YOKO MIZOGUCHI

Last Updated :2024/05/15

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Assistant Professor
E-mail
ymizoguchhiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Hiroshima University, 2014
  • Hiroshima University, 2003

Academic Degrees

  • Hiroshima University

Research Keywords

  • Congenital neutropenia

Affiliated Academic Societies

  • Japan pediatric society
  • Japanese society of hematology
  • The Japanese society of Pediatric Hematology/Oncology
  • The Japanese Society on Thrombosis and Hemostasis
  • The Japan Society of Transfusion Medicine and Cell Therapy
  • JSIAD
  • The Japan society for hamatopoietic cell transplantation
  • the Japan society of human genetics

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Systemic Disease Control
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2024, Undergraduate Education, 2Term, Pediatrics
  4. 2024, Undergraduate Education, 2Term, Pediatrics

Research Activities

Academic Papers

  1. Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity, JOURNAL OF EXPERIMENTAL MEDICINE, 220(9), 20230605
    Link to Paper Search Results by DOI
  2. Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, COMMUNICATIONS BIOLOGY, 6(1), 20230411
    Link to Paper Search Results by DOI
  3. ★, Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes, BLOOD, 141(6), 645-658, 20230209
    Link to Paper Search Results by DOI
  4. Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19, JOURNAL OF CLINICAL IMMUNOLOGY, 42(7), 1360-1370, 202210
    Link to Paper Search Results by DOI
  5. Mendelian susceptibility to mycobacterial diseases: state of the art, CLINICAL MICROBIOLOGY AND INFECTION, 28(11), 1429-1434, 202211
    Link to Paper Search Results by DOI
  6. Human T-bet governs the generation of a distinct subset of CD11c(high)CD21(low) B cells, SCIENCE IMMUNOLOGY, 7(73), 202207
    Link to Paper Search Results by DOI
  7. HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation, JOURNAL OF CLINICAL INVESTIGATION, 132(9), 20220502
    Link to Paper Search Results by DOI
  8. Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-gamma, J Allergy Clin Immunol., 2021
  9. Inborn Errors of STAT1 Immunity, Curr Opin Immunol., 72, 59-64, 2021
  10. Inherited CARD9 Deficiency in a Child with Invasive Disease Due to Exophiala dermatitidis and Two Older but Asymptomatic Siblings, JOURNAL OF CLINICAL IMMUNOLOGY, 41(5), 975-986, 2021
    Link to Paper Search Results by DOI
  11. Mammalian VPS45 orchestrates trafficking through the endosomal system, BLOOD, 2020
    Link to Paper Search Results by DOI
  12. IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation, JOURNAL OF CLINICAL IMMUNOLOGY, 2020
  13. Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutations, INTERNATIONAL IMMUNOLOGY, 32(10), 663-671, 2020
  14. Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells, Journal of Clinical Immunology, 39(4), 391-400, 20190515
  15. Neutropenia (In infancy and childhood), Hematological Disorders in Children: Pathogenesis and Treatment, 109-113, 20170614
  16. Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 137(2), 619-622, 2016
  17. Early eradication of factor VIII inhibitor in patients with congenital hemophilia A by immune tolerance induction with a high dose of immunoglobulin, INTERNATIONAL JOURNAL OF HEMATOLOGY, 103(4), 473-477, 2016
    Link to Paper Search Results by DOI
  18. ★, Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis, JOURNAL OF LEUKOCYTE BIOLOGY, 95(4), 667-676, 2014
    Link to Paper Search Results by DOI
  19. Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(8), 3023-3028, 2013
    Link to Paper Search Results by DOI
  20. Management of advanced-stage neuroblastoma in a patient with 21-hydroxalase deficiency, PEDIATRICS INTERNATIONAL, 55(4), E96-E99, 2013
  21. A Case of Neonatal Coxsackie B2 Meningo-Encephalitis in which Serial Magnetic Resonance Imaging Findings Reveal the Development of Lesions, NEUROPEDIATRICS, 42(4), 156-158, 2011
  22. Decreased Expression in Nuclear Factor-kappa B Essential Modulator Due to a Novel Splice-Site Mutation Causes X-linked Ectodermal Dysplasia with Immunodeficiency, JOURNAL OF CLINICAL IMMUNOLOGY, 31(5), 762-772, 2011
  23. Significance of immature platelet fraction and CD41-positive cells at birth in early onset neonatal thrombocytopenia, INTERNATIONAL JOURNAL OF HEMATOLOGY, 91(2), 245-251, 2010
  24. ★, Juvenile myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98-HOXA11 fusion, AMERICAN JOURNAL OF HEMATOLOGY, 84(5), 295-297, 2009
    Link to Paper Search Results by DOI
  25. Deficiency of regulatory T cells in children with autoimmune neutropenia, BRITISH JOURNAL OF HAEMATOLOGY, 145(5), 642-647, 2009
  26. Steroid-dependent ACTH-produced thymic carcinoid: Regulation of POMC gene expression by cortisol via methylation of its promoter region, HORMONE RESEARCH, 67(5), 257-262, 2007
  27. A case of adolescent primary adrenal natural killer cell lymphoma, INTERNATIONAL JOURNAL OF HEMATOLOGY, 81(4), 330-334, 2005

Invited Lecture, Oral Presentation, Poster Presentation

  1. Consecutive US examination revealed a significance of joint evaluation on preventing joint disease in pediatric patients with hemophilia., Yoko Mizoguchi, Chihiro Tani, Keita Tomioka, Maiko Shimomura, Shiho Nishimura, Yoshiko Matsubara, Hiroshi Kawaguchi, Yuko Nakashima, Satoshi Okada and Masao Kobayashi, 2022/11/25, Without Invitation, Japanese
  2. The efficacy of continuous US evaluation for joint health in pediatric patients with hemophilia, Yoko Mizoguchi, Chihiro Tani, Shiho Nishimura, Keiko Matsubara, Keita Tomioka, Maiko Shimomura, Yuko Nakashima, Hiroshi Kawaguchi, Satoshi Okada and Masao Kobayashi, 2021/09/23, Without Invitation, English
  3. Neutropenia caused by monogenic defects of the Signal Recognition Particle (SRP) complex, Yoko Mizoguchi, Sebastian Hesse, Monika Linder, Natalia Zietara, Marcin Lyszkiewicz, Yanshan Liu, Megumi Tatematsu, Piotr Grabowsky, Tim Jeske, Sebastian Hollizeck, Ejona Rusha, Zahra Alizadeh, Zahra Pourpak, Sorin Iurian, Nima Razaei, Ekrem Unal, Micha Drukker, Barbara Walzog, Fabian Hauck, Megumu Saito, Satoshi Okada, Masao Kobayashi, Juri Rappsilber, Christoph Klein, 2021/02/06, Without Invitation, Japanese
  4. Proteotypic imbalances in neutrophil granulocytes with monogenic disorders associated with congenital neutropenia, 2020/11/20, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2023, 2023
  2. 2023, 2025
  3. Development of stem cell gene therapy for Severe Congenital Neutropenia (SCN), 2021, 2025
  4. 2021, 2023
  5. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2021, 2022
  6. Development of early prediction system for the risk of severe COVID-19 by measuring autoantibodies against type I interferons, 2021, 2021
  7. 2015, 2015