AKIO TANAKA

Last Updated :2025/04/03

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medical), Professor
Self-introduction
I am a dermatologist. My research fields are atopic dermatitis, urticaria, and skin perception.

Basic Information

Major Professional Backgrounds

  • 2017/04/01, 2019/03/31, Hiroshima University, Graduate School of Biomedical & Health Sciences, Associate Professor

Academic Degrees

  • Doctor of Philosophy in Medical Science, Hiroshima University

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Dermatology

Research Keywords

  • Atopic dermatitis
  • Urticaria
  • Pruritus and skin perception

Affiliated Academic Societies

  • Reseach Society for the Treatment of Atopic Dermatitis

Educational Activity

Course in Charge

  1. 2025, Undergraduate Education, Year, Clinical diagnosis and treatment II
  2. 2025, Undergraduate Education, Intensive, Practice for medical research
  3. 2025, Undergraduate Education, Intensive, Practice of Medicine I
  4. 2025, Undergraduate Education, Intensive, Practice of Medicine II
  5. 2025, Undergraduate Education, 2Term, Dermatology
  6. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Dermatology
  7. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Dermatology
  8. 2025, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Dermatology
  9. 2025, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Dermatology

Research Activities

Academic Papers

  1. A case of atopic dermatitis with self-healing acute diffuse and total alopecia during nemolizumab treatment, J Dermatol, 6(November), 202311
  2. Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching, Frontiers in Immunology, 14, 1251031-1251031, 202311
  3. Efficacy of baricitinib 4 mg in patients with moderate-to-severe atopic dermatitis previously treated with systemic therapy, JEADV Clinical Practice, 2(3), 583-589, 202309
  4. Time Course of Priming Effect of TF Inducers on Synergistic TF Expression and Intra-Cellular Gap Formation of Human Vascular Endothelial Cells via the Extrinsic Coagulation Cascade, International Journal of Molecular Sciences, 24(15), 12388-12388, 202308
  5. Changes in patient-perceived aggravating factors during the course of atopic dermatitis, Journal of Cutaneous Immunology and Allergy, 6(6), 219-224, 202312
  6. Atypical form of transient acantholytic dermatosis with edematous erythema, Dermatology Reports, 15(4), 9701-9701, 202305
  7. Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study), Clinical and Experimental Allergy, 53(2), 233-238, 202302
  8. Axillary web syndrome with vascular thrombosis and arterial intimal hyperplasia, JAAD Case Reports, 34, 32-35, 202304
  9. The expression of prolyl isomerase Pin1 is expanded in the skin of patients with atopic dermatitis and facilitates IL-33 expression in HaCaT cells, Journal of Dermatology, 50(4), 462-471, 202304
  10. Oncostatin M's Involvement in the Pathogenesis of Chronic Rhinosinusitis:Focus on Type 1 and 2 Inflammation, Biomedicines, 11(12), 3224-3224, 202312
  11. Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems, International Journal of Molecular Sciences, 24(12), 10320-10320, 202301
  12. Enhancing evidence-informed policymaking in medicine and healthcare: stakeholder involvement in the Commons Project for rare diseases in Japan, Research Involvement and Engagement, 9(1), 107-107, 202312
  13. Semi-purification of the IgE-sweat antigen acting on mast cells and basophils in atopic dermatitis., Exp. Dermatol., 15, 283-290, 20060101
  14. Pelodera strongyloides infection presenting as pruritic dermatitis., J Am Acad Dermatol, 51, S181-184, 20040401
  15. A large heterozygous deletion including the entire C1 inhibitor gene in a sporadic case of hereditary angio-oedema, CLINICAL AND EXPERIMENTAL DERMATOLOGY, 37(1), 20-23, 201201
    Link to Paper Search Results by DOI
  16. ★, Germ line Mutation in ATR in Autosomal-Dominant Oropharyngeal Cancer Syndrome, AMERICAN JOURNAL OF HUMAN GENETICS, 90(3), 511-517, 2012
    Link to Paper Search Results by DOI
  17. Elevated Serum IgE against MGL_1304 in Patients with Atopic Dermatitis and Cholinergic Urticaria, ALLERGOLOGY INTERNATIONAL, 63(1), 83-93, 201403
    Link to Paper Search Results by DOI
  18. Evaluation of recombinant MGL_1304 produced by Pichia pastoris for clinical application to sweat allergy, ALLERGOLOGY INTERNATIONAL, 64(3), 266-271, 201507
    Link to Paper Search Results by DOI
  19. A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 468(1-2), 99-104, 2015
    Link to Paper Search Results by DOI
  20. ★, Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016, JOURNAL OF DERMATOLOGY, 43(10), 1117-1145, 201610
    Link to Paper Search Results by DOI
  21. Oral administration of -carotene or lycopene prevents atopic dermatitis-like dermatitis in HR-1 mice, JOURNAL OF DERMATOLOGY, 43(10), 1188-1192, 201610
    Link to Paper Search Results by DOI
  22. Novel truncating mutations in PKP1 and DSP cause similar skin phenotypes in two Brazilian families., Br J Dermatol, 160(3), 692-697, 200903
  23. Kindler syndrome: a focal adhesion genodermatosis., Br J Dermatol, 160(2), 233-242, 200902
  24. ★, New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis., Br J Dermatol, 161(6), 1217-1224, 200912
  25. New glycine substitution mutations in type VII collagen underlying epidermolysis bullosa pruriginosa but the phenotype is not explained by a common polymorphism in the matrix metalloproteinase-1 gene promoter., Acta Derm Venereol,, 89(1), 6-11, 2009
  26. ★, Recurrent European missense mutation in the F12 gene in a British family with type III hereditary angioedema., J Dermatol Sci, 56(1), 62-64, 200910
  27. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis., Eur J Hum Genet, 18(1), 26-32, 201001
  28. Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation., Am J Pathol, 175(4), 1431-1441, 200910
  29. Revertant mosaicism in recessive dystrophic epidermolysis bullosa., J Invest Dermatol, 130(7), 1937-1940, 201007
  30. Identification of a homozygous deletion mutation in C16orf57 in a family with Clericuzio-type poikiloderma with neutropenia., Am J Med Genet A, 152A(6), 1347-1348, 201006
  31. The molecular skin pathology of familial primary localized cutaneous amyloidosis., Exp Dermatol, 19(5), 416-423, 201005
  32. Common IL-31 gene haplotype associated with non-atopic eczema is not implicated in epidermolysis bullosa pruriginosa., Acta Derm Venereol, 90(6), 631-632, 201011
  33. HB-EGF induces COL7A1 expression in keratinocytes and fibroblasts: possible mechanism underlying allogeneic fibroblast therapy in recessive dystrophic epidermolysis Bullosa., J Invest Dermatol, 131(8), 1771-1774, 201108
  34. Novel and recurrent C1 inhibitor gene mutations in nine Japanese patients with hereditary angioedema., J Dermatol Sci, 68(1), 68-70, 201210
  35. Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair., J Dermatol, 43(11), 1384-1385, 201611
  36. ★, ATR gene mutations in HPV negative oropharyngeal cancer., Oral Oncol, 65, 121-123, 201702
  37. Contact urticaria syndrome with IgE antibody against a cefotiam-unique structure, evoked by nonapparent exposure to cefotiam, CLINICAL AND EXPERIMENTAL DERMATOLOGY, 42(5), 527-531, 201707
    Link to Paper Search Results by DOI
  38. Pityriasis lichenoides et varioliformis acuta after vaccination, J Cutan Immunol Allergy, 1(1), 37-38, 201802
  39. Prognosis of adult-onset clinically amyopathic dermatomyositis treated with only topical therapy., J Dermatol., 44(7), e178-e179, 201707
  40. Sweat allergy, ALLERGOLOGY INTERNATIONAL, 67(4), 435-441, 201810
    Link to Paper Search Results by DOI
  41. Activation of Human Peripheral Basophils in Response to High IgE Antibody Concentrations without Antigens, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1), 20190101
    Link to Paper Search Results by DOI
  42. Presymptomatic genetic diagnosis of two siblings with hereditary angioedema, presenting with unusual normal levels of serum C4., J Dermatol., 45(2), e31-e32, 201802
  43. A unique clinical phenotype of a patient bearing a newly identified deletion mutation in the PSENEN gene along with the pathogenic serum desmoglein-1 antibody., Clin Exp Dermatol., 43(3), 329-332, 201804
  44. A case of Kaposi varicelliform eruption progressing to herpes simplex virus hepatitis in an immunocompetent patient., Clin Exp Dermatol., 43(5), 636-638, 201807
  45. Neuromedin U directly induces degranulation of skin mast cells, presumably via MRGPRX2., Allergy, 73(11), 2256-2260, 201811
  46. Clinical practice guidelines for the management of atopic dermatitis 2018, JOURNAL OF DERMATOLOGY, 46(12), 1053-1101, 201912
    Link to Paper Search Results by DOI
  47. Type-I-hypersensitivity to 15 kDa, 28 kDa and 54 kDa proteins in vitellogenin specific to Gadus chalcogrammus roe, ALLERGOLOGY INTERNATIONAL, 69(2), 253-260, 202004
    Link to Paper Search Results by DOI
  48. Randomized double-blind cross-over trial of bath additive containing tannic acid in patients with atopic dermatitis, JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY, 3(3), 56-61, 202006
    Link to Paper Search Results by DOI
  49. Rechallenge of programmed cell death 1 inhibitor after an interval with dacarbazine treatment may be effective for advanced malignant melanoma, JOURNAL OF DERMATOLOGY, 47(8), 907-910, 202008
    Link to Paper Search Results by DOI
  50. A case of millet allergy that developed into wheat-induced anaphylaxis by cross-reaction between millet and wheat antigens, Allergology International, 69(3), 471-473, 202008
  51. High histamine concentrations in human sweat in association with type I allergy to the semi-purified sweat antigen, Allergology International, 69(2), 307-309, 202004
  52. Three cases of advanced cutaneous squamous cell carcinoma treated with a combination of carboplatin and epirubicin, European Journal of Hospital Pharmacy, 27(2), 128-128, 202003
  53. ★, Reduction of serum thymus and activation-regulated chemokine after short-term intensive therapy may predict better prognosis of moderate to severe atopic dermatitis, 46(12), e486-e487, 201912
  54. Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab A study protocol, MEDICINE, 99(38), 20200918
    Link to Paper Search Results by DOI
  55. Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1 beta, JOURNAL OF DERMATOLOGY, 47(11), 1293-1300, 202011
    Link to Paper Search Results by DOI
  56. Calculation of practical skin donor area for meshed skin grafting in real-world surgery, DERMATOLOGIC THERAPY, 33(6), 202011
    Link to Paper Search Results by DOI
  57. Analysis of the long-term economic burden of omalizumab on patients with chronic spontaneous urticaria, JOURNAL OF DERMATOLOGY, 48(1), 56-63, 202101
    Link to Paper Search Results by DOI
  58. Japanese guidelines for atopic dermatitis 2020, ALLERGOLOGY INTERNATIONAL, 69(3), 356-369, 202007
    Link to Paper Search Results by DOI
  59. Survey of actual conditions of erythema marginatum as a prodromal symptom in Japanese patients with hereditary angioedema, WORLD ALLERGY ORGANIZATION JOURNAL, 14(2), 202102
    Link to Paper Search Results by DOI
  60. Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria, ALLERGY, 75(4), 971-974, 202004
    Link to Paper Search Results by DOI
  61. ★, The relationship between the development of erythroderma in patients with atopic dermatitis and the avoidance of anti-inflammatory topical drugs., Allergol Int, 70(3), 376-378, 202107
  62. Iatrogenic cutaneous lymphoid hyperplasia induced by squaric acid dibutyl ester., Contact Dermatitis, 85(1), 88-90, 202107
  63. ★, Time course of disease severity from birth to 19 years old in patients with moderate to severe atopic dermatitis in adulthood., J Dermatol, 48(5), e205-e206, 202105

Invited Lecture, Oral Presentation, Poster Presentation

  1. A web-based epidemiological study of the clinical course of atopic dermatitis in Japan., Akio Tanaka, Satoshi Morioke,Michihiro Hide, Yukihiro Ohya, Naoki Shimojyo, Akira Akazawa., The 44th Annual Meeting of the Japanese Society for Investigative Dermatology, 2019/11, Without Invitation, English, the Japanese Society for Investigative Dermatology, Aomori, Japan
  2. Atopic Dermatitis in France and Japan From Treatment Guidelines to Patient Benefit, Akio Tanaka, France-Japan Joint Workshop for Skin Care in Bordeaux 2019, 2019/09/21, Without Invitation, English, NAOS, Bordeaux, France
  3. Impaired CCL2 expression caused by the OSMR gene mutations in familial primary localized cutaneous amyloidosis, Akio Tanaka, Ryo Saito, Kazue Uchida, Tomoko Kawaguchi, John McGrath, Michihiro Hide, 49th Annual ESDR Meeting, 2019/09, Without Invitation, English, The European Society for Dermatological Research, Bordeaux, France
  4. Japanese Guidelines for Atopic Dermatitis (AD) and clinical experiences with a new drug for AD, Dupilumab, Akio Tanaka, Korean Dermatological Association The 70th Spring Meeting, 2018/04, With Invitation, English
  5. Angioedema in Japan, Akio Tanaka, Korean Academy of Asthma, Allergy and Clinical Immunology, 2017/11/05, With Invitation, English, Korean Academy of Asthma, Allergy and Clinical Immunology, Muju
  6. Hereditary Angioedema - Disease State & Treatment, Akio Tanaka, HAE symposium 2017, 2017/11/03, With Invitation, English, HAE symposium 2017, Seoul
  7. HAE in Japan, Tanaka Akio, Joint Congress of APAAACI & APAPARI 2016., 2016/10/17, With Invitation, English, Kuala Lumpur, Malaysia
  8. Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair., Tanaka A, Matsuo Y, Shimomura Y, Hide M., 46th Annual ESDR Meeting, 2016/09/07, Without Invitation, English, European Society for Dermatological Research, Munich, Germany
  9. Development of a questionnaire for secular change of atopic dermatitis from birth to 19- year-old., Akio Tanaka, Satoshi Morioke, Hiroko Shizukawa, Michihiro Hide, Yukihiro Ohya, Naoki Shimojyo, Akira Akazawa., XXIV World Allergy Congress, 2015/10/14, Without Invitation, English, The World Allergy Organization, Seoul, Korea
  10. A web-based epidemiological study of the clinical course of atopic dermatitis in Japan., Akio Tanaka, Satoshi Morioke, Hiroko Shizukawa, Michihiro Hide, Yukihiro Ohya, Naoki Shimojyo, Akira Akazawa., 2015/05/26, Without Invitation, English
  11. HAE in Japan., Tanaka Akio, 2013 Asia Pacific Congress of Allergy, Asthma, and Clinical Immunology., 2013, With Invitation, English, Taipei, Taiwan
  12. Pruritus and Amyloidosis., Tanaka Akio, 6th World Congress on Itch 2011, 2011, With Invitation, English, Brest, France

Awards

  1. 2012/05/12, SID/JSID Young Fellow Collegiality Awards, The Japanese Society for Investigative Dermatology

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI, 2014, 2016
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  2. KAKENHI(Grant-in-Aid for Scientific Research (C)), 2019, 2021

Social Activities

History as Committee Members

  1. Councilor, 2015/06/19, 2018/06, The Japanese Society for Investigative Dermatology