YUTAKA KIKUCHI

Last Updated :2021/07/02

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Professor
E-mail
yutakahiroshima-u.ac.jp

Basic Information

Academic Degrees

  • Doctor of Agriculture, The University of Tokyo

Research Fields

  • Biological Sciences;Oncology;Tumor biology
  • Biological Sciences;Genome science;Genome biology
  • Informatics;Frontiers of informatics;Life / Health / Medical informatics

Research Keywords

  • cancer, epigenetics, bioinformatics, imaging

Affiliated Academic Societies

  • Japan Society for Cell Biology
  • The Molecular Biology Society of Japan
  • The Biophysical Society of Japan

Educational Activity

Course in Charge

  1. 2021, Liberal Arts Education Program1, 1Term, Fundamentals of Biology
  2. 2021, Liberal Arts Education Program1, 3Term, Introduction to Biology
  3. 2021, Undergraduate Education, 4Term, Introduction to Biological Sciences B
  4. 2021, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  5. 2021, Undergraduate Education, Second Semester, English Seminar on Biological Science
  6. 2021, Undergraduate Education, 2Term, Advanced Biology
  7. 2021, Undergraduate Education, 2Term, Developmental Biology B
  8. 2021, Undergraduate Education, Second Semester, Seminar for Developmental Biology
  9. 2021, Undergraduate Education, First Semester, Special Study for Graduation
  10. 2021, Undergraduate Education, Second Semester, Special Study for Graduation
  11. 2021, Undergraduate Education, First Semester, Practice for Fundamental Biology III
  12. 2021, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  13. 2021, Undergraduate Education, 4Term, Biological Informatics
  14. 2021, Graduate Education (Master's Program) , First Semester, Special Research for Thesis
  15. 2021, Graduate Education (Master's Program) , Second Semester, Special Research for Thesis
  16. 2021, Graduate Education (Master's Program) , First Semester, Developmental Biology (Seminar)
  17. 2021, Graduate Education (Master's Program) , Second Semester, Developmental Biology (Seminar)
  18. 2021, Graduate Education (Doctoral Program) , First Semester, Special Research for Biological Science
  19. 2021, Graduate Education (Doctoral Program) , Second Semester, Special Research for Biological Science
  20. 2021, Graduate Education (Doctoral Program) , First Semester, Developmental Biology (Seminar)
  21. 2021, Graduate Education (Doctoral Program) , Second Semester, Developmental Biology (Seminar)
  22. 2021, Graduate Education (Doctoral Program) , First Semester, Seminar in Global Biological Science
  23. 2021, Graduate Education (Doctoral Program) , Second Semester, Seminar in Global Biological Science
  24. 2021, Graduate Education (Master's Program) , 2Term, societal implementation of life science
  25. 2021, Graduate Education (Master's Program) , 2Term, Seminar for Advanced Research in Basic Biology A
  26. 2021, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology B
  27. 2021, Graduate Education (Master's Program) , 1Term, Exercises in Basic Biology A
  28. 2021, Graduate Education (Master's Program) , 2Term, Exercises in Basic Biology A
  29. 2021, Graduate Education (Master's Program) , 3Term, Exercises in Basic Biology B
  30. 2021, Graduate Education (Master's Program) , 4Term, Exercises in Basic Biology B
  31. 2021, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  32. 2021, Graduate Education (Master's Program) , 4Term, Cell Dynamics and Genomics
  33. 2021, Graduate Education (Master's Program) , 2Term, Seminar for Advanced Research in Basic Biology C
  34. 2021, Graduate Education (Master's Program) , 3Term, Seminar for Advanced Research in Basic Biology D
  35. 2021, Graduate Education (Doctoral Program) , 2Term, Seminar for Advanced Research in Basic Biology E
  36. 2021, Graduate Education (Doctoral Program) , 3Term, Seminar for Advanced Research in Basic Biology F
  37. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  38. 2021, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  39. 2021, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  40. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  41. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  42. 2021, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E

Research Activities

Academic Papers

  1. ★, 3D in vitro co-culture disc for spatiotemporal image analysis of cancer-stromal cell interaction., Biomaterials Science, 9, 4448-4458, 2021, June, 15
  2. Anticancer polymers designed for killing dormant prostate cancer cells., Scientific Reports, 9, 1096, 2019, January, 31
  3. Unusual light-reflecting pigment cells appear in the Xenopus neural tube culture system in the presence of guanosine., Tissue and Cell, 54, 55-58, 20180809
  4. ★, Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration., Scientific Reports, 8(1), 8278, 20180329
  5. The N-terminal domain of gastrulation brain homeobox 2 (Gbx2) is required for iridophore specification in zebrafish., Biochemical and Biophysical Research Communications, 502, 104-109, 20180701
  6. ★, Nuclear movement regulated by non-Smad Nodal signaling via JNK is associated with Smad signal transduction during zebrafish endoderm specification., Development, 144(21), 4015-4025, 20171101
  7. A limited role for zebrafish Planar Cell Polarity during early endoderm morphogenesis., Biology Open, 6, 531-539, 201703
  8. Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle., Nature Communications, 8, 14664, 201703
  9. Magnetically tunable control of light reflection in an unusual optical protein of squid., AIP ADVANCES, 7, 056722-056722-6, 201702
  10. Histone H3 lysine 27 trimethylation leads to loss of mesendodermal competence during gastrulation in zebrafish ectodermal cells., Zoological Science, 34, 64-71, 201702
  11. Temporal effects of Notch signaling and potential cooperation with multiple downstream effectors on adenohypophysis cell specification in zebrafish, Gnens to Cells, 21(5), 492-504, 201603
  12. No Evidence for AID/MBD4-Coupled DNA Demethylation in Zebrafish Embryos, PLOS ONE, 9(12), e114816, 20141223
  13. ★, Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Developmental Biology, 14, 42, 20141206
  14. ★, Nipbl and Mediator Cooperatively Regulate Gene Expression to Control Limb Development, PLOS Genetics, 10(9), e1004671, 201409
  15. Expression patterns of dnmt3aa, dnmt3ab, and dnmt4 during development and fin regeneration in zebrafish, Gene Expression Patterns, 14(2), 105-110, 201403
  16. Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging, Age, 36(1), 103-115, 201402
  17. ★, Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish, Stem Cells and Development, 22(18), 2532-2542, 20130915
  18. ★, Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin, Epigenetics, 8(9), 899-906, 20130901
  19. DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish, PLOS ONE, 7(3), 20120319
  20. Zebrafish Dmrta2 regulates neurogenesis in the telencephalon, Genes to Cells, 16(11), 1097-1109, 201111
  21. Expression patterns of lgr4 and lgr6 during zebrafish development, Gene Expression Patterns, 11(7), 378-383, 201110
  22. Cyp26 enzymes function in endoderm to regulate pancreatic field size, Proceedings of the National Academy of Sciences of the United States of America, 106(19), 7864-7869, 20090512
  23. ★, Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation, Development, 135(15), 2521-2529, 20080801
  24. Identification and characterization of nucleoplasmin 3 as a histone-binding protein in embryonic stem cells, Development Growth & Differentiation, 50(5), 307-320, 200806
  25. Translational enhancement of recombinant protein synthesis in transgenic silkworms by a 5 '-untranslated region of polyhedrin gene of Bombyx mori Nucleopolyhedrovirus, Journal of Bioscience and Bioengineering, 105(6), 595-603, 200806
  26. Extensive expansion and diversification of the chemokine gene family in zebrafish: Identification of a novel chemokine subfamily CX, BMC Genomics, 9, 20080515
  27. Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation., Developmental Biology, 12-22, 200802
  28. Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal., Developmental Dynamics, 236, 564-571, 200702
  29. Fgf signaling negatively regulates Nodal-dependent endoderm induction in zebrafish., Developmental biology, 300(2), 200612
  30. The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish., Development, 133(20), 4063-4072, 200610
  31. ★, Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish., Developmental Cell, 9, 523-533, 200510
  32. Notch signaling can regulate endoderm formation in zebrafish., Developmental Dynamics, 229(4), 756-762, 200404
  33. ★, The POU domain protein spg (pou2/Oct4) is essential for endoderm formation in cooperation with the HMG domain protein casanova., Developmental Cell, 6, 91-101, 200401
  34. Molecular diversity in zebrafish NCAM family: three members with different VASE usage and distinct localization., Molecular and Cellular Neuroscience, 18, 119-130, 200107
  35. ★, casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish., 15, 1493-1505, 200106
  36. Functional repression of Islet-2 by disruption of complex with Ldb impairs pripheral axonal outgrowth in embryonic zebrafish., Neuron, 30, 423-436, 200103
  37. Multiple roles for Gata5 in zebrafish endoderm formation., Development, 128, 125-135, 200101
  38. ★, The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. , Genes & Development, 14, 1279-1289, 200005
  39. Two zebrafish (Danio rerio) antizymes with different expression and activities., Biochemical Journal, 345, 99-106, 200001
  40. Compartmentalized expression of zebrafish ten-m3 and ten-m5, homologues of the Drosophila tenm/odd Oz gene, in the central nervous system., Mechanisms of Development, 87, 223-227, 199909
  41. ★, Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the Islet-4 LIM/homeodomain protein., Neuron, 18, 369-382, 199703
  42. Mermaid : A family of short interspersed repetitive elements widespread in vertebrates., Biochemical and Biophysical Research Communications, 220, 226-232, 199603
  43. Mermaid, A family of short interspersed repetitive element, is useful for the zebrafish genome mapping., Biochemical and Biophysical Research Communications, 220, 233-237, 199603
  44. Pseudomonas fluorescens KKL101, a benzoic acid degrader in a mixed culture that degrades biphenyl and polychlorinated biphenyls., Bioscience, Biotechnology, and Biochemistry, 59, 2303-2304, 199512
  45. Identification of the bphA and bphB genes of Pseudomonas sp. strain KKS102 involved in degradation of biphenyl and polychlorinated biphenyls., Biochemical and Biophysical Research Communications, 202, 850-856, 199407
  46. ★, Identification of the bphA4 gene encoding ferredoxin reductase involved in biphenyl and polychlorinated biphenyl degradation in Pseudomonas sp. strain KKS102., Journal of Bacteriology, 176, 1689-1694, 199403
  47. ★, Nucleotide sequence and functional analysis of the meta-cleavage pathway involved in biphenyl and polychlorinated biphenyl degradation in Pseudomonas sp. strain KKS102., Journal of Bacteriology, 176, 4269-4276, 199407