Last Updated :2024/06/06

Affiliations, Positions
Graduate School of Integrated Sciences for Life, Associate Professor
Web Site
We are conducting molecular epidemiological studies on food poisoning bacteria such as Campylobacter and Bacillus cereus, as well as studies on plasmid antibiotic-resistant bacteria in collaboration with overseas research institutes.

Basic Information

Major Professional Backgrounds

  • 2006/04, 2006/08, University of Tsukuba, Postdoctral Fellow
  • 2006/08, 2008/08, University of Dundee, Ninewells hospital and Medical school, Postdoctoral Fellow
  • 2008/10, 2009/03, Japan International Research Center for Agricultural Sciences, Postdoctoral Researcher
  • 2009/04, 2013/10, Osaka University, Postdoctoral Researcher
  • 2013/10, 2015/03, Osaka University, Assistant Professor (Special Appointment)
  • 2015/04, 2016/03, Osaka Prefecture University, Assistant Professor (Special Appointment)
  • 2016/04, 2017/03, Osaka University, Graduate School of Pharmaceutical Sciences, Assistant Professor (Special Appointment)
  • 2017/07, 2021/03, National Institute of Health Sciences, Senior Researcher
  • 2021/04/01, Hiroshima University, Graduate School of Integrated Sciences for Life, Associate Professor

Academic Degrees

  • University of Tsukuba
  • University of Tsukuba

In Charge of Primary Major Programs

  • Food Science Program

Research Keywords

  • Food hygiene/Food Microbiology/Bacteriology/Antibiotic Resistant Bacteria/Intestinal Microbiota

Affiliated Academic Societies

  • American Society for Microbiology
  • Campylobacter
  • The Society of Antibacterial and Antifungal Agents, Japan
  • jJapanese Society for Bacteriology
  • Japanese Scoiety of Food Hygine and Safty
  • Japanese Society of Food Microbiology

Educational Activity

Course in Charge

  1. 2024, Undergraduate Education, First Semester, Graduation Thesis II
  2. 2024, Undergraduate Education, Second Semester, Graduation Thesis III
  3. 2024, Undergraduate Education, 3Term, Food Hygiene
  4. 2024, Undergraduate Education, Intensive, Laboratory Work in Food Hygiene
  5. 2024, Undergraduate Education, 2Term, Reading of Foreign Literature in Food Science
  6. 2024, Undergraduate Education, Intensive, (AIMS) Modern Food Science
  7. 2024, Undergraduate Education, 3Term, Modern Food Science
  8. 2024, Graduate Education (Master's Program) , 1Term, Special Lectures in Integrated Sciences for Life
  9. 2024, Graduate Education (Master's Program) , 1Term, Exercises in Food andAgriLife Science A
  10. 2024, Liberal Arts Education Program1, 4Term, Food and Life Science
  11. 2024, Liberal Arts Education Program1, 3Term, Food safety and health science
  12. 2024, Undergraduate Education, Intensive, Laboratory Work in General Biology I
  13. 2024, Undergraduate Education, 4Term, Introduction to Applied Biological Science II
  14. 2024, Undergraduate Education, 2Term, Introduction to Microbiology
  15. 2024, Undergraduate Education, 4Term, Research Front of Food and AgriLife Science
  16. 2024, Undergraduate Education, 3Term, Public Health
  17. 2024, Undergraduate Education, Second Semester, Graduation Thesis I
  18. 2024, Graduate Education (Master's Program) , 2Term, Exercises in Food andAgriLife Science A
  19. 2024, Graduate Education (Master's Program) , 3Term, Exercises in Food andAgriLife Science B
  20. 2024, Graduate Education (Master's Program) , 4Term, Exercises in Food andAgriLife Science B
  21. 2024, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Food andAgriLife Science
  22. 2024, Graduate Education (Master's Program) , 1Term, Microbiology for Food Safety I

Research Activities

Academic Papers

  1. ESBL-producing Atlantibacter hermannii harboring a plasmid encoding IS26 up and down stream of blaCTX-M-27 ,blaLAP-2, and qnrS1 isolated from an edible river Anabas testudineus fish, Microbiology Resource Announcements, 202404
  2. Analysis of the relationship between luminescence and toxicity of Vibrio carchariae pathogenic to shrimp, Fisheries Science, 71(6), 1236-1242, 2005
  3. Comparison of Vibrio harveyi strains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance, FEMS Microbiology Letter, 258(2), 194-199, 2006
  4. Study on the relationship of protease production and luminescence in Vibrio harveyi, Journal of Applied Microbiology, 101(1), 200-205, 2006
  5. The effect of copper concentration on the virulence of pathogenic Vibrio harveyi, Journal of Applied Microbiology, 102(5), 1300-1306, 2007
  6. Inhibitory effects of Bacillus probionts on growth and toxin production of Vibrio harveyi pathogens of shrimp, Letters in Applied Microbiology, 49(6), 679-84, 2009
  7. The gut microbiota in inflammatory bowel disease, Current Pharmaceutical Design, 15(13), 1528-1536, 2009
  8. Use of targeted antibiotics to treat ulcerative colitis, Gut, 58, 2009
  9. Streptococcus suis infection induces bacterial accumulation in the kidney, Microbial Pathogenesis, 50(2), 87-93, 2011
  10. Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand, Emerging Infectious Diseases, 17(5), 835-842, 2011
  11. Population-based study of Streptococcus suis infection in humans in Phayao province in northern Thailand, PLoS ONE, 7(2), e31265, 2012
  12. Influence of coffee ( Coffea arabica ) and galacto-oligosaccharide consumption on intestinal microbiota and the host responses, FEMS Microbiology Letter, 343(2), 2013
  13. Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections, Microbial Pathogenesis, 65, 2013
  14. The contribution of suilysin to the pathogenesis of Streptococcus suis meningitis, The Journal of Infectious Diseases, 209(10), 2013
  15. ★, Colloidal gold-based immunochromatographic strip test compromising optimised combinations of anti-S. suis capsular polysaccharide polyclonal antibodies for detection of Streptococcus suis, Biosensors and Bioelectronics, 60, 175-179, 2014
  16. Heat incubation inactivates streptococcal exotoxins and recombinant cholesterol-dependent cytolysins: suilysin, pneumolysin and streptolysin O, Current Microbiology, 69(5), 2014
  17. ★, Wide dissemination of extended-spectrum beta-lactamase-producing Escherichia coli in community residents in the Indochinese peninsula, Infection and Drug Resistance, 1-5, 2015
  18. Characteristics of Extended-Spectrum beta-Lactamase–Producing Escherichia coli in Retail Meats and Shrimp at a Local Market in Vietnam, Foodborne Pathogens and Disease, 12(8), 2015
  19. Widespread dissemination of extended-spectrum beta-lactamase-producing, multidrug-resistant Escherichia coli in livestock and fishery products in Vietnam, International Journal of Food Contamination, 2(1), 2015
  20. Spread of Antibiotic and Antimicrobial Susceptibility of ESBL-Producing Escherichia coli Isolated from Wild and Cultured Fish in the Mekong Delta, Vietnam, Fish Pathology, 2015
  21. ★, Frequent use of colistin-based drug treatment to eliminate extended-spectrum beta-lactamase-producing Escherichia coli in backyard chicken farms in Thai Binh Province, Vietnam, Tropical Animal Health and Production, 49(1), 2017
  22. ★, Water metagenomic analysis reveals low bacterial diversity and the presence of antimicrobial residues and resistance genes in a river containing wastewater from backyard aquacultures in the Mekong Delta, Vietnam, Environmental Pollution, 222, 2017
  23. ★, Common findings of bla CTX-M-55-encoding 104–139 kbp plasmids harbored by extended-spectrum beta-lactamase-producing Escherichia coli in pork meat, wholesale market workers, and patients with urinary tract infection in Vietnam, Current Microbiology, 74(2), 2017
  24. Impact of a Food Safety Campaign on Streptococcus suis Infection in Humans in Thailand, The American journal of tropical medicine and hygiene, 96(6), 2017
  25. Consumption of edible ice contaminated with Acinetobacter , Pseudomonas , and Stenotrophomonas is a risk factor for fecal colonization with extended spectrum beta-lactamase-producing Escherichia coli in Vietnam, Journal of Water and Health, 15(5), 2017
  26. Extended-spectrum beta-lactamase-producing Escherichia coli contributes to the survival of cefotaxime-susceptible E. coli under high concentrations of cefotaxime by acquisition of increased AmpC expression, FEMS Microbiology Letter, 365(5), 2018
  27. ★, Carriage of colistin-resistant, extended-spectrum beta-lactamase-producing Escherichia coli harboring the mcr-1 resistance gene after short-term international travel to Vietnam, Infection and Drug Resistance, 11, 391-395, 2018
  28. The Presence of Colisitn resistance gene mcr-1 and -3 in ESBL producing Escherichia coli isolated from food in Ho Chi Minh City, Vietnam, FEMS Microbiology Letter, 365(11), 2018
  29. Quantification and long-term carriage study of human extended-spectrum/AmpC beta-lactamase-producing Escherichia coli after international travel to Vietnam, Journal of Global Antimicrobial Resistance, 21, 2019
  30. Draft genome sequence of Stenotrophomonas maltophilia CRB139-1, Isolated from poultry meat in Japan, Microbiology Resource Announcements, 9(12), 2020
  31. Food Contamination with Antimicrobial-Resistant Bacteria in Vietnam, Japanese Journal of Food Microbiology, 37(3), 91-111, 2020
  32. Long-term grow-out affects Campylobacter jejuni colonization fitness in coincidence with altered microbiota and lipid composition in the cecum of laying hens, Frontiers in Veterinary Science, 8, 2022
  33. Untargeted phylogenetic group III of multi-drug-resistant Bacillus cereus isolated using Fraser medium from retail chickens in Ho Chi Minh City, Current Microbiology, 78(8), 3115-3123, 2021
  34. Extended-spectrum beta-lactamase-producing Escherichia coli harbouring sul and mcr-1 genes isolates from fish gut contents in the Mekong Delta, Vietnam, Letters in Applied Microbiology, 71(71), 78-85, 2020
  35. Wide Spread of Plasmid-Mediated Antibiotic Resistant Bacteria in Imported Fishery Products, Japanese Journal of Food Microbiology, 38(2), 67-77, 2021
  36. Streptococcal meningitis reveals the presence of residual streptococci and down-regulated aquaporin 4 in the brain, ARCHIVES OF MICROBIOLOGY, 203(10), 6329-6335, 202112
  37. Isolation of carbapenem-resistant Enterobacteriaceae harbouring NDM-1, 4, 5, OXA48 and KPC from river fish in Vietnam, FOOD CONTROL, 133, 202203
  38. Abundance of colistin-resistant Escherichia coli harbouring mcr-1 and extended-spectrum beta-lactamase-producing E. coli co-harbouring bla(CTX-M-55) or (-65) with bla(TEM) isolates from chicken meat in Vietnam, ARCHIVES OF MICROBIOLOGY, 204(2), 202202
  39. Genome Sequence of Carbapenemase-Producing Enterobacter cloacae 0102-4P-1 Harboring the IncC-Type Plasmid with a Multidrug Resistance Site Encoding bla(NDM)(-1), Isolated from Commercially Imported Shrimp, MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 11(5), 20220519
  40. Prevalence and Characterization of Gentamicin Resistance Genes in Escherichia coli Isolates from Beef Cattle Feces in Japan, CURRENT MICROBIOLOGY, 79(8), 202208
  41. Frequent contamination of edible freshwater fish with colistin-resistant Escherichia coli harbouring the plasmid-mediated mcr-1 gene, MARINE POLLUTION BULLETIN, 184, 2022
  42. IncHI2 Plasmid Encoding bla(CTX-M-55) and mcr-1.1 in Salmonella enterica SE20-C72-2 and Escherichia coli EC20-C72-1 Isolates from the Edible River Fish Anabas testudineus, MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 12(7), 20230718
  43. Common presence of plasmid encoding blaCTX-M-55 in extended- spectrum /3-lactamase-producing Salmonella enterica and Escherichia coli isolates from the same edible river fish, JOURNAL OF MICROORGANISM CONTROL, 28(2), 49-56, 2023
  44. Carbapenem-Resistant Citrobacter freundii and Escherichia coli Harboring a Common IncC-Type Plasmid Encoding IS26 Upstream of bla(NDM-1,) sul1, aph(3 ')-VI, and qacE Isolated from Edible Mastacembelidae Fish, MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 12(5), 20230517
  45. ESBL-producing Vibrio vulnificus and V. alginolyticus harbour a plasmid encoding ISEc9 upstream of bla(CTX-M-55) and qnrS2 isolated from imported seafood, ARCHIVES OF MICROBIOLOGY, 205(6), 202306
  46. Detection of chromosome-mediated blaNDM-1-carrying Aeromonas spp. in the intestinal contents of fresh water river fish in Ho Chi Minh City, Vietnam, Marine Pollution Bulletin, 198, 115812, 20231202
  47. Simple and quick detection of extended-spectrum beta-lactamase and carbapenemase-encoding genes using isothermal nucleic acid amplification techniques, Journal of Microorganism Control, 202312
  48. IncA/C plasmid encoding blaCTX-M-55, in non-O1 Vibrio cholerae isolates from the edible river fish Mastacembelus sp., Microbiology Resource Announcement, 202401
  49. Edible river fish-derived extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales harboring transferable plasmids encoding blaCTX-M-15, blaCTX-M- 27, and blaCTX-M-55, One Health, 202401
  50. Acquisition of third-generation cephalosporin resistance genes blaCTX-M-55, blaCTX-M-65, and blaCMY-2 leads to quinolone resistance in colistin-resistant Escherichia coli harbouring mcr-1 gene, Journal of Food Saftey, 202402

Invited Lecture, Oral Presentation, Poster Presentation

  1. Analysis of the relationship between luxR gene expression and toxicity of cell extracts of Vibrio sp. pathogenic to shrimp, T. Nakayama, Asia-Pacific Aquaculture, 2003/09/23, Without Invitation, English
  2. Copper addition to control virulence of pathogenic Vibrio against penaeid shrimp, T. Nakayama, 7th Asian Fisheries Forum, 2004/12/03, Without Invitation, English
  3. Recognition of various toxins from Vibrio carchariae and Vibrio harveyi, T. Nakayama,, N. Nomura, M. Matsumura, Vibrio 2005, 2005/11/06, Without Invitation, English
  4. The effect of copper on the luminosity, cytotoxicity and toxic substance production of Vibrio harveyi, T.Nakayama,, N.Nomura, M.Matsumura, 11th International symposium on microbial ecology, 2006/08/20, Without Invitation, English
  5. Use of antibiotics to eradicate bacterial pathogens colonising the colonic mucosa in ulcerative colitis patients, T. Nakayama,, K.L. Blackett, H. Steed, S. Macfarlane, N. Reynolds, JH. Cummings and GT. Macfarlane, Society for General Microbiology annual meeting, Without Invitation, English
  6. Effects of antibiotics on mucosal bacteria in ulcerative colitis patients, T.Nakayama,, K.L. Blackett, H. Steed, S. Macfarlane, N. Reynolds, JH. Cummings and GT. Macfarlane, American Society for Microbiology 108th general meeting, 2008/06/01, Without Invitation, English
  7. Association of haemolytic activity of human isolates of S. suis serotype 2 with their capacity of crossing the blood-CSF barrier, T. Nakayama, International Union of Microbiological Societies 2011 Congress, Without Invitation, English
  8. Suilysin plays an important role in intestinal translocation in the mouse loop model, T. Nakayama, 1st International work shop on Streptococcus suis, 2013/08/13, Without Invitation, English
  9. Low bacterial diversity and the presence of antimicrobial residues and antimicrobial resistance genes in a river containing wastewater from backyard aquacultures in the Mekong Delta, Vietna, T. Nakayama, 8th Congress of European Microbiologists, 2019/07/07, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2024, 2024
  2. 2024, 2026
  3. 2024, 2024
  4. 2023, 2023
  5. 2024, 2024
  6. 2023, 2025
  7. 2022, 2024
  8. 2009, 2011
  9. 2010, 2010
  10. 2012, 2014
  11. 2017, 2017
  12. 2018, 2020
  13. 2018, 2022
  14. 2018, 2021
  15. 2021, 2022

Social Activities

History as Peer Reviews of Academic Papers

  1. African Journal of Microbiology, Reviewer
  2. Japanese Journal of Food Microbiology, Reviewer
  3. Biocontrol Science, Reviewer
  4. Journal of Veterinary Medical Science, Reviewer
  5. Environmental Pollution, Reviewer