HIROYUKI NAITO

Last Updated :2026/07/06

Affiliations, Positions
Hiroshima University Hospital, Assistant Professor
E-mail
naitohi6hiroshima-u.ac.jp

Basic Information

Major Professional Backgrounds

  • 2010/04, 2012/03, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Clinical Resident
  • 2012/04/01, 2013/03/31, Hiroshima University, Neurology, Clinical Fellow
  • 2013/04, 2015/03, Hiroshima Prefectural Hospital, Neurology, Clinical Fellow
  • 2015/04/01, 2016/03/31, Hiroshima University, Neurology, Clinical Fellow
  • 2019/04, 2022/03, Hiroshima City Hiroshima Citizens Hospital, Deputy director
  • 2022/04/01, Hiroshima University, Neurology, Assistant Professor

Educational Backgrounds

  • Hiroshima University, Graduate School of Biomedical & Health Sciences , Japan, 2015/04, 2019/03
  • Hiroshima University, School of Medicine, Japan, 2004/04, 2010/03

Academic Degrees

  • Hiroshima University

In Charge of Primary Major Programs

  • Medicine

Research Fields

  • Medicine,dentistry, and pharmacy;Clinical internal medicine;Neurology

Affiliated Academic Societies

  • The Japanese Society for Neuroimmunology
  • Japan Society for Dementia Research, 2015
  • The Japanese Society of International Medicine, 2010/07
  • Japanese society of neurology, 2012/01
  • The Japan storke society, 2012/02
  • The Japanese Headahce Society, 2012/09
  • Japanese Society of Clinical Neurophysiology, 2015/10
  • The Japan Geriatrics Society, 2020/02
  • Japanese Society of Neurological Therapeutics, 2020/05
  • The Japan of Academy Neurosonology, 2022/11

Educational Activity

Course in Charge

  1. 2026, Undergraduate Education, Year, Medical Neuroscience III
  2. 2026, Undergraduate Education, First Semester, Internal Medicine I

Research Activities

Academic Papers

  1. Simultaneous ultrasound and needle electromyography recording of fasciculations in amyotrophic lateral sclerosis, Clinical Neurophysiology Practice, 11, 448-452, 2026
  2. A case of low-frequency myokymia visualized by simultaneous EMG-ultrasound recording, CLINICAL NEUROPHYSIOLOGY PRACTICE, 11, 348-351, 2026
    Link to Paper Search Results by DOI
  3. Genotype-guided switch from ravulizumab to satralizumab in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder: a case of C5 polymorphism-associated ravulizumab resistance., Neurol Sci, 47(4), 386-386, 20260328
  4. Functional neurological disorder supported by unintentional synergic movement: the hip abductor sign., BMJ Case Rep, 19(1), e269246-e269246, 2026
  5. Ultrasonographic Reference Values of the Brachial Plexus Cross-Sectional Area in Healthy Japanese Adults, Muscle Nerve, 73(2), 277-282, 202602
  6. The periodontal pathogen Fusobacterium nucleatum is associated with disease severity in multiple sclerosis, SCIENTIFIC REPORTS, 15(1), 20251103
    Link to Paper Search Results by DOI
  7. Comparison of prednisolone monotherapy vs. tacrolimus combination in NMOSD: Efficacy, safety, and optimal therapeutic timing, JOURNAL OF NEUROIMMUNOLOGY, 408, 20251115
    Link to Paper Search Results by DOI
  8. Pembrolizumab-associated Neuronopathy with Improved Lower Limb Somatosensory Evoked Potential After Intravenous Methylprednisolone Treatment: A Case Report, INTERNAL MEDICINE, 64(9), 1408-1411, 2025
    Link to Paper Search Results by DOI
  9. Zilucoplan for Successful Early Weaning From Mechanical Ventilation and Avoiding Tracheostomy in an 85-Year-Old Woman Experiencing Myasthenic Crisis: A Case Report., Cureus, 17(3), 20250507
  10. ★, A single-center, single-arm, prospective, open-label, and comparative trial to evaluate the safety and tolerability profile of a 90-day oral L-arginine hydrochloride intervention for patients with amyotrophic lateral sclerosis, SCIENTIFIC REPORTS, 15(1), 20250107
    Link to Paper Search Results by DOI
  11. ★, Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy, JOURNAL OF THE NEUROLOGICAL SCIENCES, 460, 20240515
    Link to Paper Search Results by DOI
  12. Swallowing sound evaluation using an electronic stethoscope and artificial intelligence analysis for patients with amyotrophic lateral sclerosis, FRONTIERS IN NEUROLOGY, 14, 20230803
    Link to Paper Search Results by DOI
  13. Peak expiratory flow, but not tongue pressure, can predict pneumonia development in older adults., Eur Geriatr Med, 20230114
  14. Prognosis Prediction Using Magnetic Resonance Spectroscopy and Oligoclonal Bands in Central Nervous System Methotrexate-associated Lymphoproliferative Disorder., Intern Med, 20220521
  15. Short-term or long-term outcomes for stroke patients with cancer according to biological markers, JOURNAL OF THE NEUROLOGICAL SCIENCES, 436, 20220515
    Link to Paper Search Results by DOI
  16. Pembrolizumab-associated Neuronopathy with Improved Lower Limb Somatosensory Evoked Potential After Intravenous Methylprednisolone Treatment: A Case Report., Intern Med, 202409
  17. ★, Detection of episodic nocturnal hypercapnia in patients with neurodegenerative disorders, SLEEP AND BREATHING, 28(1), 393-399, 202403
    Link to Paper Search Results by DOI
  18. The association between nutritional intake one week after admission and outcome in acute ischemic stroke patients, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 31(11), 202211
    Link to Paper Search Results by DOI
  19. A 36-year-old Man with Repeated Sho rt-term Transient Hyperammonemia and Impaired Consciousness with a Confirmed Ca rbamoyl Phosphate Synthase 1 Gene Monoallelic Mutation1, Intern Med, 61(9), 1387-1392, 202205
  20. Changes in the amplitude decremental response to repetitive nerve stimulation following fast-acting treatment in patients with myasthenia gravis during hospitalization, Clin Exp Neuroimmunol, 202205
  21. Clinical characteristics and tumor markers in ischemic stroke patients with active cancer, INTERNAL AND EMERGENCY MEDICINE, 17(3), 735-741, 202204
    Link to Paper Search Results by DOI
  22. Features of repetitive nerve stimulation and nerve conduction studies in patients with amyotrophic lateral sclerosis, Neurol Clin Neurosci, 11, 134-139, 2023
  23. The association between nutritional intake one week after admission and outcome in acute ischemic stroke patients, Journal of Stroke and Cerebrovascular Diseases, 31, 2022
  24. ★, Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle- Brachial Index, JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 29(5), 719-730, 2022
    Link to Paper Search Results by DOI
  25. Predictors of Stroke Outcome Extracted from Multivariate Linear Discriminant Analysis or Neural Network Analysis, J Atheroscler Thromb, 29(1), 99-110, 2022
  26. Double trouble: A case of spinal muscular atrophy type III found to be complicated by myasthenia gravis due to subacute dysphagia., Clin Exp Neuroimmunol, 2022
  27. Prognosis Prediction Using Magnetic Resonance Spectroscopy and Oligoclonal Bands in Central Nervous System Methotrexate-associated Lymphoproliferative Disorder., Intern Med, 2022
  28. Short-term or long-term outcomes for stroke patients with cancer according to biological markers., J Neurol Sci, 15(436), 2022
  29. Characteristics of cause of death and triggers for crisis in patients with myasthenia gravis, Neurol Clin Neurosci, 10, 147-154, 2022
  30. Clinical comorbidities correlated with a response to the cerebrospinal fluid tap test in idiopathic normal-pressure hydrocephalus., J Neurol Sci, 430, 2021
  31. Brachial plexus neuropathy induced by methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis, Neurol Clin Neurosci, 9, 233-236, 2021
  32. MRI abnormality of the bilateral middle cerebellar peduncles and long-term follow up in hypoglycemic encephalopathy: A case report., Neurol Clin Neurosci, 9, 130-133, 2021
  33. Leptomeningeal myelomatosis with hypertrophy of the cauda equina nerve roots: A case report, Neurol Clin Neurosci, 8, 403-405, 2020
  34. ★, Prognostic role of the controlling nutritional status score in acute ischemic stroke among stroke subtypes, J Neurol Sci, 416, 2020
  35. Effect of tooth loss and nutritional status on outcomes after ischemic stroke, Nutrition, 71, 2020
  36. Initial deterioration and intravenous methylprednisolone therapy in patients with myasthenia gravis, J Neurol Sci, 412, 2020
  37. Effects of vascular compression on the rostral ventrolateral medulla for blood pressure variability in stroke patients, J Hypertens, 38, 2443-2450, 2020
  38. ★, Increased blood pressure variability during the subacute phase in patients with ischemic stroke presenting with a low ankle-brachial index., Geriatr Gerontol Int, 20, 448-454, 2020
  39. ★, Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months, Sci Rep, 10(1), 811, 2020
  40. ★, Controlling nutritional status score for predicting 3-mo functional outcome in acute ischemic stroke, Nutrition, 53, 2533-2537, 2018
  41. Antithrombotic Therapy Strategy for Cancer-Associated Ischemic Stroke: A Case Series of 26 Patients., J Stroke Cerebrovasc Dis, 27, e206-e211, 2018
  42. ★, First report of a Japanese family with spinocerebellar ataxia type 10: The second report from Asia after a report from China., PLoS One, 12, e0177955, 2017
  43. Warfarin-Resistant Deep Vein Thrombosis during the Treatment of Acute Ischemic Stroke in Lung Adenocarcinoma, J Stroke Cerebrovasc Dis, 25, e141-e145, 2016
  44. Magnetic resonance spectroscopy after methanol poisoning, Neurology and Clinical Neuroscience, 4, 112-114, 2016
  45. Prevalences of Peripheral Arterial Disease Diagnosed by CT Angiography in Patients with Acute Ischemic Stroke, J Stroke Cerebrovasc Dis, 25, 1128-1134, 2016
  46. Two cases of acute ischemic stroke associated with iron deficiency anemia due to bleeding from uterine fibroids in middle-aged women, Intern Med, 53, 2533-2537, 2014

Invited Lecture, Oral Presentation, Poster Presentation

  1. Repeated cycles of rozanolixizumab in patients with anti-MuSK antibody-positive generalized MG, Yasushi Suzuki, Artur Drużdż, Ali A. Habib, Dale J. Lange, Renato Mantegazza, Hiroyuki Naito, Robert M. Pascuzzi, Sabrina Sacconi, Kimiaki Utsugisawa, John Vissing, Tuan Vu, Jiann-Horng Yeh, Fiona Grimson, Irene Pulido-Valdeolivas, Thaïs Tarancón, Vera Bril, 38th Annual Meeting of the Japanese Society for Neuroimmunology (JSNI) 2026, 2026/10/22, Without Invitation, Japanese
  2. Repeated cycles of rozanolixizumab treatment in anti-muscle-specific tyrosine kinase antibody-positive generalised myasthenia gravis, Fiammetta Vanoli, Artur Drużdż, Ali A. Habib, Dale J. Lange, Hiroyuki Naito, Robert M. Pascuzzi, Sabrina Sacconi, Kimiaki Utsugisawa, John Vissing, Tuan Vu, Jiann-Horng Yeh, Joel Baldwin, Thaïs Tarancón, Vera Bril, International Congress on Neuromuscular Diseases (ICNMD) 2026, 2026/07, Without Invitation, English
  3. Distinct Contributions of Brain Volume and Myelin to Cognitive Function in MS and NMOSD: A Synthetic MRI Study, Ishihara K, Naito H, Sugimoto T, Tagane Y, Tasaka S, Muguruma T, Toko M, Nakamori M, Yamazaki Y, Ochi K, Maruyama H, ECF Update on NMOSD and MOGAD 2026, 2026/02, Without Invitation, English
  4. REPEATED CYCLES OF ROZANOLIXIZUMAB TREATMENT IN PATIENTS WITH ANTI-MUSCLE-SPECIFIC TYROSINE KINASE ANTIBODY-POSITIVE GENERALIZED MYASTHENIA GRAVIS, Ali A. Habib, Artur Drużdż, Dale J. Lange, Renato Mantegazza, Hiroyuki Naito, Robert M. Pascuzzi, Sabrina Sacconi, Kimiaki Utsugisawa, John Vissing, Tuan Vu, Jiann-Horng Yeh, Fiona Grimson, Irene Pulido-Valdeolivas, Thaïs Tarancón, Vera Bril, MGFA Scientific Session 2025, 2025/10/29, Without Invitation, English
  5. VALIDATION OF THE MODIFIED CONTROLLING NUTRITIONAL STATUS SCORE AND STUDY OF CRITICAL EVENTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS, Tazuma T, Nakamori M, Toko M, Watanabe T, Naito H, Kanaya Y, Agari D, Shishido T, Imamura E, Imon K, Nomura E, Torii T, Miyachi T, Yamashita H, Ohshita T, Maruyama H, 16th World Congress of Neurology (WCN2025)., 2025/10, Without Invitation, English
  6. Association of periodontal pathogen with subtypes of motor symptoms of Parkinson's disease, Yamada H, Nakamori M, Nishi H, Naito H, Yamazaki Y, Maruyama H, International Congress of Parkinson's Disease and Movement Disorders, 2025/10, Without Invitation, English
  7. Cellular density of neuromuscular medullary thymic epithelial cells in thymic tissues from patients with myasthenia gravis and asymptomatic individuals: a histopathological study, Tagane Y, Sugimoto T, Naito H, Nakamori M, Yamazaki Y, Miyata Y, Takeshima Y, Arihiro K, Okada M, Maruyama H, 17th International Congress of Neuroimmunology, 2025/10, Without Invitation, English
  8. Post-Onset Fractures in Demyelinating Diseases: Risk Factors and Preventive Implications, Sugimoto T, Naito H, Ueno H, Nakamori M, Ochi K, Yamawaki T, Yamazaki Y, Maruyama H, 17th International Congress of Neuroimmunology, 2025/10, Without Invitation, English
  9. Utility of Synthetic MRI-Based Brain Volume and Myelin Quantification for Evaluating Cognitive Impairment in Patients with Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder, Hiroyuki Naito, Keito Ishihara, Takamichi Sugimoto, Yuichiro Tagane, Saki Tasaka, Tomoko Muguruma, Megumi Toko, Masahiro Nakamori, Yu Yamazaki, Kazuhide Ochi, Hirofumi Maruyama, 17th International Congress of Neuroimmunology, 2025/10, Without Invitation, English
  10. Increased blood pressure variability during the subacute phase and a low ABI independently predict with 3-month outcome with acute ischemic stroke, 2019, Without Invitation, Japanese
  11. Controlling Nutritional Status score for predicting 3-mo functional outcome in acute ischemic stroke, 2019, Without Invitation, Japanese
  12. Increased Blood Pressure Variability During the Subacute Phase is Associated With 3-month Functional Poor Outcome in Patients With Acute Ischemic Stroke, 2019, Without Invitation, Japanese
  13. Controlling Nutritional Status score predicts 3-month functional outcome in patients with acute ischemic stroke, 2018, Without Invitation, Japanese
  14. Associations between clinical subtypes of acute ischemic stroke and peripheral artery disease., 2014, Without Invitation, Japanese

External Funds

Acceptance Results of Competitive Funds

  1. 2026/04, 2029/03
  2. 2024, 2027
  3. 2023/04
  4. 2023/04, 2024/03

Social Activities

Other Social Contributions

  1. MG Clinical Seminar, 2026/06/26, 2026/06/26, Lecturer, Lecture, Scientific organization
  2. Neurology Expert Conference, Neurology Expert Conference, 2025/12, Panelist, Lecture, Scientific organization