KOUJI MATSUHISA

Last Updated :2023/01/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Assistant Professor

Basic Information

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Osaka University
  • Master of Pharmaceutical Science, Osaka University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Biology;Biological Science;Cell biology

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 2Term, Cell Science
  2. 2022, Undergraduate Education, Year, Physiology and Biochemistry

Research Activities

Academic Papers

  1. Loss of Function of Mutant IDS Due to Endoplasmic Reticulum-Associated Degradation: New Therapeutic Opportunities for Mucopolysaccharidosis Type II, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(22), 20211112
  2. OASIS/CREB3L1 is a factor that responds to nuclear envelope stress, CELL DEATH DISCOVERY, 7(1), 20210629
  3. Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells, BRAIN RESEARCH, 1749, 20201215
  4. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis, FASEB JOURNAL, 34(1), 865-880, 202001
  5. Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its beta 1 subunit, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521(4), 1030-1035, 20200122
  6. Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation, SCIENTIFIC REPORTS, 9(1), 20301, 20191230
  7. Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(2), 436-442, 20190625
  8. Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 514(1), 217-223, 20190618
  9. NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 294(1), 101-115, 20190104
  10. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II, CELL DEATH & DISEASE, 9(808), 20180724
  11. Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury, NEUROSCIENCE, 375, 34-48, 20180401
  12. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183, PLOS ONE, 13(1), 20180104
  13. Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay, SCIENTIFIC REPORTS, 7(1), 14514-14514, 20171106
  14. The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression, SCIENTIFIC REPORTS, 6, 20161117
  15. Multivesicular body formation enhancement and exosome release during endoplasmic reticulum stress, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 480(2), 166-172, 20161111
  16. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation, SCIENTIFIC REPORTS, 6, 20160803
  17. Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization, JOURNAL OF CELL SCIENCE, 128(23), 4353-4365, 20151201
  18. IRE1 alpha-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes, SCIENTIFIC REPORTS, 5, 20151116
  19. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis, SCIENTIFIC REPORTS, 5, 20151112
  20. Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7, PLOS ONE, 10(5), 20150508
  21. Lignosulfonic acid attenuates NF-kappa B activation and intestinal epithelial barrier dysfunction induced by TNF-alpha/IFN-gamma in Caco-2 cells, JOURNAL OF NATURAL MEDICINES, 72(2), 448-455, 201803
  22. Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma, JOURNAL OF NEUROCHEMISTRY, 144(1), 35-49, 201801
  23. ER Stress and Disease: Toward Prevention and Treatment, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(9), 1337-1343, 201709
  24. Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 462(1), 52-57, 2015
  25. Creation and biochemical analysis of a broad-specific claudin binder, BIOMATERIALS, 33(12), 3464-3474, 2012
  26. Comparison of mucosal absorption-enhancing activity between a claudin-3/-4 binder and a broadly specific claudin binder, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423(2), 229-233, 2012
  27. Biochemical analysis of a novel dual claudin binder, FASEB JOURNAL, 25, 2011
  28. A simple screening system for claudin binders using an scFv library derived from claudin-immunized mice, FASEB JOURNAL, 25, 2011
  29. Preparation of a dual claudin binder using a fragment of Clostridium perfringens enterotoxin, FASEB JOURNAL, 25, 2011
  30. A toxicological evaluation of a claudin modulator, the C-terminal fragment of Clostridium perfringens enterotoxin, in mice, Pharmazie, 66(7), 543-546, 2011
  31. A Claudin-Targeting Molecule as an Inhibitor of Tumor Metastasis, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 334(2), 576-582, 2010
  32. Tight junction modulator and drug delivery, EXPERT OPINION ON DRUG DELIVERY, 6(5), 509-515, 2009

Invited Lecture, Oral Presentation, Poster Presentation

  1. The roles of ER-resident transmembrane transcription factor OASIS in cellular senescence of astrocytes, Matsuhisa K, Saito A, Asada R, Kaneko M, Imaizumi K, NEURO2019, 2019/07/26, Without Invitation, English, Niigata
  2. Retrograde propagation of signaling regulated by UPR branches promotes peripheral nerve regeneration., 2017/12/08, Without Invitation, Japanese
  3. ER stress-dependent production of small peptides derived from ER stress sensors in neuronal cells, 2017/09/09, Without Invitation, Japanese
  4. Signaling of the Unfolded Protein Response is Critical for Axon Regeneration after Nerve Injury, 2017/09/07, Without Invitation, Japanese