THANUTCHAPORN KUMRUNGSEE

Last Updated :2022/11/01

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
Web Site
E-mail
kumrunghiroshima-u.ac.jp
Self-introduction
My research interests are in elucidation of food factors with potent preventive effects on lifestyle-related diseases and their mechanisms. Currently, I am interested in exploring roles of imidazole dipeptides in muscle regeneration and brain functions as well as focusing on regulation of GABA metabolism to prevent obesity.

Basic Information

Major Professional Backgrounds

  • 2020/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor
  • 2019/06/04, 2019/08/28, McMaster University, Canada, Faculty of Health Sciences, Visiting professor
  • 2019/04/01, 2020/03/31, Hiroshima University, Graduate School of Integrated Sciences for Life, Assistant Professor
  • 2016/04/01, 2019/03/31, Hiroshima University, Graduate School of Biosphere Sciences, Assistant Professor
  • 2015/10/01, 2016/03/31, Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Postdoctoral researcher

Educational Backgrounds

  • Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Food Science and Biotechnology, 2012/10, 2015/09
  • Kyushu University, Graduate School of Bioresource and Bioenvironmental Sciences, Food Science and Biotechnology, 2010/10, 2012/09
  • Kasetsart University, Departmnet of Food Science and Technology, Food Science and Technology, Thailand, 2004/05, 2009/03

Academic Degrees

  • Ph.D, Kyushu University

Educational Activity

  • [Bachelor Degree Program] School of Applied Biological Science : Department of Applied Biological Science : Food Science Program
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Food and AgriLife Science

In Charge of Primary Major Programs

  • Food Science Program

Research Fields

  • Agricultural sciences;Agricultural chemistry;Food science

Research Keywords


  • skeletal muscle
    muscle stem cells (satellite cells)
    muscle regeneration
    functional foods
    bioactive compounds
    carnosine/Homocarnosine
    obesity
    GABA
    vitamin B6

Affiliated Academic Societies

  • The Society of Japanese Women Scientists (SJWS), 2020/10
  • American Society for Nutrition, 2020/02
  • Japan Society of Nutrition and Food Science, 2016
  • The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), 2017
  • American Physiological Society, 2019/09

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 4Term, Food and Life Science
  2. 2022, Liberal Arts Education Program1, 3Term, Food safety and health science
  3. 2022, Undergraduate Education, 4Term, Introduction to Applied Biological Science II
  4. 2022, Undergraduate Education, Second Semester, Graduation Thesis I
  5. 2022, Undergraduate Education, First Semester, Graduation Thesis II
  6. 2022, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  7. 2022, Undergraduate Education, Intensive, Laboratory work in nutritional biochemistry
  8. 2022, Undergraduate Education, 1Term, Food Function (Functional Food Science)
  9. 2022, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  10. 2022, Undergraduate Education, 3Term, Modern Food Science
  11. 2022, Undergraduate Education, 3Term, Molecular-Level Understanding of Functionality of Foods
  12. 2022, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
  13. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  14. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  15. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  16. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  17. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  18. 2022, Graduate Education (Master's Program) , 4Term, Nutrition and Food Functions II

Research Activities

Academic Papers

  1. Aspergillus-Derived Cellulase Preparation Exhibits Prebiotic-like Effects on Gut Microbiota in Rats, Fermentation, 8(2), 202202
  2. Satellite cell content and muscle regeneration in a mouse model of NAFLD, Nutrition, 96, 202204
  3. Serum Amyloid A3 Promoter-Driven Luciferase Activity Enables Visualization of Diabetic Kidney Disease, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2), 202201
  4. Emerging cardioprotective mechanisms of vitamin B6: a narrative review, EUROPEAN JOURNAL OF NUTRITION, 61(2), 605-613, 202203
  5. Comparative study on molecular mechanism of diabetic myopathy in two different types of streptozotocin-induced diabetic models, LIFE SCIENCES, 288, 20220101
  6. Satellite Cells Exhibit Decreased Numbers and Impaired Functions on Single Myofibers Isolated from Vitamin B6-Deficient Mice, NUTRIENTS, 13(12), 202112
  7. Dietary GABA and its combination with vigabatrin mimic calorie restriction and induce antiobesity-like effects in lean mice, JOURNAL OF FUNCTIONAL FOODS, 78, 202103
  8. Supplemental Aspergillus Lipase and Protease Preparations Display Powerful Bifidogenic Effects and Modulate the Gut Microbiota Community of Rats, FERMENTATION-BASEL, 7(4), 202112
  9. Fermented date residue extract mix containing gamma-aminobutyric acid augments the immune function of mouse splenocytes, Bioscience, Biotechnology, and Biochemistry, 85(7), 1753-1758, 20210524
  10. Liver choline metabolism and gene expression in choline-deficient mice offspring differ with gender, Bioscience, biotechnology, and biochemistry, 85(2), 447-451, 20210120
  11. Rhabdomyolysis After Consumption of Freshwater Fish (Neolissochilus soroides), Wilderness & environmental medicine, 2021
  12. Potential Role of Vitamin B6 in Ameliorating the Severity of COVID-19 and Its Complications, Frontiers in Nutrition, 7, 562051, 20201029
  13. Low-dose ethanol has impacts on plasma levels of metabolites relating to chronic disease risk in samp8 mice, Journal of Nutritional Science and Vitaminology, 2020, 66(6), pp. 553–560(6), 553-560, 20201231
  14. Mungbean seed coat water extract inhibits inflammation in LPSinduced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IjBa/NF-jB, Journal of Food Science and Technology, 57(7), 2659-2668, 202007
  15. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles, AMINO ACIDS, 52(5), 743-753, 20200502
  16. The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment, SCIENTIFIC REPORTS, 9, 20191001
  17. Novel metabolic disturbances in marginal vitamin B-6-deficient rat heart, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 65, 26-34, 201903
  18. Feeding Aspergillus protease preparation combined with adequate protein diet to rats increases levels of cecum gut-protective amino acids, partially linked to Bifidobacterium and Lactobacillus, Bioscience, Biotechnology, and Biochemistry, 83(10), 1901-1911, 20190611
  19. Consumption of Low-Dose of Ethanol Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Rats, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 65(5), 443-450, 2019
  20. High-dose D-glucosamine Consumption Increases Serum and Cecum Levels of Ammonia and Ethanol and Causes Bacterial Overgrowth in Rats, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 25(1), 107-113, 201901
  21. GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 316(2), C162-C174, 201902
  22. Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases, Molecular Nutrition: Vitamins, 283-299, 201901
  23. Beneficial Effects of Dietary Tempeh Prepared with Rhizopus stolonifer on Liver Function in Rats Fed with a High-Fat Diet, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 64(5), 379-383, 2018
  24. Increased intestinal ethanol following consumption of fructooligosaccharides in rats, BIOMEDICAL REPORTS, 9(5), 427-432, 201811
  25. Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(9), 1796-1804, 2017
  26. The effects of tempe fermented with Rhizopus microsporus, Rhizopus oryzae, or Rhizopus stolonifer on the colonic luminal environment in rats, Journal of Functional Foods, 49, 162-167, 201810
  27. Production of Isoflavone Aglycone-enriched Tempeh with Rhizopus stolonifer, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 24(3), 493-499, 201803
  28. Gender Difference and Dietary Supplemental Vitamin B-6: Impact on Colon Luminal Environment, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 64(2), 116-128, 2018
  29. Transgenic mice specifically expressing amphiregulin in white adipose tissue showed less adipose tissue mass, GENES TO CELLS, 23(3), 136-145, 201803
  30. Rice bran wax oleogel: A potential margarine replacement and its digestibility effect in rats fed a high-fat diet, JOURNAL OF FUNCTIONAL FOODS, 39, 250-256, 201712
  31. Consumption of an acid protease derived from Aspergillus oryzae causes bifidogenic effect in rats, NUTRITION RESEARCH, 44, 60-66, 2017
  32. TALEN-mediated targeted editing of the GDE5 gene suppresses fibroblastic cell proliferation, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(11), 2164-2167, 2017
  33. Time-course microarrays reveal early activation of the immune transcriptome in a choline-deficient mouse model of liver injury, LIFE SCIENCES, 184, 103-111, 20170901
  34. Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity, Food Chemistry, 213, 329-335, 20161215
  35. Vasorelaxant effect of 5'-methylthioadenosine obtained from Candida utilis yeast extract through the suppression of intracellular Ca2+ concentration in rat isolated aorta, Journal of Agricultural and Food Chemistry, In Press, 2016
  36. Elution profile of di-peptides on a sulfonated ethylstyrene-divinylbenzene copolymer resin column by high-performance liquid chromatography, Analytical Sciences, 31, 45-50, 20150110
  37. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells, Food Chemistry, 152, 218-224, 2014
  38. ★, Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses, Biochimica et Biophysica Acta- General Subjects, 1840, 3073-3078, 2014

Publications such as books

  1. 2017/11, Science within Food: Up-to-date Advances on Research and Educational Ideas, Vitamin B6: a heart-protective molecule through a novel mechanism of increasing histidine-related compounds, vitamin B6; histidine-related compounds; carnosine; histamine; heart; cardiovascular disease, Formatex Research Center, 2017, November, Scholarly Book, Single work, E, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Norihisa Kato, Noriyuki Yanaka and Hong C. Lai, 978-84-947512-1-9, 299
  2. 2018/01/30, Advances in Industrial Applications of Yeasts, Koji-molds, and Lactic Acid Bacteria, 2018, January, Textbook, J, 加藤範久, 楊 永寿, Kumrungsee T, 978-4-7813-1317-7, 264

Invited Lecture, Oral Presentation, Poster Presentation

  1. Vitamin B6 regulates muscle satellite cell function: A novel possible role of vitamin B6 in muscle regeneration, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Noriyuki Yanaka, Norihisa Kato, Nutrition 2020, 2020/06/04, Without Invitation, English, American Society of Nutrition, Online
  2. 2021 JSBBA Young Scientists Award Lecture: Histidine-containing functional peptides and their applications, Thanutchaporn Kumrungsee, The 59th regular Meeting of the Chugoku-Shikoku Branch of the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), 2021/06/12, With Invitation, English, The Chugoku-Shikoku Branch of the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), Online (Higashihiroshima, Hiroshima)
  3. 2021 JSBBA Young Scientists Award Lecture: Histidine-containing functional peptides and their applications, Thanutchaporn Kumrungsee, Tthe 2021 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2021/03/18, With Invitation, English, The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), Online (Sendai, Miyagi)
  4. A new muscle atrophy model, GDE5 transgenic mice, for searching for food factors preventing sarcopenia, Takumi KOMARU, Kanako SATO, Noriyuki YANAKA, Thanutchaporn KUMRUNGSEE, The 53rd Japan Society of Nutrition and Food Science China-Shikoku Branch Conference (held online), 2020/10/25, Without Invitation, Japanese
  5. Muscle regeneration ability and satellite cell content in a new muscle atrophy model, GDE5 transgenic mice, Takumi KOMARU, Kanako SATO, Noriyuki YANAKA, Thanutchaporn KUMRUNGSEE, The 57th Japan Society for Bioscience and Biotechnology 2020 Chugoku-Shikoku Branch Conference, 2020/09/18, Without Invitation, Japanese
  6. Vitamin B6 deficiency reduces satellite cell number in mouse skeletal muscle fibers, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Norihisa Kato, Noriyuki Yanaka, The 74th Annual Meeting of Japan Society of Nutrition and Food Science, 2020/05/16, Without Invitation, English, Tohoku University, Sendai International Center, Sendai
  7. The potential roles of vitamin B6 in satellite cell functions, Thanutchaporn Kumrungsee, Kai Onishi, Takumi Komaru, Noriyuki Yanaka, The 2020 annual meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry, 2020/03, Without Invitation, Japanese, Kyushu University, Fukuoka
  8. We are in the age when banana, chocolate, and steak may disappear, 1. Thanutchaporn Kumrungsee, INU Student Seminar on Global Citizenship and Peace, 2018/08/10, With Invitation, English, Hiroshima University, Hiroshima University
  9. Vitamin B6 deficiency impairs imidazole homeostasis and energy metabolism in rat heart, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, Norihisa Kato, Nutrition 2018, 2018/06/09, Without Invitation, English, American Society of Nutrition, Boston, MA, USA
  10. Agriculture and Food Innovation: Functional foods as value-added agricultural products for health promotion, Thanutchaporn Kumrungsee, Triple Helix International Seminar: Linking University-Industry-Government, 2018/03/07, With Invitation, English, . University of Guanajuato, Guanajuato, Mexico
  11. Why is vitamin B6 important for your heart and skeletal muscle?, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 2018/03/05, With Invitation, English, Tianjin University of Science and Technology, Tianjin, China, Tianjin University of Science and Technology, Tianjin, China
  12. Vitamin B6: an underestimated compound regulating homeostasis of heart-protective peptides., Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, Norihisa Kato., The First International Conference of “Innovation of Functional Foods in Asia (IFFA), 2018/01/22, Without Invitation, English, Phayao, Thailand
  13. A possible novel mechanism underlying heart-protective effects of vitamin B6, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 46th Annual Meeting of Food and Agriculture Panel United States-Japan Cooperative Program in Natural Resources (UJNR), 2017/11/11, With Invitation, English, Hiroshima, Japan
  14. Decreased levels of putative heart protective metabolites in heart tissues of rats fed a vitamin B6 deficient diet: a metabolomics approach, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Noriyuki Yanaka, and Norihisa Kato, 22nd International Conference of Functional Food Center, 2017/09/22, Without Invitation, English, Boston, MA, USA
  15. Challenging of finding a new type of calmodulin inhibitors, Thanutchaporn Kumrungsee, Noriyuki Yanaka, 22nd International Conference of Functional Food Center, 2017/09/22, Without Invitation, English, Boston, MA, USA
  16. Histidine-related compounds as possible key mediators underlying a heart-protective effect of vitamin B6, Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Norihisa Kato, International Congress on Carnosine and Anserine, 2017/09/12, Without Invitation, English, Louisville, KY, USA
  17. Vitamin B6: A heart protective molecule through a novel mechanism, Thanutchaporn Kumrungsee, 2017 年度(第21回)生物機能研究会, 2017/06/17, With Invitation, English, Hiroshima University, Higashi-shiroshima
  18. フラクトオリゴ糖摂取ラットの大腸内容物、及 び組織のエタノールの増加, Thanutchaporn Kumrungsee、山口 将大 、 Yongshou Yang、加藤 範久, The 71st Annual Meeting of the Japan Society of Nutrition and Food Science, 2017/05/19, Without Invitation, Japanese, The Japan Society of Nutrition and Food Science, Ginowann city, Okinawa
  19. Calmodulin-dependent protein kinase II inhibitory compounds derived from foodstuffs and their possible role in vascular protection, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, BIT 5th Annual World Congress of Food and Nutrition, 2016/11/18, Without Invitation, English, BIT Congress, Kaohsiung, Taiwan
  20. Bioactive compounds in yeast extract and their role in the regulation of blood vessel contraction, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, The Food Factor I Barcelona Conference, 2016/11/02, Without Invitation, English, Formatex Research Center, Barcelona, Spain
  21. Novel active peptides derived from wheat germ hydrolysate as putative nutraceuticals preventing calmodulin-dependent protein kinase II associated diseases, Thanutchaporn Kumrungsee, Toshiro Matsui, Norihisa Kato, 17th International Nutrition & Diagnostics Conference, 2016/10/03, Without Invitation, English, Institute of Nutrition and Diagnostics Pardubice, Prague, Czech Republic
  22. Novel food-derive compounds as potent nutraceuticals for preventing vascular-related diseases, Thanutchaporn KUMRUNGSEE, 2016/07/21, With Invitation, English, Faculty of Agro-Industry, Department of Food Science and Technology, Kasetsart University, Faculty of Agro-Industry, Department of Food Science and Technology, Kasetsart University, Thailand
  23. A novel bioactive compound derived from yeast extract as a potent nutraceutical for preventing vascular-related diseases, Thanutchaporn Kumrungsee, Tomomi Saiki, Masato Omae, Kazuhiro Hamasawa, Toshiro Matsui, Norihisa Kato, 2nd International Conference on Nutraceuticals and Nutrition Supplements, 2016/07/18, Without Invitation, English, Conference Series LLC, Bangkok, Thailand
  24. Food factors for health promotion and disease prevention, Thanutchaporn KUMRUNGSEE, 生物圏科学研究科セミナー, 2016/07/11, With Invitation, English, Graduate School of Biosphere Science, Hiroshima University, Graduate School of Biosphere Science, Hiroshima University

Awards

  1. 2021/03/18, JSBBA Award for Young Scientists, The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA), Histidine-containing functional peptides and their applications

External Funds

Acceptance Results of Competitive Funds

  1. 2021/04/01, 2023/03/31
  2. KAKENHI(Grant-in-Aid for Early-Career Scientists), Elucidation of physiological roles of carnosine in muscle regeneration and its application, 2021/04/01, 2024/03/31
  3. Dietary Aspergillus derived digestive enzymes for increasing GABA and beneficial metabolites, 2021, 2022
  4. 2021 Danone Academic Research Grant, Exploration of potential roles of homocarnosine in brain and its application in pre/probiotic foods, 2021/01/01, 2021/12/31
  5. the 1st Agricultural Chemistry Young Female Researcher Challenge Research Grant, 2021/04/01, 2023/03/31
  6. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2020
  7. Hiroshima University Grant for Female Scholars’ International Collaborative Research , 2018/11/01, 2019/09/30
  8. Grant-in-Aid for International Cooperative Research, Beneficial effects of Mung bean extract, 2018/04/01, 2018/09/30
  9. Collaborative research, Enhancing homocarnosine synthesis in skeletal muscle, 2018/01/01, 2018/12/31

Social Activities

Other Social Contributions

  1. Yumenavi, How to control your appetite? Exploring the relationship between GABA and appetite, Frompage Co.,Ltd, 2021/06, Lecturer, Internet, High school students
  2. HIROSHIMA UNIVERSITY ONLINE OPEN CAMPUS2020, Food factors can help you preserve good health, Hiroshima University, HIROSHIMA UNIVERSITY ONLINE OPEN CAMPUS2020, 2020/08/04, Lecturer, Open college or house, High school students