MASATSUGU MIYARA

Last Updated :2023/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
Web Site
https://kotakelab.hiroshima-u.ac.jp/homepage/
E-mail
miyara128hiroshima-u.ac.jp
Self-introduction
I investigate the mechanism underlying the toxicity of Parkinsonian neurotoxins (e.g., MPP+ and rotenone) by focusing on the function of organelles (e.g., lysosomes and mitochondria).

Basic Information

Major Professional Backgrounds

  • 2021/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
  • 2018/04/01, 2021/03/31, Japan Society for the Promotion of Science, Research Fellow (PD)
  • 2017/04/01, 2018/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Postdoctoral Researcher
  • 2016/04/01, 2017/03/31, Hiroshima University, Special Postdoctoral Researcher
  • 2014/04/01, 2016/03/31, Japan Society for the Promotion of Science, Research Fellow (DC2)

Educational Backgrounds

  • Hiroshima University, 2012/04/01, 2016/03/23
  • Hiroshima University, 2010/04/01, 2012/03/23
  • Prefectural University of Hiroshima, 2006/04/01, 2010/03/19

Academic Degrees

  • Hiroshima University
  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
  • Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy
  • Biology;Biological Science;Cell biology

Research Keywords

  • Parkinson's disease
  • MPTP/MPP+
  • Autophagy
  • Lysosome

Affiliated Academic Societies

  • The Pharmaceutical Society of Japan
  • The Japanese Society for Neurochemistry
  • The Japanese Society of Toxicology
  • The Molecular Biology Society of Japan

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 2Term, Public Health Chemistry II
  2. 2022, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  3. 2022, Undergraduate Education, First Semester, Experiments of Public health Chemistry

Research Activities

Academic Papers

  1. ★, Trehalose decreases mRNA and protein expressions of c-Jun and JunB in human cervical cancer HeLa cells., Journal of Biochemistry, 172(3), 177-187, 20220905
    Link to Paper Search Results by DOI
  2. ★, Tributyltin inhibits autophagy by decreasing lysosomal acidity in SH-SY5Y cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 592, 31-37, 20220212
    Link to Paper Search Results by DOI
  3. ★, MiT/TFE family members suppress L-leucyl-L-leucine methyl ester-induced cell death., The Journal of Toxicological Sciences, 46(3), 143-156, 2021
    Link to Paper Search Results by DOI
  4. Triphenyltin inhibits GA-binding protein α nuclear translocation., Fundamental Toxicological Sciences, 7(1), 33-40, 2020
    Link to Paper Search Results by DOI
  5. Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons., Archives of Toxicology, 92(1), 401-409, 201806
    Link to Paper Search Results by DOI
  6. Low-concentration tributyltin decreases GluR2 expression via nuclear respiratory factor-1 inhibition., International Journal of Molecular Sciences, 18(8), 1754, 20170811
    Link to Paper Search Results by DOI
  7. ★, Mild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation., Scientific Reports, 7, 46668, 20170426
    Link to Paper Search Results by DOI
  8. Prenatal exposure to tributyltin decreases GluR2 expression in the mouse brain., Biological and Pharmaceutical Bulletin, 40(7), 1121-1124, 2017
    Link to Paper Search Results by DOI
  9. ★, Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism., Journal of Neurochemistry, 139(2), 294-308, 201610
    Link to Paper Search Results by DOI
  10. Protein extracts from cultured cells contain nonspecific serum albumin., Bioscience, Biotechnology, and Biochemistry, 80(6), 1164-1167, 201606
    Link to Paper Search Results by DOI
  11. Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression., The Journal of Toxicological Sciences, 41(2), 255-264, 201604
    Link to Paper Search Results by DOI
  12. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function., Journal of Neurochemistry, 130(6), 826-838, 201409
    Link to Paper Search Results by DOI
  13. Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism., Toxicology and Applied Pharmacology, 272(1), 137-146, 201310
    Link to Paper Search Results by DOI
  14. Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death., The Journal of Toxicological Sciences, 38(3), 513-521, 2013
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Autophagy dysfunction and p62 nuclear accumulation induced by low concentrations of a parkinsonian neurotoxin, 2022/11, With Invitation, Japanese
  2. Exploration of nuclear degradation pathway of a lysosomal stress-responsive transcription factor TFEB, 2022/08, Without Invitation, Japanese
  3. Mechanism of tributyltin-induced LC3-II accumulation, 2022/08, Without Invitation, Japanese
  4. Investigation of the effects of parkinsonian neurotoxin 1BnTIQ on the autophagy-lysosome system, 2022/08, Without Invitation, Japanese
  5. Protein insolubilization induced by mitochondrial dysfunction during starvation, 2022/08, Without Invitation, Japanese
  6. TBT activates Keap1-Nrf2 pathway via Keap1 decrease, 2022/08, Without Invitation, Japanese
  7. Tributyltin accumulates LC3-II via lysosomal dysfunction, Hatamiya S, Miyara M, Kotake Y, 2022/08, Without Invitation, English, Kumamoto
  8. Tributyltin decreases lysosomal acidity and inhibits autophagic degradation, Hatamiya S, Miyara M, Kotake Y, The 8th International Symposium on Metallomics, 2022/07, Without Invitation, English, Kanazawa
  9. Parkinsonian neurotoxin 1BnTIQ inhibits autophagy via lysosomal impairment, 2022/03, Without Invitation, Japanese
  10. Changes in protein properties induced by mitochondrial dysfunction during starvation, 2022/03, Without Invitation, Japanese
  11. Tributyltin activates Nrf2 via Keap1 reduction, 2022/03, Without Invitation, Japanese
  12. Global transcriptome analysis in low concentration of MPP+-induced cellular model of Parkinson's disease, Natsumi Okada, Masatsugu Miyara, Kanae Miyara, Miyuki Kanda, Hidetoshi Tahara, Yaichiro Kotake, 2021/09, Without Invitation, Japanese
  13. Tributyltin inhibits autophagy via lysosomal dysfunction, Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake, 2021/07, Without Invitation, Japanese
  14. Mild parkinsonian neurotoxin MPP+ exposure disrupts lysosomal gene expression, Natsumi Okada, Masatsugu Miyara, Kanae Miyara, Shunichi Hatamiya, Yusuke Kojima, Saya Takao, Yaichiro Kotake, 2021/03, Without Invitation, Japanese
  15. Tributyltin impairs autophagy, Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake, 2021/03, Without Invitation, Japanese
  16. Mild parkinsonian neurotoxin exposure induces autophagy dysfunction and nuclear p62 accumulation, Masatsugu Miyara, Wataru Tokunaga, Yuka Kuwabara, Namiko Watanabe, Shunichi Hatamiya, Tsuyoshi Nakanishi, Yaichiro Kotake, 2020/03, Without Invitation, Japanese
  17. Trehalose decreases Akt mRNA and protein expression, Kanae Umeda, Masatsugu Miyara, Shunichi Hatamiya, Yaichiro Kotake, 2020/03, Without Invitation, Japanese, Kyoto
  18. Reduced protein expression of lysosomal enzyme induced by 1BnTIQ, an endogenous Parkinson's disease-related neurotoxin, Ayaka Yabuki, Masatsugu Miyara, Kanae Umeda, Natsumi Okada, Namiko Watanabe, Shigeru Ohta, Yaichiro Kotake, 2020/03, Without Invitation, Japanese
  19. Endogenous parkinsonian neurotoxin 1BnTIQ impairs autophagic degradation, Miyara M, Yabuki A, Okada N, Umeda K, Nishio T, Yamada S, Kanda Y, Nakanishi T, Ohta S, Kotake Y, 2019/08, Without Invitation, English
  20. Inhibition of autophagy induced by 1BnTIQ, an endogenous Parkinson's disease-related neurotoxin, 2019/06, Without Invitation, Japanese
  21. Neurotoxic factors in Parkinson's disease., Ohta S, Kotake Y, Kohta R, Miyara M, Contu VR, Annual Meeting of the German Pharmaceutical Society, 2013/10, With Invitation, English, Freiburg
  22. Low concentration of Parkinson's disease-related neurotoxin MPP+ inhibits autophagy, Miyara M, Kotake Y, Ohta S, The XIII International Congress of Toxicology, 2013/07, Without Invitation, English, Seoul
  23. Inhibition of autophagic flux induced by low concentration of 1-methyl-4-phenylpyridinium ion, Miyara M, Kotake Y, Aoyama K, Ohta S, Society for Neuroscience 2012, 2012/10, Without Invitation, English, New Orleans
  24. Impairment of autophagy induced by low concentration of MPP+, a Parkinson's disease-related toxin, Miyara M, Kotake Y, Ohta S, The 6th International Symposium on Autophagy 2012, 2012/10, Without Invitation, English, Nago
  25. Involvement of autophagy in low concentration of MPP+-induced neuronal cell death, Miyara M, Kotake Y, Hirokane Y, Ohta S, The 6th International Congress of Asian Society of Toxicology, 2012/07, Without Invitation, English, Sendai

External Funds

Acceptance Results of Competitive Funds

  1. 2022/04/01, 2024/03/31
  2. 2020/04/01, 2024/03/31
  3. 2020/04, 2022/03
  4. 2018/04, 2021/03
  5. 2018/06, 2020/03
  6. 2017/12, 2019/03
  7. 2017/04, 2018/03
  8. 2017/03, 2018/02
  9. 2014/04, 2016/03