NOBUAKI SHIME

Last Updated :2024/07/23

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
nshimehiroshima-u.ac.jp
Self-introduction
Emergency and Critical Care Medicine

Basic Information

Major Professional Backgrounds

  • 2020, Kyoto Prefectural University of Medicine, Visiting Professor
  • 2020, Doshisha University, Visiting Professor

Academic Degrees

  • Kyoto Prefectural University of Medicine

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Emergency medicine

Research Keywords

  • sepsis, antibiotics, pneumonia, ECMO, ARDS

Affiliated Academic Societies

  • Japanese Society of Intensive Care Medicine
  • Japanese Association of Acute Medicine
  • Japanese Society of Infectious Disease
  • Japanese Society of Antimicrobial and Chemotherapy

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, Year, Systemic Disease Control
  2. 2024, Undergraduate Education, Intensive, Practice for medical research
  3. 2024, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2024, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2024, Undergraduate Education, Second Semester, Emergency and Critical Care Medicine
  6. 2024, Graduate Education (Master's Program) , 2Term, Multidisciplinary Cooperation A
  7. 2024, Graduate Education (Doctoral Program) , 2Term, Multidisciplinary Cooperation B
  8. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Emergency and Critical Care Medicine
  9. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Emergency and Critical Care Medicine
  10. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Emergency and Critical Care Medicine
  11. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Emergency and Critical Care Medicine

Research Activities

Academic Papers

  1. Bacterial profiles detected in ventilator-associated pneumonia in Japan: A systematic review, RESPIRATORY INVESTIGATION, 62(3), 365-368, 202405
  2. The Current Discussion Regarding End-of-Life Care for Patients with Out-of-Hospital Cardiac Arrest with Initial Non-Shockable Rhythm: A Narrative Review, MEDICINA-LITHUANIA, 60(4), 202404
  3. External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study, SCIENTIFIC REPORTS, 14(1), 20240221
  4. Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest, MEDICINA-LITHUANIA, 60(3), 202403
  5. Epidemiology and patterns of empiric antimicrobial therapy practice in patients with community-onset sepsis using data from a Japanese nationwide medical claims database -the Japan Sepsis Alliance (JaSA) study group, IJID REGIONS, 10, 162-167, 202403
  6. High versus low positive end-expiratory pressure setting in patients receiving veno-venous extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome: study protocol for the multicentre, randomised ExPress SAVER Trial, BMJ OPEN, 13(10), 202310
  7. Predictive Accuracy of the ROX Index for Re-Intubation in Mechanically Ventilated Patients With COVID-19, RESPIRATORY CARE, 68(8), 1067-1074, 20230801
  8. Association between hospital spending and in-hospital mortality of patients with sepsis based on a Japanese nationwide medical claims database study, HELIYON, 10(1), 20240115
  9. New acoustic monitoring system quantifying aspiration risk during monitored anaesthesia care, SCIENTIFIC REPORTS, 13(1), 20231118
  10. Usefulness of new acoustic respiratory sound monitoring with artificial intelligence for upper airway assessment in obese patients during monitored anesthesia care, JOURNAL OF MEDICAL INVESTIGATION, 70(3-4), 430-435, 202308
  11. Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry, JOURNAL OF INTENSIVE CARE, 12(1), 20240126
  12. Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study, JOURNAL OF INTENSIVE CARE, 12(1), 20240130
  13. Carbapenem vs. non-carbapenem antibiotics for ventilator-associated pneumonia: A systematic review with meta-analysis, RESPIRATORY INVESTIGATION, 62(2), 200-205, 202403
  14. A Successful Prevention of Reintubation Using the Mechanical Insufflation-Exsufflation in a Critically Ill Patient With Impaired Airway Mucus Expectoration: A Case Report, CUREUS JOURNAL OF MEDICAL SCIENCE, 15(10), 20231027
  15. Prediction of the neurological outcomes post-cardiac arrest: A prospective validation of the CAST and rCAST, AMERICAN JOURNAL OF EMERGENCY MEDICINE, 75, 46-52, 202401
  16. Ultrasound-Guided Short-Axis Out-of-Plane Approach With or Without Dynamic Needle-Tip Positioning for Peripheral Venous Catheterization in Pediatric Patients: A Systematic Review With Network Meta-Analysis, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 37(10), 2057-2064, 202310
  17. Comparison of radial, dorsalis pedis, and posterior tibial arteries for ultrasound-guided arterial catheterisation with dynamic needle tip positioning in paediatric patients: a randomised controlled trial, BRITISH JOURNAL OF ANAESTHESIA, 131(4), 739-744, 202310
  18. Efficacy of perioperative prophylactic administration of corticosteroids in pediatric cardiac surgeries using cardiopulmonary bypass: a systematic review with meta-analysis, ANAESTHESIA CRITICAL CARE & PAIN MEDICINE, 42(6), 202312
  19. Multisystem inflammatory syndrome in adults with COVID-19 requiring mechanical ventilation: A retrospective cohort study, ACUTE MEDICINE & SURGERY, 10(1), 202301
  20. Use of a laryngeal tube for sialolithotomy in a pediatric patient with left vocal cord paralysis: a case report, JA CLINICAL REPORTS, 9(1), 20230617
  21. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19, SCIENTIFIC DATA, 9(1), 20220730
  22. Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department, SCIENTIFIC REPORTS, 13(1), 20230403
  23. Impact of the failure of initial insertion of a peripheral intravascular catheter on the development of adverse events in patients admitted to the intensive care unit from the emergency room: A post hoc analysis of the AMOR-VENUS study, ACUTE MEDICINE & SURGERY, 10(1), 202301
  24. Lethal Interstitial Lung Disease Associated with a Gain-of-Function Mutation in IFIH1., J Clin Immunol, Epub ahead of print, 202305
  25. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study., Lancet Respir Med, 11(5), 465-476, 20230121
  26. Temperature management using an intervascular cooling device for a COVID-19 patient with refractory hyperthermia., Clin Case Rep, 11(4), e7138-e7138, 20230407
  27. Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department., Sci Rep, 13(1), 5433-5433, 20230403
  28. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19., Int J Epidemiol, 52(2), 355-376, 20230419
  29. Neurological manifestations of COVID-19 in adults and children. Brain., Brain, 146(6), 1648-1661, 20230419
  30. Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post- cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial., EClinicalMedicine, 58, 101907, 20230317
  31. A study of the risk factors for phlebitis in patients stratified using the acute physiology and chronic health evaluation II score and admitted to the intensive care unit: A post hoc analysis of the AMOR-VENUS study., Front Med (Lausanne)., 9, 965706, 20221205
  32. An algorithm for PCT-guided antimicrobial therapy: a consensus statement by Japanese experts., Clin Chem Lab Med, 61(3), 407-411, 20221202
  33. Risk factors for peripheral venous catheter- related phlebitis stratified by body mass index in critically ill patients: A post-hoc analysis of the AMOR-VENUS study., Front Med (Lausanne), 9, 1037274, 20221128
  34. Unexpected cholinergic crisis caused by distigmine bromide: A case report., Medicine (Baltimore), 101(47), e31677-e31677, 20221125
  35. Trends in survival during the pandemic in patients with critical COVID-19 receiving mechanical ventilation with or without ECMO: analysis of the Japanese national registry data., Crit Care, 26(1), 354-354, 20221115
  36. Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study., J Intensive Care, 10(1), 49-49, 20221029
  37. A burden of fluid, sodium, and chloride due to intravenous fluid therapy in patients with respiratory support: a post-hoc analysis of a multicenter cohort study., Ann Intensive Care, 12(1), 100-100, 20221022
  38. Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (July 2022)., Acute Med Surg, 9(1), e789-e789, 20221019
  39. The research environment of critical care in three Asian countries: A cross-sectional questionnaire survey., Front Med (Lausanne), 9, 975750, 20220920
  40. Controversial Efficacy of Prone-Positioning for Patients With Severe Acute Respiratory Distress Syndrome Undergoing Venous-Venous Extracorporeal Membrane Oxygenation., Crit Care Med, 50(9), e725-e726, 202209
  41. Effect of wearing a surgical mask on short-term pulmonary gas exchange in patients immediately after anaesthesia., Indian J Anaesth., 66(8), 617-619, 202208
  42. Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS, RESPIRATORY RESEARCH, 24(1), 20230510
  43. Ultrasound-guided short-axis out-of-plane approach with or without dynamic needle tip positioning for arterial line insertion in children: A systematic review with network meta-analysis, ANAESTHESIA CRITICAL CARE & PAIN MEDICINE, 42(3), 202306
  44. Temperature management using an intervascular cooling device for a COVID-19 patient with refractory hyperthermia, CLINICAL CASE REPORTS, 11(4), 202304
  45. An algorithm for PCT-guided antimicrobial therapy: a consensus statement by Japanese experts, CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 61(3), 407-411, 20230223
  46. The Current and Future State of Pediatric Sepsis Definitions: An International Survey, PEDIATRICS, 149(6), 202206
  47. GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL, SHOCK, 59(1), 82-90, 202301
  48. Combined short-axis out-of-plane and long-axis in-plane approach versus long-axis in-plane approach for ultrasound-guided central venous catheterization in infants and small children: A randomized controlled trial, PLOS ONE, 17(9), 20220930
  49. Case Report: Emphysematous Pyelonephritis With a Congenital Giant Ureterocele, FRONTIERS IN PEDIATRICS, 9, 20211126
  50. Quantification of respiratory sounds by a continuous monitoring system can be used to predict complications after extubation: a pilot study, JOURNAL OF CLINICAL MONITORING AND COMPUTING, 37(1), 237-248, 202302
  51. Unexpected cholinergic crisis caused by distigmine bromide: A case report, MEDICINE, 101(47), 20221125
  52. Risk factors for peripheral venous catheter-related phlebitis stratified by body mass index in critically ill patients: A post-hoc analysis of the AMOR-VENUS study, FRONTIERS IN MEDICINE, 9, 20221128
  53. A study of the risk factors for phlebitis in patients stratified using the acute physiology and chronic health evaluation II score and admitted to the intensive care unit: A post hoc analysis of the AMOR-VENUS study, FRONTIERS IN MEDICINE, 9, 20221205
  54. Deep sedation predicts pressure injury in patients admitted to intensive care units, NURSING IN CRITICAL CARE, 27(6), 877-884, 202211
  55. Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group, JOURNAL OF INTENSIVE CARE, 11(1), 20230107
  56. Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19, JOURNAL OF CLINICAL IMMUNOLOGY, 42(7), 1360-1370, 202210
  57. ARDS clinical practice guideline 2021, RESPIRATORY INVESTIGATION, 60(4), 446-495, 202207
  58. Trends in survival during the pandemic in patients with critical COVID-19 receiving mechanical ventilation with or without ECMO: analysis of the Japanese national registry data, CRITICAL CARE, 26(1), 20221115
  59. A burden of fluid, sodium, and chloride due to intravenous fluid therapy in patients with respiratory support: a post-hoc analysis of a multicenter cohort study, ANNALS OF INTENSIVE CARE, 12(1), 20221022
  60. The research environment of critical care in three Asian countries: A cross-sectional questionnaire survey, FRONTIERS IN MEDICINE, 9, 20220920
  61. Regional respiratory sound abnormalities in pneumothorax and pleural effusion detected via respiratory sound visualization and quantification: case report, JOURNAL OF CLINICAL MONITORING AND COMPUTING, 36(6), 1761-1766, 202212
  62. Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (July 2022), ACUTE MEDICINE & SURGERY, 9(1), 202201
  63. Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study, JOURNAL OF INTENSIVE CARE, 10(1), 20221029
  64. Incidence of catheter-related bloodstream infections following ultrasound-guided central venous catheterization: a systematic review and meta-analysis, BMC INFECTIOUS DISEASES, 22(1), 20221004
  65. Controversial Efficacy of Prone-Positioning for Patients With Severe Acute Respiratory Distress Syndrome Undergoing Venous-Venous Extracorporeal Membrane Oxygenation., Crit Care Med, 50(9), e725-e726, 20220901
  66. Purpura fulminans due to Rickettsia japonica., QJM, 115(11), 758-759, 20221114
  67. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19., Sci Data, 9(1), 454, 20220730
  68. Alarming of Severe Respiratory Failure Requiring ECMO Caused by the SARS-CoV-2 Omicron Variant., JMA J, 5(3), 370-371, 20220715
  69. Temporal trends of medical cost and cost-effectiveness in sepsis patients: a Japanese nationwide medical claims database, JOURNAL OF INTENSIVE CARE, 10(1), 20220714
  70. ARDS Clinical Practice Guideline 2021, JOURNAL OF INTENSIVE CARE, 10(1), 20220708
  71. ARDS clinical practice guideline 2021, Respir Investig, 60(4), 446-495, 20220701
  72. Effect of region-wide use of prehospital stroke triage scale on management of patients with acute stroke, JOURNAL OF NEUROINTERVENTIONAL SURGERY, 14(7), 677-682, 20220701
  73. Neutralizing Type I Interferon Autoantibodies in Japanese Patients With Severe COVID-19., J Clin Immunol, 42(7), 1360-1370, 202210
  74. Quantification of respiratory sounds by a continuous monitoring system can be used to predict complications after extubation: a pilot study., J Clin Monit Comput, Epub ahead of print, 20220622
  75. Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out-of-Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 11(12), 20220621
  76. The Current and Future State of Pediatric Sepsis Definitions: An International Survey, Pediatrics, 149(6), 20220601
  77. Resource-rich Intensive Care Units Improve Health-What Is Next?, JMA J, 5(2), 285, 20220415
  78. Risk factors for peripheral intravascular catheter-related phlebitis in critically ill patients: analysis of 3429 catheters from 23 Japanese intensive care units, ANNALS OF INTENSIVE CARE, 12(1), 20220408
  79. Clinical and microbiological outcomes, by causative pathogen, in the ASPECT-NP randomized, controlled, Phase 3 trial comparing ceftolozane/tazobactam and meropenem for treatment of hospital-acquired/ventilator-associated bacterial pneumonia, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 77(4), 1166-1177, 20220331
  80. Short- versus prolonged-course antibiotic therapy for sepsis or infectious diseases in critically ill adults: a systematic review and meta-analysis, INFECTIOUS DISEASES, 54(3), 213-223, 20220304
  81. Regional respiratory sound abnormalities in pneumothorax and pleural effusion detected via respiratory sound visualization and quantification: case report., J Clin Monit Comput, Epub ahead of print, 20220211
  82. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system., Clin Exp Dent Res, 8(1), 225-230, 20220201
  83. Deep sedation predicts pressure injury in patients admitted to intensive care units., Nurs Crit Care, Epub ahead of print, 20220119
  84. Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study., Crit Care, 26(1), 2, 20220103
  85. Potential Confounders in Evaluating the Impact of Hyperoxia on Neurological Outcomes in Patients Receiving Extracorporeal Membrane Oxygenation., Crit Care Med, 50(1), e97-e98, 20220101
  86. Concerning the Association Between Delayed Administration of Antibiotics and Mortality in Patients With Suspected Sepsis., Crit Care Med, 50(1), e87-e88, 20220101
  87. Changes in pediatric intensive care unit cases due to the novel coronavirus., Pediatr Int, 64(1), e15019, 20220101
  88. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system, CLINICAL AND EXPERIMENTAL DENTAL RESEARCH, 8(1), 225-230, 202202
  89. A novel system that continuously visualizes and analyzes respiratory sounds to promptly evaluate upper airway abnormalities: a pilot study, JOURNAL OF CLINICAL MONITORING AND COMPUTING, 36(1), 221-226, 202202
  90. Changes in pediatric intensive care unit cases due to the novel coronavirus, PEDIATRICS INTERNATIONAL, 64(1), 202201
  91. Duration of infectious virus shedding in patients with severe coronavirus disease 2019 who required mechanical ventilation, JOURNAL OF INFECTION AND CHEMOTHERAPY, 28(1), 19-23, 202201
  92. Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort., Elife., e70970, 20211123
  93. Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group, CRITICAL CARE, 25(1), 20210916
  94. The Association between Wearing a Mask and COVID-19, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(17), 20210901
  95. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), JOURNAL OF INTENSIVE CARE, 9(1), 20210825
  96. Patient-ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis, JOURNAL OF INTENSIVE CARE, 9(1), 20210816
  97. Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial, CRITICAL CARE, 25(1), 20210811
  98. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model, SHOCK, 56(1), 142-149, 20210701
  99. Pediatric Fulminant Myocarditis in Japan: A Retrospective Nationwide Database Study of Hospital Volume, Management Practices, and Mortality, PEDIATRIC CRITICAL CARE MEDICINE, 22(7), E391-E401, 20210701
  100. Unclear Benefit of Early Tracheostomy In Patients With Coronavirus Disease 2019, Crit Care Med, 49(7), 721-722, 20210701
  101. The right care at the right place: Significance of intensive care units for critically ill patients., Lancet Reg Health West Pac, 13, 100198, 20210620
  102. Prevalence of rapid response systems in small hospitals A questionnaire survey, MEDICINE, 100(23), 20210611
  103. Frequency and Risk Factors for Reverse Triggering in Pediatric Acute Respiratory Distress Syndrome during Synchronized Intermittent Mandatory Ventilation, ANNALS OF THE AMERICAN THORACIC SOCIETY, 18(5), 820-829, 20210501
  104. Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis, JOURNAL OF INTENSIVE CARE, 9(1), 20210412
  105. Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis, CRITICAL CARE, 25(1), 20210409
  106. Confounding Factors in a Study Investigating Mortality in Patients With Severe Hemoptysis, Crit Care Med, 49(4), 465-466, 20210401
  107. Hypothermia, Poorly Recognized by clinicians, is associated with Higher Mortality Among Critically Ill Patients with infections: A Retrospective Observational Study, JOURNAL OF INFECTION AND CHEMOTHERAPY, 27(3), 540-543, 20210301
  108. A machine-learning based approach to quantify fine crackles in the diagnosis of interstitial pneumonia A proof-of-concept study, MEDICINE, 100(7), 20210219
  109. A novel system that continuously visualizes and analyzes respiratory sounds to promptly evaluate upper airway abnormalities: a pilot study, J Clin Monit Comput, 20210118
  110. Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study), JOURNAL OF INTENSIVE CARE, 9(1), 20210106
  111. Proteins produced by Streptococcus species in the lower respiratory tract can modify antiviral responses against influenza virus in respiratory epithelial cells, MICROBES AND INFECTION, 23(1), 20210101
  112. Japanese rapid/living recommendations on drug management for COVID-19, ACUTE MEDICINE & SURGERY, 8(1), 20210101
  113. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), Journal of Intensive Care, 8(1), 20210101
  114. The value of open-source clinical science in pandemic response: lessons from ISARIC., Lancet Infect Dis, 21(12), 1623-1624, 202112
  115. Differential Effectiveness of Hypothermic Targeted Temperature Management According to the Severity of Post-Cardiac Arrest Syndrome, JOURNAL OF CLINICAL MEDICINE, 10(23), 202112
  116. Efficacy and safety of 1.5% aqueous olanexidine gluconate antiseptic solution compared to 1% alcoholic chlorhexidine for the prevention of intravenous catheter-related infections (Apollo study): a protocol for a randomised controlled trial, BMJ OPEN, 11(12), 202112
  117. Case Report: Emphysematous Pyelonephritis With a Congenital Giant Ureterocele., Front Pediatr, 26(9), 775468, 202111
  118. Identification of Aggravation-Predicting Gene Polymorphisms in Coronavirus Disease 2019 Patients Using a Candidate Gene Approach Associated With Multiple Phase Pathogenesis: A Study in a Japanese City of 1 Million People., Crit Care Explor, 3(11), e0576-e0576, 202111
  119. Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (September 2021), Acute Med Surg, 8(1), e706-e706, 202111
  120. Did the Effect of the Guidelines eVAPorate? The Need for Improved Antimicrobial Stewardship Continues., Pediatr Crit Care Med, 22(10), 925-927, 202110
  121. COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study., Infection, 49(5), 889-905, 202110
  122. Combining pulsed xenon ultraviolet disinfection with terminal manual cleaning helps reduce the acquisition rate of methicillin-resistant Staphylococcus aureus, AMERICAN JOURNAL OF INFECTION CONTROL, 49(8), 1048-1051, 202108
  123. Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study., Intensive Care Med, 47(4), 503-520, 202104
  124. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), ACUTE MEDICINE & SURGERY, 8(1), 202101
  125. Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (September 2021), ACUTE MEDICINE & SURGERY, 8(1), 202101
  126. Early PaCO2 Changes after Initiating Extracorporeal Membrane Oxygenation: Considerations for Future Research., Am J Respir Crit Care Med, 202(11), 1600-1601, 20201201
  127. Microglial translocator protein and stressor-related disorder, NEUROCHEMISTRY INTERNATIONAL, 140, 20201101
  128. Long-Axis In-Plane Approach Versus Short-Axis Out-of-Plane Approach for Ultrasound-Guided Central Venous Catheterization in Pediatric Patients: A Randomized Controlled Trial*, PEDIATRIC CRITICAL CARE MEDICINE, 21(11), E996-E1001, 20201101
  129. Better Management of Delirium by Family Members., Crit Care Med, 48(11), 1161-1162, 20201101
  130. Microglial translocator protein and stressor-related disorder., Neurochem Int, 20201101
  131. Prolonged versus intermittent beta-lactam antibiotics intravenous infusion strategy in sepsis or septic shock patients: a systematic review with meta-analysis and trial sequential analysis of randomized trials, JOURNAL OF INTENSIVE CARE, 8(1), 20201006
  132. Early Tracheostomy in Brain Injury: More Details Are Needed for Seeking Best Practice., Crit Care Med, 48(10), 984-985, 20201001
  133. Ultrasound-guided peripheral vascular catheterization in pediatric patients: a narrative review, CRITICAL CARE, 24(1), 20200930
  134. Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study, JOURNAL OF INTENSIVE CARE, 8(1), 20200723
  135. Esophageal pressure and potential confounders for evaluating patient-ventilator asynchrony., J Crit Care, 60(344), 20200701
  136. ★, Save the ICU and save lives during the COVID-19 pandemic, JOURNAL OF INTENSIVE CARE, 8(1), 20200615
  137. Further investigation of diagnostic errors in critically ill medical patients., Critical Care Medicine, 48(5), 433-434, 20200501
  138. Impact of host- and early treatment-related factors on mortality in ICU patients with candidemia: a bicentric retrospective observational study, JOURNAL OF INTENSIVE CARE, 8(1), 20200426
  139. A Ruptured Mediastinal Bronchial Artery Aneurysm Treated with Urgent Thoracic Endovascular Aortic Repair., Intern Med., 20200219
  140. Effect of pulsed xenon ultraviolet disinfection on methicillin-resistant Staphylococcus aureus contamination of high-touch surfaces in a Japanese hospital, AMERICAN JOURNAL OF INFECTION CONTROL, 48(2), 139-142, 20200201
  141. Successful treatment of extensive spinal epidural abscess with fluoroscopy-guided percutaneous drainage: a case report, JA CLINICAL REPORTS, 6(1), 20200115
  142. Successful treatment of extensive spinal epidural abscess with fluoroscopy-guided percutaneous drainage: a case report., JA Clin Rep, 6(1), 4-4, 20200115
  143. Decreased intracellular histamine concentration and basophil activation in anaphylaxis, ALLERGOLOGY INTERNATIONAL, 69(1), 78-83, 20200101
  144. Is Broad-Spectrum Antimicrobial Prophylaxis Ideal for Open-Chest Management?, Pediatr Crit Care Med., 21(3), 301-302, 202003
  145. Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program., Crit Care Med., 48(2), 161-162, 202002
  146. Dynamic Needle Tip Positioning for Ultrasound-Guided Placement of a Peripherally Inserted Central Catheter in Pediatric Patients, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 34(1), 114-118, 202001
  147. A Ruptured Mediastinal Bronchial Artery Aneurysm Treated with Urgent Thoracic Endovascular Aortic Repair, INTERNAL MEDICINE, 59(10), 1283-1286, 2020
  148. Neurally adjusted ventilatory assist mitigates ventilator-induced diaphragm injury in rabbits, RESPIRATORY RESEARCH, 20(1), 20191223
  149. Determination of the Appropriate Depth of Cuffed Endotracheal Tubes in Pediatric Intensive Care., Pediatr Crit Care Med., 20(11), 1101-1102, 20191120
  150. Unique patterns of lower respiratory tract microbiota are associated with inflammation and hospital mortality in acute respiratory distress syndrome, RESPIRATORY RESEARCH, 20(1), 20191106
  151. Early Extubation for Infant Cardiac Surgery Supported by Dexmedetomidine Use., Pediatr Crit Care Med., 20(10), 989-990, 20191020
  152. Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome An International Multicenter Prospective Cohort, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(8), 1002-1012, 20191015
  153. ★, ASPECT-NP: a randomised, controlled, double-blind, phase 3, noninferiority trial of ceftolozane/tazobactam versus meropenem for treatment of nosocomial pneumonia., Lancet Infectious Diseases., 20190925
  154. Confounding factors for the effect of misdiagnosis of site of infection on in-hospital mortality., Crit Care., 23(1), 294-294, 20190903
  155. Does nasal high-flow preoxygenation really reduce intubation-related adverse events?, Intensive Care Med., 20190819
  156. Comparison of video and conventional laryngoscopes for simulated difficult emergency tracheal intubations in the presence of liquids in the airway, PLOS ONE, 14(7), 20190719
  157. Decreased intracellular histamine concentration and basophil activation in anaphylaxis., Allergol International Available online, 20190624
  158. Superiority of Dynamic Needle Tip Positioning for Ultrasound-Guided Peripheral Venous Catheterization in Patients Younger Than 2 Years Old: A Randomized Controlled Trial., Pediatr Crit Care Med., 20190618
  159. Is lung ultrasonography really useful for diagnosing weaning-induced pulmonary oedema?, Intensive Care Med., 20190606
  160. Combined Approach Versus 2 Conventional Approaches in Ultrasound-Guided Central Venous Catheterization: A Randomized Controlled Trial., J Cardiothorac Vasc Anesth., 20190528
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  163. ★, A Therapeutic Strategy for All Pneumonia Patients: A 3-Year Prospective Multicenter Cohort Study Using Risk Factors for Multidrug-resistant Pathogens to Select Initial Empiric Therapy, CLINICAL INFECTIOUS DISEASES, 68(7), 1080-1088, 20190401
  164. Comparison of three video laryngoscopes and direct laryngoscopy for emergency endotracheal intubation: a retrospective cohort study., BMJ Open., 9(3), 024927-024927, 20190330
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  166. Baseline High-Resolution CT Findings Predict Acute Exacerbation of Idiopathic Pulmonary Fibrosis: German and Japanese Cohort Study, JOURNAL OF CLINICAL MEDICINE, 8(12), 201912
  167. The Volume of Pediatric Blood Culture., Pediatr Infect Dis J., 38(12), 340-341, 201912
  168. Combined Approach Versus 2 Conventional Approaches in Ultrasound-Guided Central Venous Catheterization: A Randomized Controlled Trial, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 33(11), 2979-2984, 201911
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  170. Ultrasonographic Detection of Micro-Bubbles in the Right Atrium to Confirm Peripheral Venous Catheter Position in Children, CRITICAL CARE MEDICINE, 47(10), E836-E840, 201910
  171. Superiority of Dynamic Needle Tip Positioning for Ultrasound-Guided Peripheral Venous Catheterization in Patients Younger Than 2 Years Old: A Randomized Controlled Trial*, PEDIATRIC CRITICAL CARE MEDICINE, 20(9), e410-e414, 201909
  172. Dynamic Needle Tip Positioning for Ultrasound Guided Arterial Catheterization in Infants and Small Children With Deep Arteries: A Randomized Controlled Trial, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 33(7), 1919-1925, 201907
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  175. Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study., J Chemother., 30, 1-6, 201905
  176. Comparing Combined Short-Axis and Long-Axis Ultrasound-Guided Central Venous Catheterization update, With Conventional Short-Axis Out-of-Plane Approaches, JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 33(4), 1029-1034, 201904
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  178. Potential confounders for the effect of high-flow nasal cannula oxygen therapy., Crit Care., 23(1), 17-17, 201901
  179. High serum potassium level is associated with successful electrical cardioversion for new-onset atrial fibrillation in the intensive care unit: A retrospective observational study., Anaesth Intensive Care., 47(1), 52-59, 201901
  180. High serum potassium level is associated with successful electrical cardioversion for new-onset atrial fibrillation in the intensive care unit: A retrospective observational study, ANAESTHESIA AND INTENSIVE CARE, 47(1), 52-59, 201901
  181. Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study, JOURNAL OF CHEMOTHERAPY, 31(7-8), 388-393, 2019
  182. Clinical and microbiologic outcomes by causative pathogen in the ASPECT-NP randomized, controlled, phase 3 trial evaluating ceftolozane/tazobactam for treatment of ventilated nosocomial pneumonia., Journal of Antimicrobial Chemotherapy., 2019
  183. The western Japan chaotic rainstorm disaster: a brief report from Hiroshima., J Intensive Care., 6, 82-82, 20181217
  184. Should We Abandon Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome?, Am J Respir Crit Care Med, 198(11), 1459-1460, 20181201
  185. Conducting trials on corticosteroid dosing for respiratory failure in the last paradise., J Intensive Care., 6, 76-76, 20181120
  186. Comparison of extracorporeal membrane oxygenation outcome for influenza-associated acute respiratory failure in Japan between 2009 and 2016, JOURNAL OF INTENSIVE CARE, 6, 20180711
  187. Regional negative pressure pulmonary edema with pulmonary thromboembolism., Internal Medicine, 57(12), 1805-1806, 20180615
  188. Successful anesthetic management during abdominal wall-lifting laparoscopic cholecystectomy in a patient with hereditary angioedema, JA CLINICAL REPORTS, 4, 20180509
  189. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), JOURNAL OF INTENSIVE CARE, 6, 20180202
  190. ★, Implementation of an empirical antimicrobial protocol in a critical care setting: A single-center retrospective observational cohort study in bacteremic patients, JOURNAL OF INFECTION AND CHEMOTHERAPY, 24(12), 965-968, 201812
  191. Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia, JOURNAL OF ARTIFICIAL ORGANS, 21(4), 475-478, 201812
  192. Ventilator-associated events: prevalence and mortality in Japan, JOURNAL OF THORACIC DISEASE, 10(12), 6942-6949, 201812
  193. Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia., J Artif Organs., 21(4), 475-478, 201812
  194. Ventilator-associated events: prevalence and mortality in Japan., J Thorac Dis., 10(12), 6942-6949, 201812
  195. Focusing on Risk Factors of Cardiac Arrest During Intubation in ICU Again., Crit Care Med., 46(11), 1082-1082, 201811
  196. A survey on infection control in emergency departments in Japan, ACUTE MEDICINE & SURGERY, 5(4), 374-379, 201810
  197. Out-of-bed mobilization of patients undergoing mechanical ventilation with orotracheal tubes: A survey study, JOURNAL OF CRITICAL CARE, 47, 173-177, 201810
  198. An outbreak of fluoroquinolone-resistant Pseudomonas aeruginosa ST357 harboring the exoU gene, JOURNAL OF INFECTION AND CHEMOTHERAPY, 24(8), 615-622, 201808
  199. Oxygen management in mechanically ventilated patients: A multicenter prospective observational study, JOURNAL OF CRITICAL CARE, 46, 1-5, 201808
  200. ★, Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway, TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 245(3), 193-204, 201807
  201. Does Dysphagia After Extubation Really Increase Mortality?, Crit Care Med., 46(7), 726-727, 201807
  202. Committee of the Japan ECMO project. Comparison of extracorporeal membrane oxygenation outcome for influenza-associated acute respiratory failure in Japan between 2009 and 2016., J Intensive Care., 11(6), 38-38, 201807
  203. Committee for Infection Control for the Emergency Department, the Japanese Association for Acute Medicine, and the joint working group. A survey on infection control in emergency departments in Japan., Acute Med Surg., 5(4), 374-379, 201807
  204. Antimicrobials in the PICU: An Unresolved and Serious Matter., Pediatr Crit Care Med., 19(6), 581-582, 201806
  205. Pediatric sequential organ failure assessment score (pSOFA): a plea for the world-wide collaboration for consensus., Intensive Care Med., 44(6), 995-997, 201806
  206. Antimicrobials in the PICU: An Unresolved and Serious Matter., Pediatr Crit Care Med., 19(6), 581-582, 201806
  207. ★, Association between appropriate empiric antimicrobial therapy and mortality from bloodstream infections in the intensive care unit, JOURNAL OF INFECTION AND CHEMOTHERAPY, 24(4), 267-271, 201804
  208. Ultrasound-guided central venous catheter placement in children: what is a really good practice?, Intensive Care Med., 44(4), 546-547, 201804
  209. Target blood pressure for septic and vasodilatory shock: what is optimal?, Intensive Care Medicine, 44(4), 548-549, 201804
  210. Confounders for interpreting the benefit of a biomarker-based strategy in early discontinuation of empirical antifungal therapy., Intensive Care Med., 44(3), 399-400, 201803
  211. Memorable Experiencees of US Longterm Internship, Supported by Phoenix Leader Education Program., Anesthesia and Resuscitation., 53(4), 81-84, 201803
  212. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), ACUTE MEDICINE & SURGERY, 5(1), 3-89, 201801
  213. ★, Clinical outcomes after initial treatment of methicillin-resistant Staphylococcus aureus infections, INFECTION AND DRUG RESISTANCE, 11, 1073-1081, 2018
  214. Potential factors affecting lung inhomogeneity in acute respiratory distress syndrome., Intensive Care Med, 44(1), 125-126, 2018
  215. An emerging frontier in the treatment of acute exacerbation of idiopathic pulmonary fibrosis., Respir Investigation, 97-99, 2018
  216. Accurate quantification of pleural effusion and cofactors affecting weaning failure., Anesthesiology 3, 128, 678-679, 2018
  217. Is Oxygenation Really an Intrinsic Predictive Factor of Mortality in Patients Undergoing Extracorporeal Life Support?, Crit Care Med., 46(2), 181-182, 2018
  218. Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study, CRITICAL CARE, 21, 20171221
  219. Combined short- and long-axis ultrasound-guided central venous catheterization is superior to conventional techniques: A cross-over randomized controlled manikin trial, PLOS ONE, 12(12), 20171207
  220. Combined rupture of left ventricular free wall and pericardium, Intensive Care Medicine, 43(12), 1858-1859, 20171201
  221. Does enhanced antibiotic de-escalation really have no benefit in the ICU?, Critical Care, 21(1), 20171102
  222. Risk factors for sepsis-associated encephalopathy, Intensive Care Medicine, 43(10), 1548-1549, 20171001
  223. Is Higher Cerebral Oxygen Saturation Really Predictive of Favorable Neurologic Outcome after In-Hospital Cardiac Arrest?, Critical Care Medicine, 45(4), 468-469, 20170401
  224. Outcome prediction for acute respiratory distress syndrome: Are the current three variables really optimal?, Critical Care Medicine, 45(2), 237-238, 20170201
  225. Potential Confounders of the Accuracy and Reliability of Delirium Assessment Tools, Critical Care Medicine, 45(1), 114-114, 20170101
  226. The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines (second revised edition), Respiratory Investigation, 55(1), 83-92, 20170101
  227. New or Progressive Multiple Organ Dysfunction Syndrome in Pediatric Severe Sepsis: A Sepsis Phenotype With Higher Morbidity and Mortality, Pediatric Critical Care Medicine, 18(1), 8-16, 20170101
  228. Repetitive postoperative extubation failure and cardiac arrest due to laryngomalacia after general anesthesia in an elderly patient: a case report, JOURNAL OF ANESTHESIA, 31(5), 779-781, 201710
  229. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis, RESPIRATORY MEDICINE, 123, 105-109, 2017
  230. Pneumonia Severity Assessment Tools for Predicting Mortality in Patients with Healthcare-Associated Pneumonia: A Systematic Review and Meta-Analysis, RESPIRATION, 93(6), 441-450, 2017
  231. Proposal of a New Pediatric Sequential Organ Failure Assessment Score for Possible Validation, PEDIATRIC CRITICAL CARE MEDICINE, 18(1), 98-99, 2017
  232. Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 196(6), 795-796, 2017
  233. The role of source control in septic patients, Critical Care Medicine, 45(6), 618-619, 2017
  234. Optimal cutoff value for lung injury prediction score and potential confounders for identifying the risk of developing acute respiratory distress syndrome, Critical Care Medicine, 45(6), 624-625, 2017
  235. Successful long-term extracorporeal membrane oxygenation for invasive pulmonary aspergillosis: A case report, Journal of Medical Case Reports, 11(1), 2017
  236. Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis., Sci Rep., 6(38097), 20161207
  237. Pediatric cardiorespiratory failure successfully managed with venoarterial-venous extracorporeal membrane oxygenation: a case report, BMC PULMONARY MEDICINE, 16, 20160812
  238. ★, Early mobilization of mechanically ventilated patients in the intensive care unit, JOURNAL OF INTENSIVE CARE, 4, 20160729
  239. Potential covariates that affect post-extubation breathing effort in children., Intensive Care Med., 42(12), 2127-2128, 201612
  240. Factors affecting biomarkers of endothelial andalveolar epithelial dysfunction., Intensive Care Med., 42(12), 2111-2112, 201612
  241. Is transpulmonary pressure-guided PEEP titration really optimal?, Intensive Care Med., 42(11), 1845-1846, 201611
  242. Exploring Potential Cofactors Affecting Coagulation and Inflammation Activity During Extracorporeal Membrane Oxygenation., Crit Care Med., 44(11), e1149-e1150, 201611
  243. Successful treatment of traumatic spinal epidural haematoma with fluoroscopically-guided percutaneous drainage: a report of two cases, ANAESTHESIA AND INTENSIVE CARE, 44(6), 777-780, 201611
  244. Current rehabilitation practices in intensive care units: a preliminary survey by the Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group., J Intensive Care., 28(4), 66-66, 201610
  245. Is an Earlier and More Intensive Physical Therapy Program Better?, Am J Respir Crit Care Med., 194(8), 1032-1032, 201610
  246. Are probiotics actually useful in decreasing VAP rate?, Intensive Care Med., 42(10), 1643-1644, 201610
  247. Clinical and investigative critical care medicine in Japan., Intensive Care Med., 42(3), 453-455, 201603
  248. Emphysematous pancreatitis., Intensive Care Med., 42(6), 1075-1075, 2016
  249. Exploring Causative Pathology Is Essential for Validating Harmful Effects of Late Intubation., Crit Care Med, 44, e770-e771, 2016
  250. Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis, SCIENTIFIC REPORTS, 6, 2016
  251. Early mobilization of mechanically ventilated patients in the intensive care unit., J Intensive Care, 29(4), 50-50, 2016
  252. Clinical and investigative critical care medicine in Japan, INTENSIVE CARE MEDICINE, 42(3), 453-455, 2016
  253. Emphysematous pancreatitis, INTENSIVE CARE MEDICINE, 42(6), 1075-1075, 2016
  254. Exploring Causative Pathology Is Essential for Validating Harmful Effects of Late Intubation, CRITICAL CARE MEDICINE, 44(8), E770-E771, 2016
  255. Are probiotics actually useful in decreasing VAP rate?, INTENSIVE CARE MEDICINE, 42(10), 1643-1644, 2016
  256. Is an Earlier and More Intensive Physical Therapy Program Better?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 194(8), 1032-1032, 2016
  257. Is transpulmonary pressure-guided PEEP titration really optimal?, INTENSIVE CARE MEDICINE, 42(11), 1845-1846, 2016
  258. Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction, INTENSIVE CARE MEDICINE, 42(12), 2111-2112, 2016
  259. Potential covariates that affect post-extubation breathing effort in children, INTENSIVE CARE MEDICINE, 42(12), 2127-2128, 2016
  260. Exploring Potential Cofactors Affecting Coagulation and Inflammation Activity During Extracorporeal Membrane Oxygenation, CRITICAL CARE MEDICINE, 44(11), E1149-E1150, 2016
  261. Current rehabilitation practices in intensive care units: a preliminary survey by the Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group., J Intensive Care., 4(66), 2016
  262. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study., Am J Respir Crit Care Med., 191(10), 1147-1157, 20150515
  263. Innovation, Cost, and Sustainability of Pediatric Ventricular Assist Device Programs., Pediatr Crit Care Med., 16(6), 589-590, 201507
  264. A survey of the competency of ambulance service personnel in the diagnosis and management of sepsis., J Emerg Med, 49(2), 147-151, 2015
  265. Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study., Crit Care., 19, 325-325, 2015
  266. Ultrasound Imaging Reduces Failure Rates of Percutaneous Central Venous Catheterization in Children., Pediatr Crit Care Med., 16(8), 718-725, 2015
  267. Polymyxin B haemoperfusion in septic shock patients., Intensive Care Med., 41(11), 2033-2033, 2015
  268. Respiratory rate criteria for pediatric systematic inlammatory response syndrome, Pediatr Crit Care Med, 15(2), 182-182, 2014
  269. A novel method for ultrasound-guided radial arterial catheterization in pediatric patients, Anesth Analg, 118(5), 1019-1026, 2014
  270. Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome, BMJ Case Rep, 2014
  271. A pilot study of Bifidobacterium breve in neonates undergoing surgery for congenital heart disease, Journal of Intensive Care, 2(36), 2014
  272. Sepsis Registry Committee of The Japanese Society of intensive Care Medicine, Journal of Intensive Care, 2(55), 2014
  273. Emphysematous pancreatitis., Intensive care medicine, 42(6), 2016
  274. Clinical and investigative critical care medicine in Japan., Intensive care medicine, 42(3), 2016
  275. Exploring Causative Pathology Is Essential for Validating Harmful Effects of Late Intubation., Critical care medicine, 44(8), 2016
  276. Early mobilization of mechanically ventilated patients in the intensive care unit., Journal of intensive care, 4, 2016
  277. Pediatric cardiorespiratory failure successfully managed with venoarterial-venous extracorporeal membrane oxygenation: a case report., BMC pulmonary medicine, 16(1), 2016
  278. Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction., Intensive care medicine, 42(12), 2016
  279. Are probiotics actually useful in decreasing VAP rate?, Intensive care medicine, 42(10), 2016
  280. Is transpulmonary pressure-guided PEEP titration really optimal?, Intensive care medicine, 42(11), 2016
  281. Is an Earlier and More Intensive Physical Therapy Program Better?, American journal of respiratory and critical care medicine, 194(8), 2016
  282. Potential covariates that affect post-extubation breathing effort in children., Intensive care medicine, 42(12), 2016
  283. Exploring Potential Cofactors Affecting Coagulation and Inflammation Activity During Extracorporeal Membrane Oxygenation., Critical care medicine, 44(11), 2016
  284. Current rehabilitation practices in intensive care units: a preliminary survey by the Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group., Journal of intensive care, 4, 2016
  285. Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis., Scientific reports, 6, 2016
  286. Potential Confounders of the Accuracy and Reliability of Delirium Assessment Tools., Critical care medicine, 45(1), 2017
  287. Proposal of a New Pediatric Sequential Organ Failure Assessment Score for Possible Validation., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 18(1), 2017
  288. Outcome Prediction for Acute Respiratory Distress Syndrome: Are the Current Three Variables Really Optimal?, Critical care medicine, 45(2), 2017
  289. FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis., Respiratory medicine, 123, 2017
  290. Is Higher Cerebral Oxygen Saturation Really Predictive of Favorable Neurologic Outcome After In-Hospital Cardiac Arrest?, Critical care medicine, 45(4), 2017
  291. Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome., American journal of respiratory and critical care medicine, 196(6), 2017
  292. Repetitive postoperative extubation failure and cardiac arrest due to laryngomalacia after general anesthesia in an elderly patient: a case report., Journal of anesthesia, 31(5), 2017
  293. The Role of Source Control in Septic Patients., Critical care medicine, 45(6), 2017
  294. Optimal Cutoff Value for Lung Injury Prediction Score and Potential Confounders for Identifying the Risk of Developing Acute Respiratory Distress Syndrome., Critical care medicine, 45(6), 2017
  295. Risk factors for sepsis-associated encephalopathy., Intensive care medicine, 43(10), 2017
  296. Successful long-term extracorporeal membrane oxygenation for invasive pulmonary aspergillosis: a case report., Journal of medical case reports, 11(1), 2017
  297. Combined rupture of left ventricular free wall and pericardium., Intensive care medicine, 43(12), 2017
  298. Potential factors affecting lung inhomogeneity in acute respiratory distress syndrome., Intensive care medicine, 44(1), 2018
  299. Does enhanced antibiotic de-escalation really have no benefit in the ICU?, Critical care (London, England), 21(1), 2017
  300. Confounders Affecting the Prognosis in Patients With Acute Decompensated Heart Failure Who Underwent Extracorporeal Membrane Oxygenation., Critical care medicine, 45(12), 2017
  301. Potential Confounders of Procalcitonin-Guided Antibiotic Therapy for Sepsis., Critical care medicine, 45(12), 2017
  302. Combined short- and long-axis ultrasound-guided central venous catheterization is superior to conventional techniques: A cross-over randomized controlled manikin trial., PloS one, 12(12), 2017
  303. Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study., Critical care (London, England), 21(1), 2017
  304. Association between appropriate empiric antimicrobial therapy and mortality from bloodstream infections in the intensive care unit., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 24(4), 2018
  305. Is Oxygenation Really an Intrinsic Predictive Factor of Mortality in Patients Undergoing Extracorporeal Life Support?, Critical care medicine, 46(2), 2018
  306. Confounders for interpreting the benefit of a biomarker-based strategy in early discontinuation of empirical antifungal therapy., Intensive care medicine, 44(3), 2018
  307. Regional Negative Pressure Pulmonary Edema with Pulmonary Thromboembolism., Internal medicine (Tokyo, Japan), 57(12), 2018
  308. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)., Journal of intensive care, 6, 2018
  309. Accurate Quantification of Pleural Effusion and Cofactors Affecting Weaning Failure., Anesthesiology, 128(3), 2018
  310. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)., Acute medicine & surgery, 5(1), 2018
  311. Potential confounders affecting the reintubation rate : Discussion on "Reconnection to mechanical ventilation for 1 h after a successful spontaneous breathing trial reduces reintubation in critically ill patients: a multicenter randomized controlled trial"., Intensive care medicine, 44(4), 2018
  312. Tracheal injury detected immediately after median sternotomy by inexperienced surgeons: two case reports., Journal of medical case reports, 12(1), 2018
  313. Ultrasound-guided central venous catheter placement in children: what is a really good practice?, Intensive care medicine, 44(4), 2018
  314. Target blood pressure for septic and vasodilatory shock: what is optimal?, Intensive care medicine, 44(4), 2018
  315. An emerging frontier in the treatment of acute exacerbation of idiopathic pulmonary fibrosis., Respiratory investigation, 56(2), 2018
  316. An outbreak of fluoroquinolone-resistant Pseudomonas aeruginosa ST357 harboring the exoU gene., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 24(8), 2018
  317. Paediatric sequential organ failure assessment score (pSOFA): a plea for the world-wide collaboration for consensus., Intensive care medicine, 44(6), 2018
  318. Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia., Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 21(4), 2018
  319. Antimicrobials in the PICU: An Unresolved and Serious Matter., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 19(6), 2018
  320. Does Dysphagia After Extubation Really Increase Mortality?, Critical care medicine, 46(7), 2018
  321. Out-of-bed mobilization of patients undergoing mechanical ventilation with orotracheal tubes: A survey study., Journal of critical care, 47, 2018
  322. Comparison of extracorporeal membrane oxygenation outcome for influenza-associated acute respiratory failure in Japan between 2009 and 2016., Journal of intensive care, 6, 2018
  323. Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway., The Tohoku journal of experimental medicine, 245(3), 2018
  324. A Therapeutic Strategy for All Pneumonia Patients: A 3-Year Prospective Multicenter Cohort Study Using Risk Factors for Multidrug-resistant Pathogens to Select Initial Empiric Therapy., Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 68(7), 2019
  325. Clinical outcomes after initial treatment of methicillin-resistant Staphylococcus aureus infections., Infection and drug resistance, 11, 2018
  326. Should We Abandon Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome?, American journal of respiratory and critical care medicine, 198(11), 2018
  327. Transient severe distributive shock due to early dumping syndrome: a case report., Journal of medical case reports, 12(1), 2018
  328. Implementation of an empirical antimicrobial protocol in a critical care setting: A single-center retrospective observational cohort study in bacteremic patients., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 24(12), 2018
  329. Comparing Combined Short-Axis and Long-Axis Ultrasound-Guided Central Venous Catheterization With Conventional Short-Axis Out-of-Plane Approaches., Journal of cardiothoracic and vascular anesthesia, 33(4), 2019
  330. Focusing on Risk Factors of Cardiac Arrest During Intubation in ICU Again., Critical care medicine, 46(11), 2018
  331. A survey on infection control in emergency departments in Japan., Acute medicine & surgery, 5(4), 2018
  332. Conducting trials on corticosteroid dosing for respiratory failure in the last paradise., Journal of intensive care, 6, 2018
  333. The western Japan chaotic rainstorm disaster: a brief report from Hiroshima., Journal of intensive care, 6, 2018
  334. Dynamic Needle Tip Positioning for Ultrasound-Guided Arterial Catheterization in Infants and Small Children With Deep Arteries: A Randomized Controlled Trial., Journal of cardiothoracic and vascular anesthesia, 33(7), 2019
  335. Potential confounders for the effect of high-flow nasal cannula oxygen therapy., Critical care (London, England), 23(1), 2019
  336. Ventilator-associated events: prevalence and mortality in Japan., Journal of thoracic disease, 10(12), 2018
  337. High serum potassium level is associated with successful electrical cardioversion for new-onset atrial fibrillation in the intensive care unit: A retrospective observational study., Anaesthesia and intensive care, 47(1), 2019
  338. Comparison of three video laryngoscopes and direct laryngoscopy for emergency endotracheal intubation: a retrospective cohort study., BMJ open, 9(3), 2019
  339. ICU staffing models and patient outcomes., Journal of intensive care, 7, 2019
  340. Combined Approach Versus 2 Conventional Approaches in Ultrasound-Guided Central Venous Catheterization: A Randomized Controlled Trial., Journal of cardiothoracic and vascular anesthesia, 33(11), 2019
  341. Dynamic Needle Tip Positioning for Ultrasound-Guided Placement of a Peripherally Inserted Central Catheter in Pediatric Patients., Journal of cardiothoracic and vascular anesthesia, 34(1), 2020
  342. Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study., Journal of chemotherapy (Florence, Italy), 31(7-8), 2019
  343. Is lung ultrasonography really useful for diagnosing weaning-induced pulmonary oedema?, Intensive care medicine, 45(9), 2019
  344. Superiority of Dynamic Needle Tip Positioning for Ultrasound-Guided Peripheral Venous Catheterization in Patients Younger Than 2 Years Old: A Randomized Controlled Trial., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 20(9), 2019
  345. Decreased intracellular histamine concentration and basophil activation in anaphylaxis., Allergology international : official journal of the Japanese Society of Allergology, 69(1), 2020
  346. Comparison of video and conventional laryngoscopes for simulated difficult emergency tracheal intubations in the presence of liquids in the airway., PloS one, 14(7), 2019
  347. Ultrasonographic Detection of Micro-Bubbles in the Right Atrium to Confirm Peripheral Venous Catheter Position in Children., Critical care medicine, 47(10), 2019
  348. Does nasal high-flow preoxygenation really reduce intubation-related adverse events?, Intensive care medicine, 46(3), 2020
  349. Confounding factors for the effect of misdiagnosis of site of infection on in-hospital mortality., Critical care (London, England), 23(1), 2019
  350. Ceftolozane-tazobactam versus meropenem for treatment of nosocomial pneumonia (ASPECT-NP): a randomised, controlled, double-blind, phase 3, non-inferiority trial., The Lancet. Infectious diseases, 19(12), 2019
  351. Early Extubation for Infant Cardiac Surgery Supported by Dexmedetomidine Use., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 20(10), 2019
  352. Effect of pulsed xenon ultraviolet disinfection on methicillin-resistant Staphylococcus aureus contamination of high-touch surfaces in a Japanese hospital., American journal of infection control, 48(2), 2020
  353. Determination of the Appropriate Depth of Cuffed Endotracheal Tubes in Pediatric Intensive Care., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 20(11), 2019
  354. Unique patterns of lower respiratory tract microbiota are associated with inflammation and hospital mortality in acute respiratory distress syndrome., Respiratory research, 20(1), 2019
  355. The Volume of Pediatric Blood Culture., The Pediatric infectious disease journal, 38(12), 2019
  356. Baseline High-Resolution CT Findings Predict Acute Exacerbation of Idiopathic Pulmonary Fibrosis: German and Japanese Cohort Study., Journal of clinical medicine, 8(12), 2019
  357. Neurally adjusted ventilatory assist mitigates ventilator-induced diaphragm injury in rabbits., Respiratory research, 20(1), 2019
  358. Retrospective immunohistological study of autopsied lungs in patients with acute exacerbation of interstitial pneumonia managed with extracorporeal membrane oxygenation., Journal of thoracic disease, 11(11), 2019
  359. Potential Confounders for Applying a Novel Sepsis Care Quality Improvement Program., Critical care medicine, 48(2), 2020
  360. Successful anesthetic management during abdominal wall-lifting laparoscopic cholecystectomy in a patient with hereditary angioedema., JA clinical reports, 4(1), 2018
  361. Successful treatment of extensive spinal epidural abscess with fluoroscopy-guided percutaneous drainage: a case report., JA clinical reports, 6(1), 2020
  362. A Ruptured Mediastinal Bronchial Artery Aneurysm Treated with Urgent Thoracic Endovascular Aortic Repair., Internal medicine (Tokyo, Japan), 59(10), 2020
  363. Is Broad-Spectrum Antimicrobial Prophylaxis Ideal for Open-Chest Management?, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 21(3), 2020
  364. Further Investigation of Diagnostic Errors in Critically Ill Medical Patients., Critical care medicine, 48(5), 2020
  365. Impact of host- and early treatment-related factors on mortality in ICU patients with candidemia: a bicentric retrospective observational study., Journal of intensive care, 8, 2020
  366. Save the ICU and save lives during the COVID-19 pandemic., Journal of intensive care, 8, 2020
  367. Long-Axis In-Plane Approach Versus Short-Axis Out-of-Plane Approach for Ultrasound-Guided Central Venous Catheterization in Pediatric Patients: A Randomized Controlled Trial., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 21(11), 2020
  368. Esophageal pressure and potential confounders for evaluating patient-ventilator asynchrony., Journal of critical care, 60, 2020
  369. Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study., Journal of intensive care, 8, 2020
  370. Early PaCO2 Changes after Initiating Extracorporeal Membrane Oxygenation: Considerations for Future Research., American journal of respiratory and critical care medicine, 202(11), 2020
  371. Early Tracheostomy in Brain Injury: More Details Are Needed for Seeking Best Practice., Critical care medicine, 48(10), 2020
  372. Microglial translocator protein and stressor-related disorder., Neurochemistry international, 140, 2020
  373. Ultrasound-guided peripheral vascular catheterization in pediatric patients: a narrative review., Critical care (London, England), 24(1), 2020
  374. Better Management of Delirium by Family Members., Critical care medicine, 48(11), 2020
  375. Proteins produced by Streptococcus species in the lower respiratory tract can modify antiviral responses against influenza virus in respiratory epithelial cells., Microbes and infection, 23(1), 2021
  376. Prolonged versus intermittent β-lactam antibiotics intravenous infusion strategy in sepsis or septic shock patients: a systematic review with meta-analysis and trial sequential analysis of randomized trials., Journal of intensive care, 8, 2020
  377. Frequency and Risk Factors for Reverse Triggering in Pediatric Acute Respiratory Distress Syndrome during Synchronized Intermittent Mandatory Ventilation., Annals of the American Thoracic Society, 18(5), 2021
  378. Bent peripheral venous catheter inserted using ultrasound-guided dynamic needle tip positioning., The journal of vascular access, 23(1), 2022
  379. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model., Shock (Augusta, Ga.), 56(1), 2021
  380. Ultrasound-guided dynamic needle tip positioning versus conventional palpation approach for catheterisation of posterior tibial or dorsalis pedis artery in infants and small children., British journal of anaesthesia, 126(4), 2021
  381. Hypothermia, Poorly Recognized by clinicians, is associated with Higher Mortality Among Critically Ill Patients with infections: A Retrospective Observational Study., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 27(3), 2021
  382. Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study)., Journal of intensive care, 9(1), 2021
  383. A novel system that continuously visualizes and analyzes respiratory sounds to promptly evaluate upper airway abnormalities: a pilot study., Journal of clinical monitoring and computing, 36(1), 2022
  384. Combining pulsed xenon ultraviolet disinfection with terminal manual cleaning helps reduce the acquisition rate of methicillin-resistant Staphylococcus aureus., American journal of infection control, 49(8), 2021
  385. A machine-learning based approach to quantify fine crackles in the diagnosis of interstitial pneumonia: A proof-of-concept study., Medicine, 100(7), 2021
  386. Pediatric Fulminant Myocarditis in Japan: A Retrospective Nationwide Database Study of Hospital Volume, Management Practices, and Mortality., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 22(7), 2021
  387. Confounding Factors in a Study Investigating Mortality in Patients With Severe Hemoptysis., Critical care medicine, 49(4), 2021
  388. Unclear Benefit of Early Tracheostomy In Patients With Coronavirus Disease 2019., Critical care medicine, 49(7), 2021
  389. Post-extubation oxygenation strategies in acute respiratory failure: a systematic review and network meta-analysis., Critical care (London, England), 25(1), 2021
  390. Association of noninvasive respiratory support with mortality and intubation rates in acute respiratory failure: a systematic review and network meta-analysis., Journal of intensive care, 9(1), 2021
  391. Prevalence of rapid response systems in small hospitals: A questionnaire survey., Medicine, 100(23), 2021
  392. Japanese rapid/living recommendations on drug management for COVID-19., Acute medicine & surgery, 8(1), 2021
  393. Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial., Critical care (London, England), 25(1), 2021
  394. Patient-ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis., Journal of intensive care, 9(1), 2021
  395. Effect of region-wide use of prehospital stroke triage scale on management of patients with acute stroke., Journal of neurointerventional surgery, 14(7), 2022
  396. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)., Journal of intensive care, 9(1), 2021
  397. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)., Acute medicine & surgery, 8(1), 2021
  398. The Association between Wearing a Mask and COVID-19., International journal of environmental research and public health, 18(17), 2021
  399. The right care at the right place: Significance of intensive care units for critically ill patients., The Lancet regional health. Western Pacific, 13, 2021
  400. Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group., Critical care (London, England), 25(1), 2021
  401. Duration of infectious virus shedding in patients with severe coronavirus disease 2019 who required mechanical ventilation., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 28(1), 2022
  402. Did the Effect of the Guidelines eVAPorate? The Need for Improved Antimicrobial Stewardship Continues., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 22(10), 2021
  403. Identification of Aggravation-Predicting Gene Polymorphisms in Coronavirus Disease 2019 Patients Using a Candidate Gene Approach Associated With Multiple Phase Pathogenesis: A Study in a Japanese City of 1 Million People., Critical care explorations, 3(11), 2021
  404. Short- versus prolonged-course antibiotic therapy for sepsis or infectious diseases in critically ill adults: a systematic review and meta-analysis., Infectious diseases (London, England), 54(3), 2022
  405. Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (September 2021)., Acute medicine & surgery, 8(1), 2021
  406. Differential Effectiveness of Hypothermic Targeted Temperature Management According to the Severity of Post-Cardiac Arrest Syndrome., Journal of clinical medicine, 10(23), 2021
  407. Case Report: Emphysematous Pyelonephritis With a Congenital Giant Ureterocele., Frontiers in pediatrics, 9, 2021
  408. Concerning the Association Between Delayed Administration of Antibiotics and Mortality in Patients With Suspected Sepsis., Critical care medicine, 50(1), 2022
  409. Potential Confounders in Evaluating the Impact of Hyperoxia on Neurological Outcomes in Patients Receiving Extracorporeal Membrane Oxygenation., Critical care medicine, 50(1), 2022
  410. Real-time assessment of swallowing sound using an electronic stethoscope and an artificial intelligence system., Clinical and experimental dental research, 8(1), 2022
  411. Clinical and microbiological outcomes, by causative pathogen, in the ASPECT-NP randomized, controlled, Phase 3 trial comparing ceftolozane/tazobactam and meropenem for treatment of hospital-acquired/ventilator-associated bacterial pneumonia., The Journal of antimicrobial chemotherapy, 77(4), 2022
  412. Deep sedation predicts pressure injury in patients admitted to intensive care units., Nursing in critical care, 27(6), 2022
  413. Regional respiratory sound abnormalities in pneumothorax and pleural effusion detected via respiratory sound visualization and quantification: case report., Journal of clinical monitoring and computing, 36(6), 2022
  414. Neutralizing Type I Interferon Autoantibodies in Japanese Patients With Severe COVID-19., Research square, 2022
  415. Risk factors for peripheral intravascular catheter-related phlebitis in critically ill patients: analysis of 3429 catheters from 23 Japanese intensive care units., Annals of intensive care, 12(1), 2022
  416. Changes in pediatric intensive care unit cases due to the novel coronavirus., Pediatrics international : official journal of the Japan Pediatric Society, 64(1), 2022
  417. Resource-rich Intensive Care Units Improve Health-What Is Next?, JMA journal, 5(2), 2022
  418. The Current and Future State of Pediatric Sepsis Definitions: An International Survey., Pediatrics, 149(6), 2022
  419. Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out-of-Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry., Journal of the American Heart Association, 11(12), 2022
  420. Quantification of respiratory sounds by a continuous monitoring system can be used to predict complications after extubation: a pilot study., Journal of clinical monitoring and computing, 37(1), 2023
  421. ARDS clinical practice guideline 2021., Respiratory investigation, 60(4), 2022
  422. Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19., Journal of clinical immunology, 42(7), 2022
  423. ARDS Clinical Practice Guideline 2021., Journal of intensive care, 10(1), 2022
  424. Temporal trends of medical cost and cost-effectiveness in sepsis patients: a Japanese nationwide medical claims database., Journal of intensive care, 10(1), 2022
  425. Controversial Efficacy of Prone-Positioning for Patients With Severe Acute Respiratory Distress Syndrome Undergoing Venous-Venous Extracorporeal Membrane Oxygenation., Critical care medicine, 50(9), 2022
  426. Alarming of Severe Respiratory Failure Requiring ECMO Caused by the SARS-CoV-2 Omicron Variant., JMA journal, 5(3), 2022
  427. Combined short-axis out-of-plane and long-axis in-plane approach versus long-axis in-plane approach for ultrasound-guided central venous catheterization in infants and small children: A randomized controlled trial., PloS one, 17(9), 2022
  428. Incidence of catheter-related bloodstream infections following ultrasound-guided central venous catheterization: a systematic review and meta-analysis., BMC infectious diseases, 22(1), 2022
  429. The research environment of critical care in three Asian countries: A cross-sectional questionnaire survey., Frontiers in medicine, 9, 2022
  430. Japanese rapid/living recommendations on drug management for COVID-19: updated guidelines (July 2022)., Acute medicine & surgery, 9(1), 2022
  431. A burden of fluid, sodium, and chloride due to intravenous fluid therapy in patients with respiratory support: a post-hoc analysis of a multicenter cohort study., Annals of intensive care, 12(1), 2022
  432. Effect of wearing a surgical mask on short-term pulmonary gas exchange in patients immediately after anaesthesia., Indian journal of anaesthesia, 66(8), 2022
  433. Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study., Journal of intensive care, 10(1), 2022
  434. Trends in survival during the pandemic in patients with critical COVID-19 receiving mechanical ventilation with or without ECMO: analysis of the Japanese national registry data., Critical care (London, England), 26(1), 2022
  435. Unexpected cholinergic crisis caused by distigmine bromide: A case report., Medicine, 101(47), 2022
  436. An algorithm for PCT-guided antimicrobial therapy: a consensus statement by Japanese experts., Clinical chemistry and laboratory medicine, 61(3), 2023
  437. Risk factors for peripheral venous catheter-related phlebitis stratified by body mass index in critically ill patients: A post-hoc analysis of the AMOR-VENUS study., Frontiers in medicine, 9, 2022
  438. A study of the risk factors for phlebitis in patients stratified using the acute physiology and chronic health evaluation II score and admitted to the intensive care unit: A post hoc analysis of the AMOR-VENUS study., Frontiers in medicine, 9, 2022
  439. Mortality analysis among sepsis patients in and out of intensive care units using the Japanese nationwide medical claims database: a study by the Japan Sepsis Alliance study group., Journal of intensive care, 11(1), 2023
  440. GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL., Shock (Augusta, Ga.), 59(1), 2023
  441. Ultrasound-guided short-axis out-of-plane approach with or without dynamic needle tip positioning for arterial line insertion in children: A systematic review with network meta-analysis., Anaesthesia, critical care & pain medicine, 42(3), 2023
  442. Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department., Scientific reports, 13(1), 2023
  443. Temperature management using an intervascular cooling device for a COVID-19 patient with refractory hyperthermia., Clinical case reports, 11(4), 2023
  444. Lethal Interstitial Lung Disease Associated with a Gain-of-Function Mutation in IFIH1., Journal of clinical immunology, 43(6), 2023
  445. Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS., Respiratory research, 24(1), 2023
  446. Predictive Accuracy of the ROX Index for Re-Intubation in Mechanically Ventilated Patients With COVID-19., Respiratory care, 68(8), 2023
  447. Lung Abscess and Pyothorax in Critically Ill COVID-19 Patients: A Single-Center Retrospective Study., Critical care explorations, 5(5), 2023
  448. Is Pneumomediastinum Really an Independent Prognostic Factor for COVID-19 Pneumonia?, Critical care medicine, 51(6), 2023
  449. Ultrasound-Guided Short-Axis Out-of-Plane Approach With or Without Dynamic Needle-Tip Positioning for Peripheral Venous Catheterization in Pediatric Patients: A Systematic Review With Network Meta-Analysis., Journal of cardiothoracic and vascular anesthesia, 37(10), 2023
  450. Impact of the failure of initial insertion of a peripheral intravascular catheter on the development of adverse events in patients admitted to the intensive care unit from the emergency room: A post hoc analysis of the AMOR-VENUS study., Acute medicine & surgery, 10(1), 2023
  451. Controversial Efficacy of Early Timing of Prone Positioning for Severe Acute Respiratory Distress Syndrome During Venovenous Extracorporeal Membrane Oxygenation., Critical care medicine, 51(7), 2023
  452. Use of a laryngeal tube for sialolithotomy in a pediatric patient with left vocal cord paralysis: a case report., JA clinical reports, 9(1), 2023
  453. Beyond the unthinkable: Are we prepared for rare disasters?, Anaesthesia, critical care & pain medicine, 42(4), 2023
  454. Efficacy of perioperative prophylactic administration of corticosteroids in pediatric cardiac surgeries using cardiopulmonary bypass: a systematic review with meta-analysis., Anaesthesia, critical care & pain medicine, 42(6), 2023
  455. ICU Liberation Bundles and The Legend of Three Arrows., Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 24(8), 2023
  456. Comparison of radial, dorsalis pedis, and posterior tibial arteries for ultrasound-guided arterial catheterisation with dynamic needle tip positioning in paediatric patients: a randomised controlled trial., British journal of anaesthesia, 131(4), 2023
  457. Multisystem inflammatory syndrome in adults with COVID-19 requiring mechanical ventilation: A retrospective cohort study., Acute medicine & surgery, 10(1), 2023
  458. Survey of pediatric cardiovascular anesthesia in Japan., Journal of anesthesia, 38(2), 2024
  459. High versus low positive end-expiratory pressure setting in patients receiving veno-venous extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome: study protocol for the multicentre, randomised ExPress SAVER Trial., BMJ open, 13(10), 2023
  460. Usefulness of Quantification and Serial Monitoring of Fine Crackles for Early Detection of Treatment-related Lung Injury: A Report of Two Cases., Internal medicine (Tokyo, Japan), 63(12), 2024
  461. Usefulness of new acoustic respiratory sound monitoring with artificial intelligence for upper airway assessment in obese patients during monitored anesthesia care., The journal of medical investigation : JMI, 70(3.4), 2023
  462. New acoustic monitoring system quantifying aspiration risk during monitored anaesthesia care., Scientific reports, 13(1), 2023
  463. A Successful Prevention of Reintubation Using the Mechanical Insufflation-Exsufflation in a Critically Ill Patient With Impaired Airway Mucus Expectoration: A Case Report., Cureus, 15(10), 2023
  464. Association between hospital volume and in-hospital mortality in pediatric severe traumatic brain injury: a nationwide retrospective observational study in Japan., Journal of neurosurgery. Pediatrics, 33(2), 2024
  465. Efficiency and workload reduction of semi-automated citation screening software for creating clinical practice guidelines: a prospective observational study., Journal of epidemiology, 2023
  466. Prediction of the neurological outcomes post-cardiac arrest: A prospective validation of the CAST and rCAST., The American journal of emergency medicine, 75, 2024
  467. Association between hospital spending and in-hospital mortality of patients with sepsis based on a Japanese nationwide medical claims database study., Heliyon, 10(1), 2024
  468. Carbapenem vs. non-carbapenem antibiotics for ventilator-associated pneumonia: A systematic review with meta-analysis., Respiratory investigation, 62(2), 2024
  469. Time to Reexamine the Definition of Sepsis?, Critical care medicine, 52(2), 2024
  470. Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry., Journal of intensive care, 12(1), 2024
  471. Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study., Journal of intensive care, 12(1), 2024
  472. Epidemiology and patterns of empiric antimicrobial therapy practice in patients with community-onset sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group., IJID regions, 10, 2024
  473. External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study., Scientific reports, 14(1), 2024
  474. Bacterial profiles detected in ventilator-associated pneumonia in Japan: A systematic review., Respiratory investigation, 62(3), 2024
  475. Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest., Medicina (Kaunas, Lithuania), 60(3), 2024
  476. The Current Discussion Regarding End-of-Life Care for Patients with Out-of-Hospital Cardiac Arrest with Initial Non-Shockable Rhythm: A Narrative Review., Medicina (Kaunas, Lithuania), 60(4), 2024
  477. Genomic characterization of Staphylococcus aureus isolated from patients admitted to intensive care units of a tertiary care hospital: epidemiological risk of nasal carriage of virulent clone during admission., Microbiology spectrum, 12(6), 2024
  478. Hypercalcemic Crisis Complicated With Acute Respiratory Distress Syndrome Due to Hot Spring Drowning: A Case Report., Cureus, 16(4), 2024
  479. Incidence and mortality of community-acquired and nosocomial infections in Japan: a nationwide medical claims database study., BMC infectious diseases, 24(1), 2024
  480. Hospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation., Journal of intensive care, 12(1), 2024
  481. No improvement in mortality among critically ill patients with carbapenems as initial empirical therapy and more detection of multi-drug resistant pathogens associated with longer use: a post hoc analysis of a prospective cohort study., Microbiology spectrum, 2024

Publications such as books

  1. 2016, Critical Care UPDATE, 2016, Single work, 日本語
  2. 2015, Critical Care UPDATE, 2015, Single work, 日本語
  3. 2015, Critical Care UPDATE, 2015, Single work, 日本語

Awards

  1. Paul dudley whiteinternational scholar award, American heart assocaition, Highest ranked abstract from Japan at at the Resuscitation Science Symposium 2023
  2. 2022/07/03, Joint Congress Award of the 1st Joint Scientific Congress of TSCCM, TSECCM and JSICM Congress, Taiwan Society of Critical Care Medicine. Taiwan Society of Emergency and Critical Care Medicine, Chair of the Excecutive Board of the Japanese Society of Intensive Care Medicine, Prognostic analysis of patients with severe COVID-19 receiving mechanical ventilation with or without ECMO: An interim analysis of Japan national registry
  3. 2021/09/01, World congress of Anaesthesiologists 2021 BEST200, 17th World Congress of Anaesthesiologists, European Accreditation Council for Continuing Medical Educcation, Preventing bronchial intubation in children using a computer-assisted auscultation system

External Funds

Acceptance Results of Competitive Funds

  1. Research Program on Emerging and Re-emerging Infectious Diseases, 2022/04/01, 2023/03/31
  2. 2021, 2022
  3. 2011, 2014
  4. 2012, 2016
  5. 2014, 2014
  6. 2017, 2019
  7. 2017, 2019
  8. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2017, 2019
  9. 2017/.4, 2018/.3
  10. 2017/.6
  11. Development of Medical Devices and Systems for Advanced Medical Services , 2017/08/01, 2018/03/31
  12. Development of Medical Devices and Systems for Advanced Medical Services , 2018/04/01, 2019/03/31
  13. Development of Medical Devices and Systems for Advanced Medical Services, Development of Medical Devices and Systems for Advanced Medical Services, 2019, 2019
  14. 2019, 2020
  15. Acceleration Transformative Research for Medical Innovation, 2019/04/01, 2020/03/31
  16. 2020, 2020
  17. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2020, 2023
  18. Acceleration Transformative Research for Medical Innovation, 2020/04/01, 2021/09/30
  19. 2020, 2021
  20. Development of Medical Devices and Systems for Advanced Medical Services, Development of Medical Devices and Systems for Advanced Medical Services, 2020, 2020

Social Activities

Organizing Academic Conferences, etc.

  1. 2023/03, 2023/03
  2. INTERNATIONAL SERIAL VIRTUAL WEBINAR MANAGEMENT OF COVID-19 PATIENTS IN JAPAN AND VIETNAM, Chair, 2021/11, 2021/11
  3. 2020/12, 2020/12
  4. 2018/12, 2018/12
  5. 2018/05, 2018/05
  6. 2018/10, 2018/10
  7. 2017/06, 2017/06
  8. 2016/06, 2016/06
  9. 2017/05, 2017/05
  10. 2016/09, 2016/09

Other Social Contributions

  1. ECMO simulation labo., ECMO simulation labo., NPO ECMO JAPAN, 2019/08/31, 2019/09/01, Planner, Seminar or workshop, Scientific organization
  2. ECMO simulation labo., ECMO simulation labo., NPO ECMO JAPAN, 2017/05/27, 2017/05/28, Planner, Seminar or workshop, Scientific organization
  3. PALS provider course, PALS provider course, JIPICC, 2019/08/17, 2019/08/18, Planner, Seminar or workshop, Scientific organization

History as Peer Reviews of Academic Papers

  1. 2023, Respiratory Investigation, 1
  2. 2023, J cardiothorac surg, 1
  3. 2022, J of Pediatric Nursing, Others, 1
  4. 2023, BJA, Others, 1
  5. 2022, Internal Medicine, 1
  6. 2022, Medical Communication, Others, 1
  7. 2022, J of Pediatric Intensive Care, Others, 1
  8. 2021, British Journal of Anaesthesia, Others, 1
  9. 2021, Journal of Pediatric Intensive Care, Others, 1
  10. 2021, The Journal of Medical Investigation, Others, 1
  11. 2021, J of Perinatoloigy, Others, 1
  12. 2021, Frontiers in Medicine, Others, 1
  13. 2021, Clinical Infectious Disease, Others, 1
  14. 2021, BMJ case reports, Others, 2
  15. 2021, Japanese Medical Association Journal, Others, 1
  16. 2021, Scandinavian J of Trauma and Resuscitation, Others, 1
  17. 2021, J of Thoracic Disease, Others, 1
  18. 2020, International Journal of Infectious Diseases, 1
  19. 2020, Acute Medicine & Surgery, 4
  20. 2020, BMJ open, 2
  21. 2020, Cardiovascular Diagnosis and Therapy, 1
  22. 2020, Journal of International Medical Research, Others, 1
  23. 2020, Journal of Japanese Association for Acute Medicine, 4
  24. Journal of Japanese Society of Emergency Pediatrics, 2
  25. 2020, J of Artificial Organs, 2
  26. Liver International, 1
  27. 2020, Pediatrics International, 1
  28. 2020, Respiratory Medicine Case Reports, 4
  29. 2020, The Lancet Regional health western pacific, 1
  30. 2020, J Clinical Microbiology, Others, 1
  31. 2020, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2
  32. 2020, J of Infection and Chemotherapy, 6
  33. 2020, Pediatric Critical Care Medicine, Editor, Associate Editor, 14
  34. 2020, J Intensive Care, Editor, 14
  35. 2019, Infect Drug Resist, 3
  36. Pros One, Others, 1
  37. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Others, 1
  38. 2019, Clinical Interventions in Aging, Others, 1
  39. 2019, Pedaitr Crit Care Med, Editor, 11
  40. 2019, J Intensive care, Editor, 5
  41. 2018, J of Artif Organs, Others, 2
  42. 2018, J Antimicrobial Chemother, 1
  43. 2018, Med Sci Monitoring, Others, 1
  44. 2018, Int J Infect Dis, Others, 1
  45. 2018, Clinical epidemiology, Others, 1
  46. 2018, BMC pediatrics, Others, 1
  47. 2018, J Infect Chemother, Others, 4
  48. 2018, Pediatr Crit Care Med, Editor, 11
  49. 2018, J intensive care, Others, Deputy Editor, 15
  50. 2017, Acute Medicine and Surgery, Others, 1
  51. 2017, BMC pediatrics, Others, 1
  52. 2017, European Respiratory Reviews, Others, 1
  53. 2017, BMC Anesthesiology, Others, 1
  54. 2017, J Artif Organs, Others, 1
  55. 2017, Pulsus Journals, Others, 1
  56. 2017, Geriatrics Gentontology, Others, 1
  57. 2017, J Antimicrobial Chemother, Others, 1
  58. 2017, J of Infection and Chemotherapy, Others, 2
  59. 2017, J of Anesthesia, Others, 5
  60. 2017, Pediatr Crit Care Med, Editor, 16
  61. 2017, Pediatrics International, Editor, 9
  62. 2017, Journal of Intensive Care, Editor, 4
  63. 2016, Internal Medicine, Others, 1
  64. 2016, Journal of Cirtical Care, Others, 1
  65. 2016, Hospital practice, Others, 1
  66. 2016, Respiratory Medicine Case Reports, Others, 1
  67. 2016, BMC Anesthesiology, Others, 1
  68. 2016, Journal of Anesthesia, Others, 3
  69. 2016, Pediatrics international, Editor, 10
  70. 2016, Journal of Infection and Chemotherapy, Editor, 2
  71. 2016, Pediatric Critical Care Medicine, Editor, 12
  72. 2016, Journal of Intensive Care, Editor, 6
  73. 2015, Circulation Journal, Others, Reviewer, 1
  74. 2015, Hospital Practice, Others, Reviewer, 1
  75. 2015, Journal of Infection and Chemotherapy, Reviewer, 4
  76. 2015, Journal of Anesthesia, Editor, Reviewer, 4
  77. 2015, Journal of Japanese Society of Intensive Care Medicine, Others, Reviewer, 2
  78. 2015, Journal of Japanese Sciety of Surgical Infection, Editor, Editor, 4
  79. 2015, Journal of Intensive Care, Editor, Reviewer, 17
  80. 2015, Journal of Intensive Care, Editor, Associate Editor, 4
  81. 2015, Pediatrics International, Editor, Editor, 71
  82. 2015, Pediatric Critical Care Medicine, Editor, Associate Editor, 15
  83. 2015, Pediatrics International, Others, Reviewer, 2
  84. 2021, J Intensive Care, Editor, Deputy Editor, 141
  85. 2021, Acute Medicine & Surgery, 2
  86. 2021, J of Anesthesia, Others, 1
  87. 2021, Pediatric Critical Care Medicine, Editor, Associate Editor, 1
  88. 2021, Journal of Infection and Chemotherapy, Editor, 1
  89. 2021, BMC pediatrics, Others, 1
  90. 2021, International Journal of Infectious Diseases, Others, 3
  91. 2021, BMJ open, Others, 1
  92. 2021, Infect Drug Resist, Others, 1
  93. 2021, INTENSIVIST, Editor, 1
  94. 2022, INTENSIVIST, Editor, 2
  95. 2022, British Journal of Anaesthesia, Others, 1
  96. 2022, International Journal of Infectious Diseases, Others, 1
  97. 2022, BMC pediatrics, Others, 1
  98. 2022, Pediatric Critical Care Medicine, Editor, Associate Editor, 6
  99. 2022, J Intensive Care, Editor, Deputy Editor, 222
  100. 2022, Scandinavian J of Trauma and Resuscitation and Emergency Medicine, Others, 1
  101. 2023, J Intensive Care, Chief editor, Deputy Editor, 238