TAKAFUMI MITUHARA

Last Updated :2025/06/16

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Assistant Professor
E-mail
mitsuharahiroshima-u.ac.jp
Self-introduction
Neurological Surgeon, specialized in skull base tumors, spine surgery, neurovascular surgery, and Neurological regenerative medicine

Basic Information

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Neurosurgery

Research Keywords

  • Neurosurgery, Neurological Surgeon, Brain tumor, Neurovascular disease, Spine, Neurological Regenerative Medicine

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Intensive, Symptomatology, Diagnosis and Treatment
  2. 2025, Undergraduate Education, Year, Medical Neuroscience III
  3. 2025, Undergraduate Education, Intensive, Practice for medical research
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2025, Undergraduate Education, Intensive, Practice of Medicine II

Research Activities

Academic Papers

  1. Clinical Characteristics and Management Considerations of Craniocervical Junction Arteriovenous Fistulas With Subarachnoid Hemorrhage: A Multicenter Study., Neurosurgery, 20250414
  2. Optimization of image shoot timing for cerebral veins 3D-digital subtraction angiography by interventional angiography systems, RADIOLOGICAL PHYSICS AND TECHNOLOGY, 18(1), 36-46, 202503
    Link to Paper Search Results by DOI
  3. High frequency exercise after human cranial bone-derived mesenchymal stem cells transplantation enhances motor functional recovery following traumatic brain injury in mice, BRAIN RESEARCH, 1853, 20250415
    Link to Paper Search Results by DOI
  4. Repeated human cranial bone-derived mesenchymal stem cell transplantation improved electrophysiological recovery in a spinal cord injury rat model, NEUROSCIENCE LETTERS, 844, 20250101
    Link to Paper Search Results by DOI
  5. Cases of cervical extramedullary recurrent malignant solitary fibrous tumors treated multimodally with pazopanib hydrochloride, Spinal Surgery, 38(2), 147-148, 202408
  6. Lower Cervical Dural Arteriovenous Fistula with a "Skip Lesion" in the Brainstem: A Case Report, NMC Case Rep J, 11(0), 175-179, 20240613
  7. Optimal treatment strategy for low-grade spinal cord astrocytoma: a retrospective, multicenter analysis by the Neurospinal Society of Japan, JOURNAL OF NEUROSURGERY-SPINE, 41(6), 699-707, 202412
    Link to Paper Search Results by DOI
  8. Human cranial bone-derived mesenchymal stem cells cultured under simulated microgravity can improve cerebral infarction in rats, EXPERIMENTAL NEUROLOGY, 382, 202412
    Link to Paper Search Results by DOI
  9. Relevance of the Foramen of Vesalius for Preoperative Tumor Embolization in Skull Base Meningioma, WORLD NEUROSURGERY, 187, E501-E508, 202407
    Link to Paper Search Results by DOI
  10. Characteristics of MicroRNA Expression Depending on the Presence or Absence of Meningioma in Patients with Neurofibromatosis Type 2: A Secondary Analysis, NEUROLOGIA MEDICO-CHIRURGICA, 64(3), 116-122, 202403
    Link to Paper Search Results by DOI
  11. Shorter survival time of adolescents and young adult patients than older adults with spinal cord glioblastoma: a multicenter study, JOURNAL OF NEUROSURGERY-SPINE, 40(2), 196-205, 202402
    Link to Paper Search Results by DOI
  12. Cell Therapy for Ischemic Stroke : Status and Prospects, 32(12), 808-813, 202312
  13. Orbital fibrous capsule formation with abscess found 3 years after penetrating injury from a wooden chopstick, Orbit, 1-6, 20231030
    Repository URL
  14. Surgical and Endovascular Treatments for Asymptomatic Arteriovenous Fistulas at the Craniocervical Junction: A Multicenter Study, WORLD NEUROSURGERY, 175, E1049-E1058, 202307
    Link to Paper Search Results by DOI
  15. Impact of intravenously administered cranial bone-derived mesenchymal stem cells on functional recovery in experimental spinal cord injury, NEUROSCIENCE LETTERS, 799, 137103, 20230316
    Link to Paper Search Results by DOI
  16. A novel rat model for longitudinal electrophysiological evaluation after cold-induced brain injury, JOURNAL OF NEUROSURGERY, 139(3), 840-847, 202309
    Link to Paper Search Results by DOI
  17. The Impact of Adjuvant Radiotherapy on Clinical Performance Status in Patients With Grade II Spinal Cord Astrocytoma - A Nationwide Analysis by the Neurospinal Society of Japan, NEUROSPINE, 20(3), 766-773, 202309
    Link to Paper Search Results by DOI
  18. Clinical Characteristics and Long- term Outcomes of Spinal Pilocytic Astrocytomas: A Multicenter Retrospective Study by the Neurospinal Society of Japan, NEUROSPINE, 20(3), 774-782, 202309
    Link to Paper Search Results by DOI
  19. Assessment of Intraoperative Spinal Angiography via the Popliteal Artery for Spinal Vascular Diseases, WORLD NEUROSURGERY, 169, 1-8, 202301
    Link to Paper Search Results by DOI
  20. Congestive myelopathy due to craniocervical junction arteriovenous fistulas mimicking transverse myelitis: a multicenter study on 27 cases, J Neurol, 270(3), 1745-1753, 20221220
  21. Establishment of longitudinal transcranial stimulation motor evoked potentials monitoring of the forelimbs and hindlimbs in an ischemic stroke rat model, SCIENTIFIC REPORTS, 12(1), 20422, 20221128
    Link to Paper Search Results by DOI
  22. Longitudinal electrophysiological changes after mesenchymal stem cell transplantation in a spinal cord injury rat model, PLoS One, 17(8), e0272526, 20220806
  23. Current Trends in the Surgical Management of Intramedullary Tumors: A Multicenter Study of 1,033 Patients by the Neurospinal Society of Japan, Neurospine, 19(2), 441-452, 20220707
  24. Ischemic complications in the neurosurgical and endovascular treatments of craniocervical junction arteriovenous fistulas: a multicenter study, J Neurosurg, 1-10, 20220511
  25. Healing process of Type II odontoid fractures after C1-C2 posterior screw fixation: Predictive factors for pseudoarthrosis, Surg Neurol Int, 13, 116, 20220506
  26. Intramuscular Coherence of the Lower Flexor Muscles during Robotic Ankle-Assisted Gait, JOURNAL OF MOTOR BEHAVIOR, 54(3), 344-353, 20220504
    Link to Paper Search Results by DOI
  27. Distinctive MicroRNA Profiles in Serum of Patients with Neurofibromatosis Type 2: A Bioinformatic Exploratory Study, World Neurosurg, 164, e127-e133, 20220419
  28. Natural history of acute unruptured vertebral basilar artery dissection: Temporal changes in imaging findings and contributory factors, CLINICAL NEUROLOGY AND NEUROSURGERY, 222, 107450, 202211
    Link to Paper Search Results by DOI
  29. Neurosurgical versus endovascular treatment of craniocervical junction arteriovenous fistulas: a multicenter cohort study of 97 patients, JOURNAL OF NEUROSURGERY, 137(8), 373-380, 202208
    Link to Paper Search Results by DOI
  30. Imaging evolution from "presyrinx" to syrinx in patient with spinal lipoma, Surg Neurol Int, 12, 633, 20220331
  31. ★, Transplantation of rat cranial bone-derived mesenchymal stem cells promotes functional recovery in rats with spinal cord injury, SCIENTIFIC REPORTS, 11(1), 21907, 20211109
    Link to Paper Search Results by DOI
  32. Comparisons of Neurotrophic Effects of Mesenchymal Stem Cells Derived from Different Tissues on Chronic Spinal Cord Injury Rats, Stem Cells Dev, 30(17), 865-875, 20210622
  33. A novel bone-thinning technique for transcranial stimulation motor-evoked potentials in rats, Sci Rep, 11(1), 12496, 20210616
    Repository URL
  34. Spinal arteriovenous fistula in the lipoma of the filum terminale: A report of two cases and literature review, Surg Neurol Int, 12, 103, 20210422
    Repository URL
  35. Rationale and Design of BeatNF2 Trial: A Clinical Trial to Assess the Efficacy and Safety of Bevacizumab in Patients with Neurofibromatosis Type 2 Related Vestibular Schwannoma, CURRENT ONCOLOGY, 28(1), 726-739, 20210213
    Link to Paper Search Results by DOIRepository URL
  36. Integration of Neuro-regenerative Medicine and Robot Rehabilitation, Japanese Journal of Neurosurgery, 30, 128-136, 20210201
    Repository URL
  37. Effects of Preservation of the Semispinalis Cervicis Inserted into C2 on Craniocervical Alignment After Laminoplasty, WORLD NEUROSURGERY, 146, E1367-E1376, 20201215
    Link to Paper Search Results by DOIRepository URL
  38. Neurosurgical versus endovascular treatment of spinal dural arteriovenous fistulas: a multicenter study of 195 patients, JOURNAL OF NEUROSURGERY-SPINE, 34(3), 514-521, 20201114
    Link to Paper Search Results by DOI
  39. Extensive solitary fibrous tumor centered on the temporal bone: A case report, Otolaryngology Case Reports, 17, 100239, 20201023
  40. ★, Neuroregenerative therapy with cranial bone-derived mesenchymal stem cells, Precisoin Medicine, 3(8), 777-782, 20200815
  41. Microsurgical versus endovascular treatment of spinal epidural arteriovenous fistulas with intradural venous drainage: a multicenter study of 81 patients, J Neurosurg Spine, 1-11, 20200425
    Repository URL
  42. Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats, NEUROLOGIA MEDICO-CHIRURGICA, 60(2), 83-93, 20200121
    Link to Paper Search Results by DOI
  43. Transient Cerebral Vasospasm After Carotid Artery Stenting: A Case Report and Literature Review, WORLD NEUROSURGERY, 135, 107-111, 20191215
    Link to Paper Search Results by DOI
  44. ★, Asymptomatic spinal dural arteriovenous fistula: case series and systematic review, J Neurosurg Spine, 1-9, 20190720
  45. Cauda Equina Occupation Ratio as a New Imaging Parameter for the Evaluation of Spinal Dural Arteriovenous Fistulae, WORLD NEUROSURGERY, 130, E1020-E1027, 20190716
    Link to Paper Search Results by DOI
  46. ★, Neuroregenerative ability of cranial bone-derived mesenchymal stem cells, BIO Clinica, 8(1), 114-119, 20190610
  47. Localized controlled fibrin glue application with gelatin sponge for hemostasis and dural defect repair: Technical note., Interdisciplinary Neurosurgery-Advanced Techniques and Case Management, 18, 100476, 20190318
  48. Japanese Surveillance of Neuroendovascular Therapy in JR-NET - Part II. Japanese Registry of NeuroEndovascular Treatment 3. Main Report, NEUROLOGIA MEDICO-CHIRURGICA, 59(3), 106-115, 20190308
    Link to Paper Search Results by DOI
  49. A Case of One Staged Cerebral Revascularization for Hemodynamic Insufficiency in Anterior and Middle Cerebral Artery Area Caused by Internal Carotid Artery Occlusion, Surgery for Cerebral Stroke, 47(4), 272-276, 20180501
    Link to Paper Search Results by DOI
  50. Concurrent Schwannoma and Meningioma Arising in the Same Spinal Level: A Report of Two Cases, NMC Case Rep J, 5(4), 105-109, 20181018
  51. Usefulness of Preoperative Simulation in Skull Base Approach: A Case Report, JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 79, S378-S382, 20180914
    Link to Paper Search Results by DOI
  52. Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report, NEUROSPINE, 15(3), 277-282, 20180827
    Link to Paper Search Results by DOI
  53. Factors Related to Frailty Associated with Clinical Deterioration After Meningioma Surgery in the Elderly, WORLD NEUROSURGERY, 119, E167-E173, 20180722
    Link to Paper Search Results by DOI
  54. Hyperperfusion after revascularization for quasimoyamoya disease associated with Graves' disease: case report, Neurological Surgery, 46(6), 501-508, 20180601
  55. Rat Cranial Bone-Derived Mesenchymal Stem Cell Transplantation Promotes Functional Recovery in Ischemic Stroke Model Rats, STEM CELLS AND DEVELOPMENT, 27(15), 1053-1061, 20180523
    Link to Paper Search Results by DOI
  56. Multivariate risk factor analysis and literature review of postoperative deterioration in Karnofsky Performance Scale score in elderly patients with skull base meningioma, NEUROSURGICAL FOCUS, 44(4), E14, 20180403
    Link to Paper Search Results by DOI
  57. Intraoperative Neurophysiologic Monitoring for Degenerative Cervical Myelopathy, NEUROSURGERY CLINICS OF NORTH AMERICA, 29(1), 159-167, 20171128
    Link to Paper Search Results by DOI
  58. Epidemiology and Overview of the Clinical Spectrum of Degenerative Cervical Myelopathy, NEUROSURGERY CLINICS OF NORTH AMERICA, 29(1), 1-12, 20171128
    Link to Paper Search Results by DOI
  59. ★, Ruptured dissecting aneurysms of the A1 segment of the anterior cerebral artery: three case reports and a review of the literature, Neurosurgical review, 41(2), 409-414, 20170311
  60. Pure Intra-optic Canal Schwannoma: Report of Two Cases, Asian J Neurosurg, 12(4), 797-800, 20171109
  61. A Case of Intradural Retroclival Chordoma, No Shinkei Geka, 45(7), 623-627, 20170720
  62. The Position and Role of Four-Dimensional Computed Tomography Angiography in the Diagnosis and Treatment of Spinal Arteriovenous Fistulas, WORLD NEUROSURGERY, 103, 611-619, 20170404
    Link to Paper Search Results by DOI
  63. Three Cases of Moyamoya Disease with a History of Kawasaki Disease, No Shinkei Geka, 43(11), 1005-1010, 20151110
  64. ★, The characteristics of human cranial bone marrow mesenchymal stem cells, Neurosci Lett, 606, 161-166, 20150908
  65. Ginkgo leaf sign: a highly predictive imaging feature of spinal meningioma, J Neurosurg Spine, 23(5), 642-646, 20150801
  66. Visualization of regional cerebrospinal fluid flow with a dye injection technique in focal arachnoid pathologies, J Neurosurg Spine, 22(5), 554-557, 20150214
  67. Unstable moyamoya disease: clinical features and impact on perioperative ischemic complications, J Neurosurg, 122(2), 400-407, 20141126
  68. Gowers' intrasyringeal hemorrhage associated with Chiari type I malformation in Noonan syndrome, Surg Neurol Int, 5, 6, 20140228
  69. ★, Simulated microgravity facilitates cell migration and neuroprotection after bone marrow stromal cell transplantation in spinal cord injury, Stem Cell Res Ther, 4(2), 35, 20130404
  70. A Case of a Primary Radiation-Induced Malignant Peripheral Nerve Sheath Tumor in the Cauda Equina in a Patient with Neurofibromatosis Type 2, Journal of Spine, 2(1), 20121228
  71. Application of 4D-CTA using 320-row area detector computed tomography on spinal arteriovenous fistulae: initial experience, Neurosurg Rev, 36(2), 289-296, 20121201
  72. Feasibility and Limitations of the Retrosigmoid and Presigmoid Approaches Combined With the Anterior Petrosal Approach to Meningiomas in the Petroclival Area, Neurosurgery Quarterly, 23(1), 7-12, 201302
  73. Endovascular coil embolization for ruptured kissing aneurysms associated with A1 fenestration, Surg Neurol Int, 2, 85, 20110713
  74. Lateral buttock congenital dermal sinus tract, Neurol Med Chir (Tokyo), 51(6), 460-462, 20110628
  75. PRIMITIVE NEUROECTODERMAL TUMOR OF THE FRONTAL LOBE IN CHILDHOOD: A CASE REPORT, Neuro-Oncology, 12(6), 1162-1162, 20100601
  76. Giant serpentine aneurysm arising from the middle cerebral artery successfully treated with trapping and anastomosis: case report, Neurol Med Chir (Tokyo), 49(2), 77-80, 20090228
  77. Endovascular treatment for dural arteriovenous fistula of the anterior condylar confluence involving the anterior condylar vein. A report of two cases, Interv Neuroradiol, 14(3), 313-317, 20080930

Invited Lecture, Oral Presentation, Poster Presentation

  1. Histological and clinical consideration of the refluxed medullary veins in thoracolumbar spinal dural arteriovenous fistulas, Takafumi Mitsuhara, Hitoshi Yamahata, Kiyoharu Shimizu, Masaaki Takeda, Kaoru Kurisu, and Satoshi Yamaguchi, The 10th ASIA SPINE, 2019/09/21, Without Invitation, English, Seoul, Korea
  2. THE NEUROPROTECTIVE AND NEUROREGENERATIVE POTENTIAL OF HUMAN CRANIAL BONE MARROW-DERIVED MESENCHYMAL STEM CELLS, Takafumi Mitsuhara, Takeshi Imura, Takashi Ohtsuka, Junpei Ohshita, Masaru Abiko, Kaori Iwamoto, Takahito Okazaki, Yumi Kawahara, Louis Yuge, Kaoru Kurisu, ISSCR 2018, 2018/06/21, Without Invitation, English, International society for stem cell research, Melbourne Convention and Exhibition Centre, Australia