MASASHI FUJII
Last Updated :2025/04/03
- Affiliations, Positions
- Graduate School of Integrated Sciences for Life, Assistant Professor
- Web Site
- E-mail
- m-fujii0123
hiroshima-u.ac.jp
- Self-introduction
- I specialize in multi-scale simulation from atoms and molecules to cells and tissues and statistical analysis. I build models for phenomena that are difficult to observe directly due to temporal, spatial, and experimental constraints, leading to new discoveries!
Basic Information
Major Professional Backgrounds
- 2010/04/01, 2013/03/31, JSPS, Research fellow (DC1)
- 2013/04/01, 2014/03/31, University of Tokyo, Department of Biophysics and Biochemistry, Graduate School of Science, Research fellow
- 2014/04/01, 2016/11/30, University of Tokyo, Department of Biological Sciences, Graduate School of Science, Project Research Associate
- 2016/12/01, 2019/03/31, University of Tokyo, Molecular Genetics Research Laboratory, Graduate School of Science, Research Associate
- 2019/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Research Associate
Educational Backgrounds
- Hiroshima University, Graduate School of Science, Department of Mathematical and Life Sciences, Japan, 2010/04/01, 2013/03/23
- Hiroshima University, Graduate School of Science, Department of Mathematical and Life Sciences, Japan, 2008/04/01, 2010/03/23
- Hiroshima University, Faculty of Science, Japan, 2004/04, 2008/03
Academic Degrees
- Hiroshima University
- Hiroshima University
Educational Activity
- [Bachelor Degree Program] School of Science : Mathematics : Mathematics
- [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Mathematical and Life Sciences
- [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Mathematical and Life Sciences
In Charge of Primary Major Programs
Research Fields
- Mathematical and physical sciences;Physics;Biological physics / Chemical physics / Soft matter physics
- Biological Sciences;Genome science;System genome science
- Informatics;Human informatics;Kansei informatics
- Biology;Biological Science;Biophysics
Research Keywords
- Theoretical Biophysics
- Systems Biology
Affiliated Academic Societies
- Japan Physical Society, 2008/07
- Biophysical Society of Japan, 2011/06
Educational Activity
Course in Charge
- 2025, Undergraduate Education, 3Term, Introduction to Information Mathematics
- 2025, Undergraduate Education, 2Term, Exercises in Mathematical Software
- 2025, Undergraduate Education, 4Term, Exercises in Mathematics for Computation
- 2025, Undergraduate Education, 1Term, Exercises in Mathematics for Computation A
- 2025, Undergraduate Education, First Semester, Special Study of Mathematics and Informatics for Graduation
- 2025, Undergraduate Education, Second Semester, Special Study of Mathematics and Informatics for Graduation
- 2025, Graduate Education (Master's Program) , 3Term, Research Methods in Life Science
- 2025, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Mathematical and Life Sciences
- 2025, Graduate Education (Master's Program) , 1Term, Computational Mathematics A
- 2025, Graduate Education (Master's Program) , 4Term, Computational Mathematics B
- 2025, Graduate Education (Master's Program) , 2Term, Topical Seminar in Mathematical Science A
- 2025, Graduate Education (Master's Program) , 4Term, Topical Seminar in Mathematical Science B
- 2025, Graduate Education (Master's Program) , First Semester, Exercises in Applied Mathematics and Computational Science A
- 2025, Graduate Education (Master's Program) , Second Semester, Exercises in Applied Mathematics and Computational Science B
Research Activities
Academic Papers
- Characteristic growth of chemical gardens from mixtures of two salts, Physical Chemistry Chemical Physics, 25(18), 12974-12978, 20230510
- Identification of aberrant transcription termination at specific gene loci with DNA hypomethylated transcription termination sites caused by DNA methyltransferase deficiency, Genes & Genetic Systems, 97(3), 139-152, 202206
- Methylome data derived from maternal-zygotic DNA methyltransferase 3aa(-/-) zebrafish, Data in Brief, 44, 202210
- In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states, Scientific Reports, 12(1), 2022
- Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells, Biophysics and Physicobiology, 19, 2022
- Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole., Genes to cells : devoted to molecular & cellular mechanisms, 27(6), 1-17, 2022
- Mathematical model of chromosomal dynamics during DNA double strand break repair in budding yeast, Biophysics and Physicobiology, 19, 2022
- Self-Organization of Diverse Directional Hierarchical Networks in Simple Coupled Maps with Connection Changes, Journal of The Physical Society of Japan, 91(2), 20220215
- Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans, npj Systems Biology and Applications, 8(1), 20220208
- Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis., Cancer research, 81(8), 1988-2001, 2021
- Trans-omic Analysis Reveals ROS-Dependent Pentose Phosphate Pathway Activation after High-Frequency Electrical Stimulation in C2C12 Myotubes, iScience, 23(10), 101558, 20201023
- Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle., iScience, 24(3), 2021
- Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity, Science Signaling, 13(660), 20201201
- Spontaneous Organizations of Diverse Network Structures in Coupled Logistic Maps with a Delayed Connection Change, Journal of The Physical Society of Japan, 89(11), 20201115
- Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics, Quantitative Biology, 8(3), 228-237, 202009
- Single-Cell Information Analysis Reveals That Skeletal Muscles Incorporate Cell-to-Cell Variability as Information Not Noise, Cell Reports, 32(9), 20200901
- Affinity of rhodopsin to raft enables the aligned oligomer formation from dimers: Coarse-grained molecular dynamics simulation of disk membranes., PloS one, 15(2), 2020
- Ultrasensitive Change in Nucleosome Binding by Multiple Phosphorylations to the Intrinsically Disordered Region of the Histone Chaperone FACT, Journal of Molecular Biology, 432(16), 4637-4657, 20200724
- Robustness against additional noise in cellular information transmission., Physical review. E, 100(4-1), 042403, 2019
- Logical design of oral glucose ingestion pattern minimizing blood glucose in humans., npj Systems Biology and Applications, 5, 31, 2019
- NMDAR-Mediated Ca2+ Increase Shows Robust Information Transfer in Dendritic Spines., Biophysical journal, 116(9), 1748-1758, 2019
- Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects., NPJ systems biology and applications, 4(1), 14, 2018
- Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data., Genes to cells : devoted to molecular & cellular mechanisms, 24(1), 82-93, 2019
- Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks., iScience, 7, 212-229, 2018
- System identification of signaling dependent gene expression with different time-scale data., PLoS computational biology, 13(12), e1005913, 2017
- Small-Volume Effect Enables Robust, Sensitive, and Efficient Information Transfer in the Spine, Biophysical Journal, 112(4), 813-826, 2017
- Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin., Science signaling, 9(455), ra112, 2016
- Laguerre Filter Analysis with Partial Least Square Regression Reveals a Priming Effect of ERK and CREB on c-FOS Induction., PloS one, 11(8), e0160548, 2016
- Glucose Homeostatic Law: Insulin Clearance Predicts the Progression of Glucose Intolerance in Humans., PloS one, 10(12), e0143880, 2015
- Stochasticity in Ca2+ increase in spines enables robust and sensitive information coding., PloS one, 9(6), e99040, 2014
- Influences of Excluded Volume of Molecules on Signaling Processes on the Biomembrane, PLoS ONE, 8(5), e62218, 2013
- Segregation-pattern reorientation of a granular mixture on a horizontally oscillating tray, Physical Review E, 85(4), 041304, 2012
- Saddle-node bifurcation to jammed state for quasi-one-dimensional counter-chemotactic flow, Physical Review E, 82(2), 015102, 2010
- Counter Chemotactic Flow in Quasi-One-Dimensional Path, Journal of the Physical Society of Japan, 78(7), 073801, 2009
External Funds
Acceptance Results of Competitive Funds
- KAKENHI, Construction of a Framework for Large-Scale Coarse-Grained Molecular Dynamics Simulation, 2024/04/01, 2029/03/31
- KAKENHI, 2019/04/01, 2023/03/31
- KAKENHI, 2016/04/04, 2019/03/31
- KAKENHI, 2010/04/01, 2013/03/31