MASATSUGU MIYARA
Last Updated :2023/02/02
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Assistant Professor
- Web Site
- E-mail
- miyara128
hiroshima-u.ac.jp
- Self-introduction
- I investigate the mechanism underlying the toxicity of Parkinsonian neurotoxins (e.g., MPP+ and rotenone) by focusing on the function of organelles (e.g., lysosomes and mitochondria).
Basic Information
Major Professional Backgrounds
- 2021/04/01, Hiroshima University, Graduate School of Biomedical and Health Sciences, Assistant Professor
- 2018/04/01, 2021/03/31, Japan Society for the Promotion of Science, Research Fellow (PD)
- 2017/04/01, 2018/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Postdoctoral Researcher
- 2016/04/01, 2017/03/31, Hiroshima University, Special Postdoctoral Researcher
- 2014/04/01, 2016/03/31, Japan Society for the Promotion of Science, Research Fellow (DC2)
Educational Backgrounds
- Hiroshima University, 2012/04/01, 2016/03/23
- Hiroshima University, 2010/04/01, 2012/03/23
- Prefectural University of Hiroshima, 2006/04/01, 2010/03/19
Academic Degrees
- Hiroshima University
- Hiroshima University
Research Fields
- Medicine,dentistry, and pharmacy;Pharmacy;Environmental and hygienic pharmacy
- Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy
- Biology;Biological Science;Cell biology
Research Keywords
- Parkinson's disease
- MPTP/MPP+
- Autophagy
- Lysosome
Affiliated Academic Societies
- The Pharmaceutical Society of Japan
- The Japanese Society for Neurochemistry
- The Japanese Society of Toxicology
- The Molecular Biology Society of Japan
Research Activities
Academic Papers
- ★, Trehalose decreases mRNA and protein expressions of c-Jun and JunB in human cervical cancer HeLa cells., Journal of Biochemistry, 172(3), 177-187, 20220905
- ★, Tributyltin inhibits autophagy by decreasing lysosomal acidity in SH-SY5Y cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 592, 31-37, 20220212
- ★, MiT/TFE family members suppress L-leucyl-L-leucine methyl ester-induced cell death., The Journal of Toxicological Sciences, 46(3), 143-156, 2021
- Triphenyltin inhibits GA-binding protein α nuclear translocation., Fundamental Toxicological Sciences, 7(1), 33-40, 2020
- Carbofuran causes neuronal vulnerability to glutamate by decreasing GluA2 protein levels in rat primary cortical neurons., Archives of Toxicology, 92(1), 401-409, 201806
- Low-concentration tributyltin decreases GluR2 expression via nuclear respiratory factor-1 inhibition., International Journal of Molecular Sciences, 18(8), 1754, 20170811
- ★, Mild MPP+ exposure-induced glucose starvation enhances autophagosome synthesis and impairs its degradation., Scientific Reports, 7, 46668, 20170426
- Prenatal exposure to tributyltin decreases GluR2 expression in the mouse brain., Biological and Pharmaceutical Bulletin, 40(7), 1121-1124, 2017
- ★, Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity-independent mechanism., Journal of Neurochemistry, 139(2), 294-308, 201610
- Protein extracts from cultured cells contain nonspecific serum albumin., Bioscience, Biotechnology, and Biochemistry, 80(6), 1164-1167, 201606
- Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression., The Journal of Toxicological Sciences, 41(2), 255-264, 201604
- Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function., Journal of Neurochemistry, 130(6), 826-838, 201409
- Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism., Toxicology and Applied Pharmacology, 272(1), 137-146, 201310
- Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death., The Journal of Toxicological Sciences, 38(3), 513-521, 2013
Invited Lecture, Oral Presentation, Poster Presentation
- Autophagy dysfunction and p62 nuclear accumulation induced by low concentrations of a parkinsonian neurotoxin, 2022/11, With Invitation, Japanese
- Exploration of nuclear degradation pathway of a lysosomal stress-responsive transcription factor TFEB, 2022/08, Without Invitation, Japanese
- Mechanism of tributyltin-induced LC3-II accumulation, 2022/08, Without Invitation, Japanese
- Investigation of the effects of parkinsonian neurotoxin 1BnTIQ on the autophagy-lysosome system, 2022/08, Without Invitation, Japanese
- Protein insolubilization induced by mitochondrial dysfunction during starvation, 2022/08, Without Invitation, Japanese
- TBT activates Keap1-Nrf2 pathway via Keap1 decrease, 2022/08, Without Invitation, Japanese
- Tributyltin accumulates LC3-II via lysosomal dysfunction, Hatamiya S, Miyara M, Kotake Y, 2022/08, Without Invitation, English, Kumamoto
- Tributyltin decreases lysosomal acidity and inhibits autophagic degradation, Hatamiya S, Miyara M, Kotake Y, The 8th International Symposium on Metallomics, 2022/07, Without Invitation, English, Kanazawa
- Parkinsonian neurotoxin 1BnTIQ inhibits autophagy via lysosomal impairment, 2022/03, Without Invitation, Japanese
- Changes in protein properties induced by mitochondrial dysfunction during starvation, 2022/03, Without Invitation, Japanese
- Tributyltin activates Nrf2 via Keap1 reduction, 2022/03, Without Invitation, Japanese
- Global transcriptome analysis in low concentration of MPP+-induced cellular model of Parkinson's disease, Natsumi Okada, Masatsugu Miyara, Kanae Miyara, Miyuki Kanda, Hidetoshi Tahara, Yaichiro Kotake, 2021/09, Without Invitation, Japanese
- Tributyltin inhibits autophagy via lysosomal dysfunction, Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake, 2021/07, Without Invitation, Japanese
- Mild parkinsonian neurotoxin MPP+ exposure disrupts lysosomal gene expression, Natsumi Okada, Masatsugu Miyara, Kanae Miyara, Shunichi Hatamiya, Yusuke Kojima, Saya Takao, Yaichiro Kotake, 2021/03, Without Invitation, Japanese
- Tributyltin impairs autophagy, Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake, 2021/03, Without Invitation, Japanese
- Mild parkinsonian neurotoxin exposure induces autophagy dysfunction and nuclear p62 accumulation, Masatsugu Miyara, Wataru Tokunaga, Yuka Kuwabara, Namiko Watanabe, Shunichi Hatamiya, Tsuyoshi Nakanishi, Yaichiro Kotake, 2020/03, Without Invitation, Japanese
- Trehalose decreases Akt mRNA and protein expression, Kanae Umeda, Masatsugu Miyara, Shunichi Hatamiya, Yaichiro Kotake, 2020/03, Without Invitation, Japanese, Kyoto
- Reduced protein expression of lysosomal enzyme induced by 1BnTIQ, an endogenous Parkinson's disease-related neurotoxin, Ayaka Yabuki, Masatsugu Miyara, Kanae Umeda, Natsumi Okada, Namiko Watanabe, Shigeru Ohta, Yaichiro Kotake, 2020/03, Without Invitation, Japanese
- Endogenous parkinsonian neurotoxin 1BnTIQ impairs autophagic degradation, Miyara M, Yabuki A, Okada N, Umeda K, Nishio T, Yamada S, Kanda Y, Nakanishi T, Ohta S, Kotake Y, 2019/08, Without Invitation, English
- Inhibition of autophagy induced by 1BnTIQ, an endogenous Parkinson's disease-related neurotoxin, 2019/06, Without Invitation, Japanese
- Neurotoxic factors in Parkinson's disease., Ohta S, Kotake Y, Kohta R, Miyara M, Contu VR, Annual Meeting of the German Pharmaceutical Society, 2013/10, With Invitation, English, Freiburg
- Low concentration of Parkinson's disease-related neurotoxin MPP+ inhibits autophagy, Miyara M, Kotake Y, Ohta S, The XIII International Congress of Toxicology, 2013/07, Without Invitation, English, Seoul
- Inhibition of autophagic flux induced by low concentration of 1-methyl-4-phenylpyridinium ion, Miyara M, Kotake Y, Aoyama K, Ohta S, Society for Neuroscience 2012, 2012/10, Without Invitation, English, New Orleans
- Impairment of autophagy induced by low concentration of MPP+, a Parkinson's disease-related toxin, Miyara M, Kotake Y, Ohta S, The 6th International Symposium on Autophagy 2012, 2012/10, Without Invitation, English, Nago
- Involvement of autophagy in low concentration of MPP+-induced neuronal cell death, Miyara M, Kotake Y, Hirokane Y, Ohta S, The 6th International Congress of Asian Society of Toxicology, 2012/07, Without Invitation, English, Sendai
External Funds
Acceptance Results of Competitive Funds
- 2022/04/01, 2024/03/31
- 2020/04/01, 2024/03/31
- 2020/04, 2022/03
- 2018/04, 2021/03
- 2018/06, 2020/03
- 2017/12, 2019/03
- 2017/04, 2018/03
- 2017/03, 2018/02
- 2014/04, 2016/03