HISAKO FURUSHO

Last Updated :2025/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Dentistry & Oral Health Sciences), Assistant Professor
E-mail
furusyou-1217hiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2007/04/01, 2008/03/31, Hiroshima University Hospital, Hospital, Clinical Resident
  • 2008/04/01, 2009/03/31, Hiroshima University Hospital, Hospital, Clinical Fellow
  • 2009/05/07, 2010/01/12, Hiroshima University, Gender Equality Promotion Office
  • 2012/04/01, 2019/03/31, Hiroshima University, Institute of Biomedical & Health Sciences, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Japan, 2008/04, 2012/03
  • Hiroshima University, Japan, 2001/04, 2007/03

Academic Degrees

  • Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Dentistry : Program of Dentistry : Dentistry
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Dental Sciences

In Charge of Primary Major Programs

  • Dentistry

Research Fields

  • Medicine,dentistry, and pharmacy;Dentistry;Pathobiological dentistry / Dental radiology

Research Keywords

  • Preterm birth
  • P.gingivalis
  • NASH
  • TLR

Affiliated Academic Societies

Educational Activity

Course in Charge

  1. 2025, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
  2. 2025, Undergraduate Education, 4Term, Life Science
  3. 2025, Undergraduate Education, 3Term, Basic Oral Pathology I
  4. 2025, Undergraduate Education, 4Term, Basic Oral Pathology II
  5. 2025, Undergraduate Education, 1Term, Slide Practice for Oral Pathology I
  6. 2025, Undergraduate Education, 2Term, Slide Practice for Oral Pathology II
  7. 2025, Undergraduate Education, 1Term, Topics in Dental Research I
  8. 2025, Undergraduate Education, 2Term, Basic and Clinical Integrated Theory
  9. 2025, Undergraduate Education, 2Term, Pathology and Oral Pathology
  10. 2025, Undergraduate Education, Second Semester, Practice on Basic Dental Sciences
  11. 2025, Undergraduate Education, 2Term, Pathology and Oral Pathology

Research Activities

Academic Papers

  1. Oral dysbiosis and systemic diseases, FRONTIERS IN DENTAL MEDICINE, 3, 20220811
    Link to Paper Search Results by DOI
  2. Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation Histological Evaluation of Left Atrial Appendages, JACC-CLINICAL ELECTROPHYSIOLOGY, 9(1), 43-53, 202301
    Link to Paper Search Results by DOI
  3. Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring, FRONTIERS IN PEDIATRICS, 11, 20230811
    Link to Paper Search Results by DOI
  4. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation, SCIENTIFIC REPORTS, 13(1), 20230608
    Link to Paper Search Results by DOI
  5. Equisetum arvense Inhibits Alveolar Bone Destruction in a Rat Model with Lipopolysaccharide (LPS)-Induced Periodontitis, INTERNATIONAL JOURNAL OF DENTISTRY, 2022, 20221230
    Link to Paper Search Results by DOI
  6. Imipramine prevents Porphyromonas gingivalis lipopolysaccharide- induced microglial neurotoxicity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 634, 92-99, 20221217
    Link to Paper Search Results by DOI
  7. A case of primary neuroendocrine carcinoma of the mandibular gingiva treated using multimodal therapy, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 35(1), 60-66, 202301
    Link to Paper Search Results by DOI
  8. Progesterone Suppresses Uterine Contraction by Reducing Odontogenic Porphyromonas gingivalis Induced Chronic Inflammation in Mice, BIOMOLECULES, 12(8), 202208
    Link to Paper Search Results by DOI
  9. Association between left atrial appendage fibrosis and thrombus formation: A histological approach, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 33(4), 677-687, 202204
    Link to Paper Search Results by DOI
  10. Oral Administration of Prostaglandin E-2-Specific Receptor 4 Antagonist Inhibits Lipopolysaccharide-Induced Osteoclastogenesis in Rat Periodontal Tissue, JOURNAL OF PERIODONTOLOGY, 83(4), 506-513, 201204
    Link to Paper Search Results by DOI
  11. IL-17 Receptor A Signaling Is Protective in Infection-Stimulated Periapical Bone Destruction, JOURNAL OF IMMUNOLOGY, 191(4), 1785-1791, 20130815
    Link to Paper Search Results by DOI
  12. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice, JOURNAL OF GASTROENTEROLOGY, 48(11), 1259-1270, 201311
    Link to Paper Search Results by DOI
  13. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice, PLOS ONE, 9(10), 20141021
    Link to Paper Search Results by DOI
  14. Dental Infection of Porphyromonas gingivalis Induces Preterm Birth in Mice, PLOS ONE, 10(8), 20150831
    Link to Paper Search Results by DOI
  15. Osteodystrophy in Cholestatic Liver Diseases Is Attenuated by Anti-gamma-Glutamyl Transpeptidase Antibody, PLOS ONE, 10(9), 20150929
    Link to Paper Search Results by DOI
  16. Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by -Adrenergic Receptors in Brown Adipocytes, JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8), 4185-4196, 20160219
    Link to Paper Search Results by DOI
  17. Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders, CURRENT PHARMACEUTICAL DESIGN, 22(15), 2204-2215, 2016
    Link to Paper Search Results by DOI
  18. Enhanced Expression of Contractile-Associated Proteins and Ion Channels in Preterm Delivery Model Mice With Chronic Odontogenic Porphyromonas Gingivalis Infection, REPRODUCTIVE SCIENCES, 23(7), 838-846, 201607
    Link to Paper Search Results by DOI
  19. Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice, ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 299(9), 1281-1292, 201609
    Link to Paper Search Results by DOI
  20. Roles of VEGF-Flt-1 signaling in malignant behaviors of oral squamous cell carcinoma, PLOS ONE, 12(11), 20171117
    Link to Paper Search Results by DOI
  21. Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease, JOURNAL OF GASTROENTEROLOGY, 53(2), 269-280, 201802
    Link to Paper Search Results by DOI
  22. Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis, SCIENTIFIC REPORTS, 8, 20180212
    Link to Paper Search Results by DOI
  23. Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss, INTERNATIONAL JOURNAL OF ORAL SCIENCE, 10, 20180413
    Link to Paper Search Results by DOI
  24. Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4, JOURNAL OF DENTAL RESEARCH, 98(1), 117-125, 201901
    Link to Paper Search Results by DOI
  25. Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice, JOURNAL OF ENDODONTICS, 45(2), 181-188, 201902
    Link to Paper Search Results by DOI
  26. Fetal Membrane Inflammation Induces Preterm Birth Via Toll-Like Receptor 2 in Mice With Chronic Gingivitis, REPRODUCTIVE SCIENCES, 26(7), 869-878, 201907
    Link to Paper Search Results by DOI
  27. Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation, SCIENTIFIC REPORTS, 10(1), 20200305
    Link to Paper Search Results by DOI
  28. Immunomodulation Mediated by Azithromycin in Experimental Periapical Inflammation, JOURNAL OF ENDODONTICS, 46(11), 1648-1654, 202011
    Link to Paper Search Results by DOI
  29. Anti-inflammatory effect of glycyrrhizin with Equisetum arvense extract, ODONTOLOGY, 109(2), 464-473, 202104
    Link to Paper Search Results by DOI
  30. Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 32(5), 1240-1250, 202105
    Link to Paper Search Results by DOI
  31. External cervical resorption detected via cone-beam computed tomography in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease: A case report, CLINICAL CASE REPORTS, 9(7), 202107
    Link to Paper Search Results by DOI
  32. Elimination of Porphyromonas gingivalis inhibits liver fibrosis and inflammation in NASH, JOURNAL OF CLINICAL PERIODONTOLOGY, 48(10), 1367-1378, 202110
    Link to Paper Search Results by DOI

Publications such as books

  1. 2024/04/22, Endotoxin and Innate Immunity, The mechanism of inhibition of alveolar bone destruction by Equisetum arvense extract in a rat model of LPS-induced periodontitis, Koryosya, 2024, 4, Scholarly Book, Joint work, 日本語, Shiba F, Furusho H, Miyauchi M, 2434-1177, 33, 5

Invited Lecture, Oral Presentation, Poster Presentation

  1. A case report of Cemento-ossifying fibroma and odontoma associated with Sturge-Weber syndrome in the jaw, Furusho H, Satou A, Matsumura T, Nakano M, Sawaki K, Yoshioka Y, Akashi S, Mizukawa N, Iida S, Kakimoto N, Miyauchi M, the 21st International congress of Oral Pathology and Medeicine, 2023/08/18, Without Invitation, English, International Association of Oral and Maxillofacial Pathologists, Taipei
  2. A case of giant odontoma of mandible with juvenile psammoma type ossifying fibroma of maxilla, Aki Satou, Matsumura T, Nakano M, Sawaki K, Yoshioka Y, Akashi S, Furusho H, Miyuachi M, Mizukawa N, Iida S, the 67th Congress of the Japanese Society of Oral and Maxillofacial Surgeons, 2022/11/06, Without Invitation, Japanese
  3. Impact of maternal Porphyromonas gingivalis infection on brain of offspring, Eri Ishida, 2022/09/19, Without Invitation, Japanese, Tokushima
  4. COR588 treatment prevents preterm birth induced by P. gingivalis-odontogenic infection, Florian E, Furusho H, Miyauchi M, 2022 IADR/APR General Session & Exhibition, 2022/06/25, Without Invitation, English
  5. Impact of maternal Porphyromonas gingivalis infection on brain of offspring, Eri Iashida, Furusho H, Miyauchi M, 2022 IADR/APR General Session & Exhibition/ the 70th Annual Meeting of JADR, 2022/06/25, Without Invitation, English, Web
  6. The inhibitory effects of gingipain inhibitor X on preterm birth caused by Porphyromonas gingivalis odontogenic infection, Nguyen HH, Renn TY, Nose M, Yamane S, Suenaka S, Nakajima A, Pham TP, Furusho H, Miyauchi M, 2022/06/11, Without Invitation, English
  7. Odontogenic infection of Porphyromonas gingivalis induces pathological progression of non-alcoholic steatohepatitis (NASH)., Furusho H, Miuauchi M, Takata T., 5th Asia Topic Conference, 2014/10/21, Without Invitation, English
  8. The effects of Porphyromonas gingivalis infection on hepatocytes., Sakamoto S, Furusho H, Nagasaki A, Miyauchi M, Hisatsune J, Sugai M, Tahara H, and Takata T., 62nd Japanese association of dental research, 2014/12/05, Without Invitation, Japanese
  9. Dental infection of Porphyromonas gingivalis (P.g.) exacerbates progression of non-alcoholic steatohepatitis –Effects of P.g. infection and P.g.-LPS on Hepatocytes, Miyauchi M, Furusho H, Nagasaki A, Takata T., 93rd General Session & Exhibition of the International Association for Dental Research, 2015/03/14, Without Invitation, English, the International Association for Dental Research, Boston, USA
  10. TLR2 plays a key role in P.gingivalis-induced NASH progeression., Furusho H, Miyauchi M, Nagasaki A, Sakamoto S, Takata T., 6th Hiroshima Conference on Education and Science in Dentistry, 2015/10/24, Without Invitation, English, Hiroshima Conference on Education and Science in Dentistry, Hiroshima. Japan
  11. Dental Infection of Porphyromonas gingivalis Exacerbates Pathological Progression of Non-Alcoholic Steatohepatitis (NASH)., Miyauchi M, Furusho H, Nagasaki A, Sakamoto S, Ouhara K, Kurihara H, Takata T., 6th Hiroshima Conference on Education and Science in Dentistry, 2015/10/23, Without Invitation, English
  12. TLR2 plays a key role in P.gingivalis-induced NASH progeression, Furusho H, Miyauchi M, Nagasaki A, Sakamoto S, Takata T., 2015/10/30, Without Invitation, English
  13. Key roles of TLR2 in NASH progression by P.g.-odontogenic infection, Hisako Furusho, Atsuhiro Nagasaki, Shinnichi Sakamoto, Mutsumi Miyauchi, Takashi Takata., 64th Japanese Association for Dental Research(JADR) annual meeting, 2016/06/25, Without Invitation, English, Seoul, Korea
  14. Galectin-3 is possible predictive / diagnostic biomarker of spontaneous preterm birth caused by placental infection., Chou K., Miyauchi M., Furusho H., Sakamoto S., Takata T, 2017/11/17, Without Invitation, English

Awards

  1. 2015/10/25, Poster Award, Hiroshima Conference

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2015
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  2. KAKENHI, Elucidation of of non-alcoholic steatohepatitis exacerbation mechanism by dental infection and effects of dental treatment, 2012, 2013
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  3. KAKENHI, 2013, 2015
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  4. KAKENHI, 2016, 2018