NAOTO FUJITA

Last Updated :2024/02/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Health Sciences), Professor
E-mail
fujitanhiroshima-u.ac.jp
Self-introduction
1. Physiological adaptations of motor system to metabolic disease, inactivity, and exercise We are investigating novel treatment to reinforce the effectiveness of exercise. Main targets of the treatment are skeletal muscle, adipose tissue, liver, pancreas, and brain. We have reported the influences of exercise in skeletal muscle regeneration, inactivity, pulmonary hypertension, diabetes, and obesity. 2. Complementary and alternative treatments in severe disease with inactivity Exercise to some disorder with inactivity is widely accepted as a method to promote improvement of motor dysfunction. Although the effectiveness of exercise in the treatment of various medical condition is proven and established, many patients dislike physical activity and this therapeutic exercise is often inconsistently practiced. We have reported the influences of hyperbaric treatment as complementary and alternative treatments in skeletal muscle regeneration and diabetes with obesity. 3. Physical exercise with biomedical sensors The purpose of this study is development of motion coaching system by using artificial inteligence (AI). Automated motion analysis by biomedical sensors could detect modifications and improve exercise performance. We believe that this development could depend on resolution of children's dislike for physical activity.

Basic Information

Major Professional Backgrounds

  • 2010/04/01, 2013/03/31, Kobe University, Assistant Professor
  • 2013/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Lecturer

Academic Degrees

  • Doctor of Philosophy in Health Science, Kobe University
  • Master of Health Science, Kobe University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Health Sciences : Physical Therapy
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Health Sciences

Affiliated Academic Societies

  • The Japan Endocrine Society
  • Japan Society for the Study of Obesity
  • Japanese Physical Therapy Association
  • The Japanese Association of Anatomists
  • Japanese Society of Physical Fitness and Sports Medicine
  • Japanese Orthopaedic Society of Knee,Arthroscopy and Sports Medicine
  • The Physiological Society of Japan
  • American Physiological Society

Educational Activity

Course in Charge

  1. 2023, Liberal Arts Education Program1, 4Term, Human health and the society
  2. 2023, Undergraduate Education, Second Semester, Human Development
  3. 2023, Undergraduate Education, Second Semester, Developmental Disorders in Childhood
  4. 2023, Undergraduate Education, Second Semester, Functional Assessment of Physical Therapy
  5. 2023, Undergraduate Education, Second Semester, Physical Agents
  6. 2023, Undergraduate Education, 1Term, Physical Agents Practicum
  7. 2023, Undergraduate Education, Intensive, Integrated Clinical Affiliation
  8. 2023, Undergraduate Education, First Semester, Anatomy I
  9. 2023, Undergraduate Education, First Semester, Anatomy I
  10. 2023, Undergraduate Education, Second Semester, Anatomy II
  11. 2023, Undergraduate Education, Second Semester, Anatomy II
  12. 2023, Undergraduate Education, 2Term, Practice of Anatomy I
  13. 2023, Undergraduate Education, 2Term, Practice of Anatomy I
  14. 2023, Undergraduate Education, Second Semester, Practice of Anatomy II
  15. 2023, Undergraduate Education, Second Semester, Practice of Anatomy II
  16. 2023, Undergraduate Education, Second Semester, Neuro and Physical Development
  17. 2023, Undergraduate Education, Intensive, Clinical Practice III
  18. 2023, Undergraduate Education, Second Semester, Developmental disorder
  19. 2023, Undergraduate Education, 4Term, Principles of Rehabilitation
  20. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Development of Physical Therapy and Occupational Therapy Sciences
  21. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Musculoskeletal Functional Research and Regeneration
  22. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Musculoskeletal Functional Research and Regeneration
  23. 2023, Graduate Education (Master's Program) , Second Semester, Seminar on Bio-Environmental Adaptation Sciences
  24. 2023, Graduate Education (Master's Program) , Year, Research on Bio-Environmental Adaptation Sciences
  25. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Bio-Environmental Adaptation Sciences

Research Activities

Academic Papers

  1. Influence of prolonged obesity and mild glucose intolerance on skeletal muscle mass in middle-aged rats, JJPTDM, 2(1), 1-15, 202301
  2. Effects of childhood exercise and detraining on skeletal muscle mitochondrial metabolism in young OLETF rats, JJPTDM, 2(1), 24-34, 202301
  3. Effects of long-term childhood exercise and detraining on lipid accumulation in metabolic-related organs, PLoS One, 17, e0270330-e0270330, 2022
  4. Structural changes in skeletal muscle fibers after icing or heating on downhill running in mice, Kobe J Med Sci, 67(2), 48-54-48-54, 2021
  5. Coupled versus decoupled visuomotor feedback: Differential frontoparietal activity during curved reach planning on simultaneous functional near-infrared spectroscopy and electroencephalography, BRAIN AND BEHAVIOR, 12(7), 202207
  6. Voluntary exercise reverses social behavior deficits and the increases in the densities of cholecystokinin-positive neurons in specific corticolimbic regions of diabetic OLETF rats, BEHAVIOURAL BRAIN RESEARCH, 428, 20220625
  7. Involvement of the Rostromedial Prefrontal Cortex in Human-Robot Interaction: fNIRS Evidence From a Robot-Assisted Motor Task, FRONTIERS IN NEUROROBOTICS, 16, 20220317
  8. Preventive effect of nucleoprotein on hindlimb unloading-induced capillary regression in rat soleus muscle, BIOTECHNIC & HISTOCHEMISTRY, 89(3), 220-227, 201404
  9. Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat., Electrical stimulation using sine waveform prevents unloading-induced muscle atrophy in the deep calf muscles of rat., 116(7), 1192-1198, 2014
  10. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration., Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration., 9(12), 2014
  11. Influence of electrical stimulation on calpain and ubiquitin-proteasome systems in the denervated and unloaded rat tibialis anterior muscles, Acta Histochem, 116, 936-942, 2014
  12. Effect of heat stress soon after muscle injury on the expression of MyoD and myogenin during regeneration process. J Musculoskelet Neuronal Interact, J Musculoskelet Neuronal Interact, 14, 325-333, 2014
  13. Balance ability and proprioception after single bundle, single-bundle augmentation, and double-bundle ACL reconstruction, Scientific World Journal, 2014
  14. Time course of ubiquitin-proteasome and macroautophagy-lysosome pathways in skeletal muscle in rats with heart failure, BIOMEDICAL RESEARCH-TOKYO, 36(6), 383-392, 2015
  15. Effectiveness of daily eccentric contractions induced via kilohertz frequency transcutaneous electrical stimulation on muscle atrophy, ACTA HISTOCHEMICA, 118(1), 56-62, 2016
  16. Acute influence of mild hyperbaric oxygen at 1.25 atmospheres absolute with normal air on mitochondrial enzymes and PGC-1 alfa mRNA levels in rat skeletal muscle, Biomed Res Clin Prac, 1, 42-45, 2016
  17. Knee biomechanics during walking in recurrent lateral patellar dislocation are normalized by one year after medial patellofemoral ligament reconstruction, Knee Surg Sports Traumatol Arthrosc, 24, 3254-3261, 2016
  18. Modarate exercise attenuated airway resistance and inflammation induced by cigarette smoke solution and endotoxin in rats, Sport Sci Health, 12, 91-97, 2016
  19. Heat stress promotes skeletal muscle regeneration after crush injury in rats, Acta Histochem, 116, 327-334, 2014
  20. Comparison of premodulated interferential and pulsed current electrical stimulation in prevention of deep muscle atrophy in rats, J Mol Histo, 44, 203-211, 2013
  21. Differential effects of astaxanthin on oxidative key enzyme and capillarization in the deep and superficial layers of unloading-induced atrophied muscle, J Phys Ther Sci, 25, 349-353, 2013
  22. Protective effects of astaxanthin on capillary regression in atrophied soleus muscle of rats, Acta Physiol, 207, 405-415, 2013
  23. Chronic Exercise Training Down-Regulates TNF-alpha and Atrogin-1/MAFbx in Mouse Gastrocnemius Muscle Atrophy Induced by Hindlimb Unloading, Acta Histochem Cytochem, 45, 343-349, 2012
  24. Abnormalities in the fiber composition and capillary architecture in the soleus muscle of type 2 diabetic Goto-Kakizaki rats, ScientificWorldJournal, 2012
  25. Differences in capillary architecture, hemodynamics, and angiogenic factors in rat slow and fast plantarflexor muscles, Muscle Nerve, 45, 242-249, 2012
  26. Exercise training prevents decrease in luminal capillary diameter of skeletal muscles in rats with type 2 diabetes, ScientificWorldJournal, 2012
  27. Influence of magnetic stimulation on muscle atrophy in the rat unloading hindlimb muscles, Bulletin of Health Sciences Kobe, 27, 19-26, 2012
  28. Effects of hyperbaric oxygen on metabolic capacity of the skeletal muscle in type 2 diabetic rats with obesity, ScientificWorldJournal, 2011
  29. Influence of icing on muscle regeneration after crush injury to skeletal muscles in rats, J Appl Physiol, 110, 382-388, 2011
  30. The combined effect of electrical stimulation and high-load isometric contraction on protein degradation pathways in muscle atrophy induced by hindlimb unloading, J Biomed Biotechnol, 2011
  31. The combined effect of electrical stimulation and resistance isometric contraction on muscle atrophy in rat tibialis anterior muscle, Bosn J Basic Med Sci, 11, 74-79, 2011
  32. Influence of fixed muscle length and contractile properties on atrophy and subsequent recovery in the rat soleus and plantaris muscles, Arch Histol Cytol, 72, 151-163, 2009
  33. Influence of muscle length on muscle atrophy in the mouse tibialis anterior and soleus muscles, Biomed Res, 30, 39-45, 2009
  34. Gender differences in the restoration of knee joint biomechanics during gait after anterior cruciate ligament reconstruction, KNEE, 24(2), 280-288, 201703
  35. Effects of lateral wedge insole application on medial compartment knee osteoarthritis severity evaluated by ultrasound, KNEE, 24(6), 1408-1413, 201712
  36. Characteristics of thoracic and lumbar movements during gait in lumbar spinal stenosis patients before and after decompression surgery, Clin Biomedch 40: 45-51, 40, 45-51, 2017
  37. Validity of motion analysis using the Kinect system to evaluate single leg stance in patients with hip disorders, GAIT & POSTURE, 62, 458-462, 201805
  38. Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia, PLOS ONE, 13(5), 20180502
  39. Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension, PLoS One, 13, 2018
  40. Oxygen therapy may worsen the survival rate in rats with monocrotaline-induced pulmonary arterial hypertension, PLOS ONE, 13(9), 20180920
  41. The Relationship between Knee Biomechanics and Clinical Assessments in ACl Deficient Patients, INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 40(7), 477-483, 201907
  42. Hyperbaric Normoxia Improved Glucose Metabolism and Decreased Inflammation in Obese Diabetic Rat, JOURNAL OF DIABETES RESEARCH, 2019, 20191119
  43. Effects of appropriate-intensity treadmill exercise on skeletal muscle and respiratory functions in a rat model of emphysema, BIOMEDICAL RESEARCH-TOKYO, 41(1), 13-22, 2020
  44. Hemodynamic response during hyperbaric treatment on skeletal muscle in a type 2 diabetes rat model, BIOMEDICAL RESEARCH-TOKYO, 41(1), 23-32, 2020
  45. Region-specific brain area reductions and increased cholecystokinin positive neurons in diabetic OLETF rats: implication for anxiety-like behavior, JOURNAL OF PHYSIOLOGICAL SCIENCES, 70(1), 20200916
  46. Structural changes in skeletal muscle fibers after icing or heating on downhill running in mice, Kobe Journal of Medical Sciences, 67(2), 2021
  47. Medial prefrontal area reductions, altered expressions of cholecystokinin, parvalbumin, and activating transcription factor 4 in the corticolimbic system, and altered emotional behavior in a progressive rat model of type 2 diabetes., PLoS One, 2021
  48. Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity, METABOLITES, 11(10), 202110
  49. Medial prefrontal area reductions, altered expressions of cholecystokinin, parvalbumin, and activating transcription factor 4 in the corticolimbic system, and altered emotional behavior in a progressive rat model of type 2 diabetes, PLOS ONE, 16(9), 2021

Invited Lecture, Oral Presentation, Poster Presentation

  1. Time course of fat accumulation in various organs of young OLETF rats, Sakakura K, Nishihira M, Iwamoto Y, Yamamoto Y, Fujita N, Urakawa S, Experimental Biology 2022, 2022/04/02, Without Invitation, English
  2. Histological infuluences of food restriction on brown adipose tissue in young OLETF rats, Nishihira M, Nguyen ST, Nagamori K, Fujita N, Urakawa S, Experimental Biology 2022, 2022/04/02, Without Invitation, English
  3. Influences of exrcise and detraining during childhood on brown adipose tissue whitening in OLETF rats, Takaishi K, Oshima T, Ochi R, Nishihira M, Eto H, Fujita N, Urakawa S., Takaishi K, Oshima T, Ochi R, Nishihira M, Eto H, Fujita N, Urakawa S., Experimental Biology 2021, 2021/04/27, Without Invitation, English, Experimental Biology 2021
  4. Influences of childhood exercise on adipose tissue browning in OLETF rats, Oshima T, Takaishi K, Nishihira M, Eto H, Fujita N, Urakawa S, Oshima T, Takaishi K, Nishihira M, Eto H, Fujita N, Urakawa S, Experimental Biology 2021, 2021/04/27, Without Invitation, English, Experimental Biology 2021
  5. Effects of exercise on browning of adipose tissue in OLETF rat, Nishihira M, Eto H, Oshima T, Takaishi K, Fujita N, Urakawa S, Nishihira M, Eto H, Oshima T, Takaishi K, Fujita N, Urakawa S, Experimental Biology 2021, 2021/04/27, Without Invitation, English, Experimental Biology 2021
  6. Time course of fat accumulation in various organs of young OLETF rats, Sakakura K, Nishihira M, Iwamoto Y, Yamamoto Y, Fujita N, Urakawa S., Sakakura K, Nishihira M, Iwamoto Y, Yamamoto Y, Fujita N, Urakawa S., 2022/04/02, Without Invitation, English, Experimental Biology 2022
  7. Histological infuluences of food restriction on brown adipose tissue in young OLETF rats, Nishihira M, Nguyen ST, Nagamori K, Fujita N, Urakawa S, 2022/04/02, Without Invitation, English, Experimental Biology 2022
  8. Parvalbumin positive neurons in the basolateral amygdala and anxiety-like behavior in OLETF rats., Ochi R, Fujita N, Goto N, Nisijo H, Urakawa S., 9th Federation of the Asian and Oceanian Physiological Sciences Congress., 2019, Without Invitation, English
  9. Hemodynamic responses to hyperbaric treatment in skeletal muscle of obesity and type 2 diabetes rats., Goto N, Fujita N, Nino W, Hisatsune K, Ochi R, Nisijo H, Urakawa S., 9th Federation of the Asian and Oceanian Physiological Sciences Congress., 2019, Without Invitation, English
  10. Hyperbaric treatment with normal air prevents the progression of hyperglycemia in type 2 diabetes., Goto N, Fujita N, Nino W, Hisatsune K, Ochi R, Nisijo H, Urakawa S., ACSMs 66th annual meeting, 2019/06/01, Without Invitation, English, Florida

External Funds

Acceptance Results of Competitive Funds

  1. 2022
  2. 2022, 2022
  3. KAKENHI, 2016, 2018
  4. KAKENHI, 2013, 2014
  5. KAKENHI, 2013, 2015
  6. KAKENHI, Effect of exercise to capillary degradation and sarcopenia by aging, 2011, 2012
  7. KAKENHI, Effect of implanted electrical stimulation on skeletal muscle atrophy in heart failure, 2011, 2012
  8. 2010, 2011
  9. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021

Social Activities

Organizing Academic Conferences, etc.

  1. 2018/12

History as Peer Reviews of Academic Papers

  1. 2022, Journal of Applied Physiology, Others
  2. 2021, Aging and Disease
  3. 2021, International journal of molecular sciences, Others
  4. 2021, European journal of sports science, Others
  5. 2020, Histochemistry and Cell Biology, Others, referee, 1
  6. 2019, PLoS One, Others
  7. 2019, Cell Signal, Others
  8. 2019, Clin Interv Agin, Others
  9. 2019, J Orthop Res, Others
  10. 2016, Muscle and Nerve, Others, 1
  11. 2016, Journal of Back and Musculoskeletal Rehabilitation, Others
  12. 2017, Scientific Reports, Others
  13. 2017, J Orthop Res, Others
  14. 2017, General Physiology and Biophysics, Others