AKIE HAMAMOTO

Last Updated :2025/07/07

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Assistant Professor
E-mail
ahama32hiroshima-u.ac.jp
Self-introduction
Receptors were long believed to localize only on the cell membrane. I am now focusing on receptors found in specialized sites like primary cilia and cilia-derived extracellular vesicles, aiming to uncover novel signaling mechanisms related to feeding and emotion.

Basic Information

Major Professional Backgrounds

  • 2025/04, 9999
  • 2024/05, 2025/03, Hiroshima University
  • 2023/06, 2024/04, Hiroshima University
  • 2018/02, 2023/03, Gifu University, Faculty of Engineering, Department of Chemistry and Biomolecular Science
  • 2016/04, 2018/01, Kurume University, Institute of Life Science
  • 2015/04, 2016/03
  • 2013/04, 2015/03

Educational Backgrounds

  • Hiroshima University, Graduate School of Integrated Arts and Sciences, 2012/04, 2015/03
  • Hiroshima University, Graduate School of Integrated Arts and Sciences, 2010/04, 2012/03
  • Hiroshima University, School of Integrated Arts and Sciences, Integrated Arts and Sciences, 2006/04, 2010/03

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  2. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  3. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  4. 2025, Liberal Arts Education Program1, 1Term, Experimental Methods and Laboratory Work in Biology I
  5. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  6. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  7. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  8. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  9. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  10. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  11. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  12. 2025, Liberal Arts Education Program1, 3Term, Experimental Methods and Laboratory Work in Biology I
  13. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  14. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  15. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  16. 2025, Liberal Arts Education Program1, 2Term, Experimental Methods and Laboratory Work in Biology II
  17. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  18. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  19. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  20. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  21. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  22. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  23. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  24. 2025, Liberal Arts Education Program1, 4Term, Experimental Methods and Laboratory Work in Biology II
  25. 2025, Undergraduate Education, 2Term, Introduction to Life Sciences
  26. 2025, Undergraduate Education, 2Term, Cell Biology
  27. 2025, Undergraduate Education, 1Term, Laboratory Work in Life Sciences C
  28. 2025, Undergraduate Education, 1Term, Practical Methods in Life Sciences C
  29. 2025, Undergraduate Education, First Semester, Fundamental Laboratory Work in Biology
  30. 2025, Undergraduate Education, First Semester, Fundamental Methodology in Biology

Research Activities

Academic Papers

  1. ★, Correlation between persistent changes in ciliary dynamics in the FrA and depressive-like behavior., Biochemical and biophysical research communications, 762, 151767-151767, 20250406
  2. Ciliary length variations impact cilia-mediated signaling and biological responses., Journal of biochemistry, 20240808
  3. Melanin-concentrating hormone receptor 1 is discarded by exosomes after internalization, Biochemical and Biophysical Research Communications, 710, 149917-149917, 202405
  4. Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities., ACS chemical neuroscience, 20230427
  5. Adenostemmoic acid B suppresses NO production by downregulating the expression and inhibiting the enzymatic activity of iNOS, Phytochemistry Letters, 49, 131-137, 202206
  6. Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones, ACS Chemical Neuroscience, 13(7), 1055-1064, 20220406
  7. Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan, Journal of Natural Medicines, 20210912
  8. Zebrafish as a new model for rhododendrol-induced leukoderma., Pigment cell & melanoma research, 20210726
  9. Thioxothiazolidin Derivative, 4-OST, Inhibits Melanogenesis by Enhancing the Specific Recruitment of Tyrosinase-containing Vesicles to Lysosome, Journal of Cellular Biochemistry, 202101
  10. Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode., Nature communications, 11(1), 4160-4160, 20200819
  11. The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level., Antioxidants (Basel, Switzerland), 9(8), 20200808
  12. Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia., Microscopy (Oxford, England), 20200706
  13. Mouse model of metformin-induced diarrhea., BMJ open diabetes research & care, 8(1), 202003
  14. The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays., Foods (Basel, Switzerland), 9(1), 20200109
  15. New Deletions in the Hermansky-Pudlak Syndrome Type 5 Gene in a Japanese Patient, Reports, 2(2), 5, 201905
  16. Azepine derivative T4FAT, a new copper chelator, inhibits tyrosinase., Biochemical and biophysical research communications, 509(1), 209-215, 20190129
  17. Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1., General and comparative endocrinology, 253, 44-52, 20171101
  18. Ghrelin O-acyltransferase (GOAT), a specific enzyme that modifies ghrelin with a medium-chain fatty acid., Journal of biochemistry, 160(4), 189-194, 201610
  19. Modulation of primary cilia length by melanin-concentrating hormone receptor 1., Cellular signalling, 28(6), 572-84, 201606
  20. Dimerization of melanocortin receptor 1 (MC1R) and MC5R creates a ligand-dependent signal modulation: Potential participation in physiological color change in the flounder., General and comparative endocrinology, 230-231, 103-9, 20160501
  21. Involvement of melanin-concentrating hormone 2 in background color adaptation of barfin flounder Verasper moseri., General and comparative endocrinology, 214, 140-8, 20150401
  22. Identification of amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1., Cellular signalling, 27(4), 818-27, 201504
  23. Molecular cloning, expression, and signaling pathway of four melanin-concentrating hormone receptors from Xenopus tropicalis., General and comparative endocrinology, 212, 114-23, 20150201
  24. Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1., General and comparative endocrinology, 188, 159-65, 20130701
  25. Mutation of Phe318 within the NPxxY(x)(5,6)F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity., Frontiers in endocrinology, 3, 147-147, 2012
  26. Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2., Regulatory peptides, 169(1-3), 6-12, 20110808

External Funds

Acceptance Results of Competitive Funds

  1. 2025
  2. 2025/04, 2028/03
  3. 2021/04/01, 2024/03/31
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  4. Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Development new materials for pneumonia, 2020/10/27, 2024/03/31
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  5. 2021/12, 2022/12
  6. 2022/04
  7. 2020/11, 2022/03
  8. 2019, 2022
  9. 2018, 2022
  10. 2020/12, 2021/03
  11. 2018, 2019
  12. 2018, 2019
  13. 2016, 2018
  14. 2013, 2015
  15. 2012, 2013