RYUUJI NAKAMURA

Last Updated :2025/08/06

Affiliations, Positions
Hiroshima University Hospital, Associate Professor/Lecturer
E-mail
r-nacamurahiroshima-u.ac.jp
Self-introduction
We are developing a system that measures the autonomic nervous function during surgery. This system can answer the questions such as "is the patient painful?" and "is the amount of analgesic enough?".

Basic Information

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Boundary medicine;Pain science

Research Keywords

  • Arterial inpedance

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Systemic Disease Control
  2. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  4. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Anesthesiology and Critical Care
  5. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Anesthesiology and Critical Care
  6. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Anesthesiology and Critical Care
  7. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Anesthesiology and Critical Care
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Palliative and Supportive Care for Cancer Patients
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Palliative and Supportive Care for Cancer Patients
  10. 2025, Graduate Education (Doctoral Program) , First Semester, Palliative Care Conference

Research Activities

Academic Papers

  1. Comparison between single bolus dose administration and continuous infusion of remimazolam for general anesthesia induction in non-cardiac surgery: a single-center prospective randomized controlled trial, BMC ANESTHESIOLOGY, 25(1), 20250402
    Link to Paper Search Results by DOI
  2. Impact of proficiency in the transcatheter aortic valve implantation procedure on clinical outcomes: a single center retrospective study, BMC ANESTHESIOLOGY, 24(1), 20240621
    Link to Paper Search Results by DOI
  3. Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome, PEDIATRICS INTERNATIONAL, 59(1), 97-98, 2017
  4. Paravertebral block catheter breakage by electrocautery during thoracic surgery, JOURNAL OF ANESTHESIA, 31(3), 463-466, 2017
  5. Alteration of Arterial Mechanical Impedance Greater than that of Photoplethysmogram and Laser Doppler Flowmetry during Endoscopic Thoracic Sympathectomy, JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 37(6), 820-825, 2017
  6. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model, SCIENTIFIC REPORTS, 8, 2018
  7. A new arterial mechanical property indicator reflecting differences in invasive stimulus intensity induced by alteration of remifentanil concentration during laryngoscopy, MINERVA ANESTESIOLOGICA, 84(3), 311-318, 2018
  8. Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation, SCIENTIFIC REPORTS, 8, 2018
  9. Postoperative thoracic and low back pain following endovascular aortic repair associated with stenting location, JOURNAL OF ANESTHESIA, 33(1), 75-79, 2019
  10. Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function, SCIENTIFIC REPORTS, 9, 2019
  11. Unconstrained Vital Sign Monitoring System Using an Aortic Pulse Wave Sensor, SCIENTIFIC REPORTS, 9, 2019
  12. Effects of intravenous injection of indocyanine green on the oxygen reserve index (ORi (TM)), JOURNAL OF ANESTHESIA, 34(3), 338-341, 2020
  13. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245, 2020
  14. Recurrent probabilistic neural network-based short-term prediction for acute hypotension and ventricular fibrillation, SCIENTIFIC REPORTS, 10(1), 2020
  15. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70(5), 508-519, 2020
  16. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35(2), 168-174, 2021
  17. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study, SCIENTIFIC REPORTS, 11(1), 2021
  18. Cardiorespiratory synchronisation and systolic blood pressure correlation of peripheral arterial stiffness during endoscopic thoracic sympathectomy, SCIENTIFIC REPORTS, 11(1), 2021
  19. Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11(1), 2021
  20. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(5), 5119-5127, 2021
  21. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50(4), 312-319, 2022
  22. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135(1), 128-135, 2022
  23. Incidence and laryngoscopic grade of adult patients with Mallampati class zero airway, MINERVA ANESTESIOLOGICA, 82(3), 372-373, 2016
  24. Frequency Domain Analysis of Heart Rate Variability in the Early Phase of Hemorrhage: Its Relation to Development of Shock, CIRCULATION, 120(18), S1491-S1491, 2009
  25. A novel online method to monitor autonomic nervous activity based on arterial wall impedance and heart rate variability, MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 48(4), 351-359, 2010
  26. A case of coronary artery spasm caused by manipulation of the neck: heart rate variability analysis, JOURNAL OF ANESTHESIA, 26(6), 905-909, 2012
  27. Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study, PSYCHIATRY RESEARCH-NEUROIMAGING, 221(3), 246-248, 2014
  28. Asystole following skull clamp to Chiari malformation, JOURNAL OF ANESTHESIA, 29(2), 317-317, 2015
  29. Model-Based Evaluation of Reactive Hyperemia Using Strain-Gauge Plethysmography and Log-Linearized Viscoelastic Indices, JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 5(4), 334-341, 2015
  30. Factors related to accidental dural puncture in epidural anesthesia patients, JOURNAL OF CLINICAL ANESTHESIA, 27(8), 665-667, 2015
  31. Shoulder pain after hepatectomy occurs more frequently on the right side A retrospective observational analysis, EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 32(10), 744-745, 2015
  32. Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 69(12), 763-772, 2015
  33. Several Ryanodine Receptor Type 1 Gene Mutations of p.Arg2508 Are Potential Sources of Malignant Hyperthermia, ANESTHESIA AND ANALGESIA, 121(4), 994-1000, 2015
  34. A Case of Nephrogenic Diabetes Insipidus During Transsphenoidal Pituitary Adenomectomy, JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 28(1), 79-80, 2016
  35. Clinical effects of online cognitive behavioral group therapy for chronic pain patients and developing a therapeutic alliance: A pre-post pilot trial, HEALTH SCIENCE REPORTS, 7(5), 202405
    Link to Paper Search Results by DOI
  36. A Case of a Father and Son With Complex Regional Pain Syndrome Type 1 Exhibiting Different Resting-State Functional Connectivity on Functional MRI, CUREUS JOURNAL OF MEDICAL SCIENCE, 16(1), 20240119
    Link to Paper Search Results by DOI
  37. Prediction of blood pressure changes during surgical incision using the minimum evoked current of vascular stiffness value under sevoflurane anesthesia, SCIENTIFIC REPORTS, 13(1), 20231122
    Link to Paper Search Results by DOI
  38. Remimazolam-based anesthesia with flumazenil allows faster emergence than propofol-based anesthesia in older patients undergoing spinal surgery: A randomized controlled trial, MEDICINE, 102(46), 20231117
    Link to Paper Search Results by DOI
  39. Rapid cyclic fluctuations in blood pressure during two surgeries associated with pheochromocytoma: a case report, JA CLINICAL REPORTS, 8(1), 20221005
    Link to Paper Search Results by DOI
  40. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan, ANESTHESIA AND ANALGESIA, 135(1), 128-135, 202207
    Link to Paper Search Results by DOI
  41. The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia, ANAESTHESIA AND INTENSIVE CARE, 50(4), 312-319, 202207
    Link to Paper Search Results by DOI
  42. Electroencephalogram evaluation of accidental cerebral congestion during unexpected superior vena cava clamping: a case report, JA CLINICAL REPORTS, 8(1), 20220609
    Link to Paper Search Results by DOI
  43. Venous cannula occlusion during cardiopulmonary bypass recognized by ultrasonography of the internal jugular vein, JA CLINICAL REPORTS, 8(1), 20220412
    Link to Paper Search Results by DOI
  44. A novel online method to monitor autonomic nervous activity based on arterial wall impedance and heart rate variability, MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 48(4), 351-359, 201004
    Link to Paper Search Results by DOI
  45. A case of coronary artery spasm caused by manipulation of the neck: heart rate variability analysis, JOURNAL OF ANESTHESIA, 26(6), 905-909, 201212
    Link to Paper Search Results by DOI
  46. Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study, PSYCHIATRY RESEARCH-NEUROIMAGING, 221(3), 246-248, 20140330
    Link to Paper Search Results by DOI
  47. ★, Arterial Mechanical Impedance is a Sensitive Stress Response Monitor During General Anesthesia., Hiroshima J Med Sci, 58(4), 75-82, 20091201
  48. Noninvasive Estimation of Arterial Viscoelastic Indices Using a Foil-type Flexible Pressure Sensor and a Photoplethysmogram., International Journal on Electrical Engineering and Informatics, 3(4), 498-515, 20111201
  49. A Case of Protracted Anaphylaxis Caused by TachoComb Application, 32(4), 564-568, 20120701
  50. Pulse-less Electrical Activity Provoked by Bezold-Jarisch Reflex during Lumbar Puncture for Spinal Anesthesia, 32(5), 781-785, 20120901
  51. A Log-linearized Peripheral Arterial Viscoelastic Index and Its Application to Endoscopic Thoracic Sympathectomy, 20121101
  52. A Log-linearized Arterial Viscoelastic Index and Its Application to Carotid Ultrasonography, 20120901
  53. Effects of pregabalin on Japanese post-herpetic neuralgia patients, 20120401
  54. Development and evaluation of off-line pharmacokinetics simulator on cellular phone, 20120101
  55. Perioperative Vascular Tone Monitoring: Effects of Mean Arterial Pressure, 20120101
  56. Estimation of arterial viscoelastic variations using an electromagnetic induction-based carotid pulse pressure sensor., Journal of latex class files, 11, 20120401
  57. A log-linearized arterial viscoelastic model for evaluation of the carotid artery., Conf Proc IEEE Eng Med Biol Soc, 2013, 2591-2594, 20130701
  58. Monitoring of peripheral vascular condition using a log-linearized arterial viscoelastic index during endoscopic thoracic sympathectomy, Conf Proc IEEE Eng Med Biol Soc, 2013, 2587-2590, 20130701
  59. Model-Based Evaluation of Reactive Hyperemia Using Strain-Gauge Plethysmography and Log-Linearized Viscoelastic Indices, JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 5(4), 334-341, 201504
    Link to Paper Search Results by DOI
  60. Factors related to accidental dural puncture in epidural anesthesia patients, JOURNAL OF CLINICAL ANESTHESIA, 27(8), 665-667, 201512
    Link to Paper Search Results by DOI
  61. Effectiveness of group cognitive behavioral therapy for somatoform pain disorder patients in Japan: A preliminary non-case-control study, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 69(12), 763-772, 201512
    Link to Paper Search Results by DOI
  62. Several Ryanodine Receptor Type 1 Gene Mutations of p.Arg2508 Are Potential Sources of Malignant Hyperthermia, ANESTHESIA AND ANALGESIA, 121(4), 994-1000, 201510
    Link to Paper Search Results by DOI
  63. Propofol for anesthesia and postoperative sedation resulted in fewer inflammatory responses than sevoflurane anesthesia and midazolam sedation after thoracoabdominal esopagectomy., Hiroshima J Med Sci, 64(3), 31-37
  64. Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome, PEDIATRICS INTERNATIONAL, 59(1), 97-98, 201701
    Link to Paper Search Results by DOI
  65. Paravertebral block catheter breakage by electrocautery during thoracic surgery, JOURNAL OF ANESTHESIA, 31(3), 463-466, 201706
    Link to Paper Search Results by DOI
  66. Alteration of Arterial Mechanical Impedance Greater than that of Photoplethysmogram and Laser Doppler Flowmetry during Endoscopic Thoracic Sympathectomy, JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 37(6), 820-825, 201712
    Link to Paper Search Results by DOI
  67. Quantitative Evaluation of Pain during Electrocutaneous Stimulation using a Log-Linearized Peripheral Arterial Viscoelastic Model, SCIENTIFIC REPORTS, 8, 20180215
    Link to Paper Search Results by DOI
  68. ★, A new arterial mechanical property indicator reflecting differences in invasive stimulus intensity induced by alteration of remifentanil concentration during laryngoscopy, MINERVA ANESTESIOLOGICA, 84(3), 311-318, 201803
    Link to Paper Search Results by DOI
  69. Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation, SCIENTIFIC REPORTS, 8, 20180618
    Link to Paper Search Results by DOI
  70. Postoperative thoracic and low back pain following endovascular aortic repair associated with stenting location, JOURNAL OF ANESTHESIA, 33(1), 75-79, 201902
    Link to Paper Search Results by DOI
  71. Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function, SCIENTIFIC REPORTS, 9, 20190222
    Link to Paper Search Results by DOI
  72. Unconstrained Vital Sign Monitoring System Using an Aortic Pulse Wave Sensor, SCIENTIFIC REPORTS, 9, 20191125
    Link to Paper Search Results by DOI
  73. Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury, LIFE SCIENCES, 245, 20200315
    Link to Paper Search Results by DOI
  74. Effects of intravenous injection of indocyanine green on the oxygen reserve index (ORi (TM)), JOURNAL OF ANESTHESIA, 34(3), 338-341, 20200620
    Link to Paper Search Results by DOI
  75. Recurrent probabilistic neural network-based short-term prediction for acute hypotension and ventricular fibrillation, SCIENTIFIC REPORTS, 10(1), 20200720
    Link to Paper Search Results by DOI
  76. Validity of Japanese Version of Neuropathic Pain Screening Questionnaire for Cancer Pain with Neuropathic Pain, Palliative Care Research, 15(1), 15-20
  77. A Case of Horner's Syndrome Caused by Thoracic Epidural Anesthesia, 55(1), 49-51
  78. Safe transfer to operating table: step stool and operating table heights, 38(2), 111-117
  79. Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis, REVISTA BRASILEIRA DE ANESTESIOLOGIA, 70(5), 508-519, 2020
    Link to Paper Search Results by DOI
  80. Novel technique for identification of the pulmonary intersegmental plane using manual jet ventilation during pulmonary segmentectomy, VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES, 16(1), 169-174, 20210316
    Link to Paper Search Results by DOI
  81. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats, JOURNAL OF ANESTHESIA, 35(2), 168-174, 202104
    Link to Paper Search Results by DOI
  82. Cardiorespiratory synchronisation and systolic blood pressure correlation of peripheral arterial stiffness during endoscopic thoracic sympathectomy, SCIENTIFIC REPORTS, 11(1), 20210316
    Link to Paper Search Results by DOI
  83. Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study, SCIENTIFIC REPORTS, 11(1), 20210224
    Link to Paper Search Results by DOI
  84. ★, Prediction of blood pressure change during surgical incision under opioid analgesia using sympathetic response evoking threshold, SCIENTIFIC REPORTS, 11(1), 20210505
    Link to Paper Search Results by DOI
  85. Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(5), 5119-5127, 202105
    Link to Paper Search Results by DOI
  86. Relationship Between the Loaded Pressure and Flow Rate of Packed Red Blood Cells and Various Infusion Solutions in Normal Infusion Lines and Catheters, ANESTHESIA AND ANALGESIA, 133(5), 1107-1115, 202111
    Link to Paper Search Results by DOI
  87. Paradoxical increase in the photoplethysmography amplitude in response to nociceptive stimulation induced by tracheal intubation : A case report, JOURNAL OF MEDICAL INVESTIGATION, 68(3-4), 383-385, 202108
  88. Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study, ANNALS OF PALLIATIVE MEDICINE, 10(10), 10160-10169, 202110
    Link to Paper Search Results by DOI