NAOTO FUJITA
Last Updated :2025/02/03
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Health Sciences), Professor
- E-mail
- fujitan
hiroshima-u.ac.jp
- Self-introduction
- 1. Physiological adaptations of motor system to metabolic disease, inactivity, and exercise
We are investigating novel treatment to reinforce the effectiveness of exercise. Main targets of the treatment are skeletal muscle, adipose tissue, liver, pancreas, and brain. We have reported the influences of exercise in skeletal muscle regeneration, inactivity, pulmonary hypertension, diabetes, and obesity.
2. Complementary and alternative treatments in severe disease with inactivity
Exercise to some disorder with inactivity is widely accepted as a method to promote improvement of motor dysfunction. Although the effectiveness of exercise in the treatment of various medical condition is proven and established, many patients dislike physical activity and this therapeutic exercise is often inconsistently practiced. We have reported the influences of hyperbaric treatment as complementary and alternative treatments in skeletal muscle regeneration and diabetes with obesity.
3. Physical exercise with biomedical sensors
The purpose of this study is development of motion coaching system by using artificial inteligence (AI). Automated motion analysis by biomedical sensors could detect modifications and improve exercise performance. We believe that this development could depend on resolution of children's dislike for physical activity.
Basic Information
Major Professional Backgrounds
- 2010/04/01, 2013/03/31, Kobe University, Assistant Professor
- 2013/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Lecturer
Academic Degrees
- Doctor of Philosophy in Health Science, Kobe University
- Master of Health Science, Kobe University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Health Sciences : Physical Therapy
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
Affiliated Academic Societies
- The Japan Endocrine Society
- Japan Society for the Study of Obesity
- Japanese Physical Therapy Association
- The Japanese Association of Anatomists
- Japanese Society of Physical Fitness and Sports Medicine
- Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine
- The Physiological Society of Japan
- American Physiological Society
Educational Activity
Course in Charge
- 2024, Liberal Arts Education Program1, 4Term, Human health and the society
- 2024, Undergraduate Education, Second Semester, Human Development
- 2024, Undergraduate Education, Second Semester, Developmental Disorders in Childhood
- 2024, Undergraduate Education, 1Term, Basic Physical Therapy
- 2024, Undergraduate Education, Second Semester, Functional Assessment of Physical Therapy
- 2024, Undergraduate Education, First Semester, Functional Assessment of Physical Therapy (Practice)
- 2024, Undergraduate Education, Second Semester, Physical Agents
- 2024, Undergraduate Education, 1Term, Physical Agents Practicum
- 2024, Undergraduate Education, Second Semester, Graduation Theses
- 2024, Undergraduate Education, First Semester, Anatomy I
- 2024, Undergraduate Education, First Semester, Anatomy I
- 2024, Undergraduate Education, Second Semester, Anatomy II
- 2024, Undergraduate Education, Second Semester, Anatomy II
- 2024, Undergraduate Education, 2Term, Practice of Anatomy I
- 2024, Undergraduate Education, 2Term, Practice of Anatomy I
- 2024, Undergraduate Education, Second Semester, Practice of Anatomy II
- 2024, Undergraduate Education, Second Semester, Practice of Anatomy II
- 2024, Undergraduate Education, Second Semester, Neuro and Physical Development
- 2024, Undergraduate Education, Intensive, Clinical Practice I
- 2024, Undergraduate Education, Second Semester, Developmental disorder
- 2024, Undergraduate Education, 4Term, Principles of Rehabilitation
- 2024, Graduate Education (Master's Program) , First Semester, Advanced Lecture on Health Science 3(Experiment Research)
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
- 2024, Graduate Education (Master's Program) , First Semester, Lecture on Bio-Environmental Adaptation Sciences
- 2024, Graduate Education (Master's Program) , First Semester, Seminar on Bio-Environmental Adaptation Sciences
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Bio-Environmental Adaptation Sciences
- 2024, Graduate Education (Master's Program) , Year, Research on Bio-Environmental Adaptation Sciences
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Bio-Environmental Adaptation Sciences
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Bio-Environmental Adaptation Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Bio-Environmental Adaptation Sciences
Research Activities
Academic Papers
- Influence of prolonged obesity and mild glucose intolerance on skeletal muscle mass in middle-aged rats, JJPTDM, 2(1), 1-15, 202301
- Effects of childhood exercise and detraining on skeletal muscle mitochondrial metabolism in young OLETF rats, JJPTDM, 2(1), 24-34, 202301
- Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs, PLoS One, 17, e0270330-e0270330, 2022
- Structural changes in skeletal muscle fibers after icing or heating on downhill running in mice, Kobe J Med Sci, 67(2), 48-54-48-54, 2021
- Coupled versus decoupled visuomotor feedback: Differential frontoparietal activity during curved reach planning on simultaneous functional near-infrared spectroscopy and electroencephalography, BRAIN AND BEHAVIOR, 12(7), 202207
- Voluntary exercise reverses social behavior deficits and the increases in the densities of cholecystokinin-positive neurons in specific corticolimbic regions of diabetic OLETF rats, BEHAVIOURAL BRAIN RESEARCH, 428, 20220625
- Involvement of the Rostromedial Prefrontal Cortex in Human-Robot Interaction: fNIRS Evidence From a Robot-Assisted Motor Task, FRONTIERS IN NEUROROBOTICS, 16, 20220317
- Preventive effect of nucleoprotein on hindlimb unloading-induced capillary regression in rat soleus muscle, BIOTECHNIC & HISTOCHEMISTRY, 89(3), 220-227, 201404
- Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat., Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat., 116(7), 1192-1198, 2014
- Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration., Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration., 9(12), 2014
- Influence of electrical stimulation on calpain and ubiquitin-proteasome systems in the denervated and unloaded rat tibialis anterior muscles, Acta Histochem, 116, 936-942, 2014
- Effect of heat stress soon after muscle injury on the expression of MyoD and myogenin during regeneration process. J Musculoskelet Neuronal Interact, J Musculoskelet Neuronal Interact, 14, 325-333, 2014
- Balance ability and proprioception after single bundle, single-bundle augmentation, and double-bundle ACL reconstruction, Scientific World Journal, 2014
- Time course of ubiquitin-proteasome and macroautophagy-lysosome pathways in skeletal muscle in rats with heart failure, BIOMEDICAL RESEARCH-TOKYO, 36(6), 383-392, 2015
- Effectiveness of daily eccentric contractions induced via kilohertz frequency transcutaneous electrical stimulation on muscle atrophy, ACTA HISTOCHEMICA, 118(1), 56-62, 2016
- Acute influence of mild hyperbaric oxygen at 1.25 atmospheres absolute with normal air on mitochondrial enzymes and PGC-1 alfa mRNA levels in rat skeletal muscle, Biomed Res Clin Prac, 1, 42-45, 2016
- Knee biomechanics during walking in recurrent lateral patellar dislocation are normalized by one year after medial patellofemoral ligament reconstruction, Knee Surg Sports Traumatol Arthrosc, 24, 3254-3261, 2016
- Modarate exercise attenuated airway resistance and inflammation induced by cigarette smoke solution and endotoxin in rats, Sport Sci Health, 12, 91-97, 2016
- Heat stress promotes skeletal muscle regeneration after crush injury in rats, Acta Histochem, 116, 327-334, 2014
- Comparison of premodulated interferential and pulsed current electrical stimulation in prevention of deep muscle atrophy in rats, J Mol Histo, 44, 203-211, 2013
- Differential effects of astaxanthin on oxidative key enzyme and capillarization in the deep and superficial layers of unloading-induced atrophied muscle, J Phys Ther Sci, 25, 349-353, 2013
- Protective effects of astaxanthin on capillary regression in atrophied soleus muscle of rats, Acta Physiol, 207, 405-415, 2013
- Chronic Exercise Training Down-Regulates TNF-alpha and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading, Acta Histochem Cytochem, 45, 343-349, 2012
- Abnormalities in the fiber composition and capillary architecture in the soleus muscle of type 2 diabetic Goto-Kakizaki rats, ScientificWorldJournal, 2012
- Differences in capillary architecture, hemodynamics, and angiogenic factors in rat slow and fast plantarflexor muscles, Muscle Nerve, 45, 242-249, 2012
- Exercise training prevents decrease in luminal capillary diameter of skeletal muscles in rats with type 2 diabetes, ScientificWorldJournal, 2012
- Influence of magnetic stimulation on muscle atrophy in the rat unloading hindlimb muscles, Bulletin of Health Sciences Kobe, 27, 19-26, 2012
- Effects of hyperbaric oxygen on metabolic capacity of the skeletal muscle in type 2 diabetic rats with obesity, ScientificWorldJournal, 2011
- Influence of icing on muscle regeneration after crush injury to skeletal muscles in rats, J Appl Physiol, 110, 382-388, 2011
- The combined effect of electrical stimulation and high-load isometric contraction on protein degradation pathways in muscle atrophy induced by hindlimb unloading, J Biomed Biotechnol, 2011
- The combined effect of electrical stimulation and resistance isometric contraction on muscle atrophy in rat tibialis anterior muscle, Bosn J Basic Med Sci, 11, 74-79, 2011
- Influence of fixed muscle length and contractile properties on atrophy and subsequent recovery in the rat soleus and plantaris muscles, Arch Histol Cytol, 72, 151-163, 2009
- Influence of muscle length on muscle atrophy in the mouse tibialis anterior and soleus muscles, Biomed Res, 30, 39-45, 2009
- Gender differences in the restoration of knee joint biomechanics during gait after anterior cruciate ligament reconstruction, KNEE, 24(2), 280-288, 201703
- Effects of lateral wedge insole application on medial compartment knee osteoarthritis severity evaluated by ultrasound, KNEE, 24(6), 1408-1413, 201712
- Characteristics of thoracic and lumbar movements during gait in lumbar spinal stenosis patients before and after decompression surgery, Clin Biomedch 40: 45-51, 40, 45-51, 2017
- Validity of motion analysis using the Kinect system to evaluate single leg stance in patients with hip disorders, GAIT & POSTURE, 62, 458-462, 201805
- Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia, PLOS ONE, 13(5), 20180502
- Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension, PLoS One, 13, 2018
- Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension, PLOS ONE, 13(9), 20180920
- The Relationship between Knee Biomechanics and Clinical Assessments in ACl Deficient Patients, INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 40(7), 477-483, 201907
- Hyperbaric Normoxia Improved Glucose Metabolism and Decreased Inflammation in Obese Diabetic Rat, JOURNAL OF DIABETES RESEARCH, 2019, 20191119
- Effects of appropriate-intensity treadmill exercise on skeletal muscle and respiratory functions in a rat model of emphysema, BIOMEDICAL RESEARCH-TOKYO, 41(1), 13-22, 2020
- Hemodynamic response during hyperbaric treatment on skeletal muscle in a type 2 diabetes rat model, BIOMEDICAL RESEARCH-TOKYO, 41(1), 23-32, 2020
- Region-specific brain area reductions and increased cholecystokinin positive neurons in diabetic OLETF rats: implication for anxiety-like behavior, JOURNAL OF PHYSIOLOGICAL SCIENCES, 70(1), 20200916
- Structural changes in skeletal muscle fibers after icing or heating on downhill running in mice, Kobe Journal of Medical Sciences, 67(2), 2021
- Medial prefrontal area reductions, altered expressions of cholecystokinin, parvalbumin, and activating transcription factor 4 in the corticolimbic system, and altered emotional behavior in a progressive rat model of type 2 diabetes., PLoS One, 2021
- Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity, METABOLITES, 11(10), 202110
- Medial prefrontal area reductions, altered expressions of cholecystokinin, parvalbumin, and activating transcription factor 4 in the corticolimbic system, and altered emotional behavior in a progressive rat model of type 2 diabetes, PLOS ONE, 16(9), 2021
Invited Lecture, Oral Presentation, Poster Presentation
- Time course of fat accumulation in various organs of young OLETF rats, Sakakura K, Nishihira M, Iwamoto Y, Yamamoto Y, Fujita N, Urakawa S, Experimental Biology 2022, 2022/04/02, Without Invitation, English
- Histological infuluences of food restriction on brown adipose tissue in young OLETF rats, Nishihira M, Nguyen ST, Nagamori K, Fujita N, Urakawa S, Experimental Biology 2022, 2022/04/02, Without Invitation, English
- Influences of exrcise and detraining during childhood on brown adipose tissue whitening in OLETF rats, Takaishi K, Oshima T, Ochi R, Nishihira M, Eto H, Fujita N, Urakawa S., Takaishi K, Oshima T, Ochi R, Nishihira M, Eto H, Fujita N, Urakawa S., Experimental Biology 2021, 2021/04/27, Without Invitation, English, Experimental Biology 2021
- Influences of childhood exercise on adipose tissue browning in OLETF rats, Oshima T, Takaishi K, Nishihira M, Eto H, Fujita N, Urakawa S, Oshima T, Takaishi K, Nishihira M, Eto H, Fujita N, Urakawa S, Experimental Biology 2021, 2021/04/27, Without Invitation, English, Experimental Biology 2021
- Effects of exercise on browning of adipose tissue in OLETF rat, Nishihira M, Eto H, Oshima T, Takaishi K, Fujita N, Urakawa S, Nishihira M, Eto H, Oshima T, Takaishi K, Fujita N, Urakawa S, Experimental Biology 2021, 2021/04/27, Without Invitation, English, Experimental Biology 2021
- Time course of fat accumulation in various organs of young OLETF rats, Sakakura K, Nishihira M, Iwamoto Y, Yamamoto Y, Fujita N, Urakawa S., Sakakura K, Nishihira M, Iwamoto Y, Yamamoto Y, Fujita N, Urakawa S., 2022/04/02, Without Invitation, English, Experimental Biology 2022
- Histological infuluences of food restriction on brown adipose tissue in young OLETF rats, Nishihira M, Nguyen ST, Nagamori K, Fujita N, Urakawa S, 2022/04/02, Without Invitation, English, Experimental Biology 2022
- Parvalbumin positive neurons in the basolateral amygdala and anxiety-like behavior in OLETF rats., Ochi R, Fujita N, Goto N, Nisijo H, Urakawa S., 9th Federation of the Asian and Oceanian Physiological Sciences Congress., 2019, Without Invitation, English
- Hemodynamic responses to hyperbaric treatment in skeletal muscle of obesity and type 2 diabetes rats., Goto N, Fujita N, Nino W, Hisatsune K, Ochi R, Nisijo H, Urakawa S., 9th Federation of the Asian and Oceanian Physiological Sciences Congress., 2019, Without Invitation, English
- Hyperbaric treatment with normal air prevents the progression of hyperglycemia in type 2 diabetes., Goto N, Fujita N, Nino W, Hisatsune K, Ochi R, Nisijo H, Urakawa S., ACSMs 66th annual meeting, 2019/06/01, Without Invitation, English, Florida
External Funds
Acceptance Results of Competitive Funds
- 2022
- 2022, 2022
- KAKENHI, 2016, 2018
- KAKENHI, 2013, 2014
- KAKENHI, 2013, 2015
- KAKENHI, Effect of exercise to capillary degradation and sarcopenia by aging, 2011, 2012
- KAKENHI, Effect of implanted electrical stimulation on skeletal muscle atrophy in heart failure, 2011, 2012
- 2010, 2011
- KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021
Social Activities
Organizing Academic Conferences, etc.
- 2018/12
History as Peer Reviews of Academic Papers
- 2022, Journal of Applied Physiology, Others
- 2021, Aging and Disease
- 2021, International journal of molecular sciences, Others
- 2021, European journal of sports science, Others
- 2020, Histochemistry and Cell Biology, Others, referee, 1
- 2019, PLoS One, Others
- 2019, Cell Signal, Others
- 2019, Clin Interv Agin, Others
- 2019, J Orthop Res, Others
- 2016, Muscle and Nerve, Others, 1
- 2016, Journal of Back and Musculoskeletal Rehabilitation, Others
- 2017, Scientific Reports, Others
- 2017, J Orthop Res, Others
- 2017, General Physiology and Biophysics, Others