TAKASHI IRIE

Last Updated :2026/05/08

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Associate Professor
E-mail
tiriehiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., Kyoto University
  • Master of Pharmaceutical Science, Kyoto University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • pathogenesis
  • viral replication
  • negative-sense RNA viruses

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Second Semester, Biological Responses
  2. 2026, Undergraduate Education, Intensive, Practice for medical research
  3. 2026, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A

Research Activities

Academic Papers

  1. ★, Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike, CELL, 185(12), 2103-+, 20220609
    Link to Paper Search Results by DOI
  2. ★, Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant, NATURE, 603(7902), 700-+, 20220324
    Link to Paper Search Results by DOI
  3. ★, Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation, NATURE, 602(7896), 300-+, 20220210
    Link to Paper Search Results by DOI
  4. The YLDL sequence within Sendai virus m protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein, JOURNAL OF VIROLOGY, 81(5), 2263-2273, 200703
    Link to Paper Search Results by DOI
  5. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation, NEUROSCIENCE LETTERS, 505(3), 279-281, 20111121
    Link to Paper Search Results by DOI
  6. Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein, JOURNAL OF VIROLOGY, 86(13), 7136-7145, 201207
    Link to Paper Search Results by DOI
  7. Passage of a Sendai Virus Recombinant in Embryonated Chicken Eggs Leads to Markedly Rapid Accumulation of U-to-C Transitions in a Limited Region of the Viral Genome, PLOS ONE, 7(11), 20121121
    Link to Paper Search Results by DOI
  8. Inactivation of Pathogenic Viruses by Plant-Derived Tannins: Strong Effects of Extracts from Persimmon (Diospyros kaki) on a Broad Range of Viruses, PLOS ONE, 8(1), 20130125
    Link to Paper Search Results by DOI
  9. ★, SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion, NATURE, 599(7883), 114-+, 20211104
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. A regulatory mechanism of low expression of mononegavirus L protein by intergenic trinucleotide sequence and its significance., 2021/11/16, Without Invitation, Japanese
  2. A novel anti-apoptotic role of Sendai virus V protein via its interaction with IRF3, 2017/10/25, Without Invitation, English
  3. A regulatory role of intergenic trinucleotides in Sendai viral gene expression, 2017/10/25, Without Invitation, English
  4. Sendai virus V protein plays an antiapoptotic role during infection, The 17th International Congress of Virology, 2017/07, Without Invitation, English, International Union of Microbiological Societies, Singapore
  5. Detailed functional mapping of the paramyxovirus accessory proteins in viral infection, 2018/10/28, Without Invitation, English
  6. Characterization of a Sendai virus isolate producing copyback-type defective viral RNA and its potential as a vaccine adjuvant, The 17th Awaji International Forum in Infection and Immunity, 2018/09, Without Invitation, English
  7. Detailed functional mapping of the paramyxovirus accessory proteins in viral infection, 16th International Conference of Negative Strand Viruses, 2018/06, Without Invitation, English, Verona, Italy
  8. Selective manipulation of multi-functional Sendai virus C protein by single amino acid substitutions, 2016/10, Without Invitation, English
  9. Characterization of the interaction of Sendai virus V protein with multiple host interferon-inducing factors, RIG-I, MDA5 and IRF3, 2015/11, Without Invitation, English
  10. Sendai virus V protein plays an antiapoptotic role during infection, 2015/11, Without Invitation, Japanese
  11. IFN-beta-inducible, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner, The 13th Awaji International Forum in Infection and Immunity in Nara, 2014/09, Without Invitation, Japanese
  12. Paramyxovirus Sendai virus N protein plays a critical role in restricted production of copyback-type defective-interfering genomes to escape from detection by host innate immunity, The 16th International Congress of Virology, 2014/07, Without Invitation, English
  13. Stress granule-like structures are not involved in recognition of Sendai virus infection, The 16th International Congress of Virology, 2014/07, Without Invitation, English
  14. Paramyxovirus Sendai virus N protein plays a critical role on restricted production of copyback-type DI genomes to escape from detection by host innate immunity, The 12th Awaji International Forum in Infection and Immunity, 2013/09, Without Invitation, English
  15. Stress granule-like structures are not involved in recognition of Sendai virus infection, The 12th Awaji International Forum in Infection and Immunity, 2013/09, Without Invitation, English
  16. A novel regulatory mechanism determining the genome polarity in the Mononegavirales, 15th International Conference of Negative Strand Viruses, 2013/06, Without Invitation, English
  17. Different production of a viral RNA species between Sendai virus strains Z and Cantell causes their remarkable difference in interferon inducibility, 15th International Conference of Negative Strand Viruses, 2013/06, Without Invitation, English
  18. A novel regulatory mechanism for polarity of mononegavirus RNA synthesis, The 11th Awaji International Forum in Infection and Immunity, 2012/09, Without Invitation, English
  19. The accessory C protein of Sendai virus is involved in folding of the N protein, The 11th Awaji International Forum in Infection and Immunity, 2012/09, Without Invitation, Japanese
  20. Sendai virus C protein regulates genomic and antigenomic RNA synthesis during the course of infection, The 15th International Congress of Virology, 2011/10, Without Invitation, English
  21. The accessory C protein of Sendai virus is involved in folding of the N protein, The 15th International Congress of Virology, 2011/10, Without Invitation, English
  22. Characterization of a Sendai virus isolate producing copyback-type defective viral RNA and its potential as an effective vaccine adjuvant, Takashi Irie, Asuka Yoshida, Kouji Sakai, Ryoko Kawabata, Takemasa Sakaguchi, Influenza and Other Infections Symposium, 2019/02/19, Without Invitation, English

Social Activities

Organizing Academic Conferences, etc.

  1. 2018/04

History as Peer Reviews of Academic Papers

  1. 2018, Frontiers in Microbiology, Editor, 7
  2. 2018, Journal of Virualized Experiments, Editor, 1