Last Updated :2024/04/03

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
Other Contact Details
1-2-3,Kasumi,Minami-ku,Hiroshima 734-8551, Japan
TEL : (+81)82-257-1583 FAX : (+81)82-257-1584
I was born and grew up in Hiroshima, and graduated from Hiroshima University. Now, I'm working for Hiroshima University Hospital. I want to contribute to the advance of medical care quality in Hiroshima.

Basic Information

Major Professional Backgrounds

  • 2011/04/01, 2013/03/31, Hiroshima University Hospital, Clinical Resident
  • 2013/04/01, 2015/03/31, Rakuwakai Marutamachi Hospital, Clinical Resident
  • 2015/04/01, 2016/03/31, Hiroshima University Hospital, Department of Clinical Immunology and Rheumatology, Doctor
  • 2016/04/01, Hiroshima University Hospital, Department of Clinical Immunology and Rheumatology, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Facuity of Medicine, Japan, 2005/04, 2011/03

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Educational Activity

  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Collagenous pathology / Allergology

Research Keywords

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Collagenous pathology / Allergology

Affiliated Academic Societies

  • The Japan Society of Human Genetics
  • Japan College of Rheumatology
  • The Japanese Society of Internal Medicine
  • The Japanese Association for Infectious Diseases

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine II

Research Activities

Academic Papers

  1. Disseminated Mycobacterium abscessus infection with osteoarticular manifestations as an important differential diagnosis of inflammatory arthritis: A case report and literature review, MODERN RHEUMATOLOGY CASE REPORTS, 8(1), 49-54, 20231229
  2. Long-Term Prognosis of Antimelanoma Differentiation-Associated Gene 5-Positive Dermatomyositis With Interstitial Lung Disease, The Journal of Rheumatology, 50(11), 1454-1461, 202311
  3. Tumor Necrosis Factor and Interleukin-1 beta Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation, VIRUSES-BASEL, 15(7), 202307
  4. Cryoglobulinemic Vasculitis Associated with Monoclonal Gammopathy of Undetermined Significance Developed after Sustained Virologic Response of Hepatitis C, INTERNAL MEDICINE, 62(13), 1999-2004, 2023
  5. Safe Introduction of Hydroxychloroquine Focusing on Early Intolerance Due to Adverse Drug Reactions in Patients with Systemic Lupus Erythematosus, INTERNAL MEDICINE, 62(14), 2051-2057, 2023
  6. Fluorodeoxyglucose-positron emission tomography/computed tomography-positive ear lesions responsive to immunosuppressive therapy in a patient with otitis media with antineutrophil cytoplasmic antibody-associated vasculitis, MODERN RHEUMATOLOGY CASE REPORTS, 7(1), 134-137, 20230103
  7. Appearance of anti-MDA5 antibody-positive dermatomyositis after COVID-19 vaccination, MODERN RHEUMATOLOGY CASE REPORTS, 7(1), 108-112, 20230103
  8. A case of ischemic stroke associated with protein-losing gastroenteropathy and protein S deficiency, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 32(7), 202307
  9. ★, Seasonal influence on development of anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective cohort study conducted at multiple institutions in Japan (J-CANVAS), The Journal of Rheumatology, 50(9), 1152-1158, 202309
  10. Association between increased serum IL-23 levels and ACPA positivity in patients with rheumatoid arthritis, Clinical and Experimental Rheumatology, 41(5), 1198-1199, 202305
  11. Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report, American Journal of Case Reports, 20230521
  12. Portal Vein Thrombosis as a Cause of Undetermined Thrombocytopenia with Liver Dysfunction in a Patient with Eosinophilic Granulomatosis with Polyangiitis, INTERNAL MEDICINE, 62(1), 123-127, 20230101
  13. Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling, INFLAMMATION AND REGENERATION, 43(1), 20230106
  14. Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19, JOURNAL OF CLINICAL IMMUNOLOGY, 42(7), 1360-1370, 202210
  15. Dupilumab as an adjunct treatment for a patient with steroid-dependent immunoglobulin G4-related disease complicated by asthma: a case report, JOURNAL OF ASTHMA, 59(12), 2395-2401, 20221110
  16. Association between CA 15-3 and progression of interstitial lung disease in a case of coexisting systemic sclerosis and recurrent breast cancer: A case report, MOLECULAR AND CLINICAL ONCOLOGY, 17(4), 202210
  17. Bilateral facial nerve palsy responded to immunosuppressive therapy in a patient with eosinophilic granulomatosis with polyangiitis, Rheumatol Adv Pract, 20220829
  18. Exacerbation of systemic lupus erythematosus after receiving mRNA-1273-based coronavirus disease 2019 vaccine, J Dermatol, 202206
  19. Comment on: Combination of immunosuppressive therapy and nintedanib improves capillaroscopic changes in systemic sclerosis-interstitial lung disease: a case report, Rheumatol Adv Pract, 20220531
  20. Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis, RHEUMATOLOGY, 61(5), 2006-2015, 20220505
  21. Comment on: Nailfold capillaries and myositis-specific antibodies in anti-melanoma differentiation-associated gene 5 antibody-positive DM. Reply, Rheumatology(Oxford), 20220505
  22. ★, C-reactive protein and ground-glass opacity as predictors for intractable interstitial lung disease in patients with systemic sclerosis under cyclophosphamide treatment regardless of concomitant glucocorticoids, MODERN RHEUMATOLOGY, 32(1), 141-148, 20220105
  23. The Efficacy of Amenamevir for the Treatment of Disseminated Herpes Zoster Complicated with Probable Varicella-zoster Pneumonia in an Immunocompromised Patient, INTERNAL MEDICINE, 61(11), 1785-1788, 2022
  24. The Lipopolysaccharide Mutant Re-LPS Is a Useful Tool for Detecting LPS Contamination in Rheumatoid Synovial Cell Cultures, Pathobiology, 89(2), 92-100, 2022
  25. A Rare Case of IgG4-Related Disease Presenting as a Unilateral Severe Dacryoadenitis Complicated by Hypophysitis and Hypertrophic Pachymeningitis, J Clin Rheumatol, 20211201
  26. Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene, MODERN RHEUMATOLOGY CASE REPORTS, 5(1), 130-136, 20210102
  27. Rapid changes of nailfold capillary abnormalities during treatment for a patient with dermatomyositis complicated by lung cancer: a case report, MODERN RHEUMATOLOGY CASE REPORTS, 5(1), 95-100, 20210102
  28. Tapering and discontinuation of oral glucocorticoids without deterioration of disease status in patients with rheumatoid arthritis under a stable treatment, MODERN RHEUMATOLOGY, 31(4), 803-808, 20210704
  29. The clinical characteristics and predictors of severe digital ischemia in patients with anti-aminoacyl transfer RNA synthetase antibodies, JOURNAL OF DERMATOLOGY, 48(7), 1044-1051, 202107
  30. Immunoglobulin D-kappa multiple myeloma in a patient with rheumatoid arthritis: a case report and review of the literature, MODERN RHEUMATOLOGY CASE REPORTS, 5(1), 22-28, 20210102
  31. ★, Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study, MODERN RHEUMATOLOGY, 31(3), 643-648, 20210504
  32. TGF beta 1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(3), 202002
  33. Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNF alpha-Induced CXCL10 Expression and Osteoclastogenesis, PATHOBIOLOGY, 87(3), 198-207, 2020
  34. Serum CXCL10 levels are associated with better responses to abatacept treatment of rheumatoid arthritis, CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 38(5), 956-963, 2020
  35. Coexisting TIF1 gamma-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1 gamma Antibody-positive Dermatomyositis, INTERNAL MEDICINE, 59(20), 2553-2558, 2020
  36. Large-vessel vasculitis associated with PEGylated granulocyte-colony stimulating factor, NETHERLANDS JOURNAL OF MEDICINE, 77(6), 224-226, 201907
  37. Multiple External Root Resorption of Teeth as a New Manifestation of Systemic Sclerosis-A Cross-Sectional Study in Japan, JOURNAL OF CLINICAL MEDICINE, 8(10), 201910
  38. A large deep skin ulcer as an initial manifestation of systemic cryptococcosis., Mycopathologia, 184(2), 341-343, 2019
  39. Tumor necrosis factor α augments the inhibitory effects of CTLA-4-Ig on osteoclast generation from human monocytes via induction of CD80 expression., Clin Exp Immunol, 196(3), 392-402, 2019
  40. ★, IL-1β Enhances Wnt Signal by Inhibiting DKK1., Inflammation, 41(5), 1945-1954, 2018

Invited Lecture, Oral Presentation, Poster Presentation

  1. The association of fecal calprotectin levels and clinical characteristics in patients with connective tissue diseases with gastrointestinal symptoms: A retrospective study, 2023/04, Without Invitation, English
  2. Higher prevalence of anti-Stress Granule antibodies in patients with anti-nuclear antibodies-negative rheumatic diseases, The Asia Pacific League of Associations for Rheumatology (APLAR), 2023/12, Without Invitation, English
  3. IgG4-related disease with bone marrow involvement as a possible cause of anemia., Yusuke Yoshida, Tomohiro Sugimoto, Shintaro Hirata, The 4th International Symposium on IgG4-Related Diseases, 2021/12, Without Invitation, English
  4. Poor additive effects of glucocorticoids combined with intravenous cyclophosphamide against systemic sclerosis-related interstitial lung disease., Yusuke Yoshida, Tomohiro Sugimoto, Yohei Hosokawa, Harumichi Suma, Hiroki Kobayashi, Michinori Ishitoku, Hiroki Kohno, Tadahiro Tokunaga, Hirofumi Watanabe, Sho Mokuda, Takaki Nojima, Shintaro Hirata, Eiji Sugiyama, 2021/04, Without Invitation, English
  5. Lower CH50 as a Predictor for Intractable or Recurrent Lupus Enteritis., Yusuke Yoshida, Tomohiro Sugimoto, Shintaro Hirata, Eiji Sugiyama, The Asia Pacific League of Associations for Rheumatology (APLAR), 2020/10/24, Without Invitation, English
  6. Predictive factors for recurrence or insufficient response to initial treatment in patients with lupus enteritis., Yusuke Yoshida, Takuji Omoto, Hirofumi Watanabe, Tomohiro Sugimoto, Sho Mokuda, Shintaro Hirata, Eiji Sugiyama, 2020/08/17, Without Invitation, English
  7. Predictive factors for insufficient response to initial treatment or recurrence in patients with lupus enteritis., Yusuke Yoshida,Tomohiro Sugimoto,Hiroki Kohno, Hirofumi Watanabe,Sho Mokuda,Shintaro Hirata,Eiji Sugiyama, Annual European Congress of Rheumatology (EULAR 2020), 2020/06/03, Without Invitation, English
  8. DIFFERENCE OF IMAGE FEATURES ON COMPUTED TOMOGRAPHY BETWEEN LUPUS ENTERITIS AND MESENTERIC VASCULITIS OF OTHER CONNECTIVE TISSUE DISEASES., Y. Yoshida, T. Kondo, K. Yukawa, T.Tokunaga,T. Kuranobu, K. Oi, T.Nojima, S. Hirata,E. Sugiyama, Annual European Congress of Rheumatology (EULAR 2018), 2018/06, Without Invitation, English, Amsterdam,Netherlands
  9. Predictive Factors of Cytomegalovirus Infection in Patients with Connective Tissue Diseases Treated with Immunosuppressive Drugs., Yusuke Yoshida,Hiroki Kohno,Katsuhiro Oi,Tadahiro Tokunaga,Tatsuomi Kuranobu,Takaki Nojima,Shintaro Hirata,Eiji Sugiyama, ACR/ARHP Annual Meeting (ACR2017), 2017/11, Without Invitation, English, San Diego,USA
  10. interleukin-1β Stabilize CXCL2mRNA and increase its Expression., Satoshi Yamasaki, Yusuke Yoshida and Eiji Sugiyama, ACR/ARHP Annual Meeting (ACR 2016), 2016/11, Without Invitation, English, Washington, D.C., USA
  11. Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-love Synoviocytes., Yusuke Yoshida and Satoshi Yamasaki., ACR/ARHP Annual Meeting (ACR2015), 2015/11, Without Invitation, English, San Francisco, USA


  1. 2023/11/21, The 25th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2023) Travel Grant, Asia Pacific League of Associations for Rheumatology

Social Activities

History as Peer Reviews of Academic Papers

  1. 2024, Modern Rheumatology, Others, 1
  2. 2023, Modern Rheumatology, Others, 1
  3. 2023, Journal of Thoracic Disease, Others, 1
  4. 2023, Scientific Reports, Others, 1
  5. 2023, Expert Review of Clinical Immunology, Others, 1
  6. 2023, Modern Rheumatology Case Reports, Others, 4
  7. 2022, BMJ Case Reports, Others, 2
  8. 2021, BMJ Case Reports, Others, 1
  9. 2021, Modern Rheumatology, Others, 1
  10. 2021, Modern Rheumatology Case Reports, Others, 2
  11. 2020, Modern Rheumatology Case Reports, Others, 2
  12. 2019, Journal of Internal Medicine, Others, 1
  13. 2019, Medical Science Monitor, Others, 1