Makoto Sugita

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Professor
Web Site
https://oralphysiology.wixsite.com/hiroshima
E-mail
sugisanhiroshima-u.ac.jp
Self-introduction
I am very interested in the mechanisms underlying taste-evoked emotional and behavioral responses, and also in the molecular and cellular mechanisms of ion and fluid secretion from salivary glands.

Basic Information

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry

Research Keywords

  • taste
  • taste perception
  • emotional memory
  • neuronal circuitry
  • salivary secretion
  • CFTR

Affiliated Academic Societies

  • The Physiological Society for Japan
  • Japanese Association for Oral Biology
  • The Hiroshima University Dental Society
  • The Molecular Biology Society of Japan
  • The Japanese Association for the Study of Taste and Smell

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 1Term, Foundation biology for life science
  2. 2024, Undergraduate Education, 4Term, Life Science
  3. 2024, Undergraduate Education, 1Term, Oral Physiology I
  4. 2024, Undergraduate Education, 2Term, Oral Physiology II
  5. 2024, Undergraduate Education, 3Term, Practice of Oral Physiology
  6. 2024, Undergraduate Education, 4Term, Research Start-Up
  7. 2024, Undergraduate Education, 1Term, Topics in Dental Research I
  8. 2024, Undergraduate Education, 3Term, Endodontics I
  9. 2024, Undergraduate Education, 4Term, Endodontics II
  10. 2024, Undergraduate Education, 3Term, Stomatognathic Function
  11. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  12. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  13. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  14. 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
  15. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  16. 2024, Undergraduate Education, 4Term, Physiology and Oral Physiology
  17. 2024, Undergraduate Education, Second Semester, Practice on Basic Dental Sciences
  18. 2024, Undergraduate Education, 4Term, Research Start-Up
  19. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  20. 2024, Undergraduate Education, 4Term, Physiology and Oral Physiology
  21. 2024, Undergraduate Education, 4Term, Research Start-Up
  22. 2024, Undergraduate Education, 2Term, Lifestyle-related Dentistry and Geriatric Dentistry
  23. 2024, Graduate Education (Master's Program) , First Semester, Seminar
  24. 2024, Graduate Education (Master's Program) , Second Semester, Seminar
  25. 2024, Graduate Education (Master's Program) , First Semester, Research
  26. 2024, Graduate Education (Master's Program) , Second Semester, Research
  27. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  28. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  29. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  30. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  31. 2024, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  32. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Physiology and Oral Physiology
  33. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Physiology and Oral Physiology
  34. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Physiology and Oral Physiology
  35. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Physiology and Oral Physiology

Research Activities

Academic Papers

  1. Resting Saliva Volume as a Risk Factor for Hypogeusia: A Retrospective Study, Physiology & Behavior, 267, 114224, 202305
  2. Effect of irinotecan administration on amiloride-sensitive sodium taste responses in mice, EUROPEAN JOURNAL OF ORAL SCIENCES, 131(2), 202304
    Link to Paper Search Results by DOI
  3. Characterization of the fatty acid profile in the ventral midbrain of mice exposed to dietary imbalance between omega-6 and omega-3 fatty acids during specific life stages, BMC RESEARCH NOTES, 15(1), 20220905
    Link to Paper Search Results by DOI
  4. Suppression of carbachol-induced oscillatory Cl- secretion by forskolin in rat parotid and submandibular acinar cells, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 294(3), G738-G747, 200803
    Link to Paper Search Results by DOI
  5. Involvement of cytoskeletal integrity in the regulation of Cl(-) and amylase secretion from rat parotid acinar cells, BIOMEDICAL RESEARCH-TOKYO, 29(3), 131-139, 200807
    Link to Paper Search Results by DOI
  6. ★, INFORMATION PROCESSING IN BRAINSTEM BITTER TASTE-RELAYING NEURONS DEFINED BY GENETIC TRACING, NEUROSCIENCE, 250, 166-180, 20131010
    Link to Paper Search Results by DOI
  7. Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells, J. Membrane Biol, 180(1), 11-19, 20010301
  8. Potentiation by isoproterenol on carbachol-induced K+ and Cl- currents and fluid secretion in rat parotid., J Membr Biol, 164(2), 197-203, 19980701
  9. External Cl-Dependent Formation of Watery Vacuoles by Long-Term Hypotonic Shock in 3T3-L1 Cells, Cellular Physiology and Biochemistry, １１, impress, 20010401
  10. ★, Visualization of the secretory process involved in Ca2+-activated fluid secretion from rat submandibular glands using the fluorescent dye, calcein., Eur. J. Cell Biol., 79, 182-191, 20000401
  11. cAMP-dependent ptentiation of the Ca2+-activated release of the anionic fluorescent dye, calcein, from rat parotid acinar cells., Eur. J. Pharmacol., 388, 227-234, 20000401
  12. High-efficiency transfer of cystic fibrosis transmembrane conductance regulator cDNA into cystic fibrosis airway cells in culture using lactosylated polylysine as a vector., Hum Gene Ther, 10, 615-622, 19990401
  13. ★, CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates., EMBO J., 17, 898-908, 19980401
  14. ★, Involvement of intracellular calcium ions in the release of the fluorescent dye calcein by cholinergic and a-adrenergic agonists from rat parotid acinar cells., Pflugers Arch, 429, 555-560, 19950401
  15. carbachol-induced fluid movement through methazolamide-sensitive bicharbonate production in rat paratid intracbular ducts:Quantative analysis of fluorescence images using fluorescent dye sulforhodamine under a confocal laser scanning microasope, Eur. J. Cell Biol., 81, 497-504, 20020401
  16. Evaluation of mastication-induced change in sympatho-vagal balance through spectral analysis of heart rate variability, J Oral Rehabil, 29, 956-960, 20020401
  17. Forskolin-induced clearance of the fluorescent dye sulforhodamine from rat paratid intraloblur duct lumen:Visualization of the secretory function under a confocal laser scannning microscope, J Membr Biol, 190, 189-196, 20020401
  18. Extracellular proton sensing of the rat gustatory cyclic nucleotide-gated channel, Biochem. Biophys. Res. Commun., 319, 369-374, 20040401
  19. ★, Gramicidin-perforated patch recording revealed the oscillatory nature of secretory Cl- movements in salivary acinar cells, J. Gen. Physiol., 124, 59-69, 20040401
  20. Molecular dissection of the butyrate action revealed the involvement of mitogen-activated protein kinase in cystic fibrosis transmembrane conductance regulator biogenesis, Mol Pharmacol, 66, 1248-1259, 20040401
  21. ★, Genetic tracing shows segregation of taste neuronal circuitries for bitter and sweet, Science, 309, 781-785, 20050701
  22. Taste perception and coding in the periphery, Cell. Mol. Life Sci., 63, 2000-2015, 20060901
  23. Membrane potential modulation of ionomycin-stimulated Ca(2+) entry via Ca (2+)/H (+) exchange and SOC in rat submandibular acinar cells., The Journal of Physiological Sciences, 60(5), 363-371, 20100901
  24. Functional dissection of sweet and bitter taste pathways, Journal of Oral Bioscience, 55, 66-72, 20130501
  25. Role of mastication and swallowing in the control of autonomic nervous activity for heart rate in different postures, JOURNAL OF ORAL REHABILITATION, 30(12), 1209-1215, 200312
    Link to Paper Search Results by DOI
  26. TMEM16E (GDD1) Exhibits Protein Instability and Distinct Characteristics in Chloride Channel/Pore Forming Ability, JOURNAL OF CELLULAR PHYSIOLOGY, 229(2), 181-190, 201402
    Link to Paper Search Results by DOI
  27. Different rate-limiting activities of intracellular pH regulators for HCO3 (-) secretion stimulated by forskolin and carbachol in rat parotid intralobular ducts, JOURNAL OF PHYSIOLOGICAL SCIENCES, 66(6), 477-490, 201611
    Link to Paper Search Results by DOI
  28. The biphasic effect of extracellular glucose concentration on carbachol-induced fluid secretion from mouse submandibular glands, EUROPEAN JOURNAL OF ORAL SCIENCES, 126(3), 197-205, 201806
    Link to Paper Search Results by DOI
  29. The activity of Na+-K+-2Cl- cotransporter for salivary Cl- secretion revealed by gramicidin-perforated patch recording, The Journal of Hiroshima University Dental Society, 50(1), 9-14, 201806

Invited Lecture, Oral Presentation, Poster Presentation

  1. The architecture and information processing in brainstem bitter taste-relaying neurons defined by genetic tracing, Sugita M., Yamamoto K., Hirono C., Shiba Y., 17th International Symposium on Olfaction and Taste, 2016/06/08, Without Invitation, English, ISOT, Yokohama
  2. The rate-limiting activities for anion secretion from acinar and duct cells in salivary glands, Sugita M, Ueno K, Kitagawa M, Shiba Y, Hirono C, The 59th Annual Meeting of Japanese Association for Oral Biology, 2017/09/16, Without Invitation, Japanese, Japanese Association for Oral Biology, Matsumoto
  3. The biphasic effect of extracellular glucose concentration on salivary fluid secretion, Terachi M, Hirono C, Kitagawa M, Sugita M, 2017 NIPS Research Meeting, 2017/09/07, Without Invitation, Japanese, Okazaki
  4. Taste aversion learning induces plastic changes in amygdalar neurons defined by genetic tracing of taste representation, Chang C-M, Takemoto T, Sugita M, The 51th Annual Meeting of Hiroshima University Dental Society, 2018/06/09, Without Invitation, English, Hiroshima
  5. Information processing of attractive and aversive salt tastes in brainstem neurons, Yamamoto K, Sugita M, 2018 NIPS Research Meeting, 2018/09/07, Without Invitation, Japanese, Okazaki
  6. The rate-limiting activities for Cl- secretion from salivary acinar cells with their dependency on extracellular glucose concentration, Sugita M., Terachi M., Kitagawa M., Hirono C., The 70th Annual Meeting of the PSJ Chugoku-Shikoku Division, 2018/10/28, Without Invitation, Japanese, The physiological Society of Japan, Toon
  7. Information processing in brainstem bitter taste-relaying neurons, Sugita M., Yamamoto K., The 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2019), 2019/03/29, Without Invitation, English, Federation of the Asian and Oceanian Physiological Societies, Kobe
  8. Involvement of sodium-glucose cotransporter activity in sustaining Cl- and fluid secretion from salivary glands, Sugita M., Takeyasu M., Murakami T., Terachi M., Kozai K., 2019 NIPS Research Meeting, 2019/09/06, Without Invitation, Japanese, Okazaki
  9. Effect of extracellular glucose concentration on carbachol-induced fluid secretion from submandibular glands, Sugita M., Kitagawa M., The 61th Annual Meeting of Japanese Association for Oral Biology, 2019/10/14, Without Invitation, Japanese, Tokyo
  10. The role of sodium-glucose cotransporter-1 in maintaining Cl- secretion that drives fluid secretion from salivary glands, Sugita M., Takeyasu M., Terachi M., Kozai K., 2020 NIPS Research Meeting, 2020/09/04, Without Invitation, Japanese, Okazaki
  11. Genetic tracing-based characterization of bitter-taste relaying neurons in the parabrachial nuclei, Sugita M, The 62th Annual Meeting of Japanese Association for Oral Biology, 2020/09/27, Without Invitation, Japanese, Kagoshima
  12. The roles of brain polyunsaturated fatty acids in dopamine-dependent ingestive behaviors, Nobuyuki Sakayori, Masanori Katakura, Makoto Sugita, Kazuto Kobayashi, The 44th Annual Meeting of the Japan Neuroscience Society, 2021/07/31, Without Invitation, English, The Japan Neuroscience Society, Kobe
  13. Gramicidin-perforated patch recording reveals the involvement of SGLT1 activities in maintaining Cl- secretion from submandibular acinar cells, Sugita M, The 63th Annual Meeting of Japanese Association for Oral Biology, 2021/10/11, Without Invitation, English, Japanese Association for Oral Biology, Online
  14. Plastic changes in activities of bitter taste-relaying neurons in the medial amygdala during conditioned taste aversion learning, Sugita M, Chang C-M, The 99th Annual Meeting of the Physiological Society of Japan, 2022/03/18, Without Invitation, English, The Physiological Society of Japan, Sendai
  15. Dietary polyunsaturated fatty acids during pregnancy regulate dopaminergic neurogenesis in their embryos and are associated with offspring's various behavioral abnormalities, Sakayori N, Fujii K, Katakura M, Kobayashi K, Takao K, Sugita M, NEURO2022, 2022/07/01, Without Invitation, English, The Japan Neuroscience Society, Okinawa-Online
  16. Genetic tracing reveals bitter taste-relaying neurons in the medial amygdala change their responses to sweet stimuli after conditioned taste aversion learning, Sugita M, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/19, Without Invitation, English, Japanese Association for Oral Biology, Tokushima
  17. Wasabi sulfinyl derivative 6-MSITC promotes mineralization efficiency of human odontoblasts, Furusawa Y, Kimura M, Ouchi T, Okunishi I, Kato-Yamada T, Sugita M, Shibukawa Y, Furusawa M, The 64th Annual Meeting of Japanese Association for Oral Biology, 2022/09/17, Without Invitation, English, Japanese Association for Oral Biology, Tokushima
  18. Comprehensive behavioral analyses of male and female mice derived from mothers fed a diet high in omega-6 and low in omega-3 fatty acids, Sakayori N, Fujii K, Katakura M, Takao K, Sugita M, 22nd IUNS International Congress of Nutrition, 2022/12/11, Without Invitation, English, Tokyo
  19. Functional characterization of bitter taste-relaying neurons in the parabrachial nuclei, Sugita, Makoto; Yamamoto, Kuniyo, 2023/03/16, Without Invitation, English, Kyoto
  20. Mineralization-Promoting Ability of Hexaraphane® in Human Odontoblasts, Yoshiaki Furusawa, Maki Kimura, Isao Okunishi, Takehito Ouchi, Tomoe Kato-Yamada, Ryuya Kurashima, Makoto Sugita, Yoshiyuki Shibukawa, Masahiro Furusawa, 2023 AADOCR/CADR Annual Meeting & Exhibition, 2023/03/15, Without Invitation, English, Portland, USA

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2018, 2020
  2. KAKENHI, 2012, 2014
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  3. KAKENHI, The study on neuronal bases of taste cognition in gustatory neurons defined by genetic tracing, 2009, 2011
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  4. 2006
  5. KAKENHI, 2006, 2007
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  6. KAKENHI, Genetic approach to trace construction of taste neuronal circuitries, 2005, 2006
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  7. KAKENHI, 2003, 2004
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  8. KAKENHI, 2001, 2002
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  9. KAKENHI, 2000, 2001
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  10. KAKENHI, 1999, 2000
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  11. KAKENHI, 1995, 1995
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Social Activities

History as Peer Reviews of Academic Papers

  1. 2016, The Journal of Hiroshima University Dental Society, Chief editor
  2. 2017, The Journal of Hiroshima University Dental Society, Chief editor