TOMOHARU YASUDA
Last Updated :2024/10/01
- Affiliations, Positions
- Graduate School of Biomedical and Health Sciences(Medicine), Professor
- E-mail
- yasudathiroshima-u.ac.jp
- Self-introduction
- We study how the immune system is regulated through the antigen receptor, signal transduction, and genetic programs for differentiation and proliferation to overcome infectious diseases, cancer, allergy, autoimmunity, aging, and tissue regeneration.
Basic Information
Major Professional Backgrounds
- 2020/04/01, Sanyo-Onoda City University, Visiting Professor
- 2019/08/01, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Immunology, Professor
- 2017/04/01, 2019/07/31, Medical Institute of Bioregulation, Kyushu University, Associate Professor
- 2017/02/01, 2017/03/31, National Center for Geriatrics and Gerontology, Postdoc
- 2011/08/01, 2017/01/31, Max Delbruck Center for Molecular Medicine, Scientist
- 2009/04/01, 2011/03/31, Japan Society for the Promotion of Science, JSPS Postdoctoral Fellow for Research Abroad
- 2008/12/01, 2011/07/31, Immune Disease Institute, Harvard Medical School, Reserch fellow
- 2005/04/01, 2008/11/30, Research Center for Allergy and Immunology, RIKEN, Research Fellow
- 2001/05/01, 2005/03/31, Medical Research Institute, Tokyo Medical and Dental University, Assistant Professor
- 2000/07/01, 2001/04/30, Japan Society for the Promotion of Science, Research Fellowship for Young Scientists (DC2)
Educational Backgrounds
- University of Tokyo, Graduate School of Medicine, Doctoral Course, Japan, 1998/04/01, 2001/04/30
- Kyushu University, Graduate School of Agriculture, Department of Genetic Resources Technology, Master's Course, Japan, 1996/04/01, 1998/03/31
- Kyushu University, Faculty of Agriculture, Japan, 1992/04/01, 1996/03/31
Academic Degrees
- Ph.D., The University of Tokyo
- M.Sc., Kyushu University
Educational Activity
- [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
- [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
- [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine
In Charge of Primary Major Programs
Research Fields
- Medicine,dentistry, and pharmacy;Basic medicine;Immunology
- Medicine,dentistry, and pharmacy;Basic medicine;Parasitology (including sanitary zoology)
Research Keywords
- B cell, Antibody, Vaccine, Tumor immunity, Immune surveillance, Epstein-Barr virus, Lymphoma, Leukemia, Allergy, Tissue regeneration
Affiliated Academic Societies
- Japanese Society for Immunology
- Japanese Cancer Association
- The Molecular Biology Society of Japan
Educational Activity
Course in Charge
- 2024, Undergraduate Education, Year, Biological Responses
- 2024, Undergraduate Education, 2Term, Introduction for medical research
- 2024, Undergraduate Education, Intensive, Practice for medical research
- 2024, Undergraduate Education, 1Term, Microbiology Immunology
- 2024, Liberal Arts Education Program1, 1Term, Introductory Seminar for First-Year Students
- 2024, Graduate Education (Master's Program) , First Semester, Seminar
- 2024, Graduate Education (Master's Program) , Second Semester, Seminar
- 2024, Graduate Education (Master's Program) , First Semester, Research
- 2024, Graduate Education (Master's Program) , Second Semester, Research
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
- 2024, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
- 2024, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Immunology
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Immunology
- 2024, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Immunology
- 2024, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Immunology
- 2024, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science
Research Activities
Academic Papers
- Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis, SCIENCE IMMUNOLOGY, 9(92), 20240202
- Mouse models of human multiple myeloma subgroups., Proc. Natl. Acad. Sci. U. S. A., 120, e2219439120, 20230307
- How should we deal with neoplastic disease and serious infections caused by Epstein-Barr virus?, Cancers, 15, 1-2889, 20230524
- Regulation mechanisms of CARMA1-Bcl10-MALT1 complex assembly inferred from the analysis of TRAF6-deficient cells, Genes Cells, 28(6), 411-421, 202306
- ★, Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, Commun. Biol., 6(1), 395, 20230411
- A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+T cells in a surface marker knock-in mouse, Exp. Gerontol., 174, 112130, 202304
- ★, Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen, Int. Immunol., 35(4), 197-207, 20230404
- ★, Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells, Cancers, 14(17), 4118, 20220825
- Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration, Cells, 11(11), 1754, 20220526
- Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis, Nat. Commun., 13(1), 1071, 20220228
- Potential role of inducible GPR3 expression under stimulated T cell conditions, J. Pharmacol. Sci., 148(3), 307-314, 202203
- A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing, PLOS Genet., 17(8), e1009686, 20210805
- Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells, Sci. Rep., 11(1), 5524, 20210309
- Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma, Front. Immunol., 12, 639844, 20210224
- A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8, Life Sci. Alliance, 4(4), e202000873, 20210211
- Functional Interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis., Proc. Natl. Acad. Sci. U. S. A., 117, 14421-14432, 20200623
- Measuring protein synthesis during cell cycle by Azidohomoalanine (AHA) labeling and flow cytometric analysis., Bio-Protocol, 9(8), e3215, 20190420
- Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis., Mol. Cell, 72(1), 84-98, 20181004
- ★, Mouse model for acute Epstein-Barr virus infection., Proc. Natl. Acad. Sci. U. S. A., 113(48), 13821-13826, 20161129
- Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1., Nat. Commun., 7, 12756, 20160927
- TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation., FEBS Lett., 590(18), 3264-3269, 201609
- Canonical NF-kB signaling is uniquely required for the long-term persistence of functional mature B cells., Proc. Natl. Acad. Sci. U. S. A., 113(18), 5065-5070, 20160503
- ★, miR-23∼27∼24 clusters control effector T cell differentiation and function., J. Exp. Med., 213(2), 235-249, 20160208
- PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones., Immunity, 43(6), 1075-1086, 20151215
- RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway., Nat. Commun., 6, 7367, 20150714
- Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kB activation., Science, 344(6185), 760-764, 20140516
- An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells., Nat. Commun., 5, 3755, 20140507
- Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice., Cold Spring Harb. Symp. Quant. Biol., 78, 020222, 20131115
- ★, Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model., Cell, 148(4), 739-751, 20120217
- ★, ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation., Sci. Signal., 4(169), ra25, 20110419
- Regulation of microRNA expression and abundance during lymphopoiesis., Immunity, 32(6), 828-839, 20100625
- Regulation of lymphocyte fate by Ras/ERK signals., Cell cycle, 7(23), 3634-3640, 200812
- ★, Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion., Immunity, 28(4), 499-508, 200804
- Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation., Nat. Med., 14(2), 188-193, 200802
- Dok-1 is a positive regulator of IL-4 signalling and IgE response., J. Biochem., 142(2), 257-263, 200708
- Dok-1 and Dok-2 are negative regulators of T cell receptor signaling., Int. Immunol., 19(4), 487-495, 200704
- The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans., Genes Cells, 12(3), 407-420, 200703
- Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases., Genes Cells, 11(2), 143-151, 200602
- PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1., J. Exp. Med., 202(10), 1423-1431, 20051121
- Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling., J. Exp. Med., 201(3), 333-339, 20050207
- Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress., Biochem. Biophys. Res. Commun., 334(2), 450-459, 20050826
- ★, Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia., J. Exp. Med., 200(12), 1681-1687, 20041220
- Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding., Genes Cells, 9(6), 601-607, 200406
- ★, Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells., J. Exp. Med., 196(1), 51-63, 20020701
- BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor., EMBO J., 21(1-2), 83-92, 20020115
- ★, Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-g2 activation by regulating B cell linker protein-PLC-g2 binding., J. Exp. Med., 191, 641-650, 20000221
- Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma., Biochem. Biophys. Res. Commun., 237, 313-317, 19970818
Publications such as books
- 2016, B Cell Receptor Signaling (ed, Kurosaki, T, and Wienands, J.). Current Topics in Microbiology and Immunology, MAP Kinase Cascades in Antigen Receptor Signaling and Physiology, Springer, 2016, Scholarly Book, Single work, Yasuda, T., 211-231
- 2004, B Cell Protocols (ed, Gu, H, and Rajewsky, K.), Methods Mol. Biol., 271, Analysis of B-cell signaling using DT40 B-cell line, Humana Press, 2004, Scholarly Book, Joint work, Yasuda, T., and Yamamoto, T., 261-270
Invited Lecture, Oral Presentation, Poster Presentation
- Immune Surveillance of Spontaneous Tumors Triggered by Latent Epstein-Barr Virus Infection, Yuqi Jin, Yun Guo, Megumi Sasatani, Kenji Kamiya, Tomoharu Yasuda, The 8th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2024/02/15, Without Invitation, English
- Large-scale comparative analysis of Epstein-Barr virus genome to unveil geography- and disease-associated variations, Taisei Fukushima, Shun Ohki, Rin Yoshizato, Tomoharu Yasuda., The 8th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science, 2024/02/15, Without Invitation, English
- The characterization of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M), Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda, The 52nd Annual Meeting of The Japanese Society for Immunology, 2024/01/17, Without Invitation, English
- Sequential exposure to different SARS-CoV-2 antigens induces broadly neutralizing antibodies in mice, 8. Hitoshi Azuma, Yohei Kawano, Akifumi Higashiura, Yasuo Kitajima, Shun Ohki, Tomoharu Yasuda., The 52nd Annual Meeting of The Japanese Society for Immunology, Without Invitation, English
- Immune Surveillance of Radiation-Induced Tumors Elicited by Latent Epstein-Barr Virus Oncogenes, Yuqi Jin, Yun Guo, Tomoharu Yasuda, The 52nd Annual Meeting of The Japanese Society for Immunology, 2024/01/17, Without Invitation, English
- The role of Polycomb group gene Eed in invariant NKT cell development and liver protection, Yun Guo, Yohei Kawano, Masamoto Kanno, Tomoharu Yasuda, The 52nd Annual Meeting of The Japanese Society for Immunology, 2024/01/17, Without Invitation, English
- Acquisition of tumor-specific T cell immunity by wide-spread viral molecule, Keita Yamane, Yohei Kawano, Shun Ohki, Yuri Matsuoka, Rin Yoshizato, Yumi Tamura, Yasuo Kitajima, Ryoka Tsukahara, Tomoharu Yasuda, The 52nd Annual Meeting of The Japanese Society for Immunology, 2024/01/17, Without Invitation, English
- Define The Direct Activation of Mycophenolate mofetil in Non-Hepatic Cells, Yusei Ota, Yuki Fujii, Hirotaka Kanoh, Rina Okihara, Mika Sasaki, Aki Ogawa-Iio, Sei Kondo, Keita Yamane, Yumi Tamura, Hirotoshi Ochi, Miki Senda, Kari Kopra, Harri Härmä, Toshiya Senda, Koh Takeuchi, Tomoharu Yasuda, Atsuo Sasaki, The 46th Annual Meeting of the Molecular Biology Society of Japan, 2023/12/06, Without Invitation, English
- Properties and functional analysis of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M)., Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., The 51th Annual Meeting of The Japanese Society for Immunology, 2022/12/07, Without Invitation
- Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T cells in response to EBV infected B cells., Yumi Tamura, Keita Yamane, Moeka Mori, Yohei Kawano, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., The 51st Annual Meeting of the Japanese Society for Immunology, 2022/12/07
- Polycomb group gene Eed is required for invariant NKT development and maturation., 2022/12/07
- Efficient CRISPR/Cas9-mediated precise gene repair in T cells to treat EBV-triggered primary HLH in mice and human, Li, X., Wirtz, T., Weber, T., Lowenstein, E.D., Sommermann, T., Tran, N.T., Danner, E., Graf, R., Zach, A., Lebedin, M., Yasuda, T., Kocks, C., de la Rosa, K., Kühn, R., Chu, V.T., and Rajewsky, K., International LIT Symposium, 2022/06/29
- Diversity and functional roles of G protein-coupled receptor 3 in nonneuronal cells., Tanaka, S., Shiraki, H., Guo, Y., Yanase, Y., Harada, K., Hide, I., Yasuda, T., Sakai, N., 2022/03/07
- B cell division in the heterogeneous pre-tumor microenvironment is required for lymphoma development., T. Yasuda, The 79th Annual Meeting of the Japanese Cancer Association, 2020/10/01
- EB virus LMP1-mediated host immunogenicity and cytotoxic T cell differentiation, T. Yasuda, 2019/09/14
- Mouse gene targeting using NEPA21 electroporator, T. Yasuda, Japanese Association for Laboratory Animal Science, 2019/05/15
- Modeling Epstein-Barr virus pathologies and immune surveillance in mice. International Congress on Oncogenic Herpesviruses and Associated Diseases,, Yasuda, T., Sommermann, T., Zhang, B., Rajewsky, K., International Congress on Oncogenic Herpesviruses and Associated Diseases, 2012/08/01
- Requirement for Erk1 and Erk2 MAP kinases in the early B cell development., Yasuda, T., Sanjo, H., Ogata, M., Kurosaki, T., 2007/11/20
- Cbl-b positively regulates Btk-mediated activation of phospholipase C-g2 in B cells., Yasuda, T., Tezuka, T., Kurosaki, T., Yamamoto, T., 17th Annual Meeting on Oncogenes, 2001
External Funds
Acceptance Results of Competitive Funds
- 2020, 2021
- 2020, 2023
- 2023, 2024
- KAKENHI(Grant-in-Aid for Scientific Research (B)), 2021, 2023
- KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2019, 2020
- KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2018, 2020
- 2017, 2017
- 2017, 2017
- 2017, 2017
- 2017, 2018
- 2008, 2008
- 2008, 2009
- 2006, 2007
- 2002, 2004
- 2001, 2002
- 2000, 2001
Social Activities
History as Peer Reviews of Academic Papers
- 2023, Frontiers in Immunology, 3
- 2023, International Immunology, Others, 1
- 2023, eLife, Others, 2
- 2022, Frontiers in Immunology, Editor, Editor, 1
- 2022, Cancers, Editor, Editor, 5
- 2022, Frontiers in Immunology, Reviewer, 2
- 2022, Hiroshima Journal of Medical Sciences, Reviewer, 1
- 2022, International Immunology, Reviewer, 3
- 2022, eLife, Reviewer, 3
- 2021, Frontiers in Immunology, Reviewer, 1
- 2021, eLife, Reviewer, 2
- 2021, International Immunology, Reviewer, 3
- 2020, Science Immunology, Reviewer, 1
- 2020, International Immunology, Reviewer, 1
- 2020, Immunity, Inflammation and Disease, Reviewer, 1
- 2020, Bioscience, Biotechnology, and Biochemistry, Reviewer, 5
- 2019, Frontiers in Microbiology, Editor, Editor, 1
- 2019, International Immunology, Reviewer, 1
- 2019, Hiroshima Journal of Medical Sciences, Reviewer, 1
- 2019, Bioscience, Biotechnology, and Biochemistry, Reviewer, 3
- 2018, International Immunology, Reviewer, 2
- 2018, eLife, Reviewer, 1
- 2018, Cellular Immunology, Reviewer, 1
- 2018, Bioscience, Biotechnology, and Biochemistry, Reviewer, 3
- 2017, Proceedings of the Japan Academy, Reviewer, 1
- 2017, Bioscience, Biotechnology, and Biochemistry, Reviewer, 2