Kouichi Funato

Last Updated :2021/03/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
kfunatohiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, The University of Tokushima
  • Master of Pharmaceutical Science, The University of Tokushima

Research Fields

  • Agricultural sciences;Agricultural chemistry;Applied microbiology
  • Agricultural sciences;Agricultural chemistry;Applied biochemistry

Research Keywords

  • yeast
  • lipids
  • synthesis
  • traffic
  • funtions

Educational Activity

Course in Charge

  1. 2020, Liberal Arts Education Program1, 3Term, Cell Science
  2. 2020, Liberal Arts Education Program1, 2Term, Life, food, and environmental sciences
  3. 2020, Undergraduate Education, 2Term, Introduction to Applied Biological Science I
  4. 2020, Undergraduate Education, Intensive, Laboratory Work in General Chemistry
  5. 2020, Undergraduate Education, 2Term, Reading of Foreign Literature
  6. 2020, Undergraduate Education, Intensive, Laboratory Work in Molecular Agro-life ScienceIII
  7. 2020, Undergraduate Education, 4Term, Molecular Cell Biology
  8. 2020, Undergraduate Education, Intensive, Molecular Cell Biology
  9. 2020, Undergraduate Education, Academic Year, Graduation Thesis
  10. 2020, Undergraduate Education, Intensive, Biotechnology
  11. 2020, Undergraduate Education, 4Term, Bio-Analytical Science
  12. 2020, Undergraduate Education, 3Term, Reading of Foreign Literature in Molecular Agro-Life Science
  13. 2020, Graduate Education (Doctoral Program) , First Semester, Exercises in Molecular and Applied Biosciences (B)
  14. 2020, Graduate Education (Doctoral Program) , Second Semester, Exercises in Molecular and Applied Biosciences (B)
  15. 2020, Graduate Education (Master's Program) , 2Term, Applied Microbiology
  16. 2020, Graduate Education (Master's Program) , 4Term, Applied Microbiology Seminar
  17. 2020, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  18. 2020, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  19. 2020, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  20. 2020, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  21. 2020, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  22. 2020, Graduate Education (Master's Program) , 2Term, Applied Molecular Cell Biology I
  23. 2020, Graduate Education (Master's Program) , 4Term, Applied Molecular Cell Biology II

Research Activities

Academic Papers

  1. Ceramide chain length-dependent protein sorting into selective endoplasmic reticulum exit sites., Sci. Adv., 2020
  2. ★, Tricalbins are required for nonvesicular ceramide transport at ER-Golgi contacts and modulate lipid droplet biogenesis., iScience, 2020
  3. A defect in GPI synthesis as a suggested mechanism for the role of ARV1 in intellectual disability and seizures., Neurogenetics, 2020
  4. Cold-sensitive phenotypes of a yeast null mutant of ARV1 support its role as a GPI flippase., FEBS Lett., 2020
  5. Expression of two glutamate decarboxylase genes in Lactobacillus brevis during gamma-aminobutyric acid production with date residue extract., Biosci Biotechnol Biochem., 14, 1-4, 2020
  6. ★, Vesicular and non-vesicular lipid export from the ER to the secretory pathway., Biochim Biophys Acta Mol Cell Biol Lipids., 2020
  7. Sphingolipid/Pkh1/2-TORC1/Sch9 Signaling Regulates Ribosome Biogenesis in Tunicamycin-Induced Stress Response in Yeast., Genetics, 2019
  8. Lysophospholipids Facilitate COPII Vesicle Formation., Curr Biol., 28(12), 1950-1958, 20180618
  9. Gamma-aminobutyric acid fermentation with date residue by a lactic acid bacterium, Lactobacillus brevis., J. Biosci. Bioeng., 125(3), 316-319, 201803
  10. Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast., Curr Genet., 64(5), 1021-1028, 2018
  11. Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae, MOLECULAR MICROBIOLOGY, 107(3), 363-386, 201802
  12. Arp2/3 complex and Mps3 are required for regulation of ribosome biosynthesis in the secretory stress response., Yeast, 34(4), 155-163, 201704
  13. Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis., Yeast, 33, 37-42, 201602
  14. A lipid regulator working at the cleavage furrow, Cell Cycle, 15(10), 1315-1316, 20160518
  15. Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy., Hum Mol Genet., 25(14), 3042-3054, 20160715
  16. COPII Coat Composition Is Actively Regulated by Luminal Cargo Maturation, Curr. Biol., 25(2), 152-162, 20150119
  17. SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations, Biosci. Biotechnol. Biochem., 79(9), 1481-1483, 20150902
  18. Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis, J. Cell Sci., 128(14), 2454-2467, 20150715
  19. The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts, Yeast, 32(9), 607-614, 2015
  20. Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae, SCIENTIFIC REPORTS, 5, 20151117
  21. Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast, J. Cell Sci., 127(2), 376-387, 20140115
  22. Metabolic labeling of yeast sphingolipids with radioactive D-erythro-[4,5-3H]dihydrosphingosine., Bio-Protocol (http://www.bio-protocol.org), 3(16), 201308
  23. Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast, Mol. Microbiol., 86(5), 1246-1261, 2012
  24. The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling, Mol. Biol. Cell, 22(16), 2924-2936, 20110815
  25. Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology, Mol. Biol. Cell, 20(7), 2083-2095, 2009
  26. ★, Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum., Mol. Biol. Cell, 19, 2069-2082, 20080501
  27. Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway, FEBS Lett., 581(16), 2935-2942, 20070626
  28. Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae, Mol. Biol. Cell, 17(3), 1164-1175, 2006
  29. Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae., J. Biol. Chem., 278(9), 7325-7334, 20030228
  30. Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae., Biochemistry, 41(51), 15105-15114, 20021224
  31. Sphingolipid biosynthesis and traffic in yeast., Seikagaku, 74(4), 317-321, 20020401
  32. Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast., J. Biol. Chem., 277(51), 49538-49544, 20021220
  33. ★, Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast., J. Cell Biol., 155(6), 949-959, 20011210
  34. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae., EMBO J., 19(12), 2824-2833, 20000615
  35. A Salmonella virulence protein inhibits cellular trafficking., EMBO J., 18(14), 3924-3933, 19990715
  36. A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma., Int J Pharm, 164, 91-102, 1998
  37. Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation., Int J Pharm, 156, 27-37, 1997
  38. Sequential actions of Rab5 and Rab7 regulate endocytosis in the Xenopus Oocyte., J. Cell Biol., 136(6), 1227-1237, 19970324
  39. Rab7 regulates transport from early to late endocytic compartments in Xenopus Oocytes., J. Biol. Chem., 272(20), 13055-13059, 19970516
  40. ★, Reconstitution of phagosome-lysosome fusion in streptolysin O-permeabilized cells., J. Biol. Chem., 272(26), 16147-16151, 19970627
  41. Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug., Biopharm Drug Dispos., 17(7), 589-605, 199610
  42. The complement- but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ., J Drug Target, 2, 141-146, 1994
  43. Plasma factor triggering alternative complement pathway activation by liposomes., Pharm Res., 11, 372-376, 199403
  44. Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes., Pharm Res., 11(3), 402-406, 199403
  45. ★, Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma., Biochem. Biophys. Acta, 1103, 198-204, 199201
  46. Effect of species differences on complement activation by cetylmannoside-modified liposomes in fresh plasma., Drug Delivery System, 7, 165-168, 1992

Publications such as books

  1. 2006, Sphingolipid Biology, [Sphingolipid Trafficking] pp.123-139, 2006, 0, Scholarly Book, Joint work, 4431341986, 531
  2. 2018, Advances in Industrial Applications of Yeast, Koji-molds, and Lactic Acid Bacteria, 2018, 1月, Joint work, J