HIROTSUGU MIYOSHI

Last Updated :2025/07/07

Affiliations, Positions
Division of Surgical Services, Associate Professor/Lecturer
E-mail
h-miyoshihiroshima-u.ac.jp

Basic Information

Educational Backgrounds

  • Ehime University, Japan, 2000/04, 2006/03

Academic Degrees

  • Hiroshima University

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Systemic Disease Control
  2. 2025, Undergraduate Education, Intensive, Introduction to clinical clerkship
  3. 2025, Undergraduate Education, Intensive, Practice for medical research
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  5. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Anesthesiology and Critical Care
  6. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Anesthesiology and Critical Care
  7. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Anesthesiology and Critical Care
  8. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Anesthesiology and Critical Care

Research Activities

Academic Papers

  1. Comparison between single bolus dose administration and continuous infusion of remimazolam for general anesthesia induction in non-cardiac surgery: a single-center prospective randomized controlled trial, BMC ANESTHESIOLOGY, 25(1), 20250402
    Link to Paper Search Results by DOI
  2. Impact of Operating Table Height on the Difficulty of Mask Ventilation and Laryngoscopic View, JOURNAL OF CLINICAL MEDICINE, 13(19), 202410
    Link to Paper Search Results by DOI
  3. Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Diabetes-Induced Neuropathic Pain, JOURNAL OF CLINICAL MEDICINE, 13(14), 202407
    Link to Paper Search Results by DOI
  4. Impact of proficiency in the transcatheter aortic valve implantation procedure on clinical outcomes: a single center retrospective study, BMC ANESTHESIOLOGY, 24(1), 20240621
    Link to Paper Search Results by DOI
  5. Prevention of Oxygen Desaturation in a Patient With Previous Experience of Severe Hypoxia in Modified Electroconvulsive Therapy by Transnasal Humidified Rapid-Insufflation Ventilator Exchange: A Case Report, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(5), 20240518
    Link to Paper Search Results by DOI
  6. Remimazolam-based total intravenous anesthesia in a patient with a confirmed diagnosis of malignant hyperthermia: a case report, JA CLINICAL REPORTS, 10(1), 20240422
    Link to Paper Search Results by DOI
  7. Reply to Su et al. Comment on "Matsumoto et al. Remimazolam's Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial. J. Clin. Med. 2023, 12, 5402", JOURNAL OF CLINICAL MEDICINE, 13(4), 202402
    Link to Paper Search Results by DOI
  8. Rapid Dantrolene Administration with Body Temperature Monitoring Is Associated with Decreased Mortality in Japanese Malignant Hyperthermia Events, BIOMED RESEARCH INTERNATIONAL, 2023, 20230222
    Link to Paper Search Results by DOI
  9. Functional characterization of RYR1 variants identified in malignant hyperthermia susceptible individuals, NEUROMUSCULAR DISORDERS, 33(12), 951-963, 202312
    Link to Paper Search Results by DOI
  10. Delayed Nonimmune Anaphylaxis Caused by Ropivacaine for Preoperative Nerve Blocks: A Case Report, A & A PRACTICE, 17(11), 202311
    Link to Paper Search Results by DOI
  11. Delayed Nonimmune Anaphylaxis Caused by Ropivacaine for Preoperative Nerve Blocks: A Case Report, A & A PRACTICE, 17(11), 202311
    Link to Paper Search Results by DOI
  12. Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants, GENES, 14(11), 202311
    Link to Paper Search Results by DOI
  13. Remimazolam's Effects on Postoperative Nausea and Vomiting Are Similar to Those of Propofol after Laparoscopic Gynecological Surgery: A Randomized Controlled Trial, JOURNAL OF CLINICAL MEDICINE, 12(16), 202308
    Link to Paper Search Results by DOI
  14. Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report, AMERICAN JOURNAL OF CASE REPORTS, 24, 20230321
    Link to Paper Search Results by DOI
  15. Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center, BIOMED RESEARCH INTERNATIONAL, 2022, 20221022
    Link to Paper Search Results by DOI
  16. Effects of high-dose opioid analgesia on survival, pain relief, quality of life and adverse drug reactions in cancer and neuropathic pain patients: a retrospective cohort study in real-world clinical practice, ANNALS OF TRANSLATIONAL MEDICINE, 10(18), 202209
    Link to Paper Search Results by DOI
  17. Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report, JA CLINICAL REPORTS, 8(1), 20221005
    Link to Paper Search Results by DOI
  18. Postoperative Tracheal Compression Requiring Transposition of the Brachiocephalic Artery After Bentall Surgery Combined With Total Arch Replacement in a Patient With Loeys-Dietz Syndrome, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 36(8), 2532-2535, 202208
    Link to Paper Search Results by DOI
  19. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135(1), 128-135, 202207
    Link to Paper Search Results by DOI
  20. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50(4), 312-319, 202207
    Link to Paper Search Results by DOI
  21. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report, JA CLINICAL REPORTS, 8(1), 20220609
    Link to Paper Search Results by DOI
  22. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein, JA CLINICAL REPORTS, 8(1), 20220412
    Link to Paper Search Results by DOI
  23. Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic, PLOS ONE, 17(2), 2022
    Link to Paper Search Results by DOI
  24. ★, Several ryanodine receptor type 1 gene mutations of p.Arg2508 have the potential to cause malignant hyperthermia., Anesthesia & Analgesia, 121(4), 994-1000, 2015
  25. Incidence and laryngoscopic grade of adult patients with Mallampati class zero airway., Minerva Anestesiologica, 82(3), 372-373, 2016
  26. Shoulder pain after hepatectomy occurs more frequently on the right side. A retrospective observational analysis., European Journal of Anaesthesiology, 32(10), 744-745, 2015
  27. A case of nephrogenic diabetes insipidus during transsphenoidal pituitary adenomectomy, J Neurosurg Anesthesiol, 2015
  28. Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome, PEDIATRICS INTERNATIONAL, 59(1), 97-98, 201701
    Link to Paper Search Results by DOI
  29. Paravertebral block catheter breakage by electrocautery during thoracic surgery, JOURNAL OF ANESTHESIA, 31(3), 463-466, 201706
    Link to Paper Search Results by DOI
  30. Genetic and functional analysis of the RYR1 mutation p.Thr84Met revealed a susceptibility to malignant hyperthermia, JOURNAL OF ANESTHESIA, 32(2), 174-181, 201804
    Link to Paper Search Results by DOI
  31. Myotoxicity of local anesthetics is equivalent in individuals with and without predisposition to malignant hyperthermia, JOURNAL OF ANESTHESIA, 32(4), 616-623, 201808
    Link to Paper Search Results by DOI
  32. Rotational thromboelastometry-guided perioperative management of coagulation in a patient with Heyde's syndrome undergoing transcatheter aortic valve implantation, JA CLINICAL REPORTS, 5, 20190111
    Link to Paper Search Results by DOI
  33. Postoperative thoracic and low back pain following endovascular aortic repair associated with stenting location, JOURNAL OF ANESTHESIA, 33(1), 75-79, 201902
    Link to Paper Search Results by DOI
  34. A case of coronary artery spasm caused by manipulation of the neck: heart rate variability analysis, Journal of Anesthesia, 26(6), 905-909, 2012
  35. Asystole following skull clamp to Chiari malformation, Journal of Anesthesia, 29(2), 317-317, 2015
  36. Evaluation of hemodynamics during posture change to knee-chest position by FloTrac™., 55(1), 75-77, 20190301
  37. Precise prediction of right atrium position within expiratory phase thorax., 55(1), 79-82, 20190301
  38. Relationship Between Age and Frequency of Side Effects Associated with Postoperative Analgesia, 55(1), 67-70, 20190301
  39. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245, 20200315
    Link to Paper Search Results by DOI
  40. Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients, JOURNAL OF MEDICAL INVESTIGATION, 67(1-2), 139-144, 202002
  41. Functional analysis of newly identifiedRYR1variants in patients susceptible to malignant hyperthermia, JOURNAL OF ANESTHESIA, 34(5), 658-665, 202010
    Link to Paper Search Results by DOI
  42. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70(5), 508-519, 2020
    Link to Paper Search Results by DOI
  43. Intraoperative responses of motor evoked potentials to the novel intravenous anesthetic remimazolam during spine surgery: a report of two cases, JA CLINICAL REPORTS, 6(1), 20201209
    Link to Paper Search Results by DOI
  44. Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation, BIOMED RESEARCH INTERNATIONAL, 2021, 20210104
    Link to Paper Search Results by DOI
  45. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35(2), 168-174, 202104
    Link to Paper Search Results by DOI
  46. Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report, JOURNAL OF ANESTHESIA, 35(2), 311-314, 202104
    Link to Paper Search Results by DOI
  47. Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy, SCIENTIFIC REPORTS, 11(1), 20210304
    Link to Paper Search Results by DOI
  48. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11(1), 20210505
    Link to Paper Search Results by DOI
  49. Acute-onset paraplegia as an unexpected complication under general anesthesia in supine position during abdominal endovascular aneurysm repair: a case report, JA CLINICAL REPORTS, 7(1), 20210602
    Link to Paper Search Results by DOI
  50. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(5), 5119-5127, 202105
    Link to Paper Search Results by DOI
  51. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, Nutrition, Metabolism and Cardiovascular Diseases, 2021
  52. Factors related to accidental dural puncture in epidural anesthesia patients, Journal of Clinical Anesthesia, 2015
  53. Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31(10), 2979-2986, 20210922
    Link to Paper Search Results by DOI
  54. Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters, ANESTHESIA AND ANALGESIA, 133(5), 1107-1115, 202111
    Link to Paper Search Results by DOI
  55. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(10), 10160-10169, 202110
    Link to Paper Search Results by DOI
  56. Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, DIABETOLOGY & METABOLIC SYNDROME, 13(1), 20211120
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Current status of muscle contraction testing and functional analysis of malignant hyperthermia-related gene variants in East Asia, Hirotsugu Miyoshi, Yuko Noda, Sophia Tsong Huey Chew, Wei Keang Tan, Sidharta Manggala, Lian Kah Ti, Pei-Lung Chen, Huei-Ming Yeh, Jen-Hao Liu, Asian Malignant Hyperthermia Alliance (AMHA), 18th World Congress of Anaesthesiologists, 2024/03, Without Invitation, English
  2. Asian Malignant Hyperthermia Alliance (AMHA) Pursing Precise and Comprehensive Treatment Contracture Tests: When, Who, and How it is done in Japan, Hirotsugu Miyoshi, 18th World Congress of Anaesthesiologists, 2024/03, With Invitation, English
  3. Genetic panel testing of malignant hyperthermia patients in Japan, Ayako Sumii, Hirotsugu Miyoshi, Keiko Mukaida, Tsuyoshi Ikeda, Kenshiro Kido, Yuko Noda, Toshimichi Yasuda, Sachiko Otsuki, Rieko Kanzaki, Yasuo Tsutsumi, 18th World Congress of Anaesthesiologists, 2024/03, Without Invitation, English
  4. Evaluation of exposure history to volatile inhalation anesthetics in patients with malignant hyperthermia, Ayako Sumii, Hirotsugu Miyoshi, Keiko Mukaida, Tsuyoshi Ikeda, Kenshiro Kido, Yuko Noda, Toshimichi Yasuda, Sachiko Otsuki, Rieko Kanzaki, Yasuo Tsutsumi, 18th World Congress of Anaesthesiologists, 2024/03, Without Invitation, English
  5. Effect of high concentration of sevoflurane on the development of malignant hyperthermia and rhabdomyolysis in a mouse model, Kenshiro Kido, Tsuyoshi Ikeda, Hirotsugu Miyoshi, Ayako Sumii, Keiko Mukaida and Yasuo, Euroanaesthesia 2024, 2024/05, Without Invitation, English
  6. Protein Kinase C (PKC) domains involved in propofol-induced PKC translocation, Narasaki S, Sakai N, Miyoshi H, Ishii T, Tsutsumi YM, Asian and Australasian Congress of Anaesthesiologists 2022, Without Invitation, Japanese
  7. Effect of Remimazolam on intracellular calcium regulation of cultured skeletal muscle in patients with predisposision to malignant hyperthermia, Watanabe T, Miyoshi H, Mukaida K, Kido K, Otsuki S, Yasuda T, Tsutsumi YM, Asian and Australasian Congress of Anaesthesiologists 2022, 2022/11/10, Without Invitation, English
  8. Functional analysis of RYR1 variants identified in IVCT positive individuals, Yuko Noda, Hirotsugu Miyoshi, Thierry Girard, Susan, 40th Annual Meeting of the EMHG, 2022/05/25, Without Invitation, English
  9. Analysis of respiratory sound monitoring on the non-ventilated side during one-lung ventilation, Hirotsugu Miyoshi, Nakamura R, Haraki T, Saeki N, Tsutsumi Y. M, Shime N., EUROANAESTHESIA 2020, 2020/05/30, Without Invitation, English
  10. Opioidsensitivity index estimated by vascular stiffness is highly correlated with blood pressure, Ryuji Nakamura, Kamiya S, Saeki N, Miyoshi H, Tsutsumi Y, Tsuji T., EUROANAESTHESIA 2020, 2020/05/30, Without Invitation, English
  11. Opioid sensitivity estimated by vascular stiffness predicts blood pressure after a skin incision, Kamiya S, Nakamura R, Saeki N, Miyoshi H, Tsutsumi Y, Tsuji T, EUROANAESTHESIA 2020, 2020/05/30, Without Invitation, English
  12. Functional Analysis of Newly Found Ryanodine Receptor 1 Variants in Malignant Hyperthermia, Yuko Noda, Toshimichi Yasuda, Hirotsugu Miyoshi, Keiko Mukaida, Hiroshi Hamada, American Society of Anesthesiologists 2019, 2019/11/19, Without Invitation, English
  13. Position of epidural catheter and postoperative analgesia for pancreatic surgery, Hirotsugu Miyoshi, Ryuji Nakamura, Toshimichi Yasuda, Hiroshi Hamada,Takahiro Kato, Shima Taguchi, Kyoko Oshita, Masashi Kawamoto, The 15th Asian and Oceanic Society of Regional Anesthesia and Pain Medicine Congress, 2019/04/18, Without Invitation, English
  14. Relationship between the intervertebral level and pain score in epidural analgesia after gastrectomy, Ryuji Nakamura, Hirotsugu Miyoshi, Toshimichi Yasuda, Hiroshi Hamada,Takahiro Kato, Shima Taguchi, Kyoko Oshita, Masashi Kawamoto, The 15th Asian and Oceanic Society of Regional Anesthesia and Pain Medicine Congress, 2019/04/18, Without Invitation, English
  15. Validation of A Novel, Fluid Status Monitoring Device, Using A Non-invasive Blood Pressure Measurement Cuff, Ryuji Nakamura, Haruka Morimoto, Satoshi Kamiya, Noboru Saeki, Hirotsugu Miyoshi, Hiroshi Hamada, Masashi Kawamoto, American Sosiety of Anesthesiologist 2018, 2018/10/13, Without Invitation, English
  16. Relation between the loaded pressure and the flow rate of various infusion lines in high pressurized condition., Hirotsugu Miyoshi, Ryuji Nakamura, Hiroshi Hamada, Masashi Kawamoto, American Sosiety of Anesthesiologist 2018, 2018/10/13, Without Invitation, English
  17. Evolution of malignant hyperthermia in Japan, Sachiko Otsuki, Keiko Mukaida, Hirotsugu Miyoshi, Toshimichi Yasuda, Hiroshi Hamada, Masashi Kawamoto, Euroanaesthesia2018, 2018/06/02, Without Invitation, Japanese
  18. Precise prediction of right atrium position during expiratory phase of thorax., Hirotsugu Miyoshi, Ryuji Nakamura, Toshimichi Yasuda, Hiroshi Hamada, Masashi Kawamoto, World Congless of Anesthesiologist 2016, 2016/08/28, Without Invitation, English, published
  19. A novel algorithm of Ezavp as central venous pressure determined with conventional noninvasive blood pressure cuff, Ryuji Nakamura, Noboru Saeki, Haruka Morimoto, Teiji Ukawa, Hirotsugu Miyoshi, Masashi Kawamoto, WCA2016, 2016, Without Invitation, English, published

Patented

  1. Patent, 6308829, 2018/03/23

External Funds

Acceptance Results of Competitive Funds

  1. 2024, 2026
  2. 2023
  3. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2022, 2023
  4. 2019