AKIO TANAKA

Last Updated :2026/01/07

Affiliations, Positions
Graduate School of Biomedical and Health Sciences, Professor
Self-introduction
I am a dermatologist. My research fields are atopic dermatitis, urticaria, and skin perception.

Basic Information

Major Professional Backgrounds

  • 2017/04/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Dermatology

Research Keywords

  • Atopic dermatitis
  • Urticaria
  • Pruritus and skin perception

Affiliated Academic Societies

  • Reseach Society for the Treatment of Atopic Dermatitis

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2025, Undergraduate Education, Intensive, Practice for medical research
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2025, Undergraduate Education, 2Term, Dermatology
  6. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dermatology
  7. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dermatology
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dermatology
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dermatology

Research Activities

Academic Papers

  1. Survey of hereditary angioedema episodes and quality of life impairment through a patient-participatory registry, Journal of Cutaneous Immunology and Allergy, 7, 12626-12626, 2024
  2. A Case of Graham–Little–Piccardi–Lasseur Syndrome Successfully Treated with Minocycline, Acta Dermato-Venereologica, 104, adv40008-adv40008, 2024
  3. Improved atopic dermatitis accompanied by pompholyx, Journal of Cutaneous Immunology and Allergy, 7, 13559-13559, 2024
  4. A Staphylococcus epidermidis strain inhibits the uptake of Staphylococcus aureus derived from atopic dermatitis skin into the keratinocytes, Journal of Dermatological Science, 113(3), 113-120, 2024
  5. Biomarkers and patient related factors associated with clinical outcomes in dupilumab treated atopic dermatitis, Journal of Allergy and Clinical Immunology: Global, 3(4), 100317-100317, 2024
  6. Patients and caregivers perspectives of the atopic dermatitis journey, Journal of Dermatological Treatment, 35(1), 2315145-2315145, 2024
  7. Physicians perspectives and practice in atopic dermatitis management: a cross-sectional online survey in Japan, Journal of Cutaneous Immunology and Allergy, 7, 12567-12567, 2024
  8. Lebrikizumab Combined with Topical Corticosteroids Improves Patient-reported Outcomes in Japanese Patients with Moderate-to-severe Atopic Dermatitis, Acta Dermato-Venereologica, 104, adv34375-adv34375, 2024
  9. The ability of biomarkers to assess the severity of atopic dermatitis, Journal of Allergy and Clinical Immunology: Global, 3(1), 100175-100175, 2024
  10. A case of atopic dermatitis with self-healing acute diffuse and total alopecia during nemolizumab treatment, Journal of Dermatology, 51(4), e123-e124, 2024
  11. Exploring patient background and biomarkers associated with the development of dupilumab-associated conjunctivitis and blepharitis, Allergology International, 73(2), 332-334, 2024
  12. Cost-effectiveness analysis of abrocitinib compared with standard of care in adult moderate-to-severe atopic dermatitis in Japan, Journal of Dermatology, 51(6), 759-771, 2024
  13. Low-intensity pulsed ultrasound for 'no-option' chronic/critical limb-threatening ischaemia in a patient with Buerger disease: a case report, European Heart Journal - Case Reports, 8(6), ytae246-ytae246, 2024
  14. Efficacy and safety of nemolizumab and topical corticosteroids for prurigo nodularis: results from a randomized double-blind placebo-controlled phase II/III clinical study in patients aged ≥ 13 years, British Journal of Dermatology, 191(2), 200-208, 2024
  15. Efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: A randomized, double-blind, placebo-controlled phase 3 study, Allergology International, 73(4), 532-542, 2024
  16. Patient and family burden in pediatric atopic dermatitis and its treatment pattern in Japan, International Journal of Dermatology, 63(11), e322-e334, 2024
  17. A Case of Idiopathic Follicular Mucinosis Treated Successfully with Cyclosporine, Acta Dermatovenerologica Croatica, 32(4), 210-211, 2024
  18. A case of atopic dermatitis with self-healing acute diffuse and total alopecia during nemolizumab treatment, J Dermatol, 6(November), 202311
  19. Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching, Frontiers in Immunology, 14, 1251031-1251031, 202311
  20. Efficacy of baricitinib 4 mg in patients with moderate-to-severe atopic dermatitis previously treated with systemic therapy, JEADV Clinical Practice, 2(3), 583-589, 202309
  21. Time Course of Priming Effect of TF Inducers on Synergistic TF Expression and Intra-Cellular Gap Formation of Human Vascular Endothelial Cells via the Extrinsic Coagulation Cascade, International Journal of Molecular Sciences, 24(15), 12388-12388, 202308
  22. Changes in patient-perceived aggravating factors during the course of atopic dermatitis, Journal of Cutaneous Immunology and Allergy, 6(6), 219-224, 202312
  23. Atypical form of transient acantholytic dermatosis with edematous erythema, Dermatology Reports, 15(4), 9701-9701, 202305
  24. Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study), Clinical and Experimental Allergy, 53(2), 233-238, 202302
  25. Axillary web syndrome with vascular thrombosis and arterial intimal hyperplasia, JAAD Case Reports, 34, 32-35, 202304
  26. The expression of prolyl isomerase Pin1 is expanded in the skin of patients with atopic dermatitis and facilitates IL-33 expression in HaCaT cells, Journal of Dermatology, 50(4), 462-471, 202304
  27. Oncostatin M's Involvement in the Pathogenesis of Chronic Rhinosinusitis:Focus on Type 1 and 2 Inflammation, Biomedicines, 11(12), 3224-3224, 202312
  28. Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems, International Journal of Molecular Sciences, 24(12), 10320-10320, 202301
  29. Enhancing evidence-informed policymaking in medicine and healthcare: stakeholder involvement in the Commons Project for rare diseases in Japan, Research Involvement and Engagement, 9(1), 107-107, 202312
  30. Semi-purification of the IgE-sweat antigen acting on mast cells and basophils in atopic dermatitis., Exp. Dermatol., 15, 283-290, 20060101
  31. Pelodera strongyloides infection presenting as pruritic dermatitis., J Am Acad Dermatol, 51, S181-184, 20040401
  32. A large heterozygous deletion including the entire C1 inhibitor gene in a sporadic case of hereditary angio-oedema, CLINICAL AND EXPERIMENTAL DERMATOLOGY, 37(1), 20-23, 201201
    Link to Paper Search Results by DOI
  33. ★, Germ line Mutation in ATR in Autosomal-Dominant Oropharyngeal Cancer Syndrome, AMERICAN JOURNAL OF HUMAN GENETICS, 90(3), 511-517, 2012
    Link to Paper Search Results by DOI
  34. Elevated Serum IgE against MGL_1304 in Patients with Atopic Dermatitis and Cholinergic Urticaria, ALLERGOLOGY INTERNATIONAL, 63(1), 83-93, 201403
    Link to Paper Search Results by DOI
  35. Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy, ALLERGOLOGY INTERNATIONAL, 64(3), 266-271, 201507
    Link to Paper Search Results by DOI
  36. A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 468(1-2), 99-104, 2015
    Link to Paper Search Results by DOI
  37. ★, Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016, JOURNAL OF DERMATOLOGY, 43(10), 1117-1145, 201610
    Link to Paper Search Results by DOI
  38. Oral administration of -carotene or lycopene prevents atopic dermatitis-like dermatitis in HR-1 mice, JOURNAL OF DERMATOLOGY, 43(10), 1188-1192, 201610
    Link to Paper Search Results by DOI
  39. Novel truncating mutations in PKP1 and DSP cause similar skin phenotypes in two Brazilian families., Br J Dermatol, 160(3), 692-697, 200903
  40. Kindler syndrome: a focal adhesion genodermatosis., Br J Dermatol, 160(2), 233-242, 200902
  41. ★, New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis., Br J Dermatol, 161(6), 1217-1224, 200912
  42. New glycine substitution mutations in type VII collagen underlying epidermolysis bullosa pruriginosa but the phenotype is not explained by a common polymorphism in the matrix metalloproteinase-1 gene promoter., Acta Derm Venereol,, 89(1), 6-11, 2009
  43. ★, Recurrent European missense mutation in the F12 gene in a British family with type III hereditary angioedema., J Dermatol Sci, 56(1), 62-64, 200910
  44. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis., Eur J Hum Genet, 18(1), 26-32, 201001
  45. Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation., Am J Pathol, 175(4), 1431-1441, 200910
  46. Revertant mosaicism in recessive dystrophic epidermolysis bullosa., J Invest Dermatol, 130(7), 1937-1940, 201007
  47. Identification of a homozygous deletion mutation in C16orf57 in a family with Clericuzio-type poikiloderma with neutropenia., Am J Med Genet A, 152A(6), 1347-1348, 201006
  48. The molecular skin pathology of familial primary localized cutaneous amyloidosis., Exp Dermatol, 19(5), 416-423, 201005
  49. Common IL-31 gene haplotype associated with non-atopic eczema is not implicated in epidermolysis bullosa pruriginosa., Acta Derm Venereol, 90(6), 631-632, 201011
  50. HB-EGF induces COL7A1 expression in keratinocytes and fibroblasts: possible mechanism underlying allogeneic fibroblast therapy in recessive dystrophic epidermolysis Bullosa., J Invest Dermatol, 131(8), 1771-1774, 201108
  51. Novel and recurrent C1 inhibitor gene mutations in nine Japanese patients with hereditary angioedema., J Dermatol Sci, 68(1), 68-70, 201210
  52. Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair., J Dermatol, 43(11), 1384-1385, 201611
  53. ★, ATR gene mutations in HPV negative oropharyngeal cancer., Oral Oncol, 65, 121-123, 201702
  54. Contact urticaria syndrome with IgE antibody against a cefotiam-unique structure, evoked by nonapparent exposure to cefotiam, CLINICAL AND EXPERIMENTAL DERMATOLOGY, 42(5), 527-531, 201707
    Link to Paper Search Results by DOI
  55. Pityriasis lichenoides et varioliformis acuta after vaccination, J Cutan Immunol Allergy, 1(1), 37-38, 201802
  56. Prognosis of adult-onset clinically amyopathic dermatomyositis treated with only topical therapy., J Dermatol., 44(7), e178-e179, 201707
  57. Sweat allergy, ALLERGOLOGY INTERNATIONAL, 67(4), 435-441, 201810
    Link to Paper Search Results by DOI
  58. Activation of Human Peripheral Basophils in Response to High IgE Antibody Concentrations without Antigens, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1), 20190101
    Link to Paper Search Results by DOI
  59. Presymptomatic genetic diagnosis of two siblings with hereditary angioedema, presenting with unusual normal levels of serum C4., J Dermatol., 45(2), e31-e32, 201802
  60. A unique clinical phenotype of a patient bearing a newly identified deletion mutation in the PSENEN gene along with the pathogenic serum desmoglein-1 antibody., Clin Exp Dermatol., 43(3), 329-332, 201804
  61. A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient., Clin Exp Dermatol., 43(5), 636-638, 201807
  62. Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2., Allergy, 73(11), 2256-2260, 201811
  63. Clinical practice guidelines for the management of atopic dermatitis 2018, JOURNAL OF DERMATOLOGY, 46(12), 1053-1101, 201912
    Link to Paper Search Results by DOI
  64. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe, ALLERGOLOGY INTERNATIONAL, 69(2), 253-260, 202004
    Link to Paper Search Results by DOI
  65. Randomized double-blind cross-over trial of bath additive containing tannic acid in patients with atopic dermatitis, JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY, 3(3), 56-61, 202006
    Link to Paper Search Results by DOI
  66. Rechallenge of programmed cell death 1 inhibitor after an interval with dacarbazine treatment may be effective for advanced malignant melanoma, JOURNAL OF DERMATOLOGY, 47(8), 907-910, 202008
    Link to Paper Search Results by DOI
  67. A case of millet allergy that developed into wheat-induced anaphylaxis by cross-reaction between millet and wheat antigens, Allergology International, 69(3), 471-473, 202008
  68. High histamine concentrations in human sweat in association with type I allergy to the semi-purified sweat antigen, Allergology International, 69(2), 307-309, 202004
  69. Three cases of advanced cutaneous squamous cell carcinoma treated with a combination of carboplatin and epirubicin, European Journal of Hospital Pharmacy, 27(2), 128-128, 202003
  70. ★, Reduction of serum thymus and activation-regulated chemokine after short-term intensive therapy may predict better prognosis of moderate to severe atopic dermatitis, 46(12), e486-e487, 201912
  71. Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab A study protocol, MEDICINE, 99(38), 20200918
    Link to Paper Search Results by DOI
  72. Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1 beta, JOURNAL OF DERMATOLOGY, 47(11), 1293-1300, 202011
    Link to Paper Search Results by DOI
  73. Calculation of practical skin donor area for meshed skin grafting in real-world surgery, DERMATOLOGIC THERAPY, 33(6), 202011
    Link to Paper Search Results by DOI
  74. Analysis of the long-term economic burden of omalizumab on patients with chronic spontaneous urticaria, JOURNAL OF DERMATOLOGY, 48(1), 56-63, 202101
    Link to Paper Search Results by DOI
  75. Japanese guidelines for atopic dermatitis 2020, ALLERGOLOGY INTERNATIONAL, 69(3), 356-369, 202007
    Link to Paper Search Results by DOI
  76. Survey of actual conditions of erythema marginatum as a prodromal symptom in Japanese patients with hereditary angioedema, WORLD ALLERGY ORGANIZATION JOURNAL, 14(2), 202102
    Link to Paper Search Results by DOI
  77. Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria, ALLERGY, 75(4), 971-974, 202004
    Link to Paper Search Results by DOI
  78. ★, The relationship between the development of erythroderma in patients with atopic dermatitis and the avoidance of anti-inflammatory topical drugs., Allergol Int, 70(3), 376-378, 202107
  79. Iatrogenic cutaneous lymphoid hyperplasia induced by squaric acid dibutyl ester., Contact Dermatitis, 85(1), 88-90, 202107
  80. ★, Time course of disease severity from birth to 19 years old in patients with moderate to severe atopic dermatitis in adulthood., J Dermatol, 48(5), e205-e206, 202105

Invited Lecture, Oral Presentation, Poster Presentation

  1. A web-based epidemiological study of the clinical course of atopic dermatitis in Japan., Akio Tanaka, Satoshi Morioke,Michihiro Hide, Yukihiro Ohya, Naoki Shimojyo, Akira Akazawa., The 44th Annual Meeting of the Japanese Society for Investigative Dermatology, 2019/11, Without Invitation, English, the Japanese Society for Investigative Dermatology, Aomori, Japan
  2. Atopic Dermatitis in France and Japan From Treatment Guidelines to Patient Benefit, Akio Tanaka, France-Japan Joint Workshop for Skin Care in Bordeaux 2019, 2019/09/21, Without Invitation, English, NAOS, Bordeaux, France
  3. Impaired CCL2 expression caused by the OSMR gene mutations in familial primary localized cutaneous amyloidosis, Akio Tanaka, Ryo Saito, Kazue Uchida, Tomoko Kawaguchi, John McGrath, Michihiro Hide, 49th Annual ESDR Meeting, 2019/09, Without Invitation, English, The European Society for Dermatological Research, Bordeaux, France
  4. Japanese Guidelines for Atopic Dermatitis (AD) and clinical experiences with a new drug for AD, Dupilumab, Akio Tanaka, Korean Dermatological Association The 70th Spring Meeting, 2018/04, With Invitation, English
  5. Angioedema in Japan, Akio Tanaka, Korean Academy of Asthma, Allergy and Clinical Immunology, 2017/11/05, With Invitation, English, Korean Academy of Asthma, Allergy and Clinical Immunology, Muju
  6. Hereditary Angioedema - Disease State & Treatment, Akio Tanaka, HAE symposium 2017, 2017/11/03, With Invitation, English, HAE symposium 2017, Seoul
  7. HAE in Japan, Tanaka Akio, Joint Congress of APAAACI & APAPARI 2016., 2016/10/17, With Invitation, English, Kuala Lumpur, Malaysia
  8. Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair., Tanaka A, Matsuo Y, Shimomura Y, Hide M., 46th Annual ESDR Meeting, 2016/09/07, Without Invitation, English, European Society for Dermatological Research, Munich, Germany
  9. Development of a questionnaire for secular change of atopic dermatitis from birth to 19- year-old., Akio Tanaka, Satoshi Morioke, Hiroko Shizukawa, Michihiro Hide, Yukihiro Ohya, Naoki Shimojyo, Akira Akazawa., XXIV World Allergy Congress, 2015/10/14, Without Invitation, English, The World Allergy Organization, Seoul, Korea
  10. A web-based epidemiological study of the clinical course of atopic dermatitis in Japan., Akio Tanaka, Satoshi Morioke, Hiroko Shizukawa, Michihiro Hide, Yukihiro Ohya, Naoki Shimojyo, Akira Akazawa., 2015/05/26, Without Invitation, English
  11. HAE in Japan., Tanaka Akio, 2013 Asia Pacific Congress of Allergy, Asthma, and Clinical Immunology., 2013, With Invitation, English, Taipei, Taiwan
  12. Pruritus and Amyloidosis., Tanaka Akio, 6th World Congress on Itch 2011, 2011, With Invitation, English, Brest, France

Awards

  1. 2012/05/12, SID/JSID Young Fellow Collegiality Awards, The Japanese Society for Investigative Dermatology

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2016
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  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021

Social Activities

History as Committee Members

  1. Councilor, 2015/06/19, 2018/06, The Japanese Society for Investigative Dermatology