Hidetoshi Tahara

Last Updated :2022/09/02

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
toshihiroshima-u.ac.jp
Self-introduction
My research fields are Telomere, microRNA and exosome in aging and cancer.

Basic Information

Major Professional Backgrounds

  • 2000/05/01, 2001/03/31
  • 1994/10/01, 2000/04/30
  • 2006/04/01
  • 2002/04/01, 2006/03/31
  • 2002/04/01, 2006/03/31
  • 2001/04/01, 2002/03/31

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1991/04, 1994/03
  • Tokyo University of Pharmacy and Life Science, Faculty of Pharmaceutical Science, Japan, 1985/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

Research Fields

  • Biological Sciences;Oncology;Tumor biology
  • Biological Sciences;Oncology;Tumor diagnostics

Research Keywords

  • Telomerase
  • Immortalization
  • Telomere
  • Cellular senescence
  • microRNA
  • Exosome
  • Extracellular vesicles
  • Biomarker

Affiliated Academic Societies

  • American Assciation for Cancer Research
  • Japanese RNAi association, 2008
  • Japanese Society of Extracellular Vesicles, 2014

Educational Activity

Course in Charge

  1. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  2. 2022, Graduate Education (Master's Program) , First Semester, Seminar on Cell Regeneration
  3. 2022, Graduate Education (Master's Program) , Second Semester, Seminar on Cell Regeneration
  4. 2022, Graduate Education (Master's Program) , First Semester, Research on Cell Regeneration
  5. 2022, Graduate Education (Master's Program) , Second Semester, Research on Cell Regeneration
  6. 2022, Undergraduate Education, 3Term, Biochemistry V
  7. 2022, Undergraduate Education, Intensive, Biochemistry V
  8. 2022, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  9. 2022, Undergraduate Education, First Semester, Practice of xenobiotics and molecular toxicology
  10. 2022, Undergraduate Education, 4Term, Biochemistry VI
  11. 2022, Undergraduate Education, 4Term, Cell Biology
  12. 2022, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  13. 2022, Undergraduate Education, Second Semester, Experiments of Cellular and Molecular Biology
  14. 2022, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I
  15. 2022, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  16. 2022, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  17. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  18. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  19. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  20. 2022, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  21. 2022, Graduate Education (Doctoral Program) , 3Term, Advanced Lecture on Creation and Development of Biomedical Sciences
  22. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cellular and Molecular Biology
  23. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cellular and Molecular Biology
  24. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced research on Cellular and Molecular Biology
  25. 2022, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  26. 2022, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  27. 2022, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  28. 2022, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  29. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular and Molecular Biology
  30. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular and Molecular Biology
  31. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular and Molecular Biology
  32. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular and Molecular Biology
  33. 2022, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science

Research Activities

Academic Papers

  1. Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines, ONCOLOGY, 70(6), 458-464, 2006
  2. Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development, CANCER SCIENCE, 101(7), 1678-1685, 201007
  3. Increased telomerase activity and hTERT expression in human salivary gland carcinomas, ONCOLOGY LETTERS, 2(5), 845-850, 2011
  4. Two unrelated patients with MRE1 1A mutations and Nijmegen breakage syndrome-like severe microcephaly, DNA REPAIR, 10(3), 314-321, 20110307
  5. miR-22 represses cancer progression by inducing cellular senescence, JOURNAL OF CELL BIOLOGY, 193(2), 409-424, 20110418
  6. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair, NATURE GENETICS, 44(5), 593-+, 201205
  7. Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential, BMC MUSCULOSKELETAL DISORDERS, 13, 20120402
  8. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(46), 38716-38728, 20121109
  9. The role of exosomes and microRNAs in senescence and aging, ADVANCED DRUG DELIVERY REVIEWS, 65(3), 368-375, 201303
  10. Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1, CELL REPORTS, 3(5), 1651-1662, 201305
  11. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology, Pathol. Int., 49, 763-774, 19990401
  12. DNA-DNA Subtractive cDNA cloning using Oigo (dt)(30) -Latex and PCR-identification of cellular genes which are overexpressed in senescent human diploid fibroblasts., Anal Biochem, 214, 58-64, 19930401
  13. Preparation of subtractive cDNA library enriches in cDNAs which expressed at high level in cultured senescent human fibroblasts, Biochem. Biophys. Res. Commun., 199, 1108-1112, 19940401
  14. Telomerase activity in human liver tissues : Comparison between chronic liver disease and hepato cellular carcinoma., Cancer Research, 55, 2734-2736, 19950401
  15. Increase in expression level of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan, Oncogene, 10, 1125-1132, 19950401
  16. Inhibitors of cGMP-dependent protein kinase block seescence induced by inactivation of T antigen in SV40-fransformed immortal human fibroblasts, Oncogene, 11, 627-634, 19950401
  17. Telomerase activity in preneoplastic and neoplastic gastric and colovectal lesions, Clinical Cancer Research, 1, 1245-1251, 19950401
  18. Telomerase, 23, 247-256, 19960401
  19. A hVti1 homologue : Its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts., Biochem. Biophys. Res. Commun., 247, 70-74, 19980401
  20. Telomerase activation by the catalytic component gene TRT in human primary fibroblasts and hepatocellular carcinomas., Nature genetics, 18, 65-68, 19980401
  21. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity., Int J Oncol, 11, 139-143, 19970401
  22. Immortakization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity., Differentiation, 62, 203-211, 19970401
  23. Telomerase activity in ovarian tumors., Cancer, 80, 1085-1092, 19970401
  24. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinomas., Int J Cancer, 74, 141-147, 19970401
  25. Loss of amplified telomeric sequences associated with senescence in telomerasenegative SUSM-1 cells by introduction of human chromosome 7., Exp Cell Res, 235, 345-353, 19970401
  26. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay(HPA)connected with telomeric repeat amplification protocol(TRAP)., J. Cancer Res. Oncol., 123, 337-344, 19970401
  27. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinogenesis, Jpn.J.Cancer Res., 1187-1194, 19980401
  28. Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation., Surg. Neural, 267-274, 20000401
  29. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker., J Neurosurg, 618-625, 20000401
  30. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis, Cancer Letters, 149, 125-134, 20000401
  31. Inhibition of membrane Ca2+ ATPase of Saccharomyces cerevisiae by mating pheromone a factor in vitro, J. Gen. Microbiol.=, 137, 1-4, 19920401
  32. Expression of telomerase component genes in hepatocellular carcinomas., Eur. J. Cancer, 36, 496-502, 20000401
  33. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues., Oncogene, 19, 3888-3893, 20000401
  34. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker., J Neurosurg, 93, 618-625, 20000401
  35. Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity., J. Neurooncol., 47, 39-46, 20000401
  36. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections., Oncogene, 18, 1561-1567, 19990401
  37. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach., Jpn.J.Cancer Res., 90, 589-595, 19990401
  38. Telomerase activity in central nervous system malignant lymphoma., Cancer, 86, 1050-1055, 19990401
  39. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality., Mech. Ageing Dev., 110, 175-193, 19990401
  40. Quantitative re-evaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues., Mol. Carcinog., 26, 312-320, 19990401
  41. Telomerase activation by the catalytic component gene TRT in human primary fibroblasts and hepatocelluar carcinomas., Nature Genet., 18, 65-68, 19980401
  42. Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines., Biochem. Biophys. Res. Commun., 247, 765-772, 19980401
  43. A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts., Biochem. Biophys. Res. Commun., 247, 70-74, 19980401
  44. A new method to detect and measure telomerase activity by transcription-mediated amplification (TMA) and hybridization protection assay (HPA)., Clinical Chem., 44, 2446-2452, 19980401
  45. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions., Jpn.J.Cancer Res., 89, 1099-1103, 19980401
  46. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas., Jpn.J.Cancer Res., 89, 1187-1194, 19980401
  47. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity., Int J Oncol, 11, 139-143, 19970401
  48. Telomerase activity in ovarian tumors., Cancer, 80, 1085-1092, 19970401
  49. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinomas., Int J Cancer, 74, 141-147, 19970401
  50. Loss of amplified telomeric sequences associated with senescence in telomerase-negative SUSM-1 cells by introduction of human chromosome 7., Exp Cell Res, 235, 345-353, 19970401
  51. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay (HPA) connected with telomeric repeat amplification protocol (TRAP)., J Cancer Res Clin Oncol, 123, 337-344, 19970401
  52. Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity., Diffrentiation, 52, 203-211, 19970401
  53. Telomerase in hepatocellular carcinogenesis., Human Cell, 9, 283-286, 19960401
  54. Telomerase activity in normal human epithelial cells., Oncogene, 13, 433-439, 19960401
  55. Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens, including fine needle aspirates., Int J Cancer, 69, 301-306, 19960401
  56. Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas., Cancer Res., 55, 2734-2736, 19950401
  57. Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts., Oncogene, 10, 835-840, 19950401
  58. Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan., Oncogene, 11, 1125-1132, 19950401
  59. Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts., Oncogene, 11, 627-634, 19950401
  60. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3., Jpn.J.Cancer Res., 86, 899-904, 19950401
  61. Telomerase activity in precancerous and cancerous lesions of gastric and colorectal tissues., Clinical Cancer Res., 1, 1245-1251, 19950401
  62. Preparation of a substractive cDNA library enriched in cDNAs which expressed at a high level in cultured senescent human fibroblasts., Biochem. Biophys. Res. Commun., 199, 1108-1112, 19940401
  63. DNA-DNA subtractive cDNA cloning using oligo(dT)30-latex and PCR: Identification of cellular genes which are overexpressed in senescent human diploid fibroblasts., Anal Biochem, 214, 58-64, 19930401
  64. Telomerase activity in various precancerous and cancer tissues, The Proceedings of 87th Annual Meeting of the American Association for Cancer Reserch, 19960401
  65. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 20010401
  66. Distinct pattern of p53 phosphorylation in human tumors, Oncogene, 20(26), 3341-3347, 20010401
  67. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis, Cancer Letters, 149(2001/01/02), 125-134, 20000401
  68. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker, Journal of Neurosurgery, 93(4), 618-625, 20000401
  69. Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity, Journal of Neuro-Oncology, 47(1), 39-46, 20000401
  70. Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation, Surgical Neurology, 53(3), 267-274, 20000401
  71. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues, Oncogene, 19(34), 3888-3893, 20000401
  72. Immortalization of mammary cells from estrogen receptor alpha knock-out and wild-type mice, In Vitro Cellular of Developmental Biology, 36(10), 620-624, 20000401
  73. Expression of telomerase component genes in hepatocellular carcinomas, European Journal of Cancer, 36(4), 496-502, 20000401
  74. Cloning of a human hepatocyte growth factor/scatter factor transcription variant from a gastric cancer cell line HSC-39, INTERNATIONAL JOURNAL OF ONCOLOGY, 16(1), 105-108, 20000401
  75. Telomerase activity in central nervous system malignant lymphoma, Cancer, 86(6), 1050-1055, 19990401
  76. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality, Mechanisms of Ageing and Development, 110(3), 175-193, 19990401
  77. Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines, Biochemical and Biophysical Research Communications, 255(3), 753-758, 19990401
  78. Quantitative reevaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues, Molecular Carcinogenesis, 26(4), 312-320, 19990401
  79. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections, Oncogene, 18(8), 1561-1567, 19990401
  80. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology, Pathology International, 49(9), 763-774, 19990401
  81. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach, Japanese Journal of Cancer Research, 90(6), 589-595, 19990401
  82. Telomerase activity in lesions of the thyroid: Application to diagnosis of clinical samples including fine-needle aspirates, Clinical Cancer Research, 4(8), 1965-1970, 19980401
  83. New method to measure telomerase activity by transcription-mediated amplification and hybridization protection assay, Clinical Chemistry, 44(12), 2446-2452, 19980401
  84. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions, Japanese Journal of Cancer Research, 89(11), 1187-1194, 19980401
  85. A hVti1 homologue: Its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts, Biochemical and Biophysical Research Communications, 247(1), 70-74, 19980401
  86. Diagnostic value of telomerase activity in gynecologic malignancies, International Journal of Gynecological Cancer, 8(6), 481-488, 19980401
  87. ★, Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas, Nature genetics, 18(1), 65-68, 19980401
  88. A quantitative method to measure telomerase activity by hybridization protectin assay (HPA) connected with TRAP for the diagnosis of hepatocellular carcinoma (HCC)., Gastroenterology, 114(4), A1351-A1351, 19980401
  89. Extra-chromosome telomere repeat DNA in telomerase-negative immortalized cell lines, Biochemical and Biophysical Research Communications, 247(3), 765-772, 19980401
  90. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas, Japanese Journal of Cancer Research, 89(11), 1099-1103, 19980401
  91. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay connected with a telomeric repeat amplification protocol, Journal of Cancer Research and Clinical Oncology, 123(6), 337-344, 19970401
  92. Telomerase activity in premalignant and malignant lesions of human oral mucosal, 6(6), 413-420, 19970401
  93. Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity, Differentiation, 62(4), 203-211, 19970401
  94. Expression of human telomerase RNA is an early event of stomach carcinogenesis, Japanese Journal of Cancer Research, 88(2), 103-107, 19970401
  95. Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27(Kip1) in a human gastric carcinoma cell line, 8(1), 47-52, 19970401
  96. Telomerase activity in ovarian tumors, Cancer, 80(6), 1085-1092, 19970401
  97. Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1, Experimental Cell Research, 235(2), 345-353, 19970401
  98. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity, INTERNATIONAL JOURNAL OF ONCOLOGY, 11(1), 139-143, 19970401
  99. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma, International journal of cancer, 74(2), 141-147, 19970401
  100. Modified trap assay for the diagnosis of small differentiated hepatocellular carcinoma (HCC)., Gastroenterology, 112(4), A1344-A1344, 19970401
  101. Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine, Cancer, 79(2), 362-369, 19970401
  102. Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells, Jpn.J.Cancer Res., 87(4), 377-384, 19960401
  103. Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines, Jpn.J.Cancer Res., 87(8), 824-830, 19960401
  104. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence, Mol. Cell. Biol., 16(3), 859-867, 19960401
  105. Telomerase in hepatocellular carcinogenesis, Hum Cell, 9(4), 283-286, 19960401
  106. Telomerase activity in human breast cancer and benign breast lesions: diagnostic applications in clinical specimens, including fine needle aspirates, Int J Cancer, 69(4), 301-306, 19960401
  107. Molecular biological observations in gastric cancer, Semin Oncol, 23(3), 307-315, 19960401
  108. Telomerase activity in normal human epithelial cells, Oncogene, 13(2), 433-439, 19960401
  109. Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts, Oncogene, 11(4), 627-634, 19950401
  110. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3, Jpn.J.Cancer Res., 86(10), 899-904, 19950401
  111. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions, Clin. Cancer Res., 1(11), 1245-1251, 19950401
  112. Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan, Oncogene, 11(6), 1125-1132, 19950401
  113. ★, Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas, Cancer Res., 55(13), 2734-2736, 19950401
  114. ★, Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts, Oncogene, 10(5), 835-840, 19950401
  115. Preparation of a subtractive cDNA library enriched in cDNAs which expressed at a high level in cultured senescent human fibroblasts, Biochem. Biophys. Res. Commun., 199(3), 1108-1112, 19940401
  116. DNA-DNA subtractive cDNA cloning using oligo(dT)30-Latex and PCR: identification of cellular genes which are overexpressed in senescent human diploid fibroblasts, Anal Biochem, 214(1), 58-64, 19930401
  117. Genetic Status and Expression of the Cyclin-dependent Kinase Inhibitors in Human Gastric Carcinoma cell Lines, Jpn.J.Cancer Res., 87, 824-830, 19960101
  118. Expression of CDK inhibitor p21 and CDK2 in human colorectal carcinoma cell lines: relation with p53 status, Recent Advances in Gastroenterological Carcinogenesis., 749-753
  119. Involvement of telomere shortening and telomerase in cell aging and immortalization (M. Goto Ed.),, 147-163, 20010401
  120. Telomere and telomerase in Gastrointestinal cancers, 245-259., 19970401
  121. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas., Pathobiology, 69, 219-224, 20010401
  122. Expression and distribution of human telomerqase catalytic component, hTERT, in human breast tissues., Anticancer Research, 22, 4101-4108, 20020401
  123. In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformd by Epstein-Barr virus., DNA and Cell Biology, 20030401
  124. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus., Cancer Research, 64, 3361-3364, 20040401
  125. WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus. Cancer Genet., Cytogenet., 152, 95-100, 20040401
  126. Establishment of lifespan-extended human astrocytes with normal phenotypes by introduction of telomerase gene., Tissue Cult. Res. Commun., 23, 59-69, 20040401
  127. Telomeres and telomerase in hepatocellular carcinoma., Recent Res. Devel. Cancer, 6, 191-210, 20040401
  128. Terminal telomere repeats are actually short in telomerase-negative immortal human cells., Biol. Pharm. Bull., 27, 1932-1938, 20040401
  129. G1P3, An interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial mediated apoptosis in gastric cancer cell line TMK-1., Cancer Immunol. Immunoth., 54(8), 729-740, 20050401
  130. Establishment of cementoblast cell lines from rat cementum lining cells by transfection with temperature-sensitive simian virus-40 T-antigen gene., BONE, 37, 220-226, 20050401
  131. Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation., Stem Cells Dev, 15(6), 921-929, 20061201
  132. Immortalization and characterization of human dental pulp cells with odontoblastic differentiation., Archives of Oral Biology, 52(8), 727-731, 20070801
  133. Characterization of established cementoblast-like cell lines from human cementum lining cells in vitro and in vivo., Bone, 39(5), 1035-1042, 20061101
  134. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells., Biochemical and biophysical research communications, 926-932, 20070223
  135. Terminal telomere repeats are actually short in telomerase-negative immortal human cells., Biological & Pharmaceutical Bulletin, 27, 1932-1938, 20041201
  136. ★, G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells., Oncogene, 25(13), 1955-1966, 20060323
  137. Establishment of immortalized clonal cells derived from periodontal ligament cells by induction of the hTERT gene., Journal of Oral Science, 47(4), 177-184, 20051201
  138. ★, G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs, Nature Methods, 2(11), 829-831, 20051101
  139. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres., Cell, 126(1), 49-62, 20060714
  140. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination., European Molecular Biology Organization, 25(21), 5180-5190, 20061101
  141. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence., Nature Cell Biology, 8(11), 1291-1297, 20061101
  142. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome., American Journal of Medical Genetics, 140(4), 358-367, 20060215
  143. Quantitative proteomic analysis of human breast epithelial cells with differential telomere length, BBRC, 356(4), 942-947, 20070318
  144. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells., BBRC, 353(4), 926-932, 20070223
  145. Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene., International Journal Of Oncology, 31(2), 339-344, 20070801
  146. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3., Biochem. Biophys. Res. Commun., 337(1), 201-208, 20051111
  147. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly., DNA Repair (Amst), 20110301
  148. Telomere G-Overhang Length Measurement Method 2: G-Tail Telomere HPA, Methods in Molecular Biology, 735, 55-61, 20110301
  149. Introduction of a Single Transporter Gene ABCA3 Directs RLE–6TN to More Type II–like Alveolar Epithelial Cells, MEMBRANE, 38(5), 246-253, 20130801
  150. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker, JOURNAL OF NEUROSURGERY, 93(4), 618-625, 200010
  151. Distinct pattern of p53 phosphorylation in human tumors, ONCOGENE, 20(26), 3341-3347, 20010607
  152. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 200109
  153. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas, PATHOBIOLOGY, 69(4), 219-224, 2001
  154. Association of p16(INK4a) and pRb inactivation with immortalization of human cells, CARCINOGENESIS, 23(12), 2111-2117, 200212
  155. Expression and distribution of human telomerase catalytic component, hTERT, in human breast tissues, ANTICANCER RESEARCH, 22(6C), 4101-4107, 2002
  156. In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, DNA AND CELL BIOLOGY, 22(11), 727-735, 200311
  157. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, CANCER RESEARCH, 64(10), 3361-3364, 20040515
  158. WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, CANCER GENETICS AND CYTOGENETICS, 152(2), 95-100, 20040715
  159. Terminal telomere repeats are actually short in telomerase-negative immortal human cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 27(12), 1932-1938, 200412
  160. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell, CANCER IMMUNOLOGY IMMUNOTHERAPY, 54(8), 729-740, 200508
  161. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 337(1), 201-208, 20051111
  162. G-taff teLomere HPA: simple measurement of human single-stranded telomeric overhangs, NATURE METHODS, 2(11), 829-831, 200511
  163. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 140A(4), 358-367, 20060215
  164. G-quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3 ' telomeric overhang in cancer cells, ONCOGENE, 25(13), 1955-1966, 20060323
  165. Telomere and telomerase in age related diseases, SEIKAGAKU, 78(3), 230-241, 200603
  166. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres, CELL, 126(1), 49-62, 20060714
  167. Mitogenic signalling and the p16(INK4a)-Rb pathway cooperate to enforce irreversible cellular senescence, NATURE CELL BIOLOGY, 8(11), 1291-U63, 200611
  168. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 353(4), 926-932, 20070223
  169. Characterization of established cementoblast-like cell lines from human cementum-lining cells in vitro and in vivo, BONE, 39(5), 1035-1042, 200611
  170. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination, EMBO JOURNAL, 25(21), 5180-5190, 20061101
  171. Quantitative proteomic analysis of human breast epithelial cells with differential telomere length, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 356(4), 942-947, 20070518
  172. Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation, EXPERIMENTAL CELL RESEARCH, 314(5), 1115-1124, 20080310
  173. Role of menin in the regulation of telomerase activity in normal and cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(2), 333-340, 200808
  174. A Chiral Wedge Molecule Inhibits Telomerase Activity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(11), 3778-3782, 20100324
  175. Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops, AGING-US, 2(5), 274-284, 201005
  176. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 20101022
  177. MicroRNAs in Cancer: The 22nd Hiroshima Cancer Seminar/The 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 43(5), 579-582, 201305
  178. Generation of Human Induced Pluripotent Stem (Ips) Cells in Serum- and Feeder-Free Defined Culture and TGF-B1 Regulation of Pluripotency, PLOS ONE, 9(1), 20140129
  179. CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break-Specific G(2) Checkpoint, CANCER RESEARCH, 74(14), 3880-3889, 20140715
  180. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, 20140502
  181. DSE-FRET: A new anticancer drug screening assay for DNA binding proteins, CANCER SCIENCE, 105(7), 870-874, 201407
  182. Decreased Amyloid-beta Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(35), 24488-24498, 20140829
  183. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice, PLOS ONE, 9(10), 20141021
  184. A potential function for neuronal exosomes: Sequestering intracerebral amyloid-beta peptide, FEBS LETTERS, 589(1), 84-88, 20150102
  185. EVpedia: a community web portal for extracellular vesicles research, BIOINFORMATICS, 31(6), 933-939, 20150515
  186. Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture, PLOS ONE, 9(11), 20141112
  187. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 201408
  188. Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia, AMERICAN JOURNAL OF HUMAN GENETICS, 96(6), 1001-1007, 20150604
  189. Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study, EBIOMEDICINE, 2(8), 960-967, 201508
  190. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer, ONCOTARGET, 7(7), 8223-8239, 20160216
  191. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, 20160826
  192. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper, JOURNAL OF EXTRACELLULAR VESICLES, 6, 2017
  193. Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming, FRONTIERS IN GENETICS, 6, 20150129
  194. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles, STEM CELLS TRANSLATIONAL MEDICINE, 6(8), 201708
  195. Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations, STEM CELLS, 36(3), 434-445, 201803
  196. Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 498(4), 817-823, 20180415
  197. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40(6), 915-922, 201806
  198. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017, JOURNAL OF EXTRACELLULAR VESICLES, 7(1), 20180517
  199. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement, SCIENTIFIC REPORTS, 8, 20181001
  200. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells, SCIENTIFIC REPORTS, 8, 20181004

Invited Lecture, Oral Presentation, Poster Presentation

  1. Non-clinical study of locally administered microRNA nucleic acid medicine for malignant pleural mesothelioma, Hidetoshi Tahara, 2019/08/29, With Invitation, Japanese
  2. Circulating small RNAs in the serum as novel biomarkers for breast cancer detection, Yumiko Koi,Yasuhiro Tsutani, Yukie Nishiyama, Shinsuke Sasada, Tomoyuki Akita, NorioMasumoto, Takayuki Kadoya, Ryou-u Takahashi, Junko Tanaka, Morihito Okada, Hidetoshi Tahara, 2019/08/29, Without Invitation, Japanese
  3. Identification of PRPF19 as a novel target gene of senescence-associated microRNA; miR-27b-3p, Kimiyoshi Yano, Shisei Kan, Hiroki Sakagami, Ryou-u Takahashi and Hidetoshi Tahara, 2019/08/29, Without Invitation, Japanese
  4. The development of a novel nucleic acid drug against malignant pleural mesothelioma, Ayaka Nishiura, Yuki Yamamoto, Kimiyoshi Yano, Saori Fukunaga, Issei Shibuya, Ryou-u,Takahashi, Hidetoshi Tahara, 2019/08/28, Without Invitation, Japanese
  5. Senescent cells-derived extracellular vesicles repress tumour growth by transferring miR-127-3p and miR-134-5p., Megumi Okada,Kimiyoshi Yano,Shigeyuki Teranishi,Mariko Ikuo,Hidetoshi Tahara, ISEV2019, 2019/04/27, Without Invitation, English
  6. The factor affecting to the accuracy of extracellular small non-coding RNA biomarkers, Yukie Nishiyama,Yumiko Koi,Genki Nishimura, Eri Kojima,Morihito Okada,Hidetosi Tahara, ISEV2019, 2019/04/27, Without Invitation, English
  7. Isolation and characterization of bovine milk-derived Evs., Saori Fukunaga,Yuki Yamamoto,Hidetoshi Tahara, ISEV2019, 2019/04/26, Without Invitation, English
  8. BMP2 dependent osteoblast defferentiation is suppressed by multiplemyeloma-derived extracellular vesicles, Mariko Ikuo, ISEV2019, 2019/04/26, Without Invitation, English
  9. Characterization of extracellular vesicles (EVs) derived exRNA in cancer using NGS, Hidetoshi Tahara, qPCR dPCR & NGS 2019, 2019/03/18, With Invitation, English, Weihenstephan,Germany
  10. Telomere and microRNA in aging, 2018/10/10, With Invitation, Japanese
  11. MicroRNAs,isomiRs and tRFs are promising biomarkers as liquid biopsy for breast cancer detection., 2018/09/27, Without Invitation, Japanese
  12. A novel mechanism of p53-dependent cellular senescence by silencing of PRPF19, 2018/08/31, Without Invitation, Japanese
  13. Novel Senescence-Associated microRNA suppress malignant pleural mesothelioma, 2018/08/31, Without Invitation, Japanese
  14. A novel mechanism of p53-dependent cellular senescence by silencing of PRPF19, 2018/08/30, Without Invitation, Japanese
  15. Exploration of hemolysis-associated small non-coding RNA by Next Generation Sequence, 2018/08/30, Without Invitation, Japanese
  16. Novel Senescence-Associated microRNA suppress malignant pleural mesothelioma, 2018/08/29, Without Invitation, Japanese
  17. The relationship between human aging and advanced glycation end products of extracellular vesicles in serum., 2018/08/29, Without Invitation, Japanese
  18. Age-related expression change of circulating small non-coding RNAs, 2018/08/29, Without Invitation, Japanese
  19. Extracelluar vesicles derived from senescencet cells repress tumour growth via miRNAs, Mariko Ikuo,Megumi Okada, Shigeyuki Teranishi,Masaki Kinehara,Akira Shimamoto,Hidetoshi Tahara, ISEV2018, 2018/05/05, Without Invitation, English, Barcelona(Reino de España)
  20. Extracelluler small non-coding RNAs as promising biomarkers for early cancer detection, Yukie Nishiyama,Yumiko Koi,Genki Nishimura,Eri Kojima,Morihito Okada,Hidetoshi Tahara, ISEV2018, 2018/05/05, Without Invitation, English, Barcelona(Reino de España)
  21. Development of novel TRF2 inhibitor, Yoshitomo Shiroma,Go Fujita, Hidetoshi Tahara, EMBO Workshop, 2018/05/02, Without Invitation, English, Troia(Portugal)
  22. Application of exRNA and Circulating RNA for Early Detection of Cancer, Hidetoshi Tahara, Extracellular Vesicles as Biomarkers of Disease, 2017/12/13, Without Invitation, English
  23. Senescence cell - derived extracellular vesicles repress tumor growth, 2017/12/09, Without Invitation, Japanese
  24. Senescence cell - derived extracellular vesicles repress tumor growth, 2017/12/08, Without Invitation, Japanese
  25. Small non - coding RNA as biomarker promising early detection of pancreatic cancer, 2017/12/07, Without Invitation, Japanese
  26. Development of inhibitor of telomere binding protein using DSE-FRET assay, 2017/12/07, Without Invitation, Japanese
  27. Discovery and function analysis of RelA-DNA binding inhibitor using NF-kB DSE-FRET assay, 2017/12/07, Without Invitation, Japanese
  28. The association between glycation of sueface proteins on extracellular vesicles in serum and aging, 2017/12/06, Without Invitation, Japanese
  29. Senescence-associated microRNAs suppress malignant pleural mesothelioma cells, 2017/12/06, Without Invitation, Japanese
  30. Nucleic acid medicine based senescence-associated microRNAs for cancer therapy, 2017/12/06, Without Invitation, Japanese
  31. Mechanism of p53 activation via silenceing of PRPF19 in cellular senescence, 2017/12/06, Without Invitation, Japanese
  32. Validation of circulating microRNA using NGS, 2017/11/01, With Invitation, English
  33. "Cancer dormancy induced by Dox-inducible cancer stem cell model is maintained by BMP signaling", 2017/09/30, Without Invitation, Japanese
  34. "Novel senescence-associated microRNAs inhibit proliferation of intractable cancer cells", 2017/09/30, Without Invitation, Japanese
  35. The effect of TRF2 inhibitors in cancer cells, 2017/09/30, Without Invitation, Japanese
  36. PRPF19 is a novel potent molecular target for tumor suppression, 2017/09/30, Without Invitation, Japanese
  37. Senescence-associated microRNAs act as tumor suppressor hor both cancer stem cells and anti-cancer drug cancer cells, Hidetoshi Tahara, 2nd Global Insight Conference on Breast Cancer, 2017/09/05, Without Invitation, English, Rome
  38. Identification of serum preparation method that can get consistent circulating ncRNA profile., 2017/08/31, Without Invitation, Japanese
  39. Next-Generation Sequence analysis of exosomal small RNA isolated from cell culture media., 2017/08/30, Without Invitation, English
  40. miRNA in aging and cancer, 2017/08/28, With Invitation, English
  41. "An in vitro model for cancer stem cell dormancy and recurrence using tetinducible reprogramming system", 2017/07/01, With Invitation, Japanese
  42. Screening of senescence-inducible microRNAs for cancer therapy, 2017/07/01, Without Invitation, Japanese
  43. MicroRNA and exosome in Aging, Hidetoshi Tahara, 2017/06/15, With Invitation, English
  44. Extracellular RNA is promising biomarker for eary detection of cancers, Hidetoshi Tahara, Yukie Nishiyama,Yumiko Koui,Yuki Yamamoto,Genki Nishimura,Masaki Kinehara,Akira Shimamoto,Morito Okada,Hidetoshi Tahara, ISEV2017, 2017/05/19, Without Invitation, English, Toronto,Canada
  45. Circulating microRNAs as novel promising biomarkers for early detection of Tongue Cancer, Hidetoshi Tahara, ESMO ASIA, 2017/01/16, Without Invitation, Japanese, シンガポール
  46. Screening of senescence-associated microRNAs having anti- proliferative effect in human cancer cells, 2016/10/08, Without Invitation, Japanese
  47. Biogenesisandbiologicalactivitiesofexosomesderivedfrom replicative senescent fibroblast cells, 2016/10/08, Without Invitation, Japanese
  48. Application of senescence-inducible microRNAs for cancer therapy, 2016/10/06, With Invitation, Japanese
  49. Induction of cancer stem cell dormancy and recurrence by Dox-inducible secondary reprogramming system, 2016/10/06, Without Invitation, Japanese
  50. The potential for applying PRPF19 siRNA to anti-cancer therapeutics, 2016/09/14, Without Invitation, Japanese
  51. The potential for applying PRPF19 siRNA to anti-cancer therapeutics, 2016/09/01, Without Invitation, Japanese
  52. p16-dependent induction of cell death by senescence-inducible microRNA in pancreatic cancer cells., 2016/08/31, Without Invitation, Japanese
  53. Nucleic Acid Therapeutics targeting microRNAs, 2016/07/30, With Invitation, Japanese
  54. The Significant Function Of EVs In Aging And Cancer, Hidetoshi Tahara, Extracellular Vesicles 2016, 2016/07/12, Without Invitation, English, Cambridge, UK
  55. Apoptotic Effect of Senescence-inducible microRNAs on Human Cancer Cell Lines, Masaki Kinehara,Yuki Yamamoto,Saori Fukunaga,Akira Shimamoto,Hidetoshi Tahara, 2016/06/24, Without Invitation, Japanese
  56. Inhibition of cancer cell growth by senescence-inducible miRNA, 2016/05/25, Without Invitation, Japanese
  57. "Non-coding RNAs Senescence-associated EVs from fibroblasts act as tumor suppressor at the tumor microenvironment.", Hidetoshi Tahara, 2016/02/18, Without Invitation, English, other
  58. Depletion of PRPF19 regulates cell fate between cellular senescence and cell death, 2015/12/03, Without Invitation, Japanese, other
  59. Histone variant H3.3 depletion induces cellular senescence in human diploid fibroblasts, 2015/12/02, Without Invitation, Japanese, other
  60. FunctionalanalysisofmiR-486inpancreaticcancer, 2015/10/10, Without Invitation, Japanese, other
  61. DepletionofPRPF19regulatescellfatebetweencellular senescence and cell death, 2015/10/10, Without Invitation, Japanese, other
  62. Thenovelmoleculartargetsforanti-cancerdrugtargeting transcription factors, 2015/10/10, Without Invitation, Japanese, other
  63. Identification of novel senescence-associated microRNAs in human fibroblasts, 2015/10/08, Without Invitation, Japanese, other
  64. Liquid Biopsy by using telomere and microRNA, JASIS2015, 2015/09/04, With Invitation, Japanese, other
  65. miR-486 has potential as nucleic acid medicine, 2015/08/27, Without Invitation, Japanese, published
  66. Senescence associated microRNA suppress cell proliferation in pancreatic cancer, 2015/08/27, Without Invitation, Japanese, published
  67. Understanding the mechanisms of the PRPF19 siRNA-mediated anti-tumor effect, 2015/08/27, Without Invitation, Japanese, published
  68. Cell-derived extracellular vesicle regulates cellular senescence, 2015/08/27, Without Invitation, Japanese, published
  69. The analysis of biological significance of extracellular vesicles in replicative senescence, 2015/08/27, Without Invitation, Japanese, published
  70. Role of phage display technology to proteomics, 2015/07/23, Without Invitation, Japanese, other
  71. Stable propagation of human pluripotent stem cells by dual inhibition of PKC and ERK signaling, 2015/05/26, Without Invitation, Japanese, other
  72. A large-scale membrane proteome analysis in scirrhous gastric cancer cell, 2015/05/26, Without Invitation, Japanese, other
  73. High-content screening of senescence-inducible microRNAs, 2015/05/26, Without Invitation, Japanese, other
  74. Analysis of senescence-associated miRNA that suppress pancreatic cancer, 2015/05/26, Without Invitation, Japanese, other
  75. Generation of Werner syndrome-specific iPS cells and challenges towards clinical application, 2015/05/26, Without Invitation, Japanese, other
  76. DNA Damage Response in Human Induced Pluripotent Stem Cells, Akira Shimamoto,Harunobu Kagawa,Hidehiko Kawai,Tetsushi Sakuma,Takashi Yamamoto,Bunsyo Shiotani,Hidetoshi Tahara, ICRR2015, 2015/05/25, Without Invitation, English, other
  77. Senescence-associated EVs act as tumor suppressors in the tumor microenvironment, Hidetoshi Tahara, International Soclety for Extracellular Vesicies 2015, 2015/04/25, Without Invitation, English, experimental

Social Activities

Organizing Academic Conferences, etc.

  1. 2012/08
  2. The 7th JARI Annual Meeting, 2015/08, 2015/08
  3. The 8th JARI Annual Meeting, 2016/08, 2016/08
  4. The 9th JARI Annual Meeting, 2017/08, 2017/09
  5. 2018/08, 2018/08