NOBUAKI SHIME

Last Updated :2022/08/04

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
nshimehiroshima-u.ac.jp
Self-introduction
Emergency and Critical Care Medicine

Basic Information

Major Professional Backgrounds

  • 2020, Kyoto Prefectural University of Medicine, Visiting Professor
  • 2020, Doshisha University, Visiting Professor

Academic Degrees

  • Kyoto Prefectural University of Medicine

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Emergency medicine

Research Keywords

  • sepsis, antibiotics, pneumonia, ECMO, ARDS

Affiliated Academic Societies

  • Japanese Society of Intensive Care Medicine
  • Japanese Association of Acute Medicine
  • Japanese Society of Infectious Disease
  • Japanese Society of Antimicrobial and Chemotherapy

Educational Activity

Course in Charge

  1. 2022, Graduate Education (Doctoral Program) , 2Term, Multidisciplinary Cooperation B
  2. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Emergency and Critical Care Medicine
  3. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Emergency and Critical Care Medicine
  4. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Emergency and Critical Care Medicine
  5. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Emergency and Critical Care Medicine
  6. 2022, Undergraduate Education, Year, Systemic Disease Control
  7. 2022, Undergraduate Education, Intensive, Practice for medical research
  8. 2022, Undergraduate Education, Intensive, Practice of Medicine I
  9. 2022, Undergraduate Education, Intensive, Practice of Medicine II
  10. 2022, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  11. 2022, Undergraduate Education, Second Semester, Emergency and Critical Care Medicine
  12. 2022, Graduate Education (Master's Program) , 2Term, Multidisciplinary Cooperation A

Research Activities

Academic Papers

  1. Respiratory rate criteria for pediatric systematic inlammatory response syndrome, Pediatr Crit Care Med, 15(2), 182-182, 2014
  2. A novel method for ultrasound-guided radial arterial catheterization in pediatric patients, Anesth Analg, 118(5), 1019-1026, 2014
  3. Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome, BMJ Case Rep, 2014
  4. A pilot study of Bifidobacterium breve in neonates undergoing surgery for congenital heart disease, Journal of Intensive Care, 2(36), 2014
  5. Sepsis Registry Committee of The Japanese Society of intensive Care Medicine, Journal of Intensive Care, 2(55), 2014
  6. ★, Early mobilization of mechanically ventilated patients in the intensive care unit, JOURNAL OF INTENSIVE CARE, 4, 20160729
  7. Pediatric cardiorespiratory failure successfully managed with venoarterial-venous extracorporeal membrane oxygenation: a case report, BMC PULMONARY MEDICINE, 16, 20160812
  8. A survey of the competency of ambulance service personnel in the diagnosis and management of sepsis., J Emerg Med, 49(2), 147-151, 2015
  9. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study., Am J Respir Crit Care Med., 191(10), 1147-1157, 20150515
  10. Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study., Crit Care., 19, 325-325, 2015
  11. Ultrasound Imaging Reduces Failure Rates of Percutaneous Central Venous Catheterization in Children., Pediatr Crit Care Med., 16(8), 718-725, 2015
  12. Innovation, Cost, and Sustainability of Pediatric Ventricular Assist Device Programs., Pediatr Crit Care Med., 16(6), 589-590, 201507
  13. Polymyxin B haemoperfusion in septic shock patients., Intensive Care Med., 41(11), 2033-2033, 2015
  14. Clinical and investigative critical care medicine in Japan., Intensive Care Med., 42(3), 453-455, 201603
  15. Emphysematous pancreatitis., Intensive Care Med., 42(6), 1075-1075, 2016
  16. Exploring Causative Pathology Is Essential for Validating Harmful Effects of Late Intubation., Crit Care Med, 44, e770-e771, 2016
  17. Current rehabilitation practices in intensive care units: a preliminary survey by the Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group., J Intensive Care., 28(4), 66-66, 201610
  18. Is transpulmonary pressure-guided PEEP titration really optimal?, Intensive Care Med., 42(11), 1845-1846, 201611
  19. Exploring Potential Cofactors Affecting Coagulation and Inflammation Activity During Extracorporeal Membrane Oxygenation., Crit Care Med., 44(11), e1149-e1150, 201611
  20. Potential covariates that affect post-extubation breathing effort in children., Intensive Care Med., 42(12), 2127-2128, 201612
  21. Is an Earlier and More Intensive Physical Therapy Program Better?, Am J Respir Crit Care Med., 194(8), 1032-1032, 201610
  22. Are probiotics actually useful in decreasing VAP rate?, Intensive Care Med., 42(10), 1643-1644, 201610
  23. Factors affecting biomarkers of endothelial andalveolar epithelial dysfunction., Intensive Care Med., 42(12), 2111-2112, 201612
  24. Successful treatment of traumatic spinal epidural haematoma with fluoroscopically-guided percutaneous drainage: a report of two cases, ANAESTHESIA AND INTENSIVE CARE, 44(6), 777-780, 201611
  25. Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis, SCIENTIFIC REPORTS, 6, 2016
  26. Early mobilization of mechanically ventilated patients in the intensive care unit., J Intensive Care, 29(4), 50-50, 2016
  27. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, 2017
  28. Pneumonia Severity Assessment Tools for Predicting Mortality in Patients with Healthcare-Associated Pneumonia: A Systematic Review and Meta-Analysis, RESPIRATION, 93(6), 441-450, 2017
  29. Clinical and investigative critical care medicine in Japan, INTENSIVE CARE MEDICINE, 42(3), 453-455, 2016
  30. Emphysematous pancreatitis, INTENSIVE CARE MEDICINE, 42(6), 1075-1075, 2016
  31. Exploring Causative Pathology Is Essential for Validating Harmful Effects of Late Intubation, CRITICAL CARE MEDICINE, 44(8), E770-E771, 2016
  32. Are probiotics actually useful in decreasing VAP rate?, INTENSIVE CARE MEDICINE, 42(10), 1643-1644, 2016
  33. Is an Earlier and More Intensive Physical Therapy Program Better?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 194(8), 1032-1032, 2016
  34. Is transpulmonary pressure-guided PEEP titration really optimal?, INTENSIVE CARE MEDICINE, 42(11), 1845-1846, 2016
  35. Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction, INTENSIVE CARE MEDICINE, 42(12), 2111-2112, 2016
  36. Potential covariates that affect post-extubation breathing effort in children, INTENSIVE CARE MEDICINE, 42(12), 2127-2128, 2016
  37. Proposal of a New Pediatric Sequential Organ Failure Assessment Score for Possible Validation, PEDIATRIC CRITICAL CARE MEDICINE, 18(1), 98-99, 2017
  38. Exploring Potential Cofactors Affecting Coagulation and Inflammation Activity During Extracorporeal Membrane Oxygenation, CRITICAL CARE MEDICINE, 44(11), E1149-E1150, 2016
  39. Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 196(6), 795-796, 2017
  40. Current rehabilitation practices in intensive care units: a preliminary survey by the Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group., J Intensive Care., 4(66), 2016
  41. Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis., Sci Rep., 6(38097), 20161207
  42. Repetitive postoperative extubation failure and cardiac arrest due to laryngomalacia after general anesthesia in an elderly patient: a case report, JOURNAL OF ANESTHESIA, 31(5), 779-781, 201710
  43. Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study, CRITICAL CARE, 21, 20171221
  44. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), ACUTE MEDICINE & SURGERY, 5(1), 3-89, 201801
  45. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), JOURNAL OF INTENSIVE CARE, 6, 20180202
  46. ★, Association between appropriate empiric antimicrobial therapy and mortality from bloodstream infections in the intensive care unit, JOURNAL OF INFECTION AND CHEMOTHERAPY, 24(4), 267-271, 201804
  47. Combined short- and long-axis ultrasound-guided central venous catheterization is superior to conventional techniques: A cross-over randomized controlled manikin trial, PLOS ONE, 12(12), 20171207
  48. Successful anesthetic management during abdominal wall-lifting laparoscopic cholecystectomy in a patient with hereditary angioedema, JA CLINICAL REPORTS, 4, 20180509
  49. An outbreak of fluoroquinolone-resistant Pseudomonas aeruginosa ST357 harboring the exoU gene, JOURNAL OF INFECTION AND CHEMOTHERAPY, 24(8), 615-622, 201808
  50. Oxygen management in mechanically ventilated patients: A multicenter prospective observational study, JOURNAL OF CRITICAL CARE, 46, 1-5, 201808
  51. Comparison of extracorporeal membrane oxygenation outcome for influenza-associated acute respiratory failure in Japan between 2009 and 2016, JOURNAL OF INTENSIVE CARE, 6, 20180711
  52. ★, Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway, TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 245(3), 193-204, 201807
  53. ★, Clinical outcomes after initial treatment of methicillin-resistant Staphylococcus aureus infections, INFECTION AND DRUG RESISTANCE, 11, 1073-1081, 2018
  54. A survey on infection control in emergency departments in Japan, ACUTE MEDICINE & SURGERY, 5(4), 374-379, 201810
  55. Out-of-bed mobilization of patients undergoing mechanical ventilation with orotracheal tubes: A survey study, JOURNAL OF CRITICAL CARE, 47, 173-177, 201810
  56. ★, Implementation of an empirical antimicrobial protocol in a critical care setting: A single-center retrospective observational cohort study in bacteremic patients, JOURNAL OF INFECTION AND CHEMOTHERAPY, 24(12), 965-968, 201812
  57. Combined rupture of left ventricular free wall and pericardium, Intensive Care Medicine, 43(12), 1858-1859, 20171201
  58. Does enhanced antibiotic de-escalation really have no benefit in the ICU?, Critical Care, 21(1), 20171102
  59. Risk factors for sepsis-associated encephalopathy, Intensive Care Medicine, 43(10), 1548-1549, 20171001
  60. Is Higher Cerebral Oxygen Saturation Really Predictive of Favorable Neurologic Outcome after In-Hospital Cardiac Arrest?, Critical Care Medicine, 45(4), 468-469, 20170401
  61. Outcome prediction for acute respiratory distress syndrome: Are the current three variables really optimal?, Critical Care Medicine, 45(2), 237-238, 20170201
  62. The role of source control in septic patients, Critical Care Medicine, 45(6), 618-619, 2017
  63. Potential Confounders of the Accuracy and Reliability of Delirium Assessment Tools, Critical Care Medicine, 45(1), 114-114, 20170101
  64. Optimal cutoff value for lung injury prediction score and potential confounders for identifying the risk of developing acute respiratory distress syndrome, Critical Care Medicine, 45(6), 624-625, 2017
  65. Successful long-term extracorporeal membrane oxygenation for invasive pulmonary aspergillosis: A case report, Journal of Medical Case Reports, 11(1), 2017
  66. The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines (second revised edition), Respiratory Investigation, 55(1), 83-92, 20170101
  67. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality, Pediatric Critical Care Medicine, 18(1), 8-16, 20170101
  68. Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia, JOURNAL OF ARTIFICIAL ORGANS, 21(4), 475-478, 201812
  69. Ventilator-associated events: prevalence and mortality in Japan, JOURNAL OF THORACIC DISEASE, 10(12), 6942-6949, 201812
  70. ★, A Therapeutic Strategy for All Pneumonia Patients: A 3-Year Prospective Multicenter Cohort Study Using Risk Factors for Multidrug-resistant Pathogens to Select Initial Empiric Therapy, CLINICAL INFECTIOUS DISEASES, 68(7), 1080-1088, 20190401
  71. Comparing Combined Short-Axis and Long-Axis Ultrasound-Guided Central Venous Catheterization update, With Conventional Short-Axis Out-of-Plane Approaches, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 33(4), 1029-1034, 201904
  72. Comparison of three video laryngoscopes and direct laryngoscopy for emergency endotracheal intubation: a retrospective cohort study, BMJ OPEN, 9(3), 201906
  73. Dynamic Needle Tip Positioning for Ultrasound Guided Arterial Catheterization in Infants and Small Children With Deep Arteries: A Randomized Controlled Trial, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 33(7), 1919-1925, 201907
  74. Potential factors affecting lung inhomogeneity in acute respiratory distress syndrome., Intensive Care Med, 44(1), 125-126, 2018
  75. An emerging frontier in the treatment of acute exacerbation of idiopathic pulmonary fibrosis., Respir Investigation, 97-99, 2018
  76. Accurate quantification of pleural effusion and cofactors affecting weaning failure., Anesthesiology 3, 128, 678-679, 2018
  77. Is Oxygenation Really an Intrinsic Predictive Factor of Mortality in Patients Undergoing Extracorporeal Life Support?, Crit Care Med., 46(2), 181-182, 2018
  78. Regional negative pressure pulmonary edema with pulmonary thromboembolism., Internal Medicine, 57(12), 1805-1806, 20180615
  79. Confounders for interpreting the benefit of a biomarker-based strategy in early discontinuation of empirical antifungal therapy., Intensive Care Med., 44(3), 399-400, 201803
  80. Ultrasound-guided central venous catheter placement in children: what is a really good practice?, Intensive Care Med., 44(4), 546-547, 201804
  81. Target blood pressure for septic and vasodilatory shock: what is optimal?, Intensive Care Medicine, 44(4), 548-549, 201804
  82. Memorable Experiencees of US Longterm Internship, Supported by Phoenix Leader Education Program., Anesthesia and Resuscitation., 53(4), 81-84, 201803
  83. Antimicrobials in the PICU: An Unresolved and Serious Matter., Pediatr Crit Care Med., 19(6), 581-582, 201806
  84. Does Dysphagia After Extubation Really Increase Mortality?, Crit Care Med., 46(7), 726-727, 201807
  85. Conducting trials on corticosteroid dosing for respiratory failure in the last paradise., J Intensive Care., 6, 76-76, 20181120
  86. Focusing on Risk Factors of Cardiac Arrest During Intubation in ICU Again., Crit Care Med., 46(11), 1082-1082, 201811
  87. Should We Abandon Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome?, Am J Respir Crit Care Med, 198(11), 1459-1460, 20181201
  88. The western Japan chaotic rainstorm disaster: a brief report from Hiroshima., J Intensive Care., 6, 82-82, 20181217
  89. Pediatric sequential organ failure assessment score (pSOFA): a plea for the world-wide collaboration for consensus., Intensive Care Med., 44(6), 995-997, 201806
  90. Antimicrobials in the PICU: An Unresolved and Serious Matter., Pediatr Crit Care Med., 19(6), 581-582, 201806
  91. Committee of the Japan ECMO project. Comparison of extracorporeal membrane oxygenation outcome for influenza-associated acute respiratory failure in Japan between 2009 and 2016., J Intensive Care., 11(6), 38-38, 201807
  92. Committee for Infection Control for the Emergency Department, the Japanese Association for Acute Medicine, and the joint working group. A survey on infection control in emergency departments in Japan., Acute Med Surg., 5(4), 374-379, 201807
  93. Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia., J Artif Organs., 21(4), 475-478, 201812
  94. Ventilator-associated events: prevalence and mortality in Japan., J Thorac Dis., 10(12), 6942-6949, 201812
  95. Potential confounders for the effect of high-flow nasal cannula oxygen therapy., Crit Care., 23(1), 17-17, 201901
  96. High serum potassium level is associated with successful electrical cardioversion for new-onset atrial fibrillation in the intensive care unit: A retrospective observational study., Anaesth Intensive Care., 47(1), 52-59, 201901
  97. Combined Approach Versus 2 Conventional Approaches in Ultrasound-Guided Central Venous Catheterization: A Randomized Controlled Trial., J Cardiothorac Vasc Anesth., 20190528
  98. Comparison of three video laryngoscopes and direct laryngoscopy for emergency endotracheal intubation: a retrospective cohort study., BMJ Open., 9(3), 024927-024927, 20190330
  99. ICU staffing models and patient outcomes., J Intensive Care., 7, 24-24, 20190424
  100. Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study., J Chemother., 30, 1-6, 201905
  101. Dynamic Needle Tip Positioning for Ultrasound-Guided Placement of a Peripherally Inserted Central Catheter in Pediatric Patients., J Cardiothorac Vasc Anesth., 20190502
  102. Decreased intracellular histamine concentration and basophil activation in anaphylaxis., Allergol International Available online, 20190624
  103. Superiority of Dynamic Needle Tip Positioning for Ultrasound-Guided Peripheral Venous Catheterization in Patients Younger Than 2 Years Old: A Randomized Controlled Trial., Pediatr Crit Care Med., 20190618
  104. Is lung ultrasonography really useful for diagnosing weaning-induced pulmonary oedema?, Intensive Care Med., 20190606
  105. Dynamic Needle Tip Positioning for Ultrasound-Guided Arterial Catheterization in Infants and Small Children With Deep Arteries: A Randomized Controlled Trial., J Cardiothorac Vasc Anesth., 33(7), 1919-1925, 201907
  106. Comparison of video and conventional laryngoscopes for simulated difficult emergency tracheal intubations in the presence of liquids in the airway, PLOS ONE, 14(7), 20190719
  107. Superiority of Dynamic Needle Tip Positioning for Ultrasound-Guided Peripheral Venous Catheterization in Patients Younger Than 2 Years Old: A Randomized Controlled Trial*, PEDIATRIC CRITICAL CARE MEDICINE, 20(9), e410-e414, 201909
  108. Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome An International Multicenter Prospective Cohort, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(8), 1002-1012, 20191015
  109. High serum potassium level is associated with successful electrical cardioversion for new-onset atrial fibrillation in the intensive care unit: A retrospective observational study, ANAESTHESIA AND INTENSIVE CARE, 47(1), 52-59, 201901
  110. Combined Approach Versus 2 Conventional Approaches in Ultrasound-Guided Central Venous Catheterization: A Randomized Controlled Trial, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 33(11), 2979-2984, 201911
  111. Unique patterns of lower respiratory tract microbiota are associated with inflammation and hospital mortality in acute respiratory distress syndrome, RESPIRATORY RESEARCH, 20(1), 20191106
  112. Ceftolozane-tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase 3, non-inferiority trial, LANCET INFECTIOUS DISEASES, 19(12), 1299-1311, 201912
  113. Retrospective immunohistological study of autopsied lungs in patients with acute exacerbation of interstitial pneumonia managed with extracorporeal membrane oxygenation, JOURNAL OF THORACIC DISEASE, 11(11), 4436-4443, 201911
  114. Decreased intracellular histamine concentration and basophil activation in anaphylaxis, ALLERGOLOGY INTERNATIONAL, 69(1), 78-83, 20200101
  115. Baseline High-Resolution CT Findings Predict Acute Exacerbation of Idiopathic Pulmonary Fibrosis: German and Japanese Cohort Study, JOURNAL OF CLINICAL MEDICINE, 8(12), 201912
  116. Dynamic Needle Tip Positioning for Ultrasound-Guided Placement of a Peripherally Inserted Central Catheter in Pediatric Patients, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 34(1), 114-118, 202001
  117. Effect of pulsed xenon ultraviolet disinfection on methicillin-resistant Staphylococcus aureus contamination of high-touch surfaces in a Japanese hospital, AMERICAN JOURNAL OF INFECTION CONTROL, 48(2), 139-142, 20200201
  118. Neurally adjusted ventilatory assist mitigates ventilator-induced diaphragm injury in rabbits, RESPIRATORY RESEARCH, 20(1), 20191223
  119. Ultrasonographic Detection of Micro-Bubbles in the Right Atrium to Confirm Peripheral Venous Catheter Position in Children, CRITICAL CARE MEDICINE, 47(10), E836-E840, 201910
  120. Successful treatment of extensive spinal epidural abscess with fluoroscopy-guided percutaneous drainage: a case report, JA CLINICAL REPORTS, 6(1), 20200115
  121. Impact of host- and early treatment-related factors on mortality in ICU patients with candidemia: a bicentric retrospective observational study, JOURNAL OF INTENSIVE CARE, 8(1), 20200426
  122. A Ruptured Mediastinal Bronchial Artery Aneurysm Treated with Urgent Thoracic Endovascular Aortic Repair, INTERNAL MEDICINE, 59(10), 1283-1286, 2020
  123. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study, LANCET RESPIRATORY MEDICINE, 7(2), 115-128, 201902
  124. Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study, JOURNAL OF CHEMOTHERAPY, 31(7-8), 388-393, 2019
  125. Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study, JOURNAL OF INTENSIVE CARE, 8(1), 20200723
  126. Successful treatment of extensive spinal epidural abscess with fluoroscopy-guided percutaneous drainage: a case report., JA Clin Rep, 6(1), 4-4, 20200115
  127. Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program., Crit Care Med., 48(2), 161-162, 202002
  128. A Ruptured Mediastinal Bronchial Artery Aneurysm Treated with Urgent Thoracic Endovascular Aortic Repair., Intern Med., 20200219
  129. Is Broad-Spectrum Antimicrobial Prophylaxis Ideal for Open-Chest Management?, Pediatr Crit Care Med., 21(3), 301-302, 202003
  130. Does nasal high-flow preoxygenation really reduce intubation-related adverse events?, Intensive Care Med., 20190819
  131. Confounding factors for the effect of misdiagnosis of site of infection on in-hospital mortality., Crit Care., 23(1), 294-294, 20190903
  132. ★, ASPECT-NP: a randomised, controlled, double-blind, phase 3, noninferiority trial of ceftolozane/tazobactam versus meropenem for treatment of nosocomial pneumonia., Lancet Infectious Diseases., 20190925
  133. Clinical and microbiologic outcomes by causative pathogen in the ASPECT-NP randomized, controlled, phase 3 trial evaluating ceftolozane/tazobactam for treatment of ventilated nosocomial pneumonia., Journal of Antimicrobial Chemotherapy., 2019
  134. Early Extubation for Infant Cardiac Surgery Supported by Dexmedetomidine Use., Pediatr Crit Care Med., 20(10), 989-990, 20191020
  135. Determination of the Appropriate Depth of Cuffed Endotracheal Tubes in Pediatric Intensive Care., Pediatr Crit Care Med., 20(11), 1101-1102, 20191120
  136. The Volume of Pediatric Blood Culture., Pediatr Infect Dis J., 38(12), 340-341, 201912
  137. Prolonged versus intermittent beta-lactam antibiotics intravenous infusion strategy in sepsis or septic shock patients: a systematic review with meta-analysis and trial sequential analysis of randomized trials, JOURNAL OF INTENSIVE CARE, 8(1), 20201006
  138. Ultrasound-guided peripheral vascular catheterization in pediatric patients: a narrative review, CRITICAL CARE, 24(1), 20200930
  139. Microglial translocator protein and stressor-related disorder, NEUROCHEMISTRY INTERNATIONAL, 140, 20201101
  140. Long-Axis In-Plane Approach Versus Short-Axis Out-of-Plane Approach for Ultrasound-Guided Central Venous Catheterization in Pediatric Patients: A Randomized Controlled Trial*, PEDIATRIC CRITICAL CARE MEDICINE, 21(11), E996-E1001, 20201101
  141. Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study), JOURNAL OF INTENSIVE CARE, 9(1), 20210106
  142. Hypothermia, Poorly Recognized by clinicians, is associated with Higher Mortality Among Critically Ill Patients with infections: A Retrospective Observational Study, JOURNAL OF INFECTION AND CHEMOTHERAPY, 27(3), 540-543, 20210301
  143. Proteins produced by Streptococcus species in the lower respiratory tract can modify antiviral responses against influenza virus in respiratory epithelial cells, MICROBES AND INFECTION, 23(1), 20210101
  144. Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis, CRITICAL CARE, 25(1), 20210409
  145. Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis, JOURNAL OF INTENSIVE CARE, 9(1), 20210412
  146. Frequency and Risk Factors for Reverse Triggering in Pediatric Acute Respiratory Distress Syndrome during Synchronized Intermittent Mandatory Ventilation, ANNALS OF THE AMERICAN THORACIC SOCIETY, 18(5), 820-829, 20210501
  147. ★, Save the ICU and save lives during the COVID-19 pandemic, JOURNAL OF INTENSIVE CARE, 8(1), 20200615
  148. A machine-learning based approach to quantify fine crackles in the diagnosis of interstitial pneumonia A proof-of-concept study, MEDICINE, 100(7), 20210219
  149. Prevalence of rapid response systems in small hospitals A questionnaire survey, MEDICINE, 100(23), 20210611
  150. Japanese rapid/living recommendations on drug management for COVID-19, ACUTE MEDICINE & SURGERY, 8(1), 20210101
  151. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model, SHOCK, 56(1), 142-149, 20210701
  152. Pediatric Fulminant Myocarditis in Japan: A Retrospective Nationwide Database Study of Hospital Volume, Management Practices, and Mortality, PEDIATRIC CRITICAL CARE MEDICINE, 22(7), E391-E401, 20210701
  153. Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial, CRITICAL CARE, 25(1), 20210811
  154. Further investigation of diagnostic errors in critically ill medical patients., Critical Care Medicine, 48(5), 433-434, 20200501
  155. Esophageal pressure and potential confounders for evaluating patient-ventilator asynchrony., J Crit Care, 60(344), 20200701
  156. Early Tracheostomy in Brain Injury: More Details Are Needed for Seeking Best Practice., Crit Care Med, 48(10), 984-985, 20201001
  157. Better Management of Delirium by Family Members., Crit Care Med, 48(11), 1161-1162, 20201101
  158. Microglial translocator protein and stressor-related disorder., Neurochem Int, 20201101
  159. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model., Shock., 56(1), 142-149, 20201204
  160. Early PaCO2 Changes after Initiating Extracorporeal Membrane Oxygenation: Considerations for Future Research., Am J Respir Crit Care Med, 202(11), 1600-1601, 20201201
  161. A novel system that continuously visualizes and analyzes respiratory sounds to promptly evaluate upper airway abnormalities: a pilot study, J Clin Monit Comput, 20210118
  162. Hypothermia, Poorly Recognized by clinicians, is associated with Higher Mortality Among Critically Ill Patients with infections: A Retrospective Observational Study, J Infect Chemother, 27(3), 540-543, 20210301
  163. Unclear Benefit of Early Tracheostomy In Patients With Coronavirus Disease 2019, Crit Care Med, 49(7), 721-722, 20210701
  164. Confounding Factors in a Study Investigating Mortality in Patients With Severe Hemoptysis, Crit Care Med, 49(4), 465-466, 20210401
  165. Frequency and Risk Factors for Reverse Triggering in Pediatric Acute Respiratory Distress Syndrome during Synchronized Intermittent Mandatory Ventilation, Ann Am Thorac Soc, 18(5), 820-829, 20210501
  166. Patient-ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis, JOURNAL OF INTENSIVE CARE, 9(1), 20210816
  167. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), Journal of Intensive Care, 8(1), 20210101
  168. The Association between Wearing a Mask and COVID-19, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(17), 20210901

Invited Lecture, Oral Presentation, Poster Presentation

  1. Emergency and ICU services of COVID-19 cases in Hiroshima University Hospital, Nobuaki SHime, Management of COVID-19 patients in Japan and Indosesia, 2020/06/04, With Invitation, English
  2. Ultrasound-guided catheter insertion in PICU, Shime N, The 7th World Congress on Pediatric Intensive and Critical Care, 2014/05/07, With Invitation, English, Istanbul
  3. Ventilator-associated events in pediatrics, Shime N, The 7th World Congress on Pediatric Intensive and Critical Care, 2014/05/07, With Invitation, English, Istanbul
  4. Comparison of three cutaneous antiseptic solutions for the prevention of catheter colonization in the adult intensive care unit : A multicenter prospective randomized controlled trial, Yasuda H, Sanui M, Komuro T, Hatakeyama J, Matsukubo S, Kawano S, Yamamoto H, Andoh K, Seo R, Shime N, The 35th international symposium on intensive and emergency medicine, 2015/03/18, With Invitation, English, Brussels
  5. Successful use of VAV ECMO in patient with respiratory failure complicated by myocarditis, M Kyo., S Ohshimo, Y Kida, T Shimatani, Y Torikoshi, K Suzuki, S Yamaga, N Hirohashi, N Shime, The 35th Annual Conference of KSCCM, 2016/04/23, Without Invitation, English
  6. Optimal Volume and Substance in Intraesophageal Balloon Catheter for Esophageal Pressure Measurement., T Shimatani, S Ohshimo, M Kyo, Y Kida, N Shime, The 35th Annual Conference of KSCCM, 2016/04/23, Without Invitation, Japanese
  7. Analysis of autopsy findings in patients with acute respiratory failure supported on V-V ECMO, Y Kida, S Ohshimo, M Kyo, T Shimatani, N Hirohashi, N Shime, The 35th Annual Conference of KSCCM, 2016/04/23, Without Invitation, Japanese
  8. Crinical Research in Japan., Shime N., Asia redional meeting in the 8th World Congress on Pedatric Intensive and Critical Care, 2016/06/05, Without Invitation, English, Tronto
  9. PREDICTORS FOR DETECTION OF DIFFICULT-TO-TREAT BACTERIA IN BILIARY TRACT INFECTION, Esaka N, Endo B, Shime N, 24th United European Gastroenterology Week, 2016/10, Without Invitation, English, Vienna
  10. Utility of continuous monitoring and visualizing system for respiratory sounds., Kikutani K, Ohshimo S, Ohki S, Giga H, Yamaga S, Sadamori T, Shime N, 第46回日本集中治療医学会学術集会, 2019/03/01, Without Invitation, English, Kyoto
  11. Association between apporopriate empiric antimicrobial therapy and mortalitu from bloodstream infections in the intensive care unit., Yamaga S, Shime N, Ohshimo S., 第46回日本集中治療医学会学術集会, 2019/03/02, Without Invitation, English, Kyoto
  12. Infection control in emergency departments in Japan., Sasaki J, KudoD, Shiino Y, Ikeda H, Shime N, Yokota H, The 18th. International Congress of Emergency Medicine, 2019/04/12, Without Invitation, Japanese, The 18th. International Congress of Emergency Medicine, Seoul
  13. Infection control in emergency departments in Japan., Sasaki J, KudoD, Shiino Y, Ikeda H, Shime N, Yokota H, The 18th. International Congress of Emergency Medicine, 2019/04/12, Without Invitation, English, Seoul
  14. Survey for infection control in emergency departments in Japan., Sasaki J, KudoD, Shiino Y, Ikeda H, Shime N, Ohge H, The 29th European Congress of Clinical Microbiology and Infectious Diseases, 2019/04/13, Without Invitation, English, The 29th European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam, Netherlands
  15. ASPECT-NP: a randomized, double-blind, phase III trial comparing efficacy and safety of ceftolozane/tazobactam versus meropenem in patients with ventilated nosocomial pneumonia (VNP), Kollef M, Novacek M, Kivisitk Ü, Réa-Neto Á, Shime N, Martin-Loeches I, Timsit J-F, Wunderink RG, Bruno CJ, Huntington JA, Lin K, Yu B, Butterton JR, Rhee EG., The 29th European Congress of Clinical Microbiology and Infectious Diseases, 2019/04/13, Without Invitation, English, The 29th European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam, Netherlands
  16. Survey for infection control in emergency departments in Japan., Sasaki J, KudoD, Shiino Y, Ikeda H, Shime N, Ohge H., The 29th European Congress of Clinical Microbiology and Infectious Diseases, 2019/04/13, Without Invitation, English, Amsterdam, Netherlands
  17. Clinical and microbiologic outcomes by causative pathogen in the ASPECT-NP randomized, controlled, phase 3 trial evaluating ceftolozane/tazobactam for treatment of ventilated nosocomial pneumonia (VNP), Martin-Loeches I, Kivisitk Ü, Nováček M, Rea-Neto A, Timsit J-F, Shime N, Wunderink RG, Kollef M, Bruno CJ, Huntington JA, Lin G, Yu B, Butterton JR, Rhee EG, The 22nd Annual MAD-ID Meeting, 2019/05/08, Without Invitation, English, The 22nd Annual MAD-ID Meeting, Orlando,Floroda
  18. ASPECT-NP: a randomized, double-blind, phase 3 trial comparing efficacy and safety of ceftolozane/tazobactam versus meropenem in patients with ventilated nosocomial pneumonia (VNP), Kollef M, Novacek M, Kivisitk U, Rea-Neto A, Shime N, Martin-Loeches I, Timsit J-F, Wunderink R, Bruno C, Huntington J, Lin K, Yu B, Butterton JR, Rhee EG, The 22nd Annual MAD-ID Meeting, 2019/05/08, Without Invitation, English, The 22nd Annual MAD-ID Meeting, Orlando,Floroda
  19. Outcomes in patients with ventilated nosocomial pneumonia (NP) and organ failure treated with ceftolozane/tazobactam (C/T) vs meropenem (MER) - analysis of the ASPECT-NP randomized, controlled trial., Martin-Loeches I, Bruno CJ, Shime N, Wunderink RG, Kollef M, Kivistik Ü, Nováček M, Réa-Neto A, Timsit J-F, Yu B, Huntington JA, Jensen E, Butterton JR, Rhee EG, Shorr AF., ESICM (2019) European Society of Intensive Care Medicine 32nd Annual Congress., 2019/09/30, Without Invitation, English, ESICM, Berlin
  20. Ceftolozane/tazobactam (C/T) vs meropenem (MEM) in patients with ventilated hospital-acquired pneumonia (vHAP) – subset analysis of the ASPECT-NP randomized, controlled, phase 3 trial., Timsit J-F, Huntington JA, Wunderink RG, Shime N, Kollef M, Kivistik Ü, Nováček M, Réa-Neto A, Martin-Loeches I, Yu B, Bruno CJ, Jensen E, Butterton JR, Wolf DJ, Rhee EG., ESICM (2019) European Society of Intensive Care Medicine 32nd Annual Congress., 2019/09/30, Without Invitation, English, ESICM (2019) European Society of Intensive Care Medicine 32nd Annual Congress., Berlin

External Funds

Acceptance Results of Competitive Funds

  1. 2021, 2022
  2. 2011, 2014
  3. 2012, 2016
  4. 2014, 2014
  5. 2017, 2019
  6. 2017, 2019
  7. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  8. 2017/.4, 2018/.3
  9. 2017/.6
  10. Development of Medical Devices and Systems for Advanced Medical Services , 2017/08/01, 2018/03/31
  11. Development of Medical Devices and Systems for Advanced Medical Services , 2018/04/01, 2019/03/31
  12. Development of Medical Devices and Systems for Advanced Medical Services, Development of Medical Devices and Systems for Advanced Medical Services, 2019, 2019
  13. 2019, 2020
  14. Acceleration Transformative Research for Medical Innovation, 2019/04/01, 2020/03/31
  15. 2020, 2020
  16. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2020, 2023
  17. Acceleration Transformative Research for Medical Innovation, 2020/04/01, 2021/09/30
  18. 2020, 2021
  19. Development of Medical Devices and Systems for Advanced Medical Services, Development of Medical Devices and Systems for Advanced Medical Services, 2020, 2020

Social Activities

History as Committee Members

  1. 2010

Organizing Academic Conferences, etc.

  1. 2020/12, 2020/12
  2. 2018/12, 2018/12
  3. 2018/05, 2018/05
  4. 2018/10, 2018/10
  5. 2017/06, 2017/06
  6. 2016/06, 2016/06
  7. 2017/05, 2017/05
  8. 2016/09, 2016/09

Other Social Contributions

  1. ECMO simulation labo., ECMO simulation labo., NPO ECMO JAPAN, 2019/08/31, 2019/09/01, Planner, Seminar or workshop, Scientific organization
  2. ECMO simulation labo., ECMO simulation labo., NPO ECMO JAPAN, 2017/05/27, 2017/05/28, Planner, Seminar or workshop, Scientific organization
  3. PALS provider course, PALS provider course, JIPICC, 2019/08/17, 2019/08/18, Planner, Seminar or workshop, Scientific organization

History as Peer Reviews of Academic Papers

  1. 2020, International Journal of Infectious Diseases, 1
  2. 2020, Acute Medicine & Surgery, 4
  3. 2020, BMJ open, 2
  4. 2020, Cardiovascular Diagnosis and Therapy, 1
  5. 2020, Journal of International Medical Research, Others, 1
  6. 2020, Journal of Japanese Association for Acute Medicine, 4
  7. 2020, J of Artificial Organs, 2
  8. Liver International, 1
  9. 2020, Pediatrics International, 1
  10. 2020, Respiratory Medicine Case Reports, 4
  11. 2020, The Lancet Regional health western pacific, 1
  12. 2020, J Clinical Microbiology, Others, 1
  13. 2020, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2
  14. 2020, J of Infection and Chemotherapy, 6
  15. 2020, Pediatric Critical Care Medicine, Editor, Associate Editor, 14
  16. 2020, J Intensive Care, Editor, 14
  17. 2019, Infect Drug Resist, 3
  18. Pros One, Others, 1
  19. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Others, 1
  20. 2019, Clinical Interventions in Aging, Others, 1
  21. 2019, Pedaitr Crit Care Med, Editor, 11
  22. 2019, J Intensive care, Editor, 5
  23. 2018, J of Artif Organs, Others, 2
  24. 2018, J Antimicrobial Chemother, 1
  25. 2018, Med Sci Monitoring, Others, 1
  26. 2018, Int J Infect Dis, Others, 1
  27. 2018, Clinical epidemiology, Others, 1
  28. 2018, BMC pediatrics, Others, 1
  29. 2018, J Infect Chemother, Others, 4
  30. 2018, Pediatr Crit Care Med, Editor, 11
  31. 2018, J intensive care, Others, Deputy Editor, 15
  32. 2017, Acute Medicine and Surgery, Others, 1
  33. 2017, BMC pediatrics, Others, 1
  34. 2017, European Respiratory Reviews, Others, 1
  35. 2017, BMC Anesthesiology, Others, 1
  36. 2017, J Artif Organs, Others, 1
  37. 2017, Pulsus Journals, Others, 1
  38. 2017, J Antimicrobial Chemother, Others, 1
  39. 2017, J of Infection and Chemotherapy, Others, 2
  40. 2017, J of Anesthesia, Others, 5
  41. 2017, Pediatr Crit Care Med, Editor, 16
  42. 2017, Pediatrics International, Editor, 9
  43. 2017, Journal of Intensive Care, Editor, 4
  44. 2016, Internal Medicine, Others, 1
  45. 2016, Journal of Cirtical Care, Others, 1
  46. 2016, Hospital practice, Others, 1
  47. 2016, Respiratory Medicine Case Reports, Others, 1
  48. 2016, BMC Anesthesiology, Others, 1
  49. 2016, Journal of Anesthesia, Others, 3
  50. 2016, Pediatrics international, Editor, 10
  51. 2016, Journal of Infection and Chemotherapy, Editor, 2
  52. 2016, Pediatric Critical Care Medicine, Editor, 12
  53. 2016, Journal of Intensive Care, Editor, 6
  54. 2015, Circulation Journal, Others, Reviewer, 1
  55. 2015, Hospital Practice, Others, Reviewer, 1
  56. 2015, Journal of Infection and Chemotherapy, Reviewer, 4
  57. 2015, Journal of Anesthesia, Editor, Reviewer, 4
  58. 2015, Journal of Japanese Society of Intensive Care Medicine, Others, Reviewer, 2
  59. 2015, Journal of Japanese Sciety of Surgical Infection, Editor, Editor, 4
  60. 2015, Journal of Intensive Care, Editor, Reviewer, 17
  61. 2015, Journal of Intensive Care, Editor, Associate Editor, 4
  62. 2015, Pediatrics International, Editor, Editor, 71
  63. 2015, Pediatric Critical Care Medicine, Editor, Associate Editor, 15
  64. 2015, Pediatrics International, Others, Reviewer, 2