Hideo Shigeishi

Last Updated :2026/07/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor
E-mail
shigehiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2006/05, Graduate School of Biomedical Sciences, Hiroshima University, Assistant Professor
  • 2007/04, Graduate School of Biomedical Sciences, Hiroshima University, assistant professor
  • 2011/06, 2012/06, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, researcher

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Research Fields

  • Biology;Biological Science;Molecular biology
  • Medicine,dentistry, and pharmacy;Dentistry;Surgical dentistry
  • Medicine,dentistry, and pharmacy;Society medicine;Hygiene and public health

Research Keywords

  • Cancer stem cell
  • human papilloma virus
  • perioperative oral health care
  • Occupational Oral Health
  • community dwelling elderly

Educational Activity

Course in Charge

  1. 2026, Liberal Arts Education Program1, 4Term, General Health and Oral Sciences II
  2. 2026, Undergraduate Education, 4Term, Overview of Dentistry
  3. 2026, Undergraduate Education, 2Term, Public Health Administration
  4. 2026, Undergraduate Education, 3Term, Environmental and Public Health
  5. 2026, Undergraduate Education, 1Term, Oral Health
  6. 2026, Undergraduate Education, 3Term, Examination and Diagnosis
  7. 2026, Undergraduate Education, 3Term, Practice of General Health and Dental Health I
  8. 2026, Undergraduate Education, 4Term, Practice of General Health and Dental Health II
  9. 2026, Undergraduate Education, 4Term, Social Welfare
  10. 2026, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  11. 2026, Undergraduate Education, 4Term, Introduction to Dental Science
  12. 2026, Undergraduate Education, 1Term, Oral Health
  13. 2026, Undergraduate Education, 2Term, Public Health Administration
  14. 2026, Undergraduate Education, 4Term, Practicum of Oral Health
  15. 2026, Undergraduate Education, 3Term, Environmental and Public Health
  16. 2026, Undergraduate Education, 1Term, Oral Surgery and Anesthesiology I
  17. 2026, Undergraduate Education, 2Term, Oral Surgery and Anesthesiology II
  18. 2026, Undergraduate Education, 1Term, Oral Health Management
  19. 2026, Undergraduate Education, 2Term, Basic Training for Assistant Work in Dental Treatment III
  20. 2026, Undergraduate Education, 4Term, Social Welfare
  21. 2026, Undergraduate Education, 3Term, Basic Training for Assistant Work in Dental Treatment IV
  22. 2026, Undergraduate Education, 4Term, Basic Training for Assistant Work in Dental Treatment V
  23. 2026, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  24. 2026, Undergraduate Education, Second Semester, Special Study for Graduation
  25. 2026, Undergraduate Education, Intensive, Clinical Practice on Oral Health
  26. 2026, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  27. 2026, Undergraduate Education, Intensive, Special Study for Graduation
  28. 2026, Undergraduate Education, 1Term, Oral Health
  29. 2026, Undergraduate Education, 1Term, Oral Surgery and Anesthesiology I
  30. 2026, Undergraduate Education, 2Term, Oral Surgery and Anesthesiology II
  31. 2026, Graduate Education (Master's Program) , First Semester, Lecture on Oral Health Sciences
  32. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Oral Health
  33. 2026, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Oral Health
  34. 2026, Graduate Education (Master's Program) , First Semester, Lecture on Oral Health Research
  35. 2026, Graduate Education (Master's Program) , First Semester, Seminar on Oral Health Research (B)
  36. 2026, Graduate Education (Master's Program) , Second Semester, Seminar on Oral Health Research (B)
  37. 2026, Graduate Education (Master's Program) , First Semester, Research on Oral Health
  38. 2026, Graduate Education (Master's Program) , Second Semester, Research on Oral Health

Research Activities

Academic Papers

  1. Porphyromonas gingivalis-derived lipopolysaccharide confers chemotherapy resistance and migratory ability on oral cancer cells by activating toll-like receptor 4 signaling pathway, MOLECULAR BIOLOGY REPORTS, 53(1), 20260327
    Link to Paper Search Results by DOI
  2. Effects of glycyrrhizin on healing and prevention of recurrent aphthous stomatitis in hamster models, PLOS ONE, 21(1), 20260116
    Link to Paper Search Results by DOI
  3. Analysis of multimodal large language models on visually-based questions in the Japanese National Examination for Dental Hygienists: A preliminary comparative study, JOURNAL OF DENTAL SCIENCES, 21(1), 198-205, 202601
    Link to Paper Search Results by DOI
  4. Relationship Between Virulence Factor Activities, Cytotoxicity of Candida albicans Strains Isolated from Oral Cavity, and Cytokine Production by Oral Keratinocytes Exposed to Those Strains, DENTISTRY JOURNAL, 13(11), 20251029
    Link to Paper Search Results by DOI
  5. Presence of oral Helicobacter pylori DNA and its association with dental hygiene in older adults, World Academy of Sciences Journal, 7(6), 126, 2025
    Link to Paper Search Results by DOI
  6. Change in the Pattern of Tuft-Level Wear in Wide-Head Manual Toothbrushes After Use: A Prospective Cohort Pilot Study., Cureus, 17(8), e90658, 2025
    Link to Paper Search Results by DOI
  7. Establishment of immortalized human minor salivary gland cells and chemokine expression induced by IFN-γ, TNF-α, and IL-1β, ODONTOLOGY, 113(4), 1546-1557, 202510
    Link to Paper Search Results by DOI
  8. BECN1 Is Involved in Spheroid Formation and Resistance to 5-FU-Induced Cytotoxicity in CD44high Oral Cancer Cells, ORAL SCIENCE INTERNATIONAL, 22(2), 202505
    Link to Paper Search Results by DOI
  9. Cross-sectional pilot study of relationships between specific oral bacteria and acute respiratory failure requiring intensive care unit admission, JOURNAL OF DENTISTRY, 157, 202506
    Link to Paper Search Results by DOI
  10. Effects of Nisin A Combined with Antifungal Drug Against Growth of Candida Species, DENTISTRY JOURNAL, 13(4), 20250408
    Link to Paper Search Results by DOI
  11. Relationship between the presence of oral herpes simplex virus type 1 DNA and oral hygiene condition in dependent older individuals, ORAL SCIENCE INTERNATIONAL, 22(1), 202501
    Link to Paper Search Results by DOI
  12. Effects of Cigarette Smoke Extract on CXCL8 and CXCL1 Expression in oral Keratinocytes Induced by Synthetic Bacterial Lipoprotein Pam3CSK4, ORAL SCIENCE INTERNATIONAL, 22(2), 202505
    Link to Paper Search Results by DOI
  13. TMPRSS2 expression in oral mucosal cells induced by transfected double-stranded RNA and IL-1β, JOURNAL OF ORAL BIOSCIENCES, 67(2), 202506
    Link to Paper Search Results by DOI
  14. Periodontitis and postoperative inflammation in gastric cancer patients: Propensity score analysis, ORAL DISEASES, 30(7), 4691-4704, 202410
    Link to Paper Search Results by DOI
  15. Anti-fungal effects of slightly acidic electrolyzed water on Candida species, JOURNAL OF ORAL BIOSCIENCES, 67(1), 202503
    Link to Paper Search Results by DOI
  16. Carcinoma ex pleomorphic adenoma primarily composed of squamous cell carcinoma in buccal region - Case report, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 37(1), 99-103, 202501
    Link to Paper Search Results by DOI
  17. Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan, SCIENTIFIC REPORTS, 14(1), 20240515
    Link to Paper Search Results by DOI
  18. ACE2 expression and spike S1 protein-mediated immune responses in oral mucosal cells, ORAL DISEASES, 30(4), 2293-2305, 202405
    Link to Paper Search Results by DOI
  19. Manual toothbrushes, self-toothbrushing, and replacement duration to remove dental plaque and improve gingival health: A scoping review from recent research, JOURNAL OF DENTISTRY, 148, 202409
    Link to Paper Search Results by DOI
  20. Prevalence of oral Capnocytophaga species and their association with dental plaque accumulation and periodontal inflammation in middle-aged and older people, BIOMEDICAL REPORTS, 20(6), 202406
    Link to Paper Search Results by DOI
  21. ★, HPV16 E6 and E7 are involved in inhibition of autophagy and maintenance of cancer stem cell properties in HPV16-positive oral squamous cell carcinoma cells, ORAL SCIENCE INTERNATIONAL, 21(2), 207-218, 202405
    Link to Paper Search Results by DOI
  22. The prevalence of oral herpes simplex virus type 1 and its association with oral hygiene and periodontal condition, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 17(3), 41-46, 2024
  23. Sunitinib promotes apoptosis via p38 MAPK activation and STAT3 downregulation in oral keratinocytes, ORAL DISEASES, 30(2), 639-649, 202403
    Link to Paper Search Results by DOI
  24. Quality of life after tongue cancer treatment and its influencing factors: A cross-sectional study of Japanese patients, ORAL SCIENCE INTERNATIONAL, 21(1), 84-92, 202401
    Link to Paper Search Results by DOI
  25. Effectiveness of e-learning to promote oral health education: A systematic review and meta-analysis, MEDICINE, 102(51), 202312
    Link to Paper Search Results by DOI
  26. Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study, JOURNAL OF PERSONALIZED MEDICINE, 13(11), 202311
    Link to Paper Search Results by DOI
  27. Development and evaluation of the "Toothbrushing Timer with Information on Toothbrushes" application: A prospective cohort pilot study, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 9(6), 1206-1213, 202312
    Link to Paper Search Results by DOI
  28. Head and neck cancer patients show poor oral health as compared to those with other types of cancer, BMC ORAL HEALTH, 23(1), 20230906
    Link to Paper Search Results by DOI
  29. ★, Association between human papillomavirus and oral cancer: a literature review, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 28(8), 982-989, 202308
    Link to Paper Search Results by DOI
  30. LL-37-dsRNA Complexes Modulate Immune Response via RIG-I in Oral Keratinocytes, INFLAMMATION, 46(3), 808-823, 202306
    Link to Paper Search Results by DOI
  31. Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/alpha-TCP Composites: An In Vitro Study, MATERIALS, 16(3), 202302
    Link to Paper Search Results by DOI
  32. Associations between Oral Human Herpesvirus-6 and-7 and Periodontal Conditions in Older Adults, LIFE-BASEL, 13(2), 202302
    Link to Paper Search Results by DOI
  33. ★, Prevalence and risk factors for oral HPV16/18 and candida in Japanese people without oral cancer or premalignant lesions, ORAL SCIENCE INTERNATIONAL, 20(1), 10-17, 202301
    Link to Paper Search Results by DOI
  34. Effects of CEACAM1 in oral keratinocytes on HO-1 expression induced by Candida beta-glucan particles, J Appl Oral Sci, 30, e20220158, 2022
  35. ★, Prevalence of oral Epstein-Barr virus and Porphyromonas gingivalis and their association with periodontal inflamed surface area: A cross-sectional study., Medicine (Baltimore), 101(43), e31282, 2022
  36. ★, Co-Infection of Oral Candida albicans and Porphyromonas gingivalis Is Associated with Active Periodontitis in Middle-Aged and Older Japanese People, MEDICINA-LITHUANIA, 58(6), 202206
    Link to Paper Search Results by DOI
  37. ★, Analysis of the Deflection, Bristle Splaying, and Abrasion of a Single Tuft of a Polybutylene Terephthalate Toothbrush after Use: A Randomized Controlled Trial, Materials, 15(14), 4890, 2022
  38. Expression of anti-fungal peptide, beta-defensin 118 in oral fibroblasts induced by C. albicans beta-glucan-containing particles, JOURNAL OF APPLIED ORAL SCIENCE, 30, 2022
    Link to Paper Search Results by DOI
  39. Melatonin enhances cisplatin-induced cell death through inhibition of DERL1 in mesenchymal-like CD44(high) OSCC cells, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 51(3), 281-289, 202203
    Link to Paper Search Results by DOI
  40. Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy, SCIENTIFIC REPORTS, 12(1), 20220215
  41. Two PARP13 isoforms are associated with induction of antiviral factors in oral mucosal cells, MOLECULAR MEDICINE REPORTS, 25(3), 106, 2022
  42. Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts, Oral Dis, 28(1), 150-163, 2022
  43. ★, Effects of miR-224-5p-enhanced downregulation of PANX1 on docetaxel-induced apoptosis in amoeboid-like CD44high oral cancer cells, European Journal of Oral Sciences, 129(5), e12812, 2021
  44. ★, The Associations of Periodontopathic Bacteria and Oral Candida with Periodontal Inflamed Surface Area in Older Adults Receiving Supportive Periodontal Therapy, Diagnostics (Basel), 11(8), 1397, 2021
  45. ★, Detection of HPV16 E6 DNA in periodontal pockets of middle-aged and older people, Oral Science International, 18(1), 50-55, 2021
  46. ★, Association of oral Epstein-Barr virus with periodontal health in Japanese adults, Exp Ther Med, 22(1), 76, 2021
  47. ★, The association of oral HPV16 infection with periodontal inflammation and the oral microbiome in older Japanese women, Exp Ther Med, 21(2), 167, 2021
  48. ★, TGF-beta1 induces amoeboid-to-mesenchymal transition of CD44high oral squamous cell carcinoma cells via miR-422a downregulation through ERK activation and Cofilin-1 phosphorylation, J Oral Pathol Med., 50(2), 155-164, 2021
  49. Effects of perioperative oral care on postoperative inflammation following heart valve surgery., Oral Dis, 27(6), 1542-1550, 2021
  50. ★, Relationship between oral and physical function and length of participation in long-term care prevention programs in community-dwelling older Japanese women, Eur Geriatr Med, 12(2), 387-395, 2021
  51. In vitro investigation of the cell compatibility and antibacterial properties of titanium treated with calcium and ozone., Dent Mater J, 40(3), 712-718, 2021
  52. Age-related changes in oral tactile and thermal sensation throughout adulthood, Odontology, 109(3), 710-718, 2021
  53. ★, Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review), Biomed Rep, 14(5), 40-40, 2021
  54. The squamous cell carcinoma cell line OM-1 retains both p75-dependent stratified epithelial progenitor potential and cancer stem cell properties., Biochem Biophys Rep, 26, 101003, 2021
  55. ★, Changes in Physical and Oral Function after a Long-Term Care Prevention Program in Community-Dwelling Japanese Older Adults, Healthcare, 9(6), 719, 2021
  56. ★, Measurement of bristle splaying of toothbrushes using digital imaging and evaluation of plaque removal efficacy over 3 months: A randomized controlled trial (RCT)., Int J Dent Hyg, 18(2), 173-181, 2020
  57. ★, Association of physical performance with oral function in older women participating in community-based health exercise programs, Clin Exp Dent Res, 6(3), 311-317, 2020
  58. Serum IgG antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke., Clin Exp Immunol, 200(3), 302-309, 2020
  59. ★, High Rate of Oral Candida Detection in Dependent Japanese Older People., Geriatrics (Basel), 5(1), pii: E21, 2020
  60. Morphological Evaluation of Bone by CT to Determine Primary Stability-Clinical Study., Materials (Basel), 13(11), E2605, 2020
  61. ★, Changes in the bristle stiffness of polybutylene terephthalate manual toothbrushes over 3 months: A randomized controlled trial., Materials (Basel), 13(12), E2802, 2020
  62. ★, Melatonin-induced miR-181c-5p enhances osteogenic differentiation and mineralization of human jawbone-derived osteoblastic cells, Mol Med Rep, 22, 3549-3558, 2020
  63. ★, Oral human cytomegalovirus prevalence and its relationships with periodontitis and Porphyromonas gingivalis in Japanese adults: a cross-sectional study., J Appl Oral Sci, 28, e20200501, 2020
  64. ★, Detection of oral bacteria on the tongue dorsum using PCR amplification of 16S ribosomal RNA and its association with systemic disease in middle-aged and elderly patients., Biomed Rep, 10(1), 70-76, 2019
  65. ★, Relationship of salivary occult blood with general and oral health status in employees of a Japanese department store., J Clin Med Res, 11(3), 179-187, 2019
  66. ★, Association of oral function with long-term participation in community-based oral exercise programs in older Japanese women. A cross-sectional study., J Clin Med Res, 11(3), 165-170, 2019
  67. Smoking and periodontal microorganisms, Japanese Dental Science Review, 55, 88-94, 2019
  68. Dental education and medical security in Indonesia, Vietnam and Canbodia: the home countries of International Dental Course students in Hiroshima University School of Dentistry., The Journal of Hiroshima University Dental Society, 51(1), 34-41, 2019
  69. Study on characteristics of various kinds of plaque scoring methods, The Journal of Hiroshima University Dental Society, 51(1), 7-14, 2019
  70. ★, Improvement of physical and oral function in communitydwelling older people after a 3-month long-term care prevention program including physical exercise, oral health instruction, and nutritional guidance, Clin Exp Dent Res, 5(6), 611-619, 2019
  71. ★, Effect of hydrogel stiffness on morphology and gene expression pattern of CD44high oral squamous cell carcinoma cells, Int J Clin Exp Pathol, 12(8), 2826-2836, 2019
  72. Candida albicans β-glucan-containing particles increase HO-1 expression in oral keratinocytes via ROS/p38MAPK/Nrf2 pathway., Infect Immun, 2018
  73. ★, High HPV16 E6 viral load in the oral cavity is associated with an increased number of bacteria: A preliminary study, Biomed Rep, 8(1), 59-64, 2018
  74. ★, Efficacy of cognitive-behavioral therapy for patients with temporomandibular disorder pain-systematic review of previous reports, Int J Clin Exp Med, 11(2), 500-509, 2018
  75. ★, Human papillomavirus type 16 (HPV16) DNA copy number in oral rinse samples from oral cavity cancer patients, 3, 1-5, 2018
  76. ★, Changes in bacterial number at different sites of oral cavity during perioperative oral care management in gastrointestinal cancer patients: preliminary study., J Appl Oral Sci, 26, e20170516, 2018
  77. ★, Self-check with plaque disclosing solution improves oral hygiene in schoolchildren living in a children’s home, Archives of Public Health, 76, 50, 2018
  78. ★, CD44high/ESAlow squamous cell carcinoma cell-derived prostaglandin E2 confers resistance to 5-fluorouracil-induced apoptosis in CD44high/ESAhigh cells, Int J Clin Exp Pathol, 11(5), 2356-2363, 2018
  79. Usefulness of Bacterial Count with Dielectrophoretic Impedance Measurement Method and Salivary Multi-Test System for Evaluation of Oral Health Status, 50(2), 69-76, 2018
  80. Differential regulation by IFN-gamma on TNF-alpha-induced chemokine expression in synovial fibroblasts from temporomandibular joint, MOLECULAR MEDICINE REPORTS, 16(5), 6850-6857, 201711
    Link to Paper Search Results by DOI
  81. TNF--induced IL-6 and MMP-9 expression in immortalized ameloblastoma cell line established by hTERT, ORAL DISEASES, 23(2), 199-209, 2017
    Link to Paper Search Results by DOI
  82. ★, Association of human papillomavirus (HPV) infection with oral cancer- review of recent research, 67(3), 149-159, 2017
  83. Initial Report of the Attempt to Develop New Oral Assessment as Information Sharing with Multi-disciplinary : Oral Assessment of Chemotherapy Patients in Hiroshima University Hospital, 49(2), 134-140, 2017
  84. A case of three impacted supernumerary teeth in the third molar region of the right maxilla, Japanese journal of oral and maxillofacial surgery, 63(2), 83-86, 2017
  85. ★, Preoperative oral health care reduces postoperative inflammation and complications in oral cancer patients, Exp Ther Med, 2016
  86. ★, CD44high/ALDH1high head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3β-dependent cancer stem cell properties, J Oral Pathol Med, 2016
    Link to Paper Search Results by DOI
  87. ★, Professional oral health care reduces duration of hospital stay in patients undergoing orthognathic surgery, Biomedical Reports, 4(1), 55-58, 2016
  88. ★, Combined effects of melatonin and FGF-2 on mouse preosteoblast behavior within interconnected porous hydroxyapatite ceramics - in vitro analysis, J Appl Oral Sci, 24(2), 153-161, 2016
    Link to Paper Search Results by DOI
  89. ★, Risk factors for oral human papillomavirus (HPV) infection in healthy individuals: a systematic review and meta-analysis, Journal of Clinical Medicine Research, 8(10), 721-729, 2016
  90. ★, Association of temporomandibular disorder with occupational visual display terminal use: literature review, Biomedical Reports, 5(1), 7-10, 2016
    Link to Paper Search Results by DOI
  91. ★, Higher prevalence and gene amplification of HPV16 in oropharynx as compared to oral cavity, Journal of Applied Oral Science, 24(4), 397-403, 2016
  92. ★, Snail-induced CD44high cells in HNSCC with high ABC transporter capacity exhibit potent resistance to cisplatin and docetaxel., International Journal of Clinical and Experimental Pathology, 9(8), 7908-7918, 2016
  93. ★, Elevation in 5-FU-induced apoptosis in Head and Neck Cancer Stem Cells by a combination of CDHP and GSK3 beta inhibitors, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 44(3), 201-207, 2015
    Link to Paper Search Results by DOI
  94. ★, Clinicopathological analysis of salivary gland carcinomas and literature review, Mol Clin Oncol, 3(1), 202-206, 2015
  95. ★, Risk factors for postoperative complications following oral surgery, J Appl Oral Sci, 2015
    Link to Paper Search Results by DOI
  96. ★, Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers (review), JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 140(10), 1629-1640, 201410
    Link to Paper Search Results by DOI
  97. Expression and Function of RIG-I in Oral Keratinocytes and Fibroblasts, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 34(5), 1556-1565, 2014
    Link to Paper Search Results by DOI
  98. Clinical study of application of polyglycoloic acid sheet and fibrin glue splay in surgical resection for oral cancer, The Journal of Hiroshima University Dental Society, 46(2), 136-142, 2014
  99. Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 441(4), 904-910, 20131129
    Link to Paper Search Results by DOI
  100. ★, Maintenance of stem cell self-renewal in head and neck cancers requires actions of GSK3 beta influenced by CD44 and RHAMM, STEM CELLS, 31(10), 2073-2083, 201310
    Link to Paper Search Results by DOI
  101. AKT Primes Snail-Induced EMT Concomitantly With the Collective Migration of Squamous Cell Carcinoma Cells, JOURNAL OF CELLULAR BIOCHEMISTRY, 114(9), 2039-2049, 201309
    Link to Paper Search Results by DOI
  102. Expression of receptor for hyaluronan-mediated motility (RHAMM) in ossifying fibromas, HISTOLOGY AND HISTOPATHOLOGY, 28(4), 473-480, 201304
    Link to Paper Search Results by DOI
  103. Interleukin-8 and CXCL10 expression in oral keratinocytes and fibroblasts via Toll-like receptors, MICROBIOLOGY AND IMMUNOLOGY, 57(3), 198-206, 201303
    Link to Paper Search Results by DOI
  104. Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma, CANCER LETTERS, 329(2), 243-252, 20130228
    Link to Paper Search Results by DOI
  105. Risk of bacterial contamination of bone harvesting devices used for autogenous bone graft in implant surgery, HEAD & FACE MEDICINE, 9, 20130111
    Link to Paper Search Results by DOI
  106. ★, Features of cancer stem cell in oral squamous cell carcinomas, The Japanese journal of Tissue Culture Society for Dental Research, 22(2), 1-5, 2013
  107. A Case Study of Dental Implant Placements by Splitting the Alveolar Crest and Using Interconnected Porous Calcium Hydroxyapatite, The Journal of Hiroshima University Dental Society, 45(2), 124-127, 2013
  108. Establishment of mesenchymal cell line derived from human developing odontoma, ORAL DISEASES, 18(8), 756-762, 201211
    Link to Paper Search Results by DOI
  109. Overexpression of receptor for hyaluronan-mediated motility (RHAMM) in MC3T3-E1 cells induces proliferation and differentiation through phosphorylation of ERK1/2, JOURNAL OF BONE AND MINERAL METABOLISM, 30(3), 293-303, 201205
    Link to Paper Search Results by DOI
  110. A Case of SAPHO Syndrome With Diffuse Sclerosing Osteomyelitis of the Mandible Treated Successfully With Prednisolone and Bisphosphonate, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 70(3), 626-631, 201203
    Link to Paper Search Results by DOI
  111. ★, Clinical evaluation of novel interconnected porous hydroxyapatite ceramics (IP-CHA) in a maxillary sinus floor augmentation procedure, DENTAL MATERIALS JOURNAL, 31(1), 54-60, 201201
    Link to Paper Search Results by DOI
  112. A case of calcifying cystic odontogenic tumor occurring in a 92-year-old woman, Japanese Journal of Oral and Maxillofacial Surgery, 58(5), 327-331-331, 2012
  113. Questionnaire Survey about Uneasiness and Satisfaction to Bone Augmentation Surgery for Oral Implant, 44(1), 29-35, 2012
  114. ★, PGE2 targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction, CANCER LETTERS, 307(2), 227-236, 20110828
    Link to Paper Search Results by DOI
  115. ★, RHAMM/ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR, LABORATORY INVESTIGATION, 91(3), 379-391, 201103
    Link to Paper Search Results by DOI
  116. ★, Increased telomerase activity and hTERT expression in human salivary gland carcinomas, ONCOLOGY LETTERS, 2(5), 845-850, 2011
    Link to Paper Search Results by DOI
  117. Molecular and pathologic analysis of human cementifying fibroma, TISSUE CULTURE RESEARCH COMMUNICATIONS, 30(2-3-4), 135-143, 2011
  118. Treatment for the maxillofacial traumatic injured patients with dental implant, J. Jpn. Soc. O.M.F. Trauma, 10(2), 53-59, 2011
  119. Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas., Oncol Rep, 24(1), 9-14, 2010
  120. Influence of factors related to implant stability detected by wireless resonance frequency analysis device., J Oral Rehabil, 37(2), 131-137, 2010
    Link to Paper Search Results by DOI
  121. CX3CL1 expression induced by Candida albicans in oral fibroblasts., FEMS Immunol Med Microbiol, 60(2), 179-185, 2010
    Link to Paper Search Results by DOI
  122. ★, Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 34(6), 1565-1571, 200906
    Link to Paper Search Results by DOI
  123. ★, Amphiregulin Induces Proliferative Activities in Osseous Dysplasia, JOURNAL OF DENTAL RESEARCH, 88(6), 563-568, 200906
    Link to Paper Search Results by DOI
  124. ★, Expression of TPX2 in salivary gland carcinomas, ONCOLOGY REPORTS, 21(2), 341-344, 2009
    Link to Paper Search Results by DOI
  125. DeltaNp63alpha-dependent expression of Id-3 distinctively suppresses the invasiveness of human squamous cell carcinoma., Int J Cancer, 124(12), 2837-2844, 2009
    Link to Paper Search Results by DOI
  126. ★, CENPF (centromere protein F, 350/400ka (mitosin)) Mini Review., Atlas of Genetics and Cytogenetics in Oncology and Haematology, 13(2), 106-109, 2009
    Link to Paper Search Results by DOI
  127. Up-regulation of stromal cell-derived factor-1 alpha and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma, ONCOLOGY REPORTS, 19(4), 993-998, 200804
    Link to Paper Search Results by DOI
  128. Application of three-dimensional model for oral and maxillofacial surgery, The Journal of Hiroshima University Dental Society, 40(1), 55-61, 2008
  129. Regulation of CXCL9/10/11 in oral keratinocytes and fibroblasts., J Dent Res, 87(12), 1160-1165, 2008
  130. ★, Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas., Oncol Rep, 19(6), 1557-1564, 2008
  131. Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition., Cancer Lett, 264(2), 256-264, 2008
    Link to Paper Search Results by DOI
  132. ★, Increased Expression of CENP-H Gene in Human Salivary Gland Carcinomas, Oral science international, 5(1), 43-51, 2008
  133. Effect of cortical bone on dental implant stability quotient values, Journal of Japanese Society of Oral Implantology, 21(2), 2008
  134. Human papillomavirus-16 in oral squamous cell carcinoma: Clinical correlates and 5-year survival. British Journal of Oral & Maxillofacial Surgery, British Journal of Oral & Maxillofacial Surgery, 45, 116-122, 2007
  135. Snail-induced down-regulation of Delta Np63 alpha acquires invasive phenotype of human squamous cell carcinoma, Cancer Research, 67(19), 9207-9213, 2007
  136. Two cases of maxillary distraction osteogenesis using rigid external distraction (RED) system and leipzig retention plate for maxillary hypoplasia, 39(2), 173-180, 2007
  137. A Case of Osteonecrosis of the Jaw Associated with Oral Application of Bisphosphonates, The Journal of Hiroshima University Dental Society, 39(2), 168-172, 2007
  138. Hemostatic management for tooth extraction in patients receiving anticoagulant therapy, The Journal of Hiroshima University Dental Society, 39(1), 19-23, 2007
  139. ★, A case of hemangioma in masseter muscle, The Journal of Hiroshima University Dental Society, 39(1), 62-64, 2007
  140. Evaluation of bone regeneration of osteoblasts derived from human jaw bone cultured on interconnected porous hydroxyapatite ceramics, Archives of Bioceramics Research, 7, 255-259, 2007
  141. ★, Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity, Oncology Report, 16, 1071-1075, 2006
  142. Immediate Reconstructive Surgery with Pedicle and Free Myocutaneous Flap after Oral Cancer Ablation, The Journal of Hiroshima University Dental Society, 38(2), 143-149, 2006
  143. ★, A case of aberrant tooth root in the maxillary sinus, The Journal of Hiroshima University Dental Society, 38(2), 167-169, 2006
  144. Application of contra-angle screwdriver system in the treatment of mandibular fractures, J. Jpn. Soc. O.M.F. Trauma, 5, 83-88, 2006
  145. ★, Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumor, Oral Oncology, 41, 716-722, 2005
  146. ★, Correlation between CENP-F mRNA expression and lymph node metastasis in oral squamous cell carcinomas, Japanese Journal of Oral & Maxillofacial Surgery, 51(2), 77-81, 2005
  147. Comparison of genes expressed in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the tongue, Japanese Journal of Oral & Maxillofacial Surgery, 51(10), 482-488, 2005
  148. A case of congenital tooth woth cleft uvula, Pediatric oral and maxillofacial surgery, 15(2), 2005
  149. A case of cemento-osseous dysplasia appearing to be a cystic lesion of the mandible on radiographs, Japanese Journal of Oral & Maxillofacial Surgery, 51(4), 184-187, 2005
  150. A case of jaw trismus caused by an isolated calcified mass in the temporal muscle and a hyperplasia-like lesion of the mandibular coronoid process, Japanese Journal of Oral & Maxillofacial Surgery, 51(11), 547-550, 2005
  151. A case of solitary plasmacytoma of the mandible with transition into multiple myeloma, The Journal of Hiroshima University Dental Society, 36(2), 209-212, 2004
  152. An infant case released from TMJ ankylosis by both of osteoarthrotomy and cutting-off of elongated muscular process, Pediatric oral and maxillofacial surgery, 13(2), 21-26, 2003
  153. Clinicopathologic Investigations of Seven Late Recurrences of 162 Oral Squamous Cell Carcinomas (1981 - 1990), The Journal of Hiroshima University Dental Society, 35(1), 125-129, 2003
  154. Clinicostatisticl Analyses of Epuliden, The Journal of Hiroshima University Dental Society, 35(1), 135-140, 2003
  155. Induction of hRAD9 is required for G2/M checkpoint signal transduction in gastric cancer cells, Pathobiology, 70(1), 40-46, 2002
  156. ★, Increased expression of CHK2 in human gastric carcinomas harboring p53 mutations, Int J Cancer, 99(1), 58-62, 2002
  157. Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer, J Pathol, 196(2), 163-170, 2002
  158. ★, No mutations of the Bub1 gene in human gastric carcinomas, Oncology Reports, 8, 791-794, 2001
  159. ★, Expression of Bub1 Gene Correlates with Tumor Proliferating Activity in Human Gastric Carcinomas., Pathobiology, 69, 24-29, 2001
  160. Prospective study of Ki-67 labeling index in the mucosa adjacent to cancer as a marker for colorectal cancer metastasis, J Exp Clin Cancer Res, 20(4), 543-548, 2001
  161. ★, Pleomorphic adenoma of the parotid gland with extensive bone formation, Pathol. Int., 51(11), 883-886, 2001
  162. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma, Int J Cancer, 93(6), 805-809, 2001

Invited Lecture, Oral Presentation, Poster Presentation

  1. The prevalence and risk factors for oral HPV16/18 in Japanese people., Shigeishi H, Sugiyama M, Ohta K, The 35th International Papillomavirus Conference,, 2023/04/18, Without Invitation, English
  2. Association between oral HPV prevalence and smoking in people without oral cancer. SYMPOSIA - TOBACCO OR ORAL HEALTH: TOBACCO DEPENDENCE TREATMENT BY ORAL HEALTH PROFESSIONALS., Hideo Shigeishi, 15th Annual Conference of the International Society for the Prevention of Tobacco Induced Diseases, 2019., 2019/10/13, Without Invitation, English, Tokyo
  3. Association of human papillomavirus (HPV) with oral cavity cancers. Review of recent research　, Hideo Shigeishi, The 62th Congress of the Japanese Society of Oral and Maxillofacial Surgeons. Work Shop., 2018/11/02, With Invitation, Japanese
  4. Correlation between oral HPV infection and clinicopathological parameters, Hideo Shigeishi, 2015/09/03, Without Invitation, Japanese
  5. The effectiveness of preoperative oral health care in oral cancer patients, Shigeishi H, The 64th general meeting of Japan society for oral health, 2015/05/28, Without Invitation, Japanese, Tsukuba
  6. The correlation between GSK3β and stemness properties in oral squamous cell carcinomas, Shigeishi H, The 67th Annual Meeting of the Japanese Stomatological Society, 2013, Without Invitation, Japanese, Utsunomiya
  7. The role of CD44-mediated signaling pathway in oral squamous cell cancer stem cells, Shigeishi H, The 49th Annual Meeting of Japan Tissue Culture Society for Dental Research, 2012, Without Invitation, Japanese
  8. CD44-related molecular events underline the choice between self-renewal and differentiation of cancer stem cells in OSCC, Shigeishi H, The 71th Annual Meeting of the Japanese Cancer Association, 2012, Without Invitation, Japanese
  9. Relevance of EMT in vitro models for OSCC invasion studies, Rondini C, Fazil B, Emich H, Bidle A, Gammon L, Gmmenetzidis E, Shigeishi H, Mackenzie C, IADR 90th General Session, 2012, Without Invitation, English, Brazil
  10. Expression and functional analysis of NR4A2 in human oral squamous cell carcinomas, Shigeishi H, The 64th Annual Meeting of the Japanese Stomatological Society., 2010, Without Invitation, Japanese
  11. PGE2-induced expression of NR4A2 confers anti-apototic capability, Shigeishi H, IADR 88th General Session, 2010, Without Invitation, English, Spain
  12. Expression analysis of RHAMM in oral squamous cell carcinomas, Shigeishi H, 53th Congress of the Japanese Society of Oral and Maxillofacial Surgeons, 2008, Without Invitation, Japanese, Tokushima
  13. Analysis of growth mechanisms and marker gene of osseous dysplasia cells, Shigeishi H, The 25th Annual Meeting of Japan Society for Oral Tumors, 2007, Without Invitation, Japanese, Nagoya
  14. The search for marker gene of ossifying fibroma derived cells by comprehensively analyzing the gene expression, Shigeishi H, The 52th Annual Meeting of the Japanese Stomatological Society, 2007, Without Invitation, Japanese
  15. Expression analysis of Bubl,BubR1 and Bub3 gene in human salivary gland carcinomas, Shigeishi H, The 57th Annual Meeting of the Japanese Stomatological Society, 2006, Without Invitation, Japanese
  16. Expression analysis of CENP-H in oral squamous cell carcinomas, Shigeishi H, The 64th Annual Meeting of the Japanese Cancer Association, 2006, Without Invitation, Japanese
  17. Characterization and exhaustive gene expression analysis of osseous dysplasia cells derived from Gnathodiaphyseal Dysplasia, Shigeishi H, The 51th Congress of the Japanese Society of Oral and Maxillofacial Surgeons, 2006, Without Invitation, Japanese
  18. Expression analysis of CENP-H gene in oral squamous cell carcinomas, Shigeishi H, The 57th Annual Meeting of the Japanese Stomatological Society, 2005, Without Invitation, Japanese
  19. Expression analysis of CENP-F in salivary gland tumors, Shigeishi H, The 64th Annual Meeting of the Japanese Cancer Association, 2005, Without Invitation, Japanese

Awards

  1. 2018/05/26, Encouragement Award, Alumni association of Hiroshima University Faculty of Dentistry
  2. 2008, Gold ribbon award winner for the 53th Congress of the Japanese Society of Oral and Maxillofacial Surgeons, Japanese Society of Oral and Maxillofacial Surgeons

External Funds

Acceptance Results of Competitive Funds

  1. 2023, 2025