TAKAHIRO NII

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
Web Site
https://nrid.nii.ac.jp/ja/nrid/1000090804873/
https://researchmap.jp/tanii4147
https://www.anat.hiroshima-u.ac.jp/
E-mail
taniihiroshima-u.ac.jp
Other Contact Details
1-4-4, Kagamiyama, Higashi-Hiroshima, Japan
TEL : (+81)82-424-4147 FAX : (+81)82-424-7958
Self-introduction
I work on the research about enhancement of mucosal barrier function and improvement of egg production for health and secure poultry production of chickens. In particular, I focus on the intestinal environment and the network between intestine and surrounding organs such as liver, brain and reproductive organs.

Basic Information

Major Professional Backgrounds

  • 2017/04/01, 2019/03/31, Hiroshima University, Academy of Agricultural Science Unit, Graduate School of Biosphere Science, Assistant Professor
  • 2015/04/01, 2017/03/15, Nippon-ham Foods Ltd., R&D Center, Researcher
  • 2013/04/01, 2015/03/31, Hiroshima University, Gradate School of Biosphere Science, Research Fellow of the Japan Society for the Promotion of Science (DC2)

Educational Backgrounds

  • Hiroshima University, Graduate School of Biosphere Science, Department of Bioresource Science, Ph.D. Agriculture, 2012/04/01, 2015/03/23
  • Hiroshima University, Graduate School of Biosphere Science, Department of Bioresource Science, M.Sc. Agriculture, 2010/04/01, 2012/03/23
  • Nippon Veterinary and Life Science University, Faculty of Applied Life Science, B.Sc. Agriculture, 2006/04/01, 2010/03/11

Academic Degrees

  • Hiroshima University
  • Hiroshima University

Research Fields

  • Agricultural sciences;Animal life science;Animal production science

Research Keywords

  • Avian
  • mucosal immunity
  • digestive tract
  • cellular immunity
  • reproductive organ
  • egg laying function
  • probiotics

Affiliated Academic Societies

  • Japan Poultry Science Association
  • Japanese Society of Animal Science
  • Kansai Animal Science Society
  • Poultry Science Association (USA)

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, 1Term, Environmental Sciences for Bioproduction
  2. 2025, Undergraduate Education, Intensive, Laboratory Work in General Biology II
  3. 2025, Undergraduate Education, 3Term, Research Front of Bioresource Science
  4. 2025, Undergraduate Education, 3Term, Animal Functional Anatomy
  5. 2025, Undergraduate Education, 1Term, Animal Physiology and Production
  6. 2025, Undergraduate Education, Intensive, Laboratory and Field Works in Animal Production I
  7. 2025, Undergraduate Education, Second Semester, Graduation Thesis I
  8. 2025, Undergraduate Education, First Semester, Graduation Thesis II
  9. 2025, Undergraduate Education, Second Semester, Graduation Thesis III
  10. 2025, Undergraduate Education, Intensive, Life, food and agricultural education through experimental studies of dairy farming
  11. 2025, Undergraduate Education, Intensive, (AIMS) Introduction Physiology of Domestic Animals
  12. 2025, Undergraduate Education, Intensive, Introductory Physiology of Domestic Animals
  13. 2025, Graduate Education (Master's Program) , 1Term, Exercises in Bioresource Science A
  14. 2025, Graduate Education (Master's Program) , 2Term, Exercises in Bioresource Science A
  15. 2025, Graduate Education (Master's Program) , 3Term, Exercises in Bioresource ScienceB
  16. 2025, Graduate Education (Master's Program) , 4Term, Exercises in Bioresource ScienceB
  17. 2025, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Bioresource Science
  18. 2025, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Bioresource Science
  19. 2025, Graduate Education (Master's Program) , 2Term, Animal Production Science I
  20. 2025, Graduate Education (Master's Program) , 4Term, Animal Production Science II
  21. 2025, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences

Research Activities

Academic Papers

  1. ★, Effects of oligosaccharides on performance, intestinal morphology, microbiota and immune reactions in laying hens challenged with dextran sodium sulfate., Poultry Science, 2024
  2. Aging-associated increased nitric oxide production is a potential cause of inferior eggshell quality produced by aged laying hens., Theriogenology, 205, 63-72, 2023
  3. ★, Intravaginal injection of Lactobacillus johnsonii may modulates oviductal microbiota and mucosal barrier function of laying hens, Poultry Science, 102, 102699, 2023
  4. Effects of Newcastle disease and infectious bronchitis vaccine and yeast products feeding on the innate immune system in the proventriculus and ileum of broiler chicks., Journal of Poultry Science, 60, 20230105
  5. ★, Relationship between mucosal barrier function of the oviduct and intestine and egg productive system of laying hens., The Journal of Poultry Science, 2022
  6. ★, Lactobacillus reuteri Enhances the Mucosal Barrier Function against Heat-killed Salmonella Typhimurium in the Intestine of Broiler Chicks, JOURNAL OF POULTRY SCIENCE, 57(2), 148-159, 202004
    Link to Paper Search Results by DOI
  7. ★, Intestinal inflammation induced by dextran sodium sulphate causes liver inflammation and lipid metabolism disfunction in laying hens, POULTRY SCIENCE, 99(3), 1663-1677, 202003
    Link to Paper Search Results by DOI
  8. ★, Effects of Oral Administration of Lactobacillus reuteri on Mucosal Barrier Function in the Digestive Tract of Broiler Chicks, JOURNAL OF POULTRY SCIENCE, 57(1), 67-76, 202001
    Link to Paper Search Results by DOI
  9. ★, Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and the subsequent recruitment of immunocompetent cells in the oviduct of laying and molting hens., Poultry Science, 90(2), 2332-2341, 2011
  10. ★, Effects of interleukin-1 beta and -6 on the expression of ion transporters for mineralization of eggshell in cultured uterine mucosal tissue of hen, The Journal of Poultry Science, 2018
  11. ★, The effect of estrogen on the early cytotoxic response to IB virus infection in hen oviduct, Veterinary Immunology and Immuno pathology, 164(42737), 56-66, 2015
  12. ★, Effects of avian infectious bronchitis virus antigen on eggshell formation and immunoreaction in hen oviduct, Theriogenology, 81(8), 1129-1138, 2014
  13. ★, Effects of repeated lipopolysaccharide stimulation on the development of antigen-presenting cells and T cells pool in hen vagina, Journal of Poultry Science, 50(1), 83-89, 2013
  14. ★, Slight Disruption in Intestinal Environment by Dextran Sodium Sulfate Reduces Egg Yolk Size Through Disfunction of Ovarian Follicle Growth., Frontiers in Physiology, 2021
  15. Modulation of the innate immune system by lipopolysaccharide in the proventriculus of chicks inoculated with or without Newcastle disease and infectious bronchitis vaccine., Poultry Science, 2022
  16. Local Heat Treatment of Goat Udders Influences Innate Immune Functions in Mammary Glands, JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 26(4), 387-397, 202112
    Link to Paper Search Results by DOI
  17. Investigation of the binding of goat cathelicidin-7 to lipopolysaccharide and leucocidal suppression of pro-inflammatory cytokines, SMALL RUMINANT RESEARCH, 168, 101-106, 201811
    Link to Paper Search Results by DOI
  18. Expression of pro- and anti-inflammatory cytokines and chemokines during the ovulatory cycle and effects of aging on their expression in the uterine mucosa of laying hens, CYTOKINE, 111, 303-308, 201811
    Link to Paper Search Results by DOI
  19. Changes in the expression of avian β-defensin (AvBDs) and proinflammatory cytokines and localization of AvBD2 in the intestine of broiler embryos and chicks during their growth., Journal of Poultry Science, 2018
  20. Effects of avian infectious bronchitis Newcastle disease and Mareks disease vaccinations on the expression of Toll like receptors and avian beta-defensins in the kidneys of broiler chicks., Poultry Science, 2020
  21. Seasonal variations in the concentration of antimicrobial components in milk of dairy cows., Animal Science Journal, 91(1), e13427, 2020
  22. Effect of antibiotic treatment on microbial composition and expression of antimicrobial peptides and cytokines in the chick cecum, POULTRY SCIENCE, 99(7), 3385-3392, 202007
    Link to Paper Search Results by DOI
  23. Effect of oral administration of colostrum whey to peripartum goat on antimicrobial peptides in postpartum milk., Animal Science Journal, 91(1), e13365, 2020
  24. Effects of probiotics Lactobacillus reuteri and Clostridium butyricum on the expression of toll-like receptors, pro- and anti-inflammatory cytokines, and antimicrobial peptides in broiler chick intestine., Journal of Poultry Science, 2020
  25. Effects of Toll-like Receptor Ligands on the Expression of Proinflammatory Cytokines and Avian beta-defensins in Cultured Chick Intestine, JOURNAL OF POULTRY SCIENCE, 57(3), 210-222, 202007
    Link to Paper Search Results by DOI
  26. Effects of intrauterine infusion of bacterial lipopolysaccharides on the mammary gland inflammatory response in goats, VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 219, 202001
    Link to Paper Search Results by DOI
  27. Effects of the routine multiple vaccinations on the expression of innate immune molecules and induction of histone modification in ovarian cells of layer chicks, POULTRY SCIENCE, 98(10), 5127-5136, 201910
    Link to Paper Search Results by DOI
  28. Effects of Salmonella enteritidis Vaccination on the Expression of Innate Immune Molecules and Histone Modifications in the Follicular Theca of Laying Hens, JOURNAL OF POULTRY SCIENCE, 56(4), 298-307, 201910
    Link to Paper Search Results by DOI
  29. Age-related modulation of the isthmic and uterine mucosal innate immune defense system in laying hens, POULTRY SCIENCE, 98(7), 3022-3028, 201907
    Link to Paper Search Results by DOI
  30. Short communication: Production of antimicrobial peptide S100A8 in the goat mammary gland and effect of intramammary infusion of lipopolysaccharide on S100A8 concentration in milk, JOURNAL OF DAIRY SCIENCE, 102(5), 4674-4681, 201905
    Link to Paper Search Results by DOI
  31. Effects of TLR ligands on the expression of cytokines and possible role of NFκB in its process in the theca of chicken follicles., Journal of Poultry Science, 2018
  32. Innate antiviral immune response against infectious bronchitis virus and involvement of prostaglandin E2 in the uterine mucosa of laying hens, THERIOGENOLOGY, 110, 122-129, 20180401
    Link to Paper Search Results by DOI
  33. Changes in plasma concentrations of S100A7 and S100A8 in dairy cows during pregnancy., Reproduction in Domestic Animals, 1-3, 2018
  34. Modulatory roles of proinflammatory cytokines on the expression of cathelicidins in the lower regions of the oviduct of laying hens, Cytokine, 99, 66-72, 2017
  35. Innate immune functions in hen reproductive organs, Avian Biology Research, 7(1), 39-47, 2014
  36. Expression of Toll-like receptors and effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokine in the testis and epididymis of roosters., Poultry Science, 91(8), 1997-2003, 2012
  37. Effects of oral administration of colostrum whey in peripartum goat on antimicrobial peptides in postpartum milk, ANIMAL SCIENCE JOURNAL, 91(1), 2020
    Link to Paper Search Results by DOI
  38. Effects of avian infectious bronchitis with Newcastle disease and Marek's disease vaccinations on the expression of toll-like receptors and avian beta-defensins in the kidneys of broiler chicks, POULTRY SCIENCE, 99(12), 7092-7100, 202012
    Link to Paper Search Results by DOI
  39. Translocation of intrauterine-infused bacterial lipopolysaccharides to the mammary gland in dexamethasone-treated goats., Reproduction in Domestic Animals, 55, 1688-1697, 2020
  40. Effect of temporary cessation of milking on the innate immune components in goat milk., Journal of Dairy Science, 104(9), 10374-10381, 2021

Invited Lecture, Oral Presentation, Poster Presentation

  1. Effect Of Lactoferrin on Biofilm Formation of Bovine Mastitis-causing Staphylococcus Species., Kumala Seraphina, Takahiro Nii, Naoki Suzuki, Naoki Isobe., 2024/09/10, Without Invitation, English
  2. Oral administration of probiotics to laying hens enhances the barrier function of the oviduct mucosa., Shinkoda T, Suzuki N, Isobe N, Yoshimura Y, Nii T, 10th Internatinal seminorof tropical Animal Production (ISTAP), 2023/11/08, Without Invitation, English, Jpgjalarta, Indonesia
  3. Effect of feeding gluco-oligosaccharides on egg-laying function and intestin and liver damage in laying hens under disruption of intestinal environment., Aika Koyanagi, Naoki Suzuki, Naoki Isobe, Yukinori Yoshimura, Takehiko Hayakawa, Tomoo Wada, Takahiro Nii, Japan Poultry Science Association, 2023 Fall Meeting, 2023/09/21, Without Invitation, Japanese
  4. Changes in the expression of taste receptors in the esophagus and crop during growth of chicks, Yayako Oishi, Yoshimitsu Ouchi, Naoki Suzuki, Naoki Isobe, Fuminori Kawabata, Takashi Bungo, Takahiro Nii, Japan Poultry Science Association, 2023 Fall Meeting, 2023/09/21, Without Invitation, Japanese
  5. New Potential Uses of Probiotics in laying Hens., Takahiro Nii, International Symposium on the UN's Sustainable Development Goals, 2023/09/14, With Invitation, English
  6. Effects of intra-vaginal administration of lactic acid bacteria on the oviductal mucosal barrier function of the laying hens., Shinkoda T, Isobe N, Yoshimura Y, Nii T, The 9th International Seminar on Tropical Animal Production, 2021/09/21, Without Invitation, English, Indonesia
  7. Effects of Partially Hydrolyzed Guar Gum Feeding on Intestinal Environment of Laying Hens., Takahiro Nii, Naoki Isobe, Yukinori Yoshimura, The 9th International Seminar on Tropical Animal Production (ISTAP), 2021/09/21, Without Invitation, English
  8. Effects of the Probiotics on the Mucosal Barrier Function of the Gastrointestinal Tract of Broiler Chicks., Nii T, Isobe N, Yoshimura Y, 11th Asia Pacific Poultry Conference, 2018/03/25, Without Invitation, English, A Royal Meridien Hotel, Bangkok, Thailand

Awards

  1. 2023/11/09, Best oral presenter at the 10th International Seminar on Tropical Animal Production (ISTAPX), Dean Faculty of Animal Science Universitas Gadjah Mada, Oral administration of probiotics to laying hens enhances the barrier function of the oviduct mucosa.
  2. 2023/09/19, The 2023 Award for Excellence in Reviewing for Animal Science Journal in 2022, Animal Science Journal
  3. 2021/03/27, Young Scientist Prize by the Japan Poultry Science Association, Japan Poultry Science Association, Studies on the relationship between mucosal immune function of the intestine and oviduct and egg production in laying hens
  4. 2015, THE 2015 AWARDS OF THE DIMITRIS N. CHORAFAS FOUNDATION, DIMITRIS N. CHORAFAS FOUNDATION
  5. 2014, Excellent Student Scholarship in Hiroshima University (2014), Hiroshima University
  6. 2014, Presentation Award of Kansai Animal Science Society, Kansai Animal Science Society
  7. 2013, Excellent Student Scholarship in Hiroshima University (2013), Hiroshima University
  8. 2013, Presentation Award of Japan Poultry Science Association, Japan Poultry Science Association
  9. 2011, Excellent Student Scholarship in Hiroshima University (2011), Hiroshima university
  10. 2010, Incentive Award for Young Investigators of the Annual Meeting of Japanese Avian Endocrinology Society, Japanese Avian Endocrinology Society
  11. 2019/09/24, Best oral presenter, Dean of Faculty of Animal Science, Universitas Gadjah Mada, Chairman of Organizing Committee, Effect of low milking frequency on the concentration of antimicrobial peptides in goat milk

External Funds

Acceptance Results of Competitive Funds

  1. Grant-in-Aid for Scientific Research(B), 2021/04/01, 2025/03/31
  2. Grant-in-Aid for Scientific Research (C), 2021/04/01, 2024/03/31
  3. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2021/04/01, 2024/03/31
  4. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2020
  5. KAKENHI(Grant-in-Aid for Research Activity Start-up), 2017, 2018
  6. JSPS Research Fellowship for Young Scientists DC2, 2013/04/01, 2015/03/31

Social Activities

History as Committee Members

  1. Councilor, 2024/04, Japan Poultry Science Association
  2. Reviewer Board, 2020/05, Biology ? Open Access Journal
  3. Editorial Board, 2020/04, Japan Poultry Science Association