Hidetoshi Tahara

Last Updated :2024/12/10

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
toshihiroshima-u.ac.jp
Other Contact Details
Kasumi 1-2-3, Minami-ku, Hiroshima, Japan
TEL : (+81)82-257-5290 FAX : (+81)82-257-5294
Self-introduction
My research fields are Telomere, microRNA and exosome in aging and cancer.

Basic Information

Major Professional Backgrounds

  • 2021/01/27, PURMX Therapeutics Inc., CEO
  • 2022/10/01, Hiroshima University, PSI GMP Education and Research Center, Director
  • 2012/04/01, 2020/03/31, MiRTeL.Co.Ltd., Chairman, Chief Executive Officer
  • 2008/04/01, Japanese Cancer Association (JCA), Councilor
  • 2008/04/01, Japanese Association for RNA interferences, President
  • 2021/04/01, Hiroshima University, Vice President (Academia-Government-Industry Collaboration)
  • 2019/04/01, 2021/03/31, Hiroshima University, Deputy Executive Director
  • 2019/04/01, Graduate School of Biomedical and Health Sciences, Hiroshima University, Professor
  • 2018/04/01, 2021/03/31, Graduate School of Biomedical & Health Sciences, Hiroshima University, Vice Dean
  • 2017/04/01, Graduate School of Biomedical & Health Sciences, Hiroshima University, Professor
  • 2017/04/01, 2019/03/31, Hiroshima University, The center of Biomarker and Drug Discovery, Head
  • 2016/04/01, School of Pharmaceutical Sciences, Hiroshima University, Program of Pharmaceutical Sciences, Head of Program
  • 2016/04/01, 2018/03/31, Institute of Biomedical & Health Sciences, Hiroshima University, Head, Basic Life Sciences, Head
  • 2014/04/01, 2006/03/31, Graduate School of Biomedical & Health Sciences, Hiroshima University, Department of Cellular and Molecular Biology, Professor
  • 2006/04/01, 2014/03/31, Graduate School of Biomedical Sciences, Department of Cellular and Molecular Biology, Division of Integrated Medical Science, Program for Biomedical Research, Professor
  • 2001/04/01, 2005/03/31, Faculty of Medicine, Hiroshima University, Institute of Pharmaceutical Sciences, Research Associate
  • 1998/01/01, 2000/01/31, National Institute of Health (NIH), National Institute of Environmental Health Sciences, Visiting Fellow
  • 1994/10/01, 2001/03/31, Faculty of Medicine, Hiroshima University, Institute of Pharmaceutical Sciences, Research Associate

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1991/04, 1994/03
  • Tokyo University of Pharmacy and Life Science, Faculty of Pharmaceutical Science, Japan, 1985/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

Research Fields

  • Biological Sciences;Oncology;Tumor biology
  • Biological Sciences;Oncology;Tumor diagnostics

Research Keywords

  • Telomerase
  • Immortalization
  • Telomere
  • Cellular senescence
  • microRNA
  • Exosome
  • Extracellular vesicles
  • Biomarker

Affiliated Academic Societies

  • International Society for Extracellular Vesicles
  • Japanese Foundation for Cancer Research
  • International Society of Personalized Medicine
  • The Japanese Tissue Culture Association
  • Japanese Society of Anti-Aging Medicine
  • American Assciation for Cancer Research
  • The Japanese Association for Molecular Target Therapy of Cancer
  • Japanese RNAi association, 2008
    Related URL
  • Japanese Society of Extracellular Vesicles, 2014

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, 3Term, Biochemistry V
  2. 2024, Undergraduate Education, Intensive, Biochemistry V
  3. 2024, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  4. 2024, Undergraduate Education, First Semester, Research Practice A
  5. 2024, Undergraduate Education, Second Semester, Research Practice B
  6. 2024, Undergraduate Education, First Semester, Practice of xenobiotics and molecular toxicology
  7. 2024, Undergraduate Education, 4Term, Biochemistry VI
  8. 2024, Undergraduate Education, Intensive, Biochemistry VI
  9. 2024, Undergraduate Education, 4Term, Cell Biology
  10. 2024, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  11. 2024, Undergraduate Education, Second Semester, Experiments of Cellular and Molecular Biology
  12. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  13. 2024, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  14. 2024, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  15. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  16. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  17. 2024, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  18. 2024, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  19. 2024, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  20. 2024, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  21. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular and Molecular Biology
  22. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular and Molecular Biology
  23. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular and Molecular Biology
  24. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular and Molecular Biology
  25. 2024, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  26. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  27. 2024, Graduate Education (Master's Program) , First Semester, Seminar on Cell Regeneration
  28. 2024, Graduate Education (Master's Program) , Second Semester, Seminar on Cell Regeneration
  29. 2024, Graduate Education (Master's Program) , First Semester, Research on Cell Regeneration
  30. 2024, Graduate Education (Master's Program) , Second Semester, Research on Cell Regeneration
  31. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular and Molecular Biology for Medicinal Sciences
  32. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular and Molecular Biology for Medicinal Sciences
  33. 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular and Molecular Biology for Medicinal Sciences
  34. 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular and Molecular Biology for Medicinal Sciences

Research Activities

Academic Papers

  1. Assessment of the expression of microRNAs-221-3p,-146a-5p,-16-5p and BCL2 in oncocytic carcinoma of the breast: A case report, ONCOLOGY LETTERS, 26(6), 202312
    Link to Paper Search Results by DOI
  2. Co-printing of micro/nanostructures integrated with preconcentration to enhance protein detection, MICROFLUIDICS AND NANOFLUIDICS, 28(1), 202401
    Link to Paper Search Results by DOI
  3. Changes in Multiple microRNA Levels with Antidepressant Treatment Are Associated with Remission and Interact with Key Pathways: A Comprehensive microRNA Analysis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(15), 202308
    Link to Paper Search Results by DOI
  4. Relationship between circulating mitochondrial DNA and microRNA in patients with major depression, JOURNAL OF AFFECTIVE DISORDERS, 339, 538-546, 20231015
    Link to Paper Search Results by DOI
  5. Immunocyte Derived Exosomes: Insight into the Potential Chemo- immunotherapeutic Nanocarrier Targeting the Tumor Microenvironment, ACS BIOMATERIALS SCIENCE & ENGINEERING, 9(1), 20-39, 20230109
    Link to Paper Search Results by DOI
  6. Plasma MicroRNAs as noninvasive diagnostic biomarkers in patients with Brugada syndrome, PLOS ONE, 17(5), 20220526
    Link to Paper Search Results by DOI
  7. Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence, JOURNAL OF CLINICAL MEDICINE, 11(24), 202212
    Link to Paper Search Results by DOI
  8. Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(7), 202204
    Link to Paper Search Results by DOI
  9. Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome, STEM CELL RESEARCH, 53, 202105
    Link to Paper Search Results by DOI
  10. Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan, SCIENTIFIC REPORTS, 12(1), 20220214
    Link to Paper Search Results by DOI
  11. Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines, ONCOLOGY, 70(6), 458-464, 2006
    Link to Paper Search Results by DOI
  12. Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development, CANCER SCIENCE, 101(7), 1678-1685, 201007
    Link to Paper Search Results by DOI
  13. Increased telomerase activity and hTERT expression in human salivary gland carcinomas, ONCOLOGY LETTERS, 2(5), 845-850, 2011
    Link to Paper Search Results by DOI
  14. Two unrelated patients with MRE1 1A mutations and Nijmegen breakage syndrome-like severe microcephaly, DNA REPAIR, 10(3), 314-321, 20110307
    Link to Paper Search Results by DOI
  15. miR-22 represses cancer progression by inducing cellular senescence, JOURNAL OF CELL BIOLOGY, 193(2), 409-424, 20110418
    Link to Paper Search Results by DOI
  16. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair, NATURE GENETICS, 44(5), 593-+, 201205
    Link to Paper Search Results by DOI
  17. Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential, BMC MUSCULOSKELETAL DISORDERS, 13, 20120402
    Link to Paper Search Results by DOI
  18. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(46), 38716-38728, 20121109
    Link to Paper Search Results by DOI
  19. The role of exosomes and microRNAs in senescence and aging, ADVANCED DRUG DELIVERY REVIEWS, 65(3), 368-375, 201303
    Link to Paper Search Results by DOI
  20. Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1, CELL REPORTS, 3(5), 1651-1662, 201305
    Link to Paper Search Results by DOI
  21. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology, Pathol. Int., 49, 763-774, 19990401
  22. DNA-DNA Subtractive cDNA cloning using Oigo (dt)(30) -Latex and PCR-identification of cellular genes which are overexpressed in senescent human diploid fibroblasts., Anal Biochem, 214, 58-64, 19930401
  23. Preparation of subtractive cDNA library enriches in cDNAs which expressed at high level in cultured senescent human fibroblasts, Biochem. Biophys. Res. Commun., 199, 1108-1112, 19940401
  24. Telomerase activity in human liver tissues : Comparison between chronic liver disease and hepato cellular carcinoma., Cancer Research, 55, 2734-2736, 19950401
  25. Increase in expression level of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan, Oncogene, 10, 1125-1132, 19950401
  26. Inhibitors of cGMP-dependent protein kinase block seescence induced by inactivation of T antigen in SV40-fransformed immortal human fibroblasts, Oncogene, 11, 627-634, 19950401
  27. Telomerase activity in preneoplastic and neoplastic gastric and colovectal lesions, Clinical Cancer Research, 1, 1245-1251, 19950401
  28. Telomerase, 23, 247-256, 19960401
  29. A hVti1 homologue : Its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts., Biochem. Biophys. Res. Commun., 247, 70-74, 19980401
  30. Telomerase activation by the catalytic component gene TRT in human primary fibroblasts and hepatocellular carcinomas., Nature genetics, 18, 65-68, 19980401
  31. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity., Int J Oncol, 11, 139-143, 19970401
  32. Immortakization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity., Differentiation, 62, 203-211, 19970401
  33. Telomerase activity in ovarian tumors., Cancer, 80, 1085-1092, 19970401
  34. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinomas., Int J Cancer, 74, 141-147, 19970401
  35. Loss of amplified telomeric sequences associated with senescence in telomerasenegative SUSM-1 cells by introduction of human chromosome 7., Exp Cell Res, 235, 345-353, 19970401
  36. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay(HPA)connected with telomeric repeat amplification protocol(TRAP)., J. Cancer Res. Oncol., 123, 337-344, 19970401
  37. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinogenesis, Jpn.J.Cancer Res., 1187-1194, 19980401
  38. Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation., Surg. Neural, 267-274, 20000401
  39. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker., J Neurosurg, 618-625, 20000401
  40. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis, Cancer Letters, 149, 125-134, 20000401
  41. Inhibition of membrane Ca2+ ATPase of Saccharomyces cerevisiae by mating pheromone a factor in vitro, J. Gen. Microbiol.=, 137, 1-4, 19920401
  42. Expression of telomerase component genes in hepatocellular carcinomas., Eur. J. Cancer, 36, 496-502, 20000401
  43. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues., Oncogene, 19, 3888-3893, 20000401
  44. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker., J Neurosurg, 93, 618-625, 20000401
  45. Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity., J. Neurooncol., 47, 39-46, 20000401
  46. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections., Oncogene, 18, 1561-1567, 19990401
  47. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach., Jpn.J.Cancer Res., 90, 589-595, 19990401
  48. Telomerase activity in central nervous system malignant lymphoma., Cancer, 86, 1050-1055, 19990401
  49. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality., Mech. Ageing Dev., 110, 175-193, 19990401
  50. Quantitative re-evaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues., Mol. Carcinog., 26, 312-320, 19990401
  51. Telomerase activation by the catalytic component gene TRT in human primary fibroblasts and hepatocelluar carcinomas., Nature Genet., 18, 65-68, 19980401
  52. Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines., Biochem. Biophys. Res. Commun., 247, 765-772, 19980401
  53. A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts., Biochem. Biophys. Res. Commun., 247, 70-74, 19980401
  54. A new method to detect and measure telomerase activity by transcription-mediated amplification (TMA) and hybridization protection assay (HPA)., Clinical Chem., 44, 2446-2452, 19980401
  55. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions., Jpn.J.Cancer Res., 89, 1099-1103, 19980401
  56. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas., Jpn.J.Cancer Res., 89, 1187-1194, 19980401
  57. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity., Int J Oncol, 11, 139-143, 19970401
  58. Telomerase activity in ovarian tumors., Cancer, 80, 1085-1092, 19970401
  59. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinomas., Int J Cancer, 74, 141-147, 19970401
  60. Loss of amplified telomeric sequences associated with senescence in telomerase-negative SUSM-1 cells by introduction of human chromosome 7., Exp Cell Res, 235, 345-353, 19970401
  61. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay (HPA) connected with telomeric repeat amplification protocol (TRAP)., J Cancer Res Clin Oncol, 123, 337-344, 19970401
  62. Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity., Diffrentiation, 52, 203-211, 19970401
  63. Telomerase in hepatocellular carcinogenesis., Human Cell, 9, 283-286, 19960401
  64. Telomerase activity in normal human epithelial cells., Oncogene, 13, 433-439, 19960401
  65. Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens, including fine needle aspirates., Int J Cancer, 69, 301-306, 19960401
  66. Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas., Cancer Res., 55, 2734-2736, 19950401
  67. Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts., Oncogene, 10, 835-840, 19950401
  68. Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan., Oncogene, 11, 1125-1132, 19950401
  69. Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts., Oncogene, 11, 627-634, 19950401
  70. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3., Jpn.J.Cancer Res., 86, 899-904, 19950401
  71. Telomerase activity in precancerous and cancerous lesions of gastric and colorectal tissues., Clinical Cancer Res., 1, 1245-1251, 19950401
  72. Preparation of a substractive cDNA library enriched in cDNAs which expressed at a high level in cultured senescent human fibroblasts., Biochem. Biophys. Res. Commun., 199, 1108-1112, 19940401
  73. DNA-DNA subtractive cDNA cloning using oligo(dT)30-latex and PCR: Identification of cellular genes which are overexpressed in senescent human diploid fibroblasts., Anal Biochem, 214, 58-64, 19930401
  74. Telomerase activity in various precancerous and cancer tissues, The Proceedings of 87th Annual Meeting of the American Association for Cancer Reserch, 19960401
  75. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 20010401
  76. Distinct pattern of p53 phosphorylation in human tumors, Oncogene, 20(26), 3341-3347, 20010401
  77. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis, Cancer Letters, 149(2001/01/02), 125-134, 20000401
  78. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker, Journal of Neurosurgery, 93(4), 618-625, 20000401
  79. Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity, Journal of Neuro-Oncology, 47(1), 39-46, 20000401
  80. Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation, Surgical Neurology, 53(3), 267-274, 20000401
  81. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues, Oncogene, 19(34), 3888-3893, 20000401
  82. Immortalization of mammary cells from estrogen receptor alpha knock-out and wild-type mice, In Vitro Cellular of Developmental Biology, 36(10), 620-624, 20000401
  83. Expression of telomerase component genes in hepatocellular carcinomas, European Journal of Cancer, 36(4), 496-502, 20000401
  84. Cloning of a human hepatocyte growth factor/scatter factor transcription variant from a gastric cancer cell line HSC-39, INTERNATIONAL JOURNAL OF ONCOLOGY, 16(1), 105-108, 20000401
  85. Telomerase activity in central nervous system malignant lymphoma, Cancer, 86(6), 1050-1055, 19990401
  86. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality, Mechanisms of Ageing and Development, 110(3), 175-193, 19990401
  87. Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines, Biochemical and Biophysical Research Communications, 255(3), 753-758, 19990401
  88. Quantitative reevaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues, Molecular Carcinogenesis, 26(4), 312-320, 19990401
  89. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections, Oncogene, 18(8), 1561-1567, 19990401
  90. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology, Pathology International, 49(9), 763-774, 19990401
  91. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach, Japanese Journal of Cancer Research, 90(6), 589-595, 19990401
  92. Telomerase activity in lesions of the thyroid: Application to diagnosis of clinical samples including fine-needle aspirates, Clinical Cancer Research, 4(8), 1965-1970, 19980401
  93. New method to measure telomerase activity by transcription-mediated amplification and hybridization protection assay, Clinical Chemistry, 44(12), 2446-2452, 19980401
  94. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions, Japanese Journal of Cancer Research, 89(11), 1187-1194, 19980401
  95. A hVti1 homologue: Its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts, Biochemical and Biophysical Research Communications, 247(1), 70-74, 19980401
  96. Diagnostic value of telomerase activity in gynecologic malignancies, International Journal of Gynecological Cancer, 8(6), 481-488, 19980401
  97. ★, Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas, Nature genetics, 18(1), 65-68, 19980401
  98. A quantitative method to measure telomerase activity by hybridization protectin assay (HPA) connected with TRAP for the diagnosis of hepatocellular carcinoma (HCC)., Gastroenterology, 114(4), A1351-A1351, 19980401
  99. Extra-chromosome telomere repeat DNA in telomerase-negative immortalized cell lines, Biochemical and Biophysical Research Communications, 247(3), 765-772, 19980401
  100. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas, Japanese Journal of Cancer Research, 89(11), 1099-1103, 19980401
  101. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay connected with a telomeric repeat amplification protocol, Journal of Cancer Research and Clinical Oncology, 123(6), 337-344, 19970401
  102. Telomerase activity in premalignant and malignant lesions of human oral mucosal, 6(6), 413-420, 19970401
  103. Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity, Differentiation, 62(4), 203-211, 19970401
  104. Expression of human telomerase RNA is an early event of stomach carcinogenesis, Japanese Journal of Cancer Research, 88(2), 103-107, 19970401
  105. Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27(Kip1) in a human gastric carcinoma cell line, 8(1), 47-52, 19970401
  106. Telomerase activity in ovarian tumors, Cancer, 80(6), 1085-1092, 19970401
  107. Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1, Experimental Cell Research, 235(2), 345-353, 19970401
  108. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity, INTERNATIONAL JOURNAL OF ONCOLOGY, 11(1), 139-143, 19970401
  109. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma, International journal of cancer, 74(2), 141-147, 19970401
  110. Modified trap assay for the diagnosis of small differentiated hepatocellular carcinoma (HCC)., Gastroenterology, 112(4), A1344-A1344, 19970401
  111. Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine, Cancer, 79(2), 362-369, 19970401
  112. Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells, Jpn.J.Cancer Res., 87(4), 377-384, 19960401
  113. Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines, Jpn.J.Cancer Res., 87(8), 824-830, 19960401
  114. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence, Mol. Cell. Biol., 16(3), 859-867, 19960401
  115. Telomerase in hepatocellular carcinogenesis, Hum Cell, 9(4), 283-286, 19960401
  116. Telomerase activity in human breast cancer and benign breast lesions: diagnostic applications in clinical specimens, including fine needle aspirates, Int J Cancer, 69(4), 301-306, 19960401
  117. Molecular biological observations in gastric cancer, Semin Oncol, 23(3), 307-315, 19960401
  118. Telomerase activity in normal human epithelial cells, Oncogene, 13(2), 433-439, 19960401
  119. Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts, Oncogene, 11(4), 627-634, 19950401
  120. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3, Jpn.J.Cancer Res., 86(10), 899-904, 19950401
  121. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions, Clin. Cancer Res., 1(11), 1245-1251, 19950401
  122. Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan, Oncogene, 11(6), 1125-1132, 19950401
  123. ★, Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas, Cancer Res., 55(13), 2734-2736, 19950401
  124. ★, Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts, Oncogene, 10(5), 835-840, 19950401
  125. Preparation of a subtractive cDNA library enriched in cDNAs which expressed at a high level in cultured senescent human fibroblasts, Biochem. Biophys. Res. Commun., 199(3), 1108-1112, 19940401
  126. DNA-DNA subtractive cDNA cloning using oligo(dT)30-Latex and PCR: identification of cellular genes which are overexpressed in senescent human diploid fibroblasts, Anal Biochem, 214(1), 58-64, 19930401
  127. Genetic Status and Expression of the Cyclin-dependent Kinase Inhibitors in Human Gastric Carcinoma cell Lines, Jpn.J.Cancer Res., 87, 824-830, 19960101
  128. Expression of CDK inhibitor p21 and CDK2 in human colorectal carcinoma cell lines: relation with p53 status, Recent Advances in Gastroenterological Carcinogenesis., 749-753
  129. Involvement of telomere shortening and telomerase in cell aging and immortalization (M. Goto Ed.),, 147-163, 20010401
  130. Telomere and telomerase in Gastrointestinal cancers, 245-259., 19970401
  131. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas., Pathobiology, 69, 219-224, 20010401
  132. Expression and distribution of human telomerqase catalytic component, hTERT, in human breast tissues., Anticancer Research, 22, 4101-4108, 20020401
  133. In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformd by Epstein-Barr virus., DNA and Cell Biology, 20030401
  134. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus., Cancer Research, 64, 3361-3364, 20040401
  135. WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus. Cancer Genet., Cytogenet., 152, 95-100, 20040401
  136. Establishment of lifespan-extended human astrocytes with normal phenotypes by introduction of telomerase gene., Tissue Cult. Res. Commun., 23, 59-69, 20040401
  137. Telomeres and telomerase in hepatocellular carcinoma., Recent Res. Devel. Cancer, 6, 191-210, 20040401
  138. Terminal telomere repeats are actually short in telomerase-negative immortal human cells., Biol. Pharm. Bull., 27, 1932-1938, 20040401
  139. G1P3, An interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial mediated apoptosis in gastric cancer cell line TMK-1., Cancer Immunol. Immunoth., 54(8), 729-740, 20050401
  140. Establishment of cementoblast cell lines from rat cementum lining cells by transfection with temperature-sensitive simian virus-40 T-antigen gene., BONE, 37, 220-226, 20050401
  141. Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation., Stem Cells Dev, 15(6), 921-929, 20061201
  142. Immortalization and characterization of human dental pulp cells with odontoblastic differentiation., Archives of Oral Biology, 52(8), 727-731, 20070801
  143. Characterization of established cementoblast-like cell lines from human cementum lining cells in vitro and in vivo., Bone, 39(5), 1035-1042, 20061101
  144. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells., Biochemical and biophysical research communications, 926-932, 20070223
  145. Terminal telomere repeats are actually short in telomerase-negative immortal human cells., Biological & Pharmaceutical Bulletin, 27, 1932-1938, 20041201
  146. ★, G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells., Oncogene, 25(13), 1955-1966, 20060323
  147. Establishment of immortalized clonal cells derived from periodontal ligament cells by induction of the hTERT gene., Journal of Oral Science, 47(4), 177-184, 20051201
  148. ★, G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs, Nature Methods, 2(11), 829-831, 20051101
  149. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres., Cell, 126(1), 49-62, 20060714
  150. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination., European Molecular Biology Organization, 25(21), 5180-5190, 20061101
  151. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence., Nature Cell Biology, 8(11), 1291-1297, 20061101
  152. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome., American Journal of Medical Genetics, 140(4), 358-367, 20060215
  153. Quantitative proteomic analysis of human breast epithelial cells with differential telomere length, BBRC, 356(4), 942-947, 20070318
  154. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells., BBRC, 353(4), 926-932, 20070223
  155. Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene., International Journal Of Oncology, 31(2), 339-344, 20070801
  156. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3., Biochem. Biophys. Res. Commun., 337(1), 201-208, 20051111
  157. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly., DNA Repair (Amst), 20110301
  158. Telomere G-Overhang Length Measurement Method 2: G-Tail Telomere HPA, Methods in Molecular Biology, 735, 55-61, 20110301
  159. Introduction of a Single Transporter Gene ABCA3 Directs RLE–6TN to More Type II–like Alveolar Epithelial Cells, MEMBRANE, 38(5), 246-253, 20130801
  160. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker, JOURNAL OF NEUROSURGERY, 93(4), 618-625, 200010
    Link to Paper Search Results by DOI
  161. Distinct pattern of p53 phosphorylation in human tumors, ONCOGENE, 20(26), 3341-3347, 20010607
    Link to Paper Search Results by DOI
  162. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 200109
    Link to Paper Search Results by DOI
  163. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas, PATHOBIOLOGY, 69(4), 219-224, 2001
    Link to Paper Search Results by DOI
  164. Association of p16(INK4a) and pRb inactivation with immortalization of human cells, CARCINOGENESIS, 23(12), 2111-2117, 200212
    Link to Paper Search Results by DOI
  165. Expression and distribution of human telomerase catalytic component, hTERT, in human breast tissues, ANTICANCER RESEARCH, 22(6C), 4101-4107, 2002
    Link to Paper Search Results by DOI
  166. In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, DNA AND CELL BIOLOGY, 22(11), 727-735, 200311
    Link to Paper Search Results by DOI
  167. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, CANCER RESEARCH, 64(10), 3361-3364, 20040515
    Link to Paper Search Results by DOI
  168. WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, CANCER GENETICS AND CYTOGENETICS, 152(2), 95-100, 20040715
    Link to Paper Search Results by DOI
  169. Terminal telomere repeats are actually short in telomerase-negative immortal human cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 27(12), 1932-1938, 200412
    Link to Paper Search Results by DOI
  170. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell, CANCER IMMUNOLOGY IMMUNOTHERAPY, 54(8), 729-740, 200508
    Link to Paper Search Results by DOI
  171. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 337(1), 201-208, 20051111
    Link to Paper Search Results by DOI
  172. G-taff teLomere HPA: simple measurement of human single-stranded telomeric overhangs, NATURE METHODS, 2(11), 829-831, 200511
    Link to Paper Search Results by DOI
  173. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 140A(4), 358-367, 20060215
    Link to Paper Search Results by DOI
  174. G-quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3 ' telomeric overhang in cancer cells, ONCOGENE, 25(13), 1955-1966, 20060323
    Link to Paper Search Results by DOI
  175. Telomere and telomerase in age related diseases, SEIKAGAKU, 78(3), 230-241, 200603
    Link to Paper Search Results by DOI
  176. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres, CELL, 126(1), 49-62, 20060714
    Link to Paper Search Results by DOI
  177. Mitogenic signalling and the p16(INK4a)-Rb pathway cooperate to enforce irreversible cellular senescence, NATURE CELL BIOLOGY, 8(11), 1291-U63, 200611
    Link to Paper Search Results by DOI
  178. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 353(4), 926-932, 20070223
    Link to Paper Search Results by DOI
  179. Characterization of established cementoblast-like cell lines from human cementum-lining cells in vitro and in vivo, BONE, 39(5), 1035-1042, 200611
    Link to Paper Search Results by DOI
  180. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination, EMBO JOURNAL, 25(21), 5180-5190, 20061101
    Link to Paper Search Results by DOI
  181. Quantitative proteomic analysis of human breast epithelial cells with differential telomere length, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 356(4), 942-947, 20070518
    Link to Paper Search Results by DOI
  182. Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation, EXPERIMENTAL CELL RESEARCH, 314(5), 1115-1124, 20080310
    Link to Paper Search Results by DOI
  183. Role of menin in the regulation of telomerase activity in normal and cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(2), 333-340, 200808
    Link to Paper Search Results by DOI
  184. A Chiral Wedge Molecule Inhibits Telomerase Activity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(11), 3778-3782, 20100324
    Link to Paper Search Results by DOI
  185. Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops, AGING-US, 2(5), 274-284, 201005
    Link to Paper Search Results by DOI
  186. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 20101022
    Link to Paper Search Results by DOI
  187. MicroRNAs in Cancer: The 22nd Hiroshima Cancer Seminar/The 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 43(5), 579-582, 201305
    Link to Paper Search Results by DOI
  188. Generation of Human Induced Pluripotent Stem (Ips) Cells in Serum- and Feeder-Free Defined Culture and TGF-B1 Regulation of Pluripotency, PLOS ONE, 9(1), 20140129
    Link to Paper Search Results by DOI
  189. CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break-Specific G(2) Checkpoint, CANCER RESEARCH, 74(14), 3880-3889, 20140715
    Link to Paper Search Results by DOI
  190. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, 20140502
    Link to Paper Search Results by DOI
  191. DSE-FRET: A new anticancer drug screening assay for DNA binding proteins, CANCER SCIENCE, 105(7), 870-874, 201407
    Link to Paper Search Results by DOI
  192. Decreased Amyloid-beta Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(35), 24488-24498, 20140829
    Link to Paper Search Results by DOI
  193. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice, PLOS ONE, 9(10), 20141021
    Link to Paper Search Results by DOI
  194. A potential function for neuronal exosomes: Sequestering intracerebral amyloid-beta peptide, FEBS LETTERS, 589(1), 84-88, 20150102
    Link to Paper Search Results by DOI
  195. EVpedia: a community web portal for extracellular vesicles research, BIOINFORMATICS, 31(6), 933-939, 20150515
    Link to Paper Search Results by DOI
  196. Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture, PLOS ONE, 9(11), 20141112
    Link to Paper Search Results by DOI
  197. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 201408
    Link to Paper Search Results by DOI
  198. Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia, AMERICAN JOURNAL OF HUMAN GENETICS, 96(6), 1001-1007, 20150604
    Link to Paper Search Results by DOI
  199. Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study, EBIOMEDICINE, 2(8), 960-967, 201508
    Link to Paper Search Results by DOI
  200. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer, ONCOTARGET, 7(7), 8223-8239, 20160216
  201. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, 20160826
    Link to Paper Search Results by DOI
  202. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper, JOURNAL OF EXTRACELLULAR VESICLES, 6, 2017
    Link to Paper Search Results by DOI
  203. Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming, FRONTIERS IN GENETICS, 6, 20150129
    Link to Paper Search Results by DOI
  204. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles, STEM CELLS TRANSLATIONAL MEDICINE, 6(8), 201708
    Link to Paper Search Results by DOI
  205. Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations, STEM CELLS, 36(3), 434-445, 201803
    Link to Paper Search Results by DOI
  206. Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 498(4), 817-823, 20180415
    Link to Paper Search Results by DOI
  207. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40(6), 915-922, 201806
    Link to Paper Search Results by DOI
  208. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017, JOURNAL OF EXTRACELLULAR VESICLES, 7(1), 20180517
    Link to Paper Search Results by DOI
  209. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement, SCIENTIFIC REPORTS, 8, 20181001
    Link to Paper Search Results by DOI
  210. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells, SCIENTIFIC REPORTS, 8, 20181004
    Link to Paper Search Results by DOI
  211. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, JOURNAL OF EXTRACELLULAR VESICLES, 8(1), 20190101
    Link to Paper Search Results by DOI
  212. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, JOURNAL OF EXTRACELLULAR VESICLES, 7(1), 20181123
    Link to Paper Search Results by DOI
  213. Influence of donor liver telomere and G-tail on clinical outcome after living donor liver transplantation, PLOS ONE, 14(3), 20190307
    Link to Paper Search Results by DOI
  214. Targeting DNA binding proteins for cancer therapy, CANCER SCIENCE, 111(4), 1058-1064, 202004
    Link to Paper Search Results by DOI
  215. Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer, CANCER SCIENCE, 111(5), 1856-1861, 202005
    Link to Paper Search Results by DOI
  216. Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma, PLOS ONE, 15(4), 20200406
    Link to Paper Search Results by DOI
  217. Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles, CANCER SCIENCE, 111(6), 2104-2115, 202006
    Link to Paper Search Results by DOI
  218. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors, SCIENTIFIC REPORTS, 10(1), 20200831
    Link to Paper Search Results by DOI
  219. Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(23), 202012
    Link to Paper Search Results by DOI
  220. Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan, PLOS ONE, 16(2), 20210205
    Link to Paper Search Results by DOI
  221. PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA, JOURNAL OF BIOLOGICAL CHEMISTRY, 297(1), 202107
    Link to Paper Search Results by DOI
  222. The power of imaging to understand extracellular vesicle biology in vivo, NATURE METHODS, 18(9), 1013-1026, 202109
    Link to Paper Search Results by DOI
  223. Peptide-based electrochemical sensor with nanogold enhancement for detecting rheumatoid arthritis, TALANTA, 236, 20220101
    Link to Paper Search Results by DOI
  224. Continuous polymerase chain reaction microfluidics integrated with a gold-capped nanoslit sensing chip for Epstein-Barr virus detection, BIOSENSORS & BIOELECTRONICS, 195, 20220101
    Link to Paper Search Results by DOI
  225. Nanoplasmonic Structure of a Polycarbonate Substrate Integrated with Parallel Microchannels for Label-Free Multiplex Detection, POLYMERS, 13(19), 202110
    Link to Paper Search Results by DOI
  226. A nanofluidic preconcentrator integrated with an aluminum-based nanoplasmonic sensor for Epstein-Barr virus detection, SENSORS AND ACTUATORS B-CHEMICAL, 355, 20220315
    Link to Paper Search Results by DOI
  227. Development of a water refractive index-matched microneedle integrated into a light sheet microscopy system for continuous embryonic cell imaging, LAB ON A CHIP, 22(3), 584-591, 20220201
    Link to Paper Search Results by DOI

Publications such as books

  1. 2001, Involvement of telomere and telomerase in aging and cell immortalization , Cann Monograph on Cancer Research No.49, 2001
  2. 1996, Telomerase activity and genetic changes in human colorectal cancers , New strategies for Treatment of Hereditary colovectal cancers, 1996
  3. 1996, Telomerase activity in gastrointestinal cancers , 1996

Invited Lecture, Oral Presentation, Poster Presentation

  1. Co-Create the Next Value with Bio Ecosystems in Japan, BIO-EUROPE2022, 2022/10/24, Without Invitation, Japanese
  2. Investigator-initiated clinical trial of MIRX002, an anti-tumor nucleic acid medicine for malignant pleural mesothelioma, MOPM2022 conference, 2022/11/19, With Invitation, Japanese
  3. First-in-human investigator-initiated clinical trial of a nucleic acid medicine for malignant pleural mesothelioma, 2022/09/07, With Invitation, Japanese
  4. COVID-19 research at Hiroshima University, Hidetoshi Tahara, 2020/10/08, With Invitation, English, UNIVERSITY OF GOTHENBURG International Centre
  5. Identification of circulating small RNAs as novel biomarkers for breast cancer detection, Yumiko Koi, Yuki Yamamoto, Ryou-u Takahashi, Morihito Okada, Hidetoshi Tahara, 2020/10/03, Without Invitation, Japanese
  6. PRPF19 exerts a functional role in p53-dependent cellular senescence via regulating MDM4 splicing, Kimiyoshi Yano, Shisei Kan, Hiroki Sakagami, Ryou-u Takahashi,Hidetoshi Tahara, 2020/10/03, Without Invitation, Japanese
  7. A treatment of malignant pleural mesothelioma using a novel senescence-associated miRNA miR-3140-3p, Yuki Yamamoto, Kimiyoshi Yano, Noriaki Matsuda, Ryou-u Takahashi, Morihito Okada, Hidetoshi Tahara, 2020/10/03, Without Invitation, Japanese
  8. Pre-mRNA processing factor 19 (PRPF19) as a key regulator inaging and cancer, 2020/10/03, With Invitation, Japanese
  9. The potential for microRNA therapeutics: Pre-clinical study of locally administered miRNA for malignant mesothelioma, 2020/10/03, With Invitation, Japanese
  10. Non-clinical study of locally administered microRNA nucleic acid medicine for malignant pleural mesothelioma, Hidetoshi Tahara, 2019/08/29, With Invitation, Japanese
  11. Circulating small RNAs in the serum as novel biomarkers for breast cancer detection, Yumiko Koi,Yasuhiro Tsutani, Yukie Nishiyama, Shinsuke Sasada, Tomoyuki Akita, NorioMasumoto, Takayuki Kadoya, Ryou-u Takahashi, Junko Tanaka, Morihito Okada, Hidetoshi Tahara, 2019/08/29, Without Invitation, Japanese
  12. Identification of PRPF19 as a novel target gene of senescence-associated microRNA; miR-27b-3p, Kimiyoshi Yano, Shisei Kan, Hiroki Sakagami, Ryou-u Takahashi and Hidetoshi Tahara, 2019/08/29, Without Invitation, Japanese
  13. The development of a novel nucleic acid drug against malignant pleural mesothelioma, Ayaka Nishiura, Yuki Yamamoto, Kimiyoshi Yano, Saori Fukunaga, Issei Shibuya, Ryou-u,Takahashi, Hidetoshi Tahara, 2019/08/28, Without Invitation, Japanese
  14. Senescent cells-derived extracellular vesicles repress tumour growth by transferring miR-127-3p and miR-134-5p., Megumi Okada,Kimiyoshi Yano,Shigeyuki Teranishi,Mariko Ikuo,Hidetoshi Tahara, ISEV2019, 2019/04/27, Without Invitation, English
  15. The factor affecting to the accuracy of extracellular small non-coding RNA biomarkers, Yukie Nishiyama,Yumiko Koi,Genki Nishimura, Eri Kojima,Morihito Okada,Hidetosi Tahara, ISEV2019, 2019/04/27, Without Invitation, English
  16. Isolation and characterization of bovine milk-derived Evs., Saori Fukunaga,Yuki Yamamoto,Hidetoshi Tahara, ISEV2019, 2019/04/26, Without Invitation, English
  17. BMP2 dependent osteoblast defferentiation is suppressed by multiplemyeloma-derived extracellular vesicles, Mariko Ikuo, ISEV2019, 2019/04/26, Without Invitation, English
  18. Characterization of extracellular vesicles (EVs) derived exRNA in cancer using NGS, Hidetoshi Tahara, qPCR dPCR & NGS 2019, 2019/03/18, With Invitation, English, Weihenstephan,Germany
  19. Telomere and microRNA in aging, 2018/10/10, With Invitation, Japanese
  20. MicroRNAs,isomiRs and tRFs are promising biomarkers as liquid biopsy for breast cancer detection., 2018/09/27, Without Invitation, Japanese
  21. A novel mechanism of p53-dependent cellular senescence by silencing of PRPF19, 2018/08/31, Without Invitation, Japanese
  22. Novel Senescence-Associated microRNA suppress malignant pleural mesothelioma, 2018/08/31, Without Invitation, Japanese
  23. A novel mechanism of p53-dependent cellular senescence by silencing of PRPF19, 2018/08/30, Without Invitation, Japanese
  24. Exploration of hemolysis-associated small non-coding RNA by Next Generation Sequence, 2018/08/30, Without Invitation, Japanese
  25. Novel Senescence-Associated microRNA suppress malignant pleural mesothelioma, 2018/08/29, Without Invitation, Japanese
  26. The relationship between human aging and advanced glycation end products of extracellular vesicles in serum., 2018/08/29, Without Invitation, Japanese
  27. Age-related expression change of circulating small non-coding RNAs, 2018/08/29, Without Invitation, Japanese
  28. Extracelluar vesicles derived from senescencet cells repress tumour growth via miRNAs, Mariko Ikuo,Megumi Okada, Shigeyuki Teranishi,Masaki Kinehara,Akira Shimamoto,Hidetoshi Tahara, ISEV2018, 2018/05/05, Without Invitation, English, Barcelona(Reino de España)
  29. Extracelluler small non-coding RNAs as promising biomarkers for early cancer detection, Yukie Nishiyama,Yumiko Koi,Genki Nishimura,Eri Kojima,Morihito Okada,Hidetoshi Tahara, ISEV2018, 2018/05/05, Without Invitation, English, Barcelona(Reino de España)
  30. Development of novel TRF2 inhibitor, Yoshitomo Shiroma,Go Fujita, Hidetoshi Tahara, EMBO Workshop, 2018/05/02, Without Invitation, English, Troia(Portugal)
  31. Application of exRNA and Circulating RNA for Early Detection of Cancer, Hidetoshi Tahara, Extracellular Vesicles as Biomarkers of Disease, 2017/12/13, Without Invitation, English
  32. Senescence cell - derived extracellular vesicles repress tumor growth, 2017/12/09, Without Invitation, Japanese
  33. Senescence cell - derived extracellular vesicles repress tumor growth, 2017/12/08, Without Invitation, Japanese
  34. Small non - coding RNA as biomarker promising early detection of pancreatic cancer, 2017/12/07, Without Invitation, Japanese
  35. Development of inhibitor of telomere binding protein using DSE-FRET assay, 2017/12/07, Without Invitation, Japanese
  36. Discovery and function analysis of RelA-DNA binding inhibitor using NF-kB DSE-FRET assay, 2017/12/07, Without Invitation, Japanese
  37. The association between glycation of sueface proteins on extracellular vesicles in serum and aging, 2017/12/06, Without Invitation, Japanese
  38. Senescence-associated microRNAs suppress malignant pleural mesothelioma cells, 2017/12/06, Without Invitation, Japanese
  39. Nucleic acid medicine based senescence-associated microRNAs for cancer therapy, 2017/12/06, Without Invitation, Japanese
  40. Mechanism of p53 activation via silenceing of PRPF19 in cellular senescence, 2017/12/06, Without Invitation, Japanese
  41. Validation of circulating microRNA using NGS, 2017/11/01, With Invitation, English
  42. "Cancer dormancy induced by Dox-inducible cancer stem cell model is maintained by BMP signaling", 2017/09/30, Without Invitation, Japanese
  43. "Novel senescence-associated microRNAs inhibit proliferation of intractable cancer cells", 2017/09/30, Without Invitation, Japanese
  44. The effect of TRF2 inhibitors in cancer cells, 2017/09/30, Without Invitation, Japanese
  45. PRPF19 is a novel potent molecular target for tumor suppression, 2017/09/30, Without Invitation, Japanese
  46. Senescence-associated microRNAs act as tumor suppressor hor both cancer stem cells and anti-cancer drug cancer cells, Hidetoshi Tahara, 2nd Global Insight Conference on Breast Cancer, 2017/09/05, Without Invitation, English, Rome
  47. Identification of serum preparation method that can get consistent circulating ncRNA profile., 2017/08/31, Without Invitation, Japanese
  48. Next-Generation Sequence analysis of exosomal small RNA isolated from cell culture media., 2017/08/30, Without Invitation, English
  49. miRNA in aging and cancer, 2017/08/28, With Invitation, English
  50. "An in vitro model for cancer stem cell dormancy and recurrence using tetinducible reprogramming system", 2017/07/01, With Invitation, Japanese
  51. Screening of senescence-inducible microRNAs for cancer therapy, 2017/07/01, Without Invitation, Japanese
  52. MicroRNA and exosome in Aging, Hidetoshi Tahara, 2017/06/15, With Invitation, English
  53. Extracellular RNA is promising biomarker for eary detection of cancers, Hidetoshi Tahara, Yukie Nishiyama,Yumiko Koui,Yuki Yamamoto,Genki Nishimura,Masaki Kinehara,Akira Shimamoto,Morito Okada,Hidetoshi Tahara, ISEV2017, 2017/05/19, Without Invitation, English, Toronto,Canada
  54. Circulating microRNAs as novel promising biomarkers for early detection of Tongue Cancer, Hidetoshi Tahara, ESMO ASIA, 2017/01/16, Without Invitation, Japanese, シンガポール
  55. Screening of senescence-associated microRNAs having anti- proliferative effect in human cancer cells, 2016/10/08, Without Invitation, Japanese
  56. Biogenesisandbiologicalactivitiesofexosomesderivedfrom replicative senescent fibroblast cells, 2016/10/08, Without Invitation, Japanese
  57. Application of senescence-inducible microRNAs for cancer therapy, 2016/10/06, With Invitation, Japanese
  58. Induction of cancer stem cell dormancy and recurrence by Dox-inducible secondary reprogramming system, 2016/10/06, Without Invitation, Japanese
  59. The potential for applying PRPF19 siRNA to anti-cancer therapeutics, 2016/09/14, Without Invitation, Japanese
  60. The potential for applying PRPF19 siRNA to anti-cancer therapeutics, 2016/09/01, Without Invitation, Japanese
  61. Functional analysis of exosomal miRNA derived from senescent cells, 2016/08/31, Without Invitation, Japanese
  62. p16-dependent induction of cell death by senescence-inducible microRNA in pancreatic cancer cells., 2016/08/31, Without Invitation, Japanese
  63. Nucleic Acid Therapeutics targeting microRNAs, 2016/07/30, With Invitation, Japanese
  64. The Significant Function Of EVs In Aging And Cancer, Hidetoshi Tahara, Extracellular Vesicles 2016, 2016/07/12, Without Invitation, English, Cambridge, UK
  65. Apoptotic Effect of Senescence-inducible microRNAs on Human Cancer Cell Lines, Masaki Kinehara,Yuki Yamamoto,Saori Fukunaga,Akira Shimamoto,Hidetoshi Tahara, 2016/06/24, Without Invitation, Japanese
  66. Inhibition of cancer cell growth by senescence-inducible miRNA, 2016/05/25, Without Invitation, Japanese
  67. "Non-coding RNAs Senescence-associated EVs from fibroblasts act as tumor suppressor at the tumor microenvironment.", Hidetoshi Tahara, 2016/02/18, Without Invitation, English, other
  68. Depletion of PRPF19 regulates cell fate between cellular senescence and cell death, 2015/12/03, Without Invitation, Japanese, other
  69. Histone variant H3.3 depletion induces cellular senescence in human diploid fibroblasts, 2015/12/02, Without Invitation, Japanese, other
  70. FunctionalanalysisofmiR-486inpancreaticcancer, 2015/10/10, Without Invitation, Japanese, other
  71. DepletionofPRPF19regulatescellfatebetweencellular senescence and cell death, 2015/10/10, Without Invitation, Japanese, other
  72. Thenovelmoleculartargetsforanti-cancerdrugtargeting transcription factors, 2015/10/10, Without Invitation, Japanese, other
  73. Identification of novel senescence-associated microRNAs in human fibroblasts, 2015/10/08, Without Invitation, Japanese, other
  74. Liquid Biopsy by using telomere and microRNA, JASIS2015, 2015/09/04, With Invitation, Japanese, other
  75. miR-486 has potential as nucleic acid medicine, 2015/08/27, Without Invitation, Japanese, published
  76. Senescence associated microRNA suppress cell proliferation in pancreatic cancer, 2015/08/27, Without Invitation, Japanese, published
  77. Understanding the mechanisms of the PRPF19 siRNA-mediated anti-tumor effect, 2015/08/27, Without Invitation, Japanese, published
  78. Cell-derived extracellular vesicle regulates cellular senescence, 2015/08/27, Without Invitation, Japanese, published
  79. The analysis of biological significance of extracellular vesicles in replicative senescence, 2015/08/27, Without Invitation, Japanese, published
  80. Role of phage display technology to proteomics, 2015/07/23, Without Invitation, Japanese, other
  81. Stable propagation of human pluripotent stem cells by dual inhibition of PKC and ERK signaling, 2015/05/26, Without Invitation, Japanese, other
  82. A large-scale membrane proteome analysis in scirrhous gastric cancer cell, 2015/05/26, Without Invitation, Japanese, other
  83. High-content screening of senescence-inducible microRNAs, 2015/05/26, Without Invitation, Japanese, other
  84. Analysis of senescence-associated miRNA that suppress pancreatic cancer, 2015/05/26, Without Invitation, Japanese, other
  85. Generation of Werner syndrome-specific iPS cells and challenges towards clinical application, 2015/05/26, Without Invitation, Japanese, other
  86. DNA Damage Response in Human Induced Pluripotent Stem Cells, Akira Shimamoto,Harunobu Kagawa,Hidehiko Kawai,Tetsushi Sakuma,Takashi Yamamoto,Bunsyo Shiotani,Hidetoshi Tahara, ICRR2015, 2015/05/25, Without Invitation, English, other
  87. Senescence-associated EVs act as tumor suppressors in the tumor microenvironment, Hidetoshi Tahara, International Soclety for Extracellular Vesicies 2015, 2015/04/25, Without Invitation, English, experimental

External Funds

Acceptance Results of Competitive Funds

  1. Promoting Clinical Trials for Development of New Drugs and Medical Devices, 2022//0/4/, 2023//0/3/
  2. Practical Research for Innovative Cancer Control, 2022//0/4/, 2023//0/3/
  3. Practical Research for Innovative Cancer Control, 2021/04/01, 2022/03/31
  4. Practical Research for Innovative Cancer Control, 2015/04/01, 2016/03/31
  5. Program for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), 2015/04/01, 2016/03/31
  6. Project focused on developing key technology of discovering and manufacturing drug for next-generation treatment and diagnosis, 2015/04/01, 2016/03/31
  7. 2011
  8. 2011
  9. 2007
  10. KAKENHI, 2014, 2016
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  11. KAKENHI, 2014, 2015
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  12. KAKENHI, 2014, 2016
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  13. KAKENHI, 2013, 2014
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  14. KAKENHI, Development of novel cancer specific DDS utilizing circulating microRNA-derived mechanism, 2012, 2013
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  15. KAKENHI, Development of novel drug delivery system for micro RNA nucleic biomedicine using exosome from human cultured cells, 2011, 2011
    Permalink
  16. KAKENHI, The CD47-SIRPa signaling blockade accelerates macrophage phagocytic activity against cancer cells, 2011, 2013
    Permalink
  17. KAKENHI, Mechanism of senescence-associated microRNA inhibiting cell growth and metastasis, 2011, 2013
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  18. KAKENHI, Mechanism of cancer-selective cell death induced by increased genomic instability and application of the cell death mechanism to cancer therapy, 2008, 2010
    Permalink
  19. KAKENHI, 2008, 2009
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  20. KAKENHI, Risk assessment of cancer using telomere G-tail length measurement, 2008, 2009
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  21. KAKENHI, Optimal therapeutic approach on ischemic brain insult using bone marrow stromal cells cultured under simulated microgravity, 2008, 2010
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  22. KAKENHI, Discovery of the new anti-cancer drug candidates from Okinawan subtropical plants., 2008, 2010
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  23. KAKENHI, Mesenchymal stem cells dynamism in microgravity environment., 2007, 2009
    Permalink
  24. KAKENHI, 2007, 2008
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  25. KAKENHI, Elucidation of the consequence of telomere single-stand overhang, G-tail, in biology, and application to age-related disease, 2006, 2007
    Permalink
  26. KAKENHI, 2006, 2007
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  27. KAKENHI, Identification of compounds that induce or repress telomerase activity, 2003, 2004
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  28. KAKENHI, 2003, 2004
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  29. KAKENHI, Do telomere regulate in vivo aging?, 2000, 2001
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  30. KAKENHI, Cloning and clinical application of telomerase cDNA, 1997, 1998
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  31. KAKENHI, 1996, 1996
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  32. KAKENHI, 1995, 1995
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  33. KAKENHI, 1995, 1995
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  34. KAKENHI, cDNA cloning of cellular aging and cellular senescence, 1995, 1996
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  35. Health and Labour Sciences Research Grants, 2014/05/01, 2015/03/31
  36. KAKENHI, 2010, 2014
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  37. Practical Research for Innovative Cancer Control , 2016/04/01, 2017/03/31
  38. Practical Research for Innovative Cancer Control , 2017/04/01, 2018/03/31
  39. Translational Research Network Program, 2017/07/01, 2018/03/31
  40. Project focused on developing key technology of discovering and manufacturing drug for next-generation treatment and diagnosis , 2017/04/01, 2018/03/31
  41. Practical Research for Innovative Cancer Control , 2018/04/01, 2019/03/31
  42. Translational Research Network Program, 2018/04/01, 2019/03/31
  43. Project focused on developing key technology of discovering and manufacturing drug for next-generation treatment and diagnosis , 2018/04/01, 2019/03/31
  44. Practical Research for Innovative Cancer Control , 2019/04/01, 2020/03/31
  45. Practical Research for Innovative Cancer Control, 2020/04/01, 2021/03/31

Social Activities

Organizing Academic Conferences, etc.

  1. Japanese Association for RNAi, 2023/, 2023/
  2. Japanese Association for RNAi, 2024/08, 2024/08
  3. Japanese Association for RNAi, 2022/, 2022/
  4. Japanese Association for RNAi, 2021/, 2021/
  5. Japanese Association for RNAi, 2019/, 2019/
  6. 2018/08, 2018/08
  7. The 9th JARI Annual Meeting, 2017/08, 2017/09
  8. The 8th JARI Annual Meeting, 2016/08, 2016/08
  9. The 7th JARI Annual Meeting, 2015/08, 2015/08
  10. 2014/, 2014/
  11. 2013/, 2013/
  12. 2012/08
  13. International Society for Extracellular Vesicles, 2018/, 2018/
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  14. International Society for Extracellular Vesicles, ISEV2019 INTERNATIONAL ORGANIZING COMMITTEE Chair, 2019/04, 2019/04
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History as Peer Reviews of Academic Papers

  1. 2022, Cancer Science, Editor, 15