HIROYUKI KAMIYA
Last Updated :2025/02/04
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
- E-mail
- hirokam
hiroshima-u.ac.jp
- Self-introduction
- I am interested in nucleic acids including DNA, the blueprint of life, and study "molecular mechanisms of mutagenesis and carcinogenesis by DNA damage" and "design of DNAs for genome editing" as the main projects.
Basic Information
Academic Degrees
- Doctor of Philosophy in Pharmaceutical Science, HOKKAIDO UNIVERSITY
Educational Activity
- [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
- [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences
In Charge of Primary Major Programs
- Pharmaceutical Sciences
- Medicinal Sciences
Research Fields
- Medicine,dentistry, and pharmacy;Pharmacy;Biological pharmacy
- Environmental science;Environmental analyses and evaluation;Risk sciences of radiation and chemicals
- Medicine,dentistry, and pharmacy;Pharmacy;Medical pharmacy
Research Keywords
- DNA damage, DNA repair, genome editing, gene correction
Educational Activity
Course in Charge
- 2024, Undergraduate Education, 4Term, Pharmaceutical Analysis
- 2024, Undergraduate Education, Intensive, Pharmaceutical Analysis
- 2024, Undergraduate Education, 2Term, Bio-Analytical Science
- 2024, Undergraduate Education, First Semester, Research Practice A
- 2024, Undergraduate Education, Second Semester, Research Practice B
- 2024, Undergraduate Education, First Semester, Practice of Analytical Drug Discovery and Evaluation
- 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
- 2024, Undergraduate Education, Second Semester, Experiments in Analytical Chemistry
- 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
- 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
- 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
- 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
- 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
- 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Nucleic Acids Biochemistry
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Nucleic Acids Biochemistry
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Nucleic Acids Biochemistry
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Nucleic Acids Biochemistry
- 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
- 2024, Graduate Education (Master's Program) , First Semester, Lecture on Nucleic Acids Biochemistry
- 2024, Graduate Education (Master's Program) , First Semester, Seminar on Nucleic Acids Biochemistry
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Nucleic Acids Biochemistry
- 2024, Graduate Education (Master's Program) , First Semester, Research on Nucleic Acids Biochemistry
- 2024, Graduate Education (Master's Program) , Second Semester, Research on Nucleic Acids Biochemistry
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Nucleic Acids Biochemistry for Medicinal Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Nucleic Acids Biochemistry for Medicinal Sciences
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Nucleic Acids Biochemistry for Medicinal Sciences
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Nucleic Acids Biochemistry for Medicinal Sciences
Research Activities
Academic Papers
- Correction of substitution, deletion, and insertion mutations by 5'-tailed duplexes, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 137(3), 157-164, 202403
- Action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine are dependent on APOBEC3, MUTAGENESIS, 39(1), 24-31, 20240208
- Easily-controllable, helper phage-free single-stranded phagemid production system, GENES AND ENVIRONMENT, 44(1), 20221116
- Correction of monomeric enhanced green fluorescent protein (mEGFP) gene by short 5'-tailed duplexes, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 134(3), 175-181, 202209
- Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli, ELIFE, 11, 20221010
- Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 825, 2022
- ★, Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine, DNA REPAIR, 111, 202203
- Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions, JOURNAL OF TOXICOLOGICAL SCIENCES, 46(6), 283-288, 202106
- Action-at-a-distance mutations at 5 '-GpA-3 ' sites induced by oxidised guanine in WRN-knockdown cells, MUTAGENESIS, 36(5), 349-357, 202109
- Gene correction by 5 '-tailed duplexes with short editor oligodeoxyribonucleotides, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 132(6), 552-559, 202112
- Conventional plasmid DNAs with a CpG-containing backbone achieve durable transgene expression in mouse liver, JOURNAL OF GENE MEDICINE, 22(1), e3138, 202001
- Single-stranded DNA versus tailed duplex in sequence conversion of lacZalpha DNA, Nucleosides Nucleotides Nucleic Acids, 39(9), 1245-1250, 202009
- New indicator Escherichia coli strain for rapid and accurate detection of supF mutations, GENES AND ENVIRONMENT, 42(1), 28, 20200922
- Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells, PLOS ONE, 15(12), e0244790, 20201231
- High-throughput analysis of DNA repair in microplates towards identification of inhibitors, GENES AND ENVIRONMENT, 42(1), 11, 20200309
- No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 38(12), 942-949, 20191202
- Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells, MUTAGENESIS, 34(5-6), 421-429, 2019
- Reduction of Werner Syndrome Protein Enhances G:C -> A:T Transition byO(6)-Methylguanine in Human Cells, CHEMICAL RESEARCH IN TOXICOLOGY, 31(5), 319-324, 201805
- Effects of mismatches distant from the target position on gene correction with a 5 '-tailed duplex, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 125(5), 619-623, 201805
- Durable Transgene Expression Driven by CpG-Free and -Containing Promoters in Plasmid DNA with CpG-Free Backbone, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41(9), 1489-1493, 201809
- Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase lambda-double knockdown cells, MUTAGENESIS, 33(4), 301-310, 201807
- Analysis of large deletion mutations induced by abasic site analog in human cells, GENES AND ENVIRONMENT, 40, 20181024
- Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 123(3), 277-280, 201703
- Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 36(6), 428-434, 2017
- Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells., Genes Environment, 39, 2 (6 pages), 201701
- In vivo selection of active deoxyribonucleoside kinase by a mutagenic nucleoside analog, JOURNAL OF BIOTECHNOLOGY, 228, 52-57, 20160620
- Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 35(7), 379-388, 2016
- Cleavage of Target DNA Promotes Sequence Conversion with a Tailed Duplex, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39(8), 1392-1395, 201608
- Life Style and Cancer - The Open Symposium of the Japanese Environmental Mutagen Society (JEMS) in 2015, GENES AND ENVIRONMENT, 38, 2016
- Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells, CHEMICAL RESEARCH IN TOXICOLOGY, 28(4), 621-628, 201504
- Transcription of 4 '-thioDNA templates to natural RNA in vitro and in mammalian cells, CHEMICAL COMMUNICATIONS, 51(37), 7887-7890, 2015
- Induction of action-at-a-distance mutagenesis by 8-oxo-7,8-dihydroguanine in DNA pol lambda-knockdown cells, GENES AND ENVIRONMENT, 37, 2015
- Anatomy of plasmid DNAs with anti-silencing elements, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 464(1-2), 27-33, 2014
- Suppression of short tract gene conversion in episomal DNA by p53 reduction, Genes Environment, 36(2), 65-68, 2014
- In vitro Replication Study of Modified bases in ras Sequences., Pharmaceutical Bulletin, 40(10), 2792-2795, 1992
- Mutagenicities of 8-Hydroxyguanine and 2-Hydroxyadenine Produced by Reactive Oxygen Species (Biological and Pharmaceutical Aspects of Nucleic Acids Chemistry), Biological & pharmaceutical bulletin, 27(4), 475-479, 20040401
- Pharmacokinetic Modeling of Species-dependent Enhanced Bioavailability of Trifluorothymidine by Thymidine Phosphorylase Inhibitor, Drug Metabolism and Pharmacokinetics, 19(3), 206-215, 2004
- Calpain 10 as a Predictive Gene for Type 2 Diabetes : Evidence from a Novel Screening System Using White Blood Cells of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats (Biopharmacy), Biological & pharmaceutical bulletin, 26(12), 1765-1768, 20031201
- Mutagenicity of 5-Formylcytosine, an Oxidation Product of 5-Methylcytosine, in DNA in Mammalian Cells, Journal of Biochemistry, 132(4), 551-555, 20021001
- 2-Hydroxyadenine in DNA is a Very Poor Substrate of the Escherichia coli MutY Protein, Journal of radiation research, 41(4), 349-354, 200012
- Comparison of Oxidation Products from DNA Components by gamma-Irradiation and Fenton-Type Reactions, Journal of radiation research, 38(2), 121-131, 199706
- Comparison of Incorporation and Extension of Nucleotides in vitro opposite 8-Hydroxyguanine (7,8-Dihydro-8-oxoguanine) in Hot Spots of the c-Ha-ras Gene, Jpn. J. Cancer Res., 86(3), 270-276, 19950331
- Inhibition of c-Ha-ras Gene Expression by Hammerhead Ribozymes Containing a Stable C(UUCG)G Hairpin Loop, Biological & pharmaceutical bulletin, 16(9), 879-883, 19930915
- Overproduction of cellular and activated Ha-ras proteins by mutating a synthetic gene., Pharmaceutical Bulletin, 35(12), 4878-4882, 1987
- Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 36(12), 2009-2011, 2013
- Correlation between transgen expression and plasmid DNA loss in mouse liver, JOURNAL OF GENE MEDICINE, 15(6-7), 242-248, 2013
- Enhanced transgene expression from chromatinized plasmid DNA in mouse liver, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 441(1-2), 146-150, 2013
- Effects of Endogenous Proteins and microRNA Target Sequence in a Positive Feedback System, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(9), 1534-1538, 2012
- Mutagenic Bypass of 8-Oxo-7,8-dihydroguanine (8-Hydroxyguanine) by DNA Polymerase kappa in Human Cells, CHEMICAL RESEARCH IN TOXICOLOGY, 25(8), 1771-1776, 2012
- Insights into substrate recognition by the Escherichia coli Orf135 protein through its solution structure, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 420(2), 263-268, 2012
- H-1, C-13 and N-15 NMR assignments of the Escherichia coli Orf135 protein, BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 1-4, 2012
- CREB-binding protein transcription activation domain for enhanced transgene expression by a positive feedback system, JOURNAL OF BIOTECHNOLOGY, 157(1), 7-11, 2012
- Diverse substrate recognition and hydrolysis mechanisms of human NUDT5, NUCLEIC ACIDS RESEARCH, 39(20), 8972-8983, 2011
- Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 112(5), 432-434, 2011
- Correction of Frameshift Mutations with Tailed Duplex DNAs, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(9), 1465-1468, 2011
- Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2 '-deoxyguanosine 5 '-triphosphate (8-hydroxy-2 '- deoxyguanosine 5 '-triphosphate), MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 714(1-2), 11-16, 2011
- Mutagenicity of oxidized DNA precursors in living cells: Roles of nucleotide pool sanitization and DNA repair enzymes, and translesion synthesis DNA polymerases, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 703(1), 32-36, 2010
- ★, Positive Feedback System Provides Efficient and Persistent Transgene Expression, MOLECULAR PHARMACEUTICS, 7(4), 1125-1132, 2010
- Cytotoxic Effect of Drosophila Deoxynucleoside Kinase Gene on Replicating Plasmid in HeLa Cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(7), 1223-1227, 2010
- Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 392(1-2), 249-253, 2010
- DNA Microarray Analysis of Whole Blood Cells and Insulin-Sensitive Tissues Reveals the Usefulness of Blood RNA Profiling as a Source of Markers for Predicting Type 2 Diabetes, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33(6), 1033-1042, 2010
- ★, Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine, DNA REPAIR, 9(5), 542-550, 2010
- Suppression of mutagenesis by 8-hydroxy-2 '-deoxyguanosine 5 '-triphosphate (7,8-dihydro-8-oxo-2 '-deoxyguanosine 5 '-triphosphate) by human MTH1, MTH2, and NUDT5, FREE RADICAL BIOLOGY AND MEDICINE, 48(9), 1197-1201, 2010
- Roles of specialized DNA polymerases in mutagenesis by 8-hydroxyguanine in human cells, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 686(1-2), 90-95, 2010
- ★, Targeted sequence alteration of a chromosomal locus in mouse liver, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 387(1-2), 180-183, 2010
- NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity, DNA REPAIR, 8(10), 1250-1254, 2009
- PK-PD modeling of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 377(1-2), 52-59, 2009
- Effects of carriers on transgene expression from plasmids containing a DNA sequence with high histone affinity, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 376(1-2), 99-103, 2009
- Effects of non-B DNA sequences on transgene expression, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 108(1), 18-21, 2009
- Incorporation of 8-hydroxyguanosine (8-oxo-7,8-dihydroguanosine) 5'-triphosphate by bacterial and human RNA polymerases, FREE RADICAL BIOLOGY AND MEDICINE, 46(12), 1703-1707, 2009
- Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells, DNA REPAIR, 8(5), 637-642, 2009
- Effects of target sequence and sense versus anti-sense strands on gene correction with single-stranded DNA fragments, JOURNAL OF BIOCHEMISTRY, 144(4), 431-436, 2008
- ★, Improved gene correction efficiency with a tailed duplex DNA fragment, BIOCHEMISTRY, 47(33), 8754-8759, 2008
- Specificity of mutations induced by incorporation of oxidized dNTPs into DNA by human DNA polymerase eta, DNA REPAIR, 7(3), 497-506, 2008
- MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1778(2), 423-432, 2008
- Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP, DNA REPAIR, 7(1), 88-94, 2008
- UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides, DNA REPAIR, 6(12), 1786-1793, 2007
- Effects of 8-hydroxy-GTP and 2-hydroxy-ATP on in vitro transcription, FREE RADICAL BIOLOGY AND MEDICINE, 43(5), 837-843, 2007
- 2-hydroxy-2 '-deoxyadenosine 5 '-triphosphate enhances A center dot T -> C center dot G mutations caused by 8-hydroxy-2 '-deoxyguanosine 5 '-triphosphate by suppressing its degradation upon replication in a HeLa extract, BIOCHEMISTRY, 46(22), 6639-6646, 2007
- ★, Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells, FREE RADICAL BIOLOGY AND MEDICINE, 42(10), 1552-1560, 2007
- Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta, BIOCHEMISTRY, 46(18), 5515-5522, 2007
- The location of the left-handedly curved DNA sequence affects exogenous DNA expression in vivo, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 461(1), 7-12, 2007
- DNA microarray analysis of type 2 diabetes-related genes co-regulated between white blood cells and livers of diabetic Otsuka long-evans Tokushima fatty (OLETF) rats, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 30(4), 763-771, 2007
- Induction of various mutations during PCRs with manganese and 8-hydroxy-dGTP, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 30(4), 842-844, 2007
- Cell cycle dependent transcription, a determinant factor of heterogeneity in cationic tipid-mediated transgene expression, JOURNAL OF GENE MEDICINE, 9(3), 197-207, 2007
- Mitochondrial drug delivery and mitochondrial disease therapy - An approach to liposome-based delivery targeted to mitochondria, MITOCHONDRION, 7(1-2), 63-71, 2007
- Development of multifunctional envelope type artificial viral like gene delivery system, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127(10), 1655-1672, 2007
- Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein, JOURNAL OF BIOCHEMISTRY, 140(6), 843-849, 2006
- Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 62, 1283-1285, 2006
- Silencing of exogenous DNA in cultured cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 29(6), 1294-1296, 2006
- Effects of overexpression and antisense RNA expression of Orf17, a MutT-type enzyme, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 29(6), 1087-1091, 2006
- DNA polymerase λ promotes mutagenesis induced by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with adenine, Genes Environment, 35(4), 105-109, 2013
- A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver, Gene Ther., 19(8), 828-835, 2012
- Human MTH3 (NUDT18) with a distinct enzyme activity cleaving oxidized forms of dGDP and GDP: A comparison with MTH1 and MTH2, J. Biol. Chem., 287(25), 21541-21549, 2012
- Unexpectedly weak impacts of decreased p53 and retinoblastoma protein levels on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine), Genes Environment, 33(3), 103-108, 2011
- ★, Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression, Gene Therapy, 14(15), 1152-1159, 2007
- ★, Increased SFHR gene correction efficiency with sense single-stranded DNA, J. Gene Med., 7(4), 486-493, 2005
- ★, Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs, J. Mol. Biol., 336(4), 843-850, 2004
- ★, Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: Approaches using synthetic oligonucleotides and nucleotides, Nucleic Acids Res., 31(2), 517-531, 2003
- Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA, Nucleic Acids Res., 29(16), 3433-3438, 2001
- ★, The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein, J. Biol. Chem., 274(26), 18201-18205, 1999
- ★, Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides, J. Biol. Chem., 273(18), 11069-11074, 1998
- ★, Mutations induced by 2-hydroxyadenine on a shuttle vector during leading and lagging strand syntheses in mammalian cells, Biochemistry, 36(37), 11125-11130, 1997
- ★, Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases, J. Biol. Chem., 270(33), 19446-19450, 1995
- 8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Effects of sequence contexts on mutation spectra, Carcinogenesis, 16(4), 883-889, 1995
- ★, c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions, Cancer Res., 52(12), 3483-3485, 1992
- Cyclobutane thymine-photodimers in a ras protooncogene hot spot activate the gene by point mutation, Nucleic Acids Res., 21(10), 2355-2361, 1993
- Mutations induced by oxidized DNA precursors and their prevention by nucleotide pool sanitization enzymes, Genes Environment, 29(4), 133-140, 200711
- Correlation between the phosphohydrolase activity of the Escherichia coli Orf135 (NudG) protein and mutation suppression, Genes Environment, 29(2), 63-66, 200705
- Increased A:T→C:G Mutations in the mutT Strain upon 8-Hydroxy-dGTP Treatment : Direct Evidence for MutT Involvement in the Prevention of Mutations by Oxidized dGTP, Journal of Biochemistry, 136(3), 359-362, 20040901
- Induction of Transition and Transversion Mutations during Random Mutagenesis PCR by the Addition of 2-Hydroxy-dATP (Biochemistry/Molecular Biology), Biological & pharmaceutical bulletin, 27(5), 621-623, 20040501
- In Vivo Mutagenicities of Damaged Nucleotides Produced by Nitric Oxide and Ionizing Radiation(Biochemistry/Molecular Biology), Biological & pharmaceutical bulletin, 28(3), 520-522, 20050301
- Effect of Methylated Adenine in Plasmid DNA on Transgene Expression in Mice(Biopharmacy), Biological & pharmaceutical bulletin, 28(10), 2019-2022, 20051001
- Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract, Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 28(3), 92-96, 20060831
- Silencing of Exogenous DNA in Cultured Cells(Biopharmacy), Biological & pharmaceutical bulletin, 29(6), 1294-1296, 20060601
- New NTP analogs: the synthesis of 4'-thioUTP and 4'-thioCTP and their utility for SELEX, Nucleic Acids Research, 33(9), 2942-2951, 200505
- RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells, FEBS Letters, 579(14), 3115-3118, 20050606
Publications such as books
- 2005/08, Modern biopharmaceuticals, Programmed packaging: A new drug delivery system and its application to gene therapy, Wiley-VCH, 2005, 08, Scholarly Book, Joint work, English, K. Kogure, H. Akita, H. Kamiya, and H. Harashima
- 2005, Non-viral Gene Therapy: Gene Design and Delivery, Newly designed DNA fragments for gene correction, Springer-Verlag Tokyo, 2005, Scholarly Book, Joint work, English, H. Kamiya, H. Tsuchiya, and H. Harashima
Invited Lecture, Oral Presentation, Poster Presentation
- Abasic site analog in lagging strand template induces mutations more frequently than that in leading strand template, T. Suzuki, Y. Katayama, H. Kamiya, 6th Asian Congress on Environmental Mutagens, 2019/11/18, Without Invitation, English, Asian Association of Environmental Mutagen Societies, Tokyo
- OGG1-knockdown increases large deletions but decreases untargeted substitutions induced by 8-oxo-7,8-dihydroguanine, Y. Zaima, T. Suzuki, H. Kamiya, 6th Asian Congress on Environmental Mutagens, 2019/11/18, Without Invitation, English, Asian Association of Environmental Mutagen Societies, Tokyo
- The role of P53 oscillations via MDM2-MDMX in DNA damage-induced cell fate decisions, H. Kawai, H. Kamiya, 6th Asian Congress on Environmental Mutagens, 2019/11/18, Without Invitation, English, Asian Association of Environmental Mutagen Societies, Tokyo
- Large deletion mutations induced by an abasic site analogue in human cells, H. Kamiya, Y. Katayama, T. Suzuki, and Y. Komatsu, 12th International Conference and 5th Asian Congress on Environmental Mutagens, 2017/11/13, Without Invitation, English, Asian Association of Environmental Mutagen Societies, Incheon, Korea
- Cleavage of target DNA promotes sequence conversion with a tailed duplex., H. Kamiya, T. Suzuki, T. Imada, N. Nishigaki, M. Kobayashi, I. Matsuoka, The 43rd International Symposium on Nucleic Acids Chemistry, 2016/09/28, Without Invitation, English, Kumamoto
Patented
- Patent, CA 2551696, 2014/05/27, Immunopotentiator and method of enhancing immunological activity using the same
- Patent, EP 1702620, 2014/01/08, Immunopotentiator and method of enhancing immunological activity with the same
- Patent, CA 2555489, 2012/05/08, Method of converting base in DNA sequence
External Funds
Acceptance Results of Competitive Funds
- KAKENHI(Grant-in-Aid for Scientific Research (B)), 2019, 2021
- KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2017, 2019
- KAKENHI, 2016, 2018
Social Activities
History as Committee Members
- Editorial Board, 2012/01, 2024/12