SOSHI KANEMOTO

Last Updated :2025/06/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
E-mail
soshi-kanemotohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy, Nara Institute of Science and Technology
  • Master, Kyoto University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
  • Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology
  • Biology;Biological Science;Molecular biology
  • Medicine,dentistry, and pharmacy;Clinical surgery;Orthopaedic surgery

Research Keywords

  • apoptosis
  • ER stress

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2025, Undergraduate Education, Year, Physiology and Biochemistry
  3. 2025, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry

Research Activities

Academic Papers

  1. G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver., JOURNAL OF BIOCHEMISTRY, 176(1), 55-68, 20240318
    Link to Paper Search Results by DOI
  2. Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis, COMMUNICATIONS BIOLOGY, 5(1), 20220722
    Link to Paper Search Results by DOI
  3. Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis, FASEB JOURNAL, 35(2), 202102
  4. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 2019
  5. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9, 2018
  6. Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
    Link to Paper Search Results by DOI
  7. Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
    Link to Paper Search Results by DOI
  8. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
    Link to Paper Search Results by DOI
  9. ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 201709
  10. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
    Link to Paper Search Results by DOI
  11. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 20161117
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  12. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 20160803
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  13. The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy., Medical Research Archives
  14. ★, Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
    Link to Paper Search Results by DOI
  15. IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 20151116
    Link to Paper Search Results by DOI
  16. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 20151112
    Link to Paper Search Results by DOI
  17. Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), 20150508
    Link to Paper Search Results by DOI
  18. Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 13810-13820, 20140516
    Link to Paper Search Results by DOI
  19. ★, PROLIFERATION, DIFFERENTIATION AND AMYLOID-beta PRODUCTION IN NEURAL PROGENITOR CELLS ISOLATED FROM TGCRND8 MICE, NEUROSCIENCE, 261, 52-59, 20140307
    Link to Paper Search Results by DOI
  20. Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLOS ONE, 9(2), 20140203
    Link to Paper Search Results by DOI
  21. Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, MOLECULAR CELL, 53(1), 127-139, 201401
    Link to Paper Search Results by DOI
  22. Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLOS ONE, 8(1), 20130130
    Link to Paper Search Results by DOI
  23. Activation of OASIS family, ER stress transducers, is dependent on its stabilization, CELL DEATH AND DIFFERENTIATION, 19(12), 1939-1949, 201212
    Link to Paper Search Results by DOI
  24. Roles of Endoplasmic Reticulum Stress in Neurodegenerative Diseases., Translational Medicine, 2, e108, 20120101
  25. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, SCIENTIFIC REPORTS, 2, 20121112
    Link to Paper Search Results by DOI
  26. The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(43), 36190-36200, 20121019
    Link to Paper Search Results by DOI
  27. Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation, NATURE COMMUNICATIONS, 3, 201207
    Link to Paper Search Results by DOI
  28. The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(11), 8144-8153, 20120309
    Link to Paper Search Results by DOI
  29. The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology, JOURNAL OF BIOCHEMISTRY, 149(5), 507-518, 201105
    Link to Paper Search Results by DOI
  30. Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors, IUBMB LIFE, 63(4), 233-239, 201104
    Link to Paper Search Results by DOI
  31. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis., Journal of Bone and Mineral Metabolism, 28, 131-138, 20100301
  32. Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis., Nature Cell Biology, 11, 1197-1204, 20091201
  33. Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation., Nature Cell Biology, 11, 1205-1211, 20091201
  34. TMP21 transmembrane domain regulates gamma-secretase cleavage., The Journal of Biological Chemistory, 284, 28634-28641, 20091001
  35. APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes., The Journal of Biological Chemistory, 284, 16298-16307, 20090401
  36. ★, A molecular chaperone inducer protects neurons from ER stress., Cell Death & Differentiation, 15, 364-375, 20080301
  37. Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type1., Human Molecular Genetics, 16, 2834-2843, 20071001
  38. Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle., Acta Neuropathologica, 114, 527-535, 20071001
  39. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer., Molecular and Cellular Biology, 27, 1716-1729, 20070201
  40. Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress., Journal of Neurochemistry, 96, 1090-1100, 20060901
  41. Autophagy is activated for cell survival after endoplasmic reticulum stress., Molecular and Cellular Biology, 26, 9220-9231, 20060101
  42. Candidates for tumor-specific alternative splicing., Biochemical and Biophysical Research Communications, 334, 23-29, 20050801
  43. ★, XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress., Biochemical and Biophysical Research Communications, 331, 1146-1153, 20050501
  44. OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes., Nature Cell Biology, 7, 186-194, 20050201
  45. Identification of regulatory cis-acting elements for alternative splicing of presenilin-2 exon 5 under hypoxic stress conditions., Journal of Neurochemistry, 91, 1191-1198, 20040901