TAKAKI ASANO

Last Updated :2025/04/11

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Associate Professor
E-mail
tasano02hiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2023/04/01, Hiroshima university, Associate professor
  • 2022/04/01, 2023/03/31, Hiroshima University, Hospital, Assistant professor
  • 2019/10/01, 2022/03/31, The Rockefeller University, St. Giles Laboratory of Human Genetics of Infectious Diseases, Postdoctral Associate
  • 2019/01/04, 2019/09/30, Funairi Citizens Hospital, Assistant director
  • 2018/11/01, 2018/12, Onomichi general hospital, Assistant director
  • 2018/06/01, 2018/10/31, Hiroshima University, Hospital, Clinical fellow
  • 2015/04/01, 2018/05/31, Hiroshima University, Hospital, Clinical staff
  • 2014/04/01, 2015/03/31, Hiroshima Nishi Medical Center, Clinical fellow
  • 2011/04/01, 2013/03/31, Hiroshima University, Hospital, Clinical fellow
  • 2009/04/01, 2011/03/31, Funairi Hospital, Clinical fellow
  • 2008/04/01, 2009/03/31, TOYOTA memorial hospital, Clinical fellow
  • 2006/04/01, 2008/03/31, TOYOTA memorial hospital, Clinical Resident

Educational Backgrounds

  • Hiroshima University, 2013/04, 2018/05
  • Hiroshima university, 2000/04, 2006/03

Academic Degrees

  • Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Pediatrics

Research Keywords

  • Inborn errors of immunity
  • COVID-19
  • Hyper IgE syndrome
  • Mendelian susceptibility to mycobacterial disease
  • Chronic mucocutaneous candidiasis
  • Combined immunodeficiencies
  • Isolated congenital asplenia

Affiliated Academic Societies

  • European Society for Immunodeficiencies (ESID)
  • Asia Pacific Society for Immunodeficiencies
  • Japan Pediatric Society
  • Japanese Society for Immunodeficiency and Autoinflammatory Diseases
  • The Japan Society of Human Genetics
  • The japanese Society of Clinical Immunology
  • Japanese College of Rheumatology
  • Japanese Society of Pediatric Infectious Diseases
  • Japanese Society of hematology
  • Japanese Society for Immunology
  • The Japan Society of Pediatric Genetics

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, First Semester, Radiation Biology & Radiation Health Risk Sciences
  2. 2025, Undergraduate Education, First Semester, Human genetics
  3. 2025, Undergraduate Education, 2Term, Pediatrics
  4. 2025, Undergraduate Education, 2Term, Pediatrics
  5. 2025, Graduate Education (Master's Program) , 1Term, Medical Ethics A
  6. 2025, Graduate Education (Doctoral Program) , 3Term, Medical Ethics B
  7. 2025, Graduate Education (Doctoral Program) , 1Term, Integrated Radiation Medical Science

Research Activities

Academic Papers

  1. Anti-cytokine autoantibodies in human susceptibility to infectious diseases: insights from Inborn errors of immunity, Immunological Medicine, 20250408
  2. Pulmonary Aspergillosis and Low HIES Score in a Family with STAT3 N‑Terminal Domain Mutation, Journal of clinical immunology, 45, 20250210
  3. Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling, IMMUNITY, 57(12), 20241210
    Link to Paper Search Results by DOI
  4. Prolonged diagnostic journey in delayed-onset adenosine deaminase deficiency, CLINICAL IMMUNOLOGY, 270, 202501
    Link to Paper Search Results by DOI
  5. A case of primary ciliary dyskinesis with DRC1 deletion and literature review: Additional evidence on the founder effect, PEDIATRICS INTERNATIONAL, 66(1), 202401
    Link to Paper Search Results by DOI
  6. Immunophenotyping and Therapeutic Insights from Chronic Mucocutaneous Candidiasis Cases with STAT1 Gain-of-Function Mutations, JOURNAL OF CLINICAL IMMUNOLOGY, 44(8), 202412
    Link to Paper Search Results by DOI
  7. Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency, JOURNAL OF CLINICAL IMMUNOLOGY, 44(7), 202410
    Link to Paper Search Results by DOI
  8. Inherited CARD9 Deficiency Due to a Founder Effect in East Asia, JOURNAL OF CLINICAL IMMUNOLOGY, 44(5), 202406
    Link to Paper Search Results by DOI
  9. Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 151(4), 818-831, 202304
    Link to Paper Search Results by DOI
  10. Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research, IMMUNOLOGICAL REVIEWS, 322(1), 81-97, 202403
    Link to Paper Search Results by DOI
  11. Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children, JOURNAL OF EXPERIMENTAL MEDICINE, 221(2), 20240104
    Link to Paper Search Results by DOI
  12. Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function, JOURNAL OF CLINICAL IMMUNOLOGY, 44(1), 202401
    Link to Paper Search Results by DOI
  13. Isolated Chronic Mucocutaneous Candidiasis due to a Novel Duplication Variant of IL17RC, JOURNAL OF CLINICAL IMMUNOLOGY, 44(1), 202401
    Link to Paper Search Results by DOI
  14. Higher COVID-19 pneumonia risk associated with anti-IFN-alpha than with anti-IFN-omega auto-Abs in children, J. Exp. Med, 221(2), 202402
  15. Isolated Chronic Mucocutaneous Candidiasis due to a Novel Duplication Variant of IL17RC, J. Clin. Immunol, 44(18), 2024
  16. ★, Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research, Immunological reviews, 1-17, 202311
  17. Fatal COVID-19 infection in two children with STAT1 gain-of-function, J. Clin. Immunol, 44(20), 2024
  18. A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis, PNAS NEXUS, 2(4), 20230403
    Link to Paper Search Results by DOI
  19. Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity, JOURNAL OF EXPERIMENTAL MEDICINE, 220(9), 20230605
    Link to Paper Search Results by DOI
  20. Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3K delta syndrome 2, JOURNAL OF EXPERIMENTAL MEDICINE, 220(6), 20230321
    Link to Paper Search Results by DOI
  21. Human genetic and immunological determinants of critical COVID-19 pneumonia, NATURE, 603(7902), 587-598, 20220324
    Link to Paper Search Results by DOI
  22. Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity, J Exp Med, 220(9), e20212276, 20230605
  23. ★, Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 212(2), 96-106, 20230425
    Link to Paper Search Results by DOI
  24. ★, Inborn errors of immunity with loss- and gain-of-function germline mutations in STAT1, Clinical and Experimental Immunology,, 222(2), 96-106, 202304
  25. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19, Genome Med, 15(22), 202304
  26. Proteomic analysis is complementary to targeted RNA sequencing and improves diagnostic yield in Inborn Errors of Immunity, PNAS Nexus, 2(4), 202303
  27. Novel NF-kappa B Inhibitor Alpha Gain of Function Variant in an Infant with Lymphocytosis and Recurrent Serratia Bacteremia., J Clin Immunol, 202304
  28. Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3K- delta syndrome 2, J Exp Med, 220(6), e20221020, 202303
  29. Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia, J Exp Med, 219(8), e20220131, 20220616
  30. Isolated congenital asplenia: An overlooked cause of thrombocytosis. American Journal of Hematology, Am J Hematol, 20220309
  31. Human genetic and immunological determinants of critical COVID-19 pneumonia., Nature, 603(7902), 587-598, 20220128
  32. X-linked TLR7 deficiency underlies critical COVID-19 pneumonia in a male patient with ataxia-telangiectasia, J. Clin. Immunol, 42(1), 1-9, 20211023
  33. ★, X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19, Sci. Immunol, 6(11), eabl14348, 20210820
  34. Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency, J Exp Med, 218(11), e20210566, 20210816
  35. Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia, J Clin Invest, 131(15), e152474, 20210802
  36. ★, Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance, J Exp Med, 218(8), e20202592, 20210518
  37. Inherited CARD9 deficiency in a child with invasive disease due to Exophiala dermatitidis and two older but asymptomatic siblings, J. Clin. Immunol, 41, 975-986, 20210208
  38. ★, Human STAT1 Gain-of-function heterozygous mutations: Chronic Mucocutaneous Candidiasis and type I interferonopathy, J. Clin. Immunol, 40, 1065-1080, 20200827
  39. Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice, Int. Immunol, 32(4), 259-272, 20191223
  40. Gain–of-function IKBKB mutation causes human combined immune deficiency, J Exp Med., 215(11), 2715-2724, 20180924
  41. ★, Enhanced AKT phosphorylation of circulating B cells in patients with activated PI3K delta syndrome, Front Immunol., 9(568), 20180405
  42. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency, Proc Natl Acad Sci U S A., 113(15), E8277-E8285, 20161207
  43. Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome-like immunodeficiency, J Allergy Clin Immunol., 138(6), 1672-1680, 20160714
  44. Clinical and immune phenotype associated with activated phosphorinositide 3 kinase delta syndrome 2: A cohort study, J Allergy Clin Immunol., 138(1), 210-218, 20160421
  45. Effective treatment of childhood blastic plasmacytoid dendritic cell neoplasm with a cutaneous tumor alone by stem cell transplantation with reduced intensity, Indian J Hematol Blood Transfus., 26-31, 20150421

Publications such as books

  1. 2022/05/25, Clinical Immunology & Allergology, 2022, 05, Single work, 日本語, Takaki Asano, 560-567

Invited Lecture, Oral Presentation, Poster Presentation

  1. Impaired STAT1 dephosphorylation and enhanced responses to interferons account for Th17 deficiency in patients with STAT1 gain-of-function, Takaki Asano, Takashi Tanaka, Miyuki Tsumura, Sonoko Sakata, Aya Jodo, Mélanie Migaud, Xiao-Fei Kong, Kunihiko Moriya, Yoko Mizoguchi, Alexandra Y. Kreins, Julie Toubiana, Wie-Te Lei, Cheng-Lung Ku, Bertrand Boisson, Laurent Abel, Jacinta C. Bustamante, Stéphanie Boisson-Dupuis, Federica Sallusto, Jean-Laurent Casanova, Anne Puel, and Satoshi Okada, 21st Biennial Meeting of the Europaen Society for Immunodeficiencies (ESID 2024), 2024/10/16, Without Invitation, English
  2. How to find PIDs (Primary Immunodeficiencies), Takaki Asano, 4th ASIA-PACIFIC SOCIETY FOR IMMUNODEFICIENCIES CONGRESS, 2022/04/01, With Invitation, English, Malaysia
  3. Human STAT3 variants underlie autosomal dominant hyper IgE syndrome by negative dominance., Takaki Asano, Bertrand Boisson, Jean-Laurent Casanova, 2021 NYC Primary Immunodeficiency – Inborn Errors of Immunity Symposium, 2021/01/13, Without Invitation, English, NYC PID meeting, New York
  4. Anti-N-methyl-D-aspartate receptor encephalitis associated with IRAK-4 deficiency, Takaki Asano, IAPIDS Advanced PID school 2020, 2020/01/30, Without Invitation, English, International Alliance of Primary Immunodeficiency Societies, Portugal
  5. Anti-N-methyl-D-aspartate receptor encephalitis associated with IRAK-4 deficiency, Takaki Asano, Shiho Nishimura, Yoshiyuki Kobayashi, Miyuki Tsumura, Nobutsune Ishikawa, Hidenori Ohnishi, Hidetoshi Takada, Vanessa Snacho-Shimizu, Kunihiko Moriya, Anne Puel, Capucine Picard, Sarosh R Irani, Jean-Laurent Casanova, Satoshi Okada, Masao Kobayashi, 18th Biennial Meeting of the European Society for immunodeficiencies (ESID 2018), 2018/10/24, Without Invitation, English, Portugal
  6. Hematopoietic stem cell transplantation for patients with gain of function in STAT1 mutation, Takaki Asano, Satoshi Okada, Jennifer W. Leiding, Troy R. Thorgerson, Tomohiro Morio, Masao Kobayashi, 2017/10/20, Without Invitation, Japanese, Tokyo
  7. Flow cytometry based simple diagnosis of activated PI3Kdelta syndrome by evaluating pAKT in circulating B cells., Takaki Asano, Miyuki Tsumura, Satoshi Okada, Masao Kobayashi, 17th Biennial Meeting of the European Society for immunodeficiencies (ESID 2016), 2016/09/21, Without Invitation, English, Spain
  8. Excessive phosphorylation of AKT in CD19-positive B cells in patients with Activated PI3Kdelta syndrome, 2016/05/13, Without Invitation, Japanese
  9. Gastric cancer in a patient with primary immune deficiency, Takaki Asano, Asia Pacific Society for Immunodeficiencies (APSID 2016), 2016/05/01, Without Invitation, English, Hong Kong
  10. The detection of excess AKT phosphorylation by flow cytometry in patients with activated PI3Kdelta syndrome, Takaki Asano, Miyuki Tsumura, Satoshi Okada, Masao Kobayashi, 2015/11/18, Without Invitation, Japanese, Sapporo
  11. Successful HSCT with non-irradiation conditioning regimen with 3 infant cases of FHL, Takaki Asano, Yasuhiko Sera, Maiko Shimomura, Aya Furue, Ikue Chijimatsu, Mizuka Miki, Hiroshi Kawaguchi, Kazuhiro Nakamura, Masao Kobayashi, 2012/10/19, Without Invitation, Japanese, Kyoto

Awards

  1. 2016/09/23, ESID2016 Best E-poster award, The European Society for Immunodeficiencies (ESID), Flow cytometry based simple diagnosis of activated PI3Kdelta syndrome by evaluating pAKT in circulating B cells