MASASHI IKUTANI

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
mikutanihiroshima-u.ac.jp
Self-introduction
Our research team works on immune cells, involved in allergic diseases and biological homeostasis. To explore the causes of immune-related diseases, we analyze dynamics of particular immune cells.

Basic Information

Major Professional Backgrounds

  • 2008/04/01, University of Toyama, Graduate School of Medicine and Pharmaceutical Science for Research, Assistant Professor
  • 2013/04/01, University of Toyama, Graduate School of Medicine and Pharmaceutical Science for Research, Lecturer
  • 2016/04/01, National Center for Global Health and Medicine, Research Institute, Researcher
  • 2017/02/01, National Center for Global Health and Medicine, Research Institute, Senior Researcher
  • 2020/07/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor

Academic Degrees

  • The University of New South Wales
  • The University of Tokyo

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology

Research Keywords

  • Immunology
  • Interleukin-5 (IL-5)
  • ILC2
  • Eosinophil
  • Interleukin-33 (IL-33)
  • PAH

Affiliated Academic Societies

  • Japanese Society of Immunology
  • The Japanese Society for Inflammation and Regeneration

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 4Term, Food and Life Science
  2. 2025, Undergraduate Education, Intensive, Laboratory Work in General Biology I
  3. 2025, Undergraduate Education, 4Term, Introduction to Applied Biological Science II
  4. 2025, Undergraduate Education, 4Term, Research Front of Food and AgriLife Science
  5. 2025, Undergraduate Education, 3Term, Bio-organic Chemistry
  6. 2025, Undergraduate Education, Second Semester, Graduation Thesis I
  7. 2025, Undergraduate Education, First Semester, Graduation Thesis II
  8. 2025, Undergraduate Education, Second Semester, Graduation Thesis III
  9. 2025, Undergraduate Education, Intensive, Problem Based Learning for Molecular Agro-Life ScienceII
  10. 2025, Undergraduate Education, 4Term, Bio-Analytical Science
  11. 2025, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  12. 2025, Undergraduate Education, Intensive, (AIMS)Molecular Agro-life Science
  13. 2025, Undergraduate Education, Intensive, Molecular Agro-life Science
  14. 2025, Graduate Education (Doctoral Program) , 1Term, Research Plans in Life Science
  15. 2025, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  16. 2025, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  17. 2025, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  18. 2025, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  19. 2025, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science

Research Activities

Academic Papers

  1. Omics in allergy and asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 154(6), 1378-1390, 202412
    Link to Paper Search Results by DOI
  2. IL-10 promotes Th17 cell differentiation by enhancing STAT1-dependent IL-6 production via IgE-stimulated mast cells, SCIENTIFIC REPORTS, 14(1), 20241104
    Link to Paper Search Results by DOI
  3. Characterization of long-term interleukin-33 administration as an animal model of pulmonary arterial hypertension, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 734, 20241119
    Link to Paper Search Results by DOI
  4. Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation, INTERNATIONAL IMMUNOLOGY, 35(11), 513-530, 20231107
    Link to Paper Search Results by DOI
  5. Characterization of novel, severely immunodeficient Prkdcex57/ex57 mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 678, 193-199, 20231020
    Link to Paper Search Results by DOI
  6. Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s, ALLERGY, 78(7), 1878-1892, 202307
    Link to Paper Search Results by DOI
  7. IL-25 contributes to development of chronic contact dermatitis in C57BL/6 mice, but not BALB/c mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 628, 57-63, 20221105
    Link to Paper Search Results by DOI
  8. Heterogeneity of Group 2 Innate Lymphoid Cells Defines Their Pleiotropic Roles in Cancer, Obesity, and Cardiovascular Diseases, FRONTIERS IN IMMUNOLOGY, 13, 20220629
    Link to Paper Search Results by DOI
  9. Betulin Attenuates TGF-beta 1-and PGE(2)-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 45(3), 339-353, 2022
  10. Direct platelet adhesion potentiates group 2 innate lymphoid cell functions, ALLERGY, 77(3), 843-855, 2022
    Link to Paper Search Results by DOI
  11. Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin, SCIENTIFIC REPORTS, 11(1), 2021
    Link to Paper Search Results by DOI
  12. Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 533(3), 493-500, 2020
    Link to Paper Search Results by DOI
  13. The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity, SCIENCE ADVANCES, 5(7), eaav8152, 2019
  14. ★, Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-mediated pulmonary arterial hypertrophy, IMMUNOBIOLOGY, 223(6-7), 486-492, 2018
  15. Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation, CELLULAR IMMUNOLOGY, 323, 33-40, 2018
  16. ★, Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy, JCI INSIGHT, 2(7), e90721, 2017
  17. A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS, SCIENTIFIC REPORTS, 7, 2017
  18. CD206(+) M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors, NATURE COMMUNICATIONS, 8, 2017
  19. Interferon-gamma constrains cytokine production of group 2 innate lymphoid cells, IMMUNOLOGY, 147(1), 21-29, 2016
  20. HIF-1 alpha in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance, DIABETES, 65(12), 3649-3659, 2016
  21. Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells, IMMUNOLOGY LETTERS, 163(1), 22-31, 2015
  22. Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes, SCIENTIFIC REPORTS, 5, 2015
  23. ★, Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice, IMMUNOBIOLOGY, 220(5), 597-604, 2015
  24. Emerging roles of IL-33 in inflammation and immune regulation, Inflammation and Regeneration, 35(2), 069-077, 2015
  25. Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(21), 14796-14811, 2014
  26. Lnk prevents inflammatory CD8+T-cell proliferation and contributes to intestinal homeostasis, EUROPEAN JOURNAL OF IMMUNOLOGY, 44(6), 1622-1632, 2014
  27. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation, JOURNAL OF LEUKOCYTE BIOLOGY, 96(6), 1087-1100, 2014
  28. Roles of IL-5-producing Group 2 Innate Lymphoid Cells in Eosinophil Regulation, Inflammation and Regeneration, 34(3), 140-148, 2014
  29. Interleukin-5 Plays a Key Role in Mouse Strain-Dependent Susceptibility to Contact Hypersensitivity through Its Effects on Initiator B Cells, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 161, 98-106, 2013
  30. Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1 alpha-dependent and HIF-1 alpha-independent manner in obese mice, DIABETOLOGIA, 56(6), 1403-1412, 2013
  31. ★, Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity, JOURNAL OF IMMUNOLOGY, 188(2), 703-713, 2012
  32. Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL1pr/1pr mice, MOLECULAR IMMUNOLOGY, 49(4), 611-620, 2012
  33. Structural basis of interleukin-5 dimer recognition by its a receptor, PROTEIN SCIENCE, 21(6), 850-864, 2012
  34. The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells, INTERNATIONAL IMMUNOLOGY, 24(6), 389-400, 2012
  35. Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice, ENDOCRINOLOGY, 152(5), 1789-1799, 2011
  36. Expression of IL-5R alpha on B-1 cell progenitors in mouse fetal liver and involvement of Bruton's tyrosine kinase in their development, IMMUNOLOGY LETTERS, 123(2), 169-178, 2009
  37. Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice, DIABETES, 58(11), 2574-2582, 2009
  38. Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 140(S1), 8-16, 2006
  39. Partitioning of rearranged Ig genes by mutation analysis demonstrates D-D fusion and V gene replacement in the expressed human repertoire, JOURNAL OF IMMUNOLOGY, 172(1), 340-348, 2004

Publications such as books

  1. 2011/09, Inflammation and Allergy Drug Design, Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract. Chapter 6 Regulatory Roles of B Cells in Allergy and Inflammation, Wiley-Blackwell, Scholarly Book, Joint work, 9781444330144

Invited Lecture, Oral Presentation, Poster Presentation

  1. Characterization of ILC2 in IL-33-induced chronic inflammation, Ikutani M, Tsuneyama K, Nakae S, Takatsu K, Takaki S, The 47th Annual Meeting of the Japanese Society for Immunology, 2018/12, Without Invitation, Japanese, Japanese Society of Immunology, Fukuoka
  2. Roles of IL-5-producing ILC2 in vascular pathogenesis, Ikutani M, Tsuneyama K, Nagai Y, Takatsu K, The 43th Annual Meeting of the Japanese Society for Immunology, 2014/12, Without Invitation, Japanese, Japanese Society of Immunology, Kyoto
  3. A newly identified lymphocyte and allergic inflammation, Ikutani M, The 3rd Toyama-Basel Joint Symposium on Pharmaceutical Research and Drug development, 2014/08/12, With Invitation, Toyama
  4. Characterization of IL-5-Producing Cells in the Peritoneal Cavity, Ikutani M, Itakura A, Kouro T, Nagai Y, Takatsu K, The 39th Annual Meeting of the Japanese Society for Immunology, 2009/12, Without Invitation, Japanese, Japanese Society of Immunology, Osaka
  5. A Hairy/Enhancer of Split Related Transcription Factor, a Target of Btk-Dependent PreBCR Signal, Controls Transition from ProB to PreB, Ikutani M, Kouro T, Takaki S, Takatsu K, The 37th Annual Meeting of the Japanese Society for Immunology, 2007/11, Without Invitation, Japanese, Japanese Society of Immunology, Tokyo
  6. Genes Involved in Btk-Dependent ProB to PreB Transition, Ikutani M, Kouro T, Takaki S, Takatsu K, Keystone symposia Biology of B cells in Health and Disease, 2007/02, Without Invitation, English, Canada
  7. Target Genes for Btk-Dependent Siganls Driving B cell Development, Ikutani M, Kouro T, Takaki S, Takatsu K, The 36th Annual Meeting of the Japanese Society for Immunology, 2006/12, Without Invitation, Japanese, Japanese Society of Immunology, Osaka
  8. Identification of c-mu Positive Cells with Pro-B Cell Phenotype in Stroma Co-culture, Ikutani M, Kouro T, Takatsu K, The 35th Annual Meeting of the Japanese Society for Immunology, 2005/12, Without Invitation, Japanese, Japanese Society for Immunology, Yokohama

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-Aid for Scientific Research (C), 2022, 2024
  2. Grant-in-Aid for Scientific Research (C), 2019, 2021
  3. IMSUT Joint Research Project, 2018
  4. Grant-in-Aid for Young Scientists (B), 2017, 2018
  5. Grant-in-Aid for Young Scientists (B), 2014, 2015
  6. IMSUT Joint Research Project, 2014, 2015
  7. Grant-in-Aid for Research Activity Start-up, 2008, 2009