THANUTCHAPORN KUMRUNGSEE

Last Updated :2021/05/11

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
Web Site
E-mail
kumrunghiroshima-u.ac.jp
Self-introduction
My research interests are in elucidation of food factors with potent preventive effects on lifestyle-related diseases and their mechanisms. Currently, I am interested in exploring roles of imidazole dipeptides in muscle regeneration and brain functions as well as focusing on regulation of GABA metabolism to prevent obesity.

Basic Information

Major Professional Backgrounds

  • 2016/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphete Sciences, Assistant Professor
  • 2015/10/01, 2016/03/31, Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Postdoctoral researcher
  • 2019/04/01, 2020/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2019/06/04, 2019/08/28, McMaster University, Canada, Faculty of Health Sciences, Visiting professor
  • 2020/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor

Educational Backgrounds

  • Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Food Science and Biotechnology, 2012/10, 2015/09
  • Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Food Science and Biotechnology, 2010/10, 2012/09
  • Kasetsart University, Departmnet of Food Science and Technology, Food Science and Technology, Thailand, 2004/05, 2009/03

Academic Degrees

  • Kyushu University

Educational Activity

  • 【Bachelor Degree Program】School of Applied Biological Science : Department of Applied Biological Science
  • 【Master's Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • 【Doctoral Program】Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science Program

Research Fields

  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords


  • Skeletal muscle
    Muscle stem cells (satellite cells)
    Muscle regeneration
    functional foods
    bioactive compounds
    Carnosine/Homocarnosine
    vitamin B6

Affiliated Academic Societies

  • American Society for Nutrition, 2020/02
  • Japan Society of Nutrition and Food Science, 2016
  • The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), 2017
  • American Physiological Society, 2019/09

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 2Term, Life, food, and environmental sciences
  2. 2021, Liberal Arts Education Program1, 3Term, Food safety and health science
  3. 2021, Undergraduate Education, 2Term, Introduction to Applied Biological Science I
  4. 2021, Undergraduate Education, Intensive, Laboratory work in nutritional biochemistry
  5. 2021, Undergraduate Education, 1Term, Food Function (Functional Food Science)
  6. 2021, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  7. 2021, Undergraduate Education, 3Term, Modern Food Science
  8. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  9. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  10. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  11. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  12. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  13. 2021, Graduate Education (Master's Program) , 4Term, Nutrition and Food Functions II

Research Activities

Academic Papers

  1. Mungbean seed coat water extract inhibits inflammation in LPSinduced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IjBa/NF-jB, Journal of Food Science and Technology, 57(7), 2659-2668, 202007
  2. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles, AMINO ACIDS, 52(5), 743-753, 202005
  3. The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, SCIENTIFIC REPORTS, 9, 20191001
  4. Novel metabolic disturbances in marginal vitamin B-6-deficient rat heart, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 65, 26-34, 201903
  5. Feeding Aspergillus protease preparation combined with adequate protein diet to rats increases levels of cecum gut-protective amino acids, partially linked to Bifidobacterium and Lactobacillus, Bioscience, Biotechnology, and Biochemistry, 83(10), 1901-1911, 20190611
  6. Consumption of Low-Dose of Ethanol Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Rats, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 65(5), 443-450, 2019
  7. High-dose D-glucosamine Consumption Increases Serum and Cecum Levels of Ammonia and Ethanol and Causes Bacterial Overgrowth in Rats, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 25(1), 107-113, 201901
  8. GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 316(2), C162-C174, 201902
  9. Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases, Molecular Nutrition: Vitamins, 283-299, 201901
  10. Beneficial Effects of Dietary Tempeh Prepared with Rhizopus stolonifer on Liver Function in Rats Fed with a High-Fat Diet, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 64(5), 379-383, 2018
  11. Increased intestinal ethanol following consumption of fructooligosaccharides in rats, BIOMEDICAL REPORTS, 9(5), 427-432, 201811
  12. Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(9), 1796-1804, 2017
  13. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, JOURNAL OF FUNCTIONAL FOODS, 49, 162-167, 201810
  14. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, Journal of Functional Foods, 49, 162-167, 201810
  15. Production of Isoflavone Aglycone-enriched Tempeh with Rhizopus stolonifer, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 24(3), 493-499, 201803
  16. Gender Difference and Dietary Supplemental Vitamin B-6: Impact on Colon Luminal Environment, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 64(2), 116-128, 2018
  17. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23(3), 136-145, 201803
  18. Rice bran wax oleogel: A potential margarine replacement and its digestibility effect in rats fed a high-fat diet, JOURNAL OF FUNCTIONAL FOODS, 39, 250-256, 201712
  19. Consumption of an acid protease derived from Aspergillus oryzae causes bifidogenic effect in rats, NUTRITION RESEARCH, 44, 60-66, 2017
  20. TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(11), 2164-2167, 2017
  21. Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury, LIFE SCIENCES, 184, 103-111, 20170901
  22. Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity, Food Chemistry, 213, 329-335, 20161215
  23. Vasorelaxant effect of 5'-methylthioadenosine obtained from Candida utilis yeast extract through the suppression of intracellular Ca2+ concentration in rat isolated aorta, Journal of Agricultural and Food Chemistry, In Press, 2016
  24. Elution profile of di-peptides on a sulfonated ethylstyrene-divinylbenzene copolymer resin column by high-performance liquid chromatography, Analytical Sciences, 31, 45-50, 20150110
  25. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells, Food Chemistry, 152, 218-224, 2014
  26. ★, Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses, Biochimica et Biophysica Acta- General Subjects, 1840, 3073-3078, 2014

Publications such as books

  1. 2017/11, Science within Food: Up-to-date Advances on Research and Educational Ideas, Vitamin B6: a heart-protective molecule through a novel mechanism of increasing histidine-related compounds, vitamin B6; histidine-related compounds; carnosine; histamine; heart; cardiovascular disease, Formatex Research Center, 2017, November, Scholarly Book, Single work, E, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Norihisa Kato, Noriyuki Yanaka and Hong C. Lai, 978-84-947512-1-9, 299
  2. 2018/01/30, Advances in Industrial Applications of Yeasts, Koji-molds, and Lactic Acid Bacteria, 2018, January, Textbook, J, 加藤範久, 楊 永寿, Kumrungsee T, 978-4-7813-1317-7, 264

Invited Lecture, Oral Presentation, Poster Presentation

  1. A new muscle atrophy model, GDE5 transgenic mice, for searching for food factors preventing sarcopenia, Takumi KOMARU, Kanako SATO, Noriyuki YANAKA, Thanutchaporn KUMRUNGSEE, The 53rd Japan Society of Nutrition and Food Science China-Shikoku Branch Conference (held online), 2020/10, Without Invitation, Japanese
  2. Muscle regeneration ability and satellite cell content in a new muscle atrophy model, GDE5 transgenic mice, Takumi KOMARU, Kanako SATO, Noriyuki YANAKA, Thanutchaporn KUMRUNGSEE, The 57th Japan Society for Bioscience and Biotechnology 2020 Chugoku-Shikoku Branch Conference, 2020/09, Without Invitation, Japanese
  3. Vitamin B6 deficiency reduces satellite cell number in mouse skeletal muscle fibers, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Norihisa Kato, Noriyuki Yanaka, The 74th Annual Meeting of Japan Society of Nutrition and Food Science, 2020/05, Without Invitation, Japanese, Tohoku University, Sendai International Center, Sendai
  4. The potential roles of vitamin B6 in satellite cell functions, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Noriyuki Yanaka, The 2020 annual meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry, 2020/03, Without Invitation, Japanese, Kyushu University, Fukuoka
  5. We are in the age when banana, chocolate, and steak may disappear, 1. Thanutchaporn Kumrungsee, INU Student Seminar on Global Citizenship and Peace, 2018/08/10, With Invitation, English, Hiroshima University, Hiroshima University
  6. Vitamin B6 deficiency impairs imidazole homeostasis and energy metabolism in rat heart, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, Norihisa Kato, Nutrition 2018, 2018/06/09, Without Invitation, English, American Society of Nutrition, Boston, MA, USA
  7. Agriculture and Food Innovation: Functional foods as value-added agricultural products for health promotion, Thanutchaporn Kumrungsee, Triple Helix International Seminar: Linking University-Industry-Government, 2018/03/07, With Invitation, English, . University of Guanajuato, Guanajuato, Mexico
  8. Why is vitamin B6 important for your heart and skeletal muscle?, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 2018/03/05, With Invitation, English, Tianjin University of Science and Technology, Tianjin, China, Tianjin University of Science and Technology, Tianjin, China
  9. Vitamin B6: an underestimated compound regulating homeostasis of heart-protective peptides., Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, Norihisa Kato., The First International Conference of “Innovation of Functional Foods in Asia (IFFA), 2018/01/22, Without Invitation, English, Phayao, Thailand
  10. A possible novel mechanism underlying heart-protective effects of vitamin B6, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 46th Annual Meeting of Food and Agriculture Panel United States-Japan Cooperative Program in Natural Resources (UJNR), 2017/11/11, With Invitation, English, Hiroshima, Japan
  11. Decreased levels of putative heart protective metabolites in heart tissues of rats fed a vitamin B6 deficient diet: a metabolomics approach, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 22nd International Conference of Functional Food Center, 2017/09/22, Without Invitation, English, Boston, MA, USA
  12. Challenging of finding a new type of calmodulin inhibitors, Thanutchaporn Kumrungsee, Noriyuki Yanaka, 22nd International Conference of Functional Food Center, 2017/09/22, Without Invitation, English, Boston, MA, USA
  13. Histidine-related compounds as possible key mediators underlying a heart-protective effect of vitamin B6, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Norihisa Kato, International Congress on Carnosine and Anserine, 2017/09/12, Without Invitation, English, Louisville, KY, USA
  14. Vitamin B6: A heart protective molecule through a novel mechanism, Thanutchaporn Kumrungsee, 2017 年度(第21回)生物機能研究会, 2017/06/17, With Invitation, English, Hiroshima University, Higashi-shiroshima
  15. フラクトオリゴ糖摂取ラットの大腸内容物、及 び組織のエタノールの増加, Thanutchaporn Kumrungsee、山口 将大 、 Yongshou Yang、加藤 範久, The 71st Annual Meeting of the Japan Society of Nutrition and Food Science, 2017/05/19, Without Invitation, Japanese, The Japan Society of Nutrition and Food Science, Ginowann city, Okinawa
  16. Calmodulin-dependent protein kinase II inhibitory compounds derived from foodstuffs and their possible role in vascular protection, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, BIT 5th Annual World Congress of Food and Nutrition, 2016/11/18, Without Invitation, English, BIT Congress, Kaohsiung, Taiwan
  17. Bioactive compounds in yeast extract and their role in the regulation of blood vessel contraction, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, The Food Factor I Barcelona Conference, 2016/11/02, Without Invitation, English, Formatex Research Center, Barcelona, Spain
  18. Novel active peptides derived from wheat germ hydrolysate as putative nutraceuticals preventing calmodulin-dependent protein kinase II associated diseases, Thanutchaporn Kumrungsee, Toshiro Matsui, Norihisa Kato, 17th International Nutrition & Diagnostics Conference, 2016/10/03, Without Invitation, English, Institute of Nutrition and Diagnostics Pardubice, Prague, Czech Republic
  19. Novel food-derive compounds as potent nutraceuticals for preventing vascular-related diseases, Thanutchaporn KUMRUNGSEE, 2016/07/21, With Invitation, English, Faculty of Agro-Industry, Department of Food Science and Technology, Kasetsart University, Faculty of Agro-Industry, Department of Food Science and Technology, Kasetsart University, Thailand
  20. A novel bioactive compound derived from yeast extract as a potent nutraceutical for preventing vascular-related diseases, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, 2nd International Conference on Nutraceuticals and Nutrition Supplements, 2016/07/18, Without Invitation, English, Conference Series LLC, Bangkok, Thailand
  21. Food factors for health promotion and disease prevention, Thanutchaporn KUMRUNGSEE, 生物圏科学研究科セミナー, 2016/07/11, With Invitation, English, Graduate School of Biosphere Science, Hiroshima University, Graduate School of Biosphere Science, Hiroshima University

Awards

  1. 2019/11/04, Young Investigator Award (to Kanako Sato, Master student), The 7th International Conference on Food Factors, gamma-Aminobutyric acid induces biosynthesis of a novel imidazole peptide in skeletal muscle
  2. 2016/07/18, Phenomenal and worthy oral presentation, 2nd International Conference on Nutraceuticals and Nutrition Supplements, A novel bioactive compound derived from yeast extract as a potent nutraceutical for preventing vascular-related diseases

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2020
  2. Hiroshima University Grant for Female Scholars’ International Collaborative Research , 2018/11/01, 2019/09/30