Kouichi Funato
Last Updated :2021/02/01
- Affiliations, Positions
- Graduate School of Integrated Sciences for Life, Associate Professor
- E-mail
- kfunato
hiroshima-u.ac.jp
Basic Information
Academic Degrees
- Doctor of Philosophy in Pharmaceutical Science, The University of Tokushima
- Master of Pharmaceutical Science, The University of Tokushima
Research Fields
- Agricultural sciences;Agricultural chemistry;Applied microbiology
- Agricultural sciences;Agricultural chemistry;Applied biochemistry
Research Keywords
- yeast
- lipids
- synthesis
- traffic
- funtions
Educational Activity
Course in Charge
- 2020, Liberal Arts Education Program1, 3Term, Cell Science
- 2020, Liberal Arts Education Program1, 2Term, Life, food, and environmental sciences
- 2020, Undergraduate Education, 2Term, Reading of Foreign Literature
- 2020, Undergraduate Education, Intensive, Laboratory Work in General Chemistry
- 2020, Undergraduate Education, 2Term, Introduction to Applied Biological Science I
- 2020, Undergraduate Education, Intensive, Laboratory Work in Molecular Agro-life ScienceIII
- 2020, Undergraduate Education, 4Term, Molecular Cell Biology
- 2020, Undergraduate Education, Intensive, Molecular Cell Biology
- 2020, Undergraduate Education, Academic Year, Graduation Thesis
- 2020, Undergraduate Education, Intensive, Biotechnology
- 2020, Undergraduate Education, 4Term, Bio-Analytical Science
- 2020, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
- 2020, Graduate Education (Doctoral Program) , First Semester, Exercises in Molecular and Applied Biosciences (B)
- 2020, Graduate Education (Doctoral Program) , Second Semester, Exercises in Molecular and Applied Biosciences (B)
- 2020, Graduate Education (Master's Program) , 2Term, Applied Microbiology
- 2020, Graduate Education (Master's Program) , 4Term, Applied Microbiology Seminar
- 2020, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
- 2020, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
- 2020, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
- 2020, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
- 2020, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
- 2020, Graduate Education (Master's Program) , 2Term, Applied Molecular Cell Biology I
- 2020, Graduate Education (Master's Program) , 4Term, Applied Molecular Cell Biology II
Research Activities
Academic Papers
- Ceramide chain length-dependent protein sorting into selective endoplasmic reticulum exit sites., Sci. Adv., 2020
- ★, Tricalbins are required for nonvesicular ceramide transport at ER-Golgi contacts and modulate lipid droplet biogenesis., iScience, 2020
- A defect in GPI synthesis as a suggested mechanism for the role of ARV1 in intellectual disability and seizures., Neurogenetics, 2020
- Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as a GPI flippase., FEBS Lett., 2020
- Expression of two glutamate decarboxylase genes in Lactobacillus brevis during gamma-aminobutyric acid production with date residue extract., Biosci Biotechnol Biochem., 14, 1-4, 2020
- ★, Vesicular and non-vesicular lipid export from the ER to the secretory pathway., Biochim Biophys Acta Mol Cell Biol Lipids., 2020
- Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast., Genetics, 2019
- Lysophospholipids Facilitate COPII Vesicle Formation., Curr Biol., 28(12), 1950-1958, 20180618
- Gamma-aminobutyric acid fermentation with date residue by a lactic acid bacterium, Lactobacillus brevis., J. Biosci. Bioeng., 125(3), 316-319, 201803
- Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast., Curr Genet., 64(5), 1021-1028, 2018
- Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae, MOLECULAR MICROBIOLOGY, 107(3), 363-386, 201802
- Arp2/3 complex and Mps3 are required for regulation of ribosome biosynthesis in the secretory stress response., Yeast, 34(4), 155-163, 201704
- Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis., Yeast, 33, 37-42, 201602
- A lipid regulator working at the cleavage furrow, Cell Cycle, 15(10), 1315-1316, 20160518
- Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy., Hum Mol Genet., 25(14), 3042-3054, 20160715
- COPII Coat Composition Is Actively Regulated by Luminal Cargo Maturation, Curr. Biol., 25(2), 152-162, 20150119
- SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations, Biosci. Biotechnol. Biochem., 79(9), 1481-1483, 20150902
- Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis, J. Cell Sci., 128(14), 2454-2467, 20150715
- The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, Yeast, 32(9), 607-614, 2015
- Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae, SCIENTIFIC REPORTS, 5, 20151117
- Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast, J. Cell Sci., 127(2), 376-387, 20140115
- Metabolic labeling of yeast sphingolipids with radioactive D-erythro-[4,5-3H]dihydrosphingosine., Bio-Protocol (http://www.bio-protocol.org), 3(16), 201308
- Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast, Mol. Microbiol., 86(5), 1246-1261, 2012
- The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling, Mol. Biol. Cell, 22(16), 2924-2936, 20110815
- Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology, Mol. Biol. Cell, 20(7), 2083-2095, 2009
- ★, Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum., Mol. Biol. Cell, 19, 2069-2082, 20080501
- Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway, FEBS Lett., 581(16), 2935-2942, 20070626
- Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae, Mol. Biol. Cell, 17(3), 1164-1175, 2006
- Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae., J. Biol. Chem., 278(9), 7325-7334, 20030228
- Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae., Biochemistry, 41(51), 15105-15114, 20021224
- Sphingolipid biosynthesis and traffic in yeast., Seikagaku, 74(4), 317-321, 20020401
- Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast., J. Biol. Chem., 277(51), 49538-49544, 20021220
- ★, Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast., J. Cell Biol., 155(6), 949-959, 20011210
- Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae., EMBO J., 19(12), 2824-2833, 20000615
- A Salmonella virulence protein inhibits cellular trafficking., EMBO J., 18(14), 3924-3933, 19990715
- A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma., Int J Pharm, 164, 91-102, 1998
- Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation., Int J Pharm, 156, 27-37, 1997
- Sequential actions of Rab5 and Rab7 regulate endocytosis in the Xenopus Oocyte., J. Cell Biol., 136(6), 1227-1237, 19970324
- Rab7 regulates transport from early to late endocytic compartments in Xenopus Oocytes., J. Biol. Chem., 272(20), 13055-13059, 19970516
- ★, Reconstitution of phagosome-lysosome fusion in streptolysin O-permeabilized cells., J. Biol. Chem., 272(26), 16147-16151, 19970627
- Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug., Biopharm Drug Dispos., 17(7), 589-605, 199610
- The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ., J Drug Target, 2, 141-146, 1994
- Plasma factor triggering alternative complement pathway activation by liposomes., Pharm Res., 11, 372-376, 199403
- Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes., Pharm Res., 11(3), 402-406, 199403
- ★, Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma., Biochem. Biophys. Acta, 1103, 198-204, 199201
- Effect of species differences on complement activation by cetylmannoside-modified liposomes in fresh plasma., Drug Delivery System, 7, 165-168, 1992
Publications such as books
- 2006, Sphingolipid Biology, [Sphingolipid Trafficking] pp.123-139, 2006, 0, Scholarly Book, Joint work, 4431341986, 531
- 2018, Advances in Industrial Applications of Yeast, Koji-molds, and Lactic Acid Bacteria, 2018, 1月, Joint work, J