FUMIKO HIGASHIKAWA

Last Updated :2026/09/09

Affiliations, Positions
Future Medical Care Center, Associate Professor (Special Designation)
Web Site
https://healthy-life.hiroshima-u.ac.jp/english.html
https://www.researchgate.net/profile/Fumiko-Higashikawa
E-mail
fumikohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2022/04/01, Hiroshima University Hospital, Medical Center for Translational and Clinical Research, Associate Senior Research Manager by Special Appointment, Associate Professor by Special Designation (2026/4/1-)
  • 2010/04/01, 2022/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor by Special Appointment
  • 2007/04/01, 2010/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Contributing Associate Professor
  • 2002/09/01, 2006/03/31, Hiroshima University, Graduate School of Biomedical Sciences, Research Assistant
  • 2002/04/01, 2002/08/31, Hiroshima University, Research Institute for Radiation Biology and Medicine, Research Assistant
  • 2001/01/01, 2002/03/31, University of California, San Francisco (UCSF), Dept. Laboratory Medicine, Postdoctoral Fellow
  • 1999/04/01, 2001/01/31, University of Florida, Dept. Molecular Genetics & Microbiology, Gene Therapy Center, Postdoctoral Associate

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1996/04, 1999/03
  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1994/04, 1996/03
  • Hiroshima University, Faculty of Medicine, Japan, 1990/04, 1994/03

Academic Degrees

  • Hiroshima University
  • Hiroshima University

In Charge of Primary Major Programs

  • Pharmaceutical Sciences
  • Medicinal Sciences

Research Fields

  • Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy

Research Keywords

  • Clinical Research on Functional Foods, Gut microbiome

Affiliated Academic Societies

Research Activities

Academic Papers

  1. ★, Individual variability in hydrogen-producing microbes influences the response to hydrogen supplementation on sleep quality: a randomized, double-blind, placebo-controlled, parallel study., Scientific reports, 16(1), 2026
    Link to Paper Search Results by DOI
  2. ★, Beneficial Effects of Ginger Extract on Eye Fatigue and Shoulder Stiffness: A Randomized, Double-Blind, and Placebo-Controlled Parallel Study., Nutrients, 16(16), 2024
    Link to Paper Search Results by DOI
  3. ★, Reduction of fatigue and anger-hostility by the oral administration of 5-aminolevulinic acid phosphate: a randomized, double-blind, placebo-controlled, parallel study, SCIENTIFIC REPORTS, 10(1), 2020
    Link to Paper Search Results by DOI
  4. ★, Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial, EUROPEAN JOURNAL OF CLINICAL NUTRITION, 70(5), 582-587, 2016
    Link to Paper Search Results by DOI
  5. ★, The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice, PLOS ONE, 7(2), e30696, 2012
    Link to Paper Search Results by DOI
  6. ★, Improvement of constipation and liver function by plant-derived lactic acid bacteria: A double-blind, randomized trial, NUTRITION, 26(4), 367-374, 2010
    Link to Paper Search Results by DOI
  7. ★, Kinetic analyses of stability of simple and complex retroviral vectors., Virology, 280(1), 124-131, 2001
    Link to Paper Search Results by DOI
  8. Matcha alleviates sneezing response in a murine model of allergic rhinitis., NPJ science of food, 10(1), 2026
    Link to Paper Search Results by DOI
  9. Relationship between Corvis ST tonometry parameters and mean blur rate in the optic nerve head tissue area in healthy eyes., PloS one, 21(6), 2026
    Link to Paper Search Results by DOI
  10. ★, Temporal transition in urine and plasma porphyrin levels following 5-aminolevulinic acid administration in healthy adults., Photodiagnosis and photodynamic therapy, 56, 2025
    Link to Paper Search Results by DOI
  11. ★, Safety of Oral Administration of 5-Aminolevulinic Acid Phosphate Combined with Ferrous Iron in Healthy Subjects: An Open-Label Trial, Scientia Pharmaceutica, 93, 2025
    Link to Paper Search Results by DOI
  12. Intelligibility Sound Therapy Enhances the Ability of Speech-in-Noise Perception and Pre-Perceptual Neurophysiological Response., Biology, 13(12), 2024
    Link to Paper Search Results by DOI
  13. Effect of Ocular Dominance on Ocular Blood Flow Parameters., Cureus, 15(10), 2023
    Link to Paper Search Results by DOI
  14. Plant-Derived Lactobacillus paracasei IJH-SONE68 Improves Chronic Allergy Status: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, NUTRIENTS, 13(11), 2021
    Link to Paper Search Results by DOI
  15. Lactobacillus plantarum SN13T Cells Improve Hepatic Dysfunction And Fecal Microbiota: A Randomized Pilot Study, Arch Clin Biomed Res, 4(6), 605-625, 2020
  16. Effect of Salacia oblonga Extract on Blood Pressure in High-Normal Blood Pressure or Grade I Hypertension Subjects: A Dose-Comparison, Pilot Study., Pharmacometrics, 98(3/4), 35-41, 2020
  17. Improvement of Alcohol-Poisoning Symptoms in Mice by the Oral Administration of Live Lactobacillus plantarum SN13T Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(5), 2020
    Link to Paper Search Results by DOI
  18. Interleukin-8 Release Inhibitors Generated by Fermentation ofArtemisia princepsPampanini Herb Extract WithLactobacillus plantarumSN13T, FRONTIERS IN MICROBIOLOGY, 11, 2020
    Link to Paper Search Results by DOI
  19. Quantifying Parkinson's disease finger-tapping severity by extracting and synthesizing finger motion properties, MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 54(6), 953-965, 2016
    Link to Paper Search Results by DOI
  20. Characterization and Mutational Analysis of a Two-Polypeptide Bacteriocin Produced by Citrus Iyo-Derived Lactobacillus brevis 174A, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38(12), 1902-1909, 2015
  21. ★, 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects, NUTRITION, 29(7-8), 1030-1036, 2013
    Link to Paper Search Results by DOI
  22. Crystallographic and mutational analyses of tannase from Lactobacillus plantarum, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 81(11), 2052-2058, 2013
    Link to Paper Search Results by DOI
  23. ★, Reduction of serum lipids by the intake of the extract of garlic fermented with Monascus pilosus: A randomized, double-blind, placebo-controlled clinical trial, CLINICAL NUTRITION, 31(2), 261-266, 2012
    Link to Paper Search Results by DOI
  24. A Molecular Mechanism for Copper Transportation to Tyrosinase That Is Assisted by a Metallochaperone, Caddie Protein, JOURNAL OF BIOLOGICAL CHEMISTRY, 286(34), 30219-30231, 2011
    Link to Paper Search Results by DOI
  25. Establishment of an in Vitro Peyer's Patch Cell Culture System Correlative to in Vivo Study Using Intestine and Screening of Lactic Acid Bacteria Enhancing Intestinal Immunity, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(2), 289-293, 2010
    Link to Paper Search Results by DOI
  26. ★, Polymeric Osteopontin Employs Integrin alpha 9 beta 1 as a Receptor and Attracts Neutrophils by Presenting a de Novo Binding Site, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(22), 14769-14776, 2009
    Link to Paper Search Results by DOI
  27. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 142(4), 329-334, 2007
    Link to Paper Search Results by DOI
  28. The integrin α5β1 regulates chondrocyte hypertrophic differentiation induced by GTP-bound transglutaminase 2., Matrix Biol, 26(6), 409-418, 2007
    Link to Paper Search Results by DOI
  29. ★, Enhanced biological activity of polymeric osteopontin., FEBS Lett, 581(14), 2697-2701, 2007
    Link to Paper Search Results by DOI
  30. Distinct structural requirements for binding of the integrins alpha v beta 6, alpha v beta 3, alpha v beta 5, alpha 5 beta 1 and alpha 9 beta 1 to osteopontin, MATRIX BIOLOGY, 24(6), 418-427, 2005
    Link to Paper Search Results by DOI
  31. Association of Single Nucleotide Polymorphisms in the Eosinophil Peroxidase Gene with Japanese Cedar Pollinosis., International Archives of Allergy and Immuhology, 135(1), 40-43, 2004
  32. ★, Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats., Journal of Pharmacy and Pharmacology, 51(1), 67-72, 1999
    Link to Paper Search Results by DOI
  33. ★, In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats., Journal of Pharmacy and Pharmacology, 51(4), 405-410, 1999
    Link to Paper Search Results by DOI
  34. Hapatic Metabolic Clearance of Midazolam, a Cytochrome P450 3A Substrate, in the presence of ketoconazole in rats., Pharm. Pharmacol. Commun., 5, 529-536, 1999
  35. Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver., Journal of Pharmacy and Pharmacology, 50(4), 425-430, 1998
    Link to Paper Search Results by DOI
  36. First-pass metabolism of ONO-5046 (N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino]benzoyl]aminoacetic acid), a novel elastase inhibitor, in rats., Biological & Pharmaceutical Bulletin, 20(4), 392-396, 1997
    Link to Paper Search Results by DOI
  37. An alternative allosteric regulation mechanism of an acidophilic L-lactate dehydrogenase from Enterococcus mundtii 15-1A, FEBS OPEN BIO, 4, 834-847, 2014
    Link to Paper Search Results by DOI
  38. Hyperlipidemia: complex pathophysiology caused by multiple genetic and environmental factors--in considering the approaches to preventive medicine, Nippon Eiseigaku Zasshi, 60(4), 426-441, 200511
  39. Osteopontin receptors and signal transduction., Nippon Rinsho, 63, 613-617, 200510

Invited Lecture, Oral Presentation, Poster Presentation

  1. Improvement of constipation and liver function by plant-derived lactic acid bacteria: Probiotic effects of Lactobacillus plantarum, Kazuhiro Nomura, Fumiko Higashikawa, Masanori Sugiyama, Contribution of Lactic acid Bacteria to Preventive and Pre-symptomatic Medicine, 2009/12, With Invitation, English, South Korea
  2. A plant-derived lactic acid bacterium prevents metabolic syndrome, Fumiko Higashikawa, Contribution of Lactic Acid Bacteria to Preventive and Pre-symptomatic Medicines, 2009/03, With Invitation, Japanese, Hiroshima, Japan
  3. Polymeric osteopontin employs integrin α9β1 as a receptor and attracts neutrophils by presenting a de novo binding site, Yasuyuki Yokosaki, Norihisa Nishimichi, Fumiko Higashikawa, H. Hiromi Kinoh, Yoshiko Tateishi, Haruo Matsuda, 2009/10, Without Invitation, Kobe, Japan
  4. Development of an in vitro Method Using the Peyer's Patch for Screening of Lactic Acid Bacteria that Display Excellent Probiotic., Zhao X, Jin H, Higashikawa F, Noda M, Park SN, Sugiyama M, International Meeting of the Federation of Korean Microbiological Societies, 2008, 2008/10, Without Invitation, English
  5. Polymerization of osteopontin enhances its biological activity., Yasuyuki Yokosaki, Kinoh HH, Higashikawa F, Gordon conference, Small integrin Binding-Proteins, 2007/08, Without Invitation, English, Biddeford, ME, USA
  6. Polymeric Osteopontin is a Potent Chemoattractant for Neutrophils Mediated by Integrins., Yasuyuki Yokosaki, Higashikawa F, Gordon conference, Fibronectin, Integrins & Related molecules, 2007/04, Without Invitation, English, Lucca, Italy
  7. Polymorphisms in the integrin super gene family associated with obesity and type 2 diabetes in Japanese American and Japanese population., Tomokazu Awaya, Yasuyuki Yokosaki, Fumiko Higashikawa, Kiminori Yamane, Nobuoki Kono, Akira Eboshida, The 56th Annual Meeting of The American Society of Human Genetics, 2006/10, Without Invitation, English, New Orleans
  8. Transglutaminase 2-catalyzed polymerization activates osteopontin., Fumiko Higashikawa, Yasuyuki Yokosaki, Akira Eboshida, 20th IUBMB International Congress of Biochemistry and Molecular Biology　and 11th FAOBMB Congress, 2006/06, Without Invitation, English, Kyoto, Japan
  9. Association of CCR2 and CCR3 polymorphisms with Japanese cider pollinosis., Hiroyuki Nakamura, Fumiko Higashikawa, Tomohiko Endo, Yoshitaka Nobukuni, Akira Eboshida., American Academy of Allergy, Asthma & Immunology 60th Annual Meeting, 2004/05, Without Invitation, English, San Francisco, CA
  10. Effect of salicylamide on the intestinal first-pass metabolism of acetaminophen in rats., Fumiko Higashikawa, Hajime Ishida, Mineko Fujimoto, Teruo Murakami, Yutaka Higashi, Noboru Yata, The Seventh Japanese-American Conference on Pharmacokinetics and Biophamaceutics, 1994/07, Without Invitation, English, Hiroshima, Japan
  11. Suppression of both the fasting and postprandial plasma glucose levels by 5-aminolevulinic acid, Tohru Tanaka, Fumiko Higashikawa, Masanori Sugiyama, Moto Nakajima, The 7th World Congress of Prevention of Diabetes and its Complication, 2012, Without Invitation, English, Madrid, Spain
  12. Establishment of an efficient fermentation system of gamma-aminobutylic acid by a carrot-leaf-derived lactic acid bacterium Enterococcus avium G-15., Masafumi Noda, Tamura, T., Ogura, S., Oda, K., Higashikawa, F., Matoba, Y., Kumagai, T., and Sugiyama, M, IUMS2011, 2011, Without Invitation, English, Sapporo, Japan
  13. Kinetic and structural analyses of two L-lactate dehydrogenases from Enterococcus mundtii 15-1A., Miyasako, M, Matoba, Y., Noda, M., Higashikawa, F., Kumagai, T., and Sugiyama, M., IUMS2011, 2011, Without Invitation, English, Sapporo, Japan
  14. Biosynthesis of sulfur-containing amino acids in Lactobacillus plantarum SN35N., Kihara H, Matoba, Y., Kumagai, T., Noda, M., Higashikawa, F., and Sugiyama, M., IUMS2011, 2011, Without Invitation, English, Sapporo, Japan

Awards

  1. 2011/09/04, The 14th John M. Kinney Award for General Nutrition, The Nutritional Sciences,Education & Research Fund (NSERF) と国際栄養科学雑誌「Nutrition」との連名

Social Activities

History as Peer Reviews of Academic Papers

  1. 2026, Scientific Reports, Others, reviewer, 1
  2. 2025, Probiotics and Antimicrobial Proteins, Others, reviewer, 1
  3. 2025, Photodiagnosis and Photodynamic Therapy, Others, reviewer, 1
  4. 2024, Scientific Reports, Others, reviewer, 2
  5. 2019, Clinical Nutrition, Others, reviewer, 1
  6. 2019, Bulletins of the Pharmaceutical Society of Japan, Others, reviewer, 1
  7. 2015, In Vitro Cellular & Developmental Biology, Others, reviewer, 1
  8. 2015, Clinical Nutrition, Others, reviewer, 1
  9. 2014, Integrated Blood Pressure Control, Others, reviewer, 1
  10. 2013, Clinical Nutrition, Others, reviewer, 1
  11. 2012, European Journal of Nutrition, Others, reviewer, 1
  12. 2012, Clinical Nutrition, Others, reviewer, 1
  13. 2011, Cholesterol, Others, reviewer, 1