Tomoyuki Iwata

Last Updated :2025/03/03

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
iwatathiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Philosophy in Dental Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Dental engineering / Regenerative dentistry
  • Medicine,dentistry, and pharmacy;Dentistry;Functional basic dentistry
  • Biology;Biological Science;Molecular biology

Research Keywords

  • mesenchymal stem cell
  • regeneration of periodontal tissue
  • hypoxia
  • micro RNA
  • Periodontal ligament cells
  • Gingival fibroblasts
  • clock genes

Affiliated Academic Societies

  • Japanese Sociaty of Periodontology
  • Japanese Sociaty of Conservative Dentistry
  • Japanese Sociaty of Endodontology
  • The Japanese Society for Bone and Mineral Research
  • Japanese Society for AIDS Research
  • Japanese Society for Infection Prevention and Control
  • Japanese Society for Quality and Safety in Healthcare

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Early Clinical Exposure I
  2. 2024, Undergraduate Education, 3Term, Periodontology I
  3. 2024, Undergraduate Education, 4Term, Periodontology II
  4. 2024, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  5. 2024, Undergraduate Education, 1Term, Basic Practice of Periodontics I
  6. 2024, Undergraduate Education, 2Term, Basic Practice of Periodontics II
  7. 2024, Undergraduate Education, First Semester, Dental Research Practices I
  8. 2024, Undergraduate Education, Second Semester, Dental Research Practices II
  9. 2024, Undergraduate Education, 2Term, Advanced Course in Applied Oral Biology and Medicine
  10. 2024, Undergraduate Education, First Semester, Dental Research Practices III
  11. 2024, Undergraduate Education, Academic Year, Clinical Practice (Periodontics)
  12. 2024, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  13. 2024, Undergraduate Education, Second Semester, Clinical Practice on Oral Health
  14. 2024, Undergraduate Education, Intensive, Clinical practice on oral health
  15. 2024, Undergraduate Education, Intensive, Clinical Practice on Oral Health Management
  16. 2024, Undergraduate Education, 1Term, Quality and Safety Management in Dentistry
  17. 2024, Undergraduate Education, Second Semester, Clinical Practice in Oral Health Engineering
  18. 2024, Undergraduate Education, First Semester, Clinical Practice in Oral Health Engineering
  19. 2024, Undergraduate Education, Second Semester, Clinical Practice in Oral Health Engineering

Research Activities

Academic Papers

  1. Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 58(1), 83-96, 202302
    Link to Paper Search Results by DOI
  2. Clumps of mesenchymal stem cells/extracellular matrix complexes directly reconstruct the functional periodontal tissue in a rat periodontal defect model, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 16(10), 945-955, 202210
    Link to Paper Search Results by DOI
  3. Masticatory dysfunction in patients with diabetic neuropathy: A cross-sectional study, PLOS ONE, 17(6), 2022
    Link to Paper Search Results by DOI
  4. Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-? induces rat calvarial bone regeneration, REGENERATIVE THERAPY, 20, 117-125, 202206
    Link to Paper Search Results by DOI
  5. Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration, JOURNAL OF PERIODONTOLOGY, 93(2), 269-286, 202202
    Link to Paper Search Results by DOI
  6. Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction, JOURNAL OF CLINICAL PERIODONTOLOGY, 38(4), 310-317, 201104
    Link to Paper Search Results by DOI
  7. Characteristics of High-Molecular-Weight Hyaluronic Acid as a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration, TISSUE ENGINEERING PART A, 17(7-8), 955-967, 201104
    Link to Paper Search Results by DOI
  8. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34, 271-277, 20060401
  9. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells, J. Periodontol, 75(9), 1281-1287, 20040401
  10. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation, Biochem. Biophys. Res. Commun., 313(1), 117-124, 20040401
  11. Enhancement of periodontal tissue regeneration by transplantation ofbone marrow mesenchymal stem cells., J. Periodontol, 75(9), 1281-1287, 20040401
  12. Molecular markers distinguish bone marrow mesenchymal stem cell from fibroblasts., Biochem. Biophys. Res. Commun., 332(1), 297-303, 20050401
  13. Regulation of IL-8 by Irsogladine maleate is involved in abolishment of Actinobacillus actinomycetemcomitans-induced reduction of gap-junctional intercellular communication., Cytokine, 34(5-6), 271-277, 20060401
  14. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal Res., 42(3), 283-6, 20070601
  15. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts., J Periodontal. Res., 42(3), 283-286, 20070601
  16. Ceruloplasmin Induces Polymorphonuclear Leukocyte Priming in Localized Aggressive Periodontitis, JOURNAL OF PERIODONTOLOGY, 80(8), 1300-1306, 200908
    Link to Paper Search Results by DOI
  17. Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans, INTERNATIONAL IMMUNOPHARMACOLOGY, 15(2), 340-347, 201302
    Link to Paper Search Results by DOI
  18. The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect, PEPTIDES, 46, 136-142, 201308
    Link to Paper Search Results by DOI
  19. miR-584 Expressed in Human Gingival Epithelial Cells Is Induced by Porphyromonas gingivalis Stimulation and Regulates Interleukin-8 Production via Lactoferrin Receptor, JOURNAL OF PERIODONTOLOGY, 85(6), E198-E204, 201406
    Link to Paper Search Results by DOI
  20. Introduction of a Mixture of beta-Tricalcium Phosphate Into a Complex of Bone Marrow Mesenchymal Stem Cells and Type I Collagen Can Augment the Volume of Alveolar Bone Without Impairing Cementum Regeneration, JOURNAL OF PERIODONTOLOGY, 86(3), 456-464, 201503
    Link to Paper Search Results by DOI
  21. Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration, CYTOTHERAPY, 17(7), 860-873, 201507
    Link to Paper Search Results by DOI
  22. Interleukin-8 induces DNA synthesis, migration and down-regulation of cleaved caspase-3 in cultured human gingival epithelial cells, JOURNAL OF PERIODONTAL RESEARCH, 50(4), 479-485, 201508
    Link to Paper Search Results by DOI
  23. Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration, STEM CELL RESEARCH & THERAPY, 8, 20170426
    Link to Paper Search Results by DOI
  24. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, STEM CELL RESEARCH & THERAPY, 9, 20180321
    Link to Paper Search Results by DOI
  25. The induced RNA-binding protein, HuR, targets 3-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 192(3), 325-336, 201806
    Link to Paper Search Results by DOI
  26. Combined endodontic and periodontal management of a class 3 invasive cervical resorption in a mandibular first molar, CLINICAL CASE REPORTS, 6(10), 2005-2010, 201810
    Link to Paper Search Results by DOI
  27. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, STEM CELL RESEARCH & THERAPY, 9, 20181207
    Link to Paper Search Results by DOI
  28. Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes Generated with Xeno-Free Conditions Facilitate Bone Regeneration via Direct and Indirect Osteogenesis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(16), 20190802
    Link to Paper Search Results by DOI
  29. Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population, CLINICAL ORAL INVESTIGATIONS, 23(11), 4099-4105, 201911
    Link to Paper Search Results by DOI
  30. Periodontal ligament cells regulate osteogenesis via miR-299-5p in mesenchymal stem cells, DIFFERENTIATION, 112, 47-57, 2020
    Link to Paper Search Results by DOI
  31. Optineurin regulates osteoblastogenesis through STAT1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525(4), 889-894, 20200514
    Link to Paper Search Results by DOI
  32. A mandibular second molar with a middle mesial root canal, CLINICAL CASE REPORTS, 8(6), 1015-1020, 202006
    Link to Paper Search Results by DOI
  33. Regulation of osteogenesis via miR-101-3p in mesenchymal stem cells by human gingival fibroblasts, JOURNAL OF BONE AND MINERAL METABOLISM, 38(4), 442-455, 202007
    Link to Paper Search Results by DOI
  34. Oral environment and taste function of Japanese HIV-infected patients treated with antiretroviral therapy, AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 32(7), 829-834, 20200702
    Link to Paper Search Results by DOI
  35. Oral environment and taste function of Japanese HIV-infected patients treated with antiretroviral therapy, Aids Care, 19, 1-6, 2019
  36. Aggressive periodontitis and NOD2 variants, JOURNAL OF HUMAN GENETICS, 65(10), 841-846, 202010
    Link to Paper Search Results by DOI
  37. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530(2), 448-454, 20200917
    Link to Paper Search Results by DOI
  38. Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital, CURRENT HIV RESEARCH, 18(6), 475-479, 2020
    Link to Paper Search Results by DOI
  39. Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells, JOURNAL OF PERIODONTAL RESEARCH, 56(1), 69-82, 202101
    Link to Paper Search Results by DOI
  40. Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages, CELL BIOCHEMISTRY AND BIOPHYSICS, 79(2), 321-336, 202106
    Link to Paper Search Results by DOI
  41. Endodontic Approach and Periodontal Regenerative Therapy for a Mandibular Right Central Incisor Affected by a Perforation and Cemental Tear, INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY, 41(5), E205-E212, 2021
    Link to Paper Search Results by DOI
  42. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification, BIOMEDICINES, 9(10), 202110
    Link to Paper Search Results by DOI

Publications such as books

  1. The Periodontology 4th edition, Risk Factors for Periodontal Disease; 4. Specifics of risk factors, Nagasue Shoten Inc., 2023, 3, Textbook, Joint work, Noriyoshi Mizuno, Kazuhisa Ouhara, Tomoyuki Iwata

Invited Lecture, Oral Presentation, Poster Presentation

  1. Evaluation of oral function and oral environment in hemophilia patients taking anti-HIV drugs, M. Okada, T. Shintani, M. Kawagoe, T. Iwata, N. Yamazaki, T. Fujii, H. Shiba, The 37th Annual Meeting of the Japanese Society for AIDS Reaserch, 2023/12, Without Invitation, Japanese
  2. A cartilaginous construct with bone collar exerts bone-regenerative property via rapid endochondral ossification, Shin Morimoto, Mikihito Kajiya, Susumu Horikoshi, Hiroki Yoshii, Mai Yoshino, Kazuhisa Ouhara, Shinji Matsuda, Tomoyuki Iwata, Shinya Sasaki, Yuta Hamamoto, Misako Tari, Yuri Taniguchi, Tetsuya Yoshimoto, Noriyoshi Mizuno, The 61th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023/10, Without Invitation, Japanese
  3. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Tetsuya Yoshimoto, Shin Morimoto, Tomoyuki Iwata, Noriyoshi Mizuno, The 41st Annual Meeting of the Japanese Society for Bone and Mineral Research, 2022/07, Without Invitation, Japanese
  4. Periodontal treatment (no drug change of calcium blocker) of the elderly periodontitis associated with drug-induced gingival overgrowth and the discovery of early diabetes, Takayoshi Nagahara, Aya Tokumaru, Tomoya Ueda, Shoko Kouno, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 65th Autumn Meeting of the Japanese Society of Periodontology, 2022/09, Without Invitation, Japanese, Sendai
  5. Effect of CD4 count on periodontal therapy in HIV-infected patients, Tomoaki Shintani, Miho Okada, Tomoyuki Iwata, Maiko Kawagoe, Naoya Yamasaki, Nobuko Inoue, Teruhisa Fujii, Hideki Shiba, The 36th Annual Meeting of the Japanese Society for AIDS Reaserch, 2022/11, Without Invitation, Japanese, Hamamatsu
  6. Effect of CD4 count on periodontal therapy in HIV-infected patients, Miho Okada, T. Shintani, T. Iwata, M. Kawagoe, N. Yamasaki, N. Inoue, D. Furutama, K. Takeda, M. Nakaoka, N. Mizuno, T. Fujii, M. Kajiya, H. Shiba, Scientific Meeting of the 61st Hiroshima Prefectural Deantal Association/the 106th Hiroshima University Dental Society, 2022/11, Without Invitation, Japanese, Hiroshima
  7. Comprehensive dental treatment for a patient with cryptogenic arthritis., Takayoshi Nagahara, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 157th Meeting of the Japanese Society of Conservative Dentistry The 24th JSCD/KACD Joint-Scientific Meeting, 2022/11, Without Invitation, Japanese, Okayama
  8. Transplantation of mesenchymal stem cell clumps of MSCs / ECM complexes inducted by combined cartilage /bone differentiation promote bone regeneration through a mode of endochondral ossification., Shin Morimoto, Mikihito Kajiya, Hiroki Yoshii, Mai Yoshino, Tomoyuki Iwata, Noriyoshi Mizuno, The annual meeting of the Japanese Society for Bone and Mineral Research, 2022/07, Without Invitation, Japanese, Gifu
  9. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Shin Morimoto, Hiroki Yoshii, Susumu Horikoshi, Hisakatsu Sone, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, The annual meeting of the Japanese Society of Inflammation and Regeneration, 2022/07, Without Invitation, Japanese, Awaji
  10. A case report of the perodontal regegerative therapy (REGROTH) for vertical bone defect with cemental tear in mandibular right central incisor., Takayoshi Nagahara, Aya Tokumaru, Tomoya Ued,a Shoko Kouno, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 65th spring meeting of theJapanese society of periodontology, 2022/06, Without Invitation, Japanese, Tokyo
  11. Clumps of MSCs/ECM complexes can induce periodontal tissue regeneration via direct differetiation, Hisakatsu Sone, Mikihito Kajiya, Shinya Sasaki, Susumu Horikoshi, Tomoya Ogawa, Hiroki Yoshii, Shin Morimoto, Mai Yoshino, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 65th spring meeting of theJapanese society of periodontology, 2022/06, Without Invitation, Japanese, Tokyo
  12. Cryopreserved clumps of MSCs/ECM complexes treated with INF-r retain immunosuppressive capacity and induce rat calvarial bone regeneration, Tomoya Ogawa,Mikihito Kajiya, Susumu Horikoshi, Hisakatsu Sone, Hiroki Yoshii, Shin Morimoto, Mai Yoshino, Shinya Sasaki, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 60th Meeting of Hiroshima Prefectural Dental Association/The 105th Meeting of Hiroshima University Dental Society, 2021/11, Without Invitation, Japanese, Hiroshima Prefectural Dental Association/Hiroshima University Dental Society, Hiroshima
  13. MicroRNAs induced by humoral factors derived from gingival fibroblasts regulate MSC osteogenesis., Tomoyuki Iwata, Eri Ikeda, Takayoshi Nagahara, Mikihito Kajiya, Kazuhisa Ouhara, Shinya Sasaki, Ryoichi Yagi, Akihiro Konishi, Tsuyoshi Fujita, Noriyoshi Mizuno, The 64th Autumn Meeting of Japanese Society of Periodontology, 2021/10, Without Invitation, Japanese, Japanese Society of Periodontology, Nagoya
  14. Humoral factors secreted from periodontal ligament cells regulates osteogenesis via microRNA in mesenchymal stem cells, Tomoyuki Iwata, Eri Ikeda, Noriyoshi Mizuno, Takayoshi Nagahara, Mikihito Kajiya, Katsuhiro Takeda, Ryoichi Yagi, Akihiro Konishi, Kazuhisa Ouhara, Tsuyoshi Fujita, Hidemi Kurihara, The 63rd Autumn Meeting of the Japanese Society of Periodontology, 2020/07, Without Invitation, Japanese
  15. Correspondence for accident HIV exposure in Hiroshima University Hospital outpatient department, Tomoaki Shintani, Tomoyuki Iwata, Miho Okada, Naoya Yamasaki, Teruhisa Fujii, Hideki Shiba, The33rd annual meeting of the Japanese society for AIDS research, 2019/11, Without Invitation, Japanese
  16. The 3D Culture of Clumps of Mesenchymal Stem Cell/Extracellular Matrix Complexes have effect on the Cell Fate, Nao Komatsu, Mikihito Kajiya, Souta Motoike, Susumu Horikoshi, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 58th Meeting of Hiroshima Prefectural Dental Association/ The 103rd Meeting of Hiroshima University Dental Society, 2019/11, Without Invitation, Japanese
  17. The Elucidation of Developmental Process on Ligature-Induced Experimental Periodontitis in Mice, Tasuku Takemura, Tsuyoshi Fujita, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Tomoyuki Iwata, Misako Tari, Norihito Mizuno, Hidemi Kurihara, International Association for Dental Research, 2019/06, Without Invitation, English
  18. Effect of chondro-inductive Clumps of MSCs/ECM complexes on bone regeneration, Susumu Horikoshi, Mikihito Kajiya, Manabu Takewaki, Nao Komatsu, Souta Motoike, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Tsuyoshi Fujita, Noriyoshi Mizuno, Hidemi Kurihara, The 62th spring meeting of the Japanese society of Periodontology, 2019/05, Without Invitation, Japanese
  19. The Elucidation of Developmental Process on Ligature-Induced Experimental Periodontitis in Mice, Tasuku Takemura , Tsuyoshi Fujita, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Misako Tari, Tomoyuki Iwata, Norihito Mizuno, Hidemi Kurihara, The 62th spring meeting of the Japanese society of Periodontology, 2019/05, Without Invitation, Japanese
  20. Investigation of bone regeneration mechanism induced by clumps of MSCs/ECM complexes., Souta Motoike, Mikihito Kajiya, Nao Komatsu, Susumu Horikoshi, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 62th spring meeting of the Japanese society of Periodontology, 2019/05, Without Invitation, Japanese
  21. Investigation of bone regeneration mechanism induced by clumps of MSCs/ECM complexes., Souta Motoike, Mikihito Kajiya, Nao Komatsu, Susumu Horikoshi, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 18th Congress of the Japanese Society for Regenerative Medicine, 2019/03, Without Invitation, Japanese
  22. Report for the usefulness in Audit System via the Internet of the Hiroshima Safety Dental Service Support Network, Tomoyuki Iwata, Akihiro Sawa, Noriyoshi Mizuno, Miyuki Nakaoka, Yukiko Nagatani, Chika Kozono, Takayoshi Nagahara, Koji Ohta, Tomoaki Shintani, Hideki Shiba, Kazuhiro Tsuga, Hiroyuki Kawaguchi, Hidemi Kurihara, The 34th Annual Meeting of Japanese Society for Infection Prevention and Control, 2019/02, Without Invitation, Japanese
  23. Identification of pathogenic bacteria of apical periodontitis and antimicrobial sensitivity, Hidemi Kurihara, Chika Kozono, Tomoyuki Iwata, Miyuki Nakaoka, Noriyoshi Mizuno, Hideki Shiba, 2019/02, Without Invitation, Japanese
  24. Strategies to improve the hand hygiene compliance in a dental outpatient, Chika Kozono, Yukiko Nagatani, Miyuki Nakaoka, Mikihito Kajiya, Tomoyuki Iwata, Noriyoshi Mizuno, Tomoaki Shinntani, Kouji Oota, Hiroyuki Kawaguchi, Hideki Shiba, Hidemi Kurihara, Kazuhiro Tuga, The 34th Annual Meeting of Japanese Society for Infection Prevention and Control, 2019/02, Without Invitation, Japanese
  25. Investigation for usability of AUDIT System of Hiroshima Safety Dental service Support network to improve the countermeasure against dental safety in the dental clinic, Tomoyuki Iwata, Noriyoshi Mizuno, Miyuki Nakaoka, Hiroyuki Kawaguchi, Kazuhiro Tsuga, Hidemi Kurihara, The 13th Annual Congress of Japanese Society for Quality and Safety in Healthcare, 2018/11, Without Invitation, Japanese, Nagoya
  26. Identification of a causative gene in a family case with aggressive periodontitis by exome sequencing and linkage analysis, Noriyoshi Mizuno, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Katsuhiro Takeda, Tsuyoshi Fujita, Hidemi Kurihara, The 58th General Session of Korean Academy of Periodontology, 2018/10, Without Invitation, English, Seoul, Korea
  27. Investigation of the regulatory mechanism for cell function on mesenchymal stem cells in periodontal regeneration via micro RNA, Tomoyuki Iwata, Takayoshi Nagahara, Noriyoshi Mizuno, Eri Ikeda, Mikihito Kajiya, Ryoichi Yagi, Akihiro Konishi, Masae Kitagawa, Tsuyoshi Fujita, Takashi Takata, Hidemi Kurihara, The 61th Autumn Meeting of the Japanese Society of Periodontology, 2018/10, Without Invitation, Japanese, Osaka
  28. The oral environment and taste function in HIV-positive patients, Shintani T., Yamasaki N., Iwata T., Saitou S., Kitagawa M., Ogawa I., Okada M., Mastui K., Unei H., Fujita K., Hamamoto K., Kinoshita K., Ikeda Y., Fujii T., Kurihara H., Shiba H., The 11th Annual Meeting of Japanese Society for Evidence and the Dental Professional, 2018/08, Without Invitation, Japanese, Tokyo
  29. Surgical endodontic treatment of huge periapical lesion around the maxillary lateral incisor, Nagahara Takayoshi, Yamada Y, Iwata T, Takeda K, Shiba H, The 39th Annual Scientific Meeting of Japan Endodontic Association, 2018/07, Without Invitation, Japanese, Fukuoka
  30. Cryopreserved clumps of mesenchymal stem cell/extracellular matrix complexes retain osteogenic capacity and induce bone regeneration, Souta Motoike, Mikihito Kajiya, Nao Komatsu, Manabu Takewaki, Susumu Horikoshi, Shinji Matsuda, Kazuhisa Ouhara, Tomoyuki Iwata, Katsuhiro Takeda, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara., The 51st meeting of the Hiroshima University Dental Society, 2018/06, Without Invitation, English, Hiroshima
  31. Mechanotransduction in 3D Culture Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Regulates the Cell Fate, Nao Komatsu, Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Susumu Horikoshi, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Tsuyoshi Fujita, Hidemi Kurihara, 7th Hiroshima Conference on Education and Science in Dentistry, 2018/03, Without Invitation, English, Hiroshima
  32. Dental hygienist's activities and the effects in dental clinical support for HIV-infected patients, Okada M, Matsui K,Iwata T, Shintani T, Kinoshita K, Miyahara A, Ikeda Y, Saitou S, Maruyama E, Hamamoto K, Yamasaki N, Fujii T, Shiba H, The 19th Japanese HIV dental medical workshop, 2018/01/07, Without Invitation, Japanese, Tokyo
  33. Dental hygienist's activities and the effects in dental clinical support for HIV-infected patients, Okada M, Matsui K, Iwata T, Sintani T, Kinoshita K, Miyahara A, Ikeda Y, Saitou S, Maruyama E, Hamamoto K, Yamasaki N, Fujii T, Shiba H, The 31th Annual Meeting of the Japanese Society for AIDS Research, 2017/11/25, Without Invitation, Japanese, Japanese Society for AIDS Research, Tokyo
  34. Investigation of the regulatory mechanism for cell function on mesenchymal stem cells in periodontal regeneration by micro RNA, Tomoyuki Iwata, The 36th annual meeting of the japanese society for bone and mineral research, 2017/07/28, Without Invitation, Japanese, japanese society for bone and mineral research, Fukuoka city
  35. The effect of cryopreservation on bone regenerative capacity of Clumps of MSCs/ECM complex, Souta Motoike, Mikihito Kajiya, Kei Takeshita, Manabu Takewaki, Nao Komatsu, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 60th Spring Meeting of The Japanese Society of Periodontology, 2017/05/12, Without Invitation, Japanese, Japanese Society of Periodontology, Fukuoka city
  36. Mechanotransduction in 3D culture clumps of a mesenchymal stem cell/extracellular matrix complex regulates the cell fate, Nao Komatsu, Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Kei Takeshita, Kazuhisa Ouhara, Katsuhiro Takeda, Tomoyuki Iwata, Tsuyoshi Fujita, Hidemi Kurihara, The 60th Spring Meeting of The Japanese Society of Periodontology, 2017/05/12, Without Invitation, Japanese, Japanese Society of Periodontology, Fukuoka city
  37. YAP/TAZ Signaling in 3D Culture Clumps of a MSC/ECM Complex, Nao Komatsu,Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Kei Takeshita, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Tsuyoshi Fujita, Hidemi Kurihara, 95th General Session & Exhibition of the International Association for Dental Research, 2017/03/24, Without Invitation, English, International Association for Dental Research
  38. Investigation of mechanotransduction pathway in the regulation of stem cell fate in 3D culture clumps of an MSCs/ECM complex, Mikihito Kajiya, Nao Komatsu, Souta Motoike, Manabu Takewaki, Kei Takeshita, Kazuhisa Ouhara, Katsuhiro Takeda, Tomoyuki Iwata, Tsuyoshi Fujita, Hidemi Kurihara, The 16th Congress of the Japanese Society for Regenerative Medicine, 2017/03/08, Without Invitation, Japanese, Japanese Society for Regenerative Medicine, Sendai city
  39. The effect of cryopreservation on bone regenerative capacity of Clumps of MSCs/ECM complex, Souta Motoike, Mikihito Kajiya, Kei Takeshita, Manabu Takewaki, Nao Komatsu, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Noriyoshi Mizuno, Tsuyoshi Fujita, Hidemi Kurihara, The 16th Congress of the Japanese Society for Regenerative Medicine, 2017/03/08, Without Invitation, Japanese, Japanese Society for Regenerative Medicine, sendai city
  40. The effect of anti-HIV agents on oral environment and taste function, Shintani T., Yamasaki N., Iwata T., Saito S., Kitagawa M., Ogawa I., Okada M., Mastui K., Hamamoto K., Unei H., Fujita K., Ogawa R., Kinoshita K., Ikeda Y., Fujii T. Shiba H., The 30th Annual meeting of the Japanese Society for AIDS research, 2016/11/25, Without Invitation, Japanese, Kagoshima
  41. Specific gene expression in 3D culture clumps of mesenchymal stem cells/extracellular matrix complex for periodontal regeneration, Nao Komatsu, Mikihito Kajiya, Kei Takeshita, Manabu Takewaki, Souta Motoike, Kazuhisa Ouhara, Katsuhiro Takeda, Tomoyuki Iwata, Tsuyoshi Fujita, Hidemi Kurihara, The 100th Scientific Meeting of Hiroshima Prefecture Dental Association / Hiroshima University Dental Society, 2016/10/30, Without Invitation, Japanese, Hiroshima
  42. Nobel periodontal tissue regeneration therapy using C-MSCs, Manabu Takewaki, Mikihito Kajiya, Kei Takeshita, Nao Komatsu, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Tsuyoshi Fujita, Hidemi Kurihara, The 145th Meeting of the Japanese Society of Conservation Dentistry, 2016/10/28, Without Invitation, Japanese, Matsumoto
  43. The effects of optineurin on osteoblast differentiation, Noriyoshi Mizuno, Shinji Matsuda, Tetsuya Yoshimoto, Tomoyuki Iwata, Mikihito Kajiya, Kazuhisa Ouhara, Katsuhiro Takeda, Tsuyoshi Fujita, Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/08, Without Invitation, Japanese, Niigata
  44. Investigation of regulatory genes for differentiative commitment to periodontal cells on mesenchymal stem cells, Tomoyuki Iwata, Takayoshi Nagahara, Eri Ikeda, Ryoichi Yagi, Yusuke Aida, Akihiro Konishi, Minami Yoshioka, Shu Ishida, Noriyoshi Mizuno, Hideki Shiba, Hidemi Kurihara, The 59th fall meeting of the Japanese society of Periodontology, 2016/10/07, Without Invitation, Japanese, Niigata
  45. A case report of apical hard-tissue deposition by root canal treatment, Takayoshi Nagahara, Katsuhiro Takeda, Tomoyuki Iwata, Hideki Shiba, The 37th Annual Scientific Meeting of JEA, 2016/07/24, Without Invitation, Japanese, Nagoya
  46. Mechanotransduction in 3D culture clumps of a MSC/ECM complex, Nao Komatsu, Mikihito Kajiya, Kei Takeshita, Manabu Takewaki, Souta Motoike, Kazuhisa Ouhara, Katsuhiro Takeda, Tomoyuki Iwata, Tsuyoshi Fujita, Hidemi Kurihara, The 37th Annual Meeting of the Japanese Society of Inflammation and Regeneration, 2016/06/17, Without Invitation, Japanese, Kyoto
  47. The effects of optineurin on periodontal tissue destruction, Shinobu Matsui, Noriyoshi Mizuno, Shinji Matsuda, Manabu Takewaki, Masahiro Yamakawa, Mikihito Kajiya, Kazuhisa Ouhara,Katsuhiro Takeda, Tomoyuki Iwata,Tsuyoshi Fujita,Hidemi Kurihara, The 94th Annual Meeting of the International Association for Dental Research, 2016/06, Without Invitation, English, Seoul, Korea
  48. Investigation of micro RNA for regulation of cell function on mesenchymal stem cells, Tomoyuki Iwata, Takayoshi Nagahara, Eri Kaneda, Minami Yoshioka, Noriyoshi Mizuno, Hideki Shiba, Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/21, Without Invitation, Japanese, Kagoshima
  49. The effect of cryopreservation on bone regenerative capacity of clumps of MSCs/ECM complex, Souta Motoike, Mikihito Kajiya, Kei Takeshita, Manabu Takewaki, Tomoyuki Iwata, Katsuhiro Takeda, Kazuhisa Ouhara, Tsuyoshi Fujita, Hidemi Kurihara, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/21, Without Invitation, Japanese, Kagoshima
  50. Effort by Dental hygienists in dental support for HIV positive patients in Hiroshima University Hospital, Okada M, Matsui K, Iwata T, Nakaoka M, Shiba H, The 59th spring meeting of the Japanese society of Periodontology, 2016/05/21, Without Invitation, Japanese
  51. Effort by Dental hygienists in dental support for HIV positive patients in Hiroshima University Hospital, Okada M, Matsui K, Iwata T, Shintani T, Ogawa Y, Ikeda Y, Kinoshita K, Takada N, Saito S, Yamasaki N, Fujii T, Shiba H, The 29th Annual meeting of the Japanese Society for AIDS research, 2015/12/01, Without Invitation, Japanese, Tokyo
  52. Effect on the expression and activity of histone deacetylase by humoral factors secreted by periodontal cells, Keita Takahashi, Tomoyuki Iwata, Eri Kaneda, Takayoshi Nagahara, Minami Yoshioka, Hidemi Kurihara, The 142nd Meeting of the Japanese Society of Conservative Dentistry, 2015/06/25, Without Invitation, Japanese, Kitakyusyu
  53. To establish anti-inflammatory cytokine producing clumps of MSCs/ECM(C-MSCs)complex ex vivo, Kei Takeshita, Mikihito Kajiya, Manabu Takewaki, Nao Komatsu, Kazuhisa Ouhara, Tomoyuki Iwata, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara, The 88th of Japan Tissue Culture Association, 2015/05/26, Without Invitation, Japanese, Hiroshima
  54. The development of immunomodulatory Clumps of a MSC/ECM complex for novel allograft cell transplantation therapy, Kei Takeshita, Mikihito Kajiya, Manabu Takewaki, Nao Komatsu, Kazuhisa Ouhara, Tomoyuki Iwata, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara, The 58th spring meeting of the Japanese society of Periodontology, 2015/05/15, Without Invitation, Japanese, Chiba
  55. Mechanism analysis of periodontal tissue regeneration by clumps of MSCs/ECM complexes, Hisakatsu Sone, Mikihito Kajiya, Shinya Sasaki, Susumu Horikoshi, Tomoya Ogawa, Hiroki Yoshii, Shin Morimoto, Mai Yoshino, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 60th Meeting of Hiroshima Prefectural Dental Association/The 105th Meeting of Hiroshima University Dental Society, 2021/11, Without Invitation, Japanese, Hiroshima Prefectural Dental Association/Hiroshima University Dental Society, Hiroshima
  56. The inhibitory effect of geniposidic acid in Porphyromonas gingivalis induced halitosis and mouse periodontitis model, Ruoqi Zhai, Kazuhisa Ouhara, Tetsuya Tamura, Yuri Taniguchi, Yuta Hamamoto, Mikihito Kajiya, Shinji Matsuda, Shinya Sasaki, Tomoyuki Iwata, Noriyoshi Mizuno, The 60th Meeting of Hiroshima Prefectural Dental Association/The 105th Meeting of Hiroshima University Dental Society, 2021/11, Without Invitation, Japanese, Hiroshima Prefectural Dental Association/Hiroshima University Dental Society, Hiroshima
  57. YAP/TAZ mechanosignaling regulates cytoprotective factors production in mesenchymal stem cells, Hiroki Yoshii, Mikihito Kajiya, Shin Morimoto, Mai Yoshino, Susumu Horikoshi, Misako Tari, Yuri Taniguchi, Shinya Sasaki, Yuta Hamamoto, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Tetsuya Yoshimoto, Noriyoshi Mizuno, The 61th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023/10, Without Invitation, Japanese
  58. The development of a bone marrow adipose tissue-like in vitro model using clumps of MSCs/ECM complexes., Mai Yoshino, Mikihito Kajiya, Shin Morimoto, Hiroki Yoshii, Tetsuya Yoshimoto, Sususmu Horikoshi, Misako Tari, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Shinya Sasaki, Yuta Hamamoto, Yuri Taniguchi, Noriyoshi Mizuno, The 61th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023/10, Without Invitation, Japanese
  59. Promotion of reosseointegration by brain-derived neurotrophic factor (BDNF) in canine peri-implantitis model, Shoko Kono, Shinya Sasaki, Katsuhiro Takeda, Shinji Matsuda, Tomoyuki Iwata, Kazuhisa Ouhara, Noriyoshi Mizuno, The 61th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023/10, Without Invitation, Japanese
  60. Ligature-induced periodontitis exacerbates non-alcoholic fatty liver irrelevant to gluocse intolerance or obesity, Misako Tari, Mikihito Kajiya, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Shinya Sasaki, Noriyoshi Mizuno, The 61th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023/10, Without Invitation, Japanese
  61. Masticatory dysfunction in patients with diabetic neuropathy, Yuta Hamamoto, Kazuhisa Ouhara, Tsuyoshi Miyagawa, Mikihito Kajiya, Shinji Matsuda, Shinya Sasaki, Tomoyuki Iwata, Noriyoshi Mizuno, The 61th Autumn Annual Meeting of the Japanese Society of Periodontology, 2023/10, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2013, 2014
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  2. KAKENHI, 2012, 2014
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  3. KAKENHI, Identification of responsible gene involved with aggressive periodontitis by homozygosity haplotype analysis, 2011, 2013
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  4. KAKENHI, Detection of disease causing genes of aggressive periodontitis by recessive analysis, 2011, 2012
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  5. KAKENHI, Effect for transcriptional activity by hypoxic condition on periodontal regeneration and inflammation, 2011, 2012
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  6. KAKENHI, The basic study for the progression of the order-made medicine by cytokines for periodontal tissue regeneration, 2009, 2011
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  7. KAKENHI, Investigation of the mechanism of osteogenic induction by clock genes, 2006, 2007
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  8. KAKENHI, 2015, 2017
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  9. KAKENHI, 2015, 2018
  10. KAKENHI, 2015, 2018

Social Activities

History as Peer Reviews of Academic Papers

  1. 2022, Acta Biomaterialia, Others, Reviewer, 2
  2. 2022, Acta Biochimica et Biophysica Sinica, Others, Reviewer, 2
  3. 2022, Tissue and Cell, Others, Reviewer, 1
  4. 2022, Bioengineered, Others, Reviewer, 2
  5. 2022, BMC Oral health, Others, Reviewer, 1
  6. 2022, Cellular and Molecular Life Sciences, Others, Reviewer, 2
  7. 2022, Journal of Function Biomaterials, Others, Reviewer, 1
  8. 2022, GENE journal, Others, Reviewer, 2
  9. 2022, bioengineering, Others, Reviewer, 3
  10. 2022, Oxygen, Others, Reviewer, 1
  11. 2022, Frontiers: cells and development biology, Others, Reviewer, 1
  12. 2022, Biomedicines, Others, Reviewer, 3
  13. 2022, TRASCI, Others, Reviewer, 1
  14. 2023, Acta Biomaterialia, Others, Reviewer, 1
  15. 2023, Journal of Clinical Periodontology, Others, Reviewer, 2
  16. 2023, International Journal of Molecular Sciences, Others, Reviewer, 8
  17. 2023, Cells, Others, Reviewer, 1
  18. 2023, Tissue and Cell, Others, Reviewer, 5
  19. 2023, BMC Oral health, Others, Reviewer, 1
  20. 2023, GENE journal, Others, Reviewer, 2
  21. 2023, Frontiers: cells and development biology, Others, Reviewer, 1
  22. 2023, Biomedicines, Others, Reviewer, 2
  23. 2023, Frontiers in Bioscience-Landmark, Others, Reviewer, 2
  24. 2023, European Journal of Histochemistry, Others, Reviewer, 1
  25. 2023, Journal of Orthopaedic Surgery and Research, Others, Reviewer, 5
  26. 2023, Computational and Structural Biotechnology Journal, Others, Reviewer, 1
  27. 2023, International Journal of Oral Science, Others, Reviewer, 1
  28. 2023, Autoimmunity, Others, Reviewer, 1
  29. 2023, Biology, Others, Reviewer, 2
  30. 2023, Biochemical Genetics, Others, Reviewer, 2
  31. 2023, Biochemical and Biophysical Research Communications, Others, Reviewer, 2
  32. 2023, iScience, Others, Reviewer, 1
  33. 2023, Journal of oral bioscience, Others, Reviewer, 1
  34. 2023, Scientific report, Others, Reviewer, 1
  35. 2023, IJBIOMAC, Others, Reviewer, 1
  36. 2023, heliyon, Others, Reviewer, 2
  37. 2023, Life Sciences, Others, Reviewer, 1
  38. 2023, Cell Biochemistry and Function, Others, Reviewer, 1
  39. 2023, Molecular Basis of Disease, Others, Reviewer, 1
  40. 2023, Current Issues in Molecular Biology, Others, Reviewer, 1