TSUTOMU UEDA

Last Updated :2026/01/07

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor
E-mail
uedatsuhiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Otorhinolaryngology

Research Keywords

  • Head Neck Cancer

Affiliated Academic Societies

  • Japan Society of Clinical Oncology
  • Japan Association of Endocrine Surgery
  • The Japanese Society for Robotic Surgery
  • The Japan Laryngological Association
  • The Oto-Rhino-Laryngological Society of Japan, Inc.
  • Japan Society for Head and Neck Cancer: JSHNC
  • Japan Sosiety for Head And Neck Surgery
  • The Japan Broncho-esophagological Society
  • The Society of Practical Otolaryngology
  • Japan Society of Stomato-pharyngology

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  5. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Otorhinolaryngology,Head and Neck Surgery
  6. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery
  7. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Otorhinolaryngology,Head and Neck Surgery

Research Activities

Academic Papers

  1. Neoadjuvant and adjuvant pembrolizumab plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): Phase 3 KEYNOTE-689 study, CANCER RESEARCH, 85(8), 2025
  2. Prospective study for the identification of nivolumab biomarkers via analyses of pre-treatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT), CANCER RESEARCH, 84(6), 1195, 20240515
  3. COMPARISON OF OUTCOMES BETWEEN ENDOSCOIC SUBMUCOSAL DISSECTION AND ENDOSCOPIC LARYNGO-PHARYNGEAL SURGERY FOR SUPERFICIAL LARYNGO-PHARYNGEAL CANCER, GASTROINTESTINAL ENDOSCOPY, 99(6), AB328-AB329, 202406
  4. The Nasal Septal Swell Body May Have a Regulatory Role in Nasal Airway Passage That Depends on the Degree of Septal Deviation, J.Otorhinolaryngol. Hear. Balance Med., 6(1), 5-5, 2025
  5. Impact of hearing impairment in unilateral hearing loss: A multicenter study of standardized sound localization tests in Japan, AURIS NASUS LARYNX, 52(6), 690-703, 202512
  6. ★, Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer, NEW ENGLAND JOURNAL OF MEDICINE, 393(1), 37-50, 20250701
  7. Association between geriatric 8 (G8) scores and self-care decline in elderly patients with head and neck squamous cell carcinoma undergoing radiotherapy, SUPPORTIVE CARE IN CANCER, 33(10), 20250916
  8. The Nasal Septal Swell Body May Have a Regulatory Role in Nasal Airway Passage That Depends on the Degree of Septal Deviation, J.Otorhinolaryngol. Hear. Balance Med., 2025
  9. a, Cureus., 37(1), 108-112, 202501
  10. Minimally Invasive Cutting and Suture Technique for the Management of Caudal Septal Deviation., Cureus., 202501
  11. Comparison of Transoral Robotic Surgery and Endoscopic Laryngopharyngeal Surgery for Hypopharyngeal and Supraglottic Laryngeal Cancers, DEN OPEN, 6(1), 20250730
  12. Transoral Videolaryngoscopic Surgery for an Undifferentiated Pleomorphic Sarcoma of the Tongue Base: A Case Report, REPORTS, 8(2), 20250428
  13. Treatment outcomes and failure patterns in postoperative radiotherapy for major salivary gland carcinoma, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 55(7), 751-757, 202507
  14. A Case of Chromophobe Renal Cell Carcinoma Metastasizing to the Cervical Lymph Nodes after Long-term Follow-up, ACTA MEDICA OKAYAMA, 79(3), 213-219, 202506
  15. Seven cases of total laryngo-glossectomy combined with mandibulectomy: A retrospective case series from a single institution, AURIS NASUS LARYNX, 52(4), 327-335, 202508
  16. ★, Evaluation of real-time pharmacokinetics using fluorescence imaging system in Near-infrared photoimmunotherapy for head and neck cancer, AURIS NASUS LARYNX, 52(4), 346-353, 202508
  17. Efficacy of Vascular Ligation for the Prevention of Intra- and Postoperative Bleeding in Transoral Robotic Surgery for Oropharyngeal Cancer, CANCERS, 17(9), 20250425
  18. ★, Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiation therapy for locally advanced maxillary sinus cancer (JCOG1212): final analysis, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 30(3), 489-496, 202503
  19. Nationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasma exosome mRNAs from head and neck cancer patients (BIONEXT study), FRONTIERS IN IMMUNOLOGY, 15, 20250110
  20. Intelligibility Sound Therapy Enhances the Ability of Speech-in-Noise Perception and Pre-Perceptual Neurophysiological Response, BIOLOGY-BASEL, 13(12), 202412
  21. Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression, IMMUNO, 4(3), 247-265, 202409
  22. First-line pembrolizumab with or without chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up of the Japanese population of KEYNOTE-048, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2024 9
  23. Baseline eosinophil proportion is a useful predictor of immune-related adverse events following immune checkpoint inhibitor treatment for recurrent metastatic head and neck cancer, ACTA OTO-LARYNGOLOGICA, 144(9), 515-523, 20240901
  24. Incidence and risk factors associated with the development of hypothyroidism after postoperative chemoradiotherapy for head and neck cancer patients with high-risk features: Supplementary analysis of JCOG1008, ORAL ONCOLOGY, 157, 202410
  25. ★, Comparative analyses of short- and long-term outcomes between endoscopic submucosal dissection and endoscopic laryngo-pharyngeal surgery for superficial pharyngeal carcinomas, DEN OPEN, 5(1), 202504
  26. Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma, FRONTIERS IN IMMUNOLOGY, 15, 20240729
  27. ★, Dose-Finding and Efficacy Confirmation Trial of the Superselective Intra-arterial Infusion of Cisplatin and Concomitant Radiation Therapy for Locally Advanced Maxillary Sinus Cancer (JCOG1212): Results of the Efficacy Confirmation Phase in Patients with T4aN0M0, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 118(5), 1271-1281, 20240401
  28. Severe Type 2 Inflammation Leads to High Platelet-Activating-Factor-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps-A Hierarchical Cluster Analysis Using Bulk RNA Barcoding and Sequencing, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(4), 202402
  29. ★, Artificial intelligence-based diagnosis of the depth of laryngopharyngeal cancer, AURIS NASUS LARYNX, 51(2), 417-424, 202404
  30. ★, Transoral robotic surgery (TORS) in Japan: procedures, advantages and current status, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 54(3), 248-253, 20240309
  31. Extent of thyroidectomy and paratracheal lymph node dissection in total pharyngolaryngectomy for pyriform sinus cancer, and recurrence, survival, and postoperative hypoparathyroidism: A multicenter retrospective study, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 46(2), 269-281, 202402
  32. Oncostatin M's Involvement in the Pathogenesis of Chronic Rhinosinusitis: Focus on Type 1 and 2 Inflammation, BIOMEDICINES, 11(12), 202312
  33. Swallowing Exercise Evaluated Using High-Density Surface Electromyography in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial, MEDICINA-LITHUANIA, 59(12), 202312
  34. ★, Determining Invasion Depth in Superficial Pharyngeal Carcinoma by Transoral Ultrasonography, LARYNGOSCOPE, 133(9), 2192-2197, 202309
  35. Exhaled Nitric Oxide and Olfactory Dysfunction in Patients with Asthma: Association with Chronic Rhinosinusitis, MEDICINA-LITHUANIA, 59(10), 202310
  36. Head and neck cancer patients show poor oral health as compared to those with other types of cancer, BMC ORAL HEALTH, 23(1), 20230906
  37. Efficacy of Supportive Care for Radiodermatitis in Patients with Head and Neck Cancer: Supplementary Analysis of an Exploratory Phase II Trial, JOURNAL OF PERSONALIZED MEDICINE, 13(9), 202309
  38. An Evaluation of the Caudal End Deviation of the Nasal Septum Using the Quantitative Analysis of Computed Tomography, SURGICAL TECHNIQUES DEVELOPMENT, 12(3), 145-155, 202309
  39. ★, Examination of micro-superficial lesions of up to 5 mm in size in the pharyngolaryngeal region, JOURNAL OF LARYNGOLOGY AND OTOLOGY, 137(7), 749-756, 202307
  40. Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy, JOURNAL OF PERSONALIZED MEDICINE, 13(7), 202307
  41. Severe multiple simultaneous immune-related adverse events in a patient with head and neck cancer, AURIS NASUS LARYNX, 50(2), 309-313, 202304
  42. Functional Alteration and Differential Expression of the Bitter Taste Receptor T2R38 in Human Paranasal Sinus in Patients with Chronic Rhinosinusitis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(5), 202303
  43. Deep Association between Transglutaminase 1 and Tissue Eosinophil Infiltration Leading to Nasal Polyp Formation and/or Maintenance with Fibrin Polymerization in Chronic Rhinosinusitis with Nasal Polyps, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(21), 202211
  44. First-line pembrolizumab +/- chemotherapy for recurrent/metastatic head and neck cancer: Japanese subgroup of KEYNOTE-048, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(12), 1805-1817, 202212
  45. Effectiveness of Expanded Instantaneous Input Dynamic Range Adjustment on Speech Perception, JOURNAL OF PERSONALIZED MEDICINE, 12(11), 202211
  46. Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors, BMC CANCER, 22(1), 20221129
  47. ★, Swallowing function after transoral surgery for laryngopharyngeal cancer, PLoS One, 24(17), 20220624
  48. Impact of Preventive Measures on Subjective Symptoms and Antigen Sensitization against Japanese Cedar, Cypress Pollen and House Dust Mites in Patients with Allergic Rhinitis: A Retrospective Analysis in the COVID-19 Era, ATMOSPHERE, 13(7), 202207
  49. Swallowing function after transoral surgery for laryngopharyngeal cancer, PLoS One., 24(17), 202206
  50. Correction to: Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real‑world clinical practice: a multicentre retrospective clinical study, Int J Clin Oncol., 26((5)), 1005-1006, 20210410
  51. ★, Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma, SCIENTIFIC REPORTS, 12(1), 20220604
  52. Development of a radiomics and machine learning model for predicting occult cervical lymph node metastasis in patients with tongue cancer, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 134(1), 93-101, 202207
  53. Weekly Cisplatin Plus Radiation for Postoperative Head and Neck Cancer (JCOG1008): A Multicenter, Noninferiority, Phase II/III Randomized Controlled Trial, JOURNAL OF CLINICAL ONCOLOGY, 40(18), 1980-+, 20220620
  54. A long survival patient of anaplastic thyroid carcinoma treated with lenvatinib, AURIS NASUS LARYNX, 49(3), 515-519, 202006
  55. Distinct Gene Set Enrichment Profiles in Eosinophilic and Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Bulk RNA Barcoding and Sequencing, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(10), 202205
  56. A Case of Primary Osteosarcoma of the Mandible That Responded to Preoperative Chemotherapy: p16 as a Potential Prognostic Factor, ACTA MEDICA OKAYAMA, 76(2), 229-233, 202204
  57. Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis, AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 36(3), 313-322, 202205
  58. Sites of invasion of cancer of the external auditory canal predicting oncologic outcomes, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 43(10), 3097-3105, 202110
  59. Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitis, JOURNAL OF LARYNGOLOGY AND OTOLOGY, 135(9), 773-778, 202109
  60. Identification of a Novel Copy Number Variation of EYA4 Causing Autosomal Dominant Non-syndromic Hearing Loss, OTOLOGY & NEUROTOLOGY, 42(7), E866-E874, 202108
  61. The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 202107
  62. Baseline Neutrophil-to-Lymphocyte Ratio and Glasgow Prognostic Score are Associated with Clinical Outcome in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Treated with Nivolumab, ACTA MEDICA OKAYAMA, 75(3), 335-343, 202106
  63. Effectiveness of nivolumab affected by prior cetuximab use and neck dissection in Japanese patients with recurrent or metastatic head and neck cancer: results from a retrospective observational study in a real-world setting, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 26(6), 1049-1056, 202106
  64. Treatment outcomes of transoral robotic and non-robotic surgeries to treat oropharyngeal, hypopharyngeal, and supraglottic squamous cell carcinoma: A multi-center retrospective observational study in Japan, AURIS NASUS LARYNX, 48(3), 502-510, 202106
  65. Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real-world clinical practice: a multicenter retrospective clinical study, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 26(3), 494-506, 202103
  66. Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan, LARYNGOSCOPE, 131(3), E870-E874, 202103
  67. Long-term outcomes of induction chemotherapy followed by chemoradiotherapy using volumetric-modulated arc therapy as an organ preservation approach in patients with stage IVA-B oropharyngeal or hypopharyngeal cancers, JOURNAL OF RADIATION RESEARCH, 61(4), 554-562, 202007
  68. A Single Institution's Experience of Definitive Radiotherapy Using Volumetric-modulated Arc Therapy for Hypopharyngeal Cancers, ANTICANCER RESEARCH, 40(7), 4183-4190, 202007
  69. Extra-axial chordoma of the gingiva, AURIS NASUS LARYNX, 47(2), 299-304, 202004
  70. Baseline neutrophil-to-lymphocyte ratio (NLR) is associated with clinical outcome in recurrent or metastatic head and neck cancer patients treated with nivolumab, ACTA OTO-LARYNGOLOGICA, 140(2), 181-187, 20200201
  71. Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report, AURIS NASUS LARYNX, 46(5), 813-817, 201910
  72. Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis: A prospective study, AURIS NASUS LARYNX, 46(4), 507-512, 201908
  73. A Multicenter Phase II Trial of Docetaxel, Cisplatin, and Cetuximab (TPEx) Followed by Cetuximab and Concurrent Radiotherapy for Patients With Local Advanced Squamous Cell Carcinoma of the Head and Neck (CSPOR HN01: ECRIPS Study), FRONTIERS IN ONCOLOGY, 9, 201901
  74. Ganglioneuroma in The Neck Region: A Case Report., Hiroshima J. Med. Sci., 68((2,3)), 49-53, 2019
  75. Evaluation of Role of Prophylactic Swallowing Rehabilitation in Chemoradiotherapy for Advanced Head and Neck Cancer Using Novel Software Analysis of Videofluorography Images, Hiroshima J. Med. Sci., 68(2,3), 27-34, 2019
  76. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study., Lancet, 394, 1915-1928, 2019
  77. Extraskeletal osteosarcoma in the parotid gland: A case report, AURIS NASUS LARYNX, 45(3), 644-647, 2018
  78. ★, Low-dose dexamethasone with fosaprepitant and palonosetron to prevent cisplatin-induced nausea and vomiting in head and neck cancer patients, ACTA OTO-LARYNGOLOGICA, 138(10), 921-925, 2018
  79. Clinical outcomes of concurrent chemoradiotherapy with volumetric modulated arc therapy in patients with locally advanced nasopharyngeal carcinoma, JAPANESE JOURNAL OF RADIOLOGY, 35(11), 673-680, 201711
  80. Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study, BMC CANCER, 17, 20170505
  81. A clinical study of stage I and II squamous cell carcinoma of the tongue., Journal of Japan Society for Head and neck Surgery, 25(1), 21-27, 201506
  82. Lymph Node Metastasis in T4 Maxillary Sinus Squamous Cell Carcinoma: Incidence and Treatment Outcome, ANNALS OF SURGICAL ONCOLOGY, 21(5), 1706-1710, 201405
  83. Increased exhaled nitric oxide and its oxidation metabolism in eosinophilic chronic rhinosinusitis, AURIS NASUS LARYNX, 40(5), 458-464, 201310
  84. Reduced expression of p27 is correlated with progression in precancerous lesions of the larynx, AURIS NASUS LARYNX, 30(2), 163-168, 200305
  85. Outcomes of long-term nivolumab and subsequent chemotherapy in Japanese patients with head and neck cancer: 2-year follow-up from a multicenter real-world study, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 27(1), 95-104, 202201
  86. Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis, EUROPEAN JOURNAL OF INFLAMMATION, 20, 20220101
  87. Pneumococcal conjugate vaccines reduce myringotomy with tympanostomy tube insertion in young children in Japan, LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY, 7(1), 259-265, 202202

Invited Lecture, Oral Presentation, Poster Presentation

  1. Evaluation of Optimized Irradiation Strategies Using a Fluorescence Imaging System in Head and Neck Aluminox Therapy, Tsutomu Ueda, Takayuki Taruya, Nobuyuki Chikuie, Yuki Sato, Takayoshi Hattori, Takao Hamamoto, Sachio Takeno, ASHNO2025, 2025/11, Without Invitation, English
  2. Dose-finding and efficacy confirmation trial of the superselective intra-arterial cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (JCOG1212): Results of the efficacy confirmation phase in the T4b cohort, Akihiro Homma, Kazuto Matsuura, Rikiya Onimaru, Hiroyuki Tachibana, Tsutomu Ueda, Mitsuhiko Nakahira, Go Omura, Takahiro Asakage, Katsunori Katagiri, Akira Ohkoshi, Takashi Mukaigawa, Takashi Fuji, Yukinori Asada, Takeshi Beppu, Fumihiro Ito, Shintaro Iwamoto, Junki Mizusawa, Haruhiko Fukuda, Nobuhiko Hanai, Naomi Kiyota Head and Neck Cancer Study Group of Japan Clinical Oncology Group (JCOG-HNCSG), Japan, ESMO2025, 2025/10, Without Invitation, English
  3. Neoadjuvant-adjuvant pembrolizumab plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): randomized, open-label, phase 3 KEYNOTE-689 study, Ravindra Uppaluri, Robert I. Haddad, Yungan Tao, Christophe Le Tourneau, Nancy Y. Lee, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Irene Braña, Gustavo Vasconcelos Alves, Brett G. M. Hughes, Marc Oliva, Iane Pinto Figueiredo Lima, Tsutomu Ueda, Tomasz Rutkowski, Ursula Schroeder, Paul-Stefan Mauz, Thorsten Fuereder, Simon Laban, Nobuhiko Oridate, Aron Popovtzer, Nicolas Mach, Yevhen Korobko, Diogo Alpuim Costa, Anupama Hooda-Nehra, Cristina P. etc, CNO–Sociedade Portuguesa de Oncologia (CNO-SPO 2025), 2025/11, Without Invitation, other
  4. Neoadjuvant/adjuvant pembrolizumab plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): randomized, open-label, phase 3 KEYNOTE-689 study, Ravindra Uppaluri, Robert I. Haddad, Yungan Tao, Christophe Le Tourneau, Nancy Y. Lee, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Irene Braña, Gustavo Vasconcelos Alves, Brett G. M. Hughes, Marc Oliva, Iane Pinto Figueiredo Lima, Tsutomu Ueda, Tomasz Rutkowski, Ursula Schroeder, Paul-Stefan Mauz, Thorsten Fuereder, Simon Laban, Nobuhiko Oridate, Aron Popovtzer, Nicolas Mach, Yevhen Korobko, Diogo Alpuim Costa, Anupama Hooda-Nehra, Cristina P. etc, IAOO 2025, 2025/07, Without Invitation, English
  5. Neoadjuvant and Adjuvant Pembrolizumab (Pembro) Plus Standard of Care (SOC) for Resectable Locally Advanced Head and Neck Cancer (LA HNSCC) in the Asian Subgroup of the Phase 3 KEYNOTE-689 Trial, Makoto Tahara, Nobuhiko Oridate, Nobuhiro Hanai, Chih-Yen Chien, Yi-Chun Liu, Chia-Jui Yen, Muneyuki Masuda, Takashi Kinoshita, Ruey-Long Hong, Sadakatsu Ikeda, Ho Jung An, Ji-Won Kim, Minsu Kang, Kiyoaki Tsukahara, Sang Hee Cho, Yoshitaka Honma, Kenichi Takahashi, Sosuke Nakamura, Kimbery Benjamin, Tsutomu Ueda, ESMO ASIA 2025, 2025/12, Without Invitation, English
  6. Neoadjuvant and adjuvant pembrolizumab plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): phase 3 KEYNOTE-689 study, Ravindra Uppaluri, Robert I. Haddad , Yungan Tao, Christophe Le Tourneau , Nancy Y. Lee, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Irene Braña, Gustavo Vasconcelos Alves, Brett G. M. Hughes, Marc Oliva, Iane Pinto Figueiredo Lima, Tsutomu Ueda, Tomasz Rutkowski, Ursula Schroeder, Paul-Stefan Mauz, Thorsten Fuereder, Simon Laban, Nobuhiko Oridate, Aron Popovtzer, Nicolas Mach, Yevhen Korobko, Diogo Alpuim Costa, Anupama Hooda-Nehra, Cristina P. etc, KSMO2025, 2025/09, Without Invitation, English
  7. Neoadjuvant and Adjuvant Pembrolizumab (Pembro) Plus Standard of Care (SOC) in Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma (LA HNSCC): Postoperative Risk Subgroup Analysis of KEYNOTE-689, Nancy Y. Lee, Douglas Adkins, Robert I. Haddad, Yungan Tao, Christophe Le Tourneau, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Raquel Granado Carrasco, Gustavo Vasconcelos Alves, Brett G. M. Hughes, Marc Oliva, Iane P. F. Lima, Tsutomu Ueda, Cole Manschot, Kimberly Benjamin, Burak Gumuscu, Ravindra Uppaluri, ASTRO 2025, 2025/09, Without Invitation, English
  8. Neoadjuvant-adjuvant (neoadj-adj) pembrolizumab (pembro) plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): Participant-reported outcomes (PRO) in KEYNOTE-689, Yungan Tao, Douglas Adkins, Robert I. Haddad, Christophe Le Tourneau, Nancy Y. Lee, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Irene Braña, Gustavo Vasconcelos Alves, Brett G. M. Hughes, Marc Oliva, Iane P. F. Lima, Tsutomu Ueda, Kelly McQuarrie, Cole Manschot, Kimberly Benjamin, Ravindra Uppaluri, ESMO2025, 2025/10, Without Invitation, English
  9. Neoadjuvant and adjuvant pembrolizumab (pembro) plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): exploratory efficacy analyses of the phase 3 KEYNOTE-689 study, Douglas Adkins, Robert I. Haddad, Yungan Tao, Christophe Le Tourneau, Nancy Y. Lee, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Irene Braña, Gustavo Vasconcelos Alves, Brett G. M. Hughes, Marc Oliva, Iane Pinto Figueiredo Lima, Tsutomu Ueda, Cole Manschot, Kimberly Benjamin, Behzad Bidadi, Ravindra Uppaluri, ASCO2025, 2025/05, Without Invitation, English
  10. Exploration of therapeutic targets using growth inhibitors for Head and Neck mucosal melanoma, Takayoshi Hattori, Makiko Fujii, Tsutomu Ueda, Akira Ishikawa, Hiroaki Tahara, Yuki Sato, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Sachio Takeno, 2025/05, Without Invitation, English
  11. Neoadjuvant and adjuvant pembrolizumab plus standard of care (SOC) in resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC): Phase 3 KEYNOTE-689 study, Ravindra Uppaluri, Robert I. Haddad, Yungan Tao, Christophe Le Tourneau, Nancy Y. Lee, William Westra, Rebecca Chernock, Makoto Tahara, Kevin Harrington, Arkadiy L. Klochikhin, Irene Braña, Gustavo Vasconcelos Alves, Brett G.M. Hughes, Marc Oliva, Iane Pinto Figueiredo Lim, Tsutomu Ueda, Tomasz Rutkowski, Ursula Schroeder, Paul-Stefan Mauz, Thorsten Fuereder, Simon Laban, Nobuhiko Oridate, Aron Popovtzer, Nicolas Mach, Yevhen Korobko, Diogo Alpuim Costa, Anupama Hooda-Nehra, Cristina etc, AACR Annual Meeting 2025, 2025/04/27, Without Invitation, English
  12. Evaluation of real time pharmacokinetics using fluorescence imaging system in Alluminox treatment for head and neck cancer., Tsutomu Ueda, Takayuki Taruya, Nobuyuki Chikuie, Yuki Sato, Takayoshi Hattori, Takao Hamamoto, Sachio Takeno, 2024/10/26, Without Invitation, Japanese
  13. Endoscopic resection of posterior nasal nerves for severe allergic rhinitis in the COVID-19 era in Japan., S Takeno, K Takemoto, Y Okamoto, T Taruya, K Yumii, T Ueda, 2023/02, Without Invitation, English, UK Birmingham
  14. Artificial Intelligence-based diagnosis of the depth of laryngopharyngeal cancer, Kouhei Yumii, Tsutomu Ueda, Daishuke Kawahara, Nobuyuki Chikuie,Takayuki Taruya, Takashi Kono,Takao Hamamoto,Takashi Ishino, Sachio Takeno, BACO International 2023, 2023/02, Without Invitation, English, UK Birmingham
  15. Photoimmunotherapy for recurrent head and neck cancer, short-term effect in 3 cases at our hospital., T Taruya, T Ueda, K Yumii, N Chikuie, T Hamamoto, S Takeno, BACO International 2023, 2023/02, Without Invitation, English, Birmingham, UK
  16. Experience sharing.NANORAY312 P3 Japan Country Call, Ueda T, NANORAY312 P3 Japan Country Call Investigator Meeting, 2023/12, With Invitation, English, WEB
  17. Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for maxillary sinus cancer (JCOG 1212): Results of the T4a cohort., Ueda T, Matsuura K, Onimaru R, Yoshida D, Shinomiya H, Ohkoshi A, Hayashi R, Saito Y, Tachibana H, Yoshimoto S, Fujii T, Nakahira M, Iwae S, Ito F, Homma A, AOS 2023, 2023/10, Without Invitation, English, Yokohama
  18. First-Line Pembrolizumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: 5-Year Update of the Japanese Subgroup of KEYNOTE‑048, Shimizu Y, Takahashi S, Oridate N, Tanaka K, Fujimoto Y, Matsumoto K, Tomoya Yokota T, Yamazaki T, Takahashi M, Ueda T, Hanai N Yamaguchi H, Hara H, Yoshizaki T, Yasumatsu R, Nakayama M, Shiga K, Fujii T, Mitsugi K, Takahashi K, Nohata N, Gumuscu B, Lerman N, Makoto Tahara M., JSCO2023, 2023/10, Without Invitation, English, Yokohanma
  19. Investigation into the diagnosis of invasion depth in superficial pharyngeal carcinomas by ultrasonography., T Ueda, Y Urabe, M Fukuhara, K Yumii, N Chikuie, T Taruya, T Kono, T Hamamoto, M Hattori, M Takumida, T Ishino, and S Takeno, BACO International 2023, 2023/02, Without Invitation, English
  20. A clinical study of transoral surgery for laryngo-pharyngeal lesions., K Yumii, T Ueda, N Chikuie, T Taruya, T Kono, T Hamamoto, T Ishino, and S Takeno, Asian-pacific Congress of Laparoscopic Surgery(ACRLS), 2022/12, Without Invitation, English
  21. Determining invasion depth in superficial pharyngeal carcinoma by ultrasonography, Tsutomu Ueda, Yuji Urabe, Motomitsu Fukuhara, Kouhei Yumii, Nobuyuki Chikuie, Takayuki Taruya, Takashi Kono, Takao Hamamoto, Minoru Hattori, Masaya Takumida, Takashi Ishino, and Sachio Takeno , BACO International 2023, 2023/02/15, Without Invitation, English
  22. Tumor immune characterization identifies age-stratified biomarkers for nivolumab in patients with head and neck squamous cell carcinoma: A nationwide collaborative study in Japan., T Tsujikawa; K Ohno; S Saburi; J Mitsuda; K Yoshimura; A Kimura; H Morimoto; G Ohmura; A Arai; H Ogi; S Shibata; Y Ariizumi; A Tasaki; R Takahashi; Y Tateishi; H Kawabe; S Ikeda; K Morita; T Tsunoda; T Akashi; M Kurata; I Imoto; Y Shimizu; A Watanabe; Y Asada; R Hayashi; Y Saito; H Ozawa; K Tsukahara; N Oridate; A Horii; T Maruo; N Hanai; H Inohara; H Iwai; T Fujii; K Nibu; S Iwae; T Ueda; R Yasumatsu; H Umeno; M Masuda; K Itoh; S Hirano; T Asakage., AACR ANNUAL MEETING 2022, 2022/04/08, Without Invitation, English
  23. Dose-finding and efficacy confirmation trial of the superselective intra-arterial infusion of cisplatin and concomitant radiotherapy for locally advanced maxillary sinus cancer (JCOG1212): Results of the efficacy confirmation phase in the T4a cohort., Akihiro Homma, Kazuto Matsuura, Rikiya Onimaru, Daisuke Yoshida, Hirotaka Shinomiya, Akira Ohkoshi, Ryuichi Hayashi, Yuki Saito, Hiroyuki Tachibana, Kiyoto Shiga, Tsutomu Ueda, Yukinori Asada, Hirokazu Uemura, Akira Seto, Takeshi Beppu, Kazuki Ishikawa, Masashi Mikami, Kenichi Nakamura, Haruhiko Fukuda, Naomi Kiyota, Head and Neck Cancer Study Group of Japan Clinical Oncology Group (JCOG-HNCSG), ASCO, 2022/06, Without Invitation, English
  24. Japanese Subgroup Analysis of Phase 3 KEYNOTE-048: First-Line Pembrolizumab for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, 2019/07/18, Without Invitation, English
  25. A MULTICENTER PHASE II STUDY OF REBAMIPIDE LIQUID FOR CHEMORADIOTHERAPY-INDUCED ORAL MUCOSITIS IN HEAD AND NECK CANCER PATIENTS, Takenori Ogawa, Tomoya Yokota, Takashi Fujii, Shinya Ueda, Shigemichi Iwae, Kaoru Tanaka, Ichiro Ota, Kazuto Matsuura, Yasushi Fujimoto, Takeshi Beppu, Yasuhisa Hasegawa, Shunji Takahashi, Nobuya Monden, Kenji Okami, Hiromi Kojima, Tsutomu Ueda, Keita Sasaki, Shigeru Hirano, Masato Fujii, Makoto Tahara, 2017 MASCC/ISOO Annual Meeting, 2017/06/22, Without Invitation, English
  26. A Multicenter Phase2 Trial of Docetaxel,Cisplatin and Cetuximab (TPE) Followed by Cetuximab with Concurrrent Radiotherapy in patients with Local Advanced Squamous Cell Carcinoma of the Head and Neck (ECRIPS study), Sadamoto Zenda, Yosuke Ota, Naomi Kiyota, Susumu Okano, Masato Fujii, Morimasa Kitamura, Shunji Takahashi, Tsutomu Ueda, Nobuya Monden, Takeharu Yamanaka, and Makoto Tahara, 2017 ASCO Annual Meeting, 2017/06/02, Without Invitation, English
  27. Examination Concerning Dosage of Dexamethasone for Nausea and Vomiting. 4th Congress of Asian Society of Head and Neck Oncology, Tsutomu Ueda, Hiromi Furuie, Ichiro Sugimoto, Takashi kono, Takayuki Taruya, Takao Hamamoto, Katsuhiro Hirakawa, 4th Congress of Asian Society of Head and Neck Oncology, 2015/06/04, Without Invitation, English
  28. Results of Induction Chemotherapy + VMAT for Stage IVA/B Oropharyngeal and Hypopharyngeal Cancer., Yuji Murakami, Nobuki Imano, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Tsutomu Ueda, Katsuhiro Hirakawa, Yasushi Nagata, 4th Congress of Asian Society of Head and Neck Oncology, 2015/06/04, Without Invitation, English
  29. Short-term Outcomes for Nasopharyngeal Carcinoma Treated by Volumetric Modulated Arc Therapy., Nobuki Imano, Yuji Murakami, Hiromi Sakaguchi, Katsuma Kubo Hideo Kawabata, Yoshiko Doi, Tomoyuki Okabe, Masahiro Kenjo, Tomoki Kimura, Tsutomu Ueda, Katsuhiro Hirakawa, Yasushi Nagata, 4th Congress of Asian Society of Head and Neck Oncology, 2015/06/04, Without Invitation, Japanese
  30. Clinical Study of Parotid Cancer, 4th Congress of Asian Society of Head and Neck Oncology, 2015/06/04, Without Invitation, English
  31. Artificial Intelligence-based diagnosis of the depth of laryngopharyngeal cancer., K Yumii, T Ueda, D Kawahara, N Chikuie, T Taruya, T Kono, T Hamamoto, T Ishino, and S Takeno, BACO International 2023, 2023/02/15, Without Invitation, English
  32. Photoimmunotherapy for recurrent head and neck cancer, short-term effect in 3 cases at our hospital., T Taruya, T Ueda, T Hamamoto, T Kono, N Chikuie, K Yumii, T Ishino and S Takeno, BACO International 2023, 2023/02/15, Without Invitation, English
  33. Transoral Videolaryngoscopic Surgery for a giant undifferentiated pleomorphic sarcoma of the tongue base., T Taruya, T Ueda, T Hamamoto, T Kono, N Chikuie, K Yumii, T Ishino and S Takeno, Asian-pacific Congress of Laparoscopic Surgery(ACRLS), 2022/12, Without Invitation, English

Awards

  1. Best Doctors in Japan
  2. 2020, Best Doctors in Japan, Best Doctors in Japan
  3. 2021, Best Doctors in Japan, Best Doctors in Japan
  4. 2022, Best Doctors in Japan, Best Doctors in Japan

External Funds

Acceptance Results of Competitive Funds

  1. Practical Research for Innovative Cancer Control, 2023//4//1, 2024//3//3
  2. Practical Research for Innovative Cancer Control, 2023//4//1, 2024//3//3
  3. 2023/12/01, 2025/03/31
  4. Practical Research for Innovative Cancer Control, 2022//0/4/, 2023//0/3/
  5. Practical Research for Innovative Cancer Control, 2021/04/01, 2022/03/31
  6. Practical Research for Innovative Cancer Control, 2021/04/01, 2022/03/31
  7. Practical Research for Innovative Cancer Control , 2019/04/01, 2020/03/31
  8. Practical Research for Innovative Cancer Control, 2020/04/01, 2021/03/31
  9. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2020, 2022
  10. Practical Research for Innovative Cancer Control, 2023/04/01, 2024/03/31
  11. Practical Research for Innovative Cancer Control, 2022/04/01, 2023/03/31
  12. Practical Research for Innovative Cancer Control, 2023/04/01, 2024/03/31

Social Activities

Organizing Academic Conferences, etc.

  1. 2024/02, 2024/02
  2. 2022/07, 2022/07
  3. 2020/11, 2020/11
  4. 2018/07

History as Peer Reviews of Academic Papers

  1. 2023, Auris Nasus Larynx, Others
  2. 2017, Auris Nasus Larynx, Others
  3. 2018, Auris Nasus Larynx
  4. 2019, Auris Nasus Larynx
  5. 2020, Auris Nasus Larynx
  6. 2021, Auris Nasus Larynx
  7. 2022, Auris Nasus Larynx