-endorphin on cortisol release from goldfish (Carassius auratus) head kidney: An in vitro study, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 204, 126-134, 201408
  19. The pituitary-interrenal axis of fish: A review focusing on the lamprey and flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 188, 54-59, 201305
  20. Interrelation between melanocyte-stimulating hormone and melanin-concentrating hormone in physiological body color change: Roles emerging from barfin flounder Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 181, 229-234, 201301
  21. Food Deprivation Increases the Expression of the Prepro-orexin Gene in the Hypothalamus of the Barfin Flounder, Verasper moseri, ZOOLOGICAL SCIENCE, 29(1), 43-48, 201201
  22. ★, Further evidence on acetylation-induced inhibition of the pigment-dispersing activity of alpha-melanocyte-stimulating hormone, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 176(1), 9-17, 201205
  23. ★, Pigment-dispersing activities and cortisol-releasing activities of melanocortins and their receptors in xanthophores and head kidneys of the goldfish Carassius auratus, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 173(3), 438-446, 201109
  24. ★, Melanocortin receptor subtypes in interrenal cells and corticotropic activity of alpha-melanocyte-stimulating hormones in barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 170(3), 558-568, 201102
  25. Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 171(1), 75-81, 2011
  26. ★, Differential expressions of melanocortin receptor subtypes in melanophores and xanthophores of barfin flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 168(1), 133-142, 2010
  27. Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish, PEPTIDES, 30(11), 1990-1996, 2009
  28. Structural and functional diversity of proopiomelanocortin in fish with special reference to barfin flounder, PEPTIDES, 30(7), 1374-1382, 2009
  29. ★, Possible paracrine function of alpha-melanocyte-stimulating hormone and inhibition of its melanin-dispersing activity by N-terminal acetylation in the skin of the barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 161(3), 419-424, 2009
  30. ★, Transcription elements and functional expression of proopiomelanocortin genes in the pituitary gland of the barfin flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 158(3), 259-267, 2008
  31. Evaluation of posttranslational processing of proopiomelanocortin in the banded houndshark pituitary by combined cDNA cloning and mass spectrometry, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 157(1), 41-48, 2008
  32. ★, Food deprivation increases the expression of melanocortin-4 receptor in the liver of barfin flounder, Verasper moseri, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 155(2), 280-287, 2008
  33. ★, cDNA cloning of proopiomelanocortin (POMC) and mass spectrometric identification of POMC-derived peptides from snake and alligator pituitaries, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 152(1), 73-81, 2007
  34. The melanin-concentrating hormone receptor 2 (MCH-R2) mediates the effect of MCH to control body color for background adaptation in the barfin flounder, GENERAL AND COMPARATIVE ENDOCRINOLOGY, 151(2), 210-219, 2007
  35. Primary cilia (energy and metabolism ), Clinical Neuroscience, 40, 276-278, 202203
  36. ★, Photic environment and fish growth: impact of results obtained in flatfish barfin flounder on this new research field, Jasco report, 52(2), 20-29, 201010

Publications such as books

  1. 2021/06, Handbook of Hormones. Comparative Endocrinology for Basic and Clinical Research, second edition, Dictionary/Encyclopedia, Contributor
  2. 2017/12, Encyclopedia of Signaling Molecules, 2nd Edition, Dictionary/Encyclopedia, Joint work, English
  3. 2015/09, Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Scholarly Book, Joint work, English
    Amazon URL

Invited Lecture, Oral Presentation, Poster Presentation

  1. Metabolic GPCR-mediated primary cilia shortening through dynamic cytoskeletal reorganization, 2017/09, Without Invitation, English
  2. Shortening of primary cilia length by melanin-concentrating hormone receptor 1-Gi/o mediated signaling., Yumiko Saito, Akie Hamamoto, Sakura Tomoshige, Shogo Yamato, Tatsuo Miyamoto, Kosuke Hosoba, Yuki Kobayashi., The 28th CDB Meeting, Cilia and Centrosomes, 2016/11, Without Invitation, English, CDB
  3. Melanin-concentrating hormone-mediated signaling induces cilium shortening via Gi/o-dependent Akt phosphorylation., Saito Y, Hamamoto A, Yamoto S, Kobayashi Y., Neuroscience 2016, 2016/11, Without Invitation, English, San Diego

External Funds

Acceptance Results of Competitive Funds

  1. 2025, 2027
  2. 2022, 2024
  3. 2024, 2025
  4. 2023, 2025
  5. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2021, 2023
  6. KAKENHI, 2015, 2017
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  7. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2019
  8. 2011, 2013
  9. 2008, 2010

Social Activities

Organizing Academic Conferences, etc.

  1. 2016/11, 2017/12
  2. 2016/08, 2017/09
  3. Japan Biology Olympiad 2015, 2015/04, 2015/09
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  4. CompBiol2015, 2014/08, 2015/12
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  5. 2014/08, 2015/12
  6. 2014/08, 2015/12