TAKASHI HANDA

Last Updated :2025/06/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Associate Professor
Web Site
https://researchmap.jp/h-a-n-d-a/?lang=japanese
https://orcid.org/0000-0003-3956-8077
E-mail
handanbhiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2025/04/01, Graduate School of Biomedical and Health Sciences(Medicine), Hiroshima University, Department of Neurobiology, Associate professor
  • 2020/04/01, 2025/03/31, Graduate School of Biomedical and Health Sciences(Medicine), Hiroshima University, Department of Neurobiology, Assistant professor
  • 2014/04/01, 2020/03/31, research center caesar (Germany), Department of Behavior and Brain Organization, postdoc
  • 2012/04/01, 2014/03/31, RIKEN Brain Science Institute, Neural Circuit Theory, Researcher
  • 2009/02/01, 2012/03/31, RIKEN, Computational Science Research Program, Project reseacher

Educational Backgrounds

  • Kyoto University, Japan, 2005/04, 2009/01
  • Nihon Fukushi University, Japan, 2003/04, 2005/03
  • Kwansei Gakuin University, Japan, 1999/04, 2003/03

Academic Degrees

  • M.S., Nihon Fukushi University
  • Ph.D., Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;General physiology
  • Complex systems;Brain sciences;Brain biometrics

Research Keywords

  • Neurophysiology, Neuroanatomy, Systems neuroscience

Affiliated Academic Societies

  • The Japan Neuroscience Society
    Related URL
  • The Japanese Association of Anatomists
  • The Physiological Society of Japan
  • The Japanese Society for Animal Psychology
  • Society for Neuroscience
    Related URL

Educational Activity

Course in Charge

  1. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Neurobiology
  2. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Neurobiology
  3. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Neurobiology
  4. 2025, Undergraduate Education, Intensive, Medical Neuroscience II
  5. 2025, Undergraduate Education, First Semester, Structure of human body II
  6. 2025, Graduate Education (Master's Program) , First Semester, Seminar
  7. 2025, Graduate Education (Master's Program) , Second Semester, Seminar
  8. 2025, Graduate Education (Master's Program) , First Semester, Research
  9. 2025, Graduate Education (Master's Program) , Second Semester, Research
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  11. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  12. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  13. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  14. 2025, Graduate Education (Doctoral Program) , 3Term, Understanding disorders in neural systems
  15. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Neurobiology

Research Activities

Academic Papers

  1. ★, Cell type-specific contribution to the initiation of cortical spreading depolarization in the mouse, Biochemical and Biophysical Research Communications, 20250131
    Link to Paper Search Results by DOI
  2. ★, Single-trial representations of decision-related variables by decomposed frontal corticostriatal ensemble activity, eNeuro, 11(8), ENEURO.0172-24.2024, 20240725
    Link to Paper Search Results by DOI
  3. ★, Cholinergic modulation of interhemispheric inhibition in the mouse motor cortex, Cerebral Cortex, 20240723
  4. Neural circuitry activity correlated to the behavioral traits of individuals, The CELL, 55(8), 37-40, 20230620
  5. Synergistic information in the frontal cortex-striatal pathway, bioRxiv, 20210101
    Link to Paper Search Results by DOI
  6. ★, Concomitant processing of choice and outcome in frontal corticostriatal ensembles correlates with performance of rats, Cerebral Cortex, 31(9), 4357-4375, 2021
  7. ★, Neuronal stability in medial frontal cortex sets individual variability in decision-making, Nature Neuroscience, 21, 1764-1773, 2018
  8. ★, Neuronal correlates of motion-defined shape perception in primate dorsal and ventral streams, European Journal of Neuroscience, 48, 3171-3185, 2018
  9. Accurate action potential inference from a calcium sensor protein through biophysical modeling, bioRxiv, 20181129
    Link to Paper Search Results by DOI
  10. ★, Medial frontal circuit dynamics represents probabilistic choices for unfamiliar sensory experience, Cerebral Cortex, 27(7), 3818-3831, 2017
  11. Temporal property of single-cell activity in response to motion-defined shapes in monkey dorsal and ventral cortical areas, Neuroreport, 28(13), 793-799, 2017
  12. Modulation of neuronal activity with cue-invariant shape discrimination in the primate superior temporal sulcus, Neuroscience, 268, 221-235, 2014
  13. Reward-modulated motor information in identified striatum neurons, The Journal of Neuroscience, 33(25), 10209-10220, 2013
  14. Neuronal activity during discrimination of shapes defined by motion in area V4, Neuroreport, 21, 532-536, 2010
  15. Differential activity to shapes under shape-from-motion condition in macaque middle temporal area, Neuroscience, 156, 1118-1135, 2008

Invited Lecture, Oral Presentation, Poster Presentation

  1. Neuromodulation of acetylcholine on interhemispheric interaction in the mouse cerebral motor cortex, Takashi Handa, Qing Zhang, Hidenori Aizawa, The 145th annual meeting of the pharmaceutical society of Japan, 2025/03/28, Without Invitation, English, The pharmaceutical society of Japan, Fukuoka
  2. Cholinergic neuromodulation of interhemispheric inhibition in the mouse motor cortex, Takashi Handa, Qing Zhang, Hidenori Aizawa, APPW2025, 2025/03/19, Without Invitation, English, the Japanese Association of Anatomists, the Physiological Society of Japan, the Japanese Pharmacological Society, Chiba
  3. Reduced glutamate transporter activity induces the spontaneous spreading depolarization in larval zebrafish brain, Qing Zhang, Takashi Handa, Hidenori Aizawa, APPW2025, 2025/03/19, Without Invitation, English, the Japanese Association of Anatomists, the Physiological Society of Japan, the Japanese Pharmacological Society, Chiba
  4. Neuromodulation of acetylcholine on interhemispheric interaction in the mouse cerebrum, Takashi Handa, Qing Zhang, Hidenori Aizawa, Stroke2025, 2025/03/06, Without Invitation, Japanese, The Japan Stroke Society, Japanese Society of Surgery for Cerebral Stroke, Osaka
  5. Cholinergic neuromodulation of interhemispheric inhibition in the mouse motor cortex, Takashi Handa, Qing Zhang, Hidenori Aizawa, The 47th annual meeting of molecular biology society of Japan, 2024/11/27, Without Invitation, Japanese, Molecular biology society of Japan, Fukuoka
  6. Dynamic single-trial representation of decision-related information by decomposed frontal cortico-striatal ensemble activity across trials, Takashi Handa, The 84th Annual Meeting of the Japanese Society for Animal Psychology, 2024/10/27, Without Invitation, Japanese, the Japanese Society for Animal Psychology, Inuyama
  7. Neural circuit mechanisms underlying neuromodulation on interhemispheric inhibition by acetylcholine, Takashi Handa, 2024/10/03, With Invitation, Japanese, okyo University of Agriculture and Technology, Koganei city
  8. Single-trial representation of behavioral task related information by decomposed ensemble activity in rat frontal cortico-striatal circuit, Takashi Handa, The 46th annual meeting of the Japanese Society of Comparative Physiology and Biochemistry, 2024/09/30, Without Invitation, English, the Japanese Society of Comparative Physiology and Biochemistry, Nagoya
  9. Cholinergic modulation of interhemispheric inhibition in the mouse motor cortex, Takashi Handa, Qing Zhang, Hidenori Aizawa, Neuro2024, 2024/07/25, Without Invitation, English, Fukuoka
  10. Behavioral task related information encoded in frontal cortico-striatal ensembles while a task progresses, Takashi Handa, Tomoki Kurikawa, The 101st Annual Meeting of The Physiological Society of Japan, 2024/03/28, Without Invitation, English, The Physiological Society of Japan, Kitakyushu
  11. Analysis of corticostriatal circuitory activity with tensor decomposition, Takashi Handa, 2023/10/29, Without Invitation, Japanese, Kawasaki Medical School, Kurashiki
  12. Cholinergic modulation fo interhemispheric interaction in the mouse motor cortex, Takashi Handa, Qing Zhang, Hidenori Aizawa, The 2nd International Symposium HYPER-ADAPTABILITY, 2023/10/28, Without Invitation, English, Kyoto
  13. Cholinergic modulation of interhemispheric interaction in the mouse motor cortex, Takashi Handa, Hidenori Aizawa, The 46th Annual Meeting of the Japan Neuroscience Society, 2023/08/02, Without Invitation, English, The Japan Neuroscience Society, Sendai
  14. Pharmacological effect on characteristics of field potential and spike activity evoked by optogenetic callosal excitation in mouse secondary motor cortex, Takashi Handa, Hidenori Aizawa, Neuro2022, 2022/06/30, Without Invitation, English, Japan Neuroscience Society, Japanese Society for Neurochemistry, Japanese Neural Network Society, Okinawa
  15. Concomitant encoding of outcome-based decision making in frontal corticostriatal ensembles, Handa Takashi, Harukuni Rie, Fukai Tomoki, The 43rd annual meeting of the Japan Neuroscience Society, 2020/07/29, Without Invitation, English
  16. Different neural landscape regulates individual differences in sensoryguided decision making, Kurikawa Tomoki, Handa Takashi, and Fukai Tomoki, Cosyne, 2018, Without Invitation, English, Denvor CO, USA
  17. Neural ensemble dynamics in rat dorsomedial prefrontal cortex during probabilistic sensory-cued choice, Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki, Bernstein conference, 2013, Without Invitation, English, Tuebingen, Germany
  18. Neural ensemble dynamics in rat dorsomedial prefrontal cortex during a sensory-guided choice task, Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki., Neuro 2013, 2013, Without Invitation, English, Kyoto, Japan
  19. Representation of sensory feature and spatial choice in dorsomedial prefrontal cortex of rat making action decision using sensory information, Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki., Society for Neuroscience, 2012, Without Invitation, English, New Orleans, U.S.A
  20. Cell type-specific activity in rodent prefrontal cortex for making action decision using novel information., Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki, The 8th Federation of European Neuroscience Society Forum, 2012, Without Invitation, English, Barcelona, Spain
  21. Ensemble activity of putative pyramidal neuron and interneuron in the medial prefrontal cortex of rats making action decision, Handa Takashi, Takekawa Takashi, Harukuni Rie, Isomura Yoshikazu, and Fukai Tomoki, Japanese Neuroscience Meeting, 2011, Without Invitation, English, Yokohama, Japan
  22. Neuronal activity of the extrastriate area V4 during shape discrimination in the shape-from-motion condition., Handa Takashi, Inoue Masato, and Mikami Akichika., Society for Neuroscience, 2006, Without Invitation, English, Atlanta, U.S.A.
  23. Neuronal activities of the area MT and MST during the shape and direction discrimination in the shape from motion condition., Handa Takashi, Katai Satoshi, Kuno Reiko, Unno Shumpei, Inoue Masato, and Mikami Akichika, Society for Neuroscience, 2005, Without Invitation, English, Washington, DC, U.S.A.

External Funds

Acceptance Results of Competitive Funds

  1. 2025, 2027
  2. Grant-in-Aid for Scientific Research (C), 2022, 2025
  3. 2020, 2022
  4. 2020, 2023
  5. 2012, 2014

Social Activities

History as Peer Reviews of Academic Papers

  1. 2020, European Journal of Neuroscience, reviewer, 1
  2. 2023, iScience, reviewer, 1