TAKAFUMI OGAWA

Last Updated :2025/06/04

Affiliations, Positions
Hiroshima University, Assistant Professor
E-mail
takafumi-ogawahiroshima-u.ac.jp
Self-introduction
Using yeast S. cerevisiae and nematode C. elegans, I study the functions regulated by nutrient signaling, such as cell growth, metabolism, and stress resistance, as well as the mechanisms by which nutrient responsiveness declines with aging, aiming to gain insights into the significance of nutrient sensing mechanism in the process of aging.

Basic Information

Major Professional Backgrounds

  • 2018/04/01, 2023/03/31, Hiroshima University, Research Fellow
  • 2018/04/01, 2023/03/31, Harvard Medical School, Research Fellow
  • 2016/04/01, 2018/03/31, Hiroshima University, Graduate School of Advanced Sciences of Matter, JSPS Research Fellow (DC2)
  • 2020/04/01, 2022/09/30, Harvard Medical School, Joslin Diabetes Center, JSPS Overseas Research Fellow
  • 2023/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor

Academic Degrees

  • Hiroshima University
  • Hiroshima University

Research Fields

  • Agricultural sciences;Agricultural chemistry;Applied biochemistry
  • Agricultural sciences;Agricultural chemistry;Applied microbiology
  • Biology;Biological Science;Cell biology
  • Biology;Biological Science;Molecular biology

Research Keywords

  • Lifespan
  • Aging
  • Nutrient sensing
  • Metabolism
  • Growth
  • Nematode
  • Yeast

Affiliated Academic Societies

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • The Molecular Biology Society of Japan
  • Genetics Society of America

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Second Semester, Basic Experiments in Chemistry
  2. 2025, Undergraduate Education, Second Semester, Experiments on Biotechnology II
  3. 2025, Undergraduate Education, Year, Graduation Thesis

Research Activities

Academic Papers

  1. Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast., The Journal of Biological Chemistry, 288(15), 10558-10566, 2013
  2. Evidence of antagonistic regulation of restart from G(1) delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast., Bioscience, Biotechnology, and Biochemistry, 77(10), 2002-2007, 2013
  3. Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains., Journal of Bioscience and Bioengineering, 123(1), 8-14, 2017
  4. ★, Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK., Proceedings of the National Academy of Sciences of the United States of America, 113(42), 11913-11918, 2016
  5. ★, S-adenosyl-L-homocysteine extends lifespan through methionine restriction effects., Aging Cell, 21(5), e13604, 2022
  6. Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics., Proceedings of the National Academy of Sciences of the United States of America, 120(2), e2204750120, 2023
  7. ★, Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing., Molecular Cell, 84(23), 4558-4575.e8, 2024

Awards

  1. 2024/11/04, The 9th International Symposium on Biomedical Engineering Young Researchers Presentation Award, The Research Center for Biomedical Engineering

External Funds

Acceptance Results of Competitive Funds

  1. 2024/04/01, 2026/03/31
  2. 2023/12/01, 2025/09/30
  3. 2024/04/01, 2025/03/31
  4. 2025/04/01, 2026/03/31