KOJI MATSUHISA
Last Updated :2024/07/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor
Basic Information
Academic Degrees
- Doctor of Philosophy in Pharmaceutical Science, Osaka University
- Master of Pharmaceutical Science, Osaka University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
Research Fields
- Biology;Biological Science;Cell biology
Research Activities
Academic Papers
- p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS, CELL REPORTS, 42(5), 20230530
- Loss of Function of Mutant IDS Due to Endoplasmic Reticulum-Associated Degradation: New Therapeutic Opportunities for Mucopolysaccharidosis Type II, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 20211112
- OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
- Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215
- Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 202001
- Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta 1 subunit, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521(4), 1030-1035, 20200122
- Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation, SCIENTIFIC REPORTS, 9(1), 20301, 20191230
- Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
- Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
- NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 20190104
- Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9(808), 20180724
- Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
- Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
- Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay, SCIENTIFIC REPORTS, 7(1), 14514-14514, 20171106
- The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 20161117
- Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
- Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 20160803
- Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
- IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 20151116
- OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 20151112
- Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), 20150508
- Lignosulfonic acid attenuates NF-kappa B activation and intestinal epithelial barrier dysfunction induced by TNF-alpha/IFN-gamma in Caco-2 cells, JOURNAL OF NATURAL MEDICINES, 72(2), 448-455, 201803
- Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
- ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 201709
- Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 462(1), 52-57, 2015
- Creation and biochemical analysis of a broad-specific claudin binder, BIOMATERIALS, 33(12), 3464-3474, 2012
- Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423(2), 229-233, 2012
- Biochemical analysis of a novel dual claudin binder, FASEB JOURNAL, 25, 2011
- A simple screening system for claudin binders using an scFv library derived from claudin-immunized mice, FASEB JOURNAL, 25, 2011
- Preparation of a dual claudin binder using a fragment of Clostridium perfringens enterotoxin, FASEB JOURNAL, 25, 2011
- A toxicological evaluation of a claudin modulator, the C-terminal fragment of Clostridium perfringens enterotoxin, in mice, Pharmazie, 66(7), 543-546, 2011
- A Claudin-Targeting Molecule as an Inhibitor of Tumor Metastasis, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 334(2), 576-582, 2010
- Tight junction modulator and drug delivery, EXPERT OPINION ON DRUG DELIVERY, 6(5), 509-515, 2009
Invited Lecture, Oral Presentation, Poster Presentation
- The roles of ER-resident transmembrane transcription factor OASIS in cellular senescence of astrocytes, Matsuhisa K, Saito A, Asada R, Kaneko M, Imaizumi K, NEURO2019, 2019/07/26, Without Invitation, English, Niigata
- Retrograde propagation of signaling regulated by UPR branches promotes peripheral nerve regeneration., 2017/12/08, Without Invitation, Japanese
- ER stress-dependent production of small peptides derived from ER stress sensors in neuronal cells, 2017/09/09, Without Invitation, Japanese
- Signaling of the Unfolded Protein Response is Critical for Axon Regeneration after Nerve Injury, 2017/09/07, Without Invitation, Japanese