Kozue Hamao

Last Updated :2021/07/19

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
E-mail
kozuehiroshima-u.ac.jp
Self-introduction
I am studying the regulatory mechanism of cytoskeleton. In particular, I am focusing on the regulation of microtubule stability by dynamin-2.

Basic Information

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Research Fields

  • Biology;Biological Science;Functional biochemistry

Research Keywords

  • cytokinesis
  • microtubules
  • dynamin
  • myosin II
  • contractile ring

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  2. 2021, Undergraduate Education, Second Semester, English Seminar on Biological Science
  3. 2021, Undergraduate Education, 2Term, Advanced Biology
  4. 2021, Undergraduate Education, 2Term, Cell Biology A
  5. 2021, Undergraduate Education, Second Semester, Seminar for Cell Biology
  6. 2021, Undergraduate Education, First Semester, Special Study for Graduation
  7. 2021, Undergraduate Education, Second Semester, Special Study for Graduation
  8. 2021, Undergraduate Education, First Semester, Practice for Fundamental Biology I
  9. 2021, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  10. 2021, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  11. 2021, Graduate Education (Master's Program) , First Semester, Seminar for Biological Science (Lecture)
  12. 2021, Graduate Education (Master's Program) , Second Semester, Seminar for Biological Science (Lecture)
  13. 2021, Graduate Education (Master's Program) , First Semester, Seminar for cell biology
  14. 2021, Graduate Education (Master's Program) , Second Semester, Seminar for cell biology
  15. 2021, Graduate Education (Doctoral Program) , Second Semester, Career Development for Life Science
  16. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Basic Biology A
  17. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Basic Biology A
  18. 2021, Graduate Education (Master's Program) , 2Term, Seminar for Advanced Research in Basic Biology A
  19. 2021, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology B
  20. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Basic Biology B
  21. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Basic Biology B
  22. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  23. 2021, Graduate Education (Master's Program) , 2Term, Molecular Physiology
  24. 2021, Graduate Education (Master's Program) , 2Term, Seminar for Advanced Research in Basic Biology C
  25. 2021, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology D
  26. 2021, Graduate Education (Doctoral Program) , 2Term, Seminar for Advanced Research in Basic Biology E
  27. 2021, Graduate Education (Doctoral Program) , 3Term, Seminar for Advanced Research in Basic Biology F
  28. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  29. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  30. 2021, Graduate Education (Master's Program) , 1Term, Advanced Technologies for Life Science
  31. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Biomedical Science A
  32. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Biomedical Science A
  33. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Biomedical Science B
  34. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Biomedical Science B
  35. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  36. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  37. 2021, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  38. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  39. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. ★, Impairment of cytokinesis by cancer-associated DAPK3 mutations, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 533(4), 1095-1101, 20201217
  2. ★, ZIP kinase phosphorylated and activated by Rho kinase/ROCK contributes to cytokinesis in mammalian cultured cells, EXPERIMENTAL CELL RESEARCH, 386(1), 20200101
  3. Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow, SCIENTIFIC REPORTS, 9, 20190904
  4. ★, Characterization of myosin II regulatory light chain isoforms in HeLa cells, CYTOSKELETON, 72(12), 609-620, 201512
  5. ★, Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 459(4), 686-691, 20150417
  6. Aurora B but Not Rho/MLCK Signaling Is Required for Localization of Diphosphorylated Myosin II Regulatory Light Chain to the Midzone in Cytokinesis, PLOS ONE, 8(8), 20130807
  7. Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during cytokinesis., Biochemical and biophysical research communications, 417(2), 20120113
  8. Phosphorylation of myosin II regulatory light chain controls its accumulation, not that of actin, at the contractile ring in HeLa cells., Experimental cell research, 318(8), 915-924, 2012
  9. Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells, BIOCHEMICAL JOURNAL, 435, 569-576, 20110501
  10. ★, Proline-rich domain in dynamin-2 has a low microtubule-binding activity: how is this activity controlled during mitosis in HeLa cells?, JOURNAL OF BIOCHEMISTRY, 148(5), 533-538, 201011
  11. Direct evidence for roles of phosphorylated regulatory light chain of myosin II in furrow ingression during cytokinesis in HeLa cells, GENES TO CELLS, 14(5), 555-568, 200905
  12. ★, New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells, EXPERIMENTAL CELL RESEARCH, 315(7), 1336-1345, 20090415
  13. Dvl regulates endo- and exocytotic processes through binding to synaptotagmin, GENES TO CELLS, 12, 49-61, 20070112
  14. Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 456(2), 224-231, 20061215
  15. The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-A, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 301(4), 886-890, 2003
  16. Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge, BIOCHEMICAL JOURNAL, 370, 551-556, 2003
  17. Spatial localization of mono- and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cells, CELL STRUCTURE AND FUNCTION, 27(6), 479-486, 2002
  18. Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells, ONCOGENE, 21(38), 5852-5860, 2002
  19. Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo, BIOCHEMICAL JOURNAL, 367, 335-345, 2002
  20. Phosphorylation at threonine-18 in addition to phosphorylation at serine-19 on myosin-II regulatory light chain is a mitosis-specific event, CYTOMETRY, 47(3), 150-157, 2002
  21. HeLa ZIP kinase induces diphosphorylation of myosin II regulatory light chain and reorganization of actin filaments in nonmuscle cells, ONCOGENE, 20(57), 8175-8183, 2001
  22. Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblasts, FEBS LETTERS, 509(3), 365-369, 2001
  23. Activation of actin-activated MgATPase activity of myosin II by phosphorylation with MAPK-activated protein kinase-1b (RSK-2), JOURNAL OF BIOCHEMISTRY, 128(3), 435-440, 2000