TOMOHARU YASUDA

Last Updated :2023/12/05

Affiliations, Positions
Graduate School of Biomedical and Health Sciences(Medicine), Professor
E-mail
yasudathiroshima-u.ac.jp
Self-introduction
We study how the immune system is regulated through the antigen receptor, signal transduction, and genetic programs for differentiation and proliferation to overcome infectious diseases, cancer, allergy, autoimmunity, aging, and tissue regeneration.

Basic Information

Major Professional Backgrounds

  • 2020/04/01, Sanyo-Onoda City University, Visiting Professor
  • 2019/08/01, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Immunology, Professor
  • 2017/04/01, 2019/07/31, Medical Institute of Bioregulation, Kyushu University, Associate Professor
  • 2017/02/01, 2017/03/31, National Center for Geriatrics and Gerontology, Postdoc
  • 2011/08/01, 2017/01/31, Max Delbruck Center for Molecular Medicine, Scientist
  • 2009/04/01, 2011/03/31, Japan Society for the Promotion of Science, JSPS Postdoctoral Fellow for Research Abroad
  • 2008/12/01, 2011/07/31, Immune Disease Institute, Harvard Medical School, Reserch fellow
  • 2005/04/01, 2008/11/30, Research Center for Allergy and Immunology, RIKEN, Research Fellow
  • 2001/05/01, 2005/03/31, Medical Research Institute, Tokyo Medical and Dental University, Assistant Professor
  • 2000/07/01, 2001/04/30, Japan Society for the Promotion of Science, Research Fellowship for Young Scientists (DC2)

Educational Backgrounds

  • University of Tokyo, Graduate School of Medicine, Doctoral Course, Japan, 1998/04/01, 2001/04/30
  • Kyushu University, Graduate School of Agriculture, Department of Genetic Resources Technology, Master's Course, Japan, 1996/04/01, 1998/03/31
  • Kyushu University, Faculty of Agriculture, Japan, 1992/04/01, 1996/03/31

Academic Degrees

  • Ph.D., The University of Tokyo
  • M.Sc., Kyushu University

Educational Activity

  • [Bachelor Degree Program] School of Medicine : Program of Medicine : Medicine
  • [Master's Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Integrated Health Sciences : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Biomedical and Health Sciences : Division of Biomedical Sciences : Program of Medicine

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Basic medicine;Immunology
  • Medicine,dentistry, and pharmacy;Basic medicine;Parasitology (including sanitary zoology)

Research Keywords

  • B cell, Antibody, Vaccine, Tumor immunity, Immune surveillance, Epstein-Barr virus, Lymphoma, Leukemia, Allergy, Tissue regeneration

Affiliated Academic Societies

  • Japanese Society for Immunology
  • Japanese Cancer Association
  • The Molecular Biology Society of Japan

Educational Activity

Course in Charge

  1. 2023, Undergraduate Education, Year, Biological Responses
  2. 2023, Undergraduate Education, 2Term, Introduction for medical research
  3. 2023, Undergraduate Education, Intensive, Practice for medical research
  4. 2023, Undergraduate Education, 1Term, Microbiology Immunology
  5. 2023, Graduate Education (Master's Program) , First Semester, Seminar
  6. 2023, Graduate Education (Master's Program) , Second Semester, Seminar
  7. 2023, Graduate Education (Master's Program) , First Semester, Research
  8. 2023, Graduate Education (Master's Program) , Second Semester, Research
  9. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar
  10. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar
  11. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research
  12. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research
  13. 2023, Graduate Education (Master's Program) , First Semester, Physiology and Biological Chemistry
  14. 2023, Graduate Education (Master's Program) , 3Term, Seminar on Host Defense
  15. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Seminar on Immunology
  16. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Seminar on Immunology
  17. 2023, Graduate Education (Doctoral Program) , First Semester, Advanced Research on Immunology
  18. 2023, Graduate Education (Doctoral Program) , Second Semester, Advanced Research on Immunology
  19. 2023, Graduate Education (Doctoral Program) , 2Term, Trends of Genome Editing in Medical Science

Research Activities

Academic Papers

  1. Mouse models of human multiple myeloma subgroups., Proc. Natl. Acad. Sci. U. S. A., 120, e2219439120, 20230307
  2. How should we deal with neoplastic disease and serious infections caused by Epstein-Barr virus?, Cancers, 28, 411-421, 202306
  3. Regulation mechanisms of CARMA1-Bcl10-MALT1 complex assembly inferred from the analysis of TRAF6-deficient cells, Genes Cells, 28(6), 411-421, 202306
    Link to Paper Search Results by DOI
  4. ★, Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants, Commun. Biol., 6(1), 395, 20230411
    Link to Paper Search Results by DOI
  5. A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+T cells in a surface marker knock-in mouse, Exp. Gerontol., 174, 112130, 202304
    Link to Paper Search Results by DOI
  6. ★, Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen, Int. Immunol., 35(4), 197-207, 20230404
    Link to Paper Search Results by DOI
  7. ★, Concomitant Cytotoxic Effector Differentiation of CD4(+) and CD8(+) T Cells in Response to EBV-Infected B Cells, Cancers, 14(17), 4118, 20220825
    Link to Paper Search Results by DOI
  8. Efficient Isolation of Lymphocytes and Myogenic Cells from the Tissue of Muscle Regeneration, Cells, 11(11), 1754, 20220526
    Link to Paper Search Results by DOI
  9. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis, Nat. Commun., 13(1), 1071, 20220228
    Link to Paper Search Results by DOI
  10. Potential role of inducible GPR3 expression under stimulated T cell conditions, J. Pharmacol. Sci., 148(3), 307-314, 202203
    Link to Paper Search Results by DOI
  11. A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing, PLOS Genet., 17(8), e1009686, 20210805
    Link to Paper Search Results by DOI
  12. Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells, Sci. Rep., 11(1), 5524, 20210309
    Link to Paper Search Results by DOI
  13. Pathologically Relevant Mouse Models for Epstein-Barr Virus-Associated B Cell Lymphoma, Front. Immunol., 12, 639844, 20210224
    Link to Paper Search Results by DOI
  14. A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8, Life Sci. Alliance, 4(4), e202000873, 20210211
    Link to Paper Search Results by DOI
  15. Functional Interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis., Proc. Natl. Acad. Sci. U. S. A., 117, 14421-14432, 20200623
  16. Measuring protein synthesis during cell cycle by Azidohomoalanine (AHA) labeling and flow cytometric analysis., Bio-Protocol, 9(8), e3215, 20190420
  17. Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis., Mol. Cell, 72(1), 84-98, 20181004
  18. ★, Mouse model for acute Epstein-Barr virus infection., Proc. Natl. Acad. Sci. U. S. A., 113(48), 13821-13826, 20161129
  19. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1., Nat. Commun., 7, 12756, 20160927
  20. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation., FEBS Lett., 590(18), 3264-3269, 201609
  21. Canonical NF-kB signaling is uniquely required for the long-term persistence of functional mature B cells., Proc. Natl. Acad. Sci. U. S. A., 113(18), 5065-5070, 20160503
  22. ★, miR-23∼27∼24 clusters control effector T cell differentiation and function., J. Exp. Med., 213(2), 235-249, 20160208
  23. PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones., Immunity, 43(6), 1075-1086, 20151215
  24. RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway., Nat. Commun., 6, 7367, 20150714
  25. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kB activation., Science, 344(6185), 760-764, 20140516
  26. An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells., Nat. Commun., 5, 3755, 20140507
  27. Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice., Cold Spring Harb. Symp. Quant. Biol., 78, 020222, 20131115
  28. ★, Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model., Cell, 148(4), 739-751, 20120217
  29. ★, ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation., Sci. Signal., 4(169), ra25, 20110419
  30. Regulation of microRNA expression and abundance during lymphopoiesis., Immunity, 32(6), 828-839, 20100625
  31. Regulation of lymphocyte fate by Ras/ERK signals., Cell cycle, 7(23), 3634-3640, 200812
  32. ★, Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion., Immunity, 28(4), 499-508, 200804
  33. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation., Nat. Med., 14(2), 188-193, 200802
  34. Dok-1 is a positive regulator of IL-4 signalling and IgE response., J. Biochem., 142(2), 257-263, 200708
  35. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling., Int. Immunol., 19(4), 487-495, 200704
  36. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans., Genes Cells, 12(3), 407-420, 200703
  37. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases., Genes Cells, 11(2), 143-151, 200602
  38. PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1., J. Exp. Med., 202(10), 1423-1431, 20051121
  39. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling., J. Exp. Med., 201(3), 333-339, 20050207
  40. Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress., Biochem. Biophys. Res. Commun., 334(2), 450-459, 20050826
  41. ★, Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia., J. Exp. Med., 200(12), 1681-1687, 20041220
  42. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding., Genes Cells, 9(6), 601-607, 200406
  43. ★, Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells., J. Exp. Med., 196(1), 51-63, 20020701
  44. BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor., EMBO J., 21(1-2), 83-92, 20020115
  45. ★, Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-g2 activation by regulating B cell linker protein-PLC-g2 binding., J. Exp. Med., 191, 641-650, 20000221
  46. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma., Biochem. Biophys. Res. Commun., 237, 313-317, 19970818

Publications such as books

  1. 2016, B Cell Receptor Signaling (ed, Kurosaki, T, and Wienands, J.). Current Topics in Microbiology and Immunology, MAP Kinase Cascades in Antigen Receptor Signaling and Physiology, Springer, 2016, Scholarly Book, Single work, Yasuda, T., 211-231
  2. 2004, B Cell Protocols (ed, Gu, H, and Rajewsky, K.), Methods Mol. Biol., 271, Analysis of B-cell signaling using DT40 B-cell line, Humana Press, 2004, Scholarly Book, Joint work, Yasuda, T., and Yamamoto, T., 261-270

Invited Lecture, Oral Presentation, Poster Presentation

  1. Properties and functional analysis of cultured common lymphoid progenitor-derived monocytic cells (cCLP-M)., Yohei Kawano, Mizuki Moriyama, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., The 51th Annual Meeting of The Japanese Society for Immunology, 2022/12/07
  2. Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T cells in response to EBV infected B cells., Yumi Tamura, Keita Yamane, Moeka Mori, Yohei Kawano, Shun Ohki, Yasuo Kitajima, Tomoharu Yasuda., The 51st Annual Meeting of the Japanese Society for Immunology, 2022/12/07
  3. Polycomb group gene Eed is required for invariant NKT development and maturation., 2022/12/07
  4. Efficient CRISPR/Cas9-mediated precise gene repair in T cells to treat EBV-triggered primary HLH in mice and human, Li, X., Wirtz, T., Weber, T., Lowenstein, E.D., Sommermann, T., Tran, N.T., Danner, E., Graf, R., Zach, A., Lebedin, M., Yasuda, T., Kocks, C., de la Rosa, K., Kühn, R., Chu, V.T., and Rajewsky, K., International LIT Symposium, 2022/06/29
  5. Diversity and functional roles of G protein-coupled receptor 3 in nonneuronal cells., Tanaka, S., Shiraki, H., Guo, Y., Yanase, Y., Harada, K., Hide, I., Yasuda, T., Sakai, N., 2022/03/07
  6. B cell division in the heterogeneous pre-tumor microenvironment is required for lymphoma development., T. Yasuda, The 79th Annual Meeting of the Japanese Cancer Association, 2020/10/01
  7. EB virus LMP1-mediated host immunogenicity and cytotoxic T cell differentiation, T. Yasuda, 2019/09/14
  8. Mouse gene targeting using NEPA21 electroporator, T. Yasuda, Japanese Association for Laboratory Animal Science, 2019/05/15
  9. Modeling Epstein-Barr virus pathologies and immune surveillance in mice. International Congress on Oncogenic Herpesviruses and Associated Diseases,, Yasuda, T., Sommermann, T., Zhang, B., Rajewsky, K., International Congress on Oncogenic Herpesviruses and Associated Diseases, 2012/08/01
  10. Requirement for Erk1 and Erk2 MAP kinases in the early B cell development., Yasuda, T., Sanjo, H., Ogata, M., Kurosaki, T., 2007/11/20
  11. Cbl-b positively regulates Btk-mediated activation of phospholipase C-g2 in B cells., Yasuda, T., Tezuka, T., Kurosaki, T., Yamamoto, T., 17th Annual Meeting on Oncogenes, 2001

External Funds

Acceptance Results of Competitive Funds

  1. KAKENHI(Grant-in-Aid for Scientific Research (B)), 2021, 2023
  2. KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2019, 2020
  3. KAKENHI(Grant-in-Aid for Challenging Research (Exploratory)), 2018, 2020
  4. 2017, 2017
  5. 2017, 2017
  6. 2017, 2017
  7. 2017, 2018
  8. 2008, 2008
  9. 2008, 2009
  10. 2006, 2007
  11. 2002, 2004
  12. 2001, 2002
  13. 2000, 2001

Social Activities

History as Peer Reviews of Academic Papers

  1. 2022, Frontiers in Immunology, Editor, Editor, 1
  2. 2022, Cancers, Editor, Editor, 5
  3. 2022, Frontiers in Immunology, Reviewer, 2
  4. 2022, Hiroshima Journal of Medical Sciences, Reviewer, 1
  5. 2022, International Immunology, Reviewer, 3
  6. 2022, eLife, Reviewer, 3
  7. 2021, Frontiers in Immunology, Reviewer, 1
  8. 2021, eLife, Reviewer, 2
  9. 2021, International Immunology, Reviewer, 3
  10. 2020, Science Immunology, Reviewer, 1
  11. 2020, International Immunology, Reviewer, 1
  12. 2020, Immunity, Inflammation and Disease, Reviewer, 1
  13. 2020, Bioscience, Biotechnology, and Biochemistry, Reviewer, 5
  14. 2019, Frontiers in Microbiology, Editor, Editor, 1
  15. 2019, International Immunology, Reviewer, 1
  16. 2019, Hiroshima Journal of Medical Sciences, Reviewer, 1
  17. 2019, Bioscience, Biotechnology, and Biochemistry, Reviewer, 3
  18. 2018, International Immunology, Reviewer, 2
  19. 2018, eLife, Reviewer, 1
  20. 2018, Cellular Immunology, Reviewer, 1
  21. 2018, Bioscience, Biotechnology, and Biochemistry, Reviewer, 3
  22. 2017, Proceedings of the Japan Academy, Reviewer, 1
  23. 2017, Bioscience, Biotechnology, and Biochemistry, Reviewer, 2