MICHIHITO KYO

Last Updated :2026/07/06

Affiliations, Positions
Research Institute for Radiation Biology and Medicine, Assistant Professor
E-mail
mkyohiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2026/04/01, Graduate School of Biomedical and Health Sciences, Hiroshima University, Department of Emergency and Critical Care Medicine, Associate professor
  • 2024/06/01, Hiroshima University, Research Institute for Radiation Biology and Medicine, Department of Radiation Disaster Medicine, Assistant Professor
  • 2023/12/01, 2024/05/31, Hiroshima University, Radiation Disaster Medical Support Center, Assistant Professor (Special Appointment)
  • 2022/04/01, 2023/10/31, Massachusetts General Hospital, Harvard Medical School, Department of Emergency Medicine, Research Fellow

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical & Health Sciences, Japan, 2016/04, 2020/03

Academic Degrees

  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical surgery;Emergency medicine

Research Keywords

  • Emergency medicine, Intensive care medicine, Infectious diseases, Sepsis, ARDS, Disaster medicine

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Intensive, Practice for medical research

Research Activities

Academic Papers

  1. Should we abandon airway pressure release ventilation in pediatric acute respiratory distress syndrome?, American Journal of Respiratory and Critical Care Medicine, 198(11), 1459-1460, 20181201
  2. Ultra-Long Polymyxin B Hemoperfusion and Its Effect on Vasopressor Dosage and Organ Dysfunction in Patients With Septic Shock Requiring High-Dose Norepinephrine: A Post Hoc Analysis of a Prospective Cohort Study, Artificial Organs, 50(3), 458-467, 20260301
  3. Polymyxin B Hemoperfusion for Patients With Septic Shock Requiring High-Dose Norepinephrine: A Multicenter Prospective Cohort Study, Critical Care Explorations, 7(10), 20260101
  4. Japan Intensive Care Consortium: Nationwide Effort for Extracorporeal Membrane Oxygenation Care Optimization and Excellence Study: Study Protocol., Annals of clinical epidemiology, 7(4), 2025
  5. Translocator protein deficiency promotes splenomegaly with extramedullary hematopoiesis after sepsis., Shock (Augusta, Ga.), 2026
  6. Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients with COVID-19, Critical Care Medicine, 50(10), E744-E758, 20221001
  7. Complex interaction of infusion volumes and confounding factors with lactate clearance in septic shock, Intensive Care Medicine, 50(9), 1545-1546, 20240901
  8. Clinical outcomes of persistent sepsis-associated acute kidney injury in septic shock: a post-hoc analysis of a multicenter prospective cohort study, ANNALS OF INTENSIVE CARE, 16, 2026
    Link to Paper Search Results by DOI
  9. Development and validation of the STeP score for predicting tracheostomy in patients with sepsis using a nationwide ICU database: a retrospective observational study, JOURNAL OF INTENSIVE CARE, 13(1), 20251114
    Link to Paper Search Results by DOI
  10. HEMODYNAMIC RESPONSE BY POLYMYXIN B HEMOPERFUSION AND ITS CLINICAL OUTCOMES IN PATIENTS WITH REFRACTORY SEPTIC SHOCK: A POST-HOC SUBANALYSIS OF PROSPECTIVE COHORT STUDY, SHOCK, 64(4), 397-404, 202510
    Link to Paper Search Results by DOI
  11. Polymyxin B Hemoperfusion for Patients With Septic Shock Requiring High-Dose Norepinephrine: A Multicenter Prospective Cohort Study, CRITICAL CARE EXPLORATIONS, 7(10), 202510
    Link to Paper Search Results by DOI
  12. Complex interaction of infusion volumes and confounding factors with lactate clearance in septic shock, INTENSIVE CARE MEDICINE, 202411
    Link to Paper Search Results by DOI
  13. Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing, Journal of Intensive Care, 13(1), 30, 20250530
  14. Time to administer polymyxin B hemoperfusion and hemodynamics in patients with septic shock requiring high-dose norepinephrine: a predetermined analysis of a prospective cohort study, CRITICAL CARE, 29(1), 20250509
    Link to Paper Search Results by DOI
  15. Lactoferrin Modulates Radiation Response Under Hypoxic Conditions, Possibly Through the Regulation of ROS Production in a Cell Type-Specific Manner, ANTIOXIDANTS, 14(1), 202501
    Link to Paper Search Results by DOI
  16. Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis, CRITICAL CARE, 28(1), 20241024
    Link to Paper Search Results by DOI
  17. Diagnostic utility of plasma translocator protein 18 kDa (TSPO) in sepsis: A case-control study, MEDICINE, 103(44), 20241101
    Link to Paper Search Results by DOI
  18. Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study, PEDIATRIC CRITICAL CARE MEDICINE, 24(9), 715-726, 202309
    Link to Paper Search Results by DOI
  19. Integrated omics analysis with explainable deep networks on pathobiology of infant bronchiolitis, NPJ Syst Biol Appl, 2024
  20. ★, Nasal microRNA signatures for disease severity in infants with respiratory syncytial virus bronchiolitis: A multicentre prospective study, BMJ Open Respir Res, 2024
  21. Association of Nasopharyngeal and Serum Glutathione Metabolism with Bronchiolitis Severity and Asthma Risk: A Prospective Multicenter Cohort Study, Metabolites, 12(8), 674, 2022
  22. Temperature management using an intervascular cooling device for a COVID-19 patient with refractory hyperthermia, Clin Case Rep, 11(4), e7138, 2023
  23. Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS, Respir Res, 24(1), 128, 2023
  24. Respiratory Virus-Specific Nasopharyngeal Lipidome Signatures and Severity in Infants With Bronchiolitis: A Prospective Multicenter Study, J Infect Dis, 228(10), 1410-1420, 2023
  25. Nasopharyngeal fungal subtypes of infant bronchiolitis and disease severity risk, EBioMedicine, 95, 104742, 2023
  26. Mortality in Patients with Obesity and Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation: The Multicenter ECMObesity Study, Am J Respir Crit Care Med, 208(6), 685-694, 2023
  27. Immunocompromised-Associated Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study, Pediatr Crit Care Med, 25(4), 288-300, 2024
  28. External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study, SCIENTIFIC REPORTS, 14(1), 20240221
    Link to Paper Search Results by DOI
  29. Rhythm-control therapy for new-onset atrial fibrillation in critically ill patients: A post hoc analysis from the prospective multicenter observational AFTER-ICU study, IJC HEART & VASCULATURE, 33, 202104
    Link to Paper Search Results by DOI
  30. Combined rupture of left ventricular free wall and pericardium, Intensive Care Medicine, 43, 1858-1859, 201712
    Link to Paper Search Results by DOI
  31. Pediatric cardiorespiratory failure successfully managed with venoarterial-venous extracorporeal membrane oxygenation: a case report, BMC PULMONARY MEDICINE, 16, 20160812
    Link to Paper Search Results by DOI
  32. Exploring Causative Pathology Is Essential for Validating Harmful Effects of Late Intubation, CRITICAL CARE MEDICINE, 44(8), E770-E771, 2016
  33. Factors affecting biomarkers of endothelial and alveolar epithelial dysfunction, INTENSIVE CARE MEDICINE, 42(12), 2111-2112, 2016
  34. Confounders affecting the prognosis in patients with acute decompensated heart failure who underwent extracorporeal membrane oxygenation, Critical Care Medicine, 45(12), e1309-e1309, 201712
  35. Rapid-onset plasma leakage of extracorporeal oxygenation membranes possibly due to hyperbilirubinemia., J Artif Organs, 20180702
  36. Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome An International Multicenter Prospective Cohort, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 200(8), 1002-1012, 20191015
    Link to Paper Search Results by DOI
  37. High serum potassium level is associated with successful electrical cardioversion for new-onset atrial fibrillation in the intensive care unit: A retrospective observational study, ANAESTHESIA AND INTENSIVE CARE, 47(1), 52-59, 201901
    Link to Paper Search Results by DOI
  38. ★, Unique patterns of lower respiratory tract microbiota are associated with inflammation and hospital mortality in acute respiratory distress syndrome, RESPIRATORY RESEARCH, 20(1), 20191106
    Link to Paper Search Results by DOI
  39. Retrospective immunohistological study of autopsied lungs in patients with acute exacerbation of interstitial pneumonia managed with extracorporeal membrane oxygenation, JOURNAL OF THORACIC DISEASE, 11(11), 4436-4443, 201911
    Link to Paper Search Results by DOI
  40. Prognostic impact of sustained new-onset atrial fibrillation in critically ill patients, INTENSIVE CARE MEDICINE, 46(1), 27-35, 202001
    Link to Paper Search Results by DOI
  41. Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study, LANCET RESPIRATORY MEDICINE, 7(2), 115-128, 201902
    Link to Paper Search Results by DOI
  42. Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study, JOURNAL OF CHEMOTHERAPY, 31(7-8), 388-393, 2019
    Link to Paper Search Results by DOI
  43. Prognosis of pathogen-proven acute respiratory distress syndrome diagnosed from a protocol that includes bronchoalveolar lavage: a retrospective observational study, JOURNAL OF INTENSIVE CARE, 8(1), 20200723
    Link to Paper Search Results by DOI
  44. Proteins produced by Streptococcus species in the lower respiratory tract can modify antiviral responses against influenza virus in respiratory epithelial cells, MICROBES AND INFECTION, 23(1), 2021
    Link to Paper Search Results by DOI
  45. Frequency and Risk Factors for Reverse Triggering in Pediatric Acute Respiratory Distress Syndrome during Synchronized Intermittent Mandatory Ventilation, ANNALS OF THE AMERICAN THORACIC SOCIETY, 18(5), 820-829, 202105
    Link to Paper Search Results by DOI
  46. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry., Crit Care Med, 2021
  47. Clinical course after identification of new-onset atrial fibrillation in critically ill patients: The AFTER-ICU study., J Crit Care. 2020 Jul 5;59:136-142., 2020
  48. Primary success of electrical cardioversion for new-onset atrial fibrillation and its association with clinical course in non-cardiac critically ill patients: sub-analysis of a multicenter observational study., Journal of Intensive Care, 2021
  49. Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study., Intensive Care Med, 2020
  50. Predicting Mortality in Children With Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study., Crit Care Med, 2020
  51. Patient-ventilator asynchrony, impact on clinical outcomes and effectiveness of interventions: a systematic review and meta-analysis, JOURNAL OF INTENSIVE CARE, 9(1), 20210816
    Link to Paper Search Results by DOI
  52. Differential Effectiveness of Hypothermic Targeted Temperature Management According to the Severity of Post-Cardiac Arrest Syndrome, JOURNAL OF CLINICAL MEDICINE, 10(23), 202112
    Link to Paper Search Results by DOI

Invited Lecture, Oral Presentation, Poster Presentation

  1. Immunological Perspectives on Acute Radiation Syndrome and Sepsis, 2025/11, With Invitation, English
  2. The trajectory of renal function of sepsis-associated acute kidney injury in septic shock: a multicenter prospective study, Michihito Kyo, Kazuya Kikutani, Kyohei Miyamoto, Yu Kawazoe, Noriko Miyagawa, Hitoshi Yamamura, Yoshiki Ota, Shinichiro Ohshimo, Nobuyuki Hirohashi, Nobuaki Shime, 5th Joint Scientific Congress of TSCCM (Thai) and JSICM, 2025/03/16, Without Invitation, English
  3. Respiratory virus-specific nasopharyngeal lipidome signatures and severity in infants hospitalized for bronchiolitis: A prospective multicenter study, ATS, 2023/05/25, Without Invitation, English
  4. Impact on protocolized diagnostic work-up including Bronchoalveolar lavage for identifying risk factor of acute respiratory distress syndrome: a retrospective observational study, Michihito Kyo, The 20th Joint Scientific Congress of the KSCCM and JSICM, 2020/03/06, Without Invitation, English
  5. Lower respiratory tract microbiota is associated with inflammation and hospital mortality in acute respiratory distress syndrome: a pilot study, Critical Care Canada Forum 2019, 2019/11/12, Without Invitation, English
  6. What does esophageal pressure measurement change in ventilator management? -Case presentation-, Michihito Kyo, Nobuaki Shime, 2019/08/03, With Invitation, English
  7. Impact of inappropriate empiric antibiotic therapy on the mortality inpeadiatric patients with bloodstream infections., Michihito Kyo, Shinichiro Ohshimo, Tadashi Kosaka, Naohisa Fujita and Nobuaki Shime, 30th International Congress of Chemotherapy and Infection, 2017/11/26, Without Invitation, English, International Society of Antimicrobial Chemotherapy, Taiwan
  8. Validation of qSOFA criteria for sepsis, The 46th Critical Care Congress, 2017/01, Without Invitation, English, Hawaii
  9. Successful use of VAV ECMO in a patient with respiratory failure complicated by myocarditis, 2016/04, Without Invitation, English

External Funds

Acceptance Results of Competitive Funds

  1. 2025/04/01, 2028/03/31
  2. 2024, 2025
  3. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2021, 2024
  4. 2021
  5. KAKENHI(Grant-in-Aid for Early-Career Scientists), 2018, 2020

Social Activities

History as Peer Reviews of Academic Papers

  1. 2026, Perfusion, 1
  2. 2026, Respiratory research, 1
  3. 2026, European Respiratory Journal, 1
  4. 2025, Journal of Intensive Care, 1
  5. 2025, Critical Care, 1
  6. 2026, JACEP Open, Editor
  7. 2025, JACEP Open, Editor
  8. 2024, JACEP Open, Editor
  9. 2025, European Respiratory Journal, 1
  10. 2018, Journal of Clinical Medicine, Others, 1
  11. 2018, PLOS ONE, Others, 1
  12. 2019, BMJ Open, Others, 1