HISAKO FURUSHO
Last Updated :2024/05/15
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
- E-mail
- furusyou-1217hiroshima-u.ac.jp
Basic Information
Major Professional Backgrounds
- 2007/04/01, 2008/03/31, Hiroshima University Hospital, Hospital, Clinical Resident
- 2008/04/01, 2009/03/31, Hiroshima University Hospital, Hospital, Clinical Fellow
- 2009/05/07, 2010/01/12, Hiroshima University, Gender Equality Promotion Office
- 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor
Educational Backgrounds
- Hiroshima University, Japan, 2008/04, 2012/03
- Hiroshima University, Japan, 2001/04, 2007/03
Academic Degrees
Educational Activity
- [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences
Research Fields
- Medicine,dentistry, and pharmacy;Dentistry;Pathobiological dentistry / Dental radiology
Research Keywords
- Preterm birth
- P.gingivalis
- NASH
- TLR
Affiliated Academic Societies
- The Japanese Society of Oral Pathology
- The Japanese Society of Pathology
- International Association for Dental Research
- Japanese Association of Oral Biology
Educational Activity
Course in Charge
- 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
- 2024, Undergraduate Education, 3Term, Basic Oral Pathology I
- 2024, Undergraduate Education, 4Term, Basic Oral Pathology II
- 2024, Undergraduate Education, 1Term, Slide Practice for Oral Pathology I
- 2024, Undergraduate Education, 2Term, Slide Practice for Oral Pathology II
- 2024, Undergraduate Education, 2Term, Basic and clinical integrated theory
- 2024, Undergraduate Education, First Semester, Dental Research Practices III
- 2024, Undergraduate Education, First Semester, Dental Research Practices IV (Bacteriology)
- 2024, Undergraduate Education, 2Term, Pathology and Oral Pathology
- 2024, Undergraduate Education, Second Semester, Practice on Basic Dental Sciences
- 2024, Undergraduate Education, 2Term, Pathology and Oral Pathology
Research Activities
Academic Papers
- Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring, FRONTIERS IN PEDIATRICS, 11, 20230811
- Equisetum arvense Inhibits Alveolar Bone Destruction in a Rat Model with Lipopolysaccharide (LPS)-Induced Periodontitis, INTERNATIONAL JOURNAL OF DENTISTRY, 2022, 20221230
- Imipramine prevents Porphyromonas gingivalis lipopolysaccharide- induced microglial neurotoxicity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 634, 92-99, 20221217
- A case of primary neuroendocrine carcinoma of the mandibular gingiva treated using multimodal therapy, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 35(1), 60-66, 202301
- Progesterone Suppresses Uterine Contraction by Reducing Odontogenic Porphyromonas gingivalis Induced Chronic Inflammation in Mice, BIOMOLECULES, 12(8), 202208
- Association between left atrial appendage fibrosis and thrombus formation: A histological approach, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 33(4), 677-687, 202204
- Oral Administration of Prostaglandin E-2-Specific Receptor 4 Antagonist Inhibits Lipopolysaccharide-Induced Osteoclastogenesis in Rat Periodontal Tissue, JOURNAL OF PERIODONTOLOGY, 83(4), 506-513, 201204
- IL-17 Receptor A Signaling Is Protective in Infection-Stimulated Periapical Bone Destruction, JOURNAL OF IMMUNOLOGY, 191(4), 1785-1791, 20130815
- Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48(11), 1259-1270, 201311
- Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice, PLOS ONE, 9(10), 20141021
- Dental Infection of Porphyromonas gingivalis Induces Preterm Birth in Mice, PLOS ONE, 10(8), 20150831
- Osteodystrophy in Cholestatic Liver Diseases Is Attenuated by Anti-gamma-Glutamyl Transpeptidase Antibody, PLOS ONE, 10(9), 20150929
- Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by -Adrenergic Receptors in Brown Adipocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8), 4185-4196, 20160219
- Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders, CURRENT PHARMACEUTICAL DESIGN, 22(15), 2204-2215, 2016
- Enhanced Expression of Contractile-Associated Proteins and Ion Channels in Preterm Delivery Model Mice With Chronic Odontogenic Porphyromonas Gingivalis Infection, REPRODUCTIVE SCIENCES, 23(7), 838-846, 201607
- Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice, ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 299(9), 1281-1292, 201609
- Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma, PLOS ONE, 12(11), 20171117
- Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease, JOURNAL OF GASTROENTEROLOGY, 53(2), 269-280, 201802
- Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis, SCIENTIFIC REPORTS, 8, 20180212
- Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss, INTERNATIONAL JOURNAL OF ORAL SCIENCE, 10, 20180413
- Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4, JOURNAL OF DENTAL RESEARCH, 98(1), 117-125, 201901
- Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice, JOURNAL OF ENDODONTICS, 45(2), 181-188, 201902
- Fetal Membrane Inflammation Induces Preterm Birth Via Toll-Like Receptor 2 in Mice With Chronic Gingivitis, REPRODUCTIVE SCIENCES, 26(7), 869-878, 201907
- Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation, SCIENTIFIC REPORTS, 10(1), 20200305
- Immunomodulation Mediated by Azithromycin in Experimental Periapical Inflammation, JOURNAL OF ENDODONTICS, 46(11), 1648-1654, 202011
- Anti-inflammatory effect of glycyrrhizin with Equisetum arvense extract, ODONTOLOGY, 109(2), 464-473, 202104
- Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 32(5), 1240-1250, 202105
- External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
- Elimination of Porphyromonas gingivalis inhibits liver fibrosis and inflammation in NASH, JOURNAL OF CLINICAL PERIODONTOLOGY, 48(10), 1367-1378, 202110
Invited Lecture, Oral Presentation, Poster Presentation
- A case of giant odontoma of mandible with juvenile psammoma type ossifying fibroma of maxilla, Aki Satou, Matsumura T, Nakano M, Sawaki K, Yoshioka Y, Akashi S, Furusho H, Miyuachi M, Mizukawa N, Iida S, the 67th Congress of the Japanese Society of Oral and Maxillofacial Surgeons, 2022/11/06, Without Invitation, Japanese
- Impact of maternal Porphyromonas gingivalis infection on brain of offspring, Eri Ishida, 2022/09/19, Without Invitation, Japanese, Tokushima
- COR588 treatment prevents preterm birth induced by P. gingivalis-odontogenic infection, Florian E, Furusho H, Miyauchi M, 2022 IADR/APR General Session & Exhibition, 2022/06/25, Without Invitation, English
- Impact of maternal Porphyromonas gingivalis infection on brain of offspring, Eri Iashida, Furusho H, Miyauchi M, 2022 IADR/APR General Session & Exhibition/ the 70th Annual Meeting of JADR, 2022/06/25, Without Invitation, English, Web
- The inhibitory effects of gingipain inhibitor X on preterm birth caused by Porphyromonas gingivalis odontogenic infection, Nguyen HH, Renn TY, Nose M, Yamane S, Suenaka S, Nakajima A, Pham TP, Furusho H, Miyauchi M, 2022/06/11, Without Invitation, English
- Odontogenic infection of Porphyromonas gingivalis induces pathological progression of non-alcoholic
steatohepatitis (NASH)., Furusho H, Miuauchi M, Takata T., 5th Asia Topic Conference, 2014/10/21, Without Invitation, English
- The effects of Porphyromonas gingivalis infection on hepatocytes., Sakamoto S, Furusho H, Nagasaki A, Miyauchi M, Hisatsune J, Sugai M, Tahara H, and Takata T., 62nd Japanese association of dental research, 2014/12/05, Without Invitation, Japanese
- Dental infection of Porphyromonas gingivalis (P.g.) exacerbates progression of non-alcoholic steatohepatitis –Effects of P.g. infection and P.g.-LPS on Hepatocytes, Miyauchi M, Furusho H, Nagasaki A, Takata T., 93rd General Session & Exhibition of the International Association for Dental Research, 2015/03/14, Without Invitation, English, the International Association for Dental Research, Boston, USA
- TLR2 plays a key role in P.gingivalis-induced NASH progeression., Furusho H, Miyauchi M, Nagasaki A, Sakamoto S, Takata T., 6th Hiroshima Conference on Education and Science in Dentistry, 2015/10/24, Without Invitation, English, Hiroshima Conference on Education and Science in Dentistry, Hiroshima. Japan
- Dental Infection of Porphyromonas gingivalis Exacerbates Pathological Progression of Non-Alcoholic Steatohepatitis (NASH)., Miyauchi M, Furusho H, Nagasaki A, Sakamoto S, Ouhara K, Kurihara H, Takata T., 6th Hiroshima Conference on Education and Science in Dentistry, 2015/10/23, Without Invitation, English
- TLR2 plays a key role in P.gingivalis-induced NASH progeression, Furusho H, Miyauchi M, Nagasaki A, Sakamoto S, Takata T., 2015/10/30, Without Invitation, English
- Key roles of TLR2 in NASH progression by P.g.-odontogenic infection, Hisako Furusho, Atsuhiro Nagasaki, Shinnichi Sakamoto, Mutsumi Miyauchi, Takashi Takata., 64th Japanese Association for Dental Research(JADR) annual meeting, 2016/06/25, Without Invitation, English, Seoul, Korea
- Galectin-3 is possible predictive / diagnostic biomarker of spontaneous preterm birth caused by placental infection., Chou K., Miyauchi M., Furusho H., Sakamoto S., Takata T, 2017/11/17, Without Invitation, English
Awards
- 2015/10/25, Poster Award, Hiroshima Conference
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, 2014, 2015
- KAKENHI, Elucidation of of non-alcoholic steatohepatitis exacerbation mechanism by dental infection and effects of dental treatment, 2012, 2013
- KAKENHI, 2013, 2015
- KAKENHI, 2016, 2018