RIKU KAWASAKI

Last Updated :2024/10/02

Affiliations, Positions
Graduate School of Advanced Science and Engineering, Associate Professor
Web Site
https://ikedalab.wixsite.com/mysite
E-mail
riku0528hiroshima-u.ac.jp
Self-introduction
I have mainly studied functional biomaterials based on supramolecular chemistry. Especially, I developed drug delivery system with hydrophobized polysaccharide for cancer therapy, protein delivery and bio-imaging.

Basic Information

Major Professional Backgrounds

  • 2017/04, 2017/08, Graduated School of Engineering, Kyoto University, Post-doctoral Researcher
  • 2017/09, 2018/08, University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Science, Post-doctoral researcher
  • 2018/09, 2019/09, RIKEN, Post-doctoral Researcher
  • 2019/10/01, 2020/03/31, Hiroshima University, Graduated School of Engineering, Assistant Professor

Educational Backgrounds

  • Kyoto University, Engineering, Polymer Chemistry, Japan, 2014/04, 2017/03
  • Osaka City University, Engineering, Applied Chemistry and Biochemistry, Japan, 2012/04, 2014/03
  • Osaka City University, Engineering, Bioengineering, Japan, 2008/04, 2012/03

Academic Degrees

  • Osaka City University
  • Kyoto University

Research Fields

  • Complex systems;Biomedical engineering;Biomedical engineering / Biomaterial science and engineering

Research Keywords

  • Supramolecular Chemistry, Self-assembly, Nanoparticle, Hydrogel, Biomaterial, Drug Delivery System, Regenerative medicine, Organic-inorganic hybrid material, Bioimaging contrast agent, Biomedical engineering, Biopharmaceutics, polysaccharide, Exosome

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, General Chemistry
  2. 2024, Undergraduate Education, 1Term, Analytical Chemistry
  3. 2024, Undergraduate Education, 4Term, Exercises in Organic Chemistry
  4. 2024, Undergraduate Education, First Semester, Chemical Experiments I
  5. 2024, Undergraduate Education, 3Term, Quantum Chemistry III
  6. 2024, Undergraduate Education, Year, Graduation Thesis
  7. 2024, Graduate Education (Master's Program) , 1Term, Special Exercises on Applied Chemistry A
  8. 2024, Graduate Education (Master's Program) , 2Term, Special Exercises on Applied Chemistry A
  9. 2024, Graduate Education (Master's Program) , 1Term, Special Exercises on Applied Chemistry A
  10. 2024, Graduate Education (Master's Program) , 2Term, Special Exercises on Applied Chemistry A
  11. 2024, Graduate Education (Master's Program) , 3Term, Special Exercises on Applied Chemistry B
  12. 2024, Graduate Education (Master's Program) , 4Term, Special Exercises on Applied Chemistry B
  13. 2024, Graduate Education (Master's Program) , 3Term, Special Exercises on Applied Chemistry B
  14. 2024, Graduate Education (Master's Program) , 4Term, Special Exercises on Applied Chemistry B
  15. 2024, Graduate Education (Master's Program) , Academic Year, Special Study on Applied Chemistry
  16. 2024, Graduate Education (Master's Program) , Academic Year, Special Study on Applied Chemistry
  17. 2024, Graduate Education (Master's Program) , 2Term, Biomaterial Engineering

Research Activities

Academic Papers

  1. Water Solubilization and Guest Molecule-Induced Fluorescence Changes of Porous Host Molecules via Complexing with Polysaccharide or Polypeptide, CHEMISTRY-AN ASIAN JOURNAL, 19(8), 20240416
    Link to Paper Search Results by DOI
  2. HER-2-Targeted Boron Neutron Capture Therapy with Carborane-integrated Immunoliposomes Prepared via an Exchanging Reaction, CHEMISTRY-A EUROPEAN JOURNAL, 29(72), 20231222
    Link to Paper Search Results by DOI
  3. Fluorescence Turn-on of Tetraphenylethylene Derivative by Transfer from Cyclodextrin to Liposomes, HeLa Cells, and E. coli, CHEMISTRY-A EUROPEAN JOURNAL, 29(10), 20230216
    Link to Paper Search Results by DOI
  4. Phospholipid-Coated Boronic Oxide Nanoparticles as Boron Agents for Boron Neutron Capture Therapy, CHEMBIOCHEM, 24(15), 20230801
    Link to Paper Search Results by DOI
  5. Selective Photodynamic Activity of Tetrakis(4-aminophenyl)porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells, CHEMISTRY-A EUROPEAN JOURNAL, 29(47), 20230821
    Link to Paper Search Results by DOI
  6. Selective Photodynamic Activity of Tetrakis(4-aminophenyl)porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells, CHEMISTRY-A EUROPEAN JOURNAL, 29(47), 20230821
    Link to Paper Search Results by DOI
  7. On-Off Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents, CHEMBIOCHEM, 24(21), 20231102
    Link to Paper Search Results by DOI
  8. HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/beta-1,3-glucan complex, NANOSCALE ADVANCES, 5(15), 20230725
    Link to Paper Search Results by DOI
  9. Development of water-soluble phenazine-2,3-diol-based photosensitizers for singlet oxygen generation, ORGANIC & BIOMOLECULAR CHEMISTRY, 21(25), 5194-5202, 20230628
    Link to Paper Search Results by DOI
  10. ★, Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 49, 202304
    Link to Paper Search Results by DOI
  11. Improvement in photodynamic activity by a porphyrin-fullerene composite system in lipid membranes, ORGANIC & BIOMOLECULAR CHEMISTRY, 21(23), 4810-4816, 20230614
    Link to Paper Search Results by DOI
  12. Development of a Water-Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy, MACROMOLECULAR BIOSCIENCE, 23(4), 202304
    Link to Paper Search Results by DOI
  13. Drug-Loaded Biocompatible Chitosan Polymeric Films with Both Stretchability and Controlled Release for Drug Delivery, ACS OMEGA, 8(1), 1282-1290, 20230110
    Link to Paper Search Results by DOI
  14. Oncogenic RAS Networks Suppression: Reversibly Ionic Oligonucleotide-Based Nanoparticles Caged microRNA-143 Inhibit KRAS-Mutated Colon Cancer Growth in Tumor-Bearing Mice, ADVANCED THERAPEUTICS, 6(2), 202302
    Link to Paper Search Results by DOI
  15. Fluorescence sensor using porous host molecules deposited on filter paper with vapochromic and mechanochromic properties, NEW JOURNAL OF CHEMISTRY, 47(9), 4166-4171, 20230227
    Link to Paper Search Results by DOI
  16. Aqueous solutions with information on solids: room-temperature phosphorescence of polysaccharide-benzophenone complexes, RSC ADVANCES, 13(6), 3528-3533, 20230124
    Link to Paper Search Results by DOI
  17. Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique, RSC ADVANCES, 12(49), 32012-32019, 20221103
    Link to Paper Search Results by DOI
  18. Aqueous Solutions of a Porous Host–Poly-L-lysine Complex with Information on Solids as Different Fluorescence by Guests, Chemistry an Asian Journal, e20220879, 1-4, 20220927
  19. Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique, RSC Advances, 12, 32012-32019, 20221108
  20. Cyclodextrin-induced release of drug-entrapping liposomes associated with the solation of liposome gels, RSC ADVANCES, 12(34), 22202-22209, 20220804
    Link to Paper Search Results by DOI
  21. Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9), 202205
    Link to Paper Search Results by DOI
  22. Effect of meso Positioned Substituents on the Stability and Photodynamic Activity of Lipid-Membrane-Incorporated Porphyrin Derivatives, CHEMMEDCHEM, 17(9), 20220504
    Link to Paper Search Results by DOI
  23. Improvement of Photodynamic Activity by a Stable System Consisting of a C-60 Derivative and Photoantenna in Liposomes br, ACS MEDICINAL CHEMISTRY LETTERS, 13(4), 641-647, 20220414
    Link to Paper Search Results by DOI
  24. Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy, Int. J. Mol. Sci., 23, 4686, 2022
  25. Effect of meso Positioned Substituents on the Stability and Photodynamic Activity of Lipid-Membrane Incorporated Porphyrin Derivatives, ChemMedChem, 17(e202200070), 2022
  26. 25) Improvement of Photodynamic Activity by a Stable System Consisting of a C60 Derivative and Photo-Antenna in Liposome, ACS Med. Chem. Lett., 13, 641-647, 2022
  27. ★, Magnetically guided protein transduction by hybrid nanogel chaperones with iron oxide nanoparticles, Angewandte Chemie International Edition, 128, 11377-11381, 2016
  28. ★, Intracellular delivery and passive tumor targeting of a self-assembled nanogel containing clusters for boron neutron capture therapy, Biochemical and Biophysical Research Communications, 483, 147-152, 2017
  29. ★, Calcium-deficient hydroxyapatite as a potential sorbent for strontium, Scientific Reports, 7, 2064, 2017
  30. ★, Magnetically navigated intracellular delivery of extracellular vesicles using amphiphilic nanogels, Bioconjugate Chemistry, 30, 2150-2154, 2019
  31. Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering, Biomaterials Science, 2, 619-630, 2020
    Link to Paper Search Results by DOI
  32. Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in Beta-(1,3-1,6)-D-Glucan with On-Off Switch, Chemistry An Asian Journal, 15, 365-370, 2020
    Link to Paper Search Results by DOI
  33. Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in beta-(1,3-1,6)-d-Glucan with On-Off Switch, CHEMISTRY-AN ASIAN JOURNAL, 15(3), 365-370, 20200203
    Link to Paper Search Results by DOI
  34. Aggregation-Induced Emission and Retention of Crystal Chiral Information of Tetraphenylethylene Incorporated by Polysaccharides in Water, CHEMPHOTOCHEM, 4(8), 577-581, 202008
    Link to Paper Search Results by DOI
  35. Improved water solubility and photodynamic activity of hydroxy-modified porphyrins by complexation with cyclodextrin, ORGANIC & BIOMOLECULAR CHEMISTRY, 18(34), 6702-6709, 20200914
    Link to Paper Search Results by DOI
  36. Hydrogen Sulfide-Responsive Self-Assembled Nanogel, ACS APPLIED POLYMER MATERIALS, 2(9), 3756-3760, 20200911
    Link to Paper Search Results by DOI
  37. Water Solubilization of Phthalocyanine Derivatives via Interactions of Long Alkyl Chains and Cyclodextrins: Potential Complexes for Photodynamic Therapy, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 9(10), 1589-1596, 202010
    Link to Paper Search Results by DOI
  38. Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes, NANOSCALE ADVANCES, 2(10), 4395-4399, 20201001
    Link to Paper Search Results by DOI
  39. Solubilization of Tetrahydroxyphenylchlorin in Water and Improved Photodynamic Activity after Complexation with Cyclic Oligo- and Polysaccharides, ACS APPLIED BIO MATERIALS, 3(5), 3217-3225, 20200518
    Link to Paper Search Results by DOI
  40. Fullerene-porphyrin hybrid nanoparticles that generate activated oxygen by photoirradiation, RSC ADVANCES, 11(3), 1564-1568, 20210113
    Link to Paper Search Results by DOI
  41. Water Solubilization and Thermal Stimuli-Triggered Release of Porphyrin Derivatives Using Thermoresponsive Polysaccharide Hydroxypropyl Cellulose for Mitochondria-Targeted Photodynamic Therapy, ACS OMEGA, 6(4), 3209-3217, 20210202
    Link to Paper Search Results by DOI
  42. Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells, CHEMMEDCHEM, 16(5), 793-803, 20210303
    Link to Paper Search Results by DOI
  43. ★, Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 559, 210-216, 20210625
    Link to Paper Search Results by DOI
  44. ★, Development of Reactive Oxygen Species-Triggered Degradable Nanoparticles Using Oligoproline-containing Peptides, Biomacromolecules, 21, 1589-1596
  45. ★, Magnetically navigated protein transduction in vivo using iron-oxide-nanogel chaperone hybrid, Advanced Healthcare Materials, 10, 2001988, 20210308
  46. ★, Nanoscale polyion complex vesicles for delivery of cargo proteins and Cas9 ribonucleoprotein complexes to plant cells, ACS Applied Nano Materials, 20210603
  47. Development of Reactive Oxygen Species-Triggered Degradable Nanoparticles Using Oligoproline-Containing Peptides, BIOMACROMOLECULES, 21(10), 4116-4122, 202010
    Link to Paper Search Results by DOI
  48. Photodynamic therapy using self-assembled nanogels comprising chlorin e6-bearing pullulan, JOURNAL OF MATERIALS CHEMISTRY B, 9(32), 6357-6363, 20210828
    Link to Paper Search Results by DOI
  49. Preparation of Aqueous Solutions with Information on Solids (ASIS) of a Mechanochromic Luminescent Tetraphenylethylene Derivative by Complexation with Polysaccharides, ACS APPLIED POLYMER MATERIALS, 3(8), 3708-3713, 20210813
    Link to Paper Search Results by DOI
  50. Simple Formation of Cancer Drug-Containing Self-Assembled Hydrogels with Temperature and pH-Responsive Release, LANGMUIR, 37(38), 11269-11275, 20210928
    Link to Paper Search Results by DOI
  51. Photo-triggered cargo release from liposome chlorin e6-bearing pullulan hybrid nanoparticles via membrane permeabilization, RSC ADVANCES, 11(58), 36564-36568, 20211112
    Link to Paper Search Results by DOI
  52. Water solubilization of paclitaxel using polypeptides for cancer therapy, MATERIALS ADVANCES, 3(1), 467-473, 20220104
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Fullerene Nanocrystal-Gold Nanoparticle Hybrid for Theranostic Agent-Based on Photothermal Therapy and Photoacoustic Imaging, R. Kawasaki, K. Kondo, R. Miura, K. Yamana, H. Isozaki, S. Kawamura, T. Nishimura, N. Tarutani, K. Katagiri, S. Sawada, Y. Sasaki, K. Akiyoshi, A. Ikeda, Kyoto University / ERATO International Symposium Chemistry and Plant Biology, 2022/03/15, Without Invitation, Japanese, Kyoto University / JST-ERATO
  2. The Complex of Pyrene-substituted Carborane with Hyaluronic Acid for Tumor-Targeted Boron Neutron Capture Therapy, K. Yamana, R. Kawasaki, Y. Sanada, A. Tabata, K. Bando, K. Yoshikawa, H. Azuma, Y. Sakurai, S. Masunaga, M. Suzuki, K. Suzuki, T. Nagasaki, A. Ikeda, Kyoto University / ERATO International Symposium Chemistry and Plant Biology, 2022/03/15, Without Invitation, English, Kyoto University / JST-ERATO, Kyoto University

Awards

  1. 2014, Excellent Poster Award, Asian Arden Conference
  2. 2016, Bioconjugate Chemistry Award, SPSJ
  3. 2017, Editor's Choice, The Chemistry of Society of Japan

Patented

  1. Patent

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2022, 2024
  2. Strategic Basic Research Programs(ACT-X), 2022//1/0/, 2025//0/3/
  3. Adaptable and Seamless Technology transfer Program through targetdriven R&D(A-STEP), 2021/05/01, 2022/03/31
  4. 2021/07, 2022/03
  5. JST-A-STEP, 2021/04, 2022/03
  6. 2021/03/01, 2023/02/28
  7. 2021/02/01, 2022/04/30
  8. 2020/10/01, 2021/09/30
  9. 2020/08/01, 2021/03/31
  10. 2020/04, 2021/03
  11. 2020/04, 2021/03
  12. 2019/04, 2022/03
  13. 2017/09, 2018/08
  14. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2019, 2021