Hidetoshi Tahara

Last Updated :2022/05/09

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Pharmaceutical Sciences), Professor
E-mail
toshihiroshima-u.ac.jp
Self-introduction
My research fields are Telomere, microRNA and exosome in aging and cancer.

Basic Information

Major Professional Backgrounds

  • 2000/05/01, 2001/03/31
  • 1994/10/01, 2000/04/30
  • 2006/04/01
  • 2002/04/01, 2006/03/31
  • 2002/04/01, 2006/03/31
  • 2001/04/01, 2002/03/31

Educational Backgrounds

  • Hiroshima University, Graduate School, Division of Medical Sciences, Japan, 1991/04, 1994/03
  • Tokyo University of Pharmacy and Life Science, Faculty of Pharmaceutical Science, Japan, 1985/04, 1989/03

Academic Degrees

  • Doctor of Philosophy in Pharmaceutical Science, Hiroshima University
  • Master of Pharmaceutical Science, Hiroshima University

Educational Activity

  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Pharmaceutical Sciences : Pharmaceutical Sciences
  • [Bachelor Degree Program] School of Pharmaceutical Sciences : Program of Medicinal Sciences : Medicinal Sciences
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Medicinal Sciences
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Pharmaceutical Sciences

Research Fields

  • Biological Sciences;Oncology;Tumor biology
  • Biological Sciences;Oncology;Tumor diagnostics

Research Keywords

  • Telomerase
  • Immortalization
  • Telomere
  • Cellular senescence
  • microRNA
  • Exosome
  • Extracellular vesicles
  • Biomarker

Affiliated Academic Societies

  • Japanese Society of Extracellular Vesicles, 2014
  • American Assciation for Cancer Research
  • Japanese RNAi association, 2008

Educational Activity

Course in Charge

  1. 2022, Undergraduate Education, 3Term, Biochemistry V
  2. 2022, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences II
  3. 2022, Undergraduate Education, Second Semester, Special laboratory Works in Pharmaceutical Sciences III
  4. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy II
  5. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy III
  6. 2022, Graduate Education (Doctoral Program) , 1Term, Advanced Lecture on Methods in biomedical sciences
  7. 2022, Graduate Education (Doctoral Program) , 3Term, Advanced Lecture on Creation and Development of Biomedical Sciences
  8. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced seminar on Cellular and Molecular Biology
  9. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced seminar on Cellular and Molecular Biology
  10. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced research on Cellular and Molecular Biology
  11. 2022, Graduate Education (Doctoral Program) , 1Term, Methods in Biomedical Sciences B
  12. 2022, Undergraduate Education, 3Term, Introduction to Pharmaceutical Sciences
  13. 2022, Graduate Education (Master's Program) , 1Term, Seminar on Health Policy & Global Health
  14. 2022, Graduate Education (Master's Program) , 1Term, Methods in Biomedical Sciences A
  15. 2022, Graduate Education (Doctoral Program) , 3Term, Creation and Development of Biomedical Sciences
  16. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Cellular and Molecular Biology
  17. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Cellular and Molecular Biology
  18. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Cellular and Molecular Biology
  19. 2022, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Cellular and Molecular Biology
  20. 2022, Graduate Education (Master's Program) , First Semester, Lecture on Medicinal Science
  21. 2022, Graduate Education (Doctoral Program) , First Semester, Advanced Lecture on Medicinal Science
  22. 2022, Graduate Education (Master's Program) , First Semester, Seminar on Cell Regeneration
  23. 2022, Undergraduate Education, First Semester, Practice of xenobiotics and molecular toxicology
  24. 2022, Graduate Education (Master's Program) , Second Semester, Seminar on Cell Regeneration
  25. 2022, Graduate Education (Master's Program) , First Semester, Research on Cell Regeneration
  26. 2022, Graduate Education (Master's Program) , Second Semester, Research on Cell Regeneration
  27. 2022, Undergraduate Education, 4Term, Biochemistry VI
  28. 2022, Undergraduate Education, 4Term, Cell Biology
  29. 2022, Undergraduate Education, 3Term, Japanese Pharmacopoeia
  30. 2022, Undergraduate Education, Second Semester, Experiments of Cellular and Molecular Biology
  31. 2022, Undergraduate Education, Year, Special laboratory Works in Clinical Pharmacy I
  32. 2022, Undergraduate Education, Year, Special laboratory Works in Pharmaceutical Sciences I

Research Activities

Academic Papers

  1. The role of exosomes and microRNAs in senescence and aging, ADVANCED DRUG DELIVERY REVIEWS, 65(3), 368-375, 201303
  2. Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines, Biochemical and Biophysical Research Communications, 255(3), 753-758, 19990401
  3. Quantitative reevaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues, Molecular Carcinogenesis, 26(4), 312-320, 19990401
  4. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections, Oncogene, 18(8), 1561-1567, 19990401
  5. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology, Pathology International, 49(9), 763-774, 19990401
  6. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach, Japanese Journal of Cancer Research, 90(6), 589-595, 19990401
  7. Telomerase activity in lesions of the thyroid: Application to diagnosis of clinical samples including fine-needle aspirates, Clinical Cancer Research, 4(8), 1965-1970, 19980401
  8. New method to measure telomerase activity by transcription-mediated amplification and hybridization protection assay, Clinical Chemistry, 44(12), 2446-2452, 19980401
  9. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions, Japanese Journal of Cancer Research, 89(11), 1187-1194, 19980401
  10. A hVti1 homologue: Its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts, Biochemical and Biophysical Research Communications, 247(1), 70-74, 19980401
  11. Diagnostic value of telomerase activity in gynecologic malignancies, International Journal of Gynecological Cancer, 8(6), 481-488, 19980401
  12. Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1, CELL REPORTS, 3(5), 1651-1662, 201305
  13. ★, Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas, Nature genetics, 18(1), 65-68, 19980401
  14. A quantitative method to measure telomerase activity by hybridization protectin assay (HPA) connected with TRAP for the diagnosis of hepatocellular carcinoma (HCC)., Gastroenterology, 114(4), A1351-A1351, 19980401
  15. Extra-chromosome telomere repeat DNA in telomerase-negative immortalized cell lines, Biochemical and Biophysical Research Communications, 247(3), 765-772, 19980401
  16. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas, Japanese Journal of Cancer Research, 89(11), 1099-1103, 19980401
  17. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay connected with a telomeric repeat amplification protocol, Journal of Cancer Research and Clinical Oncology, 123(6), 337-344, 19970401
  18. Telomerase activity in premalignant and malignant lesions of human oral mucosal, 6(6), 413-420, 19970401
  19. Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity, Differentiation, 62(4), 203-211, 19970401
  20. Expression of human telomerase RNA is an early event of stomach carcinogenesis, Japanese Journal of Cancer Research, 88(2), 103-107, 19970401
  21. Growth inhibitory effect of interferon-beta is associated with the induction of cyclin-dependent kinase inhibitor p27(Kip1) in a human gastric carcinoma cell line, 8(1), 47-52, 19970401
  22. Telomerase activity in ovarian tumors, Cancer, 80(6), 1085-1092, 19970401
  23. Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1, Experimental Cell Research, 235(2), 345-353, 19970401
  24. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity, INTERNATIONAL JOURNAL OF ONCOLOGY, 11(1), 139-143, 19970401
  25. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinoma, International journal of cancer, 74(2), 141-147, 19970401
  26. Modified trap assay for the diagnosis of small differentiated hepatocellular carcinoma (HCC)., Gastroenterology, 112(4), A1344-A1344, 19970401
  27. Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine, Cancer, 79(2), 362-369, 19970401
  28. Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells, Jpn.J.Cancer Res., 87(4), 377-384, 19960401
  29. Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines, Jpn.J.Cancer Res., 87(8), 824-830, 19960401
  30. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence, Mol. Cell. Biol., 16(3), 859-867, 19960401
  31. Telomerase in hepatocellular carcinogenesis, Hum Cell, 9(4), 283-286, 19960401
  32. Telomerase activity in human breast cancer and benign breast lesions: diagnostic applications in clinical specimens, including fine needle aspirates, Int J Cancer, 69(4), 301-306, 19960401
  33. Molecular biological observations in gastric cancer, Semin Oncol, 23(3), 307-315, 19960401
  34. Telomerase activity in normal human epithelial cells, Oncogene, 13(2), 433-439, 19960401
  35. Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts, Oncogene, 11(4), 627-634, 19950401
  36. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3, Jpn.J.Cancer Res., 86(10), 899-904, 19950401
  37. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions, Clin. Cancer Res., 1(11), 1245-1251, 19950401
  38. Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan, Oncogene, 11(6), 1125-1132, 19950401
  39. ★, Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas, Cancer Res., 55(13), 2734-2736, 19950401
  40. ★, Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts, Oncogene, 10(5), 835-840, 19950401
  41. Preparation of a subtractive cDNA library enriched in cDNAs which expressed at a high level in cultured senescent human fibroblasts, Biochem. Biophys. Res. Commun., 199(3), 1108-1112, 19940401
  42. DNA-DNA subtractive cDNA cloning using oligo(dT)30-Latex and PCR: identification of cellular genes which are overexpressed in senescent human diploid fibroblasts, Anal Biochem, 214(1), 58-64, 19930401
  43. Genetic Status and Expression of the Cyclin-dependent Kinase Inhibitors in Human Gastric Carcinoma cell Lines, Jpn.J.Cancer Res., 87, 824-830, 19960101
  44. Expression of CDK inhibitor p21 and CDK2 in human colorectal carcinoma cell lines: relation with p53 status, Recent Advances in Gastroenterological Carcinogenesis., 749-753
  45. Involvement of telomere shortening and telomerase in cell aging and immortalization (M. Goto Ed.),, 147-163, 20010401
  46. Telomere and telomerase in Gastrointestinal cancers, 245-259., 19970401
  47. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas., Pathobiology, 69, 219-224, 20010401
  48. Expression and distribution of human telomerqase catalytic component, hTERT, in human breast tissues., Anticancer Research, 22, 4101-4108, 20020401
  49. In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformd by Epstein-Barr virus., DNA and Cell Biology, 20030401
  50. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus., Cancer Research, 64, 3361-3364, 20040401
  51. WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus. Cancer Genet., Cytogenet., 152, 95-100, 20040401
  52. Establishment of lifespan-extended human astrocytes with normal phenotypes by introduction of telomerase gene., Tissue Cult. Res. Commun., 23, 59-69, 20040401
  53. Telomeres and telomerase in hepatocellular carcinoma., Recent Res. Devel. Cancer, 6, 191-210, 20040401
  54. Terminal telomere repeats are actually short in telomerase-negative immortal human cells., Biol. Pharm. Bull., 27, 1932-1938, 20040401
  55. G1P3, An interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial mediated apoptosis in gastric cancer cell line TMK-1., Cancer Immunol. Immunoth., 54(8), 729-740, 20050401
  56. Establishment of cementoblast cell lines from rat cementum lining cells by transfection with temperature-sensitive simian virus-40 T-antigen gene., BONE, 37, 220-226, 20050401
  57. Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation., Stem Cells Dev, 15(6), 921-929, 20061201
  58. Immortalization and characterization of human dental pulp cells with odontoblastic differentiation., Archives of Oral Biology, 52(8), 727-731, 20070801
  59. Characterization of established cementoblast-like cell lines from human cementum lining cells in vitro and in vivo., Bone, 39(5), 1035-1042, 20061101
  60. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells., Biochemical and biophysical research communications, 926-932, 20070223
  61. Terminal telomere repeats are actually short in telomerase-negative immortal human cells., Biological & Pharmaceutical Bulletin, 27, 1932-1938, 20041201
  62. ★, G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells., Oncogene, 25(13), 1955-1966, 20060323
  63. Establishment of immortalized clonal cells derived from periodontal ligament cells by induction of the hTERT gene., Journal of Oral Science, 47(4), 177-184, 20051201
  64. ★, G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs, Nature Methods, 2(11), 829-831, 20051101
  65. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres., Cell, 126(1), 49-62, 20060714
  66. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination., European Molecular Biology Organization, 25(21), 5180-5190, 20061101
  67. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence., Nature Cell Biology, 8(11), 1291-1297, 20061101
  68. Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology, Pathol. Int., 49, 763-774, 19990401
  69. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome., American Journal of Medical Genetics, 140(4), 358-367, 20060215
  70. Quantitative proteomic analysis of human breast epithelial cells with differential telomere length, BBRC, 356(4), 942-947, 20070318
  71. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells., BBRC, 353(4), 926-932, 20070223
  72. Immortalization and characterization of pleomorphic adenoma cells by transfection with the hTERT gene., International Journal Of Oncology, 31(2), 339-344, 20070801
  73. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3., Biochem. Biophys. Res. Commun., 337(1), 201-208, 20051111
  74. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly., DNA Repair (Amst), 20110301
  75. Telomere G-Overhang Length Measurement Method 2: G-Tail Telomere HPA, Methods in Molecular Biology, 735, 55-61, 20110301
  76. Introduction of a Single Transporter Gene ABCA3 Directs RLE–6TN to More Type II–like Alveolar Epithelial Cells, MEMBRANE, 38(5), 246-253, 20130801
  77. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker, JOURNAL OF NEUROSURGERY, 93(4), 618-625, 200010
  78. Distinct pattern of p53 phosphorylation in human tumors, ONCOGENE, 20(26), 3341-3347, 20010607
  79. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 200109
  80. Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas, PATHOBIOLOGY, 69(4), 219-224, 2001
  81. Association of p16(INK4a) and pRb inactivation with immortalization of human cells, CARCINOGENESIS, 23(12), 2111-2117, 200212
  82. Expression and distribution of human telomerase catalytic component, hTERT, in human breast tissues, ANTICANCER RESEARCH, 22(6C), 4101-4107, 2002
  83. In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, DNA AND CELL BIOLOGY, 22(11), 727-735, 200311
  84. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, CANCER RESEARCH, 64(10), 3361-3364, 20040515
  85. WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus, CANCER GENETICS AND CYTOGENETICS, 152(2), 95-100, 20040715
  86. Terminal telomere repeats are actually short in telomerase-negative immortal human cells, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 27(12), 1932-1938, 200412
  87. G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell, CANCER IMMUNOLOGY IMMUNOTHERAPY, 54(8), 729-740, 200508
  88. IL-6-induced Bcl6 variant 2 supports IL-6-dependent myeloma cell proliferation and survival through STAT3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 337(1), 201-208, 20051111
  89. G-taff teLomere HPA: simple measurement of human single-stranded telomeric overhangs, NATURE METHODS, 2(11), 829-831, 200511
  90. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 140A(4), 358-367, 20060215
  91. G-quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3 ' telomeric overhang in cancer cells, ONCOGENE, 25(13), 1955-1966, 20060323
  92. Telomere and telomerase in age related diseases, SEIKAGAKU, 78(3), 230-241, 200603
  93. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres, CELL, 126(1), 49-62, 20060714
  94. Mitogenic signalling and the p16(INK4a)-Rb pathway cooperate to enforce irreversible cellular senescence, NATURE CELL BIOLOGY, 8(11), 1291-U63, 200611
  95. Telomerase activation induces elongation of the telomeric single-stranded overhang, but does not prevent chromosome aberrations in human vascular endothelial cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 353(4), 926-932, 20070223
  96. Characterization of established cementoblast-like cell lines from human cementum-lining cells in vitro and in vivo, BONE, 39(5), 1035-1042, 200611
  97. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination, EMBO JOURNAL, 25(21), 5180-5190, 20061101
  98. Quantitative proteomic analysis of human breast epithelial cells with differential telomere length, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 356(4), 942-947, 20070518
  99. Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines, ONCOLOGY, 70(6), 458-464, 2006
  100. DNA-DNA Subtractive cDNA cloning using Oigo (dt)(30) -Latex and PCR-identification of cellular genes which are overexpressed in senescent human diploid fibroblasts., Anal Biochem, 214, 58-64, 19930401
  101. Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation, EXPERIMENTAL CELL RESEARCH, 314(5), 1115-1124, 20080310
  102. Role of menin in the regulation of telomerase activity in normal and cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 33(2), 333-340, 200808
  103. A Chiral Wedge Molecule Inhibits Telomerase Activity, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(11), 3778-3782, 20100324
  104. Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops, AGING-US, 2(5), 274-284, 201005
  105. Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(43), 33018-33027, 20101022
  106. MicroRNAs in Cancer: The 22nd Hiroshima Cancer Seminar/The 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 43(5), 579-582, 201305
  107. Generation of Human Induced Pluripotent Stem (Ips) Cells in Serum- and Feeder-Free Defined Culture and TGF-B1 Regulation of Pluripotency, PLOS ONE, 9(1), 20140129
  108. CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break-Specific G(2) Checkpoint, CANCER RESEARCH, 74(14), 3880-3889, 20140715
  109. TERT attenuated ER stress-induced cell death, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 447(2), 378-382, 20140502
  110. DSE-FRET: A new anticancer drug screening assay for DNA binding proteins, CANCER SCIENCE, 105(7), 870-874, 201407
  111. Preparation of subtractive cDNA library enriches in cDNAs which expressed at high level in cultured senescent human fibroblasts, Biochem. Biophys. Res. Commun., 199, 1108-1112, 19940401
  112. Decreased Amyloid-beta Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice, JOURNAL OF BIOLOGICAL CHEMISTRY, 289(35), 24488-24498, 20140829
  113. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice, PLOS ONE, 9(10), 20141021
  114. A potential function for neuronal exosomes: Sequestering intracerebral amyloid-beta peptide, FEBS LETTERS, 589(1), 84-88, 20150102
  115. EVpedia: a community web portal for extracellular vesicles research, BIOINFORMATICS, 31(6), 933-939, 20150515
  116. Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture, PLOS ONE, 9(11), 20141112
  117. Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients, CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 9(12), 2117-2122, 201408
  118. Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia, AMERICAN JOURNAL OF HUMAN GENETICS, 96(6), 1001-1007, 20150604
  119. Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study, EBIOMEDICINE, 2(8), 960-967, 201508
  120. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer, ONCOTARGET, 7(7), 8223-8239, 20160216
  121. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death, NEUROSCIENCE LETTERS, 629, 241-244, 20160826
  122. Telomerase activity in human liver tissues : Comparison between chronic liver disease and hepato cellular carcinoma., Cancer Research, 55, 2734-2736, 19950401
  123. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper, JOURNAL OF EXTRACELLULAR VESICLES, 6, 2017
  124. Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming, FRONTIERS IN GENETICS, 6, 20150129
  125. Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles, STEM CELLS TRANSLATIONAL MEDICINE, 6(8), 201708
  126. Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations, STEM CELLS, 36(3), 434-445, 201803
  127. Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 498(4), 817-823, 20180415
  128. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses, BIOTECHNOLOGY LETTERS, 40(6), 915-922, 201806
  129. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017, JOURNAL OF EXTRACELLULAR VESICLES, 7(1), 20180517
  130. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement, SCIENTIFIC REPORTS, 8, 20181001
  131. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells, SCIENTIFIC REPORTS, 8, 20181004
  132. Increase in expression level of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan, Oncogene, 10, 1125-1132, 19950401
  133. Inhibitors of cGMP-dependent protein kinase block seescence induced by inactivation of T antigen in SV40-fransformed immortal human fibroblasts, Oncogene, 11, 627-634, 19950401
  134. Telomerase activity in preneoplastic and neoplastic gastric and colovectal lesions, Clinical Cancer Research, 1, 1245-1251, 19950401
  135. Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development, CANCER SCIENCE, 101(7), 1678-1685, 201007
  136. Telomerase, 23, 247-256, 19960401
  137. A hVti1 homologue : Its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts., Biochem. Biophys. Res. Commun., 247, 70-74, 19980401
  138. Telomerase activation by the catalytic component gene TRT in human primary fibroblasts and hepatocellular carcinomas., Nature genetics, 18, 65-68, 19980401
  139. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity., Int J Oncol, 11, 139-143, 19970401
  140. Immortakization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity., Differentiation, 62, 203-211, 19970401
  141. Telomerase activity in ovarian tumors., Cancer, 80, 1085-1092, 19970401
  142. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinomas., Int J Cancer, 74, 141-147, 19970401
  143. Loss of amplified telomeric sequences associated with senescence in telomerasenegative SUSM-1 cells by introduction of human chromosome 7., Exp Cell Res, 235, 345-353, 19970401
  144. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay(HPA)connected with telomeric repeat amplification protocol(TRAP)., J. Cancer Res. Oncol., 123, 337-344, 19970401
  145. Increased telomerase activity and hTERT expression in human salivary gland carcinomas, ONCOLOGY LETTERS, 2(5), 845-850, 2011
  146. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinogenesis, Jpn.J.Cancer Res., 1187-1194, 19980401
  147. Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation., Surg. Neural, 267-274, 20000401
  148. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker., J Neurosurg, 618-625, 20000401
  149. Two unrelated patients with MRE1 1A mutations and Nijmegen breakage syndrome-like severe microcephaly, DNA REPAIR, 10(3), 314-321, 20110307
  150. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis, Cancer Letters, 149, 125-134, 20000401
  151. Inhibition of membrane Ca2+ ATPase of Saccharomyces cerevisiae by mating pheromone a factor in vitro, J. Gen. Microbiol.=, 137, 1-4, 19920401
  152. Expression of telomerase component genes in hepatocellular carcinomas., Eur. J. Cancer, 36, 496-502, 20000401
  153. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues., Oncogene, 19, 3888-3893, 20000401
  154. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker., J Neurosurg, 93, 618-625, 20000401
  155. Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity., J. Neurooncol., 47, 39-46, 20000401
  156. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections., Oncogene, 18, 1561-1567, 19990401
  157. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the stomach., Jpn.J.Cancer Res., 90, 589-595, 19990401
  158. Telomerase activity in central nervous system malignant lymphoma., Cancer, 86, 1050-1055, 19990401
  159. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality., Mech. Ageing Dev., 110, 175-193, 19990401
  160. miR-22 represses cancer progression by inducing cellular senescence, JOURNAL OF CELL BIOLOGY, 193(2), 409-424, 20110418
  161. Quantitative re-evaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues., Mol. Carcinog., 26, 312-320, 19990401
  162. Telomerase activation by the catalytic component gene TRT in human primary fibroblasts and hepatocelluar carcinomas., Nature Genet., 18, 65-68, 19980401
  163. Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines., Biochem. Biophys. Res. Commun., 247, 765-772, 19980401
  164. A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts., Biochem. Biophys. Res. Commun., 247, 70-74, 19980401
  165. A new method to detect and measure telomerase activity by transcription-mediated amplification (TMA) and hybridization protection assay (HPA)., Clinical Chem., 44, 2446-2452, 19980401
  166. In situ mRNA hybridization technique for analysis of human telomerase RNA in gastric precancerous and cancerous lesions., Jpn.J.Cancer Res., 89, 1099-1103, 19980401
  167. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas., Jpn.J.Cancer Res., 89, 1187-1194, 19980401
  168. Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity., Int J Oncol, 11, 139-143, 19970401
  169. Telomerase activity in ovarian tumors., Cancer, 80, 1085-1092, 19970401
  170. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair, NATURE GENETICS, 44(5), 593-+, 201205
  171. Significance of telomerase activity in the diagnosis of small differentiated hepatocellular carcinomas., Int J Cancer, 74, 141-147, 19970401
  172. Loss of amplified telomeric sequences associated with senescence in telomerase-negative SUSM-1 cells by introduction of human chromosome 7., Exp Cell Res, 235, 345-353, 19970401
  173. A rapid, useful and quantitative method to measure telomerase activity by hybridization protection assay (HPA) connected with telomeric repeat amplification protocol (TRAP)., J Cancer Res Clin Oncol, 123, 337-344, 19970401
  174. Immortalization of immunologically committed Epstein-Barr virus-transformed human B-lymphoblastoid cell lines accompanied by a strong telomerase activity., Diffrentiation, 52, 203-211, 19970401
  175. Telomerase in hepatocellular carcinogenesis., Human Cell, 9, 283-286, 19960401
  176. Telomerase activity in normal human epithelial cells., Oncogene, 13, 433-439, 19960401
  177. Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens, including fine needle aspirates., Int J Cancer, 69, 301-306, 19960401
  178. Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas., Cancer Res., 55, 2734-2736, 19950401
  179. Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts., Oncogene, 10, 835-840, 19950401
  180. Increase in expression levels of interferon-inducible genes in senescent human diploid fibroblasts and in SV40-transformed human fibroblasts with extended lifespan., Oncogene, 11, 1125-1132, 19950401
  181. Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential, BMC MUSCULOSKELETAL DISORDERS, 13, 20120402
  182. Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts., Oncogene, 11, 627-634, 19950401
  183. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3., Jpn.J.Cancer Res., 86, 899-904, 19950401
  184. Telomerase activity in precancerous and cancerous lesions of gastric and colorectal tissues., Clinical Cancer Res., 1, 1245-1251, 19950401
  185. Preparation of a substractive cDNA library enriched in cDNAs which expressed at a high level in cultured senescent human fibroblasts., Biochem. Biophys. Res. Commun., 199, 1108-1112, 19940401
  186. DNA-DNA subtractive cDNA cloning using oligo(dT)30-latex and PCR: Identification of cellular genes which are overexpressed in senescent human diploid fibroblasts., Anal Biochem, 214, 58-64, 19930401
  187. Telomerase activity in various precancerous and cancer tissues, The Proceedings of 87th Annual Meeting of the American Association for Cancer Reserch, 19960401
  188. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas, INTERNATIONAL JOURNAL OF ONCOLOGY, 19(3), 507-512, 20010401
  189. Distinct pattern of p53 phosphorylation in human tumors, Oncogene, 20(26), 3341-3347, 20010401
  190. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(46), 38716-38728, 20121109
  191. DNA hypermethylation at the pS2 promoter region is associated with early stage of stomach carcinogenesis, Cancer Letters, 149(2001/01/02), 125-134, 20000401
  192. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker, Journal of Neurosurgery, 93(4), 618-625, 20000401
  193. Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity, Journal of Neuro-Oncology, 47(1), 39-46, 20000401
  194. Telomerase activity and the expression of telomerase components in pituitary adenoma with malignant transformation, Surgical Neurology, 53(3), 267-274, 20000401
  195. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues, Oncogene, 19(34), 3888-3893, 20000401
  196. Immortalization of mammary cells from estrogen receptor alpha knock-out and wild-type mice, In Vitro Cellular of Developmental Biology, 36(10), 620-624, 20000401
  197. Expression of telomerase component genes in hepatocellular carcinomas, European Journal of Cancer, 36(4), 496-502, 20000401
  198. Cloning of a human hepatocyte growth factor/scatter factor transcription variant from a gastric cancer cell line HSC-39, INTERNATIONAL JOURNAL OF ONCOLOGY, 16(1), 105-108, 20000401
  199. Telomerase activity in central nervous system malignant lymphoma, Cancer, 86(6), 1050-1055, 19990401
  200. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality, Mechanisms of Ageing and Development, 110(3), 175-193, 19990401

Invited Lecture, Oral Presentation, Poster Presentation

  1. Screening of senescence-associated microRNAs having anti- proliferative effect in human cancer cells, 2016/10/08, Without Invitation, Japanese
  2. Biogenesisandbiologicalactivitiesofexosomesderivedfrom replicative senescent fibroblast cells, 2016/10/08, Without Invitation, Japanese
  3. Application of senescence-inducible microRNAs for cancer therapy, 2016/10/06, With Invitation, Japanese
  4. Induction of cancer stem cell dormancy and recurrence by Dox-inducible secondary reprogramming system, 2016/10/06, Without Invitation, Japanese
  5. The potential for applying PRPF19 siRNA to anti-cancer therapeutics, 2016/09/14, Without Invitation, Japanese
  6. The potential for applying PRPF19 siRNA to anti-cancer therapeutics, 2016/09/01, Without Invitation, Japanese
  7. p16-dependent induction of cell death by senescence-inducible microRNA in pancreatic cancer cells., 2016/08/31, Without Invitation, Japanese
  8. Nucleic Acid Therapeutics targeting microRNAs, 2016/07/30, With Invitation, Japanese
  9. The Significant Function Of EVs In Aging And Cancer, Hidetoshi Tahara, Extracellular Vesicles 2016, 2016/07/12, Without Invitation, English, Cambridge, UK
  10. Apoptotic Effect of Senescence-inducible microRNAs on Human Cancer Cell Lines, Masaki Kinehara,Yuki Yamamoto,Saori Fukunaga,Akira Shimamoto,Hidetoshi Tahara, 2016/06/24, Without Invitation, Japanese
  11. Inhibition of cancer cell growth by senescence-inducible miRNA, 2016/05/25, Without Invitation, Japanese
  12. "Non-coding RNAs Senescence-associated EVs from fibroblasts act as tumor suppressor at the tumor microenvironment.", Hidetoshi Tahara, 2016/02/18, Without Invitation, English, other
  13. Depletion of PRPF19 regulates cell fate between cellular senescence and cell death, 2015/12/03, Without Invitation, Japanese, other
  14. Histone variant H3.3 depletion induces cellular senescence in human diploid fibroblasts, 2015/12/02, Without Invitation, Japanese, other
  15. FunctionalanalysisofmiR-486inpancreaticcancer, 2015/10/10, Without Invitation, Japanese, other
  16. DepletionofPRPF19regulatescellfatebetweencellular senescence and cell death, 2015/10/10, Without Invitation, Japanese, other
  17. Thenovelmoleculartargetsforanti-cancerdrugtargeting transcription factors, 2015/10/10, Without Invitation, Japanese, other
  18. Identification of novel senescence-associated microRNAs in human fibroblasts, 2015/10/08, Without Invitation, Japanese, other
  19. Liquid Biopsy by using telomere and microRNA, JASIS2015, 2015/09/04, With Invitation, Japanese, other
  20. miR-486 has potential as nucleic acid medicine, 2015/08/27, Without Invitation, Japanese, published
  21. Senescence associated microRNA suppress cell proliferation in pancreatic cancer, 2015/08/27, Without Invitation, Japanese, published
  22. Understanding the mechanisms of the PRPF19 siRNA-mediated anti-tumor effect, 2015/08/27, Without Invitation, Japanese, published
  23. Cell-derived extracellular vesicle regulates cellular senescence, 2015/08/27, Without Invitation, Japanese, published
  24. The analysis of biological significance of extracellular vesicles in replicative senescence, 2015/08/27, Without Invitation, Japanese, published
  25. Role of phage display technology to proteomics, 2015/07/23, Without Invitation, Japanese, other
  26. Stable propagation of human pluripotent stem cells by dual inhibition of PKC and ERK signaling, 2015/05/26, Without Invitation, Japanese, other
  27. A large-scale membrane proteome analysis in scirrhous gastric cancer cell, 2015/05/26, Without Invitation, Japanese, other
  28. High-content screening of senescence-inducible microRNAs, 2015/05/26, Without Invitation, Japanese, other
  29. Analysis of senescence-associated miRNA that suppress pancreatic cancer, 2015/05/26, Without Invitation, Japanese, other
  30. Generation of Werner syndrome-specific iPS cells and challenges towards clinical application, 2015/05/26, Without Invitation, Japanese, other
  31. DNA Damage Response in Human Induced Pluripotent Stem Cells, Akira Shimamoto,Harunobu Kagawa,Hidehiko Kawai,Tetsushi Sakuma,Takashi Yamamoto,Bunsyo Shiotani,Hidetoshi Tahara, ICRR2015, 2015/05/25, Without Invitation, English, other
  32. Senescence-associated EVs act as tumor suppressors in the tumor microenvironment, Hidetoshi Tahara, International Soclety for Extracellular Vesicies 2015, 2015/04/25, Without Invitation, English, experimental
  33. Non-clinical study of locally administered microRNA nucleic acid medicine for malignant pleural mesothelioma, Hidetoshi Tahara, 2019/08/29, With Invitation, Japanese
  34. Circulating small RNAs in the serum as novel biomarkers for breast cancer detection, Yumiko Koi,Yasuhiro Tsutani, Yukie Nishiyama, Shinsuke Sasada, Tomoyuki Akita, NorioMasumoto, Takayuki Kadoya, Ryou-u Takahashi, Junko Tanaka, Morihito Okada, Hidetoshi Tahara, 2019/08/29, Without Invitation, Japanese
  35. Identification of PRPF19 as a novel target gene of senescence-associated microRNA; miR-27b-3p, Kimiyoshi Yano, Shisei Kan, Hiroki Sakagami, Ryou-u Takahashi and Hidetoshi Tahara, 2019/08/29, Without Invitation, Japanese
  36. The development of a novel nucleic acid drug against malignant pleural mesothelioma, Ayaka Nishiura, Yuki Yamamoto, Kimiyoshi Yano, Saori Fukunaga, Issei Shibuya, Ryou-u,Takahashi, Hidetoshi Tahara, 2019/08/28, Without Invitation, Japanese
  37. Senescent cells-derived extracellular vesicles repress tumour growth by transferring miR-127-3p and miR-134-5p., Megumi Okada,Kimiyoshi Yano,Shigeyuki Teranishi,Mariko Ikuo,Hidetoshi Tahara, ISEV2019, 2019/04/27, Without Invitation, English
  38. The factor affecting to the accuracy of extracellular small non-coding RNA biomarkers, Yukie Nishiyama,Yumiko Koi,Genki Nishimura, Eri Kojima,Morihito Okada,Hidetosi Tahara, ISEV2019, 2019/04/27, Without Invitation, English
  39. Isolation and characterization of bovine milk-derived Evs., Saori Fukunaga,Yuki Yamamoto,Hidetoshi Tahara, ISEV2019, 2019/04/26, Without Invitation, English
  40. BMP2 dependent osteoblast defferentiation is suppressed by multiplemyeloma-derived extracellular vesicles, Mariko Ikuo, ISEV2019, 2019/04/26, Without Invitation, English
  41. Characterization of extracellular vesicles (EVs) derived exRNA in cancer using NGS, Hidetoshi Tahara, qPCR dPCR & NGS 2019, 2019/03/18, With Invitation, English, Weihenstephan,Germany
  42. Telomere and microRNA in aging, 2018/10/10, With Invitation, Japanese
  43. MicroRNAs,isomiRs and tRFs are promising biomarkers as liquid biopsy for breast cancer detection., 2018/09/27, Without Invitation, Japanese
  44. A novel mechanism of p53-dependent cellular senescence by silencing of PRPF19, 2018/08/31, Without Invitation, Japanese
  45. Novel Senescence-Associated microRNA suppress malignant pleural mesothelioma, 2018/08/31, Without Invitation, Japanese
  46. A novel mechanism of p53-dependent cellular senescence by silencing of PRPF19, 2018/08/30, Without Invitation, Japanese
  47. Exploration of hemolysis-associated small non-coding RNA by Next Generation Sequence, 2018/08/30, Without Invitation, Japanese
  48. Novel Senescence-Associated microRNA suppress malignant pleural mesothelioma, 2018/08/29, Without Invitation, Japanese
  49. The relationship between human aging and advanced glycation end products of extracellular vesicles in serum., 2018/08/29, Without Invitation, Japanese
  50. Age-related expression change of circulating small non-coding RNAs, 2018/08/29, Without Invitation, Japanese
  51. Extracelluar vesicles derived from senescencet cells repress tumour growth via miRNAs, Mariko Ikuo,Megumi Okada, Shigeyuki Teranishi,Masaki Kinehara,Akira Shimamoto,Hidetoshi Tahara, ISEV2018, 2018/05/05, Without Invitation, English, Barcelona(Reino de España)
  52. Extracelluler small non-coding RNAs as promising biomarkers for early cancer detection, Yukie Nishiyama,Yumiko Koi,Genki Nishimura,Eri Kojima,Morihito Okada,Hidetoshi Tahara, ISEV2018, 2018/05/05, Without Invitation, English, Barcelona(Reino de España)
  53. Development of novel TRF2 inhibitor, Yoshitomo Shiroma,Go Fujita, Hidetoshi Tahara, EMBO Workshop, 2018/05/02, Without Invitation, English, Troia(Portugal)
  54. Application of exRNA and Circulating RNA for Early Detection of Cancer, Hidetoshi Tahara, Extracellular Vesicles as Biomarkers of Disease, 2017/12/13, Without Invitation, English
  55. Senescence cell - derived extracellular vesicles repress tumor growth, 2017/12/09, Without Invitation, Japanese
  56. Senescence cell - derived extracellular vesicles repress tumor growth, 2017/12/08, Without Invitation, Japanese
  57. Small non - coding RNA as biomarker promising early detection of pancreatic cancer, 2017/12/07, Without Invitation, Japanese
  58. Development of inhibitor of telomere binding protein using DSE-FRET assay, 2017/12/07, Without Invitation, Japanese
  59. Discovery and function analysis of RelA-DNA binding inhibitor using NF-kB DSE-FRET assay, 2017/12/07, Without Invitation, Japanese
  60. The association between glycation of sueface proteins on extracellular vesicles in serum and aging, 2017/12/06, Without Invitation, Japanese
  61. Senescence-associated microRNAs suppress malignant pleural mesothelioma cells, 2017/12/06, Without Invitation, Japanese
  62. Nucleic acid medicine based senescence-associated microRNAs for cancer therapy, 2017/12/06, Without Invitation, Japanese
  63. Mechanism of p53 activation via silenceing of PRPF19 in cellular senescence, 2017/12/06, Without Invitation, Japanese
  64. Validation of circulating microRNA using NGS, 2017/11/01, With Invitation, English
  65. "Cancer dormancy induced by Dox-inducible cancer stem cell model is maintained by BMP signaling", 2017/09/30, Without Invitation, Japanese
  66. "Novel senescence-associated microRNAs inhibit proliferation of intractable cancer cells", 2017/09/30, Without Invitation, Japanese
  67. The effect of TRF2 inhibitors in cancer cells, 2017/09/30, Without Invitation, Japanese
  68. PRPF19 is a novel potent molecular target for tumor suppression, 2017/09/30, Without Invitation, Japanese
  69. Senescence-associated microRNAs act as tumor suppressor hor both cancer stem cells and anti-cancer drug cancer cells, Hidetoshi Tahara, 2nd Global Insight Conference on Breast Cancer, 2017/09/05, Without Invitation, English, Rome
  70. Identification of serum preparation method that can get consistent circulating ncRNA profile., 2017/08/31, Without Invitation, Japanese
  71. Next-Generation Sequence analysis of exosomal small RNA isolated from cell culture media., 2017/08/30, Without Invitation, English
  72. miRNA in aging and cancer, 2017/08/28, With Invitation, English
  73. "An in vitro model for cancer stem cell dormancy and recurrence using tetinducible reprogramming system", 2017/07/01, With Invitation, Japanese
  74. Screening of senescence-inducible microRNAs for cancer therapy, 2017/07/01, Without Invitation, Japanese
  75. MicroRNA and exosome in Aging, Hidetoshi Tahara, 2017/06/15, With Invitation, English
  76. Extracellular RNA is promising biomarker for eary detection of cancers, Hidetoshi Tahara, Yukie Nishiyama,Yumiko Koui,Yuki Yamamoto,Genki Nishimura,Masaki Kinehara,Akira Shimamoto,Morito Okada,Hidetoshi Tahara, ISEV2017, 2017/05/19, Without Invitation, English, Toronto,Canada
  77. Circulating microRNAs as novel promising biomarkers for early detection of Tongue Cancer, Hidetoshi Tahara, ESMO ASIA, 2017/01/16, Without Invitation, Japanese, シンガポール

Social Activities

Organizing Academic Conferences, etc.

  1. 2012/08
  2. The 7th JARI Annual Meeting, 2015/08, 2015/08
  3. The 8th JARI Annual Meeting, 2016/08, 2016/08
  4. The 9th JARI Annual Meeting, 2017/08, 2017/09
  5. 2018/08, 2018/08