HAJIME OGINO

Last Updated :2022/11/01

Affiliations, Positions
Institute for Amphibian Biology, Professor
E-mail
oginohajhiroshima-u.ac.jp
Self-introduction
We are studying genomic and epigenomic regulations of development and regeneration using the pipid frog Xenopus and other vertebrates as model systems. Our goal is to understand the evolutionary mechanisms that underlie the diversity of body plans and regenerative abilities.

Basic Information

Major Professional Backgrounds

  • 1995/04, 2002/12, Nara Institute of Science and Technology, Research Associate
  • 2000/04, 2002/04, University of Virginia
  • 2002/04, 2007/12, University of Virginia, Research Scientist
  • 2008/01, 2012/03, Nara Institute of Science and Technology, Associate Professor (Special Appointment)
  • 2012/04, 2013/03, Nara Institute of Science and Technology
  • 2013/04, 2016/12, Nagahama Institute of Bio-Science and Technology, Professor
  • 2017/01/01, Hiroshima University, Amphibian Research Center, Professor

Educational Backgrounds

  • TOHOKU UNIVERSITY, Faculty of Science, Department of Biology, Japan, 1987/04, 1991/03
  • Kyoto University, Graduate School of Science, Department of Biophysics, Master course, Japan, 1991/04, 1993/03
  • Kyoto University, Graduate School of Science, Department of Biophysics, Ph.D. course, Japan, 1993/04, 1995/03

Academic Degrees

  • Master of Science, Kyoto University
  • Ph.D., Kyoto University

Educational Activity

  • [Bachelor Degree Program] School of Science : Biological Sciences : Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Master's Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Basic Biology
  • [Doctoral Program] Graduate School of Integrated Sciences for Life : Division of Integrated Sciences for Life : Program of Biomedical Science

Research Fields

  • Biology;Biological Science;Developmental biology
  • Biology;Basic biology;Evolutionary biology
  • Biological Sciences;Genome science;Genome biology
  • Biology;Biological Science;Molecular biology

Research Keywords

  • Development, Regeneration, Genome Evolution, Transcriptional Regulation, Xenopus

Affiliated Academic Societies

  • Japanese Society of Developmental Biologists, The Molecular Biology Society of Japan, The Zoological Society of Japan

Educational Activity

Course in Charge

  1. 2022, Liberal Arts Education Program1, 3Term, Introduction to Biology
  2. 2022, Liberal Arts Education Program1, 3Term, The life science of amphibians
  3. 2022, Liberal Arts Education Program1, 2Term, Introductory Seminar for First-Year Students
  4. 2022, Undergraduate Education, 2Term, Advanced Biology
  5. 2022, Undergraduate Education, 1Term, Basic Biological Science A
  6. 2022, Undergraduate Education, 3Term, Regulation of Animal Morphology
  7. 2022, Undergraduate Education, First Semester, Special Study for Graduation
  8. 2022, Undergraduate Education, Second Semester, Special Study for Graduation
  9. 2022, Undergraduate Education, Second Semester, Seminar for Amphibian Biology
  10. 2022, Undergraduate Education, Second Semester, Practice for Fundamental Biology IV
  11. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Basic Biology A
  12. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Basic Biology A
  13. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Basic Biology B
  14. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Basic Biology B
  15. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Basic Biology
  16. 2022, Graduate Education (Master's Program) , 4Term, Cell Dynamics and Genomics
  17. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar A
  18. 2022, Graduate Education (Master's Program) , 3Term, Biomedical Science Seminar B
  19. 2022, Graduate Education (Master's Program) , 3Term, Introduction to Disease Models
  20. 2022, Graduate Education (Master's Program) , 1Term, Exercises in Biomedical Science A
  21. 2022, Graduate Education (Master's Program) , 2Term, Exercises in Biomedical Science A
  22. 2022, Graduate Education (Master's Program) , 3Term, Exercises in Biomedical Science B
  23. 2022, Graduate Education (Master's Program) , 4Term, Exercises in Biomedical Science B
  24. 2022, Graduate Education (Master's Program) , Academic Year, Research for Academic Degree Dissertation in Biomedial Science
  25. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar C
  26. 2022, Graduate Education (Doctoral Program) , Academic Year, Research for Academic Degree Dissertation in Integrated Life Sciences
  27. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar D
  28. 2022, Graduate Education (Doctoral Program) , 3Term, Biomedical Science Seminar E
  29. 2022, Graduate Education (Master's Program) , 4Term, Introduction to Genetics and Genomics

Research Activities

Academic Papers

  1. Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction, Proceedings of the National Academy of Sciences of the United States of America, 119(33), 20220816
  2. Optimization of CRISPR/Cas9-mediated gene disruption in Xenopus laevis using a phenotypic image analysis technique, DEVELOPMENT GROWTH & DIFFERENTIATION, 64(4), 219-225, 20220326
  3. Invention sharing is the mother of developmental biology (Part 3), Development Growth and Differentiation, 64(1), 20220131
  4. Invention sharing is the mother of developmental biology., Development, growth & differentiation, 63(9), 20211230
  5. Invention sharing is the mother of developmental biology., Development, growth & differentiation, 63(8), 20211028
  6. Spontaneous neoplasia in the western clawed frog Xenopus tropicalis, microPublication Biology, 10.17912/micropub.biology.000294, 20200831
  7. Heterogeneity of synonymous substitution rates in the Xenopus frog genome, PLOS ONE, 15(8), 20200807
  8. Complete mitochondrial genome of Hynobius dunni (Amphibia, Caudata, Hynobiidae) and its phylogenetic position, MITOCHONDRIAL DNA PART B-RESOURCES, 5(3), 2241-2242, 20200702
  9. Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken, SCIENTIFIC REPORTS, 9, 20190829
  10. Xenopus Resources: Transgenic, Inbred and Mutant Animals, Training Opportunities, and Web-Based Support, FRONTIERS IN PHYSIOLOGY, 10, 20190425
  11. Functional properties of axolotl transient receptor potential ankyrin 1 revealed by the heterologous expression system, NEUROREPORT, 30(5), 323-330, 20190320
  12. Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers, ELIFE, 8, 20190108
  13. Draft genome of Dugesia japonica provides insights into conserved regulatory elements of the brain restriction gene nou-darake in planarians, ZOOLOGICAL LETTERS, 4, 20180829
  14. Co-accumulation of cis-regulatory and coding mutations during the pseudogenization of the Xenopus laevis homoeologs six6.L and six6.S, DEVELOPMENTAL BIOLOGY, 427(1), 84-92, 20170701
  15. Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis, DEVELOPMENTAL BIOLOGY, 426(2), 301-324, 20170615
  16. Asymmetrically reduced expression of handl homeologs involving a single nucleotide substitution in a cis-regulatory element, DEVELOPMENTAL BIOLOGY, 425(2), 152-160, 20170515
  17. Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells., PloS one, 11(9), 2016
  18. ★, Genome evolution in the allotetraploid frog Xenopus laevis., Nature, 538(7625), 2016
  19. Identification of distal enhancers for Six2 expression in pronephros, International Journal of Developmental Biology, 59(4-6), 241-246, 20150101
  20. Epigenetic modification maintains intrinsic limb-cell identity in Xenopus limb bud regeneration, DEVELOPMENTAL BIOLOGY, 406(2), 271-282, 2015
  21. Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates, BMC Biology, 12, 20140529
  22. Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration., Developmental biology, 396(1), 2014
  23. Essential roles of epithelial bone morphogenetic protein signaling during prostatic development., Endocrinology, 155(7), 2014
  24. Differential use of paralogous genes via evolution of cis-regulatory elements for divergent expression specificities, New Principles in Developmental Processes, 279-289, 20131101
  25. Loss of cell-extracellular matrix interaction triggers retinal regeneration accompanied by Rax and Pax6 activation, Genesis, 51(6), 410-419, 20130101
  26. Comparative genomics-based identification and analysis of cis-regulatory elements, Methods in Molecular Biology, 917, 245-263, 20121112
  27. Dynamic in vivo binding of transcription factors to cisregulatory modules of cer and gsc in the stepwise formation of the Spemann-Mangold organizer, Development, 139(9), 1651-1661, 20120501
  28. Transcription factors involved in lens development from the preplacodal ectoderm., Developmental biology, 363(2), 2012
  29. Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus., The International journal of developmental biology, 56(4), 2012
  30. ★, Evolution of a tissue-specific silencer underlies divergence in the expression of pax2 and pax8 paralogues., Nature communications, 3, 848, 2012
  31. Different requirement for wnt/beta-catenin signaling in limb regeneration of larval and adult Xenopus, PLoS ONE, 6(7), 20110801
  32. Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR, Developmental Biology, 344(1), 158-171, 20100801
  33. ★, The genome of the western clawed frog xenopus tropicalis, Science, 328(5978), 633-636, 20100430
  34. Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm, DEVELOPMENTAL BIOLOGY, 342(1), 110-120, 2010
  35. Resources and transgenesis techniques for functional genomics in Xenopus., Development, growth & differentiation, 51(4), 2009
  36. ★, Convergence of a head-field selector Otx2 and Notch signaling: a mechanism for lens specification, DEVELOPMENT, 135(2), 249-258, 2008
  37. Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration, DEVELOPMENTAL BIOLOGY, 306(1), 170-178, 2007
  38. Highly efficient transgenesis in Xenopus tropicalis using I-SceI meganuclease, MECHANISMS OF DEVELOPMENT, 123(2), 103-113, 2006
  39. ★, High-throughput transgenesis in Xenopus using I-SceI meganuclease, NATURE PROTOCOLS, 1(4), 1703-1710, 2006
  40. Temporal expression of L-Maf and RaxL in developing chicken retina are arranged into mosaic pattern., Gene expression patterns : GEP, 4(5), 2004
  41. Construction of a set of full-length enriched cDNA libraries as genomics tools for Xenopus tropicalis research, Current Genomics, 4(8), 635-644, 20031101
  42. The stability of the lens-specific maf protein is regulated by fibroblast growth factor (FGF)/ERK signaling in lens fiber differentiation, JOURNAL OF BIOLOGICAL CHEMISTRY, 278(1), 537-544, 2003
  43. L-Maf, a downstream target of Pax6, is essential for chick lens development, Mechanisms of Development, 116(1-2), 61-73, 20020730
  44. Xenopus tropicalis transgenic lines and their use in the study of embryonic induction, DEVELOPMENTAL DYNAMICS, 225(4), 522-535, 2002
  45. Isolation, characterization, and expression analysis of zebrafish large Mafs, Journal of Biochemistry, 129(1), 139-146, 20010101
  46. Sequential activation of transcription factors in lens induction, Development Growth and Differentiation, 42(5), 437-448, 20001108
  47. Regulation of lens fiber cell differentiation by transcription factor c-Maf., The Journal of biological chemistry, 274(27), 1999
  48. ★, Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf., Science (New York, N.Y.), 280(5360), 1998
  49. Developmental regulation of the chicken beta B1-crystallin promoter in transgenic mice., Mechanisms of development, 57(1), 1996
  50. Cryo-injury procedure-induced cardiac regeneration shows unique gene expression profiles in the newt Pleurodeles waltl, Developmental Dynamics, 251(5), 864-876, 20211228

Invited Lecture, Oral Presentation, Poster Presentation

  1. Morphological and behavioral characteristics of Xenopus tropicalis inbred strains in NBRP., Igawa, T., Suzuki, M., Suzuki, N., Kashiwagi, A., Kashiwagi, K., Ochi, H. and *Ogino, H., 18th International Xenopus Conference, 2021/08/19, With Invitation, English
  2. Generation of Xenopus tropicalis inbred strains and their genome polymorphism data by NBRP in Japan., Igawa, T., Suzuki, M., Suzuki, N., Kashiwagi, A., Kashiwagi, K., Ochi, H. and *Ogino, H., 2019 Xenopus Resources and Emerging Technology Meeting, 2019/10/13, With Invitation, English, Marine Biological Station, Woods Hole, MA, USA
  3. Current trends in Xenopus research, Ogino, H., The 10th NIBB International Practical Course "Genome Editing and Imaging of Fish and Amphibians", 2018/09/25, With Invitation, English
  4. Geneolgy and pedigrees of inbreeding strains of Xenopus tropicalis., Igawa, T., Kashiwagi, A., Kashiwagi, K., Suzuki, N., Watanabe, A., Suzuki, A., Noble, A., Guille, M., Simpson, D. E., Horb, M. E., Fujii, T., Sumida, M. and Ogino, H., 17th International Xenopus Conference, 2018/08/14, Without Invitation, English
  5. The launching of Amphibian Research Center (ARC) at Hiroshima University as the core facility of Xenopus resource in Japan., Ogino, H. and Suzuki, A., 17th International Xenopus Conference, 2018/08/12, With Invitation, English
  6. Cis-regulatory Evolution Following "Ancient" and "Recent" Genome Duplication Events in Vertebrates., Ogino, H., International Symposium at Hiroshima University: Amphibian development, regeneration, evolution and beyond, 2018/03/14, With Invitation, English
  7. The hypomorphic mutations hidden in the allotetraploid genome of Xenopus laevis, Tanouchi, M., Ochi, H., Kawaguchi, A., Igawa, T., Iwata, Y., Sakagami, K. and Ogino, H., International Symposium at Hiroshima University: Amphibian development, regeneration, evolution and beyond, 2018/03/13, Without Invitation, English
  8. Arid3a, a component of H3K9me3 demethylases, regulates the regeneration of the nephric duct through the evolutionary conserved regeneration signal response enhancer, Suzuki, N., Ogino, H. and Ochi, H., International Symposium at Hiroshima University: Amphibian development, regeneration, evolution and beyond, 2018/03/13, Without Invitation, English
  9. The launching of Amphibian Research Center (ARC) at Hiroshima University as the core facility of Xenopus resource in Japan., Ogino, H. and Suzuki, A., Xenopus Resources and Emerging Technologies Meeting, 2017/08/28, With Invitation, English
  10. Modification of cell differentiation competence by histone H3K27 demethylases and their involvement in tissue regeneration in Xenopus, Ogino, H., Sudou, N., Kawaguchi, A., Ochi, H., Kamiguchi, S. and Kasahara, H., The joint meeting of the 22nd international congress of zoology & the 87th meeting of the zoological society of Japan, 2016/11/15, With Invitation, English, OIST, Okinawa, Japan
  11. Xenopus as a useful resource for studying gene evolution and disease-causing mutations, Ogino, H., International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research, 2016/03/18, With Invitation, English, NIBB, Okazaki, Aichi, Japan
  12. Application of the transgenic Xenopus system for EvoDevo research: Evolution of a tissue-specific silencer underlies divergence in the expression of paralogues, Ogino, H., The 3rd NIBB-TLL-DBS/NUS Joint International Practical Course, 2014/09/30, With Invitation, English, NIBB, Okazaki, Aichi, Japan
  13. Evolution of a tissue-specific silencer underlies divergence in the expression of paralogues, Ogino, H., International symposium: Frontiers in Amphibian biology: Endangered species conservation and genome editing, 2014/03/27, With Invitation, English, Hiroshima University, Higashi-Hiroshima, Hiroshima, Japan
  14. Modification of cell differentiation competence by histone H3K27 demethylases and its implication for organ regeneration, Ogino, H., Sudou, N., Kawaguchi, A. and Ochi, H., The 36th MBSJ annual meeting, 2013/12/03, With Invitation, English, Kobe, Hyogo, Japan
  15. Evolution of a tissue-specific silencer underlies divergence in the expression of paralogues, Ogino, H., Ochi, H., Tamai, T., Nagano, H., Kawaguchi, A. and Sudou, N., The 45th JSDB meeting symposium "Evolution/Diversity/Early Development/Morphogen", 2012, With Invitation, English, Kobe, Hyogo, Japan
  16. Evolution of a fail-safe regulatory system after genome duplications in chordates, Ochi, H., Uchiyama, C., Kawaguchi, A., Tamai, T. and *Ogino, H., NAIST Grobal COE International Symposium, 2010, With Invitation, English, NAIST, Ikoma, Nara, Japan
  17. Conservation and neofunctionalization of cis-regulatory elements in paralog evolution, Ogino, H., Ochi, H. and Uchiyama, C., The 33th MBSJ annual meeting symposium "Development and Regeneration", 2010, With Invitation, English, Kobe, Hyogo, Japan
  18. Evolution of cis-regulatory mechanisms in paralog formation, Ogino, H. and Ochi, H., The 43th JSDB meeting symposium "EcoEvoDevo & Comparative Genomics", 2010, With Invitation, English, Kyoto, Japan

Social Activities

Other Social Contributions

  1. Development, Growth & Differentiation, Special Issue: METHODS & PROTOCOLS (PART 3), Editor, Development, Growth & Differentiation, Special Issue: METHODS & PROTOCOLS (PART 3), Editor, Wiley, Development, Growth & Differentiation, 2022/01/31, 2022/01/31, Lecturer, Newspaper or magazine, Researchesrs
  2. Development, Growth & Differentiation, Special Issue: METHODS & PROTOCOLS (PART 2), Editor, Development, Growth & Differentiation, Special Issue: METHODS & PROTOCOLS (PART 2), Editor, Wiley, Development, Growth & Differentiation, 2021/12/30, 2021/12/30, Editer, Newspaper or magazine, Researchesrs
  3. Development, Growth & Differentiation, Special Issue: METHODS & PROTOCOLS (PART 1), Editor, Development, Growth & Differentiation, Special Issue: METHODS & PROTOCOLS (PART 1), Editor, Wiley, Development, Growth & Differentiation, 2021/10/28, 2021/10/28, Editer, Newspaper or magazine, Researchesrs
  4. Open school for studying Frogs and Newts, Toshinori Hayashi, Takeshi Igawa, Makoto Suzuki, Nanoka Suzuki and Hajime Ogino, 2020/02/26, 2020/02/28, Hiroshima University Amphibian Research Center, Lecturer, Research advise, College students
  5. The 4th technical training course (customized) of National Bioresource Project (NBRP), Nanoka Suzuki and Hajime Ogino, 2019/11/12, 2019/11/19, Hiroshima University Amphibian Research Center, Lecturer, Research advise, Graduate students
  6. The 2nd technical training course (customized) of National Bioresource Project (NBRP), Nanoka Suzuki, Takeshi Igawa, Hajime Ogino and Toshinori Hayashi, 2019/10/24, 2019/10/25, Hiroshima University Amphibian Research Center, Lecturer, Research advise, Graduate students
  7. The 1st technical training course (customized) of National Bioresource Project (NBRP), Nanoka Suzuki and Hajime Ogino, 2019/07/22, 2019/07/24, Hiroshima University Amphibian Research Center, Lecturer, Research advise, Graduate students

History as Peer Reviews of Academic Papers

  1. 2022, Development, Growth & Differentiation, Others, Reviewer, 2
  2. 2022, Developmental Dynamics, Others, Reviewer, 1
  3. 2021, Development, Growth & Differentiation, Editor, Communicating Editor, 3
  4. 2021, Developmental Dynamics, Others, Reviewer, 1
  5. 2020, Developmental Dynamics, Others, Reviewer, 1
  6. 2019, Developmental Dynamics, Others, Reviewer, 1
  7. 2019, Development Growth and Differentiation, Others, Reviewer, 1
  8. 2019, Zoological Letters, Others, Reviewer, 1