DAISUKE ISHII

Last Updated :2026/06/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
Web Site
https://cbn-lab.hiroshima-u.ac.jp/
E-mail
ishiidhiroshima-u.ac.jp
Self-introduction
I am exploring novel approaches to promote functional recovery after stroke. My current research focuses on identifying new therapeutic agents using a mouse model of unilateral spatial neglect and developing effective interventions for sensory impairments caused by stroke. These studies aim to elucidate the mechanisms of recovery and contribute to the development of innovative rehabilitation strategies.

Basic Information

Major Professional Backgrounds

  • 2025/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Professor
  • 2022/04, 2025/03, Ibaraki Prefectural University of Health Sciences, Department of Occupational Therapy, School of Health Sciences, Associate Professor
  • 2017/10, 2022/03, Ibaraki Prefectural University of Health Sciences, Center of Medical Science, School of Health Sciences, Assistant Professor
  • 2017/04, 2017/09, International University of Health and Welfare, Department of Occupational Therapy, School of Health Sciences, Assistant Professor
  • 2013/04, 2017/01, Kisarazu Hospital, Occupational Therapist
  • 2008/04, 2013/03, Syuubien, Geriatric Health Services Facility, Occupational Therapist

Educational Backgrounds

  • Chiba University, Graduate School of Medical and Pharmaceutical Sciences, Japan, 2010/04, 2013/03
  • Chiba University, Department of Medical Sciences, Graduate School of Medical and Pharmaceutical Sciences, Japan, 2008/04, 2010/03
  • Showa University, School of Nursing and Rehabilitation Sciences, Department of Occupational Therapy, 2004/04, 2008/03

Academic Degrees

  • Chiba University
  • Chiba University

Research Fields

  • Complex systems;Biomedical engineering;Rehabilitation science / Welfare engineering
  • Medicine,dentistry, and pharmacy;Basic medicine;General physiology

Research Keywords

  • Mouse model of unilateral spatial neglect, Rat model of thalamic hemorrhage, Behavioral experiment, Somatosensory, Electrophysiology, Somatosensory evoked potential (SEP), Fear memory

Affiliated Academic Societies

  • The Japan Neuroscience Society
  • The Physiological Society of Japan
  • Japanese Society of Occupational Therapy Research
  • Japanese Society for Brain Function and Rehabilitation
  • Japanese Association of Occupational Therapists

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, 4Term, Ethics & Management
  2. 2026, Undergraduate Education, Intensive, Clinical practice I
  3. 2026, Undergraduate Education, Intensive, Clinical practice II
  4. 2026, Undergraduate Education, 3Term, Preliminary Research Practice
  5. 2026, Undergraduate Education, Second Semester, Practice of occupational therapy assessment for physical dysfunction I
  6. 2026, Undergraduate Education, First Semester, Seminar of higher brain dysfunction I
  7. 2026, Graduate Education (Master's Program) , 2Term, Multidisciplinary Cooperation A
  8. 2026, Graduate Education (Doctoral Program) , 2Term, Multidisciplinary Cooperation B
  9. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
  10. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
  11. 2026, Graduate Education (Master's Program) , First Semester, Lecture on Cognitive and Behavioral Neuroscience
  12. 2026, Graduate Education (Master's Program) , First Semester, Seminar on Cognitive and Behavioral Neuroscience
  13. 2026, Graduate Education (Master's Program) , Second Semester, Seminar on Cognitive and Behavioral Neuroscience
  14. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Cognitive and Behavioral Neuroscience
  15. 2026, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cognitive and Behavioral Neuroscience
  16. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cognitive and Behavioral Neuroscience
  17. 2026, Graduate Education (Master's Program) , First Semester, Research on Cognitive and Behavioral Neuroscience
  18. 2026, Graduate Education (Master's Program) , Second Semester, Research on Cognitive and Behavioral Neuroscience

Research Activities

Academic Papers

  1. Role of the Medial Agranular Cortex in Sensory-Motor Integration During Walking: Insights From a Rodent Stroke Model, Cureus, 20251113
  2. Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus, Genes, Brain and Behavior, 14(3), 301-309, 20250527
  3. Enhanced flavoprotein autofluorescence imaging in rats using a combination of thin skull window and skull-clearing reagents, Neuroscience Letters, 20250329
    Link to Paper Search Results by DOI
  4. Prolonged cortical silent period of the cervical muscle in American college football players with sports-related concussions, The Journal of Physical Fitness and Sports Medicine, 15(5), 202507
  5. A Transient Fear Reduction by Pair-Exposure with a Non-Fearful Partner during Fear Extinction Independent from Corticosterone Level in Mice, Journal of Behavioral and Brain Science, 3(5), 415-421, 2013
  6. Age-Related Impact in Illusory Torque Cues Induced by Asymmetric Vibrations, IEEE TRANSACTIONS ON HAPTICS, 18(3), 498-506, 2025
    Link to Paper Search Results by DOI
  7. Case Report: Repetitive peripheral magnetic stimulation and task-oriented training improve motor function in chronic severe post-stroke paralysis, Frontiers in Stroke, 4, 2025
  8. Factors associated with stiff knee gait in patients with knee osteoarthritis., Journal of orthopaedics, 64, 2025
  9. ★, The rodent model of unilateral spatial neglect and its clinical applications, Journal of Rehabilitation Neurosciences, 24, 2024
  10. ★, Role of the medial agranular cortex in unilateral spatial neglect., Experimental brain research, 242(6), 2024
  11. Decreased and Improved Movement Abilities in a Case of Myotonic Dystrophy Type 1: Examining Longitudinal Characteristics Based on Repeated Evaluations., Cureus, 16(5), 2024
  12. Combined Exercise and Education Program: Effect of Smaller Group Size and Longer Duration on Physical Function and Social Engagement among Community-Dwelling Older Adults, The Journal of Aging Research & Lifestyle, 12, 2023
  13. Asymmetry of Interhemispheric Connectivity during Rapid Movements of Right and Left Hands: A TMS-EEG Study., Journal of motor behavior, 54(2), 2022
  14. Effects of short-term upper limb immobilization on sensory information processing and corticospinal excitability., Experimental brain research, 240(7-8), 2022
  15. Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex Modulates Cognitive Function Related to Motor Execution During Sequential Task: A Randomized Control Study., Frontiers in human neuroscience, 16, 2022
  16. Effects of medication and dual tasking on postural sway in Parkinson's disease: A pilot case study, Advanced Robotics, 35, 2021
  17. Opposite modulations of corticospinal excitability by intermittent and continuous peripheral electrical stimulation in healthy subjects., Neuroscience letters, 740, 2021
  18. ★, Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex: A mouse model of unilateral spatial neglect., Behavioural brain research, 401, 2021
  19. A study on the immediate effects of neuromuscular electrical stimulation on the corticospinal tract excitability of the infraspinatus muscle., Journal of back and musculoskeletal rehabilitation, 34(4), 2021
  20. Experience of After-Effect of Memory Update Reduces Sensitivity to Errors During Sensory-Motor Adaptation Task., Frontiers in human neuroscience, 15, 2021
  21. Relationship Between Motor Function, DTI, and Neurophysiological Parameters in Patients with Stroke in the Recovery Rehabilitation unit., Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 30(8), 2021
  22. ★, Contralateral and Ipsilateral Interactions in the Somatosensory Pathway in Healthy Humans., Frontiers in systems neuroscience, 15, 2021
  23. The Progress of the Gait Impairment and Brain Activation in a Patient with Post-stroke Hemidystonia., Physical therapy research, 24(2), 2021
  24. Gait Training after Stroke with a Wearable Robotic Device: A Case Report of Further Improvements in Walking Ability after a Recovery Plateau., Progress in rehabilitation medicine, 6, 2021
  25. ★, Interaction of the Left-Right Somatosensory Pathways in Patients With Thalamic Hemorrhage: A Case Report., Frontiers in human neuroscience, 15, 2021
  26. Cathodal tDCS on the motor area decreases the tactile threshold of the distal pulp of the hallux., Neuroscience letters, 719, 2020
  27. A Short-Duration Combined Exercise and Education Program to Improve Physical Function and Social Engagement in Community-Dwelling Elderly Adults., International quarterly of community health education, 40(4), 2020
  28. Successful transcatheter arterial embolization in an asymptomatic patient with primary racemose hemangioma of the bronchial artery., Respiratory medicine case reports, 30, 2020
  29. Spondylodiscitis and spinal epidural abscess related to long-term placement of an airway stent for malignant central airway obstruction., Thoracic cancer, 11(8), 2020
  30. Spontaneous recovery of fear differs among early - late adolescent and adult male mice., The International journal of neuroscience, 129(1), 2019
  31. Paternal methyl donor deficient diets during development affect male offspring behavior and memory-related gene expression in mice., Developmental psychobiology, 61(1), 2019
  32. Effect of Visuospatial Attention on the Sensorimotor Gating System., Frontiers in behavioral neuroscience, 13, 2019
  33. Cued and contextual fear memories are erased by a long passage of time after fear conditioning, Chiba Medical Journal, 94(5), 45-50, 2018
  34. Development of the fear regulation system from early adolescence to young adulthood in female mice., Neurobiology of learning and memory, 150, 2018
  35. Differential effects of high-definition transcranial direct current stimulation on verbal working memory performance according to sensory modality., Neuroscience letters, 687, 2018
  36. Transient contribution of left posterior parietal cortex to cognitive restructuring., Scientific reports, 5, 2015
  37. An isolated retrieval trial before extinction session does not prevent the return of fear., Behavioural brain research, 287, 2015
  38. Sex differences in fear extinction and involvements of extracellular signal-regulated kinase (ERK)., Neurobiology of learning and memory, 123, 2015
  39. Longitudinal Follow-Up of Mirror Movements after Stroke: A Case Study., Case reports in neurological medicine, 2015, 2015
  40. Effects of memory age and interval of fear extinction sessions on contextual fear extinction., Neuroscience letters, 578, 2014
  41. Methyl donor-deficient diet during development can affect fear and anxiety in adulthood in C57BL/6J mice., PloS one, 9(8), 2014
  42. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice., Hormones and behavior, 63(5), 2013
  43. No erasure effect of retrieval-extinction trial on fear memory in the hippocampus-independent and dependent paradigms., Neuroscience letters, 523(1), 2012
  44. Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain., Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 2012
  45. Enhancement of acoustic prepulse inhibition by contextual fear conditioning in mice is maintained even after contextual fear extinction., Progress in neuro-psychopharmacology & biological psychiatry, 34(1), 2010
  46. Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway., Neuroscience letters, 471(1), 2010
  47. d-serine enhances extinction of auditory cued fear conditioning via ERK1/2 phosphorylation in mice., Progress in neuro-psychopharmacology & biological psychiatry, 34(6), 2010

Invited Lecture, Oral Presentation, Poster Presentation

  1. A mouse model of unilateral spatial neglect: Implications for rehabilitation research, 2026/03/12, Without Invitation, English
  2. Dynamic Contralesional Motor Map Plasticity Reveals Adaptive and Maladaptive Phases in Mouse Recovery from Primary Motor Cortex Stroke, Hironobu Osaki, Daisuke Ishii, and Yoshito Masamizu, 2026/03/12, Without Invitation, English
  3. Repetitive peripheral magnetic stimulation and task-oriented training improve motor function in chronic severe post-stroke paralysis: a case study, Yamamoto, Aoyama T, Ishii D, Ishibashi K, Kohno Y, KMU IPUHS Overseas Exchange Program, 2025/03/21, Without Invitation, English
  4. Establishment of an aged mouse model of unilateral spatial neglect and the impact of aging on symptom severity, Daisuke Ishii, Hironobu Osaki, Atsuko Uchida, Satoshi Yamamoto, Yutaka Kohno, FENS Forum 2024, 2024/06/25, Without Invitation, English
  5. Ipsilesional spatial bias after a focal cerebral infarction in the medial agranular cortex and posterior parietal cortex, Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno, 2023/03/15, Without Invitation, English
  6. A mouse model of unilateral spatial neglect, Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Satoshi Yamamoto, Mariko Miyata, Yutaka Kohno, International Symposium on Hyper-Adaptability HypAd 2021, 2021/05/27, Without Invitation, English
  7. AppropriEne MRI acquisition parameters to analyze functional connectivity in resting state motor networks with a 1.5 T scanner, Satoshi Yamamoto, Daisuke Ishii, Hiroshi Kawaguchi, Toru Yamada, Keiji Matsuda, Takayuki Iwano, Yoshihiro Fujii, Masahiko Monma, Yutaka Kohno, FENS 2020 Virtual Forumm, 2020/07/11, Without Invitation, English
  8. Role of the right frontal orienting field in visuospatial attention, Daisuke Ishii, Hironobu Osaki, Arito Yozu, Kiyoshige Ishibashi, Kenta Kawamura, Mariko Miyata, Yutaka Kohno, The 97th Annual Meeting of the Physiological Society of Japan, 2020/03/17, Without Invitation, English
  9. Afferent pathway to the ipsilateral somatosensory cortex in human, Daisuke Ishii, Kiyoshige Ishibashi, Yuki Kaku, Hiroshi Yuine, Satoshi Yamamoto, Arito Yozu, Yutaka Kohno, Neuroscience 2019, 2019/10/19, Without Invitation, English
  10. Laterality effects of the visual information processing on the sensorimotor gating system, Daisuke Ishii, Kotaro Takeda, Satoshi Yamamoto, Akira Noguchi, Kiyoshige Ishibashi, Kenya Tanamachi, Arito Yozu, Yutaka Kohno, The 9th Federation of Asian and Oceanian Physiological Societies Congress: FAOPS 2019, 2019/03/28, Without Invitation, English
  11. Laterality effects of the visual information processing on the sensorimotor gating system, Daisuke Ishii, Kotaro Takeda, Satoshi Yamamoto, Akira Noguchi, Kiyoshige Ishibashi, Kenya Tanamachi, Arito Yozu, Yutaka Kohno, The 9th Federation of the Asian and Oceanian Physiological Societies Congress, 2019/03/28, Without Invitation, English
  12. The laterality of the visual information processing, Daisuke Ishii, Kotaro Takeda, Satoshi Yamamoto, Akira Noguchi, Kiyoshige Ishibashi, Kenya Tanamachi, Arito Yozu, Yutaka Kohno, The 2nd International Symposium on Embodied-Brain Systems Science, 2018/12/06, Without Invitation, English
  13. Effects of cathodal tDCS on motor area on tactile threshold of the distal pulp of the hallux, Daisuke Ishii, Satoshi Yamamoto, Arito Yozu, Yutaka Kohno, Neuroscience 2018, 2018/11/03, Without Invitation, English
  14. Effects of adult ovariectomy on fear extinction and recovery, NEURO2026, 2013/06/22, Without Invitation, English
  15. Long-term methyl donors deficit impairs long-term memory, NEURO2026, 2013/06/22, Without Invitation, English
  16. Effect of brain development during adolescence on spontaneous recovery of contextual fear memory, NEURO2026, 2013/06/22, Without Invitation, English
  17. A dynamic fMRI study of restructuring cognitive schema for dirtiness, Chihiro Sutoh, Daisuke Matsuzawa, Yoshiyuki Hirano, Sudesna Chakraborty, Daisuke Ishii, Shingo Matsuda, Haruna Tomizawa, Takayuki Obata, Eiji Shimizu, Neuroscience 2012, 2012/10/13, Without Invitation, English
  18. Effects of methyl donors deficient diet on cognitive functions, Haruna Tomizawa, Daisuke Matsuzawa, Daisuke Ishii, Shingo Matsuda, Chihiro Sutoh, Eiji Shimizu, Neuroscience 2012, 2012/10/13, Without Invitation, English
  19. Sex differences in fear extinction under isolation stress, Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Chihiro Sutoh, Eiji Shimizu, Neuroscience 2012, 2012/10/13, Without Invitation, English
  20. Effect of brain development during adolescence on recovery of fear, Daisuke Ishii, Daisuke Matsuzawa, Shingo Matsuda, Haruna Tomizawa, Chihiro Sutoh, Eiji Shimizu, Neuroscience 2012, 2012/10/13, Without Invitation, English
  21. No erasure effect of retrieval-extinction trial on fear memory, Neuroscience 2012, 2012/09/18, Without Invitation, English
  22. Sex differences in effect of repeated fear extinction, Neuroscience 2012, 2012/09/18, Without Invitation, English
  23. Effects of non-fearful partner on fear extinction memory and corticosterone level, Neuroscience 2012, 2012/09/18, Without Invitation, English
  24. The sex differences in spontaneous recovery of fear memory, Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Eiji Shimizu, Neuroscience 2011, 2011/11/12, Without Invitation, English
  25. Persistent fear relief effect of social buffering in fear conditioned mice, Haruna Tomizawa, Daisuke Matsuzawa, Daisuke Ishii, Shingo Matsuda, Eiji Shimizu, Neuroscience 2011, 2011/11/12, Without Invitation, English
  26. Erasure effects of an isolated retrieval trial on fear memory in hippocampus–dependent fear renewal paradigm, Daisuke Ishii, Daisuke Matsuzawa, Shingo Matsuda, Haruna Tomizawa, Chihiro Sutoh, Ken Nakazawa, Eiji Shimizu, Neuroscience 2011, 2011/11/12, Without Invitation, English
  27. Methyl donor deficient diet during the developmental period changes gene expressions patterns of NMDA receptor subtypes in adults, Neuroscience 2011, 2011/09/16, Without Invitation, English
  28. The sex differences in recovery of fear memory, Neuroscience 2011, 2011/09/16, Without Invitation, English
  29. Effects of perinatal exposure to low dose of bisphenol A on anxiety behavior, monoamines, and activity of MAO in the male mice, Shingo Matsuda, Chihiro Sutoh, Daisuke Ishii, Haruna Tomizawa, Daisuke Matsuzawa, Ken Nakazawa, Eiji Shimizu, Neuroscience 2010, 2010/11/13, Without Invitation, English
  30. Effects of methionine, choline and folic acid- deficient diet at the developmental period on anxiety and fear in mice, Daisuke Ishii, Daisuke Matsuzawa, Chihiro Sutoh, Shingo Matsuda, Haruna Tomizawa, Eiji Shimizu,, Neuroscience 2010, 2010/11/13, Without Invitation, English
  31. Developmental effects of one-carbon nutrients-deficient diet on anxiety and fear, Neuro2010, 2010/09/02, Without Invitation, English
  32. Effects of perinatal low BPA on monoamines and MAO in the brain of mice, Neuro2010, 2010/09/02, Without Invitation, English
  33. Comprehensive quantitative gene expression analysis in the process of mouse fear conditioning, Neuro2010, 2010/09/02, Without Invitation, English
  34. Enhancement of prepulse inhibition by fear conditioning in mice, Neuroscience 2009, 2009/09/16, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. Grants-in-Aid for Scientific Research, Establishment of a mouse model of unilateral spatial neglect, 2018, 2021
  2. Grants-in-Aid for Scientific Research, Effect of luteolin on long-term neurological damage in a mouse model of postresuscitation encephalopathy, 2020, 2024
  3. Grants-in-Aid for Scientific Research, Identification of a novel compound promoting recovery from Unilateral Spatial Neglect beyond the critical period, 2022, 2025
  4. Grants-in-Aid for Scientific Research, In Preparation, 2023, 2025
  5. Grants-in-Aid for Scientific Research, In Preparation, 2023, 2025
  6. Grants-in-Aid for Scientific Research, Research for a science-based rehabilitation program in Parkinson's disease, 2023, 2027
  7. Grants-in-Aid for Scientific Research, Reorganization of Sensory Input Pathways After Stroke and Development of Novel Interventions, 2021, 2024