TAKASHI IRIE

Last Updated :2024/02/01

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Associate Professor
E-mail
tiriehiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Ph.D., Kyoto University
  • Master of Pharmaceutical Science, Kyoto University

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Virology

Research Keywords

  • pathogenesis
  • viral replication
  • negative-sense RNA viruses

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, Year, Biological Responses
  2. 2023, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  3. 2023, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  4. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Virology
  5. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Virology
  6. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Virology
  7. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Virology

Research Activities

Academic Papers

  1. ★, Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike, CELL, 185(12), 2103-+, 20220609
  2. ★, Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant, NATURE, 603(7902), 700-+, 20220324
  3. ★, Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation, NATURE, 602(7896), 300-+, 20220210
  4. The YLDL sequence within Sendai virus m protein is critical for budding of virus-like particles and interacts with Alix/AIP1 independently of C protein, JOURNAL OF VIROLOGY, 81(5), 2263-2273, 200703
  5. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation, NEUROSCIENCE LETTERS, 505(3), 279-281, 20111121
  6. Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein, JOURNAL OF VIROLOGY, 86(13), 7136-7145, 201207
  7. Passage of a Sendai Virus Recombinant in Embryonated Chicken Eggs Leads to Markedly Rapid Accumulation of U-to-C Transitions in a Limited Region of the Viral Genome, PLOS ONE, 7(11), 20121121
  8. Inactivation of Pathogenic Viruses by Plant-Derived Tannins: Strong Effects of Extracts from Persimmon (Diospyros kaki) on a Broad Range of Viruses, PLOS ONE, 8(1), 20130125
  9. ★, SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion, NATURE, 599(7883), 114-+, 20211104

Invited Lecture, Oral Presentation, Poster Presentation

  1. A regulatory mechanism of low expression of mononegavirus L protein by intergenic trinucleotide sequence and its significance., 2021/11/16, Without Invitation, Japanese
  2. A novel anti-apoptotic role of Sendai virus V protein via its interaction with IRF3, 2017/10/25, Without Invitation, English
  3. A regulatory role of intergenic trinucleotides in Sendai viral gene expression, 2017/10/25, Without Invitation, English
  4. Sendai virus V protein plays an antiapoptotic role during infection, The 17th International Congress of Virology, 2017/07, Without Invitation, English, International Union of Microbiological Societies, Singapore
  5. Detailed functional mapping of the paramyxovirus accessory proteins in viral infection, 2018/10/28, Without Invitation, English
  6. Characterization of a Sendai virus isolate producing copyback-type defective viral RNA and its potential as a vaccine adjuvant, The 17th Awaji International Forum in Infection and Immunity, 2018/09, Without Invitation, English
  7. Detailed functional mapping of the paramyxovirus accessory proteins in viral infection, 16th International Conference of Negative Strand Viruses, 2018/06, Without Invitation, English, Verona, Italy
  8. Selective manipulation of multi-functional Sendai virus C protein by single amino acid substitutions, 2016/10, Without Invitation, English
  9. Characterization of the interaction of Sendai virus V protein with multiple host interferon-inducing factors, RIG-I, MDA5 and IRF3, 2015/11, Without Invitation, English
  10. Sendai virus V protein plays an antiapoptotic role during infection, 2015/11, Without Invitation, Japanese
  11. IFN-beta-inducible, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner, The 13th Awaji International Forum in Infection and Immunity in Nara, 2014/09, Without Invitation, Japanese
  12. Paramyxovirus Sendai virus N protein plays a critical role in restricted production of copyback-type defective-interfering genomes to escape from detection by host innate immunity, The 16th International Congress of Virology, 2014/07, Without Invitation, English
  13. Stress granule-like structures are not involved in recognition of Sendai virus infection, The 16th International Congress of Virology, 2014/07, Without Invitation, English
  14. Paramyxovirus Sendai virus N protein plays a critical role on restricted production of copyback-type DI genomes to escape from detection by host innate immunity, The 12th Awaji International Forum in Infection and Immunity, 2013/09, Without Invitation, English
  15. Stress granule-like structures are not involved in recognition of Sendai virus infection, The 12th Awaji International Forum in Infection and Immunity, 2013/09, Without Invitation, English
  16. A novel regulatory mechanism determining the genome polarity in the Mononegavirales, 15th International Conference of Negative Strand Viruses, 2013/06, Without Invitation, English
  17. Different production of a viral RNA species between Sendai virus strains Z and Cantell causes their remarkable difference in interferon inducibility, 15th International Conference of Negative Strand Viruses, 2013/06, Without Invitation, English
  18. A novel regulatory mechanism for polarity of mononegavirus RNA synthesis, The 11th Awaji International Forum in Infection and Immunity, 2012/09, Without Invitation, English
  19. The accessory C protein of Sendai virus is involved in folding of the N protein, The 11th Awaji International Forum in Infection and Immunity, 2012/09, Without Invitation, Japanese
  20. Sendai virus C protein regulates genomic and antigenomic RNA synthesis during the course of infection, The 15th International Congress of Virology, 2011/10, Without Invitation, English
  21. The accessory C protein of Sendai virus is involved in folding of the N protein, The 15th International Congress of Virology, 2011/10, Without Invitation, English
  22. Characterization of a Sendai virus isolate producing copyback-type defective viral RNA and its potential as an effective vaccine adjuvant, Takashi Irie, Asuka Yoshida, Kouji Sakai, Ryoko Kawabata, Takemasa Sakaguchi, Influenza and Other Infections Symposium, 2019/02/19, Without Invitation, English

Social Activities

Organizing Academic Conferences, etc.

  1. 2018/04

History as Peer Reviews of Academic Papers

  1. 2018, Frontiers in Microbiology, Editor, 7
  2. 2018, Journal of Virualized Experiments, Editor, 1