Fumihiro Morishita

Last Updated :2024/04/03

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor

Basic Information

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Natural Science, Japan, 1985/04, 1988/07
  • Hiroshima University, Faculty of Science, Japan, 1979/04, 1983/03

Academic Degrees

  • Doctor of Science, Hiroshima University
  • Master of Science, Hiroshima University

Research Fields

  • Biology;Basic biology;Animal physiology / Animal behavior

Research Keywords

  • post-translational modification
  • Immunohistochemistry|in situ hybridization
  • signal transduction|D-amino acid
  • molecular biology|neuropeptides
  • RT-PCR|antagonist
  • bioactive peptides|neuropeptide
  • Physiological function|peptide
  • peptide synthesis|D-amino acid
  • structure|gene expression
  • hormone

Educational Activity

Course in Charge

  1. 2024, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  2. 2024, Undergraduate Education, 1Term, Seminar on Biological Science
  3. 2024, Undergraduate Education, 2Term, Basic Biological Science B
  4. 2024, Undergraduate Education, 4Term, Animal Physiology A
  5. 2024, Undergraduate Education, 2Term, Animal Physiology B
  6. 2024, Undergraduate Education, Second Semester, Seminar for Molecular Physiology
  7. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology II
  8. 2024, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  9. 2024, Undergraduate Education, 3Term, Laboratory Work in Biology A
  10. 2024, Graduate Education (Master's Program) , 1Term, Seminar for Advanced Research in Basic Biology A
  11. 2024, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology B
  12. 2024, Graduate Education (Master's Program) , 1Term, Seminar for Advanced Research in Basic Biology C
  13. 2024, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology D
  14. 2024, Graduate Education (Doctoral Program) , 2Term, Seminar for Advanced Research in Basic Biology E
  15. 2024, Graduate Education (Doctoral Program) , 3Term, Seminar for Advanced Research in Basic Biology F

Research Activities

Academic Papers

  1. Long-term Xenopus laevis tadpole -heart-organ-culture: Physiological changes in cholinergic and adrenergic sensitivities of tadpole heart with thyroxine-treatment, Current Research in Physiology, 6, 100100, 20230607
  2. Concomitant downregulation of neuropeptide genes in a marine snail with consecutive sexual maturation after a nuclear disaster in Japan, FRONTIERS IN ENDOCRINOLOGY, 14, 20230310
  3. Subtypes of beta adrenergic receptors mediating pigment dispersion in chromatophores of the medaka, Oryzias latipes, Comp. Biochem. Physiol., 81C(2), 279-285, 1985
  4. Responses of the melanophores of the medaka, Oryzias latipes, to adrenergic drugs - Evidence for involvement of alpha 2 adrenergic receptors mediating melanin aggregation, Comp. Biochem. Physiol., 88C(1), 69-74, 1987
  5. Subtype of alpha adrenoceptors mediating leucosome aggregation in medaka leucophores, J. Sci. Hiroshima Univ., 33(Ser. B, Division 1), 99-112, 1989
  6. Coexistence of beta 1- and beta 2-adrenoceptors in the melanophore of the goby Tridentiger obscurus, Pigment Cell Res., 3(4), 192-199, 1990
  7. Alpha-2 adrenoceptor mediates pigment aggregation within melanophores fo the goby, Tridentiger obscurus., J. Sci. Hiroshima Univ., 34, 29-39, 1990
  8. The background adaptation of the flatfish, Paralichithys olivaceus., Physiol. Behavior, 50, 185-188, 1991
  9. Measurement of background-visual field in flatfishes by CRT display method., Marine Behavior Physiol., 19, 285-290, 1992
  10. Two S-Iamide poptides, AKSGFVRIamide and VSSFVRIamide, isolated from an annelide, Perinereis vancaurica., Biol. Bulletin, 184, 216-222, 1993
  11. Possible involvement of pertussis toxin-sensitive GTP-biniding protein in the alpha2-adrenoceptor-mediated melanosome-aggregation reoponse of goldfish melanophores, J. Exp. Zool., 266, 173-180, 1993
  12. Inhibition of adenylate cyclase activity in the goldfish melanophores is mediated by a2-adrenoceptors and a pertussis toxin-sensitive GTP-binding protein., J. Comp. Physiol. , 163B, 533-540, 1993
  13. A myomodulin-CARP-related peptide isolated from a polychaete annelid, Perinereis vancaurica, Zool. Sci., 11(1), 33-38, 1994
  14. Effects of myomodulin-CARP-family peptides and analogues on the anterior byssus retractor muscle of Mytilus edulis, Peptide Chem., 1994, 289-292, 1995
  15. Bioactive peptides of annelids are closely related to those of molluscs, Acta Biol. Hungarica, 46(2-4), 453-456, 1995
  16. The effects of activators of G-proteins, mastoparan and compound 48/80, on the G-protein/adenylate cyclase in cultured melanophores of the black-moor goldfish, Carassius auratus, J.Comp. Physiol., B166, 467-472, 1996
  17. Subtype of b-adrenoceotprs in the melanophore of Oryzias latipes, Bull. Fac. Life Environ. Sci. Shimane Univ. , 1, 5-7, 1996
  18. A Novel D-Amino-acid-containing Peptide Isolated from Aplysia Heart, Biochem. Biophys. Res. Commun., 240(2), 354-358, 1997
  19. Characterization of binding of the annelidan myoactive peptides, GGNG peptides, to tissues of the earthworm, Eisenia foetida, J. Exp. Zool., 279, 562-570, 1997
  20. Immunochemical demonstration of Eisenia tetradecapeptide, a bioactive peptide isolated from the gut of the earthworm Eisenia foetida, in tissues of the earthworm, Cell Tissue Res., 288, 567-573, 1997
  21. Immunohistochemical localization of annetocin, an earthworm oxytocin-related peptide, and identification and ultrastructural characteristics of the annetocin-secretory cells in the oligochaete earthworm Eisenia foetida, Zool. Sci., 15, 381-388, 1998
  22. Release of proteins and polysaccharides from the albumen gland of the freshwater snail Helisoma duryi: Effect of cAMP and brain extracts, J. Comp. Physiol. , 182, 817-825, 1998
  23. Phylogenetic aspects of structure and action of neuropeptides, Proc. 7th Alahori Conference, 7, 103-108, 1998
  24. The Aplysia Mytilus inhibitory peptide-related peptides: Identification, cloning, processing, distribution, and action, J. Neurosci., 19(21), 9618-9634, 1999
  25. b-adrenergic receptor subtypes in melanophores of the marine gobies Tridentiger trigonocephalus and Chasmichthys gulosus, Pigment Cell Res, 12, 206-217, 1999
  26. Physiological effect and immunohistochemical distribution of a novel D-amino-acid containing cardioactive peptide isolated from of Aplysia heart, Peptide Sci., 1998, 165-168, 1999
  27. Localization of leech excitatory peptide, a member of the GGNG peptides, in the central nervous system of a leech (Whitmania pigra) by immunohistochemistry and in situ hybridization, Cell Tissue Res., 297, 155-162, 1999
  28. Immunohistochemical localization of C-RFamide, FMRF-related peptide, in the brain of the goldfish, Carassius auratus, Zool. Sci., 17, 1067-1074, 2000
  29. Comparative aspects of invertebrate neuropeptides, Acta Biol. Hungarica, 51, 111-132, 2000
  30. Carassius RFamide, a novel FMRFa-related peptide, is produced within the retina and involved in retinal information processing in cyprinid fish, Neurosci. Lett., 289, 115-118, 2000
  31. Annelid bioactive peptides: A comparative view, Trends Comp. Biochem. Physiol., 7, 131-141, 2000
  32. The Enterins: A Novel Family of Neuropeptides Isolated from the Enteric Nervous System and CNS of Aplysia, J. Neurosci., 21(20), 8247-8261, 2001
  33. The GGNG-peptide family: annelid myoactive peptides, Perspec. Comp. Endocrinol, 905-909, 2001
  34. A candidate for fish prolactin-releasing peptide isolated from Japanese crucian carp, Recent Advances in Comparative Endocrinology, 29-38, 2001
  35. Purification and some properties of alanine racemase from a bivalve mollusc Corbicula japonica, J. Exp. Zool., 289, 1-9, 2001
  36. NdWFamide: a novel excitatory peptide for the cardiovascular regulation of Aplysia, Peptides, 22, 183-189, 2001
  37. Enhancement of foot formation in Hydra by a novel epitheliopeptide, Hym-323, Development, 128, 437-446, 2001
  38. The enterins inhibit the contractile activity of the anterior aorta of Aplysia kurodai, J .Exp. Biol., 205, 3525-3533, 2002
  39. Structural and functional diversity of the Aplysia Mytilus inhibitory peptide-related peptides, Peptides, 23, 1959-1965, 2002
  40. Aplysia cardioactive peptide (NdWFamide) enhances the L-type Ca2+ current of Aplysia ventricular myocytes, Peptides, 23, 1991-1998, 2002
  41. A novel GGNG-related neuropeptide from the polychaete Perinereis vancaurica, Peptides, 23, 1379-1390, 2002
  42. Distribution and function of an Aplysia cardioexcitatory peptide, NdWFamide, in pulmonate snals, J. Exp. Biol., 24, 1533-1544, 2003
  43. Deamidase inactivates a D-amino acid-containing Aplysia neuropeptide, Cell and tissue research, 24, 45-51, 2003
  44. Identification of a vasopression-like immunoreactive substance in hydra, Peptides, 24, 17-26, 2003
  45. PRQFVamid, a novel pentapeptide identified from the CNS and gut of Aplysia, J. Neurophysiol., 89, 3114-3127, 2003
  46. Distribution of the Aplysia cardiovascular peptide, NdWFamide, in the central and peripheral neurvous systems of Aplysia, Cell Tissue Res., 312, 95-111, 2003
  47. Cloning and characterization of a candidate nutritive glycoprotein from the albumen gland of the freshwater snail, Helisoma duryi (Mollusca : Pulmonata), Invertebr. Biol., 123(1), 83-92, 2004
  48. Peptidergic innervation of the vasoconstrictor muscle of the abdominal aorta in Aplysia kurodai., J. Exp. Biol., 207(Pt 25), 4439-4450, 2004
  49. Purifications, physiological functions and localizations of neuropeptides in a prosobranch gastropod, Thais clavigera, Peptide Sci., 2005, 43-46, 2006
  50. Regulatory actions of neuropeptides and peptide hormones on the reproduction of molluscs, Can. J. Zool., 88, 825-845, 2010
  51. Expression of Asn-d-Trp-Phe-NH2 in the brain of the terrestrial slug Limax valentianus, Comp. Biochem. Physiol., 160B(2-3), 89-93, 2011
  52. Molecular cloning of two distinct precursor genes of NdWFamide, a D-tryptophan-containing neuropeptide of the sea hare, Aplysia kurodai., Peptides, 38(2), 291-301, 2012
  53. Molecular cloning of precursors for TEP-1 and TEP-2: The GGNG peptide-related peptides of a prosobranch gastropod, Thais clavigera., Peptides, 68, 72-82, 2015
  54. Characterization of precursor genes encoding D-tryptophan containing neuropeptide NdWFamide of sea hare Aplysia, Peptide Science, 2013, 439-442, 2014
  55. Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera: The molluscan counterpart of the annelidan GGNG peptides, Peptides, 27, 483-492, 2006
  56. Identification of neuropeptides in gastropod mollusks. - Classical and brand-new approaches –, IOP Conf. Ser.: Earth Environ. Sci., 456, 012001, 2020

Publications such as books

  1. 2006, Invertebrate Neuropeptides and Hormones: Basic knowledge and recent advances, Neuropeptides in Aplysia: Key players for the neural regulation of physiological functions and behavior., Transworld Research Network, 2006, Scholarly Book, Joint work, 英語, Fumihiro Morishita, Yasuo Furukawa, 81-7895-224-6, 276, 38
  2. 2015, Handbook of Hormone, 71 Achatina cardio-excitatory peptide-1, 72 Fulicin, 73 Buccalin, 74 Eisenia inhibitory pentapeptide, 75 GGNG peptide, 81 Egg-laying hormone, 92 Leech osmoregulatory factor, Elsevior, 2015, Scholarly Book, Joint work, English, Minakata, H., Morishita, F.,, 978-0-12-801028-0
  3. 2016, Physiology of Molluscs. A Collection of Selected Reviews., Physiological Functions of Gastropod Peptides and Neurotransmitters., Apple Academic Press, 2016, 11, Scholarly Book, Joint work, English, Mukai ST, Morishita F, 9781771884082, 379-476
  4. 2017, Biological Effects by Organotins, Neuropeptides and their physiological functions in Mollusks., Springer Japan, 2017, Scholarly Book, Joint work, English, Morishita, F, 9784431564492, 254, 167-198

Invited Lecture, Oral Presentation, Poster Presentation

  1. Structures and functions of three peptides identified from a gastropod mollusk, Thais clavigera by the Orbitrap-MS/MS., 2021/06/20, Without Invitation, Japanese
  2. Structure and function of a D-tryptophan-containing neuropeptide in the gastropod mollusks., Fumihiro Morishita, 2019/09/30, With Invitation, English, Faculty of Science and Technology, Maulana Malik Ibrahim State Islamic University, Malang, Indonesia
  3. Identification of Neuropeptides in Gastropod Mollusks. - Classical and Brand-new Approaches -, Fumihiro Morishita1,, Toshio Takahashi, Takehiro Watanabe, Takuya Uto, Kazuyoshi Ukena, Megumi Furumitsu, Toshihiro Horiguchi, 10th International Conference fo Green Technology, 2019/10/02, With Invitation, English, Maulana Malik Ibrahim State Islamic University, Malan, Indonesia
  4. Identification of Neuropeptides in Gastropod Mollusks. - Classical and Brand-new Approaches -, Fumihiro Morishita, 2019/10/01, With Invitation, English, State Health Polytechniue, Malang, Indonesia
  5. Characterization of NdWFamide - A D-tryptophan-containing neuropeptide in Aplysia -, Fumihiro Morishita, 2019/10/04, With Invitation, English, Faculty of Science and Technology, Maulana Malik Ibrahim State Islamic University, Malang, Indonesia
  6. Characterization of a novel neuropeptide, APFSVWAamide, idendified from a prosobranch gastropod, Thais clavigera, 2007, Without Invitation, Japanese
  7. Purifications, Physiological functions and Localizations of Neuropeptides in a Prosobranch Gastropod, Thais clavigera., 2005, Without Invitation, Japanese
  8. Structure and function  of a D-tryptophan-containing neuropeptide in the gastropod mollusk, Aplysia kurodai., Morishita, F., Furukawa, Y., CompBiol2015, 2015/12/11, With Invitation, Japanese, Hiroshima