SOSHI KANEMOTO
Last Updated :2025/02/04
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
- E-mail
- soshi-kanemoto
hiroshima-u.ac.jp
Basic Information
Academic Degrees
- Doctor of Philosophy, Nara Institute of Science and Technology
- Master, Kyoto University
Research Fields
- Medicine,dentistry, and pharmacy;Basic medicine;General medical chemistry
- Biological Sciences;Neuroscience;Neurochemistry / Neuropharmacology
- Biology;Biological Science;Molecular biology
- Medicine,dentistry, and pharmacy;Clinical surgery;Orthopaedic surgery
Research Keywords
Research Activities
Academic Papers
- Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis, COMMUNICATIONS BIOLOGY, 5(1), 20220722
- Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis, FASEB JOURNAL, 35(2), 202102
- NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 2019
- Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9, 2018
- Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
- Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
- Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
- ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 201709
- Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
- The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 20161117
- Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 20160803
- The physiological roles of ER stress transducer BBF2H7/CREB3L2 and its potential as a target of disease therapy., Medical Research Archives
- ★, Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
- IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 20151116
- OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 20151112
- Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), 20150508
- Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 13810-13820, 20140516
- ★, PROLIFERATION, DIFFERENTIATION AND AMYLOID-beta PRODUCTION IN NEURAL PROGENITOR CELLS ISOLATED FROM TGCRND8 MICE, NEUROSCIENCE, 261, 52-59, 20140307
- Increased Susceptibility to Dextran Sulfate Sodium-Induced Colitis in the Endoplasmic Reticulum Stress Transducer OASIS Deficient Mice, PLOS ONE, 9(2), 20140203
- Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2, MOLECULAR CELL, 53(1), 127-139, 201401
- Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells, PLOS ONE, 8(1), 20130130
- Activation of OASIS family, ER stress transducers, is dependent on its stabilization, CELL DEATH AND DIFFERENTIATION, 19(12), 1939-1949, 201212
- Roles of Endoplasmic Reticulum Stress in Neurodegenerative Diseases., Translational Medicine, 2, e108, 20120101
- Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue, SCIENTIFIC REPORTS, 2, 20121112
- The Endoplasmic Reticulum Stress Transducer BBF2H7 Suppresses Apoptosis by Activating the ATF5-MCL1 Pathway in Growth Plate Cartilage, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(43), 36190-36200, 20121019
- Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation, NATURE COMMUNICATIONS, 3, 201207
- The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(11), 8144-8153, 20120309
- The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology, JOURNAL OF BIOCHEMISTRY, 149(5), 507-518, 201105
- Physiological unfolded protein response regulated by OASIS family members, transmembrane bZIP transcription factors, IUBMB LIFE, 63(4), 233-239, 201104
- Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis., Journal of Bone and Mineral Metabolism, 28, 131-138, 20100301
- Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis., Nature Cell Biology, 11, 1197-1204, 20091201
- Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation., Nature Cell Biology, 11, 1205-1211, 20091201
- TMP21 transmembrane domain regulates gamma-secretase cleavage., The Journal of Biological Chemistory, 284, 28634-28641, 20091001
- APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes., The Journal of Biological Chemistory, 284, 16298-16307, 20090401
- ★, A molecular chaperone inducer protects neurons from ER stress., Cell Death & Differentiation, 15, 364-375, 20080301
- Molecular mechanisms responsible for aberrant splicing of SERCA1 in myotonic dystrophy type1., Human Molecular Genetics, 16, 2834-2843, 20071001
- Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle., Acta Neuropathologica, 114, 527-535, 20071001
- BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer., Molecular and Cellular Biology, 27, 1716-1729, 20070201
- Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress., Journal of Neurochemistry, 96, 1090-1100, 20060901
- Autophagy is activated for cell survival after endoplasmic reticulum stress., Molecular and Cellular Biology, 26, 9220-9231, 20060101
- Candidates for tumor-specific alternative splicing., Biochemical and Biophysical Research Communications, 334, 23-29, 20050801
- ★, XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress., Biochemical and Biophysical Research Communications, 331, 1146-1153, 20050501
- OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes., Nature Cell Biology, 7, 186-194, 20050201
- Identification of regulatory cis-acting elements for alternative splicing of presenilin-2 exon 5 under hypoxic stress conditions., Journal of Neurochemistry, 91, 1191-1198, 20040901